Cytokine fused to immunoglobulin fc heterodimer and pharmaceutical composition comprising same

The present invention relates to a heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein, wherein in the heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of a Fc region pair of an immunoglobulin while a subunit of a biologically active protein is bound to at least one of N-terminal or C-terminal of the first Fc region and/or the second Fc region, the first Fc region and the second Fc region are CH3 domains modified to promote the formation of a heterodimer. In the heterodimeric Fc-fused protein according to the present invention, two or more subunits form a protein complex, so that a protein constituting a biologically active protein can be fused to Fc in an original shape and structure as the protein exists in nature and thus the protein can maintain an original activity as the protein exists in nature. The use of the heterodimeric Fc-fused protein according to the present invention remarkably increases the <i>in vivo</i> half-life of a biologically active protein contained in the heterodimeric Fc-fused protein, and thus various types of biological activities can be maintained for a long time in the body.