System and method for embryo control.
23 claims: 8 independent, 15 dependent
- 1REIVINDICACIONES IMPIOS ¡NSTin de LA r'· · ;.·’ ió7k;al 1. Un sistema para tratar a un paciente humano o mamífero del género femenino para evitar el embarazo, el sistema está caracterizado porque comprende un dispositivo de accionamiento enerqizado y al menos un dispositivo de restricción (2) adaptado para ser ajustado postquirúrgicamente por el dispositivo de accionamiento energizado (34) que está energizado por energía eléctrica, magnética o hidráulica para restringir y liberar al menos un oviducto (31a, 31b) del paciente, en donde dicho dispositivo de restricción está adaptado para ser ajustado reversiblemente y en donde dicho sistema comprende un dispositivo de control (4) para controlar el dispositivo de accionamiento energizado para ajustar el al menos un dispositivo de restricción, adaptado para ser colocado sobre el al menos un oviducto para evitar el embarazo.
- 2El sistema de conformidad con la reivindicación 1, caracterizado además porque el dispositivo de restricción está adaptado para proporcionar una restricción del oviducto para acumular al menos un óvulo liberado del ovario en el oviducto.
- 3El sistema de conformidad con la reivindicación 2, caracterizado además porque el dispositivo de restricción está adaptado para proporcionar τ -117- una liberación del oviducto únicamente cuando el embarazo es deseado o no posible.
- 4El sistema de conformidad con la reivindicación 3, caracterizado además porque el dispositivo de restricción está adaptado para ser ajustado desde el exterior del cuerpo del paciente para restringir y liberar el conducto del oviducto.
- 5El sistema de conformidad con la reivindicación 4, caracterizado además porque el dispositivo de restricción está adaptado para ser ajustado hidráulica comprende al menos un depósito subcutáneo (74) controlado por el paciente.
- 67. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 6, caracterizado además porque el dispositivo de restricción está adaptado para proporcionar una restricción para acumular al menos un óvulo liberado del ovario en el oviducto durante un período de tiempo predeterminado, y liberar la restricción cuando sea conveniente para el paciente evitar el embarazo.
- 78. El sistema de conformidad con la reivindicación 7, caracterizado además porque el período de i -118χ / el tiempo predeterminado está K T?i x Jyi r i r· instituto v · i Df LA ’A.G INDU-TAJaL para evitar embarazo.
- 89. El sistema de conformidad con la reivindicación 7, caracterizado además porque el período de tiempo predeterminado está entre 2 y 30 días.
- 910. El sistema de conformidad con la reivindicación 7, caracterizado además porque el período de tiempo predeterminado es mayor a 30 días.
- 1011. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 10, caracterizado además porque dicho dispositivo de restricción comprende más de un área de restricción, en donde dicho dispositivo de restricción está adaptado para cambiar el área de restricción con el tiempo.
- 1112 . El sistema de conformidad con la reivindicación 11, caracterizado además porque el cambio del área de restricción está adaptado para prevenir cualquier daño al oviducto pero aun manteniendo el oviducto cerrado evitando que cualquier óvulo pase hacia abajo al útero, y de esta manera evitar el embarazo.
- 1213. El sistema de conformidad con la reivindicación 12, caracterizado además porque comprende un dispositivo de restricción hidráulica con dos o más áreas de restricción.
- 1314. El sistema de conformidad con la -119reivindicación 13 caracterizado además IMP1 INSTITUTO MEXICANO .· .* DE LA FROPIcDaD porque cdttfpS^ftdé^tm—' depósito hidráulico conectado a dicho —día pe 0444^^0--^¾ restricción, en donde el dispositivo de restricción hidráulica con dos o más áreas de restricción está conectado al depósito con fluido hidráulico adaptado para mover el fluido hacia o desde el dispositivo de restricción y que adicionalmente comprende al menos una válvula para dirigir el fluido individualmente hacia o desde las áreas de restricción para restringir o liberar individualmente las áreas de restricción.
- 1415. El sistema de conformidad con la reivindicación 13, caracterizado además porque comprende dos o más depósitos hidráulicos conectados uno a cada una de las diferentes áreas restricción, en donde el hidráulica con dos o más de dicho dispositivo de dispositivo de restricción áreas de restricción está conectado a los dichos depósitos dos o más depósitos con fluido hidráulico, están adaptados para mover el fluido hacia o desde dichas áreas de restricción individualmente hacia o desde cada una de las áreas de restricción conectadas para restringir o liberar la restricción en el área de restricción individual.
- 1516. El sistema de conformidad con cualquiera de las reivindicaciones 13 a 15, caracterizado además porque cada una de las áreas de restricción hidráulica está I ι -120IMPIDA INSTITUTO MhXlCAN > .4 LE LA FROHEDal) IN UU3TJUAL adaptada para ser restringida por un período de tiempo predeterminado con alguna superposición en el tiempo y adaptada para restringir primero el área de restricción más cercana al ovario, después cambiar el área de restricción a la siguiente hacia el útero.
- 1617. El sistema de conformidad con cualquiera de las reivindicaciones 14 a 16, caracterizado además porque cada una de las áreas de restricción hidráulica está adaptada para ser regulada por manipulación manual de dichos depósitos.
- 1718. El sistema de conformidad con la reivindicación 12, caracterizado además porque comprende un dispositivo de de restricción en combinación con un dispositivo de restricción hidráulica o mecánica.
- 1819. El sistema de conformidad con la reivindicación 18, caracterizado además porque el dispositivo de restricción hidráulica o mecánica está restringiendo solo parcialmente el oviducto y el dispositivo de estimulación estimula para restringir completamente el oviducto.
- 1920. El sistema de conformidad la reivindicación 19, caracterizado además porque el dispositivo de estimulación estimula diferentes áreas del oviducto para variar el área del oviducto que está completamente -121restringida.
- 2021. El sistema de conformidad con cualquiera de las reivindicaciones 12 a 20, caracterizado además porque el cambio del área de restricción está adaptado para provocar una onda peristáltica como onda de restricción en la dirección hacia el ovario para evitar que el óvulo sea transportado hacia abajo, al útero.
- 2122. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 21, caracterizado además porque el dispositivo de restricción está adaptado para efectuar un transporte de el al menos un óvulo al útero ante la liberación del oviducto. El sistema de conformidad con la reivindicación 22, caracterizado además porque el dispositivo de restricción está adaptado para provocar una onda peristáltica como onda de restricción en la dirección hacia el útero.
- 2224. El sistema de conformidad con cualquiera de las reivindicaciones 12 a 23, caracterizado además porque comprende un dispositivo de movimiento adaptado para mover dispositivo de* movimiento es el mismo dispositivo que el 122INSTrn 'ΤΟ M F.XJCAN-O o:la ρ.;···νι~.ΓΜ·/ V*.*~-J2LJ !i -•L-JÍ/rkiAL Zg* dispositivo de restricción, adaptado para funcionar de manera diferente cuando restringe o provoca movimientos del óvulo. 26. El sistema de conformidad con la reivindicación 24, caracterizado además porque el dispositivo de movimiento es un dispositivo diferente que el dispositivo de restricción adaptado para funcionar de manera diferente cuando restringe o provoca movimientos del óvulo. 27. El sistema de conformidad con cualquiera de las reivindicaciones 24 a 26, caracterizado además porque el dispositivo de movimiento provoca movimientos de vibración o similares a onda en la pared del oviducto con lo que provoca movimientos del óvulo. 28. El sistema de conformidad con cualquiera de las reivindicaciones 24 a 27, caracterizado además porque el dispositivo de movimiento comprende un dispositivo de movimiento mecánico. 29. El sistema de conformidad con cualquiera de las reivindicaciones 24 a 27, caracterizado además porque el dispositivo de movimiento comprende un dispositivo de movimiento hidráulico. 30. El sistema de conformidad con cualquiera de las reivindicaciones 24 a 27, caracterizado además porque dicho dispositivo de movimiento comprende un dispositivo de -123- INSTíTUT ' MFX!Ca«O ¿ -Cfc LA VIFJVD ' INOUSTiljAL estimulación. 31. El sistema de conformidad con cualquiera de las reivindicaciones 24 a 27, caracterizado además porque dicho dispositivo de movimiento comprende un dispositivo de estimulación combinado con un dispositivo de movimiento mecánico o hidráulico. 32. El sistema de conformidad con cualquiera de las reivindicaciones 28 a 30, caracterizado además porque el dispositivo de movimiento comprende cualquier combinación de dispositivos de movimiento. 33. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 32, caracterizado además porque el dispositivo de restricción comprende un dispositivo de restricción mecánica. 34. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 32, caracterizado además porque el dispositivo de restricción comprende un dispositivo de restricción hidráulica. 35. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 32, caracterizado además porque dicho dispositivo de restricción comprende un dispositivo de estimulación. 36. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 32, caracterizado además porque dicho dispositivo de restricción comprende un dispositivo t -124- de estimulación combinado IMPI INSTITUTO MEXICANO £>F LA PROPltDAL) con un dispositivo mecánica o hidráulica. 37. El sistema de conformidad con cualquiera de las reivindicaciones 33 a 35, caracterizado además porque el dispositivo de restricción comprende cualquier combinación de dispositivos de restricción. interna (33) adaptada para ser implantada en el cuerpo del paciente, en donde el control del dispositivo de restricción se realiza por dicha unidad de control interna. 40. El sistema de conformidad con la reivindicación 39, caracterizado además porque comprende un sensor (36) que detecta al menos un parámetro físico del paciente. 41. El sistema de conformidad con la reivindicación 40, caracterizado además porque la unidad de control interna controla el dispositivo de restricción para restringir dicho oviducto con base en la información de -125INSTiTUTC MEXICANO I / L'E LA i·» O i >£'.> t-vINDUSTRIAL conformidad' ...-eoR...—tadicho sensor. 42. El sistema de reivindicación 38, caracterizado además porque comprende un sensor que detecta al menos un parámetro físico del paciente, en donde el dispositivo de control controla el dispositivo de restricción con base en la información de dicho sensor. 43. El sistema de conformidad con la reivindicación 39, caracterizado además porque comprende un sensor que detecta al menos un parámetro funcional del dispositivo de restricción. 44. El sistema de conformidad con la reivindicación 43, caracterizado además porque la unidad de control interna controla el dispositivo de restricción para restringir dicho oviducto con base en la información de dicho sensor. 45. El sistema de conformidad con la reivindicación 38, caracterizado además porque comprende un sensor que detecta al menos un parámetro funcional del dispositivo de restricción, en donde el dispositivo de control controla el dispositivo de restricción con base en la información de dicho sensor. 46. El sistema de conformidad con la reivindicación 40 ó 42, caracterizado además porque dicho sensor está adaptado para detectar un nivel de hormonas o -126- una temperatura. 47. El sistema de con f o r mi reivindicación 43 ó 45, caracterizado además porque dicho sensor está adaptado para detectar un parámetro eléctrico o 5 una presión relacionada al dispositivo de restricción. 48. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 47, caracterizado además porque comprende una fuente de energía que energiza el dispositivo de restricción, en donde dicha fuente de energía es una LO fuente de energía interna (35) adaptada para ser cargable por energía inalámbrica, y que adicionalmente comprende un transmisor para transmitir energía inalámbrica para cargar dicha fuente de energía interna. 49. El sistema de conformidad con cualquiera de 15 las reivindicaciones 1 a 47, caracterizado además porque está adaptado para enviar información de retroalimentación desde el interior del cuerpo al exterior del mismo para proporcionar retroalimentación relacionada con cualquier parámetro funcional del dispositivo de restricción o 20 parámetro físico del paciente. 50. El sistema de conformidad con la reivindicación 48, caracterizado además porque está adaptado para enviar información de retroalimentación desde el interior del cuerpo al exterior del mismo para
- 2325 proporcionar retroalimentación relacionada con cualquier λ i -127parámetro IMPIS -λ funcional del dispositivo dé NST t^SO'rjbcck©íh INDUSTRIAL -----parámetro físico del paciente. 51. El sistema de conformidad con la reivindicación 50, caracterizado además porque el parámetro funcional del dispositivo de restricción está correlacionado con la transferencia de energía para cargar la fuente de energía interna. 52. El sistema de conformidad con la reivindicación 51, caracterizado además porque el parámetro funcional del dispositivo de restricción es el balance de energía, el balance entre la energía recibida y la energía utilizada incluyendo la acumulada por el dispositivo de restricción. 53. El sistema de conformidad con la reivindicación 52, caracterizado además porque el balance de energía es el balance entre una energía de velocidad de recepción y una energía de uso que incluye velocidad de acumulación. 54. El sistema de conformidad con cualquiera de las reivindicaciones 36 a 53, caracterizado además porque el dispositivo de control comprende un dispositivo de control mecánico. 55. El sistema de conformidad con cualquiera de las reivindicaciones 36 a 47, caracterizado además porque el dispositivo de control comprende un dispositivo de t -128- control hidráulico. Of. 'A PrjHl·.:»' !NuU5WAL 56. El sistema de conformidad con cualquiera de ------- Μ*·»·.. I » las reivindicaciones 36 a 47, caracterizado además porque dicho dispositivo de control comprende un dispositivo de estimulación. 57. El sistema de conformidad con cualquiera de las reivindicaciones 1 a 56, caracterizado además porque comprende una fuente de energía que energiza al dispositivo de restricción. 58. El sistema de conformidad con las reivindicaciones 36 a 47, y 54 a 56, cualquiera de caracterizado además porque el dispositivo de control comprende un transmisor de energía inalámbrica para transferencia inalámbrica de energía para energizar el dispositivo de restricción durante la transferencia de energía. 59. El sistema de conformidad con la reivindicación 57, caracterizado además porque el sistema comprende una fuente de energía interna para energizar el dispositivo de restricción. 60. El sistema de conformidad con la reivindicación 59, caracterizado además porque comprende un transmisor de energía inalámbrica para la transferencia inalámbrica de energía para cargar la fuente de energía interna, que es recargable. 61. El sistema de conformidad con la Λ IMPI INSTITUTO MEXICANO Ot LA ΓΚ IPIECAD INDUSTRIAL reivindicación 59, caracterizado además porgue la fuente de energía interna está controlada desde '’eT'exEerior del cuerpo del paciente. 62. El sistema de conformidad con la reivindicación 61, caracterizado además porque la fuente de energía interna se controla con un control remoto inalámbrico (32). 63. El sistema de conformidad con la reivindicación 61, energía interna se caracterizado además porque la fuente de controla con un interruptor implantado en el cuerpo humano adaptado para ser regulado desde el exterior del cuerpo. 64. El sistema para evitar el embarazo, de conformidad con la reivindicación 12, caracterizado además porque está adaptado para restringir una primera parte o área de un oviducto del paciente para proporcionar una restricción para acumular al menos un óvulo liberado del ovario en el oviducto durante un periodo de tiempo predeterminado, y adaptado para restringir una segunda parte del oviducto y posteriormente liberar la restricción de la primera parte. 65. El sistema de conformidad con la reivindicación 64, caracterizado además porque adicionalmente está adaptado para liberar la restricción de la segunda parte, de modo que permite el transporte del -130I de conformidad con la óvulo hacia abajo, al útero. 66. El sistema reivindicación adaptado para posteriormente 67. reivindicación adicionalmente 65, caracterizado restringir una tercera liberar la restricción El sistema 66, de IM ijwiW m oí la 1N£ TJ-JZ.L además porque está parte del oviducto y de la segunda parte. conformidad caracterizado además con la porque está adaptado para liberar la restricción de la tercera parte óvulo hacia abajo, 68 . El reivindicación adaptado para posteriormente 69. reivindicación adicionalmente de modo que permite el transporte al útero. sistema de conformidad con del la 67, caracterizado restringir una cuarta liberar la restricción El sistema 68, de además porque está parte del oviducto y de la tercera parte. conformidad caracterizado además con la porque está adaptado para liberar la restricción de la cuarta parte, óvulo hacia abajo, 70. El de modo que permite el transporte del al útero. sistema de conformidad con cualquiera de las reivindicaciones 1 a 12, caracterizado además porque está adaptado para restringir la primera parte del oviducto más cercano al ovario para permitir que la segunda restricción sea restringida sin interferir con ningún óvulo 25 acumulado. -13171. El sistema de IMPI iHrmrrro mexican i w. la nonnMv conformidad reivindicación 70, caracterizado además-— ·ρο·ι?·^Η·θ'·.»·'·.&8ί»ά adaptado para tener más de dos áreas de restricción y variar el área de restricción mientras al menos un área de 5 restricción está cerrada cuando el dispositivo de restricción está en el modo de restricción. 72. El sistema de conformidad con la reivindicación 70, caracterizado además porque está adaptado para restringir las áreas de restricción en orden 10 consecutivo comenzando con el área de restricción, parte del oviducto más cercana al ovario y posteriormente restringir cualquier área nueva una etapa más cercana al útero, y adicionalmente adaptada para superponer en tiempo la restricción de dos áreas consecutivas de restricción de 15 esta manera adaptadas para restringir sin interferir con ningún óvulo acumulado. -132-
Independent claims23
843 paragraphs in 60 sections, as filed
(54) Title: EMBRYO CONTROL SYSTEM AND METHOD.
(54) Title: SYSTEM AND METHOD FOR EMBRYO CONTROL.
(57) Summary
A system for treating a female patient to promote pregnancy comprising a restraining device adapted to post-operatively restrict and release a patient's fallopian tube.
(57) Abstract
A system for treating a female patient to promote pregnancy comprising a restriction device adapted to postoperatively restrict and release an oviduct of the patient.
PATENT TITLE No. 353172
Headlines):
TESLUX HOLDING SA
D micilio:
D nomination;
rue Guillaume Schneider, L-2522, Luxembourg, LUXEMBOURG
EMBRYO CONTROL SYSTEM AND METHOD.
<td>Classification:</td><td>CIP: A61B17 / 12; A61B17 / 425; A61F6 / 22; A61N1 / 36 CPC: A61B17 / 12 <sup>:</sup></td>
Inventor (s);
PETER
Validity: Vá | nte años
<img file="MX353172B_D0001.tif" />
Vi l í f
Number: <
MX / a / 2010/003988 rnational
Number:
60/960,715
60/900,716
60/960,918
Expiration Date * 1Ó dttubre dfe 2028
Shipping date: January 5, 2018 κ,.
': ·>,> «R
The patent of references © It grants with foundation eri the ^ rtifiajIoS'l<sup>0</sup>, 2<sup>or</sup> fraction
Pursuant to article Le and ^ Ja Inátaffi Property ** from the date of filing We Ja application mtenWeteOaly est ^ á su] i / -Sédela tey'de la Pro
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Industrial.
twenty years non-extendable, counted to Mr. current rights.
Who subscribes to the present title lojj (Official Gazette of the Federation (01/25/2006, 06/05 / 2009,06 / 01/2010, Regulations of the Mexican Institute of the<sup>;! </sup>Articles 1, 3, 4, 5, section V, subsection a), 12/27/1999, amended on 10/10/2002, 07/29/20 «» Deputy Generals, Coordinator, Departmental Directors and other subordinates of the Mexi Institute 08/04/2004 and 09/13/2007).
orfK III and. ^ AI ^ Í, of the Industrial Property Law 2/1997: 1WQ6A1999, 01/26/2004, 06/16/2005, ra & QpWAjío a), 4<sup>or</sup> and 12<sup>or</sup> fractions I and III of ρΛ & ^! ΐβώ7 / 2004, 07/28/2004 and 09/07/2007); ^ JAexicano of Industrial Property (DOF: I agree that it delegates powers to the Directors, Divisional Deputy Directors, Coordinators! F. 12/15/1999, amended on 02/04/2000, 07/29/2004,
This letter is signed with an advanced electronic signature (FIEL), based on articles 7 BIS 2 of the Industrial Property Law; 3 of its Regulations, and 1 fraction III, 2 fraction V, 26 BIS and 26 TER of the Agreement establishing the guidelines for the use of the Electronic Payment and Services Portal (PASE) of the Mexican Institute of Industrial Property, in the procedures indicated.
THE DIVISIONAL DIRECTOR OF PATENTS
<img file="MX353172B_D0003.tif" />
NAHANNY CANAL REYES
Original string:
NAHANNY MARISOL CANAL REYES | 00001000000403252793 | Administration Service
Tax | 1695 || MX / 2018/2484 | MX / a / 2010/003938 | PCT patent title | 1220 | RRGO | Page (s) | 7m94gCr / c1 pETwseqGn6RvBQchk =
Digital stamp:
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MRX9 / MLoDDQuWVIeGo7aOxgh6nuM99nsKSvp + UvNVwzxUoc35zCGfTykmwQTQvLSInhHiF9F9Mza8NTZI9yUVK2430 pFJfymJQxWSUr8uo3vThm6hQAS9IETkDPz¡PD3mMbdST6HijZqJPGRW0t6AsSbQ4fE0C65cGqee / SiqY09mCPihrSu 9sAJcKMVyPCpZdrWKTehLXMv9jXmcgh28egYlmmwu2 + L8 + == nelyL7TZhfZ5kTYKIHCDFSRfvw
Arenal No. 550. Floor 1, Pueblo Santa María Tepepan, Xochimilco, 16020. Mexico City.
(55) 53340700 www.gob.mx/impi
<img file="MX353172B_D0004.tif" />
MX / 2018/2484
<img file="MX353172B_D0005.tif" />
j2Ü3. ^ 38
<img file="MX353172B_D0006.tif" />
*·
35W
IMPI
INSTITUTO MEXÍCAN J Lí LA PROriEOAP EMBRYO CONTROL SYSTEM AND METHOD ^ τ «i> .l
TECHNICAL FIELD
The present invention relates generally to medical devices and treatment, and more particularly, to a system and method for embryo control of a female patient.
BACKGROUND
Many women do not want to become pregnant but do not want to use the existing pregnancy control methods available.
BRIEF DESCRIPTION OF THE INVENTION
The objective of the present invention is to provide a system and method for pregnancy control of a female patient.
The system of the invention allows the ovum of the ovary to be retained in the oviduct to prevent pregnancy. A restraining device is placed in the two oviducts to restrict and release the oviduct, whereby the aforementioned retention is carried out before the ovum.
In accordance with a first aspect of the present invention, there is provided a system for treating a female patient to prevent pregnancy comprising a restriction device adapted to
<img file="MX353172B_D0007.tif" />
<img file="MX353172B_D0008.tif" />
-2restrict postsurgically and
i.
IMPI instituto mexican>?> ***! & Va. ¡Η VI LA LA0FI6DA.0 <«* _ΛκΖ release an iN0¡j ¿* auc> eL3» aS! R patient.
In accordance with a second aspect of the invention, there is provided a method of preventing pregnancy of a patient comprising the steps of restricting an oviduct from the patient to provide a restriction to accumulate at least one ovum released from the ovary into the oviduct during a predetermined period of time and release the restriction to admit at least one egg into the oviduct for transport to the uterus.
All the modalities and characteristics described in the following are possible to be used for both and can be adapted to be used with the apparatus and are used with any of the methods described in the following.
A system for treating a patient to prevent pregnancy comprises: a restraining device adapted to restrain post-operatively and release an oviduct from the patient.
The restriction device is preferably adapted to provide a restriction to the oviduct to accumulate at least one ovum released from the ovary into the oviduct.
The restriction device can be adapted to provide a release from the oviduct only
<img file="MX353172B_D0009.tif" />
<img file="MX353172B_D0010.tif" />
-3when pregnancy or restriction is desired, it can be adapted
The device is to be adjusted from the outside of the patient's body to restrict and release the duct from the oviduct, preferably adjusted from the outside of the patient's body in a non-invasive manner.
It can also be adjusted by manual manipulation or it can be adapted to be adjusted by electric or magnetic energy or adapted to be adjusted by hydraulic energy. Hydraulic power may comprise at least one subcutaneously placed reservoir controlled by the patient.
The restriction device is of course preferably adapted to be reversibly adjusted.
The system is adapted to provide a restriction to accumulate at least one ovum released from the ovary into the oviduct for a predetermined period of time and release the restriction when convenient for the patient, to prevent pregnancy. The predetermined period of time is adapted to prevent pregnancy and can be between 1 and 30 days or a predetermined period of time greater than 30 days.
FLOW RESTRICTION
The system of the present invention is suitable
-4for control of egg flow
<img file="MX353172B_D0011.tif" />
patient
Basically the device, γρϊΊ; KÍcrzión p.ne, de, be carried out on eight different principles:
Hydraulic restrictions
Mechanical restraints
Combination of any hydraulic or mechanical restraining device with a restraining stimulation device.
Stimulation device only for restriction.
Variation of the restriction area.
Any of these in any combination can be used to vary, over time, the restriction area of the oviduct from one portion to the other and then back again. Several different areas may be involved in such a system to vary the restriction portion / area. This can allow the oviduct to regain the restricted area and still maintain the restriction for a longer period.
Use of a mobile device. When the restriction area moves between different areas, especially when the restriction moves upstream, towards the ovary, it may be convenient to use a mobile device to prevent any ovum from being compressed in a new upstream restriction area
-5; -Λ r · t.
Í; .V <sup>1</sup> i '. ; ·
IM and mistakenly released for additional ccVl / down-q. ^ Transport when the constraint is released v<sub>L</sub> additionally moves upstream. The mobile device can be adapted to create movement of the wall of the oviduct to create movement of any ovum placed in the new incoming restricted area. This may be caused by any of the aforementioned restraining devices, a mechanical, hydraulic, or pacing device alone or any combination, but may also be a separate device which may also be a mechanical, hydraulic, or pacing device.
In one embodiment, the mobile device causes vibrations.
A peristaltic wave motion from the wall of the oviduct toward the ovary. Another principle is to stop or prevent the egg from reaching the uterus by generating wave-like peristaltic movements of the wall of the oviduct. Said wave-like peristaltic movement in the upstream direction towards the ovary can stop the flow of an ovum towards the uterus, preferably always limiting some part of the oviduct completely to prevent any sperm from passing and also
Wave-like peristaltic movement from the wall of the oviduct into the uterus. Another principle is
<img file="MX353172B_D0012.tif" />
<img file="MX353172B_D0013.tif" />
promote the egg reaching the uterus when it is .. available to cause movement of the egg to c-.i a. ..aba ji út-prn with a downstream peristaltic wave when the risk of pregnancy is not present.
The areas will be indicated in the following:
HYDRAULIC RESTRICTION
When the hydraulic operating device operates, the restriction constricting device or the combined restriction / stimulation unit (d) includes a hydraulic means for adjusting the restriction device.
In one embodiment of the invention, the hydraulic means comprises a reservoir and an expandable / contractable cavity in the constriction device, where the operating device distributes hydraulic fluid from the reservoir to expand the cavity and distributes hydraulic fluid from the cavity to the tank to contract the cavity. The cavity can be defined by a balloon of the constriction device that contacts the wall portion of the tissue of the patient's organ so that the patient's wall portion is limited by expansion of the cavity and is released from contraction of The cavity.
Alternatively, the cavity can be defined by a bellows that displaces an element of
-7INST'.TUTC. U'C ,:; : J, '14 relatively large contraction of the device oÚát'ivó * iuCíí & -<sup>></sup>'<sup>/ </sup>Constriction, for example a large balloon, makes a song with the wall portion so that the patient's wall portion is constricted by contraction of the bellows and released by expansion of the bellows. In this way, a relatively small addition of hydraulic fluid to the bellows causes a relatively large increase in the constriction of the wall portion. Such bellows can also be replaced by properly designed piston / cylinder mechanisms.
When the hydraulic means comprises a cavity in the constricting device, the apparatus of the invention can be designed according to the options indicated in the following.
1) The reservoir comprises a first and second wall portions and the operating device displaces the first and second wall portions relative to one another to change the volume of the reservoir so that fluid is distributed from the reservoir to the cavity or from the cavity to the tank.
a) The first and second tank wall portions are movable relative to each other by at least one magnetic device, a hydraulic device or an electrical control device.
2) The apparatus comprises a fluid line
Λ »
<img file="MX353172B_D0014.tif" />
between the tank and the cavity, where c part of the duct. The conduit and reservoir and the apparatus lack any non-return valve. The reservoir forms a fluid chamber with a variable volume and distributes fluid from the chamber to the cavity by a reduction in chamber volume and withdraws fluid from the cavity by an expansion of chamber volume. The apparatus further comprises a motor for driving the tank, which comprises a movable wall of the tank for changing the volume of the chamber.
In a special embodiment of the invention, the operating device comprises a reverse servo mechanism operatively connected to the hydraulic means. The term reverse servomechanism is to be understood as a mechanism that transfers a large force acting on a moving element having a short stroke, into a weak force acting on another moving element having a long stroke; that is, the inverse function of a normal servomechanism. In this way, minor changes in the amount of fluid in a smaller reservoir can be transferred by the reverse servo mechanism in larger changes and the amount of fluid in a larger reservoir. The reverse servo is particularly suitable for manual operation thereof.
Preferably a tank can be placed,
'J-9IMPI manually operated subcutaneously $$$$ £ pq £ ^ WS? &
'iNI'USÍKJAl' “« A-ÜÍ-jSi · manual of the same.
MECHANICAL RESTRICTION
When the operating device operates mechanically, the restriction device or the restriction / stimulation unit (d), may be non-infallible.
Furthermore, the operating device may comprise a servo system which may include a gear. The term servo system encompasses the normal definition of a servomechanism, that is, an automatic device that controls large amounts of energy by means of very small amounts of energy but that alternatively or additionally encompasses the definition of a mechanism that transfers a weak force that it acts on a movable element that has a long stroke in a large force that acts on another movable element that has a short stroke. Preferably, the operating device operates the constricting device in a non-magnetic and / or non-manual manner. A motor can be operatively connected to the operating device. The operating device may be operable to perform at least one reversible function, and the motor may be capable of reversing the function.
)
<img file="MX353172B_D0015.tif" />
<img file="MX353172B_D0016.tif" />
IMPI
ΓΈ LA PRGTIEi'AI ·
LC u / 3 r fv Jf <C. Λ; ·
COMBINATION OF MEGATOGO CS- ^ HYDRAULIC RESTRICTION DEVICE AND A STIMULATION DEVICE · ------- The present invention provides an advantageous combination of restriction and stimulation devices resulting in a two-stage influence on the flow of ovules in the lumen and the oviduct. In this way, the constricting device can gently constrict the tissue wall of the oviduct wall by applying a relatively weak force against the wall portion, and the stimulation device can stimulate the constricted wall portion to obtain the desired final influence on the flow in the lumen. The phrase "gently constricting a portion of the tissue wall" is to be understood as restricting the wall portion without substantially impeding the circulation of blood in the tissue wall.
According to a first flow restriction option, the control device controls the constriction device to constrict the wall portion, such that flow in the lumen is restricted or stopped and controls the stimulation device to stimulate the portion of constricted wall to cause contraction thereof, such that the flow in the lumen is further restricted or stopped more safely. More precisely, a control device can control the stimulation device in a first mode t 'to stimulate
-Illa wall portion
IΜ> I \
INSTITUTE .· ···· . ;
centt'¿titd<sub>;</sub>a -to · '' further restrict or stop the flu:
for:
a) controlling the stimulation device in a second mode to cease stimulation of the wall portion to increase flow in the lumen; or
b) controlling the stimulation and constriction devices in the second mode to cease stimulation of the wall portion and release the wall portion to restore flow in the lumen.
In this way, both lumen flow control and an apparatus adapted to control lumen flow can be implemented in accordance with the different modalities and characteristics in any combination described herein.
d) Stimulation device only, which can: 1) restrict by stimulation and 2) also create wave-like peristaltic movements if a) stops the flow upstream without completely restricting the oviduct and also b) is capable of causing movement of the ovum down to the uterus with a downstream peristaltic wave:
Preferably, the stimulation device is adapted to stimulate different areas of the wall portion as the restriction device restricts
<img file="MX353172B_D0017.tif" />
<img file="MX353172B_D0018.tif" />
'' V ·, g
<img file="MX353172B_D0019.tif" />
-12 the wall portion and the pacing device device for intermittently and individually stimulating the areas of the wall portion.
This intermittent and individual stimulation of different areas of the wall portion of the oviduct allows the tissue of the wall portion to maintain substantially normal blood circulation during operation of the apparatus of the invention.
Stimulation of different areas can be used to safely close the lumen but can also be used to create a peristaltic wave in the oviduct.
MOVEMENT OF THE OVUM IN THE LUMEN OF THE OVIDUCT
In one embodiment, the restriction device is adapted to constrict the wall portion to restrict or vary flow in the lumen, and the control device controls the stimulation device to progressively stimulate the constricted wall portion, in a downstream direction upstream of the lumen to cause progressive contraction of the wall portion to move the current ovum down into the lumen or to prevent further downward transport of the ovum into the uterus.
<img file="MX353172B_D0020.tif" />
<img file="MX353172B_D0021.tif" />
<img file="MX353172B_D0022.tif" />
-13; / F Ί · 5 T DESIGN OF THE CONTH'Ót 'DEVICE;
The restraining device is preferably controlled from the outside of the body in a manual manner. The restriction device can also be powered. A control device can be provided. The control device suitably controls the restriction device or the stimulation device or a restriction / stimulation unit from outside the patient's body. Preferably, the control device is operable by the patient. For example, the control device may comprise a manually operable switch to turn the constriction / stimulation unit on or off where the switch is adapted for subcutaneous implantation in the patient to be operated manually or magnetically from outside the patient's body.
Alternatively, the control device may comprise a portable wireless remote control which is conveniently operable by the patient to turn the constriction / stimulation unit on and off. The wireless remote control can also be designed for application on the patient's body as a wristwatch. Said type of remote control wristwatch can emit a control signal that follows the patient's body for the response means of the implanted signal of the apparatus.
)
-14IK '·· institute ΔΆ' J¿ LA
In a preferred embodiment of the invention / constriction device it is adjustable to adjust the constriction to the wall portion as desired, where the control device controls the constriction device to adjust the constriction of the wall portion. The control device can control constriction and pacing devices independently of each other and simultaneously. Optionally, the control device can control the stimulation device to stimulate or not stimulate the wall portion while the control device controls the constriction device to change the constriction of the wall portion.
Initially, the constriction device can be calibrated by using the control device to control the pacing device to stimulate the wall portion while controlling the constriction device to adjust the constriction of the wall portion until the desired restriction of flow in the lumen.
REGARDING STIMULATION ONLY OR IN COMBINATION WITH
A RESTRICTION DEVICE
The control device may control the stimulation device to stimulate one or more of the
I areas of
-15 the wall portion to the
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<img file="MX353172B_D0023.tif" />
sequentially stimulate different areas. Furthermore, the control device can control the stimulation device to cyclically spread the stimulation of the areas along the wall portion, preferably according to a certain stimulation pattern. In order to obtain the desired reaction of the tissue wall during stimulation thereof, the control device may control the stimulation device so that, preferably cyclically, the intensity of stimulation of the wall portion varies.
<td>In</td><td>a</td><td>modality</td><td>preferred</td><td>of</td><td>the invention,</td><td>the</td>
<td>device</td><td>of</td><td>control</td><td>controls</td><td>to the</td><td>device</td><td>of</td>
<td>stimulation</td><td>for</td><td>to stimulate</td><td colspan="3">intermittently the areas</td><td>of</td>
the wall portion with pulses that preferably form the pulse trains. At least a first area and a second area of the wall portion areas can be stimulated repeatedly with a first pulse train and a second pulse train, respectively, so that the first and second pulse trains with time is deviated from one another. For example, the first area can be stimulated with the first pulse train while the second area is not stimulated with the second pulse train, and vice versa. Alternatively, the
I
i.
<img file="MX353172B_D0024.tif" />
First and second pulse trains may be relative to each other such that the first and second pulse trains are at least partially overlapping each other.
Pulse trains can be configured in many different ways. In this way, the control device can control the stimulation device to vary the amplitudes of the pulses of the pulse trains, the duty cycle of the individual pulses of each pulse train, the width of each pulse of the pulse trains. pulses, the length of each pulse train, the repetition frequency of the pulses of the pulse trains, the repetition frequency of the pulse trains, the number of pulses of each pulse train and / or the periods of inactive time between the pulse trains. Several pulse trains of different configurations can be used to obtain the desired effect.
In the case of a control device that controls the stimulation device to vary the idle time periods between the pulse trains that stimulate the respective area of the wall portion, it is also possible to control each idle time period between the trains pulse so that it lasts long enough to restore substantially normal blood circulation in the area when the latter is
-17IM Γ T
INSTITUÍ .-- Ο! ··: u ·· j, ·. \ is not stimulated during tierfi ^ Qyínáb ^ periods
An electrical stimulation device suitably comprises at least one, and preferably a plurality of electrical elements such as electrodes, for coupling and stimulating the wall portion with electrical pulses. Optionally, the electrical elements can be placed in a fixed orientation relative to each other. The control device controls the electrical stimulation device to electrically energize the electrical elements, one at a time, or groups of electrical elements to the
Preferably, the control device controls the electrical stimulation device to cyclically energize each element with electrical pulses.
Optionally, the control device may control the stimulation device to energize the electrical elements, such that the electrical elements are energized one at a time in sequence or such that the number of groups of the electrical elements are energized at the same weather. Furthermore, the groups of electrical elements can be energized sequentially, either randomly or according to a predetermined pattern.
The electrical elements can form any pattern of electrical elements.
Preferably the * electrical elements
-18 can form a
<img file="MX353172B_D0025.tif" />
pattern "j $ Jarq a dp¿ pde <> 'electrical elements, where the electrical elements are applicable to the organ patient wall so that the elongated pattern of the electrical elements extends longitudinally along the organ wall and the elements contact the respective areas of the wall portion. The elongated pattern of the electrical elements may include one or more rows of electrical elements that extend longitudinally along the wall of the organ. Each row of electrical elements can form a straight, helical, or zig-zag path of electrical elements, or any form of path. The control device can control the stimulation device to successively energize the electrical elements longitudinally along the elongated pattern of electrical elements in an opposite direction or in the same direction as the flow in the patient's lumen.
According to a preferred embodiment of the invention, the electrical elements form a plurality of groups of elements, where the groups form a series of groups that extend along the patient's organ in the direction of flow of the patient's lumen. The electrical elements of each group of electrical elements can form a path of elements that extend, at least in part, around the organ
-19 of the patient. In a first electrical of each group of
T PT '. · <>>
a a
INSTITUTE .......
alternative,<sup>:</sup>lps. g<sup>;</sup>~! cm.ento.s ^ 'e 1 electrical elements rich_ can ^ form_ more than two paths extend on different sides of elements that are from the patient's organs, preferably substantially transverse to the direction of flow in the patient's lumen . The control device may control the stimulation device to energize the groups of electrical elements at the group site in a random pattern or according to a predetermined pattern. Alternatively, the control device may control the stimulation device to successively energize the groups of electrical elements in the series of groups in an opposite direction or in the same direction as that of the flow in the patient's lumen in both directions to starting from a position substantially in the center of the constricted wall portion. For example, groups of energized electrical elements may form advancing waves of energized electrical elements, as described above; that is, the control device can control the stimulation device to energize the groups of electrical elements, so that the energized electrical elements form two waves of energized electrical elements that advance simultaneously from the center of the wall portion
I «
-20 constrained in two directions
IΜ PI
INSTITUTO MEXICANO opposite ends of the elongated pattern of the electrical elements.
SENSOR
The control device may control the pacing device to change pacing of the wall portion in response to a detectable physical parameter of the patient or a functional parameter of the system. For example, the control device may control the stimulation device to increase the intensity of stimulation of the wall portion in response to an increase in pressure detected in the oviduct, so that flow in the oviduct remains stopped.
Any sensor for detecting a physical parameter of the patient, such as a pressure in the patient's body that is related to the pressure in the oviduct can be provided, wherein the control device controls the stimulation device in response to signals from the sensor. Such a sensor can detect, for example, the pressure in the patient's abdomen, the pressure against the implanted constriction device or the pressure on the tissue wall of a body organ.
For example, a hormone level sensor can be applied where the present invention is used to control the flow of the egg.
i *
-21 INSTITUTO MÍXICA. ·. '·' - '-' • 'JA
RESTRICTION AND / OR STIMULATION DEVICE
SENSOR
As mentioned above, the system may comprise at least one implantable sensor, wherein the control device controls the constriction device and / or the stimulation device in response to sensor signals. Generally, the sensor detects directly or indirectly at least one physical parameter of the patient or at least one functional parameter of the system or at least one functional parameter of a medical implant in the patient.
The system is preferably further adapted to send feedback information from inside the body to the outside of the body to provide feedback related to any functional parameter of the device or physical parameter of the patient.
The functional parameter of the device can be correlated with the power transfer to charge the mentioned internal power source elsewhere.
The functional parameter of the device can be an energy balance, the balance between the received energy and the energy used includes accumulated by the device and the energy balance can also include the balance between the energy reception rate and an energy t
<img file="MX353172B_D0026.tif" />
-22IMPI fNSTITUT: MEXICANDE LA ΓΜ.ιΡΙΕΠαγ · industrial that is used including the accumulation speed.
<img file="MX353172B_D0027.tif" />
Many different kinds of sensors can be used to detect physical parameters.
The control device may comprise an implantable internal control unit that directly controls the constriction device and / or the stimulation device in response to signals from the sensor. The control device may further comprise a wireless remote control adapted to establish control parameters of the internal control unit from outside the patient without mechanically penetrating the patient. At least one of the control parameters, which is adjustable by the wireless remote control, is the physical or functional parameter. Suitably, the internal control unit includes the aforementioned clock mechanism, wherein the wireless remote control is also adapted to set the clock mechanism.
Alternatively, the control device may comprise an external control unit, on the outside of the patient's body to control the constriction device and / or the stimulation device in response to sensor signals.
<img file="MX353172B_D0028.tif" />
Invention, the constriction device is adjustable. In these embodiments, there is an operating device for operating the adjustable constriction device to change the constriction of the patient's tissue wall portion, and the constriction and pacing devices form a constriction / pacing unit. Preferably, the constriction and stimulation devices of the constriction / stimulation unit are integrated into a single piece suitable for implantation. The unit constricting device comprises contact surfaces that are sized to contact a length of a tissue wall portion of a patient's organ, and the unit pacing device comprises a plurality of provided pacing elements and distributed along the contact surfaces. When the control device controls the stimulation device to stimulate the wall portion, the stimulation elements stimulate different areas of the wall portion along the length of the wall portion. The stimulation elements preferably comprise electrical elements, as described above, to stimulate the wall portion with pulses.
I <
-24T 7 Γ m to me r<sup>1</sup>”<sup>7</sup> ''. pfi rl e
F.-.<sup>1</sup> ....;<
electrical. However, in the i:
Other applications of the invention may suitably be used for stimulations such as thermal stimulation.
The operating device operates the adjustable constriction device of the constriction / stimulation unit in a manner that depends on the design of the constriction device, as will be explained in the following embodiment examples.
1) The constricting device comprises at least two elongated clamping elements having contact surfaces and extending along the wall portion on different sides of the member and the operating device operates the clamping elements to clamp the wall portion between the clamping elements to constrict the wall portion of the organ.
2) The constricting device comprises an elongated clamping element having the contact surfaces extending along the wall portion of one side of the member and the operating device operates the clamping element to clamp the wall portion between the holding element and the patient's bone or tissue to constrict the wall portion.
3) The constriction device comprises at least two coupling elements that have the
V
<img file="MX353172B_D0029.tif" />
INSTiTU i '.' . · ·. contact surfaces and placed in sitíb ^ LX- ^ jgefé ^ ej ».
of the organ, and the operating device rotates the coupling elements such that the coupling elements engage and constrain the wall portion of the organ.
4) The constriction device comprises at least two articulated clamping elements that have the contact surfaces and placed on different sides
<td>of the organ,</td><td>and the device</td><td>of</td><td>operation</td><td>move</td><td>the</td>
<td>elements of</td><td>holding one towards</td><td>the</td><td>another for</td><td>hold</td><td>the</td>
<td>portion of</td><td>organ wall</td><td colspan="3">between the elements</td><td>of</td>
clamping, to constrict the wall portion.
5) The constricting device comprises at least two separate clamping elements having the contact surfaces, at least one of the clamping elements is pivoted, so that it can rotate in a plane in which the loop of the constriction member and operation of the device rotates the pivoted fastener to change the size of the constriction opening.
6) The constricting device comprises at least one elongated constricting member having contact surfaces and a forming means for forming the constricting member in at least one substantially closed loop around the organ, where the
I
-26 loop defines operates the constraint member in the operation loop to resize the constraint opening.
The constricting member a band having the elongated surfaces comprises contacting and the operating device operates the band to change the longitudinal extension of the band in the loop to change the size of the constricting opening. The shaping means may shape the constricting member or band into a loop having at least a predetermined size.
<td>6b)</td><td colspan="2">The member</td><td>constriction</td><td>elongate</td><td>is</td>
<td>operable for</td><td>change</td><td>the</td><td>size of the</td><td>opening</td><td>of</td>
<td colspan="2">constriction so</td><td>than</td><td>the surface of</td><td colspan="2">lockdown</td>
<td>circumferential</td><td>external</td><td>of the</td><td colspan="2">constriction device</td><td>I know</td>
it changes or, alternatively, it does not change.
6c) The elongated constriction member is elastic and varies in thickness, as seen in a cross section through it, and is operable to rotate about the longitudinal extension of the constriction member.
6d) The elongated constriction member comprises two substantially or partially semicircular frame elements having the contact surfaces and hinged together, so that the elements
<img file="MX353172B_D0030.tif" />
Sem'Γ -i semicircular can oscillate one in relation ^ á'X 7j © tHo 'from a fully open state in which they substantially or partially form a circle, to a fully folded state in which they substantially form a semicircle.
7) The constriction device is adapted to bend the wall portion of the organ to constrain the latter.
In the modalities indicated in (1) to (7) above, it is important that the constriction device is designed to constrict the length of the tissue wall portion of the patient's organ. For this purpose, the constricting device may include two or more constricting members / elements described to be applied in a row along the length of the wall portion, where the row extends in the direction of flow in the organ oviduct. Preferably, said constraining elements / members are non-infliable and mechanically operable or adjustable.
In the modalities indicated in the foregoing (1) to (7) the operating device can mechanically or hydraulically adjust the constriction device of the constriction / stimulation unit. Furthermore, the operating device may comprise an electrically powered operating device for operating the
I
V
<img file="MX353172B_D0031.tif" />
constriction device. For many applications of the present invention, the device suitably operates the constriction device, so that the area of through flow of the oviduct acquires a size in the constricted state that allows the stimulation device to contract the portion of wall so that the flow in the oviduct stops.
Mechanical operation
When the operating device mechanically operates the constriction / stimulation unit constriction device, it may be non-infallible. Furthermore, the operating device may comprise an active servo system, which may include a gear. The term active servo system encompasses the normal definition of a servomechanism, that is, an automatic device that controls large amounts of energy by means of very small amounts of energy, but that alternatively or additionally encompasses the definition of a mechanism that transfers a weak force acting on a moving member having a long stroke in a strong force acting on another moving member having a short stroke. Preferably, the operating device operates the constricting device in a non-magnetic and / or non-manual manner. A motor can be operatively connected to the operating device. The device ι
-29 /, of operation can be operable for area 1 iz áf-f ροr / 'Ι o' · rte ftos <sup>;</sup>'a reversible function and the motor may be able to reverse the function.
Hydraulic operation
When the operating device hydraulically operates the constriction device of the stimulation / constriction unit, it includes a hydraulic means for adjusting the constriction device.
In one embodiment of the invention, the hydraulic means comprises a reservoir and an expandable / contractable cavity in the constriction device, where the operating device distributes hydraulic fluid from the reservoir to expand the cavity and distribute the hydraulic fluid from the cavity to the tank to contract the cavity.
The cavity can be defined by a balloon of the constriction device that contacts the tissue wall portion of the patient's organ so that the patient's wall portion constricts upon expansion of the cavity and is released upon contraction of The cavity.
Alternatively, the cavity can be defined as a bellows that displaces a relatively large constriction element from the constriction device, for example a large balloon that contacts the wall portion such that the wall portion
<img file="MX353172B_D0032.tif" />
-30t of small patient fluid is constricted in front of the bellows and is released by expansion so a relatively hydraulic addition to the bellows causes a relatively large increase in the constriction of the wall portion. Such bellows can be replaced by a properly designed piston / cylinder mechanism.
When the hydraulic means comprises a cavity in the constriction device, the system of the invention can be designed according to the options indicated in the following.
1) The tank comprises first and second wall portions and the operating device displaces
<td>the</td><td>first and</td><td>second servings of</td><td>wall one</td><td>in</td><td>relation to</td>
<td>the</td><td>another for</td><td colspan="2">change tank volume</td><td>of</td><td>Way that</td>
<td>the</td><td>fluid it</td><td>distributes from the</td><td>deposit to</td><td>the</td><td>cavity o</td>
<td colspan="2">from the cavity</td><td>give the deposit.</td><td></td><td></td><td></td>
<td></td><td>the)</td><td>The first and second</td><td>servings</td><td>of</td><td>wall of the</td>
tank are movable relative to each other by at least one magnetic device, a hydraulic device or an electrical control device.
2) The operating device comprises a pump to pump fluid between the reservoir and the cavity.
2a) The pump comprises a first activation member to activate the pump to pump fluid from »
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-31y. \<sub>v</sub> -. ·;> '^ Χ · instit'. 'Tc?; / 'i ·.: ·' · :: '-. · ·> Λ the deposit to the cavity and a second member' '<sup>t</sup>a®oia »(^ ivafcíij¿<sup>: Yes</sup>'' to activate the pump to pump fluid — from «La— G.avida.-cL · ^ to the reservoir.
2al) The first and second activation members are operable by manual manipulation thereof.
2a2) At least one of the activating members operates when subjected to a predetermined external pressure.
2a3) At least one of the first and second actuating members is operable by a magnetic means, a hydraulic means, or an electrical control means.
2b) The system comprises a fluid conduit between the pump and the cavity, where the reservoir forms a part of the conduit. The conduit and pump lack any non-return valve. The reservoir forms a fluid chamber with a variable volume and the pump distributes fluid from the chamber to the cavity by a reduction in chamber volume and withdraws fluid from the cavity by an expansion of chamber volume. The system further comprises a motor to drive the pump, where the pump comprises a movable wall of the tank to change the volume of the chamber.
In all the modalities indicated in the foregoing 1 to 2b, where the hydraulic medium comprises an expanded cavity in a constriction device, the
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MEXICAN INSTITUTE,. / trtl t'E LA TRCPIC-AO O *. industrial '' e ,.
cavity can be exchanged for a cylinder / piston mechanism to adjust the constriction device. In this case, the operating device distributes hydraulic fluid between the reservoir and the cylinder / piston mechanism to adjust the constricting device.
In a special embodiment of the invention, the operating device comprises a reverse servo mechanism operatively connected to the hydraulic means. The term reverse servomechanism is to be understood as a mechanism that transfers a large force acting on a moving element having a short stroke to a weak force acting on another moving element having a long stroke; that is, the inverse function of a normal servomechanism. In this way, minor changes in the amount of fluid in a smaller reservoir can be transferred to the reverse servo mechanism in larger changes in the amount of fluid in a larger reservoir. The reverse servo is particularly suitable for manual operation thereof.
Preferably, the reverse servo mechanism comprises an expanded servo tank containing servo fluid and a fluid supply tank hydraulically connected to the servo tank to form a closed conduit system for the servo fluid. Servo tank
I
<img file="MX353172B_D0033.tif" />
expandable has a first and second porc: rifaps of ·. papéd-. which are movable one in relation to the other in response to a change in the volume of the expandable servo tank.
According to a first alternative, the first and second wall portions of the servo tank are operatively connected to the hydraulic medium. The reverse servo mechanism distributes fluid between the fluid supply reservoir and the expandable servo reservoir to change the volume of the servo reservoir whereby the hydraulic means is operated to adjust the constriction device.
In accordance with a second alternative, an implantable main reservoir is provided containing a predetermined amount of hydraulic fluid, wherein the reverse servo is operable to distribute hydraulic fluid between the main reservoir and the hydraulic means to adjust to the constriction device. More specifically, the main tank is provided with first and second wall portions operatively connected to the first and second wall portions of the expandable servo tank so that the volume of the main tank changes when the volume of the expandable servo tank changes. In this way, when the reverse servo distributes fluid servo between the
-34ifísti ι -, 'i. . tl ·; -. * fluid supply tank and the servo tank ^ expandable to change the volume of the main tank, the hydraulic fluid is distributed from the main tank to the hydraulic medium or from the hydraulic medium to the main tank. Advantageously, the servo reservoir and main reservoirs are sized such that when the volume of the servo reservoir is changed by a relatively small amount of servo fluid, the volume of the main reservoir is changed by a relatively large amount of hydraulic fluid.
In both alternatives described above, the fluid supply tank can have first and second wall portions, which are movable relative to one another supply to change the volume of fluid tank to distribute servo fluid between the tank of fluid supply and expandable servo tank. The first and second wall portions of the fluid supply tank can be moved relative to one another by manual manipulation, a magnetic device, a hydraulic device, or an electric servo fluid supply tank control device between the expandable servo tank.
In all of to change the volume of fluid to distribute fluid supply and the modalities indicated in
<img file="MX353172B_D0034.tif" />
the above 1 to 2b where the hydraulic medium,; x<sub>;</sub>co ,,, domp-r; §'ridj ^ an expandable cavity in the constriction device or in modalities where the hydraulic means comprises a hydraulically operable mechanical obstruction, the operating device may include the reverse servo mechanism described above. In a further embodiment of the invention, the hydraulic means includes first and second hydraulically interconnected expandable / contractable tanks. The first reservoir is operatively connected to the constriction device, such that the constriction device changes the constriction of the patient's wall portion upon expansion or contraction of the first reservoir. By changing the volume of the second tank hydraulic fluid is distributed between the two tanks so that the first tank expands or contracts. This modality does not require non-return valves in fluid duct communication between the two tanks, which is beneficial to long-term operation of the hydraulic medium.
Alternatively, the hydraulic means may include a first and second hydraulically interconnected piston / cylinder mechanisms instead of the first and second reservoirs described above. The first piston / cylinder mechanism is operatively connected to the constricting device such that the
-36Τ · 7> .. Λ 'T'b Τ χ-ν- - »1 / L /' Ζ \ constriction change the constriction of j5?) 'Tion'.dfe wall, b of the patient before the operation of the first piston / cylinder mechanism. By operating the second piston / cylinder mechanism, hydraulic fluid is distributed between the two piston / cylinder mechanisms so that the first piston / cylinder mechanism adjusts the constraining device.
When the constricting device does not include an expandable / contracting cavity, the constricting device may comprise at least two elongated fasteners having the aforementioned contact surfaces and extending along the wall portion on different sides of the organ. The hydraulic means, which may include the reverse servo mechanism described above, hydraulically moves the elongated fasteners toward the wall portion to constrain the wall portion. For example, the constricting device may have hydraulic chambers in which the clamping elements slide back and forth, and the hydraulic means may also include a pump and an implantable reservoir containing hydraulic fluid. The pump distributes hydraulic fluid from the reservoir to the chambers to move the fasteners against the wall portion, and distributes hydraulic fluid from the chambers to the reservoir to move the r
-37elements of 'Vi v<sup>:</sup> 5NM I <sup>r</sup> > 1 '' »clamping away from the portion xX $ e
MORE THAN A RESTRICTION AREA
The restriction device is independent of which type of type combination is preferable. It comprises more than one restriction area, so it is adapted to change the restriction area over time. This will prevent any damage to the oviduct and will still keep the oviduct closed by preventing any ovum from passing into the lower part of the uterus and thus preventing pregnancy.
In one embodiment, the system comprises a hydraulic restriction device with two or more restriction areas individually connected by two or more tanks with hydraulic fluid, the tanks are adapted to be regulated to move fluid from the tanks individually to each of the areas of restriction connected. It is only possible to use a reservoir if the valves, instead of control over which there is restriction of hydraulic fluid, are operating.
The hydraulic restriction areas are adapted to predetermined, to be restricted for a period of time preferably with some overlap in time, and adapted to first restrict the restriction area to the uterus. In this way the restriction closest to the ovary and then change the area
-38restriction can be maintained throughout
<img file="MX353172B_D0035.tif" />
<img file="MX353172B_D0036.tif" />
present the risk of having someone
<td>change the area</td><td>of</td><td colspan="2">restriction due</td><td>to overlap</td><td>in</td>
<td>the restriction</td><td>and</td><td>too</td><td>because</td><td>that the restriction</td><td>I know</td>
<td>started first</td><td>plus</td><td>near</td><td>of the ovary,</td><td>where the ovule</td><td>he has</td>
<td>been released.</td><td></td><td></td><td></td><td></td><td></td>
The hydraulic restriction areas can be adapted to be regulated by manual manipulation of the same.
The system can also be adapted so that the change in the restriction area causes a peristaltic wave similar to the restriction wave in the direction toward the ovary to prevent the egg from being transported downward to the uterus. This peristaltic wave can be caused by any of different types of restriction devices or combinations described above.
The restriction device can also be adapted to carry out a transport of at least one egg to the uterus upon release of the oviduct. This may be with a peristaltic wave similar to the restriction wave in the opposite direction towards the uterus.
A system to prevent pregnancy can be adapted to restrict a first part of a patient's oviduct area to provide a
<img file="MX353172B_D0037.tif" />
-39IMPIOS restriction and accumulate at least one ovule'.úXí.'b'gráuCTHü ^^ ovary in the oviduct for a predetermined period of time and adapted to restrict a second part of the oviduct and subsequently release the restriction from the first part and also subsequently release the restriction of the second part so that the transport of the ovule is allowed downwards, The uterus or system may be additionally adapted to restrict a third part of the oviduct and release the restriction of the second part, and it may also be additionally adapted to release the restriction of the third part, thereby allowing the transport of the downward ovule, to the uterus, or the system may be adapted to restrict a quarter of the oviduct and release the restriction of the third part. Finally, it may be additionally adapted to release the restriction of the fourth part, thereby allowing the transport of the ovule downward to the uterus.
The number of restriction areas is unlimited except for practical size scopes and the restriction time period is preferably divided by the restriction areas. Any of the restriction areas moves from the ovary and further downwards, towards the uterus stage by stage and in this way any interference with any accumulated ovum is avoided.
<img file="MX353172B_D0038.tif" />
i
<img file="MX353172B_D0039.tif" />
involved in any area satisfies certain overlap in consecutive constraints in use or move in a current towards
I<img file="MX353172B_D0040.tif" />Pl
INSTjT'IT ') //.'XjCANf, of restrictionNL-axfktAL time an, t, rp, la.s the restriction areas up and down and then preferably the movement device is used to move the ovule in the oviduct and prevent any ovum from being compressed in any area of restriction.
Preferably, a hydraulic restriction device only partially limits the oviduct used in combination with a stimulation device to completely close the oviduct. With the stimulation device in this way it is possible to move the restriction area. The hydraulic device may, for example, have the movement function to cause the necessary movements.
Any possible combination
<td colspan="3">In short, preferably</td><td>more of</td><td>two</td><td>areas</td><td>of</td>
<td>restriction</td><td>are used to</td><td>do</td><td>to vary</td><td>the</td><td>area</td><td>of</td>
<td>restriction</td><td>while for</td><td>the</td><td>less</td><td>a</td><td>area</td><td>of</td>
<td>restriction</td><td>it is closed when</td><td colspan="4">the device is on</td><td>the</td>
restriction mode.
If the device is adapted to restrict it will allow the second restriction to be restricted without the first part of the oviduct closest to the ovary,
<img file="MX353172B_D0041.tif" />
ι t
-41I 11 'B 7 interfere with any accumulated ovum. <sup>, nst</sup>pe7aύύ '.' ύ ¡NDvJl x; al
A system adapted to restrict the restriction areas in consecutive order starting from the restriction area, part of the oviduct, closest to the ovary and subsequently restricting any closest to the uterus and also adapted time to the restriction of more than one accumulated permit.
human or area for new area a stage overlap in restriction restrict without interfering
A method for mammalian with any ovum to avoid pregnancy female gender, of a patient comprises the following stages:
Surgically restricting accumulating an oviduct ovum in an oviduct of the post-patient to provide a restriction for at least one ovum released from the ovary a predetermined period of time, in releasing the restriction to admit any oviduct a transport to the uterus, and controlling release from the
In this and the procedures of restriction and exterior of the patient's body.
in other methods the predetermined period of time is adapted to prevent pregnancy and may
A method to place and control two be between and 30 days or more than 30 days.
implanted restraint devices to prevent pregnancy
-42 in a human patient
<img file="MX353172B_D0042.tif" />
feminine comprises the stages of:
insert a needle or tube, or similar instrument into the abdomen of the patient's body,
- use the needle or tube-like instrument to fill the abdomen with gas in order to expand the abdominal cavity, place at least two laparoscopic trocars in the patient's body,
<td> -</td><td>insert</td><td>a</td><td>camera through</td><td>of</td><td>one of</td><td>the</td>
<td>trocars in</td><td>The abdomen,</td><td></td><td></td><td></td><td></td><td></td>
<td> -</td><td>insert</td><td>by</td><td>at least one</td><td colspan="2">tool</td><td>of</td>
<td>dissection to</td><td>through</td><td colspan="3">a trocar and dissect</td><td>An area</td><td>of</td>
at least a portion of the two oviducts of the patient, place two implanted restriction devices in each of the two oviducts, adjust the restriction devices after the operation at a convenient time to avoid becoming pregnant, control the adjustment from the outside the patient's body, and post-surgically restrict the two oviducts to prevent them from becoming pregnant.
Both of the above methods can when they restrict
<img file="MX353172B_D0043.tif" />
t
-43 the oviducts of one a; í
MEXICAN INSTITUTE understand the following eta ^ 'á<sup>1</sup>^^’»<sup>1</sup>™ ^ oviducts to accumulate restrict a patient to at least a first part or area provide a restriction ovule released from the ovary into the oviducts for a predetermined period of time, restrict a second part of the oviduct, release the restriction from the first part , allow shorter restriction periods in the oviduct in each restriction area.
The method also includes the steps of:
release the restriction of the second part, and allow the transport of the ovule downwards to the uterus.
The method may also comprise the stages of:
restrict a third part of the oviduct, release the restriction of the second part, allow the oviduct to have shorter restriction periods in each restriction area.
The method may also comprise the stages of:
release the third party constraint, and
allow the transport of the ovum down into the uterus.
>·
<img file="MX353172B_D0044.tif" />
<img file="MX353172B_D0045.tif" />
ins ^ t; · · -, ··., '
t) E! and>,,
The method may also include laé ^ tapas ^ déirestrict a fourth partg-de-1 - ev j, di * & fa.s> release the restriction of the third part, and allow the restriction periods in the oviduct to be shorter in each restriction area.
The method also includes the steps of:
release the restriction of the fourth part, and allow the transport of the ovule down to the uterus.
In both methods, normally if the first part of the oviduct closest to the ovary is restricted, that is, allowing the second restriction to be restricted without interfering with any accumulated ovum.
Typically these methods comprise having more than two restriction areas, and varying the restriction area while
<td> —</td><td>it keeps</td><td>at least one</td><td>area</td><td>of</td>
<td>restriction</td><td>closed when</td><td>you want restriction.</td><td></td><td></td>
<td>In</td><td>a modality</td><td>preferred</td><td>areas</td><td>of</td>
<td>restriction</td><td>are restricted from</td><td>consecutive order</td><td colspan="2">starting</td>
with the restriction area, part of the oviduct, closest to the ovary posteriorly, restrict any new area one stage
I
-45i and
V.
closest to the uterus, superimpose of a restriction area to restrict accumulated ovum.
A method can
IM i '
INSTITUTE t <
OF THE TT <ri, \;
INej'FcUL time restriction in this manner, moreover without interfering with any single include, regardless of order, variation of the restriction area post surgical to allow the oviduct to recover or to avoid any damage from the restriction while maintaining the oviduct provided restricted or closed.
patient
Another method to avoid the feminine gender includes pregnancy of the following stages:
avoid transporting an egg in an oviduct to the human or mammalian patient's uterus, accumulate at least one egg released from the ovary into the oviduct for a predetermined period of time, by performing a peristaltic-like restriction wave motion of a part of the wall of an ovary of the oviducts preventing the egg from being transported down to the uterus while restricting the oviduct at all times, prevent sperm from reaching the egg during the time the egg accumulates, and
-46IF '' -INSTITUI '·' i ··! / ·; '/ Release the ovum contFdlfñ¿ió ... A¿ surgically from outside the body h<sup>1irnan</sup>Q ·, ...... _ to admit that at least one egg in the oviduct to allow a transport of at least one egg to the uterus.
A method of positioning the anterior device and controlling the implanted device avoiding pregnancy in a female human or mammal patient comprises the steps of:
insert a needle or tube-like instrument into the abdomen of the patient's body, use the needle or tube-like instrument to fill the abdomen with gas thereby expanding the abdominal cavity, place at least two laparoscopic trocars into the body of the patient, insert a camera through one of trocars in the abdomen, insert at least one dissection tool through a trocar and dissect an area of at least a portion of the two oviducts of the patient, place two parts of the implanted device, one in each of the two oviducts, finish the operation and remove the
-47 instruments after
IMPI
MEXICAN INSTITUTE OF THE ΓίΤΙΙΤΛη final suture and post-surgical post-surgical manner:
<img file="MX353172B_D0046.tif" />
adjust the device after the operation at a relevant time to avoid pregnancy, control the fit from outside the patient's body and thus prevent the flow of any ovum by preventing it from reaching the uterus in the two oviducts for a predetermined period of time to prevent pregnancy from occurring thereby accumulating any ovum released from the ovary in one or more of the oviducts by performing a peristaltic-like wave movement of a part of the wall, preventing the ovum from being transported from the oviducts downwards to the uterus, restricting the oviducts at all times, preventing sperm from reaching the ovum during the time the ovule accumulates, and releasing any ovules in the oviducts from outside the body to allow the ovule to normally be transported down to the uterus, when the risk of pregnancy is low.
RESTRICTION MODALITIES
The restraining device may comprise a mechanical restraining device or a
-48 hydraulic restriction or a device
IMPI mSTITUT MEXICANO / ',' ίΡ ·, - · -rpí gf> £ La í '«O, IlLAD íSxsÉLSt de e S tίWtf1 aci-err-As a stimulation device in UOmbi'iia'ijiÚT! - eon ·· - · τΐΐ »
<td>device</td><td>of restriction</td><td>mechanics</td><td>or</td><td>hydraulics</td><td>or</td>
<td>any ot</td><td>ra combination.</td><td></td><td></td><td></td><td></td>
<td>The</td><td>method can</td><td>include</td><td>a</td><td>device</td><td>of</td>
<td>restriction</td><td>hydraulics that</td><td>understands</td><td>a</td><td colspan="2">deposit for</td>
<td>move gas</td><td>or fluid towards</td><td>or from</td><td>the</td><td>device</td><td>of</td>
<td>restriction</td><td>and where</td><td colspan="4">the deposit is placed</td>
subcutaneously to be reached by the patient's hand, for ii. manually move fluid to or from the restriction device.
MOVEMENT DEVICE METHOD
The movement device is adapted to move the ovum outward from a new restricted area coming before a useful new area is restricted if the restriction is to be maintained for a longer period of time and the restriction area therefore needs to move also in the direction towards the ovary in which case the ovule can slide through when it is oppressed by a restriction area and then released.
The movement device may be the same device as the restriction device, adapted to function differently when it restricts or causes movements of the ovum, or it may be a different device
-49 to the restriction device adapted for '^ uhcíonái ^^ CTe different way when restricting or ovule.
The movement device can cause vibration or wave-like movements on the wall of the oviduct and thus cause movements of the egg.
Therefore, another method can be provided to prevent pregnancy of a female human or mammal patient, comprising the following steps:
restraining a first part of an oviduct from the patient to provide a restriction to accumulate at least one ovum released from the ovary into the oviduct for a predetermined period of time, and move the ovule accumulated by the movement device leaving it in the oviduct toward the ovary from the restriction area, allow a second part of the oviduct closest to the ovary to be restricted without interfering with any accumulated ovum,
<td>break free</td><td>the</td><td>restriction</td><td>of</td><td>the</td><td>first</td><td>part,</td>
<td>repeat</td><td>the</td><td>restriction</td><td>of</td><td>the</td><td>first</td><td>part,</td>
<td>break free</td><td>the</td><td>restriction</td><td>of</td><td>the</td><td>second</td><td>part,</td>
allow the oviduct to recover between restriction intervals.
These stages are preferably followed by:
i * <sup>1</sup>
-50Λ
INSTIT'JT ·. i
VE Lr ... ·. ·. and from which • ovule repeat the movement accumulated by the device to move the oviduct toward the ovary from the first restricted area, repeat allowing the second part of the oviduct closest to the ovary to be restricted without interfering with any accumulated ovum, repeat further, release the restriction from the first part, repeat the entire procedure allowing the oviduct to recover between restriction intervals.
Preferably, the restriction areas are also adapted to be varied between three or more areas while always keeping the oviduct closed.
Said movement device may comprise a vibrating device to cause a vibration of at least a part of the wall of the oviduct causing movement of any accumulated ovule, the movement being repeated.
The movement device may comprise a mechanical device or a hydraulic device or a stimulation device or a combined device.
DESIGN OF A CONTROL DEVICE
The control device suitably controls the constriction and / or the drive unit of
-51 stimulation from outside the
<img file="MX353172B_D0047.tif" />
Preferably, the control device 'is operated by the patient. For example, the control device may comprise a manually operable switch for understanding and turning off the constriction / stimulation unit, wherein the switch is adapted for subcutaneous implantation in the patient to be operated manually or magnetically from outside the patient's body. Alternatively, the control device may comprise a portable wireless remote control, which is conveniently operable by the patient to turn the constriction / stimulation unit on and off. The wireless remote control can also be designed for application on the patient's body as a wristwatch. Said type of remote control wristwatch can emit a control signal that follows the patient's body so that a system signal response means is implanted.
When the control device wirelessly controls the constriction / stimulation unit from outside the patient's body, the wireless control function is preferably performed non-magnetic, i.e. the control device controls the constriction device of the stimulation unit. construction / stimulation in a non-magnetic way. The patient can use the remote control to control the
<img file="MX353172B_D0048.tif" />
-52unit of
IMPI ϋΨΠΤΠ'Τ>
,. z /. .<sub>Ί</sub> . z DE La FXür'íívA · · ..
constnccion / stimulation for iNoúarjMiSt
<img file="MX353172B_D0049.tif" />
intensity of stimulation and / or adjust -1st constriction of the wall portion. The wireless remote control may comprise at least one external signal transmitter or transceiver and at least one internal signal receiver or transceiver implantable in the patient.
Preferably, the wireless remote control transmits at least one wireless control signal to control the constriction / stimulation unit. The control signal may comprise a frequency, amplitude, phase modulated signal or a combination thereof and may be an analog or a digital signal, or a combination of an analog and a digital signal. The remote control can transmit an electromagnetic carrier wave signal to carry the digital or analog control signal. Furthermore, the carrier signal may comprise digital, analog, or a combination of digital and analog signals.
Any of the above control signals may comprise wave signals, for example, a sound wave signal, an ultrasound wave signal, an electromagnetic wave signal, an infrared light signal, a visible light signal, a signal ultraviolet light, a laser light signal, a microwave signal, a radio wave signal, an X-ray radiation signal, or a
<img file="MX353172B_D0050.tif" />
· Ι
-53 γ radiation signal.
<img file="MX353172B_D0051.tif" />
WSTITUTO MEXICAHO DE LA PROPIEDAD „,,,. INDUSTRIAL ~
Alternatively, the control signal may comprise an electric or Magnetic field · - »a combined electric and magnetic field.
As mentioned above, the control signal can follow the patient's body to the implanted signal response means of the system.
The control device may include a programmable internal control unit such as a microprocessor, implantable in the patient to control the constriction / stimulation unit. The control device may additionally include an external control unit designed to be outside the patient's body, where the internal control unit is programmable by the external control unit. For example, the internal control unit may be programmable to control the constriction / stimulation unit over time, suitably in accordance with an activity protocol program. The system of the invention may comprise an external data communicator and an implantable internal data communicator that communicates with the external data communicator, wherein the internal communicator supplies data related to the constriction / pacing unit back to the data communicator. External or the external data communicator supplies data to the internal data communicator.
<img file="MX353172B_D0052.tif" />
V ι
<img file="MX353172B_D0053.tif" />
The present invention also ·<sup>11 1</sup> pitíseiiLcf ..... 'tirra' power supply solution for use in connection with the operation of the constriction / stimulation unit. Thus, in a broad sense, the present invention provides a system for controlling the flow of an ovum in an oviduct, formed by a tissue wall of a patient's organ, wherein the system comprises an implantable constriction device to gently constrain a portion of the tissue wall to alter flow in the oviduct, a stimulation device to individually and intermittently stimulate different areas of the wall portion, insofar as the constriction device constrains the wall portion to cause contraction of the wall portion to further influence flow in the oviduct, where the constriction and stimulation devices form an operable constriction / stimulation unit, an energy source and a control device operable from outside the patient's body to control the energy source to release energy for use in connection with the operation of the constriction / stimulation unit. In a simple form of the invention, the power source, such as a battery or accumulator, is implantable in the patient's body.
r
<img file="MX353172B_D0054.tif" />
<img file="MX353172B_D0055.tif" />
IMPI
INSTITUTO M F..X fTAMO WIRELESS ENERGY TRANSMISSION ^ n ^ ÚA
In a more sophisticated form than is preferable, the power source is external to the patient's body and the control device controls the external power source to release wireless power. In this sophisticated form of the invention, the system comprises an energy transmission device that transmits the wireless energy released from outside the patient's body to the inside of the patient's body. Among many things, wireless energy can comprise electromagnetic energy, an electric field, an electromagnetic field or a magnetic field, or a combination thereof, or electromagnetic waves. The power transmission device can transmit wireless energy for direct use in connection with the operation of the constriction / stimulation unit, as wireless energy is transmitted. For example, when an electric motor or pump operates the constricting device, wireless energy in the form of a magnetic or electromagnetic field can be used to direct energy from the motor or pump. In this way, the motor or pump works directly during the transmission of wireless energy. This can be done in two different ways: a) using a patient implantable transforming device to transform i
-56Wireless power into power of a
IMPI
OF THE P «·?> £:> .c And form '^ dff'é ^ re preferably electrical energy and sumiiTT'S'Lrando' 8η»]? «| · Ί» · ”” ··· to the motor or pump with the transformed energy, or b) using wirelessly transmitted energy to power directly to the motor or pump.
Preferably, the wireless energy is in the form of an electromagnetic or magnetic field and is used to directly alter the specific components of the motor or the pump to create kinetic energy to drive the motor or the pump. Such components may include coils built into the motor or the pump or materials altered by magnetic fields or permanent magnets, where the magnetic or electromagnetic field alters the coils to generate a current to drive the motor or the pump, or alters the material or permanent magnets to create kinetic energy to drive the motor or pump.
Preferably, the power transmission device transmits power in at least one wireless signal, suitably a wave signal. The wave signal may comprise an electromagnetic wave signal including one of an infrared light signal, a visible light signal, an ultraviolet light signal, a laser signal, a microwave signal, a radio wave signal, a x-ray radiation signal and a y radiation signal. Alternatively, the wave signal may comprise
Λ
<img file="MX353172B_D0056.tif" />
IMPI
INSTITUTO MEXICANA} DE LA PR PIEDAD INDUSTRIAL a sound wave or ultrasound signal. The signal
<img file="MX353172B_D0057.tif" />
Wireless can be a digital or analog signal or a combination of a digital and analog signal.
TRANSFORMATION OF WIRELESS ENERGY
In accordance with a particular embodiment of the invention, there is provided an implantable energy transformer device for transforming wireless energy in a first manner transmitted by the energy transmission device into energy in a second manner, which is typically different from the energy of the first way. The constriction / stimulation unit is operable in response to energy in the second way. For example, wireless energy in the first form can comprise sound waves, while energy in the second form can comprise electrical energy. In this case, the energy transformation device may include a piezoelectric element for transformation of sound waves into electrical energy. Optionally, one of the energy of the first form of energy and the energy of the second form can comprise magnetic energy, kinetic energy, sound energy, chemical energy, radiant energy, electromagnetic energy, energy
Preferably one of the energy of the first form and photonics, nuclear energy, or thermal energy.
-58IMPI
MEXICAN INSTITUTE
<img file="MX353172B_D0058.tif" />
FROM THE FROHEDAD energy of the second form is non-magnetic, iTO '^' Cíhéf non-chemical, non-sonic, non-nuclear or non-thermic-eia-τ
The power transforming device can operate in a different or similar way from the power transmission device. In a special embodiment, the energy transforming device comprises at least one element, such as at least one semiconductor, that has a positive region and a negative region, when exposed to energy in the first way transmitted by the device energy transmission, where the element is capable of creating an energy field between the positive and negative regions, the energy field produces energy in the second way.
More specifically, the element may comprise an electrical junction element, which is capable of inducing an electric field between the positive and negative regions when exposed to energy in the first way transmitted by the energy transmission device, by what the energy of the second form comprises electrical energy.
The energy transforming device can transform the energy of the first form directly or indirectly into the energy of the second form. An implantable motor or pump to operate the constriction device of the constriction / stimulation unit can be provided, wherein the motor or pump is energized.
-59 by the energy of the second constriction a reversible function can be operable and the
IMPI
MEXICAN INSTITUTE
FAITH THE FR0F1E0A.I>
shape. The device turned<sup>,</sup>'-<sup>i</sup>-of-<sup>></sup>'to perform -by ..... 1 · ο ·· «ηοί» ®'θ motor may be able to reverse function. For example, the control device can change the power polarity in the second way to reverse the motor.
The energy transforming device can directly energize the motor or the pump with the transformed energy , since the energy of the second form is transformed from the energy of the first form. Preferably, the energy transforming device directly operates the constriction / stimulation unit with the energy of the second form in a non-magnetic, non-thermal or non-mechanical way.
Typically, the constriction / stimulation unit comprises electrical components that are energized with electrical energy. Other implantable electrical components of the system may be at least a mounting level protection or at least a constant current protection. Therefore, the energy transforming device can transform the energy in the first way into a direct current or pulsating direct current, or a combination of direct current and pulsating direct current.
Alternatively, the de device
-60I IVÍ PI
INSTITUTO MEXICANO vt-rfííEr '.: r> f la moritOAO energy transformation can transform the<sup>, Nl</sup>é! ¥ ii & * tgra <-Ck the first form in an alt-ornamental current · - <to a combination of direct and alternating current.
The system of the invention may comprise an internal energy source implantable in the patient to supply energy for the operation of the constriction / stimulation unit.
The system may further comprise an implantable switch operable to switch from an off mode in which the internal power source is not in use, to an on mode in which the internal power source supplies power for the operation of the constriction unit / stimulation, and / or to energize implanted electronic components of the system. The switch can be operable by the energy of the first form transmitted by the energy transmission device or by the energy of the second form supplied by the energy transformation device. The switch distribution described reduces the energy consumption of the system between operations.
The internal energy source can store the energy in the second way supplied by the energy transformation device. In this case, the internal power source suitably comprises at least one rechargeable battery, or a combination of the accumulator such as at least one capacitor or so
-61IMFKW-<sup>;</sup>
MEXICAN INSTITUTE ',
Dt LA ίΚί? ΙΊθΛΡ minus a capacitor and at least one battery WffáTga'fe'teT ·
When the internal energy source ua * 'u * Td baturra<sup>1 </sup>Rechargeable, it can be charged only at times convenient for the patient, for example when the patient is sleeping. Alternatively, the internal energy source may supply energy for the operation of the constriction / stimulation unit but not to be used to store energy in the second way. In this alternative, the internal power source may also be a battery, and the switch described above may not be provided.
Suitably, the system of the invention comprises an implantable stabilizer to stabilize the energy in the second way. When the energy of the second form is electrical energy, the stabilizer suitably comprises at least one capacitor.
The energy transformation device can be designed for implantation subcutaneously in the patient's abdomen, chest, or head region. Alternatively, it can be designed for implantation in a hole in the patient's body and below the mucosa or intramuscularly outside the mucosa of the hole.
Even the constriction / stimulation unit in the modalities described above is designed as a single piece, which is more practical for implantation, it is
-62 should note that as an alternative
<img file="MX353172B_D0059.tif" />
, the constriction device and the stimulation device can be 'designed as separate pieces. Any of the constriction and stimulation units described above can alternatively be replaced by two or more separate constriction / stimulation elements which are independently controlled from each other.
When the system is used to control the flow of eggs within a woman's uterus, The system comprises an implantable constriction device to constrict each of the woman's oviducts to limit their passage, and a control device to control said constriction device to constrict the uterine tube so that an ovum that appears in the uterine tube duct is prevented from entering the uterine cavity and to release the uterine tube so that an existing egg in the uterine tube duct is allowed to enter the uterine quality. The constriction device can gently constrict at least a portion of the tissue wall of the uterine tube to restrict the duct therein, and an implantable stimulation device can be provided to stimulate the tissue wall portion, where the delivery device control controls the stimulation device to stimulate the tissue wall portion,
I
-63 as the constriction device constrains
MEXICAN INSTITUTE.
OF THE XDFIEDAD (VJJO INDUSTRIA,!.
'~; the tissue wall portion to cause constriction of the tissue wall portion to further restrict the duct of the uterine tube.
Alternatively, the ovum flow control system comprises an implantable constriction device to gently constrict at least a portion of the tissue wall of each of the female uterine tubes to restrict duct thereof, a device for stimulation to stimulate the tissue wall portion of the uterine tube and a control device to control said stimulation device to stimulate the tissue wall portion, since said constriction device constricts the tissue wall portion to cause constriction in the tissue wall portion to further restrict the duct of the uterine tube to prevent an egg in the uterine tube from entering the uterine cavity.
Alternatively, the ovum flow control system comprises an implantable stimulation device to stimulate a portion of the tissue wall of each of the female uterine tubes and a control device to control the stimulation device to stimulate the portion of tissue wall of the uterine tube to cause contraction of the portion of
<img file="MX353172B_D0060.tif" />
'Titer'iñrr tissue wall so that the duct is restricted to prevent an ovum that — to-er-err-the · uterine tube from entering the uterine cavity and to stop stimulating the tissue wall portion of the uterine tube to allow an existing egg in the duct of the uterine tube to enter the uterine cavity.
The present invention also provides a method of using a system as described above to control a flow of an ovum into the oviduct formed by a tissue wall of a patient's organ, the method comprising:
provide a wireless remote control adapted to control the constriction device and / or the stimulation device from outside the patient's body, and operate the wireless remote control by the patient, when the patient seeks to alter the flow of eggs in the oviduct.
The present invention also provides a method of controlling the flow of an egg in an oviduct formed by a tissue wall of a patient's organ, the method comprises:
a) gently constricting at least a portion of the tissue wall to alter flow in the oviduct, and
<img file="MX353172B_D0061.tif" />
b) to cause contraction of the portion,, aace.d ..... jÍ> .to further alter the flow in the oviduct.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1A illustrates a system according to the invention applied to the oviducts of a patient of the
<td>gender</td><td>female in</td><td>where the</td><td>Devices</td><td>restriction</td>
<td>is it so</td><td>in a state of</td><td>operation</td><td>not restrictive.</td><td></td>
<td></td><td>The figure</td><td>IB is a</td><td>similar view</td><td>to that of the</td>
<td>figure</td><td colspan="2">1A, but where</td><td>Devices</td><td>restriction</td>
<td>is it so</td><td>in a state of</td><td>operation</td><td>of restriction.</td><td></td>
Figure 2A illustrates a system according to the invention with remote control applied on the oviducts of a female patient where the restriction devices are in a non-restrictive state of operation.
FIG. 2B is a view similar to that of FIG. 2A but wherein the restriction devices are in a restrictive operating state.
Figure 3A is a schematic view of a hydraulic operating means with a reservoir placed subcutaneously, suitable for operating the restriction device of the modalities of Figures 1A and Figure IB.
<img file="MX353172B_D0062.tif" />
Figure 3B shows the modality with the constriction device that constricts a _____ wall of tissue from a patient's oviduct.
Fig. 4A is a schematic view of the suitable mechanical operating means for operating the modality constraining device from Fig. 2 to Fig. 11.
Figure 4B shows an embodiment of the figure
4A with the constriction device that constrains a tissue wall of a patient's organ.
Figure 4C shows a modification of the modality of figure 4B.
FIG. 5A, FIG. 5B, and FIG. 5C are cross sections of the embodiment of FIG. 2 showing different operating states with the system applied to a tissue wall of a patient's organ.
Figure 6A, Figure 6B, and Figure 6C are cross sections of a modification of the embodiment of Figure 2 showing different operating states with the system applied to a tissue wall of a patient's organ.
Figure 7A, Figure 7B, Figure 7C, Figure 7D and Figure 7E schematically illustrate different operating states of a general embodiment of a system according to the present invention.
-67 Figure 7F, Figure
<img file="MX353172B_D0063.tif" />
INSTITUTE mF.XiCáh
7G and the <sup>l</sup>‘<sup>TO</sup>'N ^ gür'a<sup>>,</sup>^ ¿Il · ^ 'illustrate different operating states of --- a modification of the general modality.
Fig. 7E, Fig. 7K and Fig. 7L illustrate an alternative mode of operation of modifying the general embodiment.
Figure 8A is a pulse / time diagram showing the electrical stimulation pulses generated by the system of the invention to stimulate a tissue wall of a patient's organ.
Fig. 8B is a pulse / time diagram showing a modification of the electrical stimulation shown in Fig. 8A in which pulses of mixed frequency and / or amplitudes are used.
Figure 8C and Figure 8D show two pulse / time diagrams, respectively, depicting electrical stimulation of two different areas of the tissue wall with pulses that form the pulse trains.
Figure 9A is a longitudinal cross section of an embodiment of the system of the invention including a thermal stimulation device, wherein the system is to constrict a tissue wall of a patient's oviducts.
Figure 9B is the same embodiment of figure
9A with the thermal stimulation device activated.
β «
-68íNSTjn ·· ': · - 4 dí r .....
Figure 10A is a schematic view of the inflatable constriction device, hydraulically, for use in accordance with the invention.
Fig. 10B is the same embodiment as that shown in Fig. 10A with the inflated constriction device.
Fig. 11A, Fig. 11B, Fig. 11C and Fig. 11D are block diagrams illustrating four different principles for the hydraulic operation of the construction device shown in Fig. 10A.
Fig. 12 is a cross sectional view of a reservoir having a variable volume controlled by a remote control motor.
Fig. 13A and Fig. 13B are perspective views of a reverse servo in accordance with a particular embodiment of the hydraulic operating principle shown in Fig. 11C.
Figure 14 is a schematic view of another hydraulically operable constriction device for use in accordance with the invention.
<td>The</td><td>figure 15A</td><td>illustrates the</td><td>device</td><td>of</td>
<td>constriction</td><td>of figure 34</td><td>in a state</td><td>constrained.</td><td></td>
<td>The</td><td>figure 15B</td><td>illustrates the</td><td>device</td><td>of</td>
<td>constriction</td><td>of figure 14</td><td>in a state</td><td>released.</td><td></td>
A i
The figure
-6916 is a
<img file="MX353172B_D0064.tif" />
schematic illustrating a gellOldl modality <sup>1</sup> dtri — si 5 emme of the invention in which energy is transferred to the energy consuming components of the system implanted in the patient.
From Figure 17 to Figure 28 are schematic block diagrams illustrating twelve modalities, respectively, based on the general modality shown in Figure 37, where wireless energy is transmitted from outside the patient's body to the components that consume energy from the system implanted in the patient.
FIG. 29 is a block diagram illustrating the control components of an embodiment of the invention.
Figure 30 is a schematic view of exemplary circuitry of an embodiment of the invention in which wireless power is turned into current.
DETAILED DESCRIPTION OF THE INVENTION
With reference to the drawing figures, similar reference numbers designate identical or corresponding elements in the various figures.
Figure 1A and Figure IB illustrate a first modality of system to treat a female patient to avoid pregnancy applied on the
<img file="MX353172B_D0065.tif" />
oviducts 31a, 31b from a patient of 960 ^ 02 / .0 ^ 160: 1130 .., ^ 05 ^ fasteners 5, 6 of a restriction or constriction device 2 constrain oviducts 31a, 31b (for the sake of clarity, housings not shown and fasteners 5, 6 have been exaggerated). In this embodiment, a control device includes a push button, implanted subcutaneously that is manually activated by the patient into their on and off positions. This control device will be described in greater detail in the following with reference to Figure 3A and Figure 3B. Said push button, operable manually, can also provide in combination with a remote control as an emergency button to allow the patient to stop the operation of the system in case of emergency or malfunction. Said remote control will be described in the following with reference to Figure 2A and Figure 2B. The system may also be fully manually controlled by manual manipulation or, for example, from a hydraulic reservoir controlling a hydraulic restriction device as described in Figure 3A to Figure 3D or Figure 15Ά and Figure 15B or Figure 10A and Figure 10B or anywhere from Figure 11A to Figure 11D. Note that only a manually moving fluid reservoir such as those shown in Figure 3C and Figure 3D can be used to
-71I? P TV -Á. '<sup>?</sup> ', T ..:. 7 adjust the restraining device. The ^ epeísit · ©<sub>(</sub>se-j can: Control such that the reservoir volume change will be stable after manual reservoir handling has been performed. In this particular case an observation device is shown, but many different ways can be used. A small amount of fluid in the reservoir can also cause a larger movement of the restriction device as described in some of the above modalities.
Figure 2A and Figure 2B illustrate an alternative modality applied to the oviducts 31a, 31b of a female patient. The fasteners and 6 of the constriction device 2 constrict the oviducts 31a and 31b (for clarity, the housing is not shown and the fasteners 5 and 6 are exaggerated). In the embodiment, a control device includes an external control unit in the form of a portable wireless remote control 32 and an implanted internal control unit 33 which may include a microprocessor, to control the constriction and stimulation devices. Remote control 32 is operable by the patient to control internal control unit 33 to turn the restraining device on and off.
The internal control unit 33 controls a «
i «
-72Ιρ, Λ iNSTin impla implanted operating device 34 fasteners 5, 6. An implanted power source 35 such as a rechargeable battery powers the operating device 34. The internal control unit 33 which can be implanted subcutaneously or in the abdomen, can also function as an energy receiver, that is, to transform wireless energy into electrical energy and charge the implanted energy source 35 (rechargeable battery) with the electric power.
An implanted sensor 36 detects a physical parameter of the patient such as temperature, where the internal control unit 36 controls the constriction device 2 and / or the stimulation device 3 in response to signals from sensor 36. In this embodiment, sensor 36 is a hormone level sensor, where the internal control unit 33 controls the constriction device and / or stimulation device to change the constriction of the patient's oviducts 31 in response to the sensor 36 detects a predetermined value of the measured value. For example, the control unit 33 may control the constriction device and / or the stimulation device to increase the constriction of a patient's oviduct 31 in response to the sensor detecting an increased or decreased hormone concentration. Alternatively or in combination
<img file="MX353172B_D0066.tif" />
-73__ institute 'ί, / Ο'-ϊ remote control 32 controls wlAr ^ rsi!> Osibi5ro.'t7 iNrusTMAL deconstriction and / or pacing device in response to sensor 36 signals, in the same way as the internal control unit 33.
Remote control 32 may be equipped with a means for producing an indication, such as a sound signal or displayed information, in response to signals from sensor 36, when patient voltage is required for such an indication indicating release of the oviducts with base at the sensor input. The patient can use the remote control to control the constriction device or the stimulation device to pump eggs through the patient's oviducts.
Fig. 3Ά and Fig. 3B show a suitable hydraulic operating means for operating the constriction device in the modalities described above with reference to Fig.
1A and figure
IB.
Specifically, Figure 3A Figure
3B show the system of figure 1A and figure IB provided with said means for hydraulic operation of the constriction device 2. In this way, the housing 1 forms two hydraulic chambers 22a and 22b in which the two clamping elements 5 and 6 are slidable back and forth relative to the tubular tissue wall portion 8 of a patient's oviducts. The means of
I>
-74 hydraulic operation includes a tank
11·^’··'-
2^<sup>NS1</sup>¿Ib.add i-blé tal ·
I.OUSTa ·. ' L · as an elastic balloon, containing hydraulic fluid, lines 24a and 24b between the reservoir and the hydraulic chambers 22a and 22b and a two-way pump 25 for pumping the hydraulic fluid into lines 24a and 24b. Deposit 23 is placed subcutaneously between the skin, shown with a solid line in the figure, and the facial / muscular layer normally, shown with a broken line. Control device 4 controls pump 25 to pump hydraulic fluid from reservoir 23 to chambers 22a and 22b to move clamping elements 5 and 6 against wall portion 8 whereby tubular wall portion 8 is constricted, See Figure 3B and for pumping hydraulic fluid from chambers 22a, 22b to reservoir 23 to move fasteners 5 and 6 away from wall portion 8 whereby tubular wall 8 is released, see Figure 3A.
Alternatively, the modality of the figure
3A and Figure 3B can be manually operated by applying a manually operable hydraulic medium, suitable for distributing the hydraulic fluid between the expanded tank 23 and the hydraulic chambers 22a and 22b. In this case, pump 25 is skipped. Also in this case the control device 4 is only for manual handling of the tank. An example is shown in Figure 3C and 3D. In ί
*
<img file="MX353172B_D0067.tif" />
INSTIR this particular modality is supplied with a ^^^^. ..Small than the tank wall (4b) but this is the only one of many ways to solve this modality.
Figures 4A and 4B schematically show a mechanically operable embodiment of the invention comprising an open-ended tubular housing 26 applied to the tubular tissue wall portion 8 of a patient's organ, a constriction device 27 placed in the housing 26 and a control device 4 for controlling the constriction device 27. A stimulation device (not shown) as described above is also provided in housing 26. Constriction device 27 includes a holding member 28 which can be moved radially in tubular housing 26 towards and away from the portion 8 of the tubular wall between a retracted position, see Figure 4A and a clamping position, see Figure 4B in which the clamping element 28 gently constrains the tubular wall portion 8. The mechanical operating means for mechanically operating clamping element 28 includes an electric motor 29 attached to housing 26 and a telescopic device 30 which is driven by motor 29 and operatively connected to clamping element 28. Control device 4 controls electric motor 29 to expand telescopic device 30 to
-76 move clamping element 28 against
<img file="MX353172B_D0068.tif" />
IN5TIT · MEXION
Í'F IA fi./f-IEI Al), iNLlJSTRlAL the upper wall, so that the portion 8 of tubular wall 'constrains, see figure 4B and controls the motor 29 to retract the telescopic device 30 to move the element 28 holding it away from the wall portion 8 whereby the wall portion 8 is released, see Figure 4A.
Alternatively, motor 29 can be omitted and telescopic device 30 can be modified for manual operation, as shown in Figure 4C. In this way, a spring 30a can be provided which acts to keep the telescopic device 30 expanded to force the clamping member 28 against the wall portion 8. The mechanical operating means may include a subcutaneously implanted lever mechanism 29a that is operatively connected to the telescopic device 30. The patient can push the lever mechanism 29a through the patient's skin 29b to pull the telescopic device 30 against the action of the spring 30a to the retracted position of the telescopic device 30, as indicated by broken lines. When the patient releases the lever mechanism 29a, the spring 30a expands the telescopic device 30 whereby the holding element 28 is forced against the wall portion 8.
Figures 5A to Figure 5C illustrate in
-77principle the function of the system of the figürá¡MfÁcúahdóiiPÍ * 'system is applied to a portion 8 of a.-Puajiari- ^ tubular tissue of the oviduct of a patient. In this way, Figure 5Ά shows the system in a non-clamping state, in which the clamping elements 5, 6 are in their retracted positions and the wall portion 8 extends through the open ends of the housing 1 without they are constrained by clamping elements 5 and 6. Figure 5B shows the system in a clamping state in which the clamping elements 5 and 6 have been moved from their retracted positions to their clamping positions in which the clamping elements 5 and 6 gently constrain the wall portion 8 to a constricted state, in which the circulation of blood in the constricted wall portion 8 is substantially unrestricted and the flow in the oviduct of the wall portion 8 is restricted. Figure 5C shows the system in an optional stimulation state in which the clamping elements 5 and 6 constrain the wall portion 8 and the electrical elements 7 of the stimulation device 3 electrically stimulate different areas of the wall portion 8 in a manner that the wall portion 8 contracts (thickens) and closes the oviduct.
When the system is in its optional stimulation state, it is important to stimulate the «
• esencialmente essentially maintain their is — Tratrrradre ^ · properties over time to prevent areas from being damaged. Accordingly, the control device 4 controls the stimulation device 3 to intermittently stimulate each area of the wall portion 8 for successive periods of time, where each time period is short enough to maintain satisfactory blood circulation over time. the area. Furthermore, the control device 4 controls the stimulation of the areas of the wall portion 8 so that each area that is not currently stimulated restores a substantially normal blood circulation before it is stimulated again. To maintain the stimulation effect over time, i.e. to keep the oviduct closed by keeping the wall portion 8 contracted, the control device 4 controls the stimulation device 3 to stimulate one or more of the areas at a time and to shift stimulation from one area to another over time. The control device 4 can control the stimulation device 3 to cyclically propagate the stimulation of the areas along the tubular wall portion 8, for example, according to a determined stimulation pattern. To obtain the desired reaction of the tissue wall for <
<img file="MX353172B_D0069.tif" />
<img file="MX353172B_D0070.tif" />
institute:
stimulation thereof, the stimulation device can control the stimulation device for, preferably cyclically, the intensity of stimulation of the wall portion 8 varies.
It will be appreciated that the fully restricted state shown in Figure 5C can be obtained
<td>by means</td><td>purely</td><td colspan="2">mechanics that</td><td>don't involve</td>
<td>stimulation</td><td>electric.</td><td></td><td></td><td></td>
<td>The</td><td>figure 6A</td><td>to</td><td>the figure</td><td>6C shows another</td>
<td>modality of</td><td>the invention</td><td>the</td><td>which includes</td><td>accommodation 9</td>
tubular and three elongated clamping elements 10a, 10b and
10c, which can be moved radially in the tubular housing 9 towards and away from the central axis thereof between the retracted positions, see figure 6A and the clamping positions, see figure 6B. The three clamping elements lOa-lOc are symmetrically placed around the central axis of the housing 9. The stimulation device of this embodiment includes electrical elements lia, 11b and 11c that form a series of groups of elements that extend longitudinally along the elongated holding elements lOa-lOc, where the electrical elements lla-llc of each group of electrical elements forms a path of three electrical elements lia, 11b and 11c extending circumferentially around the central axis of the «
IΜ PI
MEXICAN INSTITUTE 'and
PE LA l'ROFIEOAD housing 9. The three electrical elements • 'T ^ S' ^ llc '^ - Se' each group are placed on the three elemen-trys<sup>1</sup> clamping lOa-lOc, respectively. In this way, the path of the three electrical elements lla-llc extends around the patient's organ. Of course, the number of lla-llc electrical elements in each electrical element path may be greater than three, and several parallel rows of lla-llc electrical elements may form each electrical element path.
Figure 7A, Figure 7B, and Figure 7C schematically illustrate different operating states of a system generally designed in accordance with the present invention, when the system is applied to a wall portion of an oviduct called BO. The system includes a constriction device and a stimulation device which are called CSD and a control device called CD to control the CSD constriction and stimulation devices. Figure 7A shows the system in an inactive state in which the constricting device does not constrain the BO organ and the stimulating device does not stimulate the BO organ. Fig. 7B shows the system in a constricted state in which the CD control device controls the constricted device to gently constrain the organ wall portion BO to a state
I constrained in which the circulation of<sup>Λ</sup> Constricted wall portion is epfincj glmpnt.e__ restricted and flow in the oviducts of the wall portion is restricted. Fig. 7C shows the system in a pacing state in which the CD control device controls the pacing device to stimulate different areas of the constricted wall portion so that almost the entire wall portion of the BO organ contracts (thickens) and closes the oviduct.
Figure 7D and Figure 7E show how stimulation of the constricted wall portion can be cyclically varied between a first stimulation mode in which the left area of the wall portion (see Figure 7D) is stimulated while the right area of the wall portion is not stimulated, and a second stimulation mode in which the area is stimulated
<td>right of the wall portion (</td><td>see</td><td>the figure</td><td>7E)</td>
<td colspan="2">while the left portion area</td><td>wall no</td><td>I know</td>
<td>stimulates, in order to maintain</td><td>on</td><td>time</td><td>a</td>
<td colspan="4">satisfactory blood circulation in the wall portion</td>
<td>constrained.</td><td></td><td></td><td></td>
<td>It should be noted that</td><td>modes</td><td colspan="2">stimulation</td>
<td>shown in figure 7D</td><td>and in</td><td>the figure</td><td>7E</td>
<td>they are only an example of</td><td colspan="2">beginning of how</td><td>the</td>
-82 portion of stimulated.
Serving
I<img file="MX353172B_D0071.tif" />PI
INSTITUTO Mf.YJCAKO,, ~ D £ LA l'ROfUO, \ n constricted wall of the organ BO ^ i-pae ·
Simultaneously
<img file="MX353172B_D0072.tif" />
this way, more than two areas?<sup>0</sup> Constricted wall hp can be stimulated in successive stimulation cycles. In addition, groups of constrained areas can be
The figure illustrates modification states of Figure 7A up to constriction and different from the stimulating portion successively.
7F, the figure of operation general modality of wall
7G and the other than Figure 7E, where Figure 7H CSD pacing of one is shown from the devices include several separate constraint / pacing elements, here three elements CSDE1, CSDE2 the element CSDE1 in constraint and CSDE3. Figure 7F a first state of and stimulate the organ that the BO organ oviduct is two other elements CSDE2 and CSDE3
7G shows how the state closes the elements of which state organ operation next oviduct
CSDE1 and way the organ shows how operation is
BO so closes while they are inactivated. CSDE2 element is activated
BO while
CSDE3 are inactivated. CSDE3 element in an operation is activated
BO closes while in one way it figures second than the other two figure 7H shows next third so that the oviduct of which the other two elements
CSDE1 and CSDE2 are inactivated.
By displacement between
<img file="MX353172B_D0073.tif" />
-83ΐΝ <σιτυ'ΐ.ο / w:: ·? '·' Α first, second and third states of opera ^^^ -. ^ Ya- ^ s .- ^ a ^ and randomly according to a predetermined sequence, the different portions of the organ may be temporarily constricted and stimulated while keeping the organ's oviduct closed thereby minimizing the risk of organ damage. It is also possible to activate the CSDE1-CSDE3 elements successively along the organ's oviduct to move fluids and / or other body material in the oviduct.
Fig. 71, Fig. 7K and Fig. 7L illustrate an alternative mode of operation of modifying the general modality. Thus, figure 71 shows how the CSDE7 element in a first operating state is activated to constrict and stimulate the BO organ so that the BO organ oviduct closes while the other two elements, CSDE2 and CSDE3 are activated to constrict but not to stimulate the BO organ so that the BO organ oviduct does not close completely where the CSDE2 and CSDE3 elements engage the BO organ. Figure 7K shows how the CSDE2 element in a second second operating state is activated to constrict and stimulate the BO organ so that the BO organ oviduct is closed while the other two elements, CSDE7 and CSDE3 are activated to constrain but not to stimulate the BO organ so t
-84 1
........... _ Jr that the BO organ oviduct does not close compleébám'éhte where elements CSDE1 and CSDE3 dock- & ft ~ eeft --el
<td>BO. The figure</td><td>7L shows how the CSDE3 element in</td>
<td>a following</td><td>third operating state is activated to</td>
<td>constrain and</td><td>stimulate the BO organ so that the</td>
The BO organ oviduct closes while the other two elements, CSDE1 and CSDE2 are activated to constrict but not to stimulate the BO organ so that the BO organ oviduct does not close completely where the CSDE1 and CSDE2 elements are coupled by the BO organ. By shifting between the first, second, and third states of operation, either randomly or according to a predetermined sequence, different portions of the organ can be temporarily stimulated while keeping the organ's oviduct closed thereby reducing the risk of damage to the organ. organ. It is also possible to activate the stimulation of the CSDE1-CSDE3 elements successively along the oviduct of the BO organ to move fluids and / or other body material in the oviduct. This modality, with a combination of a partially mechanical or hydraulic restriction system and a stimulation system that varies the stimulation position, is preferably used when one wishes to close the oviduct for a longer period of time. The system is energy efficient since preferably only the stimulation t
-85 mexican institute <- _ t;
and threw what tólüáS · 'needs to be changed position oviducts recover until the situation returns to.
same position again. If the restriction areas are placed closer to each other and the mechanical or hydraulic restriction is possibly continuous, a peristaltic-like wave can be created in any direction in the oviduct. If the restriction is moved in consecutive order starting with the restriction closest to the ovary, no ovules will be compressed in the restriction area. If the restriction is moved in another direction toward the uterus, the motion device can be used to move any egg away from any new coming restriction area. Said movement device may be a hydraulic or mechanical partial restriction device that causes movements in the wall of the oviduct before the stimulation device closes the area.
Figure 8B is a pulse / time diagram showing a modification of the electrical stimulation shown in Figure 8A. Therefore, the pulse combination of Figure 8A is mixed with a pulse train combination that has a relatively high, high frequency / low amplitude pulsed first pulse PTL train that appear simultaneously with the positive PL pulse of the combination pulse of Figure 8A and a relatively shorter second pulse train PTS of
-86J 1¾ 'PI
INSTIT! Π or G py: /./ · '..¿ν, Ο. high frequency / low amplitude thatNDu.ljjALap'aréSS '' 'simultaneously with the negative pulse P5 na? j-on — pulse is shown in Figure 8A. As a result, the high frequency / low amplitude pulse trains PTL and PTS are superimposed on the positive and negative pulses PL and PS of Figure 8A, as illustrated in Figure 8B. The pulse configuration of FIG. 8B and variant thereof is beneficial for use in connection with stimulation of particular human organs in order to obtain the desired stimulation effect.
Preferably, the electrical pulses form pulse trains, as illustrated in the pulse / time P / t diagram of Figure 8C and Figure 8D. The pulse / time diagram P / t of FIG. 9A represents an individual area of the wall portion of a tubular organ of a patient which is stimulated with a pulse train 18A. The pulse train 18A includes three initial negative pulses, each of which is short in duration and high in amplitude (voltage), and a long duration, low amplitude positive pulse following the negative pulses. After a delay to enable the organ area to restore substantially normal blood circulation, pulse train 18A is repeated.
The pulse / time diagram, P / t of Fig. 8D represents another individual area of the wall portion the
<img file="MX353172B_D0074.tif" />
which is stimulated with a pulse train 18B same configuration as the pulse train 18A. pulse trains 18A and 18B move relative to each other so that they partially overlap each other to ensure that the constricted wall portion is always stimulated for contact, as desired.
Figure 9A and Figure
9B show another embodiment of the invention that controls the flow of blood in a blood vessel 19 comprising a constriction device with two holding elements 20a and 20b, a stimulation device in the form of two thermal stimulation elements 21a and 21b integrated in the clamping elements 20a, 20b, respectively, and a control device 4 for controlling the clamping elements 20a, 20b and the stimulating elements 21a, 21b. The fastening elements 20a and 20b can be moved towards and away from each other in the same way as described above in connection with the embodiment according to figure 5Ά to figure 5C. The thermal stimulation elements 21a and 21b, which may include Pertier elements, are positioned on the fastening elements 20a and 20b such that the thermal elements 21a are oriented towards the thermal elements 21b. Fig. 11A shows how the clamping elements 20a and 20b constrict the blood vessel 19 so that the blood flow is restricted. Figure 11B shows how
JT <Ti. lN3T; 7-.r0> '<sup>?</sup> '': '· The device $ it.ivp <sub>:</sub> Four . control controls the thermal imputation elements
21a and 21b to cool the wall of the blood vessel 19 so that the wall contracts and closes the blood vessel.
To free the blood vessel, the device controls the thermal stimulation elements 21a and 21b to heat the wall of the blood vessel 19 so that the wall expands.
Figures 10A and Figure 10B show a hydraulically operable elongated constriction device in the form of a band
2 having an expandable / contractable cavity 73 which is in fluid communication with an adjustable reservoir containing hydraulic fluid.
Figure 10A illustrates when the band is in a non-constricted state, while Figure 10B illustrates when the band is in a constricted state in which cavity 73 is expanded by hydraulic fluid supplied by reservoir 74.
Figure 31A, Figure 31B, Figure 31C, and Figure 31D are block diagrams of four differently operated hydraulic constraint devices.
Figure 31A shows band 72 of figure 10A, cavity 73 of which is in fluid communication with reservoir 75. Figure 31B shows the embodiment of figure 10A in which cavity 73 of band 72 is in ' i
I fluid communication with the
IM '"
1NST1T '; - · .:
D. ·. THE :
tank 7 4 via a sparks Ltiv.o ... a pump 7 6 of «de.s« —aiaa .., figure 11C shows an operation device in the form of a reverse servo system with a first closed system that controls a second system. The reverse servo system comprises an adjustable fluid supply reservoir 77 and an adjustable servo reservoir 78. The servo reservoir 78 controls a larger, adjustable reservoir 79 which, relative to the band 72 applied around a portion of the tubular tissue wall of a patient's organs, varies the volume of the band cavity 73 72 which in turn causes the constriction of the wall portion to vary. FIG. 11D shows an embodiment identical to that of the embodiment of FIG. 11C with respect to omitting a larger reservoir 79. Instead, servo reservoir 78 is in fluid communication with band cavity 72.
In all of the above embodiments in accordance with FIG. 12A through FIG. 10B, pacing devices may be provided to form constriction / pacing units in which pacing devices include a multiplicity of electrical elements 7 (indicated from figure 12A to figure
15, from figure 18, figure 20 to figure 23 and from figure 26 to figure 11B) placed in the constriction devices.
-90IMPI
MEXICAN INSTITUTE OF INDUSTRIAL PROPERTY
<img file="MX353172B_D0075.tif" />
Fig. 12 is a cross sectional view of a fluid supply device including a bellows reservoir 80 including a chamber 81, the size of which is variable by an operating device comprising a remotely controlled electric motor 82. Reservoir 80 and motor 82 are placed in housing 83. Moving a large wall 84 causes chamber 81 to vary. Wall 84 is secured to a nut 85 which is threaded onto a rotatable spindle 86. Spindle 86 is rotated by motor 82. A battery 89 placed in housing 83 powers motor 82. A signal receiver 90 for controlling motor 82 is also placed in housing 83. Alternatively, battery 89 and signal receiver 90 can be mounted in a separate location. Motor 82 can also be powered with energy transferred from the transmitted signals.
When applicable, the fluid supply device of Figure 12 can be used to supply hydraulic fluid for the operation of the constriction devices described in this specification. For example, the fluid supply device of Figure 12 can be replaced by reservoir 74 in the mode according to Figure 10A.
Figure 13A and Figure 13B show a
<img file="MX353172B_D0076.tif" />
instit-j r-.
reverse servomechanism that includes a Pó'j'iawlfíñto ·. ^ ... 9-l -.--<sup>x </sup>rectangular and an intermediate wall 92, which is movable in the housing 91. A relatively large and substantially cylindrical bellows deposit 93 is placed in the housing 91 and is attached to the movable intermediate wall 92. Another cylindrical bellows tank 94 which is substantially smaller than tank 93, is placed in housing 91 on the other side of intermediate wall 92 and is also attached to wall 92. The small bellows tank 94 has a fluid supply tube 95 and the large bellows device 93 has a fluid supply tube 96.
Referring to Fig. 13A when a small amount of hydraulic fluid travels through the supply tube 95 to the small bellows tank 94, the small bellows tank 94 expands and pushes the movable intermediate wall 92 toward the bellows tank 93 big. As a result, the large bellows reservoir 93 is contracted by the intermediate wall 92, whereby a large amount of hydraulic fluid is forced out of the large bellows reservoir 93 through the supply tube 93, as shown in Figure 13B.
<td>By</td><td>example,</td><td>servomechanism</td><td>reverse</td><td>of</td><td>the</td>
<td>figure 13A and</td><td colspan="2">Figure 13B can be</td><td>use</td><td>in</td><td>the</td>
<td>modality of</td><td>the figure</td><td>11C, where the</td><td>Deposit</td><td> 94</td><td>of</td>
I
<img file="MX353172B_D0077.tif" />
ΙΝβΤΠΌΤΟ Α-Α'ΑΑ'Α, - 7.
Small bellows corresponds to a servo depositt ^<sup>L</sup>*^',<sup>!</sup>ip) gqü ^ ¿p¿-yi.> the large bellows tank 93 corresponds to a large tank 79. Furthermore, the reverse servo mechanism of Figure 13A and Figure 13B can be used in the embodiment of Figures 10A and Figure 10B, where the small bellows tank 94 is connected to the adjustable tank 74 and the bellows tank 93 Large connects to cavity 73 of band 72.
Fig. 14 schematically shows a hydraulically operable constriction device 97 of the system of the invention which is similar to the embodiment shown in Fig. 10A, except that the hydraulic system is designed differently. In this way, the constriction device 97 includes a relatively small unfavorable cavity 98 which is in fluid communication with the reservoir 99 containing hydraulic fluid and a relatively large cavity 100, which is movable by the small cavity 98. The small cavity 98 is adapted to displace the large cavity 100 to constrict the tubular wall portion of the patient when the small cavity 98 is inflated and to displace the large cavity 100 to release the wall portion when the small cavity 98 is deflated. In this way, a relatively small addition of hydraulic fluid from reservoir 99 to small cavity 98 causes an increase
-93INSTIT'il 3 and? '.and V; relatively large in wall constriction. - —- Large cavity 100 is defined by a contraction element in the form of a large balloon 101 which can be connected to an injection port (not shown) for volume calibration of large cavity 100. Adding fluid or removing fluid from the injection port with the help of a syringe calibrates the volume of the balloon 101. The small cavity 98 is defined by a small bellows 102 attached to the annular frame 103 of the constriction device 97 and the opposite end is attached to the balloon 101.
Fig. 15A and Fig. 15B schematically illustrate the operation of the constriction device 97 when the annular frame 103 is applied around the tubular wall portion of the patient's organ. Referring to Figure 15A, when the stick cavity 98 deflates, the bellows 102 pushes the balloon 101 inward into the annular frame 103 so that the constriction device 97 constricts the wall portion. Referring to FIG. 15B, when the small cavity 98 is inflated, the bellows 102 pulls the balloon 101 out of the annular frame 103 so that the constriction device 97 releases the wall portion.
As mentioned in the above, the device
-9413 ·· Ν Τ '·; Τ ¡NSTTTt.n'C · ”'' / - -Τ.
of constriction and the stimulation device & L cooperate to actively move the ovule in the oviduct of the _______ organ of the patient. This can be obtained using the constriction / stimulation unit shown in the figure
2.
Thus, according to a first option of cooperation, the clamping elements of the constricting device constrict the wall without completely closing the oviduct whereby the flow in the oviduct is restricted and the control device 4 controls the electrical elements 7 to progressively stimulate the constricted wall portion in the current direction downstream or upstream of the oviduct to cause progressive contraction of the wall portion 8 to move the ovule into the oviduct.
According to a second cooperating option, the constriction device constrains the wall portion so that the flow in the oviduct is restricted and the control device 4 controls some electrical elements 7 at one end of the clamping elements 5 and 6 elongated to stimulate the constrained wall portion 8 to close the oviduct at either an upstream end or a downstream end of the wall portion 8. With the oviduct closed in this way, the control device 4 controls the constriction device to increase the constriction of the portion
-95 wall so the ovule in the
<img file="MX353172B_D0078.tif" />
INSTITUTE I ovi downstream or upstream of wall portion 8.
In another embodiment of the invention to carry out the second cooperation option, the constriction device constricts the wall portion so that flow in the oviduct is restricted and the control device 4 controls the stimulation device to stimulate the constricted wall portion while the constriction device varies the constriction of the different areas of the wall portion such that the wall portion is progressively constricted in the downstream or upstream direction of the oviduct. FIG. 16A to FIG. 16F show different stages of operation of said alternative embodiment, which comprises a constriction device 104 that includes two elongated constriction elements 105 and 106 having convex surfaces 107 and 108 that contact a length of the wall portion 8 on mutual sides thereof and a multiplicity of electrical elements 7 (such as electrodes) that are placed on convex surfaces 107 and 108. Control device 4 controls electrical elements 7 during operation of constricting device 104 and controls elongated constricting elements 105 and 106
-96to move in relation to the portion 8 d ^ 'paíéu-.t.ubuiar ..- de · - ·' '<sup>1</sup> «
so that elements 105 and 106 of const ricgiop .. ^ progressively constrain the wall portion 8 and, as shown in Figure 16A to Figure 16D.
Thus, in an initial position of the constriction elements 105 and 106, shown in FIG. 16A, the wall portion is not constricted by the constriction elements 105 and 106 and the electric elements 7 are not energized. Starting from this initial position, the control device 4 controls the constriction elements 105 and 106 to oscillate towards the left ends of the constriction elements 105 and 106, towards the wall portion (indicated by arrows) to constrict portion 8 tubular wall, see Figure 16B while energizing the electrical elements 7 so that the electrical elements 7 contacting the wall portion 8 contract at the end. Figure 16C shows how the oviduct of the tubular wall portion 8 is completely closed by the thickened wall portion 8. Then, as shown in Figure 16C, the control device 4 controls the elements 105 and
106 to move so that their right ends move toward each other (indicated by arrows), while the convex surfaces 107 and 108 of the constraining elements 105 and 106 rotate one about
<img file="MX353172B_D0079.tif" />
the other with the wall portion 8 contrallé im'en't-fe '- themselves, see figure 16D. As a rpsn 1 I, f, 1 body material in the organ oviduct is driven to the right (indicated by a white arrow). When the constriction elements 105 and 106 have been wound over each other to the position shown in Fig. 16C, the control device 4 controls the right ends of the constriction elements 105 and 106 to move away from each other ( indicated by arrows in Figures 16E) to the initial position shown in Figure 16A. The steps of operation described in accordance with Figure 16A to Figure 16E can be cyclically repeated numerous times until the desired amount of body material has been moved through the organ oviduct, in a peristaltic manner.
Alternatively, only one of the constricting elements 105 and 106 can be provided with a convex surface while the other constricting element has a flat surface that contacts the wall portion. It is also possible to use a single constriction element with a convex surface that presses the tubular portion 8 of the organ against a patient bone.
Figure 16 schematically shows a general embodiment of the system of the invention in which the
-98IΜ ΡI
MEXICAN INSTITUTE
PE THE iROfllOAD <'* • <5 #' «^ energy is transferred to components that consflffleff '-' in CT ^ V of the system implanted in the patient. The eietee »a—- € liO '.......- The .....
Figure 16 comprises an implanted constriction / stimulation unit 110 which is operable to gently constrict a portion of the tubular tissue wall of a patient's organ and to stimulate different areas of the constricted portion to cause contraction of the wall portion. The constriction device of the constriction / stimulation unit 110 is capable of performing a reversible function, i.e., constricting and releasing the wall portion such that the constriction / stimulation unit 110 functions as an artificial sphincter.
A power source 111 is adapted to supply power to the consuming components of the power constriction / stimulation unit 110 via a power supply line 112. A wireless remote control or a patient operable subcutaneously implanted switch can be supplied to turn the power supply on or off from the power source. The power source can be a permanent or rechargeable implantable battery or can be included in an external power transmission device which can be operated directly by the patient or can be controlled by a remote control operable by the patient
-99to transmit wireless energy to comp © ne «tl ·.
IMPI
INSTITUTE
<img file="MX353172B_D0080.tif" />
consume energy from the constriction unit / gst
Alternatively, the power source may comprise a combination of an implantable, external rechargeable battery and an external transmitted implantable battery in a power transmission device an energy transformation device for energy to transform an electrical device into an implantable rechargeable.
Figure 17 shows a general embodiment of Figure 16 implanted in a patient and the patient's body. Of all the parts placed on the patient are implanted and the left of the skin 109 others this wireless energy transmission of energy the charging mode that has of the special battery of the some parts located out of the way in figure 17 the right of the skin 109 of the
All the parts placed on are located outside the patient's body. An implanted power device 111A of the system supplying power to the transformation components of this constriction / stimulation unit 110 medium of the power supply line 112 transmission device 111 a wireless signal which is adapted for the consumption of the power supply energy energy.
external by
One of the received by a receiver system includes a wireless remote control that transmits
-100 signal incorporated in the implanted energy transformation.
The
<img file="MX353172B_D0081.tif" />
QSltlVO iNSTirt'fc dispositiva ', 1A
<img file="MX353172B_D0082.tif" />
Transformed power transformer transforms energy from the signal into electrical energy, which is supplied via power supply line 112 to constriction / stimulation unit 110.
The system of Figure 17 may also include an implanted rechargeable battery to energize energy in the implanted components that consume it from the system. In this case, the implanted power transformation device 111A also charges the battery with electrical energy, since the power transformation device transforms signal energy into electrical energy.
An inverter device in the form of an electrical switch 114, such as a microprocessor, is implanted in the patient to reverse the constriction device of the constriction / stimulation unit 110.
The wireless remote control of the device
113 External power transmission transmits a wireless signal that carries power and the device
111A implanted power transformation transforms wireless energy into a current to operate the switch
114. When the current polarity is switched by the switch
114 invert the function performed by the device
111A energy transformation, the
-101-
<img file="MX353172B_D0083.tif" />
<img file="MX353172B_D0084.tif" />
constriction / stimulation constriction device.
Fig. 18 shows an embodiment of the invention including an energy transforming device 111A, the constriction / stimulation unit 110 and an operating device implanted in the form of a motor 115 to operate the constriction device of the constriction unit 110 / stimulation. The motor 115 is powered by power from the power transformation device 111A, to the extent that the remote control from the external power transmission device 113 transmits a wireless signal to the receiver of the power transformation device 111A.
FIG. 19 shows an embodiment of the invention including an energy transformation device 111A, the constriction / stimulation unit 110 and a
<td>mount 116</td><td>implanted</td><td>It includes</td><td>a</td><td>Unit</td><td> 117</td><td>of</td>
<td>motor / pump and</td><td>a deposit</td><td colspan="2">118 fluid.</td><td>In this</td><td>case,</td><td>the</td>
<td>device</td><td colspan="2">constriction</td><td>the</td><td>Unit</td><td> 110</td><td>of</td>
constriction / stimulation is hydraulically operated, i.e. hydraulic fluid is pumped by motor / pump unit 117 from reservoir 118 to constriction / stimulation unit 110 to constrict the wall portion and hydraulic fluid is pumped by the unit 117 motor / pump return from unit 110
-102 constriction / deposit stimulation
IMPI
MEXICAN INSTITUTE OF PROPERTY -1 r, INDUSTRIAL »» .-, · 2
118 to liberate
<img file="MX353172B_D0085.tif" />
wall portion. The implanted energy tr'STTSTOTITraC'lÓll Utí 'device 111A transforms wireless energy into a current, to energize the motor / pump unit 117.
FIG. 20 shows an embodiment of the invention comprising the external power transmission device 113 that controls the control unit 122 to reverse the motor 115 when needed, the constriction / stimulation unit 110, whose constriction device is operated hydraulically and the device
111A for energy transformation implemented and which also includes a tank
119 of implanted hydraulic fluid, an implanted motor / pump unit 120, and an inverter device implanted in the form of a device
121 Hydraulic valve shift a separate external wireless remote controller
111B.
The motor of the motor / pump unit 120 is an electric motor.
In response to a control signal from the device's wireless remote control
113 external power transmission, the device
111A implanted power transformation powers the unit
120 of motor / pump with energy from the energy carried by the control signal, so the unit 120 of
119 and the constriction device of the motor / pump unit 110 distributes hydraulic fluid between the reservoir
-103I i constriction / stimulation. The remote control ^ rj ^ jj / g.gntrgí-áy ^ -<sup>7</sup> displacement device 121 stops the direction in which hydraulic fluid flow between one direction the fluid is pumped by the motor / pump unit 120 from the reservoir
119 to the constriction device of the constriction / stimulation unit 110 to constrict a portion of the wall, and another opposite direction in which the fluid is pumped by the motor / pump unit 120 back from the constriction device of the unit 110 of constriction / stimulation to reservoir 119 to release the wall portion.
invention
The figure shows one embodiment of which an energy transforming device 111A includes the constriction / stimulation unit 110. A control unit 122, an accumulator 123 and a capacitor
124 they are also implanted in the patient. A separate remote control 111B wireless external control unit 122. Control unit 122 controls power transformation device 111A to store electrical energy in accumulator 123, which supplies power to stimulation / constriction unit 110. In response to a control signal from the wireless remote control 111B, the control unit 122 releases electrical energy from the accumulator 123 and transfers the released energy via lines of
-104IMPI
INSTITUTO MEXICANO energy or directly transfers energy, device 111A for transformer capacitor 124, which stabilizes the de-RTisraía via the electric current, for the operation of the unit
110 of constriction / stimulation.
According to an alternative, capacitor 124 in the embodiment of Figure 21 can be omitted. According to another alternative, accumulator 123 in this mode can be omitted.
Fig. 22 shows an embodiment of the invention including an energy transformation device 111A, the constriction / stimulation unit 110. A battery 125 for supplying power for the operation of the constriction / stimulation unit 110 and an electrical switch 126 for switching the operation of the constriction / stimulation unit 110 are also implanted in the patient. Switch 126 is operated by power supplied by power transformer device 111A to switch from an off mode, in which battery 125 is not in use, to an on mode, in which battery 125 supplies electrical power for the operation of the constriction / stimulation unit 110.
Figure 23 shows an embodiment of the invention identical to that of Figure 43, except that a "
-105 control unit 122 is also implanted
<img file="MX353172B_D0086.tif" />
<img file="MX353172B_D0087.tif" />
INSTI'v ~>
in euite
<img file="MX353172B_D0088.tif" />
A separate external wireless remote control 111B controls the control unit 122. In this case, the switch 126 is operated by the power supplied by the power transforming device 111Ά to the switch from an inactive mode, in which the wireless remote control 111B is prevented from controlling the control unit 122 and the battery 125 is not It's in use, to a standby mode in which the remote control 111B is allowed to control the control unit 122 to release electrical energy from the battery 125 for the operation of the constriction / stimulation unit 110.
Figure 24 shows an embodiment of the invention identical to that of Figure 44, except that accumulator 123 is replaced by battery 125 and implanted components are interconnected differently. In this case, the accumulator 123 stores energy from the energy transformation device 111A. In response to a control signal from the wireless remote control 111B, the implanted control unit 122 controls switch 126 to switch from an off mode, in which accumulator 123 is not in use to an on mode in which accumulator 123 supplies power for the operation of the constriction / stimulation unit 110.
Figure 25 shows a modality of the «
-106IMPI
MEXICAN INSTITUTE
<img file="MX353172B_D0089.tif" />
. , _. THE rKOPIEOAD., -. 1: 1 / ¾ invention identical to that of figure 45 except ^ RSML qñ ^ CSlJp * battery 125 is also implanted in ei — paci & n-Le — and — implanted components interconnect differently. In response to a control signal from the wireless remote control 111B, the implanted control unit 122 controls the accumulator 123 which may be a capacitor to supply power to operate the switch 126 to switch in an off mode in which the battery 125 does not it is in use in an on mode in which the battery 125 supplies electrical power for the operation of the constriction / stimulation unit 110 '.
Alternatively, switch 126 may be operated by power supplied by accumulator 123 to switch in an off mode in which wireless remote control 111B is prevented from controlling battery 125 to supply electrical power and battery 125 is not in use , to a standby mode in which the wireless remote control 111B is allowed to control the battery 125 to supply electrical power for the operation of the constriction / stimulation unit 110.
Fig. 26 shows an embodiment of the invention identical to that of Fig. 43, except that a motor 115, a mechanical reversing device in the form of a gear 127 and a control unit 122 for controlling
-107-
<img file="MX353172B_D0090.tif" />
gear 127 is implanted in the patient! í ¥ ^ J //. I $ i .γρόηΐ / ρρί / ·
I1NÜÜ5! k.AL * ·· .__
111B separate external wireless remote controls the unit
122 control switch to control gear 127 to reverse the function performed by the (mechanically operated) constriction device of the unit
110 of constriction / stimulation.
Figure 27 shows an embodiment of the invention identical to that of Figure 46, except that the implanted components are interconnected differently.
Thus, in this case, the battery
125 energizes the control unit 122 when the accumulator
123, suitably a capacitor, activates switch 126 to switch to an on mode. When the switch 126 is in the on mode, the control unit 122 is allowed to control the battery 125 to supply, or not to supply, power for the operation of the constriction / stimulation unit 110.
FIG. 28 shows an embodiment of the invention identical to that of FIG. 39, except that a gear 127 connecting motor 115 to constriction / stimulation unit 110 and a control unit 122 that controls power transformation device 111A Powered by motor 115 they are also implanted into the spacer that controls patient control unit 122. There is an external 111B wireless remote control
<img file="MX353172B_D0091.tif" />
<img file="MX353172B_D0092.tif" />
-108 reverse motor 115 when needed.
Optionally, the accumulator 123 shown in FIG. 21 can be provided in the embodiment of FIG. 49, wherein the implanted control unit 122 controls the power transformation device 111A to store the transformed energy in the accumulator 123. In response to a control signal from the wireless remote control 111B, the control unit 122 controls the accumulator 123 to supply power for the operation of the constriction / stimulation unit 110.
Those skilled in the art will realize that various prior modalities in accordance with Figure 17 through Figure 28 can be combined in many different ways. For example, the power operated switch 114 can be incorporated in any of the modes of Figure 18 and Figure 21 to Figure 28, the hydraulic displacement device 121 can be incorporated in the mode of Figure 21 and the gear 127 may be incorporated in the embodiment of FIG. 39. Switch 114 may be a type that includes electronic components, for example a microprocessor or
<td>an FGPA</td><td>(field programmable gate arrangement)</td>
<td>designed</td><td>for switching. Alternatively, no</td>
<td>However,</td><td>the power operated switch 114 can be</td>
-109 replaced by a [nstír :: ru - · /; -. <- - button <sub>F</sub>-. -and/
L'E La;
push<sup>F</sup>'itibia nt aófé—' subcutaneously which is switched manually between the patient on and off.
Alternatively, a permanent or rechargeable battery may be replaced by power transformer devices 111A in the modalities shown from Figure 38 to Figure 49.
Fig. 29 shows basic parts of a remote control of the system of the invention for controlling the constriction / stimulation unit 110. In this case, the stimulation device of the constriction / stimulation unit stimulates the wall portion with electrical pulses. The remote control is based on the wireless transmission of electromagnetic wave signals, often of high frequencies, in the order of 100 kHz - 1 gHz, through the patient's skin 132. In FIG. 29, all parts positioned to the left of skin 132 are located outside of the patient's body and all parts positioned to the right of skin 132 are implanted.
An external signal transmitting device 133 is to be positioned close to a signal receiving device 134 implanted close to the skin 132. As an alternative, the signal receiving device 134 may be placed, for example, within the patient's abdomen. The
-110IMPI
INSTITOT- F '<·.
device 134 signal receiver comprises '' üiidjJbófei approximately 1-100 «
mm, pref er ~ ih! I have 25 mm diameter wound with a very thin wire and tuned with a capacitor at a specific high frequency. A small coil is selected if to implant under the patient implant in transmission that of approximately device 134 an abdominal coil of the patient is selected. The signal comprises the same size signal receiver a large if going to coil device 133 which has to coil but wound with thick wire that can handle larger currents, if necessary. The coil of the signal transmission device 103 is tuned to the same as the coil of the device 134
The specific high-frequency device 133 for receiving the signal.
Signal transmission is adapted to output digital information by means of the power amplifier and signal receiving device 134 to an implanted control unit 135. To prevent accidental random high frequency fields from activating control instructions, digital signal codes are used. A conventional keyboard placed in the signal transmission device 133 is used in order for the signal transmission device 133 to output digital signals for the control of the constriction / stimulation unit. Device 133 of
I
-111INSTITUTO vi;>; · \ eg the, '+ γ :::. · J \ .ó a signal transmission geft'é'íañtio initiates high-frequency signal.
After tm<sup>1</sup>· Ti when the signal has energized the implanted parts of the control system, instructions are sent to operate the constriction device of the constriction / stimulation unit 110 in predefined stages. Instructions are sent as digital packets in the form
<td colspan="3">illustrated below.</td>
<td>Start pattern,</td><td> 8</td><td>bits</td>
<td>Instruction</td><td> 8</td><td>bits</td>
<td>Bill</td><td> 8</td><td>bits</td>
<td>Sum Verification</td><td> 8</td><td>bits</td>
<td>The instructions are</td><td></td><td>continuously sent</td>
for a rather long period of time (for example, about 30 seconds or more). When a new constraint or release stage is desired, the account byte is incremented by one to allow the unit
135 control device decode and understand that another stage is requested by the device
133 signal transmission.
If any part of the digital package is wrong, its content is simply ignored.
Via a line 136, an implanted energizing unit 137 draws energy from the high frequency electromagnetic wave signals received by the signal receiving device 134. Unit 137
-112-
<img file="MX353172B_D0093.tif" />
energizer stores energy in a
INSTITUI ''? '
D'í Ha.
Source d'S '' 'ert erg íh such as a large capacitor, energizing control and energizing the constriction / stimulation unit 110 via line 138.
Control unit 135 comprises a demodulator and a microprocessor. The demodulator demodulates digital signals sent from the device
133 signal transmission. The microprocessor receives the digital packet, decodes it, and sends a control signal via signal line 139 to control the constriction device of the constriction / stimulation unit 110 to constrain or release the wall portion of the patient's organ depending on the code. of instruction received.
Figure 30 shows a circuitry in an embodiment of the invention in which wireless energy is transformed into a current. The external components of the circuitry include a microprocessor 140, a signal generator 141 and a power amplifier 142 connected thereto. Microprocessor 140 is adapted to turn on / off signal generator 141 and to modulate signals generated by signal generator 141 with digital instructions. The power amplifier 142 amplifies the signals and sends them to an external signal transmission antenna coil 143. Coil 143
-113IMPI
M.-Xl INSTITUTE, -. DE M antenna connects in parallel with a capacitor<sup>UJ1,</sup> form a resonant circuit
<img file="MX353172B_D0094.tif" />
tuned to that generated by generator 141
The implanted components of the circuitry include a signal receiving antenna coil 145 and a capacitor 146 that together form a resonant circuit that is tuned to the same frequency as coil 143 of the transmitting antenna. The signal receiving antenna coil 145 induces a current from the received high frequency electromagnetic waves and a rectifying diode 147 rectifies the induced current, which charges a storage capacitor 148. Capacitor
148 The storage energizes a motor 149 to drive the constriction device of the constriction / stimulation unit 110. A coil 150 connected between the capacitor 148 antenna coil 145 and the receiving antenna diode 145 In this way, the capacitor coil 148 and transmit amplitude modulation.
and diode 147 prevents 147 from loading the signal circuit at higher frequencies.
150 makes it possible to upload digital information using
A capacitor 151 and a resistor 152 connected in parallel and a diode 153 form a detector used to detect amplitude modulated digital information.
A filter circuit is made up of a resistor
154
-114 connected in series
1MF I
INSTITUTO Mcx; r, · - *; ·} <sup>1</sup> · Λ
FROM THE PRC?!?<sup>-</sup> '/>.n' O * - ·. Λ '3 * with a 155 resistor 3PV<sup>ST</sup>^ ft with a 156 capacitor connected in series with<sup>1</sup> 'el — yegríator
<td colspan="2">via grounding and</td><td>a capacitor</td><td> 157,</td><td>a terminal</td><td>of the</td>
<td>which one</td><td colspan="2">connects between resistors</td><td> 154</td><td colspan="2">and 155 and the other</td>
<td>terminal</td><td>which is</td><td>connects between</td><td>the</td><td>diode 153 and</td><td>the</td>
<td>circuit</td><td>formed by the</td><td>capacitor 151</td><td>and the</td><td>resistor 152.</td><td>. The</td>
Filter circuitry is used to filter out low and high unwanted frequencies. The detected and filtered signals are fed to a microprocessor
158 implanted that decodes digital information and controls motor 149 by means of an H-bridge 159 comprising transistors 160, 161, 162, and 163. Motor 149 can be driven in opposite directions by the bridge
159 in H.
Microprocessor 158 also monitors the amount of energy stored in storage capacitor 148. Before sending signals to activate motor 149, microprocessor 158 checks whether the energy stored in storage capacitor 148 is sufficient. If the stored energy is not sufficient to perform the requested operation, the microprocessor 158 waits for the received signal to charge the storage capacitor 148 before activating the motor 149.
Alternatively, the energy stored in the storage capacitor 148 can only be
-115 used to power a switch
IMP i O'-j
INSTITUTO MEXICAN A t ' <sup>1</sup> .1, FROM PROPERTY, C * ·· - / and the eo®-ttí gu power motor 149 you can get Hp nt-ra fnont-o Hr____ implanted power of relatively high capacity, for example a battery. In this case, the switch is adapted to connect the battery to motor 14 9 in an on mode when the switch is powered by storage capacitor 148 and to keep the battery disconnected from motor 149 in a standby mode when the switch is not energized.
Although the invention has been described in relation to what is currently considered to be the most practical and preferred embodiment, it should be understood that the invention is not limited to the disclosed embodiment but rather is intended to encompass various modifications and 15 equivalent distributions included within the spirit and scope of the appended claims.
t
-116-
Contents60
116 sheets
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731 members in 21 offices
Members731
| Document | Office | Kind | |
|---|---|---|---|
| AU2008309868A1 | Australia | A1 | |
| AU2008309868A1 | Australia | A1 | |
| AU2008309869A1 | Australia | A1 | |
| AU2008309870A1 | Australia | A1 | |
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1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Grant or registrationFG | FG |
Numbers
- Publication
- 353172
- Application
- 3938
Titles2
- Spanish
- SISTEMA Y METODO PARA CONTROL DE EMBRION.
- English
- SYSTEM AND METHOD FOR EMBRYO CONTROL.
Classification
- CPC, 7
- A61B17/425
- A61B17/12
- A61B2017/00411
- A61F6/22
- A61N1/36007
- A61F6/20
- A61F6/202
- IPC, 4
- A61B17 12
- A61B17 425
- A61F6 22
- A61N1 36
