Method for preparing particles of uniform size from water- insoluble organic compounds
Abstract
The invention relates to a method for preparing particles of uniform size from drugs or other water-insoluble organic compounds. Firstly, a suitable solid organic compound is dissolved in an organic solvent and the solution may be diluted with a non-solvent liquid. Next, an aqueous precipitant liquid is infused, precipitating non-aggregated particles with substantially uniform mean diameters. The particles are then separated out from the organic solvent. Depending on the organic compound and on the size of the particles which is desired, in accordance with the invention the parameters of temperature, ratio of non-solvent liquid to organic solvent, speed of infusion, speed of agitation and volume may vary.
Term
No projected expiry on record.
- Priority
- Filed and published
- Today
1 claim: 1 independent, 0 dependent
- 1IDS3N2 IDS3N2
2 paragraphs, as filed
The invention includes a process for preparing particles of uniform size from solid compounds. First, a suitable solid compound is dissolved in a suitable solvent. Then, a precipitating fluid is applied during precipitation of non-aggregated particles having substantially uniform mean diameter. The particles are then separated from the solvent. Depending on the solid compound and the desired particle size, the temperature, non-solvent and solvent ratio, feed rate, agitation rate, and volume parameters can be varied according to the invention. The precipitation liquid may be aqueous or non-aqueous depending on the relative solubility of the compound and the desired suspending carrier.
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1 sheet
Sheet 1
28 members in 15 offices
Priority claims7
| Document | Office | Kind | Date |
|---|---|---|---|
| 61272584 | United States of America | A | |
| 61272584 | United States of America | A | |
| 9004735 | United States of America | W | |
| 9004735 | United States of America | W | |
| 90US9004735 | – | – | – |
| US19840612725 | – | – | – |
| WO1990US04735 | – | – | – |
Members28
| Document | Office | Kind | |
|---|---|---|---|
| IL75250D0 | Israel | D0 | |
| PT80494A | Portugal | A | |
| EP0169618A2 | European Patent Office (EPO) | A2 | |
| ES8607007A1 | Spain | A1 | |
| AU4501285A | Australia | A | |
| JPS6227032A | Japan | A | |
| PT80494B | Portugal | B | |
| EP0169618A3 | European Patent Office (EPO) | A3 | |
| NZ212151A | New Zealand | A | |
| IL75250A | Israel | A | |
| AU579166B2 | Australia | B2 | |
| US4826689A | United States of America | A | |
| EP0169618B1 | European Patent Office (EPO) | B1 | |
| AT55921T | Austria | T | |
| DE3579385D1 | Germany | D1 | |
| US4997454A | United States of America | A | |
| CA1282405C | Canada | C | |
| CA2089075A1 | Canada | A1 | |
| WO9203380A1 | World Intellectual Property Organization (WIPO) | A1 | |
| FI930693A | Finland | A | |
| NO930571D0 | Norway | D0 | |
| NO930571LThis record | Norway | L | |
| EP0544657A1 | European Patent Office (EPO) | A1 | |
| KR930701346A | Republic of Korea | A | |
| EP0544657A4 | European Patent Office (EPO) | A4 | |
| EP0169618B2 | European Patent Office (EPO) | B2 | |
| JPH06501872A | Japan | A | |
| JPH072209B2 | Japan | B2 |
Numbers
- Publication
- 19930571
- Publication, DOCDB
- 930571
- Publication, EPODOC
- NO930571L
- Application
- 93930571
- Application, DOCDB
- 930571
- Application, EPODOC
- NO19930000571
Titles2
- Norwegian
- FREMGANGSMAATE FOR FREMSTILLING AV PARTIKLER MED JEVN STOERRELSE FRA UOPPLOESELIGE FORBINDELSER
- English
- PROCEDURE FOR MANUFACTURING PARTICLES WITH YOUR SIZE FROM INSULABLE RELATIONS
Classification
- IPC, 8
- A61J3 00
- A61K9 00
- A61K9 14
- B01D43 00
- B01J
- B01J2 00
- B01J2 02
- B01J13 00