Synthesis of n-substituted oligomers.

Solid phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycols) (herein referred to as poly NSG) is used to obtain oligomers, such as poly NSG with potential therapeutic interest. These poly NSGs can have many different sled chain substituents. Each N-substituted glycine monomer is set up from two "sub-monomers" directly on the solid support. Each monomer addition cycle consists of two steps: (1) acylation of a second amine bonded to the support with an acylation agent comprising a cleavable group capable of nucleophile displacement of -NH such as halogen (as a resin-linked α-haloacetamide) with a sufficient amount of another sub-monomer comprising an -NH Repetition of the two-step cycle which includes acylation and displacement adds the desired oligomers. The efficient synthesis of various oligomeric NSGs using automated synthesis technology In accordance with the present invention, these oligomers make attractive candidates for the formation and rapid screening of various peptidomimetic libraries. The oligomers, then N-substituted glycines (i.e. poly NSG) provides a new class of peptide-containing compound not found in nature but which is synthetically obtainable and which has been shown to have significant biological activity and proteolytic stability.