Pyrrolidinones as herbicides

Description: (The description is published in the version drafted by the applicant)

FIELD OF THE INVENTION

The present invention relates to certain pyrrolidinones, their N-oxides and salts, and their compositions and methods of use for the control of undesirable vegetation.

STATE OF THE ART IN THE FIELD OF THE INVENTION

Controlling unwanted vegetation is extremely important for achieving high crop efficiency. Selective control of weed growth is highly desirable, especially in useful crops such as rice, soybeans, sugar beets, corn, potatoes, wheat, barley, tomatoes, and plantations (monocultures), among others. Uncontrolled weed growth in such useful crops can result in significant reductions in productivity, thereby increasing costs for consumers. Controlling unwanted vegetation is also important in uncultivated areas. Many products are commercially available that serve this purpose.

WO2004/037787 discloses various 1-phenylpyrrolidin-2-one-3-carboxamides which are claimed to be herbicidally active.

US 4,874,422 discloses 1-phenyl-3-carboxyamidopyrrolidones which are believed to be useful as herbicidal agents.

WO00/09481 discloses various cyclic amide compounds having two substituents at the a-position of the carbonyl group which are claimed to be herbicidally effective.

But there is a continuing need for new compounds that are more effective, less expensive, less toxic, safer for the environment, or have different sites of action.

The claimed invention overcomes the disadvantages of the compounds described in the above-mentioned documents by obtaining compounds that are more effective, less expensive, less toxic, safer for the environment and have different sites of action.

SUMMARY OF THE INVENTION

The present invention relates to compounds having Formula 1 (including all stereoisomers), including their N-oxides and salts, agricultural compositions containing them and their use as herbicides:

<img file="MD4889B1_D0001.tif" />

in which

Q¹is a phenyl ring or naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁷; or a 5 to 6 membered fully unsaturated heterocyclic ring or an 8 to 10 membered bicyclic heteroaromatic system, each ring or ring system containing members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O atoms, up to 2 S atoms and up to 4 N atoms, where up to 3 of the ring member carbon atoms are independently selected from C(=O) and C(=S), and the ring member sulfur atoms are independently selected from S(=O)u(=NR⁸)v, each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁷in the case of ring member carbon atoms and selected from R⁹in the case of ring member nitrogen atoms;

Q²is a phenyl ring or naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹⁰; or a 5 to 6 membered fully unsaturated heterocyclic ring or an 8 to 10 membered bicyclic heteroaromatic system, each ring or ring system containing members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O atoms, up to 2 S atoms and up to 4 N atoms, where up to 3 of the ring member carbon atoms are independently selected from C(=O) and C(=S), and the ring member sulfur atoms are independently selected from S(=O)u(=NR⁸)v, each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹⁰in the case of ring member carbon atoms and selected from R¹¹in the case of ring member nitrogen atoms;

Y¹is O or NO¹²;

MD 4889 B1 2024.03.31

Y²is O or S;

r¹is H, hydroxy, amino, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 3 -C 6 alkynyl, C 4 -C 8 cycloalkylalkyl, C 2 -C 8 alkoxyalkyl, C 2 -C 8 haloalkyl, C 2 -C 8 alkylthioalkyl, C 2 -C 8 alkylsulfinylalkyl, C2-C8 alkylsulfonylalkyl, C2-C8 alkylcarbonyl, C2-C8 haloalkylcarbonyl, C4-C10 cycloalkylcarbonyl, C2-C8 alkoxycarbonyl, C2-C8 haloalkoxycarbonyl, C4-C10 cycloalkoxycarbonyl, C2-C8 alkylaminocarbonyl, C3-C10 dialkylaminocarbonyl, C4-C10 cycloalkylaminocarbonyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C3-C8 cycloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C3-C8 cycloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C3-C8 cycloalkylsulfonyl, C1-C6 alkylaminosulfonyl, C2-C8 dialkylaminosulfonyl or C3-C10 trialkylsilyl;

r² și R³are each independently H, halogen or C1-C4 alkyl;

r⁴ și R⁵are each independently H, halogen or C1-C4 alkyl;

r⁶is H, hydroxy, amino, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C3-C6 alkynyl, C2-C8 alkoxyalkyl, C2-C8 haloalkoxyalkyl, C2-C8 alkylthioalkyl, C2-C8 alkylsulfinylalkyl, C2-C8 Alkylsulfonylalkyl, C2-C8 Alkylcarbonyl, C2-C8 Haloalkylcarbonyl, C4-C10 Cycloalkylcarbonyl, C2-C8 Alkoxycarbonyl, C2-C8 Haloalkoxycarbonyl, C4-C10 Cycloalkoxycarbonyl, C2-C8 Alkylaminocarbonyl, C3-C10 Dialkylaminocarbonyl, C4-C10 Cycloalkylaminocarbonyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C3-C8 cycloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C3-C8 cycloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C3-C8 cycloalkylsulfonyl, C1-C6 alkylaminosulfonyl, C2-C8 dialkylaminosulfonyl or C3-C10 trialkylsilyl;

each R7 and R¹⁰is independently halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl, C1-C4 nitroalkyl, C2-C4 Nitroalkenyl, C2-C4 Alkoxyalkyl, C2-C4 Haloalkoxyalkyl, C3-C4 Cycloalkyl, C3-C4 Halocycloalkyl, Cyclopropylmethyl, Methylcyclopropyl, C1-C4 Alkoxy, C1-C4 Haloalkoxy, C2-C4 Alkenyloxy, C2-C4 Haloalkenyloxy, C3-C4 Alkynyloxy, C3-C4 haloalkynyloxy, C3-C4 cycloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylsulfonyl, hydroxy, formyl, C2-C4 alkylcarbonyl, C2-C4 alkylcarbonyloxy, C1-C4 alkylsulfonyloxy, C1-C4 haloalkylsulfonyloxy, amino, C1-C4 alkylamino, C2-C4 dialkylamino, formylamino, C2-C4 alkylcarbonylamino, -SF5, -SCN, C3-C4 trialkylsilyl, trimethylsilylmethyl or trimethylsilylmethoxy; and each R⁸is independently H, cyano, C 2 -C 3 alkylcarbonyl or C 2 -C 3 haloalkylcarbonyl;

Each R⁹ și R¹¹is independently cyano, C 1 -C 3 alkyl, C 2 -C 3 alkenyl, C 2 -C 3 alkynyl, C 3 -C 6 cycloalkyl, C 2 -C 3 alkoxyalkyl, C 1 -C 3 alkoxy, C 2 -C 3 alkylcarbonyl, C 2 -C 3 alkoxycarbonyl, C 2 - C3 alkylaminoalkyl or C3-C4 dialkylaminoalkyl;

Each R¹²is independently H, cyano, C1-C4 alkyl, C1-C4 haloalkyl, -(С=О)СН3 or -(C=O)CF3;

And each u and v are independently 0, 1, or 2 in each instance of S(=O)u(=NR⁸)v, provided that the sum of u and v is 0, 1 or 2;

provided that (a) the compound of Formula 1 is different from N-1H-benzotriazol-1-yl-2-oxo-4-phenyl-3-pyrrolidinecarboxamide;

(b) when Q¹contains a 3-furanyl or 3-pyridinyl ring directly linked to the rest of Formula 1, said ring is substituted with at least one substituent selected from R 7;

(c) when Q¹is an unsubstituted phenyl ring, and Q²contains a phenyl ring directly linked to the remainder of formula 1, the Q ring²mentioned is replaced by R¹⁰other than phenoxy or F optionally substituted in a 2-position, cyano or -CF3 in the 4-position, and R⁵is H or halogen;

(d) when Q¹is unsubstituted phenyl, and Q²contains a pyridinyl ring directly linked to the remainder of Formula 1, said pyridinyl ring is substituted with at least one substituent selected from R¹⁰;

(e) when Q¹is a phenyl ring substituted with 4-phenyl or 4-phenoxy, the Q ring¹said is further substituted with an R substituent⁷;

(f) when Q¹contains a phenyl ring directly linked to the residue of Formula 1, and said ring is substituted with R7 in both ortho positions (relative to the bond to the residue of Formula 1), said ring is also independently substituted with R7 in at least one more additional position;

(g) when Q¹is unsubstituted 1-naphthalenyl, Q²is different from 2,3-difluorophenyl or 2-CF3phenyl;

(h)Q²is different from optionally substituted 1H-pyrazol-5-yl; and

MD 4889 B1 2024.03.31 (i) when Q²confines a legal 1H-pyrazol-3-yl ring directly from the remainder of Formula 1, said ring being substituted in position 1 with R¹¹.

More specifically, the present invention relates to a compound of Formula 1 (including all stereoisomers), an N-oxide or a salt thereof. The present invention also relates to a herbicidal composition consisting of a compound of the invention (namely in a herbicidally effective amount) and at least one ingredient selected from the group consisting of surfactants, solid solvents and solvents liquids, the composition additionally consisting of at least one additional active ingredient selected from the group consisting of other herbicides and phytoprotective adjuvants against herbicides. The present invention also relates to a method for controlling the growth of unwanted vegetation comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of the invention (e.g. in the form of a composition described in this document). DETAILS OF THE INVENTION

As used herein, the terms "consist of", "consisting of", "includes", "including", "has", "having", "contains", "containing", "characterized by" or any other variations thereof are intended to mean a non-exclusive inclusion, subject to any limitation that is expressly indicated. For example, a composition, mixture, process or method comprising a list of elements is not necessarily limited to only those elements, but may include other elements not expressly listed or inherent in such compositions, mixtures, processes or methods.

The linking phrase "comprised of" excludes any unspecified element, step or ingredient. If found in the claim, this phrase limits the inclusion in the claim of materials other than those enumerated, except for impurities ordinarily associated therewith. When the phrase "composed of" appears in a sentence of a claim, as opposed to its presence immediately after the preamble, it limits only the element set forth in that sentence; no other elements are excluded from the claim considered as a whole.

The linking phrase "consisting principally of" is used to define a composition or method that includes materials, steps, features, ingredients or elements additional to those literally disclosed, provided that such materials, steps, features, ingredients or additional elements do not materially affect the basic feature(s) and innovative feature(s) of the claimed invention(s). The term "consisting principally of" falls somewhere between "consisting of" and "consisting of".

Where applicants have defined an invention or part thereof with an open term such as "consisting of", it is to be understood that (unless otherwise stated) the description is also to be construed as referring to the invention using the terms "consisting principally of" and "consisting of".

In addition, unless otherwise stated, "or" is inclusive and not exclusive. For example, a condition A or B is satisfied by either of the following statements: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and A and B are both true (or present).

Likewise, the indefinite articles "an" and "o" preceding an element or ingredient of the invention are not restrictive as to the number of occurrences (occurrences) of the element or ingredient. Therefore, "a" or "a" must be read to include an element or ingredient or at least one element or ingredient, and the singular form of the element or ingredient also includes the plural, unless it clearly refers in the singular.

As used herein, the term "seedling", used either alone or in association with other words, means a young plant that develops from the embryo of a seed.

As used herein, the term "broadleaf", used either alone or in association with other words such as "broadleaf weeds", means dicotyledons, a term used to describe a group of angiosperms characterized by the fact that the embryo has two cotyledons.

As used herein, the term "alkylating agent" refers to a chemical compound in which a carbon-containing radical is linked through a carbon atom to a volatile group such as halide or sulfonate, which is displaceable by binding of a nucleophilic group at said carbon atom. Unless otherwise specified, the term "alkylation" does not limit the carbon-containing radical to alkyl; carbon-containing radicals in alkylating agents include the variety of carbon-bonded substituent radicals specified for R¹.

In the above statements, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl", includes a straight or branched chain alkyl such as methyl, ethyl, n -propyl, i -propyl or the different butyl, pentyl or hexyl isomers. "Alkenyl" includes chained alkenes

MD 4889 B1 2024.03.31 linear or branched, such as ethenyl, 1-propenyl, 2-propenyl and the various isomers of butenyl, pentenyl and hexenyl. "Alkenyl" also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. "Alkynyl" includes straight or branched chain alkynes such as ethynyl, 1-propynyl, 2-propynyl and the various isomers of butynyl, pentynyl and hexynyl. "Alkynyl" may also include moieties consisting of multiple triple bonds, such as 2,5-hexadiinyl.

"Alkoxy" includes, for example, methoxy, ethoxy, n-propyloxy, isopropyloxy and the various isomers of butoxy, pentoxy and hexyloxy. "Alkoxyalkyl" denotes the substitution of alkoxy for alkyl. Examples of "Alkoxyalkyl" include CH3OCH2, CH3OCH2CH2, CH3CH2OCH2, CH3CH2CH2CH2OCH2 and CH3CH2OCH2CH2. "Alkoxyalkoxyalkyl" denotes at least the alkoxy substitution on the alkoxy moiety of the alkoxyalkyl moiety. Examples of "AlkoxyAlkoxyalkyl" include CH3OCH2OCH2-, CH3CH2O(CH3)CHOCH2-, and (СНзО)2СНОСН2-. "Alkoxyalkyl" denotes the substitution of alkoxy for alkoxy. "Alkenyloxy" includes linear or branched alkenyloxy moieties. Examples of "alkenyloxy" include H2C=CHCH2O, (CH3)2C=CHCH2O, (СНз)СН=СНСН2О, (СНз)СН=С(СНз)СН2О and CH2=CHCH2CH2O. "Alkynyloxy" includes straight or branched chain alkynyloxy moieties. Examples of "alkynyloxy" include HC^CCH₂O, СНзС^ССН₂О and СНзС.АССН₂СН₂О. "Alkylthio" includes straight or branched chain alkylthio moieties such as methylthio, ethylthio and the various isomers of propylthio, butylthio, pentylthio and hexylthio. "Alkylsulfinyl" includes both enantiomers of an alkylsulfinyl group. Examples of "alkylsulfinyl" include CH3S(O)-, СНзСН28(О)-, CH3CH2CH2S(O)-, (CH3)2CHS(O)-, and the various butylsulfinyl, pentylsulfinyl, and hexylsulfinyl isomers. Examples of "alkylsulfonyl" include CH3S(O)2-, CH3CH2S(O)2-, CH3CH2CH2S(O)2-, (СНз)2СНБ(О)2- and the various butylsulfonyl, pentylsulfonyl, and hexylsulfonyl isomers. "Alkylthioalkyl" denotes the substitution of alkylthio for alkyl. Examples of "alkylthioalkyl" include CH3SCH2, CH3SCH2CH2, CH3CH2SCH2, CH3CH2CH2CH2SCH2 and CH3CH2SCH2CH2. "Alkylsulfinylalkyl" denotes the substitution of alkylsulfinyl for alkyl. Examples of "alkylsulfinylalkyl" include CH3S(=O)CH2, CH3S(=O)CH2CH2, CH3CH2S(=O)CH2 and CH3CH2S(=O)CH2CH2. "Alkylsulfonylalkyl" denotes the substitution of alkylsulfonyl for alkyl. Examples of "alkylsulfinylalkyl" include CH3S(=O)2CH2, CH3S(=O)2CH2CH2, CH3CH2S(=O)2CH2 and

CH3CH2S(=O)2CH2CH2. "Alkylamino", "dialkylamino" and similar terms are defined analogously to the examples above. Examples of "alkylaminoalkyl" include CH3NHCH2-, (СНз)2СНМНСН2- and СНзИНСН(СНз)-. Examples of "dialkylaminoalkyl" include (CH_;)₂CH₂-, (CH_;)₂NC(CH_;)H- and (СНз)(СНз)ИСН2-. Examples of "dialkylaminocarbonyl" include (СН3)₂НС(О)-. Examples of "dialkylaminosulfonyl" include (CH 3) 2 NS(O) 2 -. The term "Alkoxycarbonylamino" denotes straight or branched chain alkoxy moieties linked to a C(=O) moiety of the carbonylamino group. Examples of "carbonylamino" include CH 3 OC(=O)NH- and CH 3 CH 2 OC(=O)NH-.

"Cycloalkyl" includes, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term "alkylcycloalkyl" denotes alkyl substitution on a cycloalkyl moiety and includes, for example, ethylcyclopropyl, ipropylcyclobutyl, 3-methylcyclopentyl and 4-methylcyclohexyl. The term "cycloalkylalkyl" denotes substitution with cycloalkyl on an alkyl moiety. Examples of "cycloalkylalkyl" include cyclopropylmethyl, cyclopentylethyl and other cycloalkyl moieties linked to straight or branched chain alkyl groups. The term "cycloalkyl" denotes cycloalkyl legal through one oxygen atom, such as cyclopentyloxy and cyclohexyloxy. "Cycloalkylalkoxy" denotes legal cycloalkylalkyl through an oxygen atom attached to the alkyl chain. Examples of "cycloalkylmethoxy" include cyclopropylmethoxy, cyclopentylethoxy and other cycloalkyl moieties linked to straight or branched chain alkoxy groups. "Cycloalkenyl" includes groups such as cyclopentenyl and cyclohexenyl, as well as groups with more than one double bond, such as 1,3- and 1,4-cyclohexadienyl.

The term "halogen", either alone or in compound words such as "haloalkyl", or when used in descriptions such as "halogen substituted alkyl", includes fluorine, chlorine, bromine or iodine. In addition, when used in compounds such as "haloalkyl" or when used in descriptions such as "halogen substituted alkyl", said alkyl may be partially or completely substituted with halogen atoms, which may be the same or may be different. Examples of "haloalkyl" or "halogen substituted alkyl" include F 3 C, ClCH 2, CF 3 CH 2 and CF 3 CCl 2. The terms "halocycloalkyl", "haloalkoxy", "haloalkylthio", "haloalkenyl", "haloalkynyl", "haloalkenyloxy", "haloalkylcarbonylamino", "haloalkylsulfonylamino", "haloalkylsulfonyloxy", "haloalkoxyalkyl", "haloalkylcarbonyloxy", "haloalkylaminoalkyl" and others the like are defined analogously to the term "haloalkyl". Examples of "haloalkyl" include CF 3 O-, CCl 3 CH 2 O-, HCF 2 CH 2 CH 2 O- and CF 3 CH 2 O-. Examples of "haloalkylthio" include CCl 3 S-, CF 3 S-, CCl 3 CH 2 S- and ClCH 2 CH 2 CH 2 S-. Examples of "haloalkylsulfinyl" include CF3S(O)-, CCbSCO)-, CF3CH2S(O)-, and CF3CF2S(O)-. Examples of "haloalkylsulfonyl" include CF3S(O)2-, CChSlOA-. CF3CH2S(O)2- and CF3CF2S(O)2-. Examples of "haloalkenyl" include (Cl) 2 C=CHCH 2 - and CF 3 CH 2 CH=CHCH 2 -. Examples of "haloalkenyloxy" include (Cl) 2 C=CHCH 2 O- and CF 3 CH 2 CH=CHCH 2 O-. Examples of "haloalkynyl" include HC CCHCl-, (AC C-, CCFC C- and FCH_;C CCI l·-. Examples of "haloalkyl" include CF3OCH2-, ClCH2CH2OCH2CH2-, Cl3CCH2OCH2-, as well as branched alkyl derivatives. Examples of

MD 4889 B1 2024.03.31 "haloalkoxycarbonyl" include CF3OC(O)-, CICH2CH2OCH2CH2-, С1зССН2ОСН2ОС(О)-, as well as branched alkyl derivatives.

The term "alkylcarbonyl" denotes straight or branched chain alkyl moieties linked to a C(=O) moiety. Examples of "alkylcarbonyl" include CH зС(=О)-, CH 3 CH 2 CH 2 C(=O)- and (CH 3) 2 CHC(=O)-. Examples of "Alkoxycarbonyl" include CH3OC(=O)-, СНзСН2ОС(=О)-,

CH3CH2CH2OC(=O)-, (CH3)2CHOC(=O)- and the various isomers of butoxy- or pentoxycarbonyl. "Cycloalkylalkyloxycarbonyl" denotes cycloalkylalkyl moieties linked to an oxygen atom of the alkoxycarbonyl moiety. Examples of "cycloalkylalkoxycarbonyl" include cyclopropyl-CH2OC(=O)-, cyclopropylСН(СНз)ОС(=О)-, and cyclopentyl-CH2OC(=O)-.

The total number of carbon atoms in a substitution group is indicated by the prefix "Ci-Cj", where i and j are numbers from 1 to 12. For example, C1-C4 alkylsulfonyl denotes compounds from methylsulfonyl to butylsulfonyl; C2 alkoxyalkyl denotes CH3OCH2-; C3 alkoxyalkyl denotes, for example, СнзСН(ОСНз)-, CH3OCH2CH2- or CH3CH2OCH2-; and C 4 alkoxyalkyl denotes the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH 3 CH 2 CH 2 OCH 2 - and CH 3 CH 2 OCH 2 CH 2 -.

When a compound is substituted with a substituent having a subscript signifying that the number of substituents may exceed 1, said substituents (when exceeding 1) are independently selected from a group of defined substituents, for example [R⁷⁾n], where n is 1, 2, 3, 4 or 5). In addition, when the subscript refers to a range, eg (R)i-j, the number of substituents may be selected from the integers between i and j, inclusive. When a group contains a substituent which may be hydrogen, for example R¹ sau R², when this substituent is hydrogen, this is considered to be equivalent to that group being unsubstituted. When a variable grouping is said to be optionally bound in a position, for example [R⁽⁷⁾n], where n can be 0, the hydrogen can be found in that position, even if it is not mentioned in the definition of the variable group. When one or more positions of a group are stated to be "unsubstituted" or "unsubstituted," the hydrogen atoms are bound to occupy any vacant valence.

The term "fully saturated" refers to a ring of atoms in which all the bonds between the ring atoms are single. The term "fully unsaturated" refers to a ring of atoms in which the bonds between atoms are single or double bonds according to valence bond theory, and in addition, the bonds between atoms include as many double bonds as possible without them being cumulative (ie C=C=C, N=C=C etc. are excluded). The term "partially unsaturated" refers to a ring containing at least one member linked to an adjacent member of the ring by a double bond and which theoretically could accept a number of non-cumulative double bonds between adjacent members (in its fully unsaturated) greater than the number of double bonds present (in its partially unsaturated form). When a fully unsaturated ring obeys Huckel's rule, it can also be described as aromatic.

Unless otherwise indicated, a "ring" or "cyclic system" component of Formula 1 (eg the substituent Q¹) is carbocyclic or heterocyclic. The term "cyclic system" denotes two or more fused rings. The terms "bicyclic system" and "fused bicyclic system" denote a cyclic system composed of two fused rings, in which each ring may be saturated, partially unsaturated, or fully unsaturated, unless otherwise indicated. The term "fused heterobicyclic system" denotes a fused bicyclic system in which at least one atom is not carbon. A "bridged bicyclic system" is formed by bonding a segment composed of one or more atoms to non-adjacent members of a ring. The term "ring member" refers to an atom or other moiety (eg C(=O), C(=S), S(O) or S(O) 2) that forms the main chain of a ring or system cyclic.

The term "carbocyclic ring", "carbocycle" or "carbocyclic system" denotes a ring or ring system in which the atoms forming the main chain of the ring are exclusively carbon atoms. Unless otherwise stated, a carbocyclic ring may be a saturated, partially unsaturated or fully unsaturated ring. When a fully unsaturated carbocyclic ring obeys Huckel's rule, the ring is also called an "aromatic ring". "Saturated carbocyclic" refers to a ring having a main chain consisting of atoms linked to each other by single bonds; unless otherwise specified, the remaining atomic valences are occupied by hydrogen atoms.

The terms "heterocyclic ring", "heterocycle" or "heterocyclic system" denote a ring or ring system in which at least one of the atoms forming the main chain of the ring is not carbon, for example nitrogen, oxygen or sulfur. Typically, a heterocyclic ring contains at most 4 nitrogen atoms, at most 2 oxygen atoms, and at most 2 sulfur atoms. Unless otherwise stated, a heterocyclic ring may be a saturated, partially unsaturated or fully unsaturated ring. When a fully unsaturated heterocyclic ring obeys its rule

MD 4889 B1 2024.03.31

Huckel, that ring is also called "heteroaromatic ring" or "aromatic heterocyclic ring". Unless otherwise indicated, rings and heterocyclic systems may be linked through any available carbon or nitrogen atom by replacing that carbon or nitrogen atom with a hydrogen atom.

The term "aromatic" indicates that each of the ring atoms is essentially in the same plane and has a p-type orbital perpendicular to the plane of the ring, and in which (4n + 2) π electrons, where n is a positive integer, are associated with the ring according to Huckel's rule. The term "aromatic ring system" denotes a carbocyclic or heterocyclic system in which at least one ring of the ring system is aromatic. The term "aromatic carbocyclic system" denotes a carbocyclic system in which at least one ring of the ring system is aromatic. The term "aromatic heterocyclic system" denotes a heterocyclic system in which at least one ring of the ring system is aromatic. The term "non-aromatic ring system" denotes a carbocyclic or heterocyclic system which may be fully saturated, as well as partially or fully unsaturated, provided that none of the rings in the ring system is aromatic. The term "non-aromatic carbocyclic system" denotes a carbocyclic system in which no ring of the ring system is aromatic. The term "non-aromatic heterocyclic system" denotes a heterocyclic system in which no ring of the ring system is aromatic.

The term "optionally substituted" in reference to heterocyclic rings refers to groups that are unsubstituted or have at least one non-hydrogen substituent that does not quench the biological activity possessed by the unsubstituted analog. The following definitions apply in this document unless otherwise indicated. The term "optionally substituted" is used interchangeably with the expression "substituted or unsubstituted" or with the term "(un)substituted". Unless otherwise indicated, an optionally substituted group may have a substituent at each substitutable position of the group, and each substitution is independent of the others.

When Q¹ sau Q²is a nitrogen-containing 5- or 6-membered heterocyclic ring, may be linked to the remainder of Formula 1 through any available carbon or nitrogen atom of the ring, unless otherwise stated. As stated above, Q¹ și Q²may be (among others) phenyl optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. An example of an optionally substituted phenyl with one to five substituents is the ring illustrated as U-1 in Example 1, wherein, for example, R^vis R7 as defined in the Summary of the Invention for Q¹, or Rv is R¹⁰as defined in the Summary of the Invention for Q², and r is an integer (from 0 to 5).

As stated above, Q¹ și Q²can be (among others) a 5- or 6-membered fully unsaturated heterocyclic ring optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. Examples of an unsaturated 5- or 6-membered aromatic heterocyclic ring optionally substituted with one or more substituents include rings U-2 through U-61 illustrated in Example 1, wherein R^vis any substituent as defined in the Summary of the Invention for Q¹ și Q², and r is an integer from 0 to 4, limited by the number of positions available in each grouping U. Since U-29, U-30, U-36, U-37, U-38, U-39, U -40, U-41, U-42, and U-43 have only one position available, for these U groups, r is limited to the integers 0 or 1, and when r is 0, the U group is unsubstituted, and an atom of hydrogen is present in

<td>the position indicated by (R^v)r. Example 1 (R'), 1 &lt;^r&gt;r Ό Ό; U-1 U-2 (R^v)r (R^v)r Ό Ό,</td><td>⁴ (R^v)R³ (R^v)R⁴ (R^v)r Ό'· -0' 2^^{S O} ' ^o-3 U-4 U-5^(RV)r^(RV)r^(RV)R Ό, 0²</td>

U-7

U-8

U-6

U-9

U-10

MD 4889 B1 2024.03.31

<img file="MD4889B1_D0002.tif" />

<img file="MD4889B1_D0003.tif" />

<img file="MD4889B1_D0004.tif" />

(R^v)R

<img file="MD4889B1_D0005.tif" />

<img file="MD4889B1_D0006.tif" />

U-11

U-12

<img file="MD4889B1_D0007.tif" />

<img file="MD4889B1_D0008.tif" />

r

<img file="MD4889B1_D0009.tif" />

U-18

U-14 (R^v)R

<img file="MD4889B1_D0010.tif" />

N—O

U-16

U-17

U-19 (R^v)_r

<img file="MD4889B1_D0011.tif" />

O—N

<img file="MD4889B1_D0012.tif" />

<img file="MD4889B1_D0013.tif" />

N³ (R^v)R

<img file="MD4889B1_D0014.tif" />

U-15

<img file="MD4889B1_D0015.tif" />

U-21

U-22

U-23 (R^v)R

<img file="MD4889B1_D0016.tif" />

<img file="MD4889B1_D0017.tif" />

<img file="MD4889B1_D0018.tif" />

N—N (R^v)R

<img file="MD4889B1_D0019.tif" />

<img file="MD4889B1_D0020.tif" />

N—N

U-26

U-27

U-28 U-29 U-30

<img file="MD4889B1_D0021.tif" />

U-36

<img file="MD4889B1_D0022.tif" />

<img file="MD4889B1_D0023.tif" />

<img file="MD4889B1_D0024.tif" />

N—N

U-32

N

o

N=Z (R^v)R

U-33

<img file="MD4889B1_D0025.tif" />

U-34

<img file="MD4889B1_D0026.tif" />

<img file="MD4889B1_D0027.tif" />

<img file="MD4889B1_D0028.tif" />

<img file="MD4889B1_D0029.tif" />

<img file="MD4889B1_D0030.tif" />

<img file="MD4889B1_D0031.tif" />

(R^v)R

<img file="MD4889B1_D0032.tif" />

(R^v)R

N=N

U-48

<img file="MD4889B1_D0033.tif" />

<img file="MD4889B1_D0034.tif" />

U-46

N—N

U-47

U-49

U-50

MD 4889 B1 2024.03.31

<img file="MD4889B1_D0035.tif" />

<img file="MD4889B1_D0036.tif" />

<img file="MD4889B1_D0037.tif" />

<img file="MD4889B1_D0038.tif" />

<img file="MD4889B1_D0039.tif" />

U-51

U-52

<img file="MD4889B1_D0040.tif" />

<img file="MD4889B1_D0041.tif" />

<img file="MD4889B1_D0042.tif" />

U-58

U-54

<img file="MD4889B1_D0043.tif" />

U-56

U-57

U-59

U-55

<img file="MD4889B1_D0044.tif" />

<img file="MD4889B1_D0045.tif" />

U-61

As stated above, Q¹ și Q²can be (among others) an 8-, 9- or 10-membered bicyclic heteroaromatic system optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention for Q¹ și Q². Examples of 8-, 9-, or 10-membered bicyclic heteroaromatic system 5 optionally substituted with one or more substituents include rings U-62 through U-100 illustrated in Example 2, wherein R^vis any substituent as defined in the Summary of the Invention for Q¹ sau Q², and r is typically an integer from 0 to 4. Example 2

<img file="MD4889B1_D0046.tif" />

<img file="MD4889B1_D0047.tif" />

U-64 U-65

<img file="MD4889B1_D0048.tif" />

<img file="MD4889B1_D0049.tif" />

<img file="MD4889B1_D0050.tif" />

U-68 U-69

<img file="MD4889B1_D0051.tif" />

<img file="MD4889B1_D0052.tif" />

<img file="MD4889B1_D0053.tif" />

U-74 U-75

<img file="MD4889B1_D0054.tif" />

MD 4889 B1 2024.03.31

<img file="MD4889B1_D0055.tif" />

<img file="MD4889B1_D0056.tif" />

<img file="MD4889B1_D0057.tif" />

<img file="MD4889B1_D0058.tif" />

U-89

<img file="MD4889B1_D0059.tif" />

N

<img file="MD4889B1_D0060.tif" />

-r(R^v)R

U-93

<img file="MD4889B1_D0061.tif" />

U-94 U-95 U-96 U-97

<img file="MD4889B1_D0062.tif" />

<img file="MD4889B1_D0063.tif" />

U-98 U-99 U-100

Although the groups R^vare shown in structures U-1 to U-100, it is noted that they are not required to be present as they are optional substituents. It should be noted that if R^vis H when bonded to an atom, this is equivalent to said atom being unsubstituted. Nitrogen atoms that require substitution to complete their valence are substituted with H or R^v. It should be noted that when the connection point between (R^v)_rand the group U is illustrated as floating, (R^v)r may be attached to any available carbon or nitrogen atom of the U group. It should be noted that when the point of attachment to the U group is illustrated as floating, the U group may be attached to the remainder of Formula 1 through any atom of carbon or nitrogen atom available from the U group, by replacing a hydrogen atom. Preferably, for the highest herbicidal activity, the U group is linked to the remainder of Formula 1 through an available carbon or nitrogen atom or a fully unsaturated ring of the U group. It should be noted that some U groups may be substituted exclusive with less than 4 R groupings^v(eg U-2 to U-5, U-7 to U-48 and U-52 to U-61).

In the present disclosure and claims, the term "pyrrolidinone" and associated terms such as "pyrrolidinone ring" refer to derivatives of 2-oxo-pyrrolidine according to the Chemical Abstracts cataloging system, including derivatives in which the oxygen atom of the 2-oxo moiety is replaced of S or NO¹²like Y¹, unless oxygen limited by a particular context.

A wide variety of synthetic methods for the preparation of aromatic and non-aromatic heterocyclic rings and systems are known in the art; for detailed articles, see the eight volumes of Comprehensive Heterocyclic Chemistry, general editors A. R. Katritzky and C. W. Rees, Pergamon Press, Oxford, 1984, and the twelve volumes of Comprehensive Heterocyclic

MD 4889 B1 2024.03.31

Chemistry II, Principal Editors A. R. Katritzky, C. W. Rees, and E. F. V. Scriven, Pergamon Press, Oxford, 1996.

The compounds of the present invention may exist as one or more stereoisomers. The different stereoisomers include enantiomers, diastereomers, atropisomers, and geometric isomers. Stereoisomers are isomers that have an identical composition, but differ in the arrangement of atoms in space; these include enantiomers, diastereomers, cis and trans isomers (also known as geometric isomers), and atropisomers. Atropisomers arise as a result of strict rotation around single bonds, where the rotational barrier is high enough to allow isolation of the isomeric species. One skilled in the art will appreciate that one stereoisomer may be more active and/or exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). In addition, one skilled in the art knows ways to separate, enrich and/or selectively prepare said stereoisomers. The compounds of the invention may be present as a mixture of stereoisomers, individual stereoisomers or as an optically active form. Especially when each of the R⁴și R⁵are H, the substituents C(O)N(Q²)(R⁶) and Q¹are mostly typically in the thermodynamically preferred trans configuration of the pyrrolidinone ring.

For example, the fraction C(O)N(Q²)(R⁶) (bonded to the carbon in the 3-position of the pyrrolidinone ring) and Q¹(bonded to the carbon in the 4-position of the pyrrolidinone ring) are generally found in the trans configuration. These two carbon atoms (namely in the 3 and 4 positions they each have in the pyrrolidinone ring of Formula 1) both possess a chirality center. The two prevalent pairs of enantiomers are described as Formula 1' and Formula 1, in which the centers of chirality are identified (namely as 3 R, 4 S or as 3 S, 4 R). While the present invention relates to all stereoisomers, the preferred pair of enantiomers for biological operability is identified as Formula 1' (namely the 3 R, 4 S configuration). For a comprehensive discussion of all aspects of stereoisomerism, see Ernest L. Eliel and Samuel H. Wilen, Stereochemistry of Organic Compounds, John Wiley &amp; Sons, 1994.

<img file="MD4889B1_D0064.tif" />

One skilled in the art will also recognize that the carbon atom in the 5-position of the pyrrolidinone ring (ie the carbon atom to which both R², as well as R³) also contains a stereocenter indicated by a (*) as described in Formula 1'''. The present invention relates to all stereoisomers and therefore when R² sau R³are different substituents, a mixture of diastereomers is possible.

<img file="MD4889B1_D0065.tif" />

Molecular descriptions in this document follow standard conventions for stereochemical description. To indicate the stereoconfiguration, the bonds that rise from the plane of the drawing toward the viewer are illustrated by solid triangles (wood splitting quill shape), where the base of the triangle is oriented toward the atom that rises from the plane of the drawing toward the viewer. Bonds that descend below the plane of the drawing and away from the viewer are illustrated by dashed triangles, where the apex of the triangle points to the atom that rises from the plane of the drawing toward the viewer. Lines of constant width indicate bonds with opposite or neutral direction to bonds illustrated by solid or dashed triangles; lines of constant width also indicate bonds in molecules or parts of molecules where no particular stereoconfiguration is intended to be specified.

MD 4889 B1 2024.03.31

The present invention also contains racemic mixtures, for example equal amounts of enantiomers having Formulas 1' and 1 (and optionally 1'''). In addition, the present invention includes compounds that are enriched, relative to the racemic mixture, in one enantiomer of Formula 1. Also included are essentially pure enantiomers of compounds of Formula 1, for example Formula 1' and Formula 1.

When enantiomerically enriched, one enantiomer is present in greater amounts than the other, and the degree of enrichment can be defined by expressing the enantiomeric ratio (ER) as a percentage of the relative surface area of the two enantiomers, determined by chiral high-performance liquid chromatography.

Preferably, the compositions of the present invention have an RE of at least 50%; more preferably, an RE of at least 75%; even more preferably, an RE of at least 90%; and most preferably, an RE of at least 94% of the most active isomer. Of particular note are the enantiomerically pure embodiments of the most active isomer.

Compounds of Formula 1 may contain additional centers of chirality. For example, substituents and other molecular constituents such as R², R³and R6 may also contain chirality centers. In these additional centers of chirality, the present invention contains racemic mixtures as well as substantially pure and enriched stereoconfigurations.

The compounds of the present invention may exist in one or more conformational isomers due to restricted rotation about the amide bond C(O)N(Q²)(R6) of Formula 1. The present invention contains mixtures of conformational isomers. Additionally, the present invention contains compounds that are enriched in one conformer relative to others. Compounds of Formula 1 typically exist in more than one form, and Formula 1 thus includes all crystalline and non-crystalline forms of the compounds it represents. Non-crystalline forms include solid embodiments such as waxes and gums as well as liquid embodiments such as solutions and melts. Crystalline forms include embodiments that are essentially a single type of crystal and embodiments that are a mixture of polymorphic forms (ie, different crystal forms). The term "polymorphic form" refers to a particular crystalline form of a chemical compound that can crystallize into different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice. Although polymorphic forms may have the same chemical composition, they may have different compositions due to the presence or absence of water or other co-crystallized molecules, which may be weakly or strongly bound in the crystal lattice. Polymorphic forms can be different in terms of chemical, physical and biological properties, such as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspendibility, dissolution rate and bioavailability. One skilled in the art will appreciate that a polymorphic form of a compound represented by Formula 1 may exhibit beneficial effects (eg, suitability for the preparation of useful formulations, high biological performance) over another polymorphic form or a mixture of polymorphic forms of the same compound represented by Formula 1. The preparation and isolation of a particular polymorphic form of a compound represented by Formula 1 can be accomplished by methods known to those skilled in the art, including, for example, crystallization using selected solvents and temperatures. For a detailed discussion of polymorphism, see R. Hilfiker, Ed., Polymorphism In the Pharmaceutical Industry, Wiley-VCH, Weinheim, 2006.

One skilled in the art will appreciate that not all nitrogen-containing heterocycles can form N-oxides, since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize nitrogen-containing heterocycles that can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for preparing N-oxides of heterocycles and tertiary amines are well known to those skilled in the art, including oxidation of heterocycles and tertiary amines with peroxy acids, such as peracetic acid and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl- hydroperoxides such as tert-butyl hydroperoxide, sodium perborate and dioxiranes such as dimethyldioxirane. These methods for the preparation of N-oxides have been described in detail and reviewed in the literature, such as: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp. 748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, vol 3, pp 18-20, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp. 149-161, A. R. Katritzky, Ed., Academic Press; m. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistry, vol 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp. 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.

One skilled in the art recognizes that because in the environment and under physiological conditions the salts of the chemical compounds are in equilibrium with the corresponding non-salt forms, the salts have the same biological utility as the non-salt forms. Thus, a wide variety of salts of the compounds having Formula 1 are useful for controlling unwanted vegetation (namely, they are suitable from

MD 4889 B1 2024.03.31 agricultural point of view). Salts of a compound of Formula 1 include salts of acids formed by addition with inorganic or organic acids, such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric. When a compound of Formula 1 contains an acidic moiety, such as a carboxylic acid or phenol, the salts also include those formed with organic or inorganic bases, such as pyridine, triethylamine or ammonia, or amides, hydrides, hydroxides or carbonates of sodium, potassium, lithium, calcium, magnesium or barium. Accordingly, the present invention consists of compounds selected from compounds of Formula 1, N-oxides and agriculturally suitable salts thereof.

The embodiments of the present invention described in the Summary of the Invention include the following (where Formula 1 used in the following Embodiments includes the N-oxides and salts thereof):

Embodiment 1. A compound according to Formula 1 wherein Q¹is an 8- to 10-membered bicyclic heteroaromatic system optionally substituted with R7 and R⁹, and the remainder of Formula 1 is linked to a fully unsaturated ring of said bicyclic system.

Embodiment 2. A compound according to Formula 1 or Embodiment 1 wherein Q¹is an optionally substituted phenyl ring with up to 5 substituents independently selected from R 7.

Embodiment 3. A compound according to Embodiment 2 wherein Q¹is a phenyl ring substituted with 1 to 3 substituents independently selected from R⁷.

Embodiment 4. A compound according to Embodiment 3 wherein Q¹is a phenyl ring substituted with 1 to 2 substituents independently selected from R⁷.

Embodiment 5. A compound according to Formula 1 or any of Embodiments 1 to 4, wherein Q¹is a phenyl ring having a substituent selected from R 7 in the para (4-) position (and optionally other substituents).

Embodiment 6. A compound according to Formula 1 or any of Embodiments 1 to 5 wherein Q¹is a phenyl ring having at least two substituents selected from R 7, then one substituent in the para (4-) position and at least one other substituent in the meta position (of the phenyl ring).

Embodiment 7. A compound according to Formula 1 or any of Embodiments 1 to 6, wherein Q²is an 8- to 10-membered bicyclic heteroaromatic system optionally substituted with R¹⁰ și R¹¹, and the remainder of Formula 1 is linked to a fully unsaturated ring of said bicyclic system.

Embodiment 8. A compound according to Formula 1 or any of Embodiments 1 to 7 wherein Q²is an optionally substituted phenyl ring with up to 5 substituents independently selected from R¹⁰.

Embodiment 9. A compound according to Embodiment 8 wherein Q²is a phenyl ring substituted with 1 to 3 substituents independently selected from R¹⁰.

Embodiment 10. A compound according to Embodiment 9 wherein Q²is a phenyl ring substituted with 1 to 2 substituents independently selected from R¹⁰.

Embodiment 11. A compound according to Formula 1 or any of Embodiments 1 to 10 wherein Q²is a phenyl ring having a substituent selected from R¹⁰in an ortho position (eg 2-) (and optionally other substituents).

Embodiment 12. A compound according to Formula 1 or any of Embodiments 1 to 11 wherein Q²is a phenyl ring having at least two substituents selected from R¹⁰, then at least one substituent is in an ortho position (eg 2-) and at least one substituent is in an adjacent meta position (eg 3-) (of the phenyl ring).

Embodiment 13. A compound according to Formula 1 or any of Embodiments 1 to 12 wherein, independently, each R7 and R¹⁰is independently halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl, C1-C4 nitroalkyl, C2-C4 Nitroalkenyl, C2-C4 Alkoxyalkyl, C2-C4 Haloalkoxyalkyl, C3-C4 Cycloalkyl, C3-C4 Halocycloalkyl, Cyclopropylmethyl, Methylcyclopropyl, C1-C4 Alkoxy, C1-C4 Haloalkoxy, C2-C4 Alkenyloxy, C2-C4 Haloalkenyloxy, C3-C4 Alkynyloxy, C3-C4 haloalkynyloxy, C3-C4 cycloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylsulfonyl, hydroxy, formyl, C2-C4 alkylcarbonyl, C2-C4 alkylcarbonyloxy, C1-C4 alkylsulfonyloxy, C1-C4 haloalkylsulfonyloxy, amino, C1-C4 alkylamino, C2-C4 dialkylamino, formylamino, C2-C4 alkylcarbonylamino, -SF5, -SCN, C3-C4 trialkylsilyl, trimethylsilylmethyl or trimethylsilylmethoxy.

Embodiment 14. A compound according to Embodiment 13 wherein each R⁷is independently halogen, cyano, C1-C2 alkyl, C1-C3 haloalkyl or C1-C3 alkylsulfonyl.

Embodiment 15. A compound according to Embodiment 14 wherein each R 7 is independently halogen or C 1 -C 2 haloalkyl.

MD 4889 B1 2024.03.31

Embodiment 16. A compound according to Embodiment 15 wherein each R⁷is independently halogen or C 1 haloalkyl.

Embodiment 17. A compound according to Embodiment 16 wherein each R⁷is independently halogen or C 1 fluoroalkyl.

Embodiment 18. A compound according to Embodiment 17 wherein each R⁷is independently halogen or CF 3.

Embodiment 19. A compound according to Embodiment 18 wherein each R⁷is independently F, Cl, Br or CF3.

Embodiment 20. A compound according to Embodiment 19 wherein each R⁷is independently F or CF3.

Embodiment 21. A compound according to Embodiment 19 or 20 wherein at most one CF3 substituent is present and is in the para position of the phenyl ring Q¹.

Embodiment 22. A compound according to any one of Embodiments 13 to 21, wherein each R¹⁰is independently halogen, cyano, nitro, C1-C2 alkyl, C1-C3 haloalkyl or C1-C3 alkylsulfonyl.

Embodiment 23. A compound according to Embodiment 22 wherein each R¹⁰is independently halogen or C1-C2 haloalkyl.

Embodiment 24. A compound according to Embodiment 23 wherein each R¹⁰is independently halogen or C1 haloalkyl.

Embodiment 25. A compound according to Embodiment 24 wherein each R¹⁰is independently halogen or C1 fluoroalkyl.

Embodiment 26. A compound according to Embodiment 25 wherein each R¹⁰is independently halogen or CF 3.

Embodiment 27. A compound according to Embodiment 26 wherein each R¹⁰is independently F, Cl, Br or CF3.

Embodiment 28. A compound according to Embodiment 27 wherein each R¹⁰is independently F or CF3.

Embodiment 29. A compound according to Embodiment 28 wherein each R¹⁰is f.

Embodiment 30. A compound according to Formula 1 or any of Embodiments 1 to 29 wherein, independently, each R⁹ și R¹¹is independently C 1 -C 2 alkyl.

Embodiment 31. A compound according to Embodiment 28 wherein, independently, each R⁹ și R¹¹is CH3.

Embodiment 32. A compound according to Formula 1 or any of Embodiments 1 to 31 wherein Y¹is a.

Embodiment 33. A compound according to Formula 1 or any of Embodiments 1 to 32 wherein Y²is a.

Embodiment 33a. A compound according to Formula 1 or any of Embodiments 1 to 33 wherein R¹is H, C1-C6 alkyl, C1-C6 haloalkyl or C4-C8 cycloalkylalkyl.

Embodiment 33b. A compound according to Formula 1 or any of Embodiments 1 to 33a wherein R¹is H, C1-C6 alkyl or C1-C6 haloalkyl.

Embodiment 33c. A compound according to Formula 1 or any of Embodiments 1 to 33b wherein R¹is H, Me, Et or CHF 2.

Form of realization 33d. A compound according to Formula 1 or any of Embodiments 1 to 33c wherein R¹is H, Me or Et.

Embodiment 34. A compound according to Formula 1 or any of Embodiments 1 to 33 wherein R¹is H or CH3.

Embodiment 34a. A compound according to Formula 1 or any of Embodiments 1 to 34 wherein R¹is CH3.

Embodiment 35. A compound according to Embodiment 34, wherein R¹is H

Embodiment 36. A compound according to Formula 1 or any of Embodiments 1 to 35 wherein R²is H or CH3.

Embodiment 37. A compound according to Embodiment 36, wherein R²is H

Embodiment 38. A compound according to Formula 1 or any of Embodiments 1 to 37 wherein R³is H or CH3.

Embodiment 39. A compound according to Embodiment 38, wherein R³is H

Embodiment 40. A compound according to Formula 1 or any of Embodiments 1 to 39 wherein R⁴is H or CH3.

MD 4889 B1 2024.03.31

Embodiment 41. A compound according to Embodiment 40, wherein R⁴is H

Embodiment 42. A compound according to Formula 1 or any of Embodiments 1 to 41 wherein R⁵is H or CH3.

Embodiment 43. A compound according to Embodiment 42, wherein R⁵is H

Embodiment 44. A compound according to Formula 1 or any of Embodiments 1 to 43 wherein R⁶is H or CH3.

Embodiment 45. A compound according to Embodiment 44, wherein R⁶is H

Embodiment 46. A compound according to Formula 1 or any of Embodiments 1 to 45 wherein Q²is different from the optionally substituted 1H-indazol-5-yl in the 3-position.

Embodiment 47. A compound according to Embodiment 46 wherein Q²is different from 1H-indazol-5-yl optionally substituted in the 1- and 3-positions.

Embodiment 48. A compound according to Embodiment 47 wherein Q²is different from optionally substituted 1H-indazol-5-yl.

Embodiment 49. A compound according to any one of Embodiments 1 to 48 wherein Q¹is different from unsubstituted phenyl.

Embodiment 50. A compound according to any one of Embodiments 1 to 49 wherein Q²is different from unsubstituted pyridinyl.

Embodiment 51. A compound according to any one of Embodiments 1 to 50 wherein Q¹is different from optionally substituted naphthalenyl.

Embodiment 56. A compound according to Formula 1 or any of Embodiments 1 to 51 wherein the stereochemistry is (3R, 4S) or (3S, 4R).

Embodiment 57. A compound according to Embodiment 51 wherein the stereochemistry is (3R, 4S).

Embodiment 58. A compound according to Embodiment 51 wherein the stereochemistry is (3S, 4R).

The embodiments of the present invention, including Embodiments 1-58 above, as well as any other embodiments described herein, may be combined in any manner, and the variable descriptions in the embodiments are not limited to compounds having Formula 1, but also to starting compounds and intermediate compounds useful for the preparation of compounds having Formula 1. In addition, embodiments of the present invention, including Embodiments 1-58 above, as well as any other embodiments described herein and any combination thereof, pertain to the compositions and methods of the present invention.

Combinations of Embodiments 1-58 are illustrated by:

Embodiment A. A compound of Formula 1 wherein each R⁹ și R¹¹is independently C 1 -C 2 alkyl.

Embodiment B. A compound according to Embodiment A, wherein each of Y¹ și Y²is a; and each R¹, R², R³, R⁴, R⁵ și R⁶is H

Embodiment C. A compound according to Embodiment B, wherein

Q¹is a phenyl ring substituted with 1 to 3 substituents independently selected from R 7; and Q²is a phenyl ring substituted with 1 to 3 substituents independently selected from R¹⁰.

Embodiment D. A compound according to Embodiment C, wherein each R 7 is independently halogen, cyano, C 1 -C 2 alkyl, C 1 -C 3 haloalkyl or C 1 -C 3 alkylsulfonyl; and each R¹⁰is independently halogen, cyano, nitro, C1-C2 alkyl, C1-C3 haloalkyl or C1-C3 alkylsulfonyl.

Embodiment E. A compound according to Embodiment D, wherein

Q¹is a phenyl ring substituted with 1 substituent selected from R⁷in the para position or substituted with 2 substituents independently selected from R⁷, where one substituent is in the para position and the other substituent is in the meta position; and

Q²is a phenyl ring substituted with 1 substituent selected from R¹⁰in the ortho position or substituted with 2 substituents independently selected from R¹⁰, where one substituent is in the ortho position and the other substituent is in the adjacent meta position.

Embodiment F. A compound according to Embodiment E, wherein each R 7 is independently F or CF 3; and each R¹⁰is f.

Specific embodiments include compounds of Formula 1 selected from the group consisting of: N-(2,3-difluorophenyl)-4-(3,4-difluorophenyl)-2-oxo-3-pyrrolidinecarboxamide (Compound 17);

MD 4889 B1 2024.03.31

N-(2-fluorophenyl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 79);

N-(2,3-difluorophenyl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 80);

N-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide (Compound 5); and (3R,4S)-N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound

204).

Specific embodiments include a compound of Formula 1 selected from the group consisting of Compounds having the numbers (where the compound numbers refer to compounds in Index Tables A, B or C): 80, 202, 204, 206, 232, 263, 304, 306, 315 and 319; or 202, 206, 232, 304 and 306; or 202, 232 and 306.

Specific embodiments include a compound of Formula 1 selected from the group consisting of Compounds having the numbers (where the compound numbers refer to compounds in Index Tables A, B or C): 3, 5, 17, 101, 103, 156, 204, 271, 323 and 351; or 3, 17, 103, 156, and 204; or 103, 204 and 351.

The present invention also relates to a method for controlling unwanted vegetation consisting of applying to the site of the vegetation herbicidally effective amounts of the compounds of the invention (eg in the form of a composition described herein). As embodiments associated with the methods of use, those that refer to the compounds according to the embodiments described above are noted. The compounds of the invention are particularly useful for selective weed control in crops such as wheat, barley, corn, soybeans, sunflower, cotton, canola and rice, and in specialty crops such as sugar cane, lemons, fruits and berries. woody bark.

Herbicidal compositions of the present invention consisting of the compounds according to the embodiments described above should also be noted as embodiments.

The present invention also includes a herbicidal mixture consisting of (a) a compound selected from Formula 1, N-oxides and salts thereof, and (b) at least one additional active ingredient selected from (b1) photosystem II inhibitors, (b2) acetohydroxy-acid synthase (AHAS) inhibitors, (b3) acetyl-CoA carboxylase (ACC-ase) inhibitors, (b4) auxin analogues, (b5) 5-enolpyruvylshikimate-3-phosphate synthase inhibitors (EPSP), (b6) deviators of photosystem I electrons, (b7) protoporphyrinogen oxidase (PPO) inhibitors, (b8) glutamine synthetase (GS) inhibitors, (b9) very long chain fatty acid elongase (VLCFA) inhibitors, (b10) auxin transport inhibitors, (b11) phytoene-desaturase (PDS) inhibitors, (b12) 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors, (b13) homogentisate-solensyltranserase (HST) inhibitors, (b14) cellulose biosynthesis inhibitors, (b15) other herbicides, including mitosis inhibitors, organoarsenic compounds, asulam, brombutide, cinmethylin, cumiluron, dazomet, difenzoquat, dimron, ethobenzanide, flurenol, fosamine, fosamine-ammonium, metam, methyldimron, oleic acid, oxaziclomefon, pelargonic acid and pyributicarb, and (b16) phytoprotective adjuvants against herbicides; and salts of compounds (b1) to (b16).

"Photosystem II inhibitors" (b1) are chemical compounds that bind to the D-1 protein and the Qb-binding niche and thus block the transport of electrons from Qa to Qb in the tykaloid membrane of chloroplasts. Electrons that are blocked from passing through photosystem II are transferred through a series of reactions to form toxic compounds that destroy cell membranes and cause chloroplast inflammation, membrane leakage, and ultimately cell death. The Qb binding niche involves three different binding sites: the A binding site binds triazines such as atrazine, triazinones such as hexazinone, and uracils such as bromacil, the B binding site binds phenylureas such as diuron, and the C binding site binds benzothiadiazoles, such as bentazone, nitriles such as bromoxynil, and phenylpyridazines such as pyridate. Examples of photosystem II inhibitors include ametrin, amicarbazone, atrazine, bentazon, bromacil, bromphenoxime, bromoxynil, chlorbromuron, chloridazone, chlortoluron, chloroxuron, cumiluron, cyanazine, daimuron, desmedipham, desmethrin, dimefuron, dimetamethrin, diuron, etidimuron, fenuron, fluometuron, hexazinone, ioxinil, isoproturon, isouron, lenacil, linuron, metamitron, metabenzthiazuron, metobromuron, metoxuron, metribuzin, monolinuron, neburon, pentanochlor, fenmedipham, prometon, promethrin, propanil, propazine, pyridafol, pyridate, siduron, simazine, symmetrin, tebuthiuron, terbacil, terbumeton, terbuthylazine, terbutrin and triethazine.

"AHAS inhibitors" (b2) are chemical compounds that inhibit acetohydroxy-acid synthase (AHAS), also known as acetolactate synthase (ALS), and thus kill plants by inhibiting branched-chain aliphatic amino acids such as valine, leucine and isoleucine, which are required for protein synthesis and cell growth. Examples of AHAS inhibitors include amidosulfuron, azimsulfuron, bensulfuron-methyl, bispyribac-sodium, chloransulam-methyl, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, cyclosulfamuron, diclosulam, etametsulfuron-methyl, ethoxysulfuron, flazasulfuron, florasulam, flucarbazone-sodium, flumetsulam, flupirsulfuron-methyl, flupirsulfuron-sodium, foramsulfuron, halosulfuron-methyl, imazametabenz-methyl, imazamox, imazapic, imazapyr, imazaquin, imazethapyr,

MD 4889 B1 2024.03.31 imazosulfuron, iodosulfuron-methyl (including sodium salt), iofensulfuron (2-iodo-N-[[(4-methoxy-6-methyl1, 3, 5-triazin-2-yl)amino]carbonyl] benzenesulfonamide), mesosulfuron-methyl, metazosulfuron (3-chloro4-(5, 6-dihydro-5-methyl-1, 4, 2-dioxazin-3-yl)-N-[[(4, 6-dimethoxy-2- pyrimidinyl)amino]carbonyl]-1-methyl1H-pyrazole-5-sulfonamide), metosulam, metsulfuron-methyl, nicosulfuron, oxasulfuron, penoxsulam, primisulfuron-methyl, propoxycarbazone-sodium, propirisulfuron (2-chloro-N-[[(4, 6-dimethoxy-2pyrimidinyl)amino]carbonyl]-6-propylimidazo[1, 2- b ]pyridazine-3-sulfonamide), prosulfuron, pyrazosulfuron-ethyl, pyribenzoxime, pyriphthalide, pyriminobac-methyl, pyrithiobac-sodium, rimsulfuron, sulfometuron-methyl, sulfosulfuron, thiencarbazone, thifensulfuron-methyl, triafamone (N-[2-[(4, 6-dimethoxy1, 3, 5-triazin-2-yl)carbonyl] -6-fluorophenyl]-1, 1 -difluoro-N-methylmethanesulfonamide), triasulfuron, tribenuron-methyl, trifloxysulfuron (including sodium salt), triflusulfuron-methyl and tritosulfuron.

"ACC-ase inhibitors" (b3) are chemical compounds that inhibit the enzyme acetyl-CoA carboxylase, which is responsible for catalyzing an early step in the synthesis of lipids and fatty acids in plants. Lipids are essential components of cell membranes and without them new cells cannot be produced. Inhibition of acetylCoA carboxylase and subsequent lack of lipid production leads to loss of cell membrane integrity, particularly in regions of active growth such as meristems. Eventually, shoot and rhizome growth ceases, and shoot meristems and rhizome buds begin to dry out. Examples of inhibitor! of ACC-ase include aloxidim, butroxidim, clethodim, clodinafop, cycloxidim, cihalofop, diclofop, fenoxaprop, fluazifop, haloxyfop, pinoxaden, profoxidim, propaquizafop, quizalofop, sethoxidim, tepraloxidim and tralkoxidim, including separate forms such as fenoxaprop-P, fluazifop- P, haloxyfop-P and quizalofop-P and the ester forms, such as clodinafop-propargyl, cihalofop-butyl, diclofop-methyl and fenoxaprop-P-ethyl.

Auxin is a plant hormone that regulates growth in many plant tissues. "Auxin analogs" (b4) are chemical compounds that mimic the plant growth hormone auxin, thereby causing uncontrolled and disordered growth that leads to plant death in susceptible species. Examples of auxin analogs include aminocyclopyrachlor (6-amino-5-chloro-2-cyclopropyl-4-pyrimidinecarboxylic acid) and its methyl and ethyl esters and its sodium and potassium salts, aminopyralid, benazolin-ethyl, chloramben, claciphos, clomeprop, clopyralid, dicamba, 2, 4-D, 2, 4-DB, dichlorprop, fluroxypyr, halauxifen (4-amino3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylic acid), haloxifen-methyl (methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylate), MCPA, MCPB, mecoprop, picloram, quinclorac, quinmerac, 2, 3, 6-TBA, triclopyr and methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2pyridinecarboxylate.

"(EPSP) (5-enol-pyruvylshikimate-3-phosphate)-synthase inhibitors" (b5) are chemical compounds that inhibit the enzyme 5-enol-pyruvylshikimate-3-phosphate-synthase, which is involved in the synthesis of amino acids such as tyrosine, tryptophan and phenylalanine. EPSP-inhibiting herbicides are rapidly absorbed through plant foliage and translocated into the phloem of growing points. Glyphosate is a relatively non-selective post-emergence herbicide that belongs to this group. Glyphosate includes esters and salts, such as ammonium, isopropylammonium, potassium, sodium (including sesquisodium), and trimesium (alternatively called sulfosate).

"Photosystem I electron scavengers" (b6) are chemical compounds that accept electrons from photosystem I, and after a few cycles generate hydroxyl radicals. These radicals are highly reactive and rapidly destroy unsaturated lipids, including membrane fatty acids and chlorophyll. Thus the integrity of the cell membrane is destroyed, so that the cells and organelles "leak", leading to the rapid wilting and dehydration of the leaves and finally to the death of the plant. Examples of this second type of photosynthesis inhibitor include diquat and paraquat.

"PPO inhibitors" (b7) are chemical compounds that inhibit the enzyme protoporphyrinogen oxidase, rapidly causing the formation of highly reactive compounds in plants that rupture the cell membrane, causing leakage of cell fluids. Examples of PPO inhibitors include acifluorfen-sodium, azafenidine, benzfendizone, bifenox, butafenacil, carfentrazone, carfentrazone-ethyl, clomethoxifene, cinidone-ethyl, fluazolate, flufenpyr-ethyl, flumiclorac-pentyl, flumioxazin, fluoroglycophen-ethyl, fluthiacet-methyl, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazone, oxyfluorfen, pentoxazone, profluazole, pyraclonil, pyraflufen-ethyl, saflufenacil, sulfentrazone, thidiazimin, thiaphenacil (methyl N-[2-[[2chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2 H)-pyrimidinyl]-4-fluorophenyl] thio]-1oxopropyl|-(i-alaninate) and 3-[7-fluoro-3, 4-dihydro-3-oxo-4-(2-propyn-1-yl)-2 H-1, 4-benzoxazin- 6yl]dihydro-1,5-dimethyl-6-thioxo-1,3,5-triazine-2,4(1H,3H)-dione.

"GS (glutamine synthase) inhibitors" (b8) are chemical compounds that inhibit the activity of the enzyme glutamine synthetase, which plants use to convert ammonia into glutamine. As a result, ammonia accumulates and glutamine concentration decreases. Plant damage probably occurs due to the combined effects of ammonia toxicity and deficiency of amino acids needed for other metabolic processes. GS inhibitors include glufosinate and its esters and salts, such as glufosinate-ammonium and other phosphinothricin derivatives, glufosinate-P ((2 S)-2-amino-4(hydroxymethylphosphinyl)butanoic acid) and bilanaphos.

MD 4889 B1 2024.03.31 "VLCFA (very long chain fatty acid elongase) inhibitors" (b9) are herbicides that possess a wide range of chemical structures and that inhibit elongase. Elongase is one of the enzymes located in or near chloroplasts that are involved in VLCFA biosynthesis. In plants, very long-chain fatty acids are the main constituents of hydrophobic polymers that prevent dehydration of the leaf surface and ensure the stability of pollen grains. Such herbicides include acetochlor, alachlor, anilophos, butachlor, cafestrol, dimethachlor, dimethenamid, diphenamide, phenoxasulfone (3-[[(2, 5-dichloro-4ethoxyphenyl)methyl]sulfonyl]-4, 5-dihydro-5, 5- dimethylisoxazole), fentrazamide, flufenacet, indanophan, mefenacet, metazachlor, metolachlor, naproanilide, napropamide, napropamide-M ((2R)-N, N-diethyl-2-(1naphthalenyloxy)propanamide), petoxamide, piperofos, pretylachlor, propachlor, propizochlor, pyroxasulfone and tenylchlor, including separate forms, such as S-metolachlor and chloracetamides and oxyacetamides.

"Auxin transport inhibitors" (b10) are chemicals that inhibit auxin transport in plants, such as by binding to an auxin transport protein. Examples of auxin transport inhibitors include diflufenzopyr, napthalam (also known as N-(1-naphthyl)phthalamic acid and 2-[(1-naphthalenylamino)carbonyl]benzoic acid).

"PDS (phytoene desaturase) inhibitors" (b11) are chemical compounds that inhibit the carotenoid biosynthesis pathway at the phytoene desaturase step. Examples of PDS inhibitors include beflubutamide, diflufenican, fluridone, flurochloridone, flurtamone, norflurzone, and picolinafen.

"HPPD (4-hydroxyphenylpyruvate dioxygenase) inhibitors" (b12) are chemicals that inhibit the biosynthesis of 4-hydroxyphenylpyruvate dioxygenase. Examples of HPPD inhibitors include benzobicyclone, benzofenap, bicyclopyrone (4-hydroxy-3-[[2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)3-pyridinyl]carbonyl]bicyclo[3.2.1]oct- 3-en-2-one), phenquinotrione (2-[[8-chloro-3, 4-dihydro-4-(4-methoxyphenyl)-3oxo-2-quinoxalinyl]carbonyl]-1, 3-cyclohexanedione), isoxachlorotol, isoxaflutole, mesotrione, pyrasulphotol, pyrazolinate, pyrazoxifene, sulcotrione, tefuryltrione, tembotrione, toprameson, 5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1 H)-quinoxalinone, 4-(2,6-diethyl- 4-methylphenyl)-5-hydroxy-2,6dimethyl-3(2H)-pyridazinone, 4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl] -2-methyl-1,2,4triazine-3,5(2H,4H)-dione, 5-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-(3- methoxyphenyl)-3-(3methoxypropyl)-4(3H)-pyrimidinone, 2-Methyl-N-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(methylsulfinyl)-4-(trifluoromethyl)benzamide and 2-methyl-3-(methylsulfonyl)-N-(1 -methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide.

HST (homogentisate-solensyltranserase) inhibitors (b13) disrupt a plant's ability to convert homogentisate to 2-methyl-6-solanyl-1, 4-benzoquinone, thereby disrupting carotenoid biosynthesis. Examples of HST inhibitors include haloxidine, pyrichlor, 3-(2-chloro-3,6-difluorophenyl)-4hydroxy-1-methyl-1,5-naphthyridin-2(1 H)-one, 7-(3,5 -dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8hydroxypyrido[2,3-b]pyrazin-6(5H)-one and 4-(2,6-diethyl-4-methylphenyl)- 5-hydroxy-2, 6-dimethyl-3(2 H) pyridazinone.

HST inhibitors also include compounds of Formulas A and B.

in which R^d1is H, Cl or CF3; Rd²is H, Cl or Br; Rd³is H or Cl; Rd⁴is H, Cl or CF3; Rd⁵is CH3, CH2CH3 or CH2CHF2; and Rd⁶is OH or -OC(=O)-i -Pr; and R^e1 este H, F, Cl, CH3 sau CH2CH3; R^e2is H or CF3; R^e3is H, CH3 or CH2CH3; R^e4 este H, F sau Br; R^e5is Cl, CH3, CF3, OCF3 or CH2CH3; R^e6is H, CH3, CH2CHF2 or CCH; Re⁷ este OH, -OC(=O)Et, -OC(=O)-i-Pr sau -OC(=O)-1-Bu; iar A^e8is N or CH.

Cell biosynthesis inhibitors (b14) inhibit cellulose biosynthesis in certain plants. They are most effective when pre-applied or early post-applied on young or fast-growing plants. Examples of cellulose biosynthesis inhibitors include chlorthiamide, diclobenil, flupoxam, indaziflam (N²-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-(1-fluoroethyl)-1,3,5-triazine2,4-diamine), isoxaben and triaziflam.

Other herbicides (b15) include herbicides that act through a variety of modes of action, such as mitosis inhibitors (eg flamprop-M-methyl and flamprop-M-isopropyl), organoarsenic compounds (eg DSMA and MSMA), inhibitors of 7, 8-dihydropteroate synthase, inhibitors of chloroplast MD 4889 B1 2024.03.31 isoprenoid synthesis and inhibitors of cell wall biosynthesis. Other herbicides include herbicides that have unknown modes of action, that do not fall into a specific category listed in (bl) to (b14), or that act by a combination of the modes of action listed above. Examples of other herbicides include aclonifen, asulam, amitrol, brombutide, cinmethylene, clomazon, cumiluron, cyclopyrimorate (6-chloro-3-(2cyclopropyl-6-methylphenoxy)-4-pyridazinyl 4-morpholinecarboxylate), daimuron, difenzoquat, etobenzanid, fluometuron, flurenol, fosamine, fosamine-ammonium, dazomet, dimron, ipfencarbazone (1-(2, 4-dichlorophenyl)- N (2, 4-difluorophenyl)-1, 5-dihydro-N-(1 -methylethyl)-5- oxo-4H-1, 2, 4-triazole-4-carboxamide), metam, methyldimron, oleic acid, oxaziclomefon, pelargonic acid, pyributicarb and 5-[[(2, 6-difluorophenyl)methoxy]methyl]-4, 5-dihydro-5methyl-3-(3-methyl-2-thienyl)isoxazole.

"Herbicide phytoprotective adjuvants" (b16) are substances added to the herbicide formulation to eliminate or reduce the phytotoxic effects of the herbicide on certain crops. These compounds protect crops from herbicide damage, but typically do not prevent herbicides from controlling unwanted vegetation. Examples of herbicide phytoprotective adjuvants include, but are not limited to, benoxacor, cloquintocet-mexyl, cumiluron, cyometrinil, cyprosulfamide, daimuron, dichlormid, dicyclonon, dimepiperate, fenchlorazole-ethyl, fenchlorim, flurazol, fluxofenim, furilazole, isoxadifen-ethyl, mefenpyr-diethyl, mefenate, methoxyphenone, naphthalic anhydride, oxabetrinil, N-(aminocarbonyl)-2-methylbenzenesulfonamide and N(aminocarbonyl)-2-fluorobenzenesulfonamide, 1-bromo-4-[(chloromethyl)sulfonyl]benzene, 2-(dichloromethyl)-2-methyl1, 3-dioxolane (MG 191), 4-(dichloroacetyl)-1-oxa-4-azospiro[4.5]decane (MON 4660).

Compounds of Formula 1 may be prepared by general methods known in the art of synthetic organic chemistry. The following methods described in Schemes 1—15 and their variations are of note. The definitions regarding R¹, R², R³, R⁴, R⁵, R⁶, Q¹, Q², Y¹ și Y²in compounds according to Formulas 1 to 19 below are those previously set forth in the Summary of the Invention, unless otherwise specified. Formulas 1a—1h and 5a and 10a are various subsets of the compounds of Formulas 1, 5, and 10, respectively. Substituents for each formula of a subset conform to the definition for the parent formula unless otherwise noted.

As shown in Scheme 1, compounds having Formula 1a (namely Formula 1 wherein R¹, R⁴ și R⁵are H and Y¹ și Y²are O) can be prepared by reacting acids of Formula 2 with amines of Formula 3 in the presence of a dehydrating coupling reagent such as propylphosphonic anhydride, dicyclohexylcarbodiimide, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide, N,N'-carbonyldiimidazole, 2-chloro-1,3-dimethylimidazolium chloride or 2-chloro-1-methylpyridinium iodide. Polymer-supported reagents such as cyclohexylcarbodiimide are also suitable. These reactions typically occur at temperatures between 0 and 60 °C in a solvent such as dichloromethane, acetonitrile, N,N-dimethylformamide or ethyl acetate in the presence of a base such as triethylamine, N,N-diisopropylamine or 1,8- diazabicyclo[5.4.0]undec-7-ene. For coupling conditions using propylphosphonic anhydride, see Organic Process Research &amp; Development 2009, 13, 900—906. The method of Scheme 1 using propylphosphonic anhydride is illustrated by Step E of Synthesis Example 1. The substituents in positions 3 and 4 of the pyrrolidinone ring of compounds having Formula 1a, namely C(O)N(Q²)(R⁶) and Q respectively¹is predominantly in the trans configuration. In some cases, the presence of minor amounts of the cis isomer can be detected by NMR.

Scheme 1

Q²

HN^z_YQ²^QL7~^OH R⁶wow

- κίΠ⁶

r^3&gt;y4 reagent/base

I coupling । dehydrating pj la

As shown in Scheme 2, compounds of Formula 2 can be prepared by hydrolysis of esters of Formula 4 by methods well known to those skilled in the art. The hydrolysis is carried out with an aqueous base or aqueous acid, typically in the presence of a co-solvent. Suitable bases for the reaction include, but are not limited to, hydroxides, such as sodium hydroxide and potassium hydroxide, and carbonates, such as sodium carbonate and potassium carbonate. Suitable acids for the reaction include, but are not limited to, inorganic acids such as hydrochloric acid, hydrobromic acid and sulfuric acid, and organic acids such as acetic acid and trifluoroacetic acid. A wide variety of co-solvents are suitable for the reaction, including but not limited to methanol, ethanol and tetrahydrofuran. The reaction is carried out at temperatures between -20 °C and the boiling point of the solvent and typically between 0 and 100 °C. The method of Scheme 2 is illustrated by Step D of Synthesis Example 1.

MD 4889 B1 2024.03.31

Scheme 2

<img file="MD4889B1_D0066.tif" />

As shown in Scheme 3, compounds of Formula 4 can be obtained by reduction of compounds of Formula 5 and subsequent in situ cyclization of the resulting amine intermediate. A wide variety of methods for the reduction of the nitroaliphatic group in compounds of Formula 5 are known in the literature. Methods well known to those skilled in the art include catalytic hydrogenation in the presence of palladium on carbon or Raney nickel, iron or zinc in acidic media (see, for example, Berichte der Deutschen Chemischen Gesellschaft 1904, 37, 3520-3525), and lithium aluminum hydride. The reduction can also be accomplished with samarium(II) iodide in the presence of a proton source such as methanol (see, for example, Tetrahedron Letters 1991, 32 (14), 1699-1702). Alternatively, sodium borohydride can be used in the presence of a catalyst such as nickel(II) acetate or nickel(II) chloride (see, for example, Tetrahedron Letters 1985, 26 (52), 6413-6416). The method described in Scheme 3, which uses sodium borohydride in the presence of nickel(II) acetate, is illustrated by Step C of Synthesis Example 1.

Specific examples of a compound having Formula 4 Formula 1 can be found in Tables I through IV.

Scheme 3 useful in the preparation of a compound having which is

<img file="MD4889B1_D0067.tif" />

As described in Scheme 4, compounds of Formula 5 can be prepared by reacting diesters of Formula 6 with nitroalkanes of Formula 7, typically in the presence of a base. Suitable bases for the reaction include lower alkali metal alkoxides such as sodium methoxide in methanol or sodium ethoxide in ethanol. The method of Scheme 4 is illustrated by Step B of Synthesis Example 1. Compounds of Formula 6 can be prepared rapidly by methods known to those skilled in the art, for example by the Knoevenagel condensation of aldehydes and malonates (see, for example, G. Jones, Organic Reactions Volume 15, John Wiley and Sons, 1967). Scheme 4

Q¹

<img file="MD4889B1_D0068.tif" />

•₂R'

Co₂R'

r³r²CHNO₂

r

R' is lower alkyl

r

<img file="MD4889B1_D0069.tif" />

^R' *₂R*

Compounds having Formula 5a (namely Formula 5 in which R² și R³are H) can be prepared by reacting nitroalkenes of Formula 8 with malonates of Formula 9 in the presence of a base as described in Scheme 5. Suitable bases for this reaction include, but are not limited to, lower alkali metal alkoxides such as methoxide sodium in methanol or sodium ethoxide in ethanol, or bases such as lithium bis(trimethylsilyl)amide, sodium bis(trimethylsilyl)amide and lithium diisopropylamide in solvents such as tetrahydrofuran. Typically, the reaction occurs in the temperature range of -78 °C to 23 °C. See Synthesis 2005, 2239-2245 for the conditions for performing this transformation. Conditions for performing this transformation in refluxing heated water in the absence of a catalyst were reported in Synthetic Communications 2013, 43, 744-748. Nitroalkanes

MD 4889 B1 2024.03.31 having Formula 8 can be rapidly prepared from aldehydes and nitromethane by methods known to those skilled in the art.

Scheme 5

<img file="MD4889B1_D0070.tif" />

Compounds of Formula 5a' and 5a'' can be stereoselectively prepared by reacting nitroalkenes of Formula 8 with malonates of Formula 9 in the presence of a chiral catalyst and, optionally, in the presence of a suitable base, as described in Scheme 5A. Suitable catalysts include, but are not limited to, Ni(II) with vicinal diamine ligands, such as Ni(II) Bis[(R, R)-N,N'-dibenzylcyclohexane-1,2-diamine]dibromide, Ni(II) Bis[(S,S)-N,N-dibenzylcyclohexane-1,2-diamine]dibromide or nickel(II) bromide with chiral diamines 1,1'-bi(tetrahydroisoquinoline). Suitable organic bases for this reaction include, but are not limited to, piperidine, morpholine, triethylamine, 4-methylmorpholine, or N,N-diisopropylethylamine. This transformation can be completed without solvents or in solvents such as tetrahydrofuran, toluene or dichloromethane. Typically, the reaction is carried out in the temperature range of -78 °C to 80 °C, using between 0 and 1 equivalent of a catalyst and optionally between 0 and 1 equivalent of a base. The conditions for performing this transformation were reported in J. Am. Chem. Shock. 2005, 9958-9959 or Eur. J. Org. Chem. 2011, 54415446 for conditions. Nitroalkanes of Formula 8 can be rapidly prepared from aldehydes and nitromethane by methods known to those skilled in the art. Scheme 5A

<img file="MD4889B1_D0071.tif" />

As depicted in Scheme 6, compounds of Formula 1a can also be prepared by reductive cyclization of compounds of Formula 10, analogously to the method of Scheme 3. As depicted in Scheme 6, compounds of Formula 1b (namely Formula 1 in which R¹is OH, R⁴ și R⁵are H and Y¹ și Y²are O) can be prepared from compounds of Formula 10 by catalytic transfer hydrogenation with ammonium formate in the presence of palladium on carbon and subsequent in situ cyclization of the hydroxylamine intermediate. See J. Med. Chem. 1993, 36, 1041-1047 for catalytic transfer/cyclization hydrogenation conditions for the production of N-hydroxypyrrolidinones. The method of Scheme 6 for the preparation of N-hydroxypyrrolidinones is illustrated by Step D of Synthesis Example 3.

Scheme 6

<img file="MD4889B1_D0072.tif" />

OH lb

MD 4889 B1 2024.03.31

As described in Scheme 7, compounds of Formula 10 can be prepared by reacting compounds of Formula 11 with nitroalkanes of Formula 7, typically in the presence of a base, analogous to the method described in Scheme 4. The method of Scheme 7 is illustrated by Step C of Synthesis Example 3.

Scheme 7

<img file="MD4889B1_D0073.tif" />

Co₂R' r³r²CHNO₂

<img file="MD4889B1_D0074.tif" />

As depicted in Scheme 8, compounds of Formula 10a (namely Formula 10 wherein R² și R³are H) can be prepared, analogously to the method in Scheme 5, by reacting nitroalkenes of Formula 8 with malonates of Formula 12.

Scheme 8

<img file="MD4889B1_D0075.tif" />

As shown in Scheme 9, compounds of Formula 11 can be prepared by reacting malonic amide of Formula 12 with aldehydes of Formula 14 by methods known to those skilled in the art. As shown in Scheme 9, malonates of Formula 12 can be rapidly prepared from lower alkylmalonyl chlorides of Formula 13, such as methylmalonyl chloride and amines of Formula 3 by methods known to those skilled in the art. The method of Scheme 9 is illustrated by Steps A and B of Synthesis Example 3. Scheme 9

<img file="MD4889B1_D0076.tif" />

As shown in Scheme 10, mixtures of compounds having Formula 1c (namely Formula 1 wherein R¹ și R⁵I am H, R⁴is halogen, and Y¹ și Y²are O) and Formula 1d (namely Formula 1 in which R¹ și R⁴I am H, R⁵is halogen, and Y¹ și Y²are O) can be prepared by reacting compounds of Formula 1a with a halogen source in a solvent, in the presence or absence of an initiator. Separation of the regioisomers produced in this reaction can be accomplished by standard methods such as chromatography or fractional crystallization. Suitable halogen sources for this reaction include bromine, chlorine, N-chlorosuccinimide, N-bromosuccinimide, and N-iodosuccinimide. Suitable initiators for this reaction include 2,2'azobisisobutyronitrile (AIBN) and benzoyl peroxide. Typically, the reaction takes place in solvents such as dichloromethane in the temperature range from 0 °C to the boiling point of the solvent. The method of Scheme 10 is illustrated by Synthesis Example 2.

Scheme 10

MD 4889 B1 2024.03.31

<img file="MD4889B1_D0077.tif" />

As shown in Scheme 11, compounds having Formula 1e (namely Formula 1 in which R¹is NH2, R⁴ și R⁵are H and Y¹ și Y²are O) can be prepared by reacting compounds of Formula 1a with an amination reagent such as O-(diphenylphosphinyl)hydroxylamine and hydroxylamino-O-sulfonic acid. For procedures, conditions and reagents, see Bioorganic &amp; Medicinal Chemistry Letters 2009, 19, 5924-5926 and Journal of Organic Chemistry 2002, 67, 6236-6239. Scheme 11

<img file="MD4889B1_D0078.tif" />

to them

As shown in Scheme 12, compounds having Formula 1f (namely Formula 1 in which R⁴, R⁵ și R⁶are H and Y¹is O) can be produced by reacting compounds of Formula 15 with isocyanates (namely Formula 16 where Y²is O) or isothiocyanates (namely Formula 16 where Y²is S) in the presence of a base. Examples of bases that can be used in this process include those listed for the method in Scheme 4. The reaction temperature can be selected from the range of -78 °C to the boiling point of the inert solvent used. Typically, the reaction is carried out at temperatures in the range of -78 °C to 100 °C in solvents such as toluene.

Scheme 12

<img file="MD4889B1_D0079.tif" />

As described in Scheme 13, compounds of Formula 15 can be prepared by reacting compounds of Formula 17 with corresponding electrophiles of Formula 18 in the presence of a base. In Formula 18, G denotes a fugitive group, for example nucleofugous. Depending on the selection of R 1, suitable electrophiles for the reaction may include alkyl halides, such as chlorides, bromides, and iodides, alkylsulfonates, acid anhydrides, such as tert-butoxycarbonyl anhydride and acetic anhydride, and haloalkylsilanes, such as chlorotrimethylsilane. Suitable bases for the reaction include inorganic bases such as alkali metals or alkaline earth metals (eg lithium, sodium, potassium and cesium), hydroxides, alkoxides, carbonates and phosphates, and organic bases such as triethylamine, N,N-diisopropylethylamine and 1, 8-diazabicyclo[5.4.0]undec-7ene. A wide range of solvents that are suitable for the reaction include, for example, but not limited to, tetrahydrofuran, dichloromethane, N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidinone, acetonitrile, C2-C6 alcohols and acetone, as well as mixtures of these solvents. This reaction takes place at temperatures in the range of -20 to 200 °C, and typically between 0 and 50 °C.

Scheme 13

MD 4889 Bl 2024.03.31

<img file="MD4889B1_D0080.tif" />

<img file="MD4889B1_D0081.tif" />

As shown in Scheme 14, compounds of Formula 17 can be prepared by decarboxylation of acids of Formula 2 by methods well known to those skilled in the art. Decarboxylation is accomplished by heating compounds of Formula 2 in a solvent, typically in the presence of an acid. Suitable acids for the reaction include, but are not limited to, p-toluenesulfonic acid. A wide variety of co-solvents are suitable for the reaction, including, but not limited to, toluene, isopropanol acetate, and isobutyl methyl ketone. The reaction is carried out at temperatures between -20 °C and the boiling point of the solvent, and typically between 0 and 150 °C. The method of Scheme 14 is illustrated by Step A of Synthesis Example 6.

Scheme 14

<img file="MD4889B1_D0082.tif" />

As shown in Scheme 15, the compounds having Formula 1g (namely Formula 1 in which R¹is H, R⁴ și R⁵are H and Y²is S) can be prepared by reacting compounds of Formula la with at least two equivalents of a thionation reagent such as Lawesson's reagent, tetraphosphorus decasulfide or diphosphorus pentasulfide, in a solvent such as tetrahydrofuran or toluene. Typically, the reaction is carried out at temperatures from 0 to 115 °C. One of ordinary skill in the art knows that the use of less than two equivalents of thiation reagent can fumigate mixtures consisting of products of Formula 1 wherein Y¹is О and Y²is S, which can be separated by conventional methods such as chromatography and crystallization. Scheme 15

<img file="MD4889B1_D0083.tif" />

As shown in Scheme 16, compounds having Formula 1 h (namely Formula 1 in which R¹, R⁴, R⁵are Η, Y²is O and Y¹is NH) can be prepared by alkylating compounds of Formula with triethyloxonium tetrafluoroborate (Meerwein's reagent), followed by treatment of the resulting iminoether of Formula 19 with aqueous ammonia. The method of Scheme 16 is illustrated by Steps A and B of Synthesis Example 4.

Scheme 16

<img file="MD4889B1_D0084.tif" />

at 19 Ih

MD 4889 B1 2024.03.31

One skilled in the art will recognize that conversion of various functional groups to other functional groups can be accomplished to provide different compounds of Formula 1. For a valuable resource that illustrates the interconversion of functional groups in a simple and straightforward manner, see Larock, R. C., Comprehensive Organic Transformations: A Guide to Functional Group Preparations, 2nd Ed., WileyVCH, New York, 1999. For example, intermediate compounds for the preparation of compounds having Formula 1 may contain aromatic nitro groups, which can be reduced to amino groups, and then their conversion can be achieved by reactions well known in the art, such as the Sandmeyer reaction, in various halides, providing the compounds having Formula 1. The above reactions can also be carried out in many cases in an alternative order.

It should be considered that some reagents and reaction conditions described above for the preparation of compounds of Formula 1 may not be compatible with certain functionalities that characterize the intermediate compounds. In these cases, obtaining the desired products can be achieved by including protection/deprotection sequences or interconversion reactions between functional groups in the synthesis. The use and choice of protecting groups will be apparent to those skilled in the art of chemical synthesis (see, for example, Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). Those skilled in the art will recognize that in some cases, after introduction of a particular reagent in any individual scheme, additional routine synthetic steps that are not described in detail may be required to complete the synthesis of compounds of Formula 1. Those skilled in the art will also recognize that for the preparation of compounds of Formula 1 it may be necessary to carry out a combination of the steps illustrated in the schemes above in a different order than that described in the sequence shown.

Also, those skilled in the art will recognize that the compounds of Formula 1 and the intermediate compounds described herein may undergo various electrophilic, nucleophilic, radical, organometallic, oxidation and reduction reactions for addition of substituents or modification of existing substituents.

Without further detail, it is believed that one skilled in the art using the foregoing description can utilize the present invention to its full potential. Therefore, the following Examples are intended for illustrative purposes only and are not intended to limit the disclosure in any way. The steps in the following Examples illustrate a procedure for each step in a global synthetic transformation, and the starting material for each step need not necessarily have been prepared by a special preparative step whose procedure has been described in other Examples or Stages. Percentages are by weight, except for chromatography solvent mixtures or where otherwise indicated. Parts and percentages for chromatography solvent mixtures are by volume unless otherwise indicated. 1 H NMR spectra are expressed in ppm relative to tetramethylsilane in CDCk solutions unless otherwise stated; "s" stands for singlet, "d" stands for doublet, "t" stands for triplet, "q" stands for quartet, "m" stands for multiplet, and "br s" stands for broad singlet. spectra¹⁹F NMR are expressed in ppm relative to C'FC'l·, in CDCk unless otherwise stated. The enantiomeric ratio (ER) was determined by analysis using chiral high-performance liquid chromatography with a Chiralpak AD-RH column and eluting with a 50:50 isopropanol/water mixture at 40 °C and 0.3 mL / min.

EXAMPLE 1 OF SYNTHESIS

Preparation of 4-(3-chloro-4-fluorophenyl)-2-oxo-N-[2-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 74) Step A: Preparation of 2-(3-chloro-4-fluorophenyl) 1, 3-diethyl methylenepropanedioate

A mixture of 3-chloro-4-fluorobenzaldehyde (3 g, 18.9 mmol), diethyl malonate (3.16 mL, 20.8 mmol), piperidine (0.37 mL, 3.8 mmol), and toluene (40 mL) was heated at reflux for 18 h with continuous collection of water (with Dean-Stark dilution apparatus). The cooled reaction mixture was concentrated under reduced pressure and the residue was chromatographed on silica gel eluting with 0%...10% ethyl acetate in hexanes to afford the title compound as a yellow oil (5 g).

1H NMR δ 7.61 (m, 1H), 7.61 (m, 1H), 7.53 (m, 1H), 7.35 (m, 1H), 7.15 (m, 1H), 4, 33 (m, 4H), 1.33 (m, 6H).

Step B: Preparation of 1, 3-diethyl 2-[1-(3-chloro-4-fluorophenyl)-2-nitroethyl]propanedioate

A mixture of 1,3-diethyl 2-(3-chloro-4-fluorophenyl)methylenepropanedioate (namely the product of Step A, 5 g, 16.7 mmol), nitromethane (8.9 mL, 166 mmol) and a solution sodium methoxide methanol (25 wt%, 0.36 g, 1.67 mmol) in ethanol (60 mL) was stirred at 23 °C for 18 h. The reaction mixture was concentrated under reduced pressure to give a thick oil, which was diluted with 25% ethyl acetate in hexanes and filtered through a Celite® diatomite filter to remove insoluble particles. The filtrate was concentrated under reduced pressure to give the title compound as a yellow oil (5.3 g).

MD 4889 B1 2024.03.31

1H NMR δ 7.32 (m, 1H), 7.15 (m, 1H), 7.10 (m, 1H), 4.87 (m, 2H), 4.22 (m, 3H), 4, 07 (m, 2H), 3.76 (d, 1H), 1.27 (m, 3H), 1.12 (m, 3H).

Step C: Preparation of ethyl 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylate

A stirred mixture of 1,3-diethyl 2-[1-(3-chloro-4-fluorophenyl)-2-nitroethyl]propanedioate (namely the product of Step B, 5.3 g, 14.7 mmol), acetate tetrahydrate of nickel(II) (18.3 g, 73.4 mmol) and ethanol (120 mL) was cooled in an ice bath and treated with sodium borohydride (2.8 g, 73.4 mmol) in portions of 0.5 g added over 5 minutes. The resulting mixture was stirred at 26 °C for 18 h. Saturated ammonium chloride solution (120 mL) and ethyl acetate (120 mL) were then added, the mixture was stirred for 1 h and then filtered over a Celite® diatomite filter to remove insoluble particles. The filtrate layers were separated and the aqueous layer was extracted with ethyl acetate (2 x 100 mL). The combined organic extracts were washed with saturated ammonium chloride solution (100 mL), brine (100 mL), dried (MgSO4) and then concentrated under reduced pressure to afford the title compound as a yellow-orange solid. (4.73 g), which was used without purification.

1H NMR δ 7.31 (m, 1H), 7.12 (m, 2H), 6.93 (br s, 1H), 4.24 (m, 2H), 4.06 (m, 1H), 3, 82 (m, 1H), 3.49 (d, 1H), 3.39 (m, 1H), 1.29 (m, 3H).

Step D: Preparation of 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

A mixture of ethyl 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylate (namely the product of Step C, 4.73 g, 16.5 mmol) and aqueous sodium hydroxide (50% in wt, 1.98 g, 49.5 mmol) in ethanol (50 mL) was stirred at 26 °C for 18 h. The reaction mixture was then diluted with water (50 mL) and extracted with diethyl ether (2 x 50 mL). The aqueous phase was acidified with concentrated hydrochloric acid to pH 2 and extracted with dichloromethane (3 x 50 mL). The combined dichloromethane extracts were washed with brine, dried (MgSO 4) and concentrated under reduced pressure to afford the title compound as a white solid (2.37 g).

1H NMR (acetone-d6) δ 7.63 (m, 1H), 7.46 (m, 1H), 7.31 (m, 1H), 4.05 (m, 1H), 3.82 (m, 1H), 3.70 (d, 1H), 3.45 (m, 1H).

Step E: Preparation of 4-(3-chloro-4-fluorophenyl)-2-oxo-N-[2-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

A mixture of 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid (namely the product of Step D, 0.3 g, 1.17 mmol), triethylamine (0.49 mL, 3, 5 mmol) and 2-(trifluoromethyl)aniline (0.16 mL, 1.28 mmol) in dichloromethane (8 mL) was stirred at room temperature for 30 min, and then treated with propylphosphonic anhydride in ethyl acetate (50%, 1.26 g, 1.98 mmol). The resulting mixture was stirred at ambient temperature for 18 hours. The reaction mixture was then concentrated under reduced pressure and the residue was chromatographed on silica gel eluting with 0-30% ethyl acetate in hexanes to give a solid residue which on trituration with 1-chlorobutane provided the title product, a compound of the present invention in the form of a light pink solid product (0.2 g).

1H NMR δ 9.85 (s, 1H), 8.15 (m, 1H), 7.62 (m, 1H), 7.52 (m, 1H), 7.43 (m, 1H), 7, 27 (m, 1H), 7.22 (m, 1H), 7.14 (m, 1H), 6.93 (s, 1H), 4.15 (m, 1H), 3.82 (m, 1H), 3.55 (d, 1H), 3.44 (m, 1H).

EXAMPLE 2 OF SYNTHESIS

Preparation of 4-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide and 3-bromo-N-(2-fluorophenyl)-2-oxo-4phenyl-3-pyrrolidinecarboxamide (Compounds 92 and 93)

A mixture of 4-phenyl-2-oxo-N-(2-fluorophenyl)-3-pyrrolidinecarboxamide (prepared by the method of Example 1, 0.75 g, 2.5 mmol) in dichloromethane (25 mL) at room temperature of was treated with bromine (0.16 mL, 3.0 mmol), and the resulting mixture was stirred for 18 h. The reaction mixture was then concentrated under reduced pressure and the residue was chromatographed on silica gel, eluting with 0-2% methanol in dichloromethane, to give the faster eluting product, 4-bromo-N-(2-fluorophenyl)- 2-oxo-4-phenyl-3-pyrrolidinecarboxamide, a compound of the present invention, as a white solid (90 mg):

1H NMR δ 10.2 (br s, 1H), 8.00 (m, 1H), 7.28 (m, 5H), 7.02 (m, 3H), 6.45 (br s, 1H), 4.15 (d, 1H), 4.05 (m, 1H), 3.55 (d, 1H);

and the slower eluting product, 3-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide, a compound of the present invention, as a clear yellow oil (0, 31g):

1H NMR δ 9.55 (br s, 1H), 8.25 (t, 1H), 7.48 (d, 2H), 7.38 (m, 3H), 7.11 (m, 3H), 6, 85 (br s, 1H), 4.45 (m, 1H), 3.77 (m, 1H), 3.65 (m, 1H).

EXAMPLE 3 OF SYNTHESIS

Preparation of 4-(3, 4-difluorophenyl)-N-(2-fluorophenyl)-1-hydroxy-2-oxo-3-pyrrolidinecarboxamide (Compound

44)

MD 4889 B1 2024.03.31

Step A: Preparation of ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanoate

To a stirred solution of 2-fluoroaniline (10 g, 90.0 mmol) and triethylamine (9.1 g, 90.0 mmol) in dichloromethane (50 mL) at 0 °C was added dropwise over 10 min a solution of ethyl malonyl chloride (15.5 g, 90.0 mmol) in dichloromethane (30 mL). The resulting mixture was stirred at room temperature for 24 hours. The reaction mixture was then poured into water (100 mL) and the organic layer was separated, washed with water (50 mL) and brine (50 mL), dried (MgSO 4) and concentrated under reduced pressure to provide the compound of title as an amber oil (19.0 g).

1H NMR δ 9.46 (br s, 1H), 8.28 (m, 1H), 7.1 (m, 2H), 4.26 (m, 2H), 3.51 (s, 2H), 1, 32 (t, 3H).

Step B: Preparation of ethyl 3-(3,4-difluorophenyl)-2-[[(2-fluorophenyl)amino]carbonyl]-2-propenoate

A solution of ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanoate (namely the product of Step A, 20.27 g, 90.0 mmol), 3,4-difluorobenzaldehyde (16.62 g, 117 mmol), acetic acid (2.6 mL, 45 mmol) and piperidine (0.89 mL, 9.0 mmol) in toluene (150 mL) was heated at reflux for 10 h with continuous collection of water (with the Dean-Stark dilution). The reaction mixture was then cooled to room temperature and poured into water (100 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were washed with aqueous hydrochloric acid (1 N, 100 mL), dried (MgSO 4), and concentrated under reduced pressure to afford a solid residue. Recrystallization of the solid from diethyl ether (100 mL) afforded the title compound as a white solid (10.5 g).

1H NMR δ 8.26-8.48 (m, 1H), 8.15 (m, 1H), 7.74 (s, 1H), 7.51 (m, 1H), 7.35 (m, 1H), 7.11 (m, 4H), 4.35 (m, 2H), 1.36 (t, 3H).

Step C: Preparation of ethyl 3, 4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-3-(nitromethyl)benzenepropanoate

To a stirred suspension of ethyl 3-(3,4-difluorophenyl)-2-[[(2-fluorophenyl)amino]carbonyl]-2-propenoate (namely the product of Step B, 4.42 g, 12.7 mmol) and nitromethane (17 mL, 317.5 mmol) at -20 °C was added 1,1,3,3-tetramethylguanidine (0.288 mL, 2.3 mmol). The mixture was stirred at -20 °C for 30 min and then allowed to reach room temperature and stirred for an additional 2 h. The reaction mixture was diluted with dichloromethane (50 mL) and extracted with water (3 x 25 mL). The organic layer was dried (MgSO 4) and concentrated under reduced pressure to give a solid residue. The solid residue was chromatographed on silica gel, eluting with 0-100% ethyl acetate in hexanes, to provide the title compound as a white solid (4.42 g).

1H NMR δ 8.6 (br s, 1H), 8.00-8.30 (m, 3H), 7.23 (m, 4H), 5.41 (m, 1H), 4.6 (m, 1H), 4.35 (m, 2H), 3.77-4.00 (m, 2H), 1.45 (m, 3H).

Step D: Preparation of 4-(3, 4-difluorophenyl)-N-(2-fluorophenyl)-1-hydroxy-2-oxo-3-pyrrolidinecarboxamide

A mixture of ethyl 3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-3-(nitromethyl)benzenepropanoate (namely the product of Step C, 0.50 g, 1.22 mmol), palladium 5% on carbon (0.25 g) and ethyl methanol acetate (1:1 v/v, 10 mL) was stirred at room temperature for 30 min, then cooled to 0 °C and treated with ammonium formate (0.5g). The resulting mixture was stirred for 1 hour at room temperature. Additionally, 5% palladium on carbon (0.25 g) and ammonium formate (0.5 g) were added, and stirring at room temperature was continued for an additional 4 h. The reaction mixture was then filtered and the filtrate was concentrated under pressure to provide a residue which was suspended in water (10 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic extracts were dried (MgSO 4) and concentrated under reduced pressure to provide an oil which on recrystallization from dichloromethane provided the title product, a compound of the present invention, as a white solid (0.1 g).

1H NMR (DMSO-d6) δ 10.11 (br s, 2H), 8.00 (m, 1H), 7.71 (m, 1H), 7.42 (m, 1H), 7.33 (m, 3H), 7.1 (m, 1H), 4.25-3.61 (m, 4H).

EXAMPLE 4 OF SYNTHESIS

Preparation of 2-amino-4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-3H-pyrrole-3-carboxamide (Compound 95)

Step A: Preparation of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide

To a stirred mixture of ethyl 3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]3-(nitromethyl)benzenepropanoate (namely the product of Example 3, Step C, 3,346 g, 8, 16 mmol) and nickel(II) acetate tetrahydrate (10.15 g, 40.8 mmol) in ethanol (50 mL) at 0 °C, sodium borohydride (1.54 g, 40.8 mmol) was added portionwise), and the resulting mixture was stirred at room temperature for 24 hours. The reaction mixture was concentrated under reduced pressure, dissolved in ethyl acetate (100 mL) and washed successively with saturated ammonium chloride solution (50 mL), water (2 x

MD 4889 B1 2024.03.31 mL) and saturated sodium chloride (20 mL). The organic layer was dried (MgSO 4) and concentrated under reduced pressure to give a solid residue. The residue was chromatographed on silica gel, eluting with 0-100% ethyl acetate in hexanes to provide the title compound as a white solid (0.746 g).

1H NMR δ 9.67 (br s, 1H), 8.21 (m, 1H), 7.09 (m, 6H), 4.75 (br s, 1H), 4.21 (m, 1H), 3.82 (m, 1H), 3.52 (m, 1H), 3.43 (m, 1H).

Step B: Preparation of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-2-methoxy-3H-pyrrole-3-carboxamide

A mixture of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide (namely the product of Step A, 0.187 g, 0.56 mmol) and trimethyloxonium tetrafluoroborate (0.083 g, 0.56 mmol) in dichloromethane (5 mL) was stirred under nitrogen for 2 days. The reaction mixture was then treated with 1 N aqueous sodium hydroxide until basic (pH 10) and extracted with dichloromethane (3 x 5 mL). The organic layer was dried (MgSO 4) and concentrated under reduced pressure to give the title compound as a pale yellow oil (0.138 g).

1H NMR δ 9.7 (br s, 1H), 8.62 (m, 1H), 8.25 (s, 1H), 7.26 (m, 4H), 7.00 (m, 1H), 4, 26 (m, 2H), 4.00 (s, 3H), 3.42 (m, 2H).

Step C: Preparation of 2-amino-4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-3H-pyrrole-3-carboxamide

A mixture of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-2-methoxy-3H-pyrrole-3-carboxamide (namely the product of Step B, 0.10 g, 0.287 mmol) and aqueous ammonium hydroxide (50%, 0.5 mL) in ethanol (2 mL) was heated in the microwave for 10 min. The reaction mixture was then concentrated under reduced pressure and the residue was chromatographed on silica gel, eluting with 0-100% ethyl acetate/hexane, to obtain the title product, a compound of the present invention, as a solid (0, 016 g). 1H NMR δ 9.67 (br s, 1H), 8.21 (m, 1H), 7.27-7.01 (m, 6H), 6.50 (br s, 1H), 5.00 (br s, 1H), 4.26 (m, 1H), 3.82 (m, 1H), 3.55 (m, 1H), 3.43 (m, 1H). EXAMPLE 5 OF SYNTHESIS

Preparation of (3 R, 4 S)-N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 204) Step A: Preparation of 1-[(E)- 2-nitroethenyl]-3-(trifluoromethyl)benzene

To a stirred solution of 3-(trifluoromethyl)benzaldehyde (12.2 g, 70.1 mmol) in methanol (50 mL) was added nitromethane (4.34 g, 71.1 mmol). The mixture was cooled to 2 °C and sodium hydroxide (5.65 g, 70.6 mmol) was added as a 50% solution in 24.3 mL of water dropwise over 15 min. An exothermic reaction occurred and additional ice was added to keep the temperature below 10 °C while the mixture was stirred for an additional 1 h. The reaction mixture was poured into 75 mL (75 mmol) of 1 N hydrochloric acid, rinsing the flask with 10 mL of methanol/water. The quenched reaction mixture was transferred to a separatory funnel and extracted with 150 mL of toluene. The aqueous layer was separated and concentrated in vacuo to give 15.84 g of a yellow oil.

The thus obtained intermediate (15.84 g, 67.3 mmol) was mixed with 160 mL of dichloromethane. The solution was cooled to 3 °C and methanesulfonyl chloride (8.03 g, 71.1 mmol) was added by pipetting as a solution in 50 mL of dichloromethane. A solution of triethylamine (14.2 g, 140 mmol) in 50 mL of dichloromethane was then added dropwise over 50 min, and the resulting solution was stirred for 2 h. The reaction mixture was poured into 150 mL (150 mmol) of 1 N hydrochloric acid and transferred to a separatory funnel. The layers were separated and the organic layer was washed with 150 mL of water and then filtered. The organic layer was concentrated under reduced pressure and the crude solid was triturated with hexanes to obtain 12.09 g of yellow solid product.

1 H NMR (500 MHz) δ 7.54-7.66 (m, 2H) 7.69-7.84 (m, 3H) 7.96-8.08 (m, 1H).

Step B: Preparation of 1, 3-diethyl 2-[(1 S)-2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl]propanedioate

To a stirred mixture of 1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene (namely the product of Step A, 3 g, 13.8 mmol) and diethyl malonate (3,319 g, 20, 7 mmol) in toluene (1.5 mL) was added Ni(II) bis[(R, R)- N, N -dibenzylcyclohexane-1,2-diamine] bromide (prepared as described in J. Am. Chem Soc. 2005, 127, 9958-9959; 0.111 g, 0.1 mmol). The resulting solution was stirred at 55 °C for 16 h. The solution was diluted with dichloromethane (20 mL) and concentrated under reduced pressure on silica gel and purified by chromatography, eluting with a gradient of ethyl acetate in hexanes (between 0 and 50%) to provide 3.6 g of a colored oil light yellow. ER 94:6 (major elution at 26.5 min, minor elution at 20.3 min).

1H NMR (500 MHz) δ 7.54-7.60 (m, 1H), 7.43-7.48 (m, 2H), 7.51 (s, 1H), 4.83-5.00 (m, 2H), 4.17-4.35 (m, 3H), 3.98-4.06 (m, 2H), 3.77-3.85 (m, 1H), 1.20-1, 29 (m, 3H), 0.99-1.10 (m, 3H).¹⁹F NMR (471 MHz) δ -62.78 (s, 3F). ESI [M-1] 376, 3.

Step C: Preparation of ethyl (3 R, 4 S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylate

MD 4889 B1 2024.03.31

A stirred mixture of 1,3-diethyl 2-[(1 S)-2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl]propanedioate (namely the product of Step B, 3.24 g, 8.48 mmol), nickel(II) chloride hexahydrate (2.01 g, 8.48 mmol) and ethanol (60 mL) was cooled in an ice bath and treated with sodium borohydride (0.97 g, 25, 8 mmol) in 0.5 g fractions added over 5 min. The resulting mixture was stirred at 26 °C for 18 h. Saturated ammonium chloride solution (120 mL) and ethyl acetate (120 mL) were then added, the mixture was stirred for 1 h, and then filtered through a Celite® diatomite filter to remove insoluble particles. The filtrate layers were separated and the aqueous layer was extracted with ethyl acetate (2 x 100 mL). The combined organic extracts were washed with saturated ammonium chloride solution (100 mL), brine (100 mL), dried (MgSO4) and then concentrated under reduced pressure to afford the title compound as a thick yellow oil (2, 66 g), which was used without purification.

1H NMR (500 MHz) δ 7.38-7.62 (m, 4H), 6.50 (br s, 1H), 4.21-4.31 (m, 2H), 4.15-4.21 (m, 1H), 3.82-3.92 (m, 1H), 3.51-3.58 (m, 1H), 3.37-3.50 (m, 1H), 1.27-1, 34 (m, 3H).¹⁹F NMR (471 MHz) δ -62.70 (s, 3F). ESI; [M+1] = 302.0.

Step D: Preparation of (3 R, 4 S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid

A mixture of ethyl (3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylate (namely the product of Step C, 2.66 g, 8.8 mmol) and sodium hydroxide aq. (50 wt%, 2.12 g, 26.5 mmol) in ethanol (30 mL) was stirred at 26 °C for 18 h. The reaction mixture was then diluted with water (50 mL) and extracted with diethyl ether (2 x 50 mL). The aqueous phase was acidified with concentrated hydrochloric acid to pH 2 and extracted with dichloromethane (3 x 50 mL). The combined dichloromethane extracts were washed with brine, dried (MgSO 4) and concentrated under reduced pressure to afford the title compound as a white solid (2.05 g).

1H NMR (500 MHz, acetone-d6) δ 11.50 (br s, 1H), 7.70–7.89 (m, 2H), 7.56–7.68 (m, 2H), 7.45 (br s, 1H), 4.09-4.21 (m, 1H), 3.83-3.92 (m, 1H), 3.73-3.81 (m, 1H), 3.42- 3.55 (m, 1H).¹⁹F NMR (471 MHz, acetone-d₆) δ -63.03 (s, 3F). ESI; [M+1] = 274.0.

Step E: Preparation of (3 R, 4 S)-N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

A mixture of (3 R, 4 S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid (namely the product of Step D, 2.0 g, 7.32 mmol), triethylamine (3.06 mL, 21.96 mmol) and 2-fluoroaniline (0.85 mL, 8.78 mmol) in dichloromethane (50 mL) was stirred at room temperature for 30 min, and then treated with propylphosphonic anhydride in ethyl acetate (50%, 7.92 g, 12.44 mmol). The resulting mixture was stirred at ambient temperature for 18 hours. The reaction mixture was then concentrated under reduced pressure and the residue was chromatographed on silica gel eluting with 0-100% ethyl acetate in hexanes to give a solid residue which on trituration with 1-chlorobutane provided the title product, a compound of the present invention as a white solid product (1.9 g). ER 88:12 (major elution at 25.86 min, minor elution at 17.66 min). Specific rotation +74.71 at 23.4 °C at 589 nm, as a 1% solution (1 g/100 mL) in CHCl·,.

1H NMR (500 MHz, acetone-d6) δ 10.05 (br s, 1H), 8.21–8.35 (m, 1H), 7.77–7.91 (m, 2H), 7.58 -7.66 (m, 2H), 7.51 (br s, 1H), 7.02-7.22 (m, 3H), 4.18-4.30 (m, 1H), 3.94- 4.04 (m, 1H), 3.84-3.93 (m, 1H), 3.42-3.53 (m, 1H).¹⁹F NMR (471 MHz, acetone-d6) δ -62.93 (s, 3F), -131.13 - -131.02 (m, 1F). EXAMPLE 6 OF SYNTHESIS

Preparation of (3 R, 4 S)-N-(2-Fluorophenyl)-1-methyl-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 351)

Step A Preparation of (4 S)-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone

A mixture of (3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid (namely the product of Example 5, Step D, 1.5 g, 5.5 mmol) and acid Toluene-4-sulfonic acid (0.010 g, 0.055 mmol) in toluene (12 mL) was stirred at 90 °C overnight. The reaction mixture was then concentrated under reduced pressure to give a clear oil (1.29 g). The crude product was used without further purification.

1H NMR (500 MHz) δ 7.36-7.59 (m, 4H), 6.84 (br s, 1H), 3.70-3.88 (m, 2H), 3.35-3.50 (m, 1H), 2.72-2.87 (m, 1H), 2.44-2.58 (m, 1H).¹⁹F NMR (471 MHz) δ -62.66 (s, 3F).

Step B: Preparation of (4S)-1-methyl-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone

To a solution of (4S)-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone (namely the product of Step A, 1.29 g, 5.6 mmol) in N,N-dimethylformamide (7 mL) was added sodium hydride (60% dispersion in mineral oil, 0.25 g, 6.2 mmol), portionwise. The mixture was stirred for 10 min, and then iodo-methane (0.88 mL, 14.1 mmol) was added. The solution was stirred overnight at ambient temperature. The reaction mixture was diluted with water and extracted with diethyl ether (2 x 50 mL). The organic layer was washed with water, brine and then dried (MgSO 4), filtered and concentrated under reduced pressure. The crude residue was chromatographed on silica gel eluting with 0-20% ethyl acetate in dichloromethane to provide a light brown oil (0.775 g).

MD 4889 B1 2024.03.31

1H NMR (500 MHz) δ 7.38-7.57 (m, 4H), 3.75-3.83 (m, 1H), 3.59-3.70 (m, 1H), 3.38- 3.45 (m, 1H), 2.90-2.94 (m, 3H), 2.80-2.89 (m, 1H), 2.48-2.58 (m, 1H).¹⁹F NMR (471 MHz) δ -62.67 (s, 3F).

Step C Preparation of (3 R, 4 S)-N-(2-fluorophenyl)-1-methyl-2-oxo-4-[3-(trifluoromethyl)phenyl]-3pyrrolidinecarboxamide

A solution of (4 S)-1-methyl-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone (namely the product of Step B, 0.350 g, 1.44 mmol) in tetrahydrofuran (5 mL) of was cooled to -78 °C. To this mixture was added dropwise lithium bis(trimethylsilyl)amide (1.6 mL, 1.6 mmol as a solution in 1 M tetrahydrofuran), and the resulting solution was stirred for 30 min. Then 1-fluoro-2-isocyanatebenzene (0.17 mL, 1.44 mmol) was added dropwise, and the solution was stirred for 2 h at -78 °C. The reaction mixture was quenched with saturated aqueous ammonium chloride (10 mL), warmed to ambient temperature, and the aqueous layer was extracted with ethyl acetate (3 x 25 mL). The organic layers were combined, washed with brine and then dried (MgSO 4), filtered and concentrated under reduced pressure on silica gel. The crude residue was chromatographed on silica gel eluting with 0 to 40% ethyl acetate in hexanes to afford a pale pink solid (0.223 g). 1H NMR (500 MHz) δ 9.93 (br s, 1H), 8.15-8.27 (m, 1H), 7.38-7.65 (m, 4H), 6.93-7.15 (m, 3H), 4.10-4.23 (m, 1H), 3.72-3.88 (m, 1H), 3.56-3.68 (m, 1H), 3.39-3, 53 (m, 1H), 2.90-3.06 (m, 3H).¹⁹F NMR (471 MHz) δ -62.55 (s, 3F), -129.83 - -129.50 (m, 1F). ESI; [M+1] = 381.0.

EXAMPLE 7 OF SYNTHESIS

Preparation of 1,3-diethyl 2-[(1 S)-1-(3,4-difluorophenyl)-2-nitro-ethyl]propanedioate (intermediate for the preparation of compound 103)

Step A: Preparation of 1,3-diethyl 2-[(1 S)-1-(3,4-difluorophenyl)-2-nitro-ethyl]propanedioate

To a stirred mixture of 1-[(E)-2-nitroethenyl]-3,4-difluorobenzene (prepared as generally described in WO2008/39882 A1, 1.67 g, 9.0 mmol) and malonate of diethyl (1.73 g,

10.8 mmol) in toluene (10 mL) was added Ni(II) bis[(R,R)-N,N-dibenzylcyclohexane-1,2diamine bromide (prepared as described in J. Am. Chem. Soc. 2005, 127, 9958-9959; 0.072 g,

0.1 mmol). The resulting solution was stirred at ambient temperature for 72 hours. The solution was diluted with dichloromethane (20 mL) and concentrated under reduced pressure on silica gel and purified by chromatography, eluting with a gradient of ethyl acetate in hexanes (between 0 and 50%) to provide 2.18 g of waxy solid product light yellow. ER 96:4 (major elution at 37.05 min, minor elution at 27.09 min).

1H NMR (500 MHz) δ 7.06-7.16 (m, 2H), 6.95-7.03 (m, 1H), 4.73-4.94 (m, 2H), 4.16- 4.29 (m, 3H), 4.01-4.10 (m, 2H), 3.71-3.79 (m, 1H), 1.22-1.30 (m, 3H), 1, 07-1, 15 (m, 3H).¹⁹F NMR (471 MHz) δ -137.66 - -137.47 (m, 1F) -136.10 - -135.87 (m, 1F). ESI [M+1]; 346, 4.

By the procedures described herein, in conjunction with methods known in the art, the following compounds of Tables 1 through 6800 may be prepared. The following abbreviations are used in the Tables below: t means tertiary, \ means secondary, n means normal, i means iso, c means cyclo, Me means methyl, Et means ethyl, Pr means propyl, Bu means butyl, i-Pr means isopropyl, c-Pr cyclopropyl, t-Bu means tertiary butyl, c-Bu means cyclobutyl, Ph means phenyl, OMe means methoxy, OEt means ethoxy, SMe means methylthio, NHMe means methylamino, CN means cyano, NO2 means nitro, TMS means trimethylsilyl, SOMe means methylsulfinyl, C2F5 means CF2CF3 and SO2Me means methylsulfonyl.

Table 1

<img file="MD4889B1_D0085.tif" />

h

<td colspan="3">Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F); and Q¹It is</td>

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-Cl)</td><td>Ph(3-Et)</td><td></td>

<td>Ph(3-F)</td><td>Ph(3-t-Bu)</td><td>Ph(3-CH=CH2)</td>

<td>Ph(3-Br)</td><td>Ph(3- i -Pr)</td><td>Ph(3-CF3)</td>

<td>Ph(3-Me)</td><td>Ph(3-c-Pr)</td><td>Ph(3-CH2CF3)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-CHF2)</td><td>1H-pyrazol-4-yl(1-Me)</td><td></td>

<td>Ph(3-CH2F)</td><td>1H-pyrazol-4-yl(1-CH2CF3)</td><td>Ph(4-NHCOMe)</td>

<td>Ph(3-OCF3)</td><td>1H-imidazol-2-yl(1-Me)</td><td></td>

<td>Ph(3-OCH2F)</td><td>1H-imidazol-2-yl(1-CH2CF3)</td><td>Ph(4-CN)</td>

<td>Ph(3-SCF3)</td><td>1H-imidazol-2-yl(1-Me, 5-Cl)</td><td>Ph(4-NO2)</td>

<td>Ph(3-SMe)</td><td>1H-imidazol-2-yl(1-Me, 5-F)</td><td></td>

<td>Ph(3-SOMe)</td><td>2-thienyl</td><td>Ph(4-COMe)</td>

<td>3-SO2Me</td><td>2-thienyl(4-F)</td><td>Ph(4-OCOMe)</td>

<td>Ph(3-OSO2Me)</td><td>2-thienyl(4-Cl)</td><td>Ph(4-CO2Me)</td>

<td>Ph(3-CCH)</td><td>2-thienyl(4-CF3)</td><td></td>

<td>Ph(3-OMe)</td><td>2-thienyl(5-F)</td><td>Ph(4-TMS)</td>

<td>Ph(3-OEt)</td><td>2-thienyl(5-Cl) 2-thienyl(5-CF3)</td><td>Ph(4-SF5)</td>

<td>Ph(3-NHCOMe)</td><td>Ph(4-Cl)</td><td></td>

<td></td><td>Ph(4-F)</td><td></td>

<td>Ph(3-CN)</td><td>Ph(4-Br)</td><td></td>

<td>Ph(3-NO2)</td><td>Ph(4-Me) Ph(4-Et)</td><td></td>

<td>Ph(3-COMe)</td><td>Ph(4-1-Bu)</td><td>3-pyridinyl(5-CF3)</td>

<td>Ph(3-OCOMe)</td><td>Ph(4- i -Pr)</td><td>3-pyridinyl(5-Cl)</td>

<td>Ph(3-CO2Me)</td><td>Ph(4- c -Pr)</td><td>3-pyridinyl(5-F) 3-pyridinyl(5-OCF3)</td>

<td>Ph(3-TMS)</td><td>Ph(4-CH=CH2)</td><td>3-pyridinyl(5-Me)</td>

<td>Ph(3-SF5)</td><td>Ph(4-CF3)</td><td>3-pyridinyl(5-Br)</td>

<td></td><td>Ph(4-CH2CF3)</td><td>3-pyridinyl</td>

<td></td><td>Ph(4-CHF2)</td><td>1H-pyrazol-3-yl(1-Me)</td>

<td></td><td>Ph(4-CH2F)</td><td>1H-pyrazol-3-yl(1-CH2CF3)</td>

<td></td><td>Ph(4-OCF3)</td><td>1H-pyrazol-3-yl(1-Me,4-F)</td>

<td></td><td>Ph(4-OCH2F)</td><td>1H-pyrazol-3-yl(1-Me,4-Cl)</td>

<td></td><td>Ph(4-SCF3)</td><td>1H-imidazol-5-yl(1-Me)</td>

<td>4-pyridinyl(2-CF3)</td><td>Ph(4-SMe)</td><td>1H-imidazol-5-yl(1-CH2CF3)</td>

<td>4-pyridinyl(2-Cl)</td><td>Ph(4-SOMe)</td><td>1H-imidazol-4-yl(1-Me)</td>

<td>4-pyridinyl(2-F)</td><td>Ph(4-SO2Me)</td><td>1H-imidazol-4-yl(1-CH2CF3)</td>

<td>4-pyridinyl(2-OCF3)</td><td>Ph(4-OSO2Me)</td><td>3-thienyl</td>

<td>4-pyridinyl(2-Me)</td><td>Ph(4-CCH)</td><td>3-thienyl(5-F)</td>

<td>4-pyridinyl(2-Br)</td><td>Ph(4-OMe)</td><td>3-thienyl(5-Cl)</td>

<td>4-pyridinyl</td><td>Ph(4-OEt)</td><td>3-thienyl(5-CF3)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3, 4-di-Cl)</td><td>Ph(3-Br, 4-TMS)</td><td>Ph(3- c -Pr, 4-SO2Me)</td>

<td>Ph(3-Cl, 4-F)</td><td>Ph(3-Br, 4-CN)</td><td>Ph(3- c -Pr, 4-TMS)</td>

<td>Ph(3-Cl, 4-Br)</td><td>Ph(3-Me, 4-Cl)</td><td>Ph(3- c -Pr, 4-CN)</td>

<td>Ph(3-Cl, 4-Me)</td><td>Ph(3-Me, 4-F)</td><td>Ph(3-CF3,4-Cl)</td>

<td>Ph(3-Cl, 4-1-Bu)</td><td>Ph(3-Me, 4-Br)</td><td>Ph(3-CF3,4-F)</td>

<td>Ph(3-Cl, 4- c -Pr)</td><td>Ph(3, 4-di-Me)</td><td>Ph(3-CF3,4-Br)</td>

<td>Ph(3-Cl, 4-CF3)</td><td>Ph(3-Me, 4-t-Bu)</td><td>Ph(3-CF3,4-Me)</td>

<td>Ph(3-Cl, 4-CHF₂)</td><td>Ph(3-Me, 4- c -Pr)</td><td>Ph(3-CF3,4-1-Bu)</td>

<td>Ph(3-Cl, 4-OCF3)</td><td>Ph(3-Me, 4-CF3)</td><td>Ph(3-CF3, 4-c-Pr)</td>

<td>Ph(3-Cl, 4-OCHF2)</td><td>Ph(3-Me, 4-OCF3)</td><td>Ph(3, 4-di-CF3)</td>

<td>Ph(3-Cl, 4-SO2Me)</td><td>Ph(3-Me, 4-OCHF2)</td><td>Ph(3-CF3, 4-CHF2)</td>

<td>Ph(3-Cl, 4-TMS)</td><td>Ph(3-Me, 4-SO2Me)</td><td>Ph(3-CF3, 4-OCF3)</td>

<td>Ph(3-Cl, 4-CN)</td><td>Ph(3-Me, 4-TMS)</td><td>Ph(3-CF3, 4-OCHF2)</td>

<td>Ph(3-F, 4-Cl)</td><td>Ph(3-Me, 4-CN)</td><td>Ph(3-CF3, 4-SO2Me)</td>

<td>Ph(3, 4-di-F)*</td><td>Ph(3-1-Bu, 4-Cl)</td><td>Ph(3-CF3,4-TMS)</td>

<td>Ph(3-F, 4-Br)</td><td>Ph(3-1-Bu, 4-F)</td><td>Ph(3-CF3,4-CN)</td>

<td>Ph(3-F, 4-Me)</td><td>Ph(3-1-Bu, 4-Br)</td><td>Ph(3-OCF3, 4-Cl)</td>

<td>Ph(3-F, 4-1-Bu)</td><td>Ph(3-1-Bu, 4-Me)</td><td>Ph(3-OCF3, 4-F)</td>

<td>Ph(3-F, 4- c -Pr)</td><td>Ph(3, 4-di-t-Bu)</td><td>Ph(3-OCF3, 4-Br)</td>

<td>Ph(3-F, 4-CF3)</td><td>Ph(3-1-Bu, 4- c -Pr)</td><td>Ph(3-OCF3, 4-Me)</td>

<td>Ph(3-F, 4-CHF2)</td><td>Ph(3-1-Bu, 4-CF3)</td><td>Ph(3-OCF3,4-1-Bu)</td>

<td>Ph(3-F, 4-OCF3)</td><td>Ph(3-1-Bu, 4-CHF2)</td><td>Ph(3-OCF3, 4- c -Pr)</td>

<td>Ph(3-F,4-OCHF2)</td><td>Ph(3-1-Bu, 4-OCF3)</td><td>Ph(3-OCF3-4-CF3)</td>

<td>Ph(3-F, 4-SO2Me)</td><td>Ph(3-1-Bu, 4-OCHF2)</td><td>Ph(3-OCF3, 4-CHF2)</td>

<td>Ph(3-F, 4-TMS)</td><td>Ph(3-1-Bu, 4-SO2Me)</td><td>Ph(3, 4-di-OCF3)</td>

<td>Ph(3-F, 4-CN)</td><td>Ph(3-1-Bu, 4-TMS)</td><td>Ph(3-OCF3, 4-OCHF2)</td>

<td>Ph(3-F, 4-SF5)</td><td>Ph(3-1-Bu, 4-CN)</td><td>Ph(3-OCF3, 4-SO2Me)</td>

<td>Ph(3-Br, 4-Cl)</td><td>Ph(3- c -Pr, 4-Cl)</td><td>Ph(3-OCF3, 4-TMS)</td>

<td>Ph(3-Br, 4-F)</td><td>Ph(3- c -Pr, 4-F)</td><td>Ph(3-OCF3, 4-CN)</td>

<td>Ph(3,4-di-Br)</td><td>Ph(3- c -Pr, 4-Br)</td><td>Ph(3-SO2Me, 4-Cl)</td>

<td>Ph(3-Br, 4-Me)</td><td>Ph(3- c -Pr, 4-Me)</td><td>Ph(3-SO2Me, 4-F)</td>

<td>Ph(3-Br, 4- c -Pr)</td><td>Ph(3-c-Pr, 4-1-Bu)</td><td>Ph(3-SO2Me, 4-Br)</td>

<td>Ph(3-Br, 4-CF3)</td><td>Ph(3, 4-di-c-Pr)</td><td>Ph(3-SO2Me, 4-Me)</td>

<td>Ph(3-Br, 4-CHF2)</td><td>Ph(3- c -Pr, 4-CF3)</td><td>Ph(3-SO2Me, 4-1-Bu)</td>

<td>Ph(3-Br, 4-OCF3)</td><td>Ph(3- c -Pr, 4-CHF2)</td><td>Ph(3-SO2Me, 4- c -Pr)</td>

<td>Ph(3-Br, 4-OCHF2)</td><td>Ph(3- c -Pr, 4-OCF3)</td><td>Ph(3-SO2Me, 4-CF3)</td>

<td>Ph(3-Br, 4-SO2Me)</td><td>Ph(3- c -Pr, 4-OCHF2)</td><td>Ph(3-SO2Me, 4-CHF2)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-SO2Me, 4-OCF3)</td><td>Ph(2-F, 3-Cl, 4- c -Pr)</td><td>Ph(2-F, 3-Me, 4-Me)</td>

<td>Ph(3-SO2Me, 4-OCHF2)</td><td>Ph(2-F, 3-Cl, 4-CF3)</td><td>Ph(2-F, 3-Me, 4-t-Bu)</td>

<td>Ph(3, 4-di-SO2Me)</td><td>Ph(2-F, 3-Cl, 4-CHF2)</td><td>Ph(2-F, 3-Me, 4-CF3)</td>

<td>Ph(3-SO2Me, 4-TMS)</td><td>Ph(2-F, 3-Cl, 4-OCF3)</td><td>Ph(2-F, 3-Me, 4-CHF2)</td>

<td>Ph(3-SO2Me, 4-CN)</td><td>Ph(2-F, 3-Cl, 4-OCHF2)</td><td>Ph(2-F, 3-Me, 4-OCF3)</td>

<td>Ph(3-CHF2, 4-Cl)</td><td>Ph(2-F, 3-Cl, 4-SO2Me)</td><td>Ph(2-F, 3-Me, 4-OCHF2)</td>

<td>Ph(3-CHF2, 4-F)</td><td>Ph(2-F, 3-Cl, 4-TMS)</td><td>Ph(2-F, 3-Me, 4-SO2Me)</td>

<td>Ph(3-CHF2, 4-Br)</td><td>Ph(2-F, 3-Cl, 4-CN)</td><td>Ph(2-F, 3-Me, 4-TMS)</td>

<td>Ph(3-CHF2, 4-Me)</td><td>Ph(2-F, 3-F, 4-Cl)</td><td>Ph(2-F, 3-Me, 4-CN)</td>

<td>Ph(3-CHF2, 4-1-Bu)</td><td>Ph(2-F, 3-F, 4-F)</td><td>Ph(2-F, 3-1-Bu, 4-Cl)</td>

<td>Ph(3-CHF2, 4- c -Pr)</td><td>Ph(2-F, 3-F, 4-Br)</td><td>Ph(2-F, 3-1-Bu, 4-F)</td>

<td>Ph(3-CHF2, 4-CF3)</td><td>Ph(2-F, 3-F, 4-Me)</td><td>Ph(2-F, 3-1-Bu, 4-Br)</td>

<td>Ph(3-CHF2, 4-CHF2)</td><td>Ph(2-F, 3-F, 4-1-Bu)</td><td>Ph(2-F, 3-1-Bu, 4-Me)</td>

<td>Ph(3-CHF2, 4-OCF3)</td><td>Ph(2-F, 3-F, 4- c -Pr)</td><td>Ph(2-F, 3-1-Bu, 4-1-Bu)</td>

<td>Ph(3-CHF2, 4-OCHF2)</td><td>Ph(2-F, 3-F, 4-CF3)</td><td>Ph(2-F, 3-1-Bu, 4- c -Pr)</td>

<td>Ph(3-CHF2, 4-SO2Me)</td><td>Ph(2-F, 3-F, 4-CHF2)</td><td>Ph(2-F, 3-1-Bu, 4-CF3)</td>

<td>Ph(3-CHF2, 4-TMS)</td><td>Ph(2-F, 3-F, 4-OCF3)</td><td>Ph(2-F, 3-1-Bu, 4-CHF2)</td>

<td>Ph(3-CHF2, 4-CN)</td><td>Ph(2-F, 3-F, 4-OCHF2)</td><td>Ph(2-F, 3-1-Bu, 4-OCF3)</td>

<td>Ph(3-CN,4-Cl)</td><td>Ph(2-F, 3-F, 4-SO2Me)</td><td>Ph(2-F, 3-1-Bu, 4-OCHF2)</td>

<td>Ph(3-CN,4-F)</td><td>Ph(2-F, 3-F, 4-TMS)</td><td>Ph(2-F, 3-1-Bu, 4-SO2Me)</td>

<td>Ph(3-CN,4-Br)</td><td>Ph(2-F, 3-F, 4-CN)</td><td>Ph(2-F, 3-1-Bu, 4-TMS)</td>

<td>Ph(3-CN,4-Me)</td><td>Ph(2-F, 3-Br, 4-Cl)</td><td>Ph(2-F, 3-1-Bu, 4-CN)</td>

<td>Ph(3-CN, 4-1-Bu)</td><td>Ph(2-F, 3-Br, 4-F)</td><td>Ph(2-F, 3- c -Pr, 4-Cl)</td>

<td>Ph(3-CN, 4- c -Pr)</td><td>Ph(2-F, 3-Br, 4-Br)</td><td>Ph(2-F, 3- c -Pr, 4-F)</td>

<td>Ph(3-CN, 4-CF3)</td><td>Ph(2-F, 3-Br, 4-Me)</td><td>Ph(2-F, 3- c -Pr, 4-Br)</td>

<td>Ph(3-CN, 4-CHF2)</td><td>Ph(2-F, 3-Br, 4-1-Bu)</td><td>Ph(2-F, 3- c -Pr, 4-Me)</td>

<td>Ph(3-CN, 4-OCF3)</td><td>Ph(2-F, 3-Br, 4- c -Pr)</td><td>Ph(2-F, 3- c -Pr, 4-1-Bu)</td>

<td>Ph(3-CN, 4-OCHF2)</td><td>Ph(2-F, 3-Br, 4-CF3)</td><td>Ph(2-F, 3, 4-di-c-Pr)</td>

<td>Ph(3-CN, 4-SO2Me)</td><td>Ph(2-F, 3-Br, 4-CHF2)</td><td>Ph(2-F, 3- c -Pr, 4-CF3)</td>

<td>Ph(3-CN, 4-TMS)</td><td>Ph(2-F, 3-Br, 4-OCF3)</td><td>Ph(2-F, 3- c -Pr, 4-CHF2</td>

<td>Ph(3,4-di-CN)</td><td>Ph(2-F, 3-Br, 4-OCHF2)</td><td>Ph(2-F, 3- c -Pr, 4-OCF3)</td>

<td>Ph(3-SF5,4-F)</td><td>Ph(2-F, 3-Br, 4-SO2Me)</td><td>Ph(2-F, 3- c -Pr, 4-OCHF2)</td>

<td>Ph(2-F, 3-Cl, 4-Cl)</td><td>Ph(2-F, 3-Br, 4-TMS)</td><td>Ph(2-F, 3- c -Pr, 4-SO2Me)</td>

<td>Ph(2-F, 3-Cl, 4-F)</td><td>Ph(2-F, 3-Br, 4-CN)</td><td>Ph(2-F, 3- c -Pr, 4-TMS)</td>

<td>Ph(2-F, 3-Cl, 4-Br)</td><td>Ph(2-F, 3-Me, 4-Cl)</td><td>Ph(2-F, 3- c -Pr, 4-CN)</td>

<td>Ph(2-F, 3-Cl, 4-Me)</td><td>Ph(2-F, 3-Me, 4-F)</td><td>Ph(2-F, 3-CF3, 4-Cl)</td>

<td>Ph(2-F, 3-Cl, 4-1-Bu)</td><td>Ph(2-F, 3-Me, 4-Br)</td><td>Ph(2-F, 3-CF3, 4-F)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-CF3, 4-Br)</td><td>Ph(2-F, 3-CHF2, 4-Cl)</td><td>Ph(2-F,4-TMS)</td>

<td>Ph(2-F, 3-CF3, 4-Me)</td><td>Ph(2-F, 3-CHF2, 4-F)</td><td>Ph(2-F, 4-CN)</td>

<td>Ph(2-F, 3-CF3, 4-1-Bu)</td><td>Ph(2-F, 3-CHF2, 4-Br)</td><td>Ph(2-F, 3-Cl)</td>

<td>Ph(2-F, 3-CF3, 4-c -Pr)</td><td>Ph(2-F, 3-CHF2, 4-Me)</td><td>Ph(2-F, 3-F)</td>

<td>Ph(2-F, 3-CF3, 4-CF3)</td><td>Ph(2-F, 3-CHF2, 4-t-Bu)</td><td>Ph(2-F, 3-Br)</td>

<td>Ph(2-F, 3-CF3, 4-CHF2)</td><td>Ph(2-F, 3-CHF2, 4- c -Pr)</td><td>Ph(2-F, 3-Me)</td>

<td>Ph(2-F, 3-CF3, 4-OCF3)</td><td>Ph(2-F, 3-CHF2, 4-CF3)</td><td>Ph(2-F, 3-1-Bu)</td>

<td>Ph(2-F, 3-CF3, 4-OCHF2)</td><td>Ph(2-F, 3-CHF2, 4-CHF2)</td><td>Ph(2-F, 3- c -Pr)</td>

<td>Ph(2-F, 3-CF3, 4-SO2Me)</td><td>Ph(2-F, 3-CHF2, 4-OCF3)</td><td>Ph(2-F, 3-CF3)</td>

<td>Ph(2-F, 3-CF3, 4-TMS)</td><td>Ph(2-F, 3-CHF2, 4-OCHF2)</td><td>Ph(2-F, 3-CHF2)</td>

<td>Ph(2-F, 3-CF3, 4-CN)</td><td>Ph(2-F, 3-CHF2, 4-SO2Me)</td><td>Ph(2-F, 3-OCF3)</td>

<td>Ph(2-F, 3-OCF3, 4-Cl)</td><td>Ph(2-F, 3-CHF2, 4-TMS)</td><td>Ph(2-F, 3-OCHF2)</td>

<td>Ph(2-F, 3-OCF3, 4-F)</td><td>Ph(2-F, 3-CHF2, 4-CN)</td><td>Ph(2-F, 3-SO2Me)</td>

<td>Ph(2-F, 3-OCF3, 4-Br)</td><td>Ph(2-F, 3-CN, 4-Cl)</td><td>Ph(2-F,3-TMS)</td>

<td>Ph(2-F, 3-OCF3, 4-Me)</td><td>Ph(2-F, 3-CN, 4-F)</td><td>Ph(2-F, 3-CN)</td>

<td>Ph(2-F, 3-OCF3, 4-1-Bu)</td><td>Ph(2-F, 3-CN, 4-Br)</td><td>Ph(2-Cl)</td>

<td>Ph(2-F, 3-OCF3, 4- c -Pr)</td><td>Ph(2-F, 3-CN, 4-Me)</td><td>Ph(2-F)</td>

<td>Ph(2-F, 3-OCF3, 4-CF3)</td><td>Ph(2-F, 3-CN, 4-t-Bu)</td><td>Ph(2-Br)</td>

<td>Ph(2-F, 3-OCF3, 4-CHF2)</td><td>Ph(2-F, 3-CN, 4- c -Pr)</td><td>Ph(2-I)</td>

<td>Ph(2-F, 3-OCF3, 4-OCF3)</td><td>Ph(2-F, 3-CN, 4-CF3)</td><td>Ph(2-Me)</td>

<td>Ph(2-F, 3-OCF3, 4-OCHF2)</td><td>Ph(2-F, 3-CN, 4-CHF2)</td><td>Ph(2-Et)</td>

<td>Ph(2-F, 3-OCF3, 4-SO2Me)</td><td>Ph(2-F, 3-CN, 4-OCF3)</td><td>Ph(2-n-Pr)</td>

<td>Ph(2-F, 3-OCF3, 4-TMS)</td><td>Ph(2-F, 3-CN, 4-OCHF2)</td><td>Ph(2-1-Bu)</td>

<td>Ph(2-F, 3-OCF3, 4-CN)</td><td>Ph(2-F, 3-CN, 4-SO2Me)</td><td>Ph(2- i -Pr)</td>

<td>Ph(2-F, 3-SO2Me, 4-Cl)</td><td>Ph(2-F, 3-CN, 4-TMS)</td><td>Ph(2- c -Pr)</td>

<td>Ph(2-F, 3-SO2Me, 4-F)</td><td>Ph(2-F, 3-CN, 4-CN)</td><td></td>

<td>Ph(2-F, 3-SO2Me, 4-Br)</td><td>Ph(2-F, 4-Cl)</td><td>Ph(2-CH=CH2)</td>

<td>Ph(2-F, 3-SO2Me, 4-Me)</td><td>Ph(2-F, 4-F)</td><td>Ph(2-CF3)</td>

<td>Ph(2-F, 3-SO2Me, 4-t-Bu)</td><td>Ph(2-F, 4-Br)</td><td>Ph(2-CH2CF3)</td>

<td>Ph(2-F, 3-SO2Me, 4- c -Pr)</td><td>Ph(2-F, 4-Me)</td><td>Ph(2-CF2H)</td>

<td>Ph(2-F, 3-SO2Me, 4-CF3)</td><td>Ph(2-F, 4-1-Bu)</td><td>Ph(2-CHF)</td>

<td>Ph(2-F, 3-SO2Me, 4-CHF2)</td><td>Ph(2-F, 4- c -Pr)</td><td>Ph(2-OCF3)</td>

<td>Ph(2-F, 3-SO2Me, 4-OCF3)</td><td>Ph(2-F, 4-CF3)</td><td>Ph(2-OCHF)</td>

<td>Ph(2-F, 3-SO2Me, 4-OCHF2)</td><td>Ph(2-F, 4-CHF2)</td><td>Ph(2-OCF2H)</td>

<td>Ph(2-F,3,4-di-SO2Me)</td><td>Ph(2-F, 4-OCF3)</td><td>Ph(2-SCF3)</td>

<td>Ph(2-F, 3-SO2Me, 4-TMS)</td><td>Ph(2-F, 4-OCHF2)</td><td>Ph(2-SMe)</td>

<td>Ph(2-F, 3-SO2Me, 4-CN)</td><td>Ph(2-F, 4-SO2Me)</td><td>Ph(2-SOMe)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-SO2Me)</td><td>Ph(2-CH=CF2)</td><td>Ph(3-CH=CF2)</td>

<td>Ph(2-OSO2Me)</td><td>Ph(2-CH=CCl2)</td><td>Ph(3-CH=CCl2)</td>

<td>Ph(2-CCH)</td><td>Ph(2-CH=CBr2)</td><td>Ph(3-CH=CBr2)</td>

<td>Ph(2-OMe)</td><td>Ph(2-OCH=CH2)</td><td>Ph(3-OCH=CH2)</td>

<td>Ph(2-OEt)</td><td>Ph(2-OCH=CF2)</td><td>Ph(3-OCH=CF2)</td>

<td></td><td>Ph(2-OCH=CCl2)</td><td>Ph(3-OCH=CCl2)</td>

<td>Ph(2-NHCOMe)</td><td>Ph(2-OCH=CBr2)</td><td>Ph(3-OCH=CBr2)</td>

<td></td><td>Ph(2-CH2CH=CH2)</td><td>Ph(3-CH2CH=CH2)</td>

<td>Ph(2-CN)</td><td>Ph(2-CH2CH=CF2)</td><td>Ph(3-CH2CH=CF2)</td>

<td>Ph(2-NO2)</td><td>Ph(2-CH2CH=CCl2)</td><td>Ph(3-CH2CH=CCl2)</td>

<td></td><td>Ph(2-CH2CH=CBr2)</td><td>Ph(3-CH2CH=CBr2)</td>

<td>Ph(2-COMe)</td><td>Ph(2-OCH2CH=CH2)</td><td>Ph(3-OCH2CH=CH2)</td>

<td>Ph(2-OCOMe)</td><td>Ph(2-OCH2CH=CF2)</td><td>Ph(3-OCH2CH=CF2)</td>

<td>Ph(2-CO2Me)</td><td>Ph(2-OCH2CH=CCl2)</td><td>Ph(3-OCH2CH=CCl2)</td>

<td>Ph(2-OCO2Me)</td><td>Ph(2-OCH2CH=CBr2)</td><td>Ph(3-OCH2CH=CBr2)</td>

<td>Ph(2-TMS)</td><td>Ph(2-SCF2H)</td><td>Ph(3-SCF2H)</td>

<td></td><td>Ph(2-SCF2CF2H)</td><td>Ph(3-SCF2CF2H)</td>

<td></td><td>Ph(3-I)</td><td>Ph(2-Cl, 3-Cl)</td>

<td></td><td>Ph(3-n-Pr)</td><td>Ph(2-Cl, 3-F)</td>

<td></td><td>Ph(3-CF2H)</td><td>Ph(2-Cl, 3-Br)</td>

<td></td><td>Ph(3-OCF2H)</td><td>Ph(2-Cl, 3-I)</td>

<td></td><td>Ph(3-SO2Me)</td><td>Ph(2-Cl, 3-Me)</td>

<td>Ph(2-C2F5)</td><td>Ph(3-C2F5)</td><td>Ph(2-Cl, 3-Et)</td>

<td>Ph(2-CF2CF2H)</td><td>Ph(3-CF2CF2H)</td><td>Ph(2-Cl, 3-n-Pr)</td>

<td>Ph(2-OCF2CF2H)</td><td>Ph(3-OCF2CF2H)</td><td>Ph(2-Cl, 3-1-Bu)</td>

<td>Ph(2-OC2F5)</td><td>Ph(3-OC2F5)</td><td>Ph(2-Cl, 3- i -Pr)</td>

<td>Ph(2-OCH2CF3)</td><td>Ph(3-OCH2CF3)</td><td>Ph(2-Cl, 3- c -Pr)</td>

<td>Pli(2-OC1FC Cll)</td><td>Ply(3-OC1PC CH)</td><td></td>

<td>Pli(2-OC1FC CCFF)</td><td>Ph(3-OCH_;C CCF_;)</td><td>Ph(2-Cl, 3-CH=CH2)</td>

<td>Pli(2-OC1FCCCFHI)</td><td>Ph(3-OCH2CCCP.-II)</td><td>Ph(2-Cl, 3-CF3)</td>

<td>Pli(2-OC1FCCC1F)</td><td>Ph(3-OCH2CCC1P)</td><td>Ph(2-Cl, 3-CH2CF3)</td>

<td></td><td></td><td>Ph(2-Cl, 3-CF2H)</td>

<td>Ph(2-CCCFHI)</td><td>Ph(3-CCCFL)</td><td>Ph(2-Cl, 3-CH2F)</td>

<td>Ph(2-CCC1F)</td><td>Ph(3-CCC1F)</td><td>Ph(2-Cl, 3-OCF3)</td>

<td></td><td></td><td>Ph(2-Cl, 3-OCH2F)</td>

<td></td><td></td><td>Ph(2-Cl, 3-OCF2H)</td>

<td>Ph(2-CCCFF)</td><td>Ph(3-CCCFF)</td><td>Ph(2-Cl, 3-SCF3)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-SMe)</td><td></td><td>Ph(2-F, 3-SOMe)</td>

<td>Ph(2-Cl, 3-SOMe)</td><td>Ph(2-Cl, 3-C^CCF3)</td><td>Ph(2-F, 3-SO2Me)</td>

<td>Ph(2-Cl, 3-SO2Me)</td><td>Ph(2-Cl, 3-CH=CF2)</td><td>Ph(2-F,3-OSO2Me)</td>

<td>Ph(2-Cl, 3-OSO2Me)</td><td>Ph(2-Cl, 3-CH=CCF)</td><td>Ph(2-F, 3-C^CH)</td>

<td>Ph(2-Cl, 3-C=CH)</td><td>Ph(2-Cl, 3-CH=CBr2)</td><td>Ph(2-F, 3-OMe)</td>

<td>Ph(2-Cl, 3-OMe) Ph(2-Cl, 3-OEt) Ph(2-Cl, 3-NHCOMe) Ph(2-Cl, 3-CN)</td><td>Ph(2-Cl, 3-OCH=CH2) Ph(2-Cl, 3-OCH=CF2) Ph(2-Cl, 3-OCH=CCF) Ph(2-Cl, 3-OCH=CBr2) Ph(2-Cl, 3-CH2CH=CH2) Ph(2-Cl, 3-CH2CH=CF2)</td><td>Ph(2-F,3-OEt) Ph(2-F, 3-NHCOMe) Ph(2-F, 3-NO2)</td>

<td>Ph(2-Cl, 3-NO2)</td><td>Ph(2-Cl, 3-CH2CH=CCl2) Ph(2-Cl, 3-CH2CH=CBr2)</td><td>Ph(2-F, 3-COMe) Ph(2-F, 3-OCOMe)</td>

<td>Ph(2-Cl, 3-COMe) Ph(2-Cl, 3-OCOMe) Ph(2-Cl, 3-CO2Me) Ph(2-Cl, 3-TMS)</td><td>Ph(2-Cl, 3-OCH2CH=CH2) Ph(2-Cl, 3-OCH2CH=CF2) Ph(2-Cl, 3-OCH2CH=CCl2) Ph(2-Cl, 3-OCH2CH=CBr2) Ph(2-Cl, 3-SCF2H) Ph(2-Cl, 3-SCF2CF2H) Ph(2-F, 3-F) Ph(2-F, 3-Br) Ph(2-F, 3-I) Ph(2-F, 3-Me) Ph(2-F, 3-Et)</td><td>Ph(2-F, 3-CO2Me) Ph(2-F, 3-C2F5) Ph(2-F, 3-CF2CF2H) Ph(2-F,3-OCF2CF2H) Ph(2-F, 3-OC2F5) Ph(2-F,3-OCH2CF3)</td>

<td>Ph(2-Cl, 3-C2F5)</td><td>Ph(2-F, 3-n-Pr)</td><td>Ph(2-F, 3-OCH_;C CH)</td>

<td>Ph(2-Cl, 3-CF2CF2H)</td><td>Ph(2-F, 3-1-Bu)</td><td>Ph(2-F, 3-OCH_;CCC1H)</td>

<td>Ph(2-Cl, 3-OCF2CF2H) Ph(2-Cl, 3-OC2F5) Ph(2-Cl, 3-OCH2CF3)</td><td>Ph(2-F, 3- i -Pr) Ph(2-F, 3-CH=CH)</td><td>Ph(2-F, 3-OCH_;C CCP-ll) Ph(2-F, 3-OCH_;C CC1P)</td>

<td>Ph(2-Cl, 3-OCH2C=CH)</td><td>Ph(2-F, 3-CF3)</td><td>Ph(2-F, 3-C CCF;1I)</td>

<td>Ph(2-Cl, 3-OCH2C=CCF3) Ph(2-Cl, 3-OCH2C=CCF2H) Ph(2-Cl, 3-OCH2C=CCH3)</td><td>Ph(2-F,3-CH2CF3) Ph(2-F, 3-CF2H) Ph(2-F, 3-CH2F) Ph(2-F, 3-OCH2F)</td><td>Ph(2-F, 3-C CC1P) Ph(2-F, 3-C CCP_;)</td>

<td>Ph(2-Cl, 3-C^CCF2H)</td><td>Ph(2-F, 3-OCF2H)</td><td>Ph(2-F, 3-CH=CF2)</td>

<td>Ph(2-Cl, 3-C^CCH3)</td><td>Ph(2-F, 3-SCF3) Ph(2-F, 3-SMe)</td><td>Ph(2-F, 3-CH=CCl2) Ph(2-F, 3-CH=CBr2)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-OCH=CH2)</td><td>2-furanyl(5-Cl)</td><td>Ph(4-CH=CBr2)</td>

<td>Ph(2-F, 3-OCH=CF2)</td><td>2-furanyl(5-CF3)</td><td>Ph(4-OCH=CH2)</td>

<td>Ph(2-F, 3-OCH=CCl2)</td><td>2-furanyl(4-Me)</td><td>Ph(4-OCH=CF2)</td>

<td>Ph(2-F, 3-OCH=CBr2)</td><td>2-furanyl(4-Et)</td><td>Ph(4-OCH=CCl2)</td>

<td>Ph(2-F, 3-CH2CH=CH2)</td><td>2-furanyl(4-i-Pr)</td><td>Ph(4-OCH=CBr2)</td>

<td>Ph(2-F, 3-CH2CH=CF2)</td><td>2-furanyl(4- c -Pr)</td><td>Ph(4-CH2CH=CH2)</td>

<td>Ph(2-F, 3-CH2CH=CCl2)</td><td>2-furanyl(4-CF2H)</td><td>Ph(4-CH2CH=CF2)</td>

<td>Ph(2-F, 3-CH2CH=CBr2)</td><td>2-furanyl(4-OCF2H)</td><td>Ph(4-CH2CH=CCl2)</td>

<td>Ph(2-F, 3-OCH2CH=CH2)</td><td>2-furanyl(4-OCF2CF2H)</td><td>Ph(4-CH2CH=CBr2)</td>

<td>Ph(2-F, 3-OCH2CH=CF2)</td><td>2-furanyl(5-Me)</td><td>Ph(4-OCH2CH=CH2)</td>

<td>Ph(2-F, 3-OCH2CH=CCl2)</td><td>2-furanyl(5-Et)</td><td>Ph(4-OCH2CH=CF2)</td>

<td>Ph(2-F, 3-OCH2CH=CBr2)</td><td>2-furanyl(5-i-Pr)</td><td>Ph(4-OCH2CH=CCl2)</td>

<td>Ph(2-F, 3-SCF2H)</td><td>2-furanyl(5-c-Pr)</td><td>Ph(4-OCH2CH=CBr2)</td>

<td>Ph(2-F, 3-SCF2CF2H)</td><td>2-furanyl(5-CF2H)</td><td>Ph(4-SCF2H)</td>

<td>Ph(2-F, 3-SF5)</td><td>2-furanyl(5-OCF2H)</td><td>Ph(4-SCF2CF2H)</td>

<td>4-pyridinyl(5-OCF2H)</td><td>2-furanyl(5-OCF2CF2H)</td><td>Ph(2,4-di-Cl)</td>

<td>4-pyridinyl(5-CF2H)</td><td>2-furanyl(5-OC2F5)</td><td>Ph(2-Cl, 4-F)</td>

<td>4-pyridinyl(5-OCF2CF2H)</td><td>Ph(4-I)</td><td>Ph(2-Cl, 4-Br)</td>

<td>2-thienyl(4-Me)</td><td>Ph(4-n-Pr)</td><td>Ph(2-Cl, 4-I)</td>

<td>2-thienyl(4-Et)</td><td>Ph(4-OCHF2)</td><td>Ph(2-Cl, 4-Me)</td>

<td>2-thienyl(4-i -Pr)</td><td>Ph(4-C2F5)</td><td>Ph(2-Cl, 4-Et)</td>

<td>2-thienyl(4-c -Pr)</td><td>Ph(4-CF2CF2H)</td><td>Ph(2-Cl, 4-n-Pr)</td>

<td>2-thienyl(4-CF2H)</td><td>Ph(4-OCF2CF2H)</td><td>Ph(2-Cl, 4-1-Bu)</td>

<td>2-thienyl(4-OCF2H)</td><td>Ph(4-OC2F5)</td><td>Ph(2-Cl, 4- i -Pr)</td>

<td>2-thienyl(4-OCF2CF2H)</td><td>Ph(4-OCH2CF3)</td><td>Ph(2-Cl, 4- c -Pr)</td>

<td>2-thienyl(5-Me)</td><td>Ph(4-OCH_;C CH)</td><td></td>

<td>2-thienyl(5-Et)</td><td>Pli(4-OC1HCCC1C)</td><td>Ph(2-Cl, 4-CH=CH2)</td>

<td>2-thienyl(5-i-Pr)</td><td>Pli(4-OC1HCCCF;1I)</td><td>Ph(2-Cl, 4-CF3)</td>

<td>2-thienyl(5-c -Pr)</td><td>Pli(4-OC1HC CHIP)</td><td>Ph(2-Cl, 4-CH2CF3)</td>

<td>2-thienyl(5-CF2H)</td><td></td><td>Ph(2-Cl, 4-CHF2)</td>

<td>2-thienyl(5-OCF2H)</td><td>Ph(4-C CCP-II)</td><td>Ph(2-Cl, 4-CH2F)</td>

<td>2-thienyl(5-OCF2CF2H)</td><td>Ph(4-C CCP)</td><td>Ph(2-Cl, 4-OCF3)</td>

<td>2-thienyl(5-OC2F5)</td><td></td><td>Ph(2-Cl, 4-OCH2F)</td>

<td>2-furanyl(4-F)</td><td></td><td>Ph(2-Cl, 4-OCHF2)</td>

<td>2-furanyl(4-Cl)</td><td>Ph(4-C CCF_;)</td><td>Ph(2-Cl, 4-SCF3)</td>

<td>2-furanyl(4-CF3)</td><td>Ph(4-CH=CF2)</td><td>Ph(2-Cl, 4-SMe)</td>

<td>2-furanyl(5-F)</td><td>Ph(4-CH=CCl2)</td><td>Ph(2-Cl, 4-SOMe)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 4-SO2Me)</td><td>Ph(2-Cl, 4-OCH=CBr2)</td><td></td>

<td>Ph(2-Cl, 4-OSO2Me)</td><td>Ph(2-Cl, 4-CH2CH=CH2)</td><td>Ph(2-F, 4-NHCOMe)</td>

<td>Ph(2-Cl, 4-C=CH)</td><td>Ph(2-Cl, 4-CH2CH=CF2)</td><td></td>

<td>Ph(2-Cl, 4-OMe)</td><td>Ph(2-Cl, 4-CH2CH=CCl2)</td><td>Ph(2-F, 4-CN)</td>

<td>Ph(2-Cl, 4-OEt)</td><td>Ph(2-Cl, 4-CH2CH=CBr2) Ph(2-Cl, 4-OCH2CH=CH2)</td><td>Ph(2-F, 4-NO2)</td>

<td>Ph(2-Cl, 4-NHCOMe)</td><td>Ph(2-Cl, 4-OCH2CH=CF2)</td><td>Ph(2-F, 4-COMe)</td>

<td></td><td>Ph(2-Cl, 4-OCH2CH=CCl2)</td><td>Ph(2-F, 4-OCOMe)</td>

<td>Ph(2-Cl, 4-CN)</td><td>Ph(2-Cl, 4-OCH2CH=CBr2)</td><td>Ph(2-F, 4-CO2Me)</td>

<td>Ph(2-Cl, 4-NO2)</td><td>Ph(2-Cl, 4-SCF2H) Ph(2-Cl, 4-SCF2CF2H)</td><td>Ph(2-F, 4-C2F5)</td>

<td>Ph(2-Cl, 4-COMe)</td><td>Ph(2-F, 4-Cl)</td><td>Ph(2-F, 4-CF2CF2H)</td>

<td>Ph(2-Cl, 4-OCOMe)</td><td>Ph(2,4-di-F)</td><td>Ph(2-F, 4-OCF2CF2H)</td>

<td>Ph(2-Cl, 4-CO2Me)</td><td>Ph(2-F, 4-Br)</td><td>Ph(2-F, 4-OC2F5)</td>

<td></td><td>Ph(2-F, 4-I)</td><td>Ph(2-F,4-OCH2CF3)</td>

<td>Ph(2-Cl, 4-TMS)</td><td>Ph(2-F, 4-Me)</td><td>Ph(2-F, 4-OCH_;C CH)</td>

<td>Ph(2-Cl, 4-C2F5)</td><td>Ph(2-F,4-Et)</td><td>Ph(2-F, 4-OCH_;CCP_;)</td>

<td>Ph(2-Cl, 4-CF2CF2H)</td><td>Ph(2-F, 4-n-Pr)</td><td>Ph(2-F, 4-OCH_;C CCP-ll)</td>

<td>Ph(2-Cl, 4-OCF2CF2H)</td><td>Ph(2-F, 4-1-Bu)</td><td>Ph(2-F, 4-OCH_;C CC1P)</td>

<td>Ph(2-Cl, 4-OC2F5) Ph(2-Cl, 4-OCH2CF3)</td><td>Ph(2-F, 4- i -Pr)</td><td>Ph(2-F, 4-C CCF;1I)</td>

<td>Ph(2-Cl, 4-OCH2C=CH)</td><td>Ph(2-F, 4-CH=CH)</td><td>Ph(2-F, 4-C CC1P)</td>

<td>Ph(2-Cl, 4-OCH2C=CCF3)</td><td>Ph(2-F, 4-CF3)</td><td></td>

<td>Ph(2-Cl, 4-OCH2C=CCF2H)</td><td>Ph(2-F,4-CH2CF3)</td><td></td>

<td>РЬ(2-С1, 4-ОСН2С=ССНз)</td><td>Ph(2-F, 4-CHF2)</td><td>Ph(2-F, 4-C CCP_;)</td>

<td></td><td>Ph(2-F, 4-CH2F)</td><td>Ph(2-F, 4-CH=CF2)</td>

<td>Ph(2-Cl, 4-C^CCF2H)</td><td>Ph(2-F, 4-OCF3)</td><td>Ph(2-F, 4-CH=CCl2)</td>

<td>РЬ(2-С1, 4-С^ССНз)</td><td>Ph(2-F, 4-OCH2F)</td><td>Ph(2-F, 4-CH=CBr2)</td>

<td></td><td>Ph(2-F, 4-OCHF2)</td><td>Ph(2-F, 4-OCH=CH2)</td>

<td></td><td>Ph(2-F, 4-SCF3)</td><td>Ph(2-F, 4-OCH=CF2)</td>

<td>Ph(2-Cl, 4-C^CCF3)</td><td>Ph(2-F, 4-SMe)</td><td>Ph(2-F, 4-OCH=CCl2)</td>

<td>Ph(2-Cl, 4-CH=CF2)</td><td>Ph(2-F, 4-SOMe)</td><td>Ph(2-F, 4-OCH=CBr2)</td>

<td>Ph(2-Cl, 4-CH=CCF)</td><td>Ph(2-F, 4-SO2Me)</td><td>Ph(2-F, 4-CH2CH=CH2)</td>

<td>Ph(2-Cl, 4-CH=CBr2)</td><td>Ph(2-F,4-OSO2Me)</td><td>Ph(2-F, 4-CH2CH=CF2)</td>

<td>Ph(2-Cl, 4-OCH=CH2)</td><td>Ph(2-F, 4-C CH)</td><td>Ph(2-F, 4-CH2CH=CCl2)</td>

<td>Ph(2-Cl, 4-OCH=CF2)</td><td>Ph(2-F, 4-OMe)</td><td>Ph(2-F, 4-CH2CH=CBr2)</td>

<td>Ph(2-Cl, 4-OCH=CCF)</td><td>Ph(2-F,4-OEt)</td><td>Ph(2-F, 4-OCH2CH=CH2)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 4-OCH2CH=CF2)</td><td>Ph(3-Cl, 4-OC2F5)</td><td>Ph(3-I, 4-OMe)</td>

<td>Ph(2-F, 4-OCH2CH=CCl2)</td><td>Ph(3, 4-di-F)</td><td>Ph(3-I, 4-OCF3)</td>

<td>Ph(2-F, 4-OCH2CH=CBr2)</td><td>Ph(3-F, 4-I)</td><td>Ph(3-I,4-OCHF2)</td>

<td>Ph(2-F, 4-SCF2H)</td><td>Ph(3-F,4-Et)</td><td>Ph(3-I, 4-OCF2CF2H)</td>

<td>Ph(2-F, 4-SCF2CF2H)</td><td>Ph(3-F, 4-n-Pr)</td><td>Ph(3-I, 4-OC2F5)</td>

<td>Ph(2-F, 4-SF5)</td><td>Ph(3-F, 4- i -Pr)</td><td>Ph(3-I, 4-SO2Me)</td>

<td>3-pyridinyl(5-OCF2H)</td><td>Ph(3-F, 4-C2F5)</td><td>Ph(3-I,4-TMS)</td>

<td>3-pyridinyl(5-CF2H)</td><td>Ph(3-F, 4-CF2CF2H)</td><td>Ph(3-I, 4-CN)</td>

<td>3-pyridinyl(5-OCF2CF2H)</td><td>Ph(3-F, 4-CF2H)</td><td>Ph(3-Me, 4-I)</td>

<td>3-thienyl(4-Me)</td><td>Ph(3-F, 4-OMe)</td><td>Ph(3-Me, 4-Et)</td>

<td>3-thienyl(4-Et)</td><td>Ph(3-F,4-OCF2CF2H)</td><td>Ph(3-Me, 4-n-Pr)</td>

<td>3-thienyl(4-i -Pr)</td><td>Ph(3-F,4-OC2F5)</td><td>Ph(3-Me, 4-i -Pr)</td>

<td>3-thienyl(4-c -Pr)</td><td>Ph(3-Br, 4-I)</td><td>Ph(3-Me, 4-C2F5)</td>

<td>3-thienyl(4-CF2H)</td><td>Ph(3-Br, 4-Et)</td><td>Ph(3-Me, 4-CF2CF2H)</td>

<td>3-thienyl(4-OCF2H)</td><td>Ph(3-Br, 4-n-Pr)</td><td>Ph(3-Me, 4-CF2H)</td>

<td>3-thienyl(4-OCF2CF2H)</td><td>Ph(3-Br, 4-1-Bu)</td><td>Ph(3-Me, 4-OMe)</td>

<td>3-thienyl(4-OC2F5)</td><td>Ph(3-Br, 4- i -Pr)</td><td>Ph(3-Me, 4-OCF2CF2H)</td>

<td>3-furanyl(5-F)</td><td>Ph(3-Br, 4-C2F5)</td><td>Ph(3-Me, 4-OC2F5)</td>

<td>3-furanyl(5-Cl)</td><td>Ph(3-Br, 4-CF2CF2H)</td><td>Ph(3-Et,4-Cl)</td>

<td>3-furanyl(5-CF3)</td><td>Ph(3-Br, 4-CF2H)</td><td>Ph(3-Et,4-F)</td>

<td>3-furanyl(4-Me)</td><td>Ph(3-Br, 4-OMe)</td><td>Ph(3-Et, 4-Br)</td>

<td>3-furanyl(4-Et)</td><td>Ph(3-Br, 4-OCF2CF2H)</td><td>Ph(3-Et,4-I)</td>

<td>3-furanyl(4-i-Pr)</td><td>Ph(3-Br, 4-OC2F5)</td><td>Ph(3-Et,4-Me)</td>

<td>3-furanyl(4- c -Pr)</td><td>Ph(3-I, 4-Cl)</td><td>Ph(3,4-di-Et)</td>

<td>3-furanyl(4-CF2H)</td><td>Ph(3-I, 4-F)</td><td>Ph(3-Et, 4-n-Pr)</td>

<td>3-furanyl(4-OCF2H)</td><td>Ph(3-I, 4-Br)</td><td>Ph(3-Et, 4-1-Bu)</td>

<td>3-furanyl(4-OCF2CF2H)</td><td>Ph(3,4-di-I)</td><td>Ph(3-Et, 4- i -Pr)</td>

<td>3-furanyl(4-OC2F5)</td><td>Ph(3-I, 4-Me)</td><td>Ph(3-Et, 4- c -Pr)</td>

<td>Ph(3-Cl, 4-I)</td><td>Ph(3-I,4-Et)</td><td>Ph(3-Et, 4-CF3)</td>

<td>Ph(3-Cl, 4-Et)</td><td>Ph(3-I, 4-n-Pr)</td><td>Ph(3-Et, 4-C2F5)</td>

<td>Ph(3-Cl, 4-n-Pr)</td><td>Ph(3-I,4-1-Bu)</td><td>Ph(3-Et, 4-CF2CF2H)</td>

<td>Ph(3-Cl, 4- i -Pr)</td><td>Ph(3-I, 4- i -Pr)</td><td>Ph(3-Et, 4-CF2H)</td>

<td>Ph(3-Cl, 4-C2F5)</td><td>Ph(3-I, 4- c -Pr)</td><td>Ph(3-Et, 4-OMe)</td>

<td>Ph(3-Cl, 4-CF2CF2H)</td><td>Ph(3-I, 4-CF3)</td><td>Ph(3-Et, 4-OCF3)</td>

<td>Ph(3-Cl, 4-CF2H)</td><td>Ph(3-I, 4-C2F5)</td><td>Ph(3-Et, 4-OCHF2)</td>

<td>Ph(3-Cl, 4-OMe)</td><td>Ph(3-I, 4-CF2CF2H)</td><td>Ph(3-Et, 4-OCF2CF2H)</td>

<td>Ph(3-Cl, 4-OCF2CF2H)</td><td>Ph(3-I, 4-CF2H)</td><td>Ph(3-Et, 4-OC2F5)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-Et, 4-SO2Me)</td><td>Ph(3- i -Pr, 4-Br)</td><td>Ph(3-CF3, 4-OMe)</td>

<td>Ph(3-Et, 4-TMS)</td><td>Ph(3- i -Pr, 4-I)</td><td>Ph(3-CF3, 4-OCF2CF2H)</td>

<td>Ph(3-Et, 4-CN)</td><td>Ph(3- i -Pr, 4-Me)</td><td>Ph(3-CF3, 4-OC2F5)</td>

<td>Ph(3-n-Pr, 4-Cl)</td><td>Ph(3- i -Pr, 4-Et)</td><td>Ph(3-CF3,4-TMS)</td>

<td>Ph(3-n-Pr, 4-F)</td><td>Ph(3-i-Pr, 4-n-Pr)</td><td>Ph(3-C2F5, 4-Cl)</td>

<td>Ph(3-n-Pr, 4-Br)</td><td>Ph(3- i -Pr, 4-1-Bu)</td><td>Ph(3-C2F5,4-F)</td>

<td>Ph(3-n-Pr, 4-I)</td><td>Ph(3, 4-di-i-Pr)</td><td>Ph(3-C2F5,4-Br)</td>

<td>Ph(3-n-Pr, 4-Me)</td><td>Ph(3- i -Pr, 4- c -Pr)</td><td>Ph(3-C2F5,4-I)</td>

<td>Ph(3-n-Pr, 4-Et)</td><td>Ph(3- i -Pr, 4-CF3)</td><td>Ph(3-C2F5,4-Me)</td>

<td>Ph(3, 4-di-n-Pr)</td><td>Ph(3- i -Pr, 4-C2F5)</td><td>Ph(3-C2F5,4-Et)</td>

<td>Ph(3-n-Pr, 4-1-Bu)</td><td>Ph(3- i -Pr, 4-CF2CF2H)</td><td>Ph(3-C2F5, 4-n-Pr)</td>

<td>Ph(3- n -Pr, 4- i -Pr)</td><td>Ph(3- i -Pr, 4-CF2H)</td><td>Ph(3-C2F5,4-1-Bu)</td>

<td>Ph(3-n-Pr, 4-c-Pr)</td><td>Ph(3- i -Pr, 4-OMe)</td><td>Ph(3-C2F5, 4- i -Pr)</td>

<td>Ph(3-n-Pr, 4-CF3)</td><td>Ph(3- i -Pr, 4-OCF3)</td><td>Ph(3-C2F5, 4- c -Pr)</td>

<td>Ph(3-n-Pr, 4-C2F5)</td><td>Ph(3- i -Pr, 4-OCHF2)</td><td>Ph(3-C2F5CF3, 4-CF3)</td>

<td>Ph(3-n-Pr, 4-CF2CF2H)</td><td>Ph(3- i -Pr, 4-OCF2CF2H)</td><td>Ph(3, 4-di-C2F5)</td>

<td>Ph(3-n-Pr, 4-CF2H)</td><td>Ph(3- i -Pr, 4-OC2F5)</td><td>Ph(3-C2F5, 4-CF2CF2H)</td>

<td>Ph(3-n-Pr, 4-OMe)</td><td>Ph(3- i -Pr, 4-SO2Me)</td><td>Ph(3-C2F5,4-CF2H)</td>

<td>Ph(3-n-Pr, 4-OCF3)</td><td>Ph(3- i -Pr, 4-TMS)</td><td>Ph(3-C2F5, 4-OMe)</td>

<td>Ph(3-n-Pr, 4-OCHF2)</td><td>Ph(3- i -Pr, 4-CN)</td><td>Ph(3-C2F5, 4-OCF3)</td>

<td>Ph(3-n-Pr, 4-OCF2CF2H)</td><td>Ph(3- c -Pr, 4-I)</td><td>Ph(3-C2F5, 4-OCHF2)</td>

<td>Ph(3-n-Pr, 4-OC2F5)</td><td>Ph(3- c -Pr, 4-Et)</td><td>Ph(3-C2F5, 4-OCF2CF2H)</td>

<td>Ph(3-n-Pr, 4-SO2Me)</td><td>Ph(3-c-Pr, 4-n-Pr)</td><td>Ph(3-C2F5, 4-OC2F5)</td>

<td>Ph(3-n-Pr, 4-TMS)</td><td>Ph(3- c -Pr, 4- i -Pr)</td><td>Ph(3-C2F5, 4-SO2Me)</td>

<td>Ph(3-n-Pr, 4-CN)</td><td>Ph(3-c-Pr, 4-C2F5)</td><td>Ph(3-C2F5,4-TMS)</td>

<td>Ph(3-1-Bu, 4-I)</td><td>Ph(3- c -Pr, 4-CF2CF2H)</td><td>Ph(3-C2F5,4-CN)</td>

<td>Ph(3-1-Bu, 4-Et)</td><td>Ph(3- c -Pr, 4-CF2H)</td><td>Ph(3-CF2CF2H, 4-Cl)</td>

<td>Ph(3-1-Bu, 4-n-Pr)</td><td>Ph(3- c -Pr, 4-OMe)</td><td>Ph(3-CF2CF2H, 4-F)</td>

<td>Ph(3-1-Bu, 4-i-Pr)</td><td>Ph(3- c -Pr, 4-OCF2CF2H)</td><td>Ph(3-CF2CF2H, 4-Br)</td>

<td>Ph(3-1-Bu, 4-C2F5)</td><td>Ph(3- c -Pr, 4-OC2F5)</td><td>Ph(3-CF2CF2H, 4-I)</td>

<td>Ph(3-1-Bu, 4-CF2CF2H)</td><td>Ph(3-CF3,4-I)</td><td>Ph(3-CF2CF2H, 4-Me)</td>

<td>Ph(3-1-Bu, 4-CF2H)</td><td>Ph(3-CF3,4-Et)</td><td>Ph(3-CF2CF2H, 4-Et)</td>

<td>Ph(3-1-Bu, 4-OMe)</td><td>Ph(3-CF3,4-n-Pr)</td><td>Ph(3-CF2CF2H, 4-n-Pr)</td>

<td>Ph(3-1-Bu, 4-OCF2CF2H)</td><td>Ph(3-CF3, 4- i -Pr)</td><td>Ph(3-CF2CF2H, 4-1-Bu)</td>

<td>Ph(3-1-Bu, 4-OC2F5)</td><td>Ph(3-CF3, 4-C2F5)</td><td>Ph(3-CF2CF2H, 4- i -Pr)</td>

<td>Ph(3- i -Pr, 4-Cl)</td><td>Ph(3-CF3, 4-CF2CF2H)</td><td>Ph(3-CF2CF2H, 4- c -Pr)</td>

<td>Ph(3- i -Pr, 4-F)</td><td>Ph(3-CF3, 4-CF2H)</td><td>Ph(3-CF2CF2H, 4-CF3)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-CF2CF2H, 4-C2F5)</td><td>Ph(3-OMe, 4-Me)</td><td>Ph(3-OCHF2, 4- i -Pr)</td>

<td>Ph(3, 4-di-CF2CF2H)</td><td>Ph(3-OMe, 4-Et)</td><td>Ph(3-OCHF2, 4- c -Pr)</td>

<td>Ph(3-CF2CF2H, 4-CF2H)</td><td>Ph(3-OMe, 4-n-Pr)</td><td>Ph(3-OCHF2CF3, 4-CF3)</td>

<td>Ph(3-CF2CF2H, 4-OMe)</td><td>Ph(3-OMe, 4-1-Bu)</td><td>Ph(3-OC2F5, 4-C2F5)</td>

<td>Ph(3-CF2CF2H, 4-OCF3)</td><td>Ph(3-OMe, 4- i -Pr)</td><td>Ph(3-OCHF2, 4-CF2CF2H)</td>

<td>Ph(3-CF2CF2H, 4-OCHF2)</td><td>Ph(3-OMe, 4- c -Pr)</td><td>Ph(3-OCHF2, 4-CF2H)</td>

<td>Ph(3-CF2CF2H, 4-OCF2CF2H)</td><td>Ph(3-OMe, 4-CF3)</td><td>Ph(3-OCHF2, 4-OMe)</td>

<td>Ph(3-CF2CF2H, 4-OC2F5)</td><td>Ph(3-OMe, 4-C2F5)</td><td>Ph(3-OCHF2, 4-OCF3)</td>

<td>Ph(3-CF2CF2H, 4-SO2Me)</td><td>Ph(3-OMe, 4-CF2CF2H)</td><td>Ph(3, 4-di-OCHF2)</td>

<td>Ph(3-CF2CF2H, 4-TMS)</td><td>Ph(3-OMe, 4-CF2H)</td><td>Ph(3-OCHF2, 4-OCF2CF2H)</td>

<td>Ph(3-CF2CF2H, 4-CN)</td><td>Ph(3, 4-di-OMe)</td><td>Ph(3-OCHF2, 4-OC2F5)</td>

<td>Ph(3-CF2H,4-Cl)</td><td>Ph(3-OMe, 4-OCF3)</td><td>Ph(3-OCHF2, 4-SO2Me)</td>

<td>Ph(3-CF2H,4-F)</td><td>Ph(3-OMe, 4-OCHF2)</td><td>Ph(3-OCHF2, 4-TMS)</td>

<td>Ph(3-CF2H,4-Br)</td><td>Ph(3-OMe, 4-OCF2CF2H)</td><td>Ph(3-OCHF2, 4-CN)</td>

<td>Ph(3-CF2H,4-I)</td><td>Ph(3-OMe, 4-OC2F5)</td><td>Ph(3-OCF2CF2H, 4-Cl)</td>

<td>Ph(3-CF2H, 4-Me)</td><td>Ph(3-OMe, 4-SO2Me)</td><td>Ph(3-OCF2CF2H, 4-F)</td>

<td>Ph(3-CF2H,4-Et)</td><td>Ph(3-OMe, 4-TMS)</td><td>Ph(3-OCF2CF2H, 4-Br)</td>

<td>Ph(3-CF2H, 4-n-Pr)</td><td>Ph(3-OMe, 4-CN)</td><td>Ph(3-OCF2CF2H, 4-I)</td>

<td>Ph(3-CF2H, 4-1-Bu)</td><td>Ph(3-OCF3, 4-I)</td><td>Ph(3-OCF2CF2H, 4-Me)</td>

<td>Ph(3-CF2H, 4- i -Pr)</td><td>Ph(3-OCF3, 4-Et)</td><td>Ph(3-OCF2CF2H, 4-Et)</td>

<td>Ph(3-CF2H, 4- c -Pr)</td><td>Ph(3-OCF3, 4-n-Pr)</td><td>Ph(3-OCF2CF2H, 4-n-Pr)</td>

<td>Ph(3-CF2H, 4-CF3)</td><td>Ph(3-OCF3, 4- i -Pr)</td><td>Ph(3-OCF2CF2H, 4-1-Bu)</td>

<td>Ph(3-CF2H,4-C2F5)</td><td>Ph(3-OCF3, 4-CF3)</td><td>Ph(3-OCF2CF2H, 4- i -Pr)</td>

<td>Ph(3-CF2H, 4-CF2CF2H)</td><td>Ph(3-OCF3, 4-C2F5)</td><td>Ph(3-OCF2CF2H, 4- c -Pr)</td>

<td>Ph(3,4-di-CF2H)</td><td>Ph(3-OCF3, 4-CF2CF2H)</td><td>Ph(3-OCF2CF2H, 4-CF3)</td>

<td>Ph(3-CF2H, 4-OMe)</td><td>Ph(3-OCF3, 4-CF2H)</td><td>Ph(3-OCF2CF2H, 4-C2F5)</td>

<td>Ph(3-CF2H, 4-OCF3)</td><td>Ph(3-OCF3, 4-OMe)</td><td>Ph(3-OCF2CF2H, 4-CF2CF2H)</td>

<td>Ph(3-CF2H, 4-OCHF2)</td><td>Ph(3-OCF3, 4-OCF2CF2H)</td><td>Ph(3-OCF2CF2H, 4-CF2H)</td>

<td>Ph(3-CF2H, 4-OCF2CF2H)</td><td>Ph(3-OCF3, 4-OC2F5)</td><td>Ph(3-OCF2CF2H, 4-OMe)</td>

<td>Ph(3-CF2H,4-OC2F5)</td><td>Ph(3-OCHF2, 4-Cl)</td><td>Ph(3-OCF2CF2H, 4-OCF3)</td>

<td>Ph(3-CF2H, 4-SO2Me)</td><td>Ph(3-OCHF2,4-F)</td><td>Ph(3-OCF2CF2H, 4-OCHF2)</td>

<td>Ph(3-CF2H, 4-TMS)</td><td>Ph(3-OCHF2,4-Br)</td><td>Ph(3, 4-di-OCF2CF2H)</td>

<td>Ph(3-CF2H,4-CN)</td><td>Ph(3-OCHF2,4-I)</td><td>Ph(3-OCF2CF2H, 4-OC2F5)</td>

<td>Ph(3-OMe, 4-Cl)</td><td>Ph(3-OCHF2, 4-Me)</td><td>Ph(3-OCF2CF2H, 4-SO2Me)</td>

<td>Ph(3-OMe, 4-F)</td><td>Ph(3-OCHF2, 4-Et)</td><td>Ph(3-OCF2CF2H, 4-TMS)</td>

<td>Ph(3-OMe, 4-Br)</td><td>Ph(3-OCHF2, 4-n-Pr)</td><td>Ph(3-OCF2CF2H, 4-CN)</td>

<td>Ph(3-OMe, 4-I)</td><td>Ph(3-OCHF2, 4-1-Bu)</td><td>Ph(3-OC2F5, 4-Cl)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-OC2F5,4-F)</td><td>Ph(3-TMS, 4-n-Pr)</td><td>Ph(3-Cl, 5-C2F5)</td>

<td>Ph(3-OC2F5, 4-Br)</td><td>Ph(3-TMS, 4-1-Bu)</td><td>Ph(3-Cl, 5-CF2CF2H)</td>

<td>Ph(3-OC2F5,4-I)</td><td>Ph(3-TMS, 4- i -Pr)</td><td>Ph(3-Cl, 5-CF2H)</td>

<td>Ph(3-OC2F5, 4-Me)</td><td>Ph(3-TMS, 4- c -Pr)</td><td>Ph(3-Cl, 5-OMe)</td>

<td>Ph(3-OC2F5,4-Et)</td><td>Ph(3-TMS, 4-CF3)</td><td>Ph(3-Cl, 5-OCF3)</td>

<td>Ph(3-OC2F5, 4-n-Pr)</td><td>Ph(3-TMS, 4-C2F5)</td><td>Ph(3-Cl, 5-OCHF2)</td>

<td>Ph(3-OC2F5,4-1-Bu)</td><td>Ph(3-TMS, 4-CF2CF2H)</td><td>Ph(3-Cl, 5-OCF2CF2H)</td>

<td>Ph(3-OC2F5, 4- i -Pr)</td><td>Ph(3-TMS, 4-CF2H)</td><td>Ph(3-Cl, 5-OC2F5)</td>

<td>Ph(3-OC2F5, 4-c -Pr)</td><td>Ph(3-TMS, 4-OMe)</td><td>Ph(3-Cl, 5-SO2Me)</td>

<td>Ph(3-OC2F5CF3, 4-CF3)</td><td>Ph(3-TMS, 4-OCF3)</td><td>Ph(3-Cl, 5-TMS)</td>

<td>Ph(3-OC2F5, 4-CF2CF2H)</td><td>Ph(3-TMS, 4-OCHF2)</td><td>Ph(3-Cl, 5-CN)</td>

<td>Ph(3-OC2F5, 4-CF2H)</td><td>Ph(3-TMS, 4-OCF2CF2H)</td><td>Ph(3-F, 5-Cl)</td>

<td>Ph(3-OC2F5, 4-OMe)</td><td>Ph(3-TMS, 4-OC2F5)</td><td>Ph(3, 5-di-F)</td>

<td>Ph(3-OC2F5, 4-OCF3)</td><td>Ph(3-TMS, 4-SO2Me)</td><td>Ph(3-F, 5-Br)</td>

<td>Ph(3-OC2F5, 4-OCHF2)</td><td>Ph(3,4-di-TMS)</td><td>Ph(3-F, 5-I)</td>

<td>Ph(3-OC2F5, 4-OCF2CF2H)</td><td>Ph(3-TMS, 4-CN)</td><td>Ph(3-F, 5-Me)</td>

<td>Ph(3, 4-di-OC2F5)</td><td>Ph(3-CN,4-I)</td><td>Ph(3-F,5-Et)</td>

<td>Ph(3-OC2F5, 4-SO2Me)</td><td>Ph(3-CN,4-Et)</td><td>Ph(3-F, 5-n-Pr)</td>

<td>Ph(3-OC2F5,4-TMS)</td><td>Ph(3-CN, 4-n-Pr)</td><td>Ph(3-F, 5-1-Bu)</td>

<td>Ph(3-OC2F5,4-CN)</td><td>Ph(3-CN, 4- i -Pr)</td><td>Ph(3-F, 5- i -Pr)</td>

<td>Ph(3-SO2Me, 4-I)</td><td>Ph(3-CN, 4-C2F5)</td><td>Ph(3-F, 5- c -Pr)</td>

<td>Ph(3-SO2Me, 4-Et)</td><td>Ph(3-CN, 4-CF2CF2H)</td><td>Ph(3-F, 5-CF3)</td>

<td>Ph(3-SO2Me, 4-n-Pr)</td><td>Ph(3-CN, 4-CF2H)</td><td>Ph(3-F, 5-C2F5)</td>

<td>Ph(3-SO2Me, 4- i -Pr)</td><td>Ph(3-CN, 4-OMe)</td><td>Ph(3-F, 5-CF2CF2H)</td>

<td>Ph(3-SO2MeCF3, 4-CF3)</td><td>Ph(3-CN, 4-OCF2CF2H)</td><td>Ph(3-F, 5-CF2H)</td>

<td>Ph(3-SO2Me, 4-C2F5)</td><td>Ph(3-CN, 4-OC2F5)</td><td>Ph(3-F, 5-OMe)</td>

<td>Ph(3-SO2Me, 4-CF2CF2H)</td><td>Ph(3, 5-di-Cl)</td><td>Ph(3-F, 5-OCF3)</td>

<td>Ph(3-SO2Me, 4-CF2H)</td><td>Ph(3-Cl, 5-F)</td><td>Ph(3-F,5-OCHF2)</td>

<td>Ph(3-SO2Me, 4-OMe)</td><td>Ph(3-Cl, 5-Br)</td><td>Ph(3-F,5-OCF2CF2H)</td>

<td>Ph(3-SO2Me, 4-OCF2CF2H)</td><td>Ph(3-Cl, 5-I)</td><td>Ph(3-F, 5-OC2F5)</td>

<td>Ph(3-SO2Me, 4-OC2F5)</td><td>Ph(3-Cl, 5-Me)</td><td>Ph(3-F, 5-SO2Me)</td>

<td>Ph(3-TMS, 4-Cl)</td><td>Ph(3-Cl, 5-Et)</td><td>Ph(3-F,5-TMS)</td>

<td>Ph(3-TMS, 4-F)</td><td>Ph(3-Cl, 5-n-Pr)</td><td>Ph(3-F, 5-CN)</td>

<td>Ph(3-TMS, 4-Br)</td><td>Ph(3-Cl, 5-1-Bu)</td><td>Ph(3-Br, 5-Cl)</td>

<td>Ph(3-TMS, 4-I)</td><td>Ph(3-Cl, 5- i -Pr)</td><td>Ph(3-Br, 5-F)</td>

<td>Ph(3-TMS, 4-Me)</td><td>Ph(3-Cl, 5- c -Pr)</td><td>Ph(3,5-di-Br)</td>

<td>Ph(3-TMS, 4-Et)</td><td>Ph(3-Cl, 5-CF3)</td><td>Ph(3-Br,5-I)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-Br, 5-Me)</td><td>Ph(3-I, 5-SO2Me)</td><td>Ph(3-Et, 5-CF2CF2H)</td>

<td>Ph(3-Br, 5-Et)</td><td>Ph(3-I,5-TMS)</td><td>Ph(3-Et, 5-CF2H)</td>

<td>Ph(3-Br, 5-n-Pr)</td><td>Ph(3-I,5-CN)</td><td>Ph(3-Et, 5-OMe)</td>

<td>Ph(3-Br, 5-1-Bu)</td><td>Ph(3-Me, 5-Cl)</td><td>Ph(3-Et, 5-OCF3)</td>

<td>Ph(3-Br, 5- i -Pr)</td><td>Ph(3-Me, 5-F)</td><td>Ph(3-Et, 5-OCHF2)</td>

<td>Ph(3-Br, 5- c -Pr)</td><td>Ph(3-Me, 5-Br)</td><td>Ph(3-Et, 5-OCF2CF2H)</td>

<td>Ph(3-Br, 5-CF3)</td><td>Ph(3-Me, 5-I)</td><td>Ph(3-Et, 5-OC2F5)</td>

<td>Ph(3-Br, 5-C₂F5)</td><td>Ph(3, 5-di-Me)</td><td>Ph(3-Et, 5-SO2Me)</td>

<td>Ph(3-Br, 5-CF₂CF₂h)</td><td>Ph(3-Me, 5-Et)</td><td>Ph(3-Et, 5-TMS)</td>

<td>Ph(3-Br, 5-CF2H)</td><td>Ph(3-Me, 5-n-Pr)</td><td>Ph(3-Et,5-CN)</td>

<td>Ph(3-Br, 5-OMe)</td><td>Ph(3-Me, 5-t-Bu)</td><td>Ph(3-n-Pr, 5-Cl)</td>

<td>Ph(3-Br, 5-OCF3)</td><td>Ph(3-Me, 5-i -Pr)</td><td>Ph(3-n-Pr, 5-F)</td>

<td>Ph(3-Br, 5-OCHF2)</td><td>Ph(3-Me, 5- c -Pr)</td><td>Ph(3-n-Pr, 5-Br)</td>

<td>Ph(3-Br, 5-OCF2CF2H)</td><td>Ph(3-Me, 5-CF3)</td><td>Ph(3-n-Pr, 5-I)</td>

<td>Pli(3-Br, 5-OCT.)</td><td>Ph(3-Me, 5-C2F5)</td><td>Ph(3-n-Pr, 5-Me)</td>

<td>Ph(3-Br, 5-SO2Me)</td><td>Ph(3-Me, 5-CF2CF2H)</td><td>Ph(3-n-Pr, 5-Et)</td>

<td>Ph(3-Br, 5-TMS)</td><td>Ph(3-Me, 5-CF2H)</td><td>Ph(3, 5-di-n-Pr)</td>

<td>Ph(3-Br, 5-CN)</td><td>Ph(3-Me, 5-OMe)</td><td>Ph(3-n-Pr, 5-1-Bu)</td>

<td>Ph(3-I, 5-Cl)</td><td>Ph(3-Me, 5-OCF3)</td><td>Ph(3- n -Pr, 5- i -Pr)</td>

<td>Ph(3-I, 5-F)</td><td>Ph(3-Me, 5-OCHF2)</td><td>Ph(3-n-Pr, 5-c-Pr)</td>

<td>Ph(3-I, 5-Br)</td><td>Ph(3-Me, 5-OCF2CF2H)</td><td>Ph(3-n-Pr, 5-CF3)</td>

<td>Ph(3,5-di-I)</td><td>Ph(3-Me, 5-OC2F5)</td><td>Ph(3-n-Pr, 5-C2F5)</td>

<td>Ph(3-I, 5-Me)</td><td>Ph(3-Me, 5-SO2Me)</td><td>Ph(3-n-Pr, 5-CF2CF2H)</td>

<td>Ph(3-I, 5-Et)</td><td>Ph(3-Me, 5-TMS)</td><td>Ph(3-n-Pr, 5-CF2H)</td>

<td>Ph(3-I, 5-n-Pr)</td><td>Ph(3-Me, 5-CN)</td><td>Ph(3-n-Pr, 5-OMe)</td>

<td>Ph(3-I,5-1-Bu)</td><td>Ph(3-Et,5-Cl)</td><td>Ph(3-n-Pr, 5-OCF3)</td>

<td>Ph(3-I, 5- i -Pr)</td><td>Ph(3-Et,5-F)</td><td>Ph(3-n-Pr, 5-OCHF2)</td>

<td>Ph(3-I, 5- c -Pr)</td><td>Ph(3-Et, 5-Br)</td><td>Ph(3-n-Pr, 5-OCF2CF2H)</td>

<td>Ph(3-I, 5-CF3)</td><td>Ph(3-Et,5-I)</td><td>Ph(3-n-Pr, 5-OC2F5)</td>

<td>Ph(3-I, 5-C2F5)</td><td>Ph(3-Et,5-Me)</td><td>Ph(3-n-Pr, 5-SO2Me)</td>

<td>Ph(3-I, 5-CF2CF2H)</td><td>Ph(3, 5-di-Et)</td><td>Ph(3-n-Pr, 5-TMS)</td>

<td>Ph(3-I, 5-CF2H)</td><td>Ph(3-Et, 5-n-Pr)</td><td>Ph(3-n-Pr, 5-CN)</td>

<td>Ph(3-I, 5-OMe)</td><td>Ph(3-Et, 5-1-Bu)</td><td>Ph(3-1-Bu, 5-Cl)</td>

<td>Ph(3-I, 5-OCF3)</td><td>Ph(3-Et, 5- i -Pr)</td><td>Ph(3-1-Bu, 5-F)</td>

<td>Ph(3-I,5-OCHF2)</td><td>Ph(3-Et, 5- c -Pr)</td><td>Ph(3-1-Bu, 5-Br)</td>

<td>Ph(3-I, 5-OCF2CF2H)</td><td>Ph(3-Et, 5-CF3)</td><td>Ph(3-1-Bu, 5-I)</td>

<td>Ph(3-I, 5-OC2F5)</td><td>Ph(3-Et, 5-C2F5)</td><td>Ph(3-1-Bu, 5-Me)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-1-Bu, 5-Et)</td><td>Ph(3- i -Pr, 5-TMS)</td><td>Ph(3-CF3,5-CF2H)</td>

<td>Ph(3-1-Bu, 5-n-Pr)</td><td>Ph(3- i -Pr, 5-CN)</td><td>Ph(3-CF3, 5-OMe)</td>

<td>Ph(3,5-di-1-Bu)</td><td>Ph(3- c -Pr, 5-Cl)</td><td>Ph(3-CF3, 5-OCF3)</td>

<td>Ph(3-1-Bu, 5-i-Pr)</td><td>Ph(3- c -Pr, 5-F)</td><td>Ph(3-CF3, 5-OCHF2)</td>

<td>Ph(3-1-Bu, 5- c -Pr)</td><td>Ph(3- c -Pr, 5-Br)</td><td>Ph(3-CF3, 5-OCF2CF2H)</td>

<td>Ph(3-1-Bu, 5-CF3)</td><td>Ph(3- c -Pr, 5-I)</td><td>Ph(3-CF3, 5-OC2F5)</td>

<td>Ph(3-1-Bii, 5-CT.)</td><td>Ph(3- c -Pr, 5-Me)</td><td>Ph(3-CF3, 5-SO2Me)</td>

<td>Ph(3-1-Bu, 5-CF2CF2H)</td><td>Ph(3- c -Pr, 5-Et)</td><td>Ph(3-CF3,5-TMS)</td>

<td>Ph(3-1-Bu, 5-CF2H)</td><td>Ph(3-c-Pr, 5-n-Pr)</td><td>Ph(3-CF3,5-CN)</td>

<td>Ph(3-1-Bu, 5-OMe)</td><td>Ph(3- c -Pr, 5-1-Bu)</td><td>Ph(3-C2F5,5-Cl)</td>

<td>Ph(3-1-Bu, 5-OCF3)</td><td>Ph(3- c -Pr, 5- i -Pr)</td><td>Ph(3-C2F5,5-F)</td>

<td>Ph(3-1-Bu, 5-OCHF2)</td><td>Ph(3, 5-di-c-Pr)</td><td>Ph(3-C2F5,5-Br)</td>

<td>Ph(3-1-Bu, 5-OCF2CF2H)</td><td>Ph(3- c -Pr, 5-CF3)</td><td>Ph(3-C2F5,5-I)</td>

<td>Ph(3-1-Bii, 5-OCT.)</td><td>Ph(3- c -Pr, 5-C2F5)</td><td>Ph(3-C2F5,5-Me)</td>

<td>Ph(3-1-Bu, 5-SO2Me)</td><td>Ph(3- c -Pr, 5-CF2CF2H)</td><td>Ph(3-C2F5,5-Et)</td>

<td>Ph(3-1-Bu, 5-TMS)</td><td>Ph(3- c -Pr, 5-CF2H)</td><td>Ph(3-C2F5, 5-n-Pr)</td>

<td>Ph(3-1-Bu, 5-CN)</td><td>Ph(3- c -Pr, 5-OMe)</td><td>Ph(3-C2F5,5-1-Bu)</td>

<td>Ph(3- i -Pr, 5-Cl)</td><td>Ph(3- c -Pr, 5-OCF3)</td><td>Ph(3-C2F5, 5- i -Pr)</td>

<td>Ph(3- i -Pr, 5-F)</td><td>Ph(3- c -Pr, 5-OCHF2)</td><td>Ph(3-C2F5, 5- c -Pr)</td>

<td>Ph(3- i -Pr, 5-Br)</td><td>Ph(3- c -Pr, 5-OCF2CF2H)</td><td>Ph(3-C2FsCF3, 5-CF3)</td>

<td>Ph(3- i -Pr, 5-I)</td><td>Ph(3- c -Pr, 5-OC2F5)</td><td>Ph(3, 5-di-C2F5)</td>

<td>Ph(3- i -Pr, 5-Me)</td><td>Ph(3- c -Pr, 5-SO2Me)</td><td>Ph(3-C2F5, 5-CF2CF2H)</td>

<td>Ph(3- i -Pr, 5-Et)</td><td>Ph(3- c -Pr, 5-TMS)</td><td>Ph(3-C2F5,5-CF2H)</td>

<td>Ph(3-i-Pr, 5-n-Pr)</td><td>Ph(3- c -Pr, 5-CN)</td><td>Ph(3-C2F5, 5-OMe)</td>

<td>Ph(3- i -Pr, 5-1-Bu)</td><td>Ph(3-CF3,5-Cl)</td><td>Ph(3-C2F5, 5-OCF3)</td>

<td>Ph(3, 5-di-i-Pr)</td><td>Ph(3-CF3,5-F)</td><td>Ph(3-C2F5,5-OCHF2)</td>

<td>Ph(3- i -Pr, 5- c -Pr)</td><td>Ph(3-CF3,5-Br)</td><td>Ph(3-C2F5, 5-OCF2CF2H)</td>

<td>Ph(3- i -Pr, 5-CF3)</td><td>Ph(3-CF3,5-I)</td><td>Ph(3-C2F5, 5-OC2F5)</td>

<td>Ph(3- i -Pr, 5-C2F5)</td><td>Ph(3-CF3,5-Me)</td><td>Ph(3-C2F5, 5-SO2Me)</td>

<td>Ph(3- i -Pr, 5-CF2CF2H)</td><td>Ph(3-CF3, 5-Et)</td><td>Ph(3-C2F5,5-TMS)</td>

<td>Ph(3- i -Pr, 5-CF2H)</td><td>Ph(3-CF3, 5-n-Pr)</td><td>Ph(3-C2F5,5-CN)</td>

<td>Ph(3- i -Pr, 5-OMe)</td><td>Ph(3-CF3,5-1-Bu)</td><td>Ph(3-CF2CF2H, 5-Cl)</td>

<td>Ph(3- i -Pr, 5-OCF3)</td><td>Ph(3-CF3, 5- i -Pr)</td><td>Ph(3-CF2CF2H, 5-F)</td>

<td>Ph(3- i -Pr, 5-OCHF2)</td><td>Ph(3-CF3, 5-c-Pr)</td><td>Ph(3-CF2CF2H, 5-Br)</td>

<td>Ph(3- i -Pr, 5-OCF2CF2H)</td><td>Ph(3, 5-di-CF3)</td><td>Ph(3-CF2CF2H, 5-I)</td>

<td>Ph(3- i -Pr, 5-OC2F5)</td><td>Ph(3-CF3, 5-C2F5)</td><td>Ph(3-CF2CF2H, 5-Me)</td>

<td>Ph(3- i -Pr, 5-SO2Me)</td><td>Ph(3-CF3, 5-CF2CF2H)</td><td>Ph(3-CF2CF2H, 5-Et)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-CF2CF2H, 5-n-Pr)</td><td>Ph(3-CF2H,5-CN)</td><td>Ph(3-OCF3, 5-OMe)</td>

<td>Ph(3-CF2CF2H, 5-1-Bu)</td><td>Ph(3-OMe, 5-Cl)</td><td>Ph(3, 5-di-OCF3)</td>

<td>Ph(3-CF2CF2H, 5- i -Pr)</td><td>Ph(3-OMe, 5-F)</td><td>Ph(3-OCF3, 5-OCHF2)</td>

<td>Ph(3-CF2CF2H, 5- c -Pr)</td><td>Ph(3-OMe, 5-Br)</td><td>Ph(3-OCF3, 5-OCF2CF2H)</td>

<td>Ph(3-CF2CF2H, 5-CF3)</td><td>Ph(3-OMe, 5-I)</td><td>Ph(3-OCF3, 5-OC2F5)</td>

<td>Ph(3-CF2CF2H, 5-C2F5)</td><td>Ph(3-OMe, 5-Me)</td><td>Ph(3-OCF3, 5-SO2Me)</td>

<td>Ph(3, 5-di-CF2CF2H)</td><td>Ph(3-OMe, 5-Et)</td><td>Ph(3-OCF3, 5-TMS)</td>

<td>Ph(3-CF2CF2H, 5-CF2H)</td><td>Ph(3-OMe, 5-n-Pr)</td><td>Ph(3-OCF3,5-CN)</td>

<td>Ph(3-CF2CF2H, 5-OMe)</td><td>Ph(3-OMe, 5-1-Bu)</td><td>Ph(3-OCHF2,5-Cl)</td>

<td>Ph(3-CF2CF2H, 5-OCF3)</td><td>Ph(3-OMe, 5- i -Pr)</td><td>Ph(3-OCHF2,5-F)</td>

<td>Ph(3-CF2CF2H, 5-OCHF2)</td><td>Ph(3-OMe, 5- c -Pr)</td><td>Ph(3-OCHF2,5-Br)</td>

<td>Ph(3-CF2CF2H, 5-OCF2CF2H)</td><td>Ph(3-OMeCF3, 5-CF3)</td><td>Ph(3-OCHF2,5-I)</td>

<td>Ph(3-CF2CF2H, 5-OC2F5)</td><td>Ph(3-OMe, 5-C2F5)</td><td>Ph(3-OCHF2, 5-Me)</td>

<td>Ph(3-CF2CF2H, 5-SO2Me)</td><td>Ph(3-OMe, 5-CF2CF2H)</td><td>Ph(3-OCHF2, 5-Et)</td>

<td>Ph(3-CF2CF2H, 5-TMS)</td><td>Ph(3-OMe, 5-CF2H)</td><td>Ph(3-OCHF2, 5-n-Pr)</td>

<td>Ph(3-CF2CF2H, 5-CN)</td><td>Ph(3, 5-di-OMe)</td><td>Ph(3-OCHF2, 5-1-Bu)</td>

<td>Ph(3-CF2H,5-Cl)</td><td>Ph(3-OMe, 5-OCF3)</td><td>Ph(3-OCHF2, 5- i -Pr)</td>

<td>Ph(3-CF2H,5-F)</td><td>Ph(3-OMe, 5-OCHF2)</td><td>Ph(3-OCHF2, 5- c -Pr)</td>

<td>Ph(3-CF2H,5-Br)</td><td>Ph(3-OMe, 5-OCF2CF2H)</td><td>Ph(3-OCHF2CF3, 5-CF3)</td>

<td>Ph(3-CF2H,5-I)</td><td>Ph(3-OMe, 5-OC2F5)</td><td>Ph(3-OC2F5, 5-C2F5)</td>

<td>Ph(3-CF2H, 5-Me)</td><td>Ph(3-OMe, 5-SO2Me)</td><td>Ph(3-OCHF2, 5-CF2CF2H)</td>

<td>Ph(3-CF2H, 5-Et)</td><td>Ph(3-OMe, 5-TMS)</td><td>Ph(3-OCHF2, 5-CF2H)</td>

<td>Ph(3-CF2H, 5-n-Pr)</td><td>Ph(3-OMe, 5-CN)</td><td>Ph(3-OCHF2, 5-OMe)</td>

<td>Ph(3-CF2H,5-1-Bu)</td><td>Ph(3-OCF3, 5-Cl)</td><td>Ph(3-OCHF2, 5-OCF3)</td>

<td>Ph(3-CF2H, 5- i -Pr)</td><td>Ph(3-OCF3, 5-F)</td><td>Ph(3, 5-di-OCHF2)</td>

<td>Ph(3-CF2H, 5- c -Pr)</td><td>Ph(3-OCF3, 5-Br)</td><td>Ph(3-OCHF2, 5-OCF2CF2H)</td>

<td>Ph(3-CF2H, 5-CF3)</td><td>Ph(3-OCF3, 5-I)</td><td>Ph(3-OCHF2, 5-OC2F5)</td>

<td>Ph(3-CF2H,5-C2F5)</td><td>Ph(3-OCF3, 5-Me)</td><td>Ph(3-OCHF2, 5-SO2Me)</td>

<td>Ph(3-CF2H, 5-CF2CF2H)</td><td>Ph(3-OCF3, 5-Et)</td><td>Ph(3-OCHF2,5-TMS)</td>

<td>Ph(3,5-di-CF2H)</td><td>Ph(3-OCF3, 5-n-Pr)</td><td>Ph(3-OCHF2,5-CN)</td>

<td>Ph(3-CF2H, 5-OMe)</td><td>Ph(3-OCF3, 5-1-Bu)</td><td>Ph(3-OCF2CF2H, 5-Cl)</td>

<td>Ph(3-CF2H, 5-OCF3)</td><td>Ph(3-OCF3, 5- i -Pr)</td><td>Ph(3-OCF2CF2H, 5-F)</td>

<td>Ph(3-CF2H, 5-OCHF2)</td><td>Ph(3-OCF3, 5- c -Pr)</td><td>Ph(3-OCF2CF2H, 5-Br)</td>

<td>Ph(3-CF2H, 5-OCF2CF2H)</td><td>Ph(3-OCF3, 5-CF3)</td><td>Ph(3-OCF2CF2H, 5-I)</td>

<td>Ph(3-CF2H, 5-OC2F5)</td><td>Ph(3-OCF3, 5-C2F5)</td><td>Ph(3-OCF2CF2H, 5-Me)</td>

<td>Ph(3-CF2H, 5-SO2Me)</td><td>Ph(3-OCF3, 5-CF2CF2H)</td><td>Ph(3-OCF2CF2H, 5-Et)</td>

<td>Ph(3-CF2H, 5-TMS)</td><td>Ph(3-OCF3, 5-CF2H)</td><td>Ph(3-OCF2CF2H, 5-n-Pr)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(3-OCF2CF2H, 5-1-Bu)</td><td>Ph(3-SO2Me, 5-F)</td><td>Ph(3-TMS, 5-OCHF2)</td>

<td>Ph(3-OCF2CF2H, 5- i -Pr)</td><td>Ph(3-SO2Me, 5-Br)</td><td>Ph(3-TMS, 5-OCF2CF2H)</td>

<td>Ph(3-OCF2CF2H, 5- c -Pr)</td><td>Ph(3-SO2Me, 5-I)</td><td>Ph(3-TMS, 5-OC2F5)</td>

<td>Ph(3-OCF2CF2H, 5-CF3)</td><td>Ph(3-SO2Me, 5-Me)</td><td>Ph(3-TMS, 5-SO2Me)</td>

<td>Pli(3-OCT&lt;T;11, 5-CT.)</td><td>Ph(3-SO2Me, 5-Et)</td><td>Ph(3,5-di-TMS)</td>

<td>Ph(3-OCF2CF2H, 5-CF2CF2H)</td><td>Ph(3-SO2Me, 5-n-Pr)</td><td>Ph(3-TMS, 5-CN)</td>

<td>Ph(3-OCF2CF2H, 5-CF2H)</td><td>Ph(3-SO2Me, 5-1-Bu)</td><td>Ph(3-CN,5-Cl)</td>

<td>Ph(3-OCF2CF2H, 5-OMe)</td><td>Ph(3-SO2Me, 5- i -Pr)</td><td>Ph(3-CN,5-F)</td>

<td>Ph(3-OCF2CF2H, 5-OCF3)</td><td>Ph(3-SO2Me, 5- c -Pr)</td><td>Ph(3-CN,5-Br)</td>

<td>Ph(3-OCF2CF2H, 5-OCHF2)</td><td>Ph(3-SO2MeCF3, 5-CF3)</td><td>Ph(3-CN,5-I)</td>

<td>Ph(3, 5-di-OCF2CF2H)</td><td>Pli(3-SO;\le, 5-C;P4</td><td>Ph(3-CN,5-Me)</td>

<td>14i(3-OCT4T;l 1, 5-OCT.)</td><td>Ph(3-SO2Me, 5-CF2CF2H)</td><td>Ph(3-CN,5-Et)</td>

<td>Ph(3-OCF2CF2H, 5-SO2Me)</td><td>Ph(3-SO2Me, 5-CF2H)</td><td>Ph(3-CN, 5-n-Pr)</td>

<td>Ph(3-OCF2CF2H, 5-TMS)</td><td>Ph(3-SO2Me, 5-OMe)</td><td>Ph(3-CN,5-1-Bu)</td>

<td>Ph(3-OCF2CF2H, 5-CN)</td><td>Ph(3-SO2Me, 5-OCF3)</td><td>Ph(3-CN, 5- i -Pr)</td>

<td>Pli(3-OCT., 5-Cl)</td><td>Ph(3-SO2Me, 5-OCHF2)</td><td>Ph(3-CN, 5- c -Pr)</td>

<td>Ph(3-OC2F5,5-F)</td><td>Ph(3-SO2Me, 5-OCF2CF2H)</td><td>Ph(3-CN, 5-CF3)</td>

<td>Ph(3-OC2F5,5-Br)</td><td>Ph(3-SO2Me, 5-OC2F5)</td><td>Ph(3-CN, 5-C2F5)</td>

<td>Ph(3-OC2F5,5-I)</td><td>Ph(3, 5-di-SO2Me)</td><td>Ph(3-CN, 5-CF2CF2H)</td>

<td>Ph(3-OC2F5, 5-Me)</td><td>Ph(3-SO2Me, 5-TMS)</td><td>Ph(3-CN, 5-CF2H)</td>

<td>Ph(3-OC2F5, 5-Et)</td><td>Ph(3-SO2Me, 5-CN)</td><td>Ph(3-CN, 5-OMe)</td>

<td>Ph(3-OC2F5, 5-n-Pr)</td><td>Ph(3-TMS, 5-Cl)</td><td>Ph(3-CN, 5-OCF3)</td>

<td>Ph(3-OC2F5,5-1-Bu)</td><td>Ph(3-TMS, 5-F)</td><td>Ph(3-CN,5-OCHF2)</td>

<td>Ph(3-OC2F5, 5- i -Pr)</td><td>Ph(3-TMS, 5-Br)</td><td>Ph(3-CN, 5-OCF2CF2H)</td>

<td>Ph(3-OC2F5, 5-c -Pr)</td><td>Ph(3-TMS, 5-I)</td><td>Ph(3-CN, 5-OC2F5)</td>

<td>Pli(3-OC;P-.CP;, 5-CP;)</td><td>Ph(3-TMS, 5-Me)</td><td>Ph(3-CN, 5-SO2Me)</td>

<td>Pli(3-OC;P-., 5-CP;CP;l 1)</td><td>Ph(3-TMS, 5-Et)</td><td>Ph(3-CN,5-TMS)</td>

<td>Ph(3-OC2F5,5-CF2H)</td><td>Ph(3-TMS, 5-n-Pr)</td><td>Ph(3,5-di-CN)</td>

<td>Ph(3-OC2F5, 5-OMe)</td><td>Ph(3-TMS, 5-1-Bu)</td><td>Ph(2,3,4-tri-Cl)</td>

<td>Ph(3-OC2F5, 5-OCF3)</td><td>Ph(3-TMS, 5- i -Pr)</td><td>Ph(2-Cl, 3-Cl, 4-F)</td>

<td>Ph(3-OC2F5, 5-OCHF2)</td><td>Ph(3-TMS, 5- c -Pr)</td><td>Ph(2-Cl, 3-Cl, 4-Br)</td>

<td>Ph(3, 5-di-OC2F5)</td><td>Ph(3-TMS, 5-CF3)</td><td>Ph(2-Cl, 3-Cl, 4-I)</td>

<td>Ph(3, 5-di-OC2F5)</td><td>Ph(3-TMS, 5-C2F5)</td><td>Ph(2-Cl, 3-Cl, 4-Me)</td>

<td>Pli(3-OC;P-., 5-SO;\le)</td><td>Ph(3-TMS, 5-CF2CF2H)</td><td>Ph(2-Cl, 3-Cl, 4-Et)</td>

<td>Ph(3-OC2F5,5-TMS)</td><td>Ph(3-TMS, 5-CF2H)</td><td>Ph(2-Cl, 3-Cl, 4-n-Pr)</td>

<td>Ph(3-OC2F5,5-CN)</td><td>Ph(3-TMS, 5-OMe)</td><td>Ph(2-Cl, 3-Cl, 4-1-Bu)</td>

<td>Ph(3-SO2Me, 5-Cl)</td><td>Ph(3-TMS, 5-OCF3)</td><td>Ph(2-Cl, 3-Cl, 4- i -Pr)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-Cl, 4- c -Pr)</td><td>Ph(2-Cl, 3, 4-di-Br)</td><td>Ph(2-Cl, 3-I, 4-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-Cl, 4-CF3)</td><td>Ph(2-Cl, 3-Br, 4-I)</td><td>Ph(2-Cl, 3-I, 4-OC2F5)</td>

<td>Ph(2-Cl, 3-Cl, 4-C2F5)</td><td>Ph(2-Cl, 3-Br, 4-Me)</td><td>Ph(2-Cl, 3-I, 4-SO2Me)</td>

<td>Ph(2-Cl, 3-Cl, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-Br, 4-Et)</td><td>Ph(2-Cl, 3-I, 4-TMS)</td>

<td>Ph(2-Cl, 3-Cl, 4-CF2H)</td><td>Ph(2-Cl, 3-Br, 4-n-Pr)</td><td>Ph(2-Cl, 3-I, 4-CN)</td>

<td>Ph(2-Cl, 3-Cl, 4-OMe)</td><td>Ph(2-Cl, 3-Br, 4-1-Bu)</td><td>Ph(2-Cl, 3-Me, 4-Cl)</td>

<td>Ph(2-Cl, 3-Cl, 4-OCF3)</td><td>Ph(2-Cl, 3-Br, 4- i -Pr)</td><td>Ph(2-Cl, 3-Me, 4-F)</td>

<td>Ph(2-Cl, 3-Cl, 4-OCHF2)</td><td>Ph(2-Cl, 3-Br, 4- c -Pr)</td><td>Ph(2-Cl, 3-Me, 4-Br)</td>

<td>Ph(2-Cl, 3-Cl, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-Br, 4-CF3)</td><td>Ph(2-Cl, 3-Me, 4-I)</td>

<td>Ph(2-Cl, 3-Cl, 4-OC2F5)</td><td>Ph(2-Cl, 3-Br, 4-C2F5)</td><td>Ph(2-Cl, 3, 4-di-Me)</td>

<td>Ph(2-Cl, 3-Cl, 4-SO2Me)</td><td>Ph(2-Cl, 3-Br, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-Me, 4-Et)</td>

<td>Ph(2-Cl, 3-Cl, 4-TMS)</td><td>Ph(2-Cl, 3-Br, 4-CF2H)</td><td>Ph(2-Cl, 3-Me, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-Cl, 4-CN)</td><td>Ph(2-Cl, 3-Br, 4-OMe)</td><td>Ph(2-Cl, 3-Me, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-F, 4-Cl)</td><td>Ph(2-Cl, 3-Br, 4-OCF3)</td><td>Ph(2-Cl, 3-Me, 4- i -Pr)</td>

<td>Ph(2-Cl, 3, 4-di-F)</td><td>Ph(2-Cl, 3-Br, 4-OCHF2)</td><td>Ph(2-Cl, 3-Me, 4- c -Pr)</td>

<td>Ph(2-Cl, 3-F, 4-Br)</td><td>Ph(2-Cl, 3-Br, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-Me, 4-CF3)</td>

<td>Ph(2-Cl, 3-F, 4-I)</td><td>Ph(2-Cl, 3-Br, 4-OC2F5)</td><td>Ph(2-Cl, 3-Me, 4-C2F5)</td>

<td>Ph(2-Cl, 3-F, 4-Me)</td><td>Ph(2-Cl, 3-Br, 4-SO2Me)</td><td>Ph(2-Cl, 3-Me, 4-CF2CF2H)</td>

<td>Ph(2-Cl, 3-F, 4-Et)</td><td>Ph(2-Cl, 3-Br, 4-TMS)</td><td>Ph(2-Cl, 3-Me, 4-CF2H)</td>

<td>Ph(2-Cl, 3-F, 4-n-Pr)</td><td>Ph(2-Cl, 3-Br, 4-CN)</td><td>Ph(2-Cl, 3-Me, 4-OMe)</td>

<td>Ph(2-Cl, 3-F, 4-1-Bu)</td><td>Ph(2-Cl, 3-I, 4-Cl)</td><td>Ph(2-Cl, 3-Me, 4-OCF3)</td>

<td>Ph(2-Cl, 3-F, 4- i -Pr)</td><td>Ph(2-Cl, 3-I, 4-F)</td><td>Ph(2-Cl, 3-Me, 4-OCHF2)</td>

<td>Ph(2-Cl, 3-F, 4- c -Pr)</td><td>Ph(2-Cl, 3-I, 4-Br)</td><td>Ph(2-Cl, 3-Me, 4-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-F, 4-CF3)</td><td>Ph(2-Cl, 3, 4-di-I)</td><td>Ph(2-Cl, 3-Me, 4-OC2F5)</td>

<td>Ph(2-Cl, 3-F, 4-C2F5)</td><td>Ph(2-Cl, 3-I, 4-Me)</td><td>Ph(2-Cl, 3-Me, 4-SO2Me)</td>

<td>Ph(2-Cl, 3-F, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-I, 4-Et)</td><td>Ph(2-Cl, 3-Me, 4-TMS)</td>

<td>Ph(2-Cl, 3-F, 4-CF2H)</td><td>Ph(2-Cl, 3-I, 4-n-Pr)</td><td>Ph(2-Cl, 3-Me, 4-CN)</td>

<td>Ph(2-Cl, 3-F, 4-OMe)</td><td>Ph(2-Cl, 3-I, 4-1-Bu)</td><td>Ph(2-Cl, 3-Et, 4-Cl)</td>

<td>Ph(2-Cl, 3-F, 4-OCF3)</td><td>Ph(2-Cl, 3-I, 4- i -Pr)</td><td>Ph(2-Cl, 3-Et, 4-F)</td>

<td>Ph(2-Cl, 3-F, 4-OCHF2)</td><td>Ph(2-Cl, 3-I, 4- c -Pr)</td><td>Ph(2-Cl, 3-Et, 4-Br)</td>

<td>Ph(2-Cl, 3-F, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-I, 4-CF3)</td><td>Ph(2-Cl, 3-Et, 4-I)</td>

<td>Ph(2-Cl, 3-F, 4-OC2F5)</td><td>Ph(2-Cl, 3-I, 4-C2F5)</td><td>Ph(2-Cl, 3-Et, 4-Me)</td>

<td>Ph(2-Cl, 3-F, 4-SO2Me)</td><td>Ph(2-Cl, 3-I, 4-CF2CF2H)</td><td>Ph(2-Cl, 3, 4-di-Et)</td>

<td>Ph(2-Cl, 3-F, 4-TMS)</td><td>Ph(2-Cl, 3-I, 4-CF2H)</td><td>Ph(2-Cl, 3-Et, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-F, 4-CN)</td><td>Ph(2-Cl, 3-I, 4-OMe)</td><td>Ph(2-Cl, 3-Et, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-Br, 4-Cl)</td><td>Ph(2-Cl, 3-I, 4-OCF3)</td><td>Ph(2-Cl, 3-Et, 4- i -Pr)</td>

<td>Ph(2-Cl, 3-Br, 4-F)</td><td>Ph(2-Cl, 3-I, 4-OCHF2)</td><td>Ph(2-Cl, 3-Et, 4- c -Pr)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>49 Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-Et, 4-CF3)</td><td>Ph(2-Cl, 3-1-Bu, 4-I)</td><td>Ph(2-Cl, 3- i -Pr, 4-OC2F5)</td>

<td>Ph(2-Cl, 3-Et, 4-C2F5)</td><td>Ph(2-Cl, 3-1-Bu, 4-Me)</td><td>Ph(2-Cl, 3- i -Pr, 4-SO2Me)</td>

<td>Ph(2-Cl, 3-Et, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-1-Bu, 4-Et)</td><td>Ph(2-Cl, 3- i -Pr, 4-TMS)</td>

<td>Ph(2-Cl, 3-Et, 4-CF2H)</td><td>Ph(2-Cl, 3-1-Bu, 4-n-Pr)</td><td>Ph(2-Cl, 3- i -Pr, 4-CN)</td>

<td>Ph(2-Cl, 3-Et, 4-OMe)</td><td>Ph(2-Cl, 3, 4-di-1-Bu)</td><td>Ph(2-Cl, 3- c -Pr, 4-Cl)</td>

<td>Ph(2-Cl, 3-Et, 4-OCF3)</td><td>Ph(2-Cl, 3-1-Bu, 4- i -Pr)</td><td>Ph(2-Cl, 3- c -Pr, 4-F)</td>

<td>Ph(2-Cl, 3-Et, 4-OCHF2)</td><td>Ph(2-Cl, 3-1-Bu, 4- c -Pr)</td><td>Ph(2-Cl, 3- c -Pr, 4-Br)</td>

<td>Ph(2-Cl, 3-Et, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-1-Bu, 4-CF3)</td><td>Ph(2-Cl, 3- c -Pr, 4-I)</td>

<td>Ph(2-Cl, 3-Et, 4-OC2F5)</td><td>Ph(2-Cl, 3-1-Bu, 4-C2F5)</td><td>Ph(2-Cl, 3- c -Pr, 4-Me)</td>

<td>Ph(2-Cl, 3-Et, 4-SO2Me)</td><td>Ph(2-Cl, 3-1-Bu, 4-CF2CF2H)</td><td>Ph(2-Cl, 3- c -Pr, 4-Et)</td>

<td>Ph(2-Cl, 3-Et, 4-TMS)</td><td>Ph(2-Cl, 3-1-Bu, 4-CF2H)</td><td>Ph(2-Cl, 3-c-Pr, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-Et, 4-CN)</td><td>Ph(2-Cl, 3-1-Bu, 4-OMe)</td><td>Ph(2-Cl, 3- c -Pr, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-Cl)</td><td>Ph(2-Cl, 3-1-Bu, 4-OCF3)</td><td>Ph(2-Cl, 3- c -Pr, 4- i -Pr)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-F)</td><td>Ph(2-Cl, 3-1-Bu, 4-OCHF2)</td><td>Ph(2-Cl, 3, 4-di- c -Pr)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-Br)</td><td>Ph(2-Cl, 3-1-Bu, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3- c -Pr, 4-CF3)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-I)</td><td>Ph(2-Cl, 3-1-Bu, 4-OC2F5)</td><td>Ph(2-Cl, 3- c -Pr, 4-C2F5)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-Me)</td><td>Ph(2-Cl, 3-1-Bu, 4-SO2Me)</td><td>Ph(2-Cl, 3- c -Pr, 4-CF2CF2H)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-Et)</td><td>Ph(2-Cl, 3-1-Bu, 4-TMS)</td><td>Ph(2-Cl, 3- c -Pr, 4-CF2H)</td>

<td>Ph(2-Cl, 3, 4-di-n-Pr)</td><td>Ph(2-Cl, 3-1-Bu, 4-CN)</td><td>Ph(2-Cl, 3- c -Pr, 4-OMe)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-1-Bu)</td><td>Ph(2-Cl, 3- i -Pr, 4-Cl)</td><td>Ph(2-Cl, 3- c -Pr, 4-OCF3)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-i-Pr)</td><td>Ph(2-Cl, 3- i -Pr, 4-F)</td><td>Ph(2-Cl, 3- c -Pr, 4-OCHF2)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-c-Pr)</td><td>Ph(2-Cl, 3- i -Pr, 4-Br)</td><td>Ph(2-Cl, 3- c -Pr, 4-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-CF3)</td><td>Ph(2-Cl, 3- i -Pr, 4-I)</td><td>Ph(2-Cl, 3- c -Pr, 4-OC2F5)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-C2F5)</td><td>Ph(2-Cl, 3- i -Pr, 4-Me)</td><td>Ph(2-Cl, 3- c -Pr, 4-SO2Me)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-CF2CF2H)</td><td>Ph(2-Cl, 3- i -Pr, 4-Et)</td><td>Ph(2-Cl, 3- c -Pr, 4-TMS)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-CF2H)</td><td>Ph(2-Cl, 3- i -Pr, 4-n-Pr)</td><td>Ph(2-Cl, 3- c -Pr, 4-CN)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-OMe)</td><td>Ph(2-Cl, 3- i -Pr, 4-1-Bu)</td><td>Ph(2-Cl, 3-CF3, 4-Cl)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-OCF3)</td><td>Ph(2-Cl, 3, 4-di-i-Pr)</td><td>Ph(2-Cl, 3-CF3, 4-F)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-OCHF2)</td><td>Ph(2-Cl, 3- i -Pr, 4- c -Pr)</td><td>Ph(2-Cl, 3-CF3, 4-Br)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3- i -Pr, 4-CF3)</td><td>Ph(2-Cl, 3-CF3, 4-I)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-OC2F5)</td><td>Ph(2-Cl, 3- i -Pr, 4-C2F5)</td><td>Ph(2-Cl, 3-CF3, 4-Me)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-SO2Me)</td><td>Ph(2-Cl, 3- i -Pr, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-CF3, 4-Et)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-TMS)</td><td>Ph(2-Cl, 3- i -Pr, 4-CF2H)</td><td>Ph(2-Cl, 3-CF3, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-n-Pr, 4-CN)</td><td>Ph(2-Cl, 3- i -Pr, 4-OMe)</td><td>Ph(2-Cl, 3-CF3, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-1-Bu, 4-Cl)</td><td>Ph(2-Cl, 3- i -Pr, 4-OCF3)</td><td>Ph(2-Cl, 3-CF3, 4- i -Pr)</td>

<td>Ph(2-Cl, 3-1-Bu, 4-F)</td><td>Ph(2-Cl, 3- i -Pr, 4-OCHF2)</td><td>Ph(2-Cl, 3-CF3, 4- c -Pr)</td>

<td>Ph(2-Cl, 3-1-Bu, 4-Br)</td><td>Ph(2-Cl, 3- i -Pr, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3, 4-di-CF3)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-CF3, 4-C2F5)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-Me)</td><td>Ph(2-Cl, 3-CF2H, 4-SO2Me)</td>

<td>Ph(2-Cl, 3-CF3, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-Et)</td><td>Ph(2-Cl, 3-CF2H, 4-TMS)</td>

<td>Ph(2-Cl, 3-CF3, 4-CF2H)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-n-Pr)</td><td>Ph(2-Cl, 3-CF2H, 4-CN)</td>

<td>Ph(2-Cl, 3-CF3, 4-OMe)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-1-Bu)</td><td>Ph(2-Cl, 3-OMe, 4-Cl)</td>

<td>Ph(2-Cl, 3-CF3, 4-OCF3)</td><td>Ph(2-Cl, 3-CF2CF2H, 4- i -Pr)</td><td>Ph(2-Cl, 3-OMe, 4-F)</td>

<td>Ph(2-Cl, 3-CF3, 4-OCHF2)</td><td>Ph(2-Cl, 3-CF2CF2H, 4- c -Pr)</td><td>Ph(2-Cl, 3-OMe, 4-Br)</td>

<td>Ph(2-Cl, 3-CF3, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-CF3)</td><td>Ph(2-Cl, 3-OMe, 4-I)</td>

<td>Ph(2-Cl, 3-CF3, 4-OC2F5)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-C2F5)</td><td>Ph(2-Cl, 3-OMe, 4-Me)</td>

<td>Ph(2-Cl, 3-CF3, 4-SO2Me)</td><td>Ph(2-Cl, 3, 4-di-CF2CF2H)</td><td>Ph(2-Cl, 3-OMe, 4-Et)</td>

<td>Ph(2-Cl, 3-CF3, 4-TMS)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-CF2H)</td><td>Ph(2-Cl, 3-OMe, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-CF3, 4-CN)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-OMe)</td><td>Ph(2-Cl, 3-OMe, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-C2F5, 4-Cl)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-OCF3)</td><td>Ph(2-Cl, 3-OMe, 4- i -Pr)</td>

<td>Ph(2-Cl, 3-C2F5, 4-F)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-OCHF2)</td><td>Ph(2-Cl, 3-OMe, 4- c -Pr)</td>

<td>Ph(2-Cl, 3-C2F5, 4-Br)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-OMe, 4-CF3)</td>

<td>Ph(2-Cl, 3-C2F5, 4-I)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-OC2F5)</td><td>Ph(2-Cl, 3-OMe, 4-C2F5)</td>

<td>Ph(2-Cl, 3-C2F5, 4-Me)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-SO2Me)</td><td>Ph(2-Cl, 3-OMe, 4-CF2CF2H)</td>

<td>Ph(2-Cl, 3-C2F5, 4-Et)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-TMS)</td><td>Ph(2-Cl, 3-OMe, 4-CF2H)</td>

<td>Ph(2-Cl, 3-C2F5, 4-n-Pr)</td><td>Ph(2-Cl, 3-CF2CF2H, 4-CN)</td><td>Ph(2-Cl, 3, 4-di-OMe)</td>

<td>Ph(2-Cl, 3-C2F5, 4-1-Bu)</td><td>Ph(2-Cl, 3-CF2H, 4-Cl)</td><td>Ph(2-Cl, 3-OMe, 4-OCF3)</td>

<td>Ph(2-Cl, 3-C2F5, 4- i -Pr)</td><td>Ph(2-Cl, 3-CF2H, 4-F)</td><td>Ph(2-Cl, 3-OMe, 4-OCHF2)</td>

<td>Ph(2-Cl, 3-C2F5, 4- c -Pr)</td><td>Ph(2-Cl, 3-CF2H, 4-Br)</td><td>Ph(2-Cl, 3-OMe, 4-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-C2F5CF3, 4-CF3)</td><td>Ph(2-Cl, 3-CF2H, 4-I)</td><td>Ph(2-Cl, 3-OMe, 4-OC2F5)</td>

<td>Ph(2-Cl, 3, 4-di-C2F5)</td><td>Ph(2-Cl, 3-CF2H, 4-Me)</td><td>Ph(2-Cl, 3-OMe, 4-SO2Me)</td>

<td>Ph(2-Cl, 3-C2F5, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-CF2H, 4-Et)</td><td>Ph(2-Cl, 3-OMe, 4-TMS)</td>

<td>Ph(2-Cl, 3-C2F5, 4-CF2H)</td><td>Ph(2-Cl, 3-CF2H, 4-n-Pr)</td><td>Ph(2-Cl, 3-OMe, 4-CN)</td>

<td>Ph(2-Cl, 3-C2F5, 4-OMe)</td><td>Ph(2-Cl, 3-CF2H, 4-1-Bu)</td><td>Ph(2-Cl, 3-OCF3, 4-Cl)</td>

<td>Ph(2-Cl, 3-C2F5, 4-OCF3)</td><td>Ph(2-Cl, 3-CF2H, 4- i -Pr)</td><td>Ph(2-Cl, 3-OCF3, 4-F)</td>

<td>Ph(2-Cl, 3-C2F5, 4-OCHF2)</td><td>Ph(2-Cl, 3-CF2H, 4- c -Pr)</td><td>Ph(2-Cl, 3-OCF3, 4-Br)</td>

<td>Ph(2-Cl, 3-C2F5, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-CF2H, 4-CF3)</td><td>Ph(2-Cl, 3-OCF3, 4-I)</td>

<td>Ph(2-Cl, 3-C2F5, 4-OC2F5)</td><td>Ph(2-Cl, 3-CF2H, 4-C2F5)</td><td>Ph(2-Cl, 3-OCF3, 4-Me)</td>

<td>Ph(2-Cl, 3-C2F5, 4-SO2Me)</td><td>Ph(2-Cl, 3-CF2H, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-OCF3, 4-Et)</td>

<td>Ph(2-Cl, 3-C2F5, 4-TMS)</td><td>Ph(2-Cl, 3, 4-di-CF2H)</td><td>Ph(2-Cl, 3-OCF3, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-C2F5, 4-CN)</td><td>Ph(2-Cl, 3-CF2H, 4-OMe)</td><td>Ph(2-Cl, 3-OCF3, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-CF2CF2H, 4-Cl)</td><td>Ph(2-Cl, 3-CF2H, 4-OCF3)</td><td>Ph(2-Cl, 3-OCF3, 4- i -Pr)</td>

<td>Ph(2-Cl, 3-CF2CF2H, 4-F)</td><td>Ph(2-Cl, 3-CF2H, 4-OCHF2)</td><td>Ph(2-Cl, 3-OCF3, 4- c -Pr)</td>

<td>Ph(2-Cl, 3-CF2CF2H, 4-Br)</td><td>Ph(2-Cl, 3-CF2H, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-OCF3, 4-CF3)</td>

<td>Ph(2-Cl, 3-CF2CF2H, 4-I)</td><td>Ph(2-Cl, 3-CF2H, 4-OC2F5)</td><td>Ph(2-Cl, 3-OCF3, 4-C2F5)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>51 Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-OCF3, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-Et)</td><td>Ph(2-Cl, 3-OC2F5, 4-CN)</td>

<td>Ph(2-Cl, 3-OCF3, 4-CF2H)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-n-Pr)</td><td>Ph(2-Cl, 3-SO2Me, 4-Cl)</td>

<td>Ph(2-Cl, 3-OCF3, 4-OMe)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-t-Bu)</td><td>Ph(2-Cl, 3-SO2Me, 4-F)</td>

<td>Ph(2-Cl, 3, 4-di-OCF3)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-i -Pr)</td><td>Ph(2-Cl, 3-SO2Me, 4-Br)</td>

<td>Ph(2-Cl, 3-OCF3, 4-OCHF2)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-c -Pr)</td><td>Ph(2-Cl, 3-SO2Me, 4-I)</td>

<td>Ph(2-Cl, 3-OCF3, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-CF3)</td><td>Ph(2-Cl, 3-SO2Me, 4-Me)</td>

<td>Ph(2-Cl, 3-OCF3, 4-OC2F5)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-C2F5)</td><td>Ph(2-Cl, 3-SO2Me, 4-Et)</td>

<td>Ph(2-Cl, 3-OCF3, 4-SO2Me)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-SO2Me, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-OCF3, 4-TMS)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-CF2H)</td><td>Ph(2-Cl, 3-SO2Me, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-OCF3, 4-CN)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-OMe)</td><td>Ph(2-Cl, 3-SO2Me, 4- i -Pr)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-Cl)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-OCF3)</td><td>Ph(2-Cl, 3-SO2Me, 4- c -Pr)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-F)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-OCHF2)</td><td>Ph(2-Cl, 3-SO2MeCF3, 4-CF3)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-Br)</td><td>Ph(2-Cl, 3, 4-di-OCF2CF2H)</td><td>Ph(2-Cl, 3-SO2Me, 4-C2F5)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-I)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-OC2F5)</td><td>Ph(2-Cl, 3-SO2Me, 4-CF2CF2H)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-Me)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-SO2Me)</td><td>Ph(2-Cl, 3-SO2Me, 4-CF2H)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-Et)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-TMS)</td><td>Ph(2-Cl, 3-SO2Me, 4-OMe)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-n-Pr)</td><td>Ph(2-Cl, 3-OCF2CF2H, 4-CN)</td><td>Ph(2-Cl, 3-SO2Me, 4-OCF3)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-1-Bu)</td><td>Ph(2-Cl, 3-OC2F5, 4-Cl)</td><td>Ph(2-Cl, 3-SO2Me, 4-OCHF2)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-i -Pr)</td><td>Ph(2-Cl, 3-OC2F5, 4-F)</td><td>Ph(2-Cl, 3-SO2Me, 4-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-OCHF2, 4- c -Pr)</td><td>Ph(2-Cl, 3-OC2F5, 4-Br)</td><td>Ph(2-Cl, 3-SO2Me, 4-OC2F5)</td>

<td>Ph(2-Cl, 3-OCHF2CF3, 4-CF3)</td><td>Ph(2-Cl, 3-OC2F5, 4-I)</td><td>Ph(2-Cl, 3, 4-di-SO2Me)</td>

<td>Ph(2-Cl, 3-OC2F5, 4-C2F5)</td><td>Ph(2-Cl, 3-OC2F5, 4-Me)</td><td>Ph(2-Cl, 3-SO2Me, 4-TMS)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-OC2F5, 4-Et)</td><td>Ph(2-Cl, 3-SO2Me, 4-CN)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-CF2H)</td><td>Ph(2-Cl, 3-OC2F5, 4-n-Pr)</td><td>Ph(2-Cl, 3-TMS, 4-Cl)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-OMe)</td><td>Ph(2-Cl, 3-OC2F5, 4-1-Bu)</td><td>Ph(2-Cl, 3-TMS, 4-F)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-OCF3)</td><td>Ph(2-Cl, 3-OC2F5, 4- i -Pr)</td><td>Ph(2-Cl, 3-TMS, 4-Br)</td>

<td>Ph(2-Cl, 3, 4-di-OCHF2)</td><td>Ph(2-Cl, 3-OC2F5, 4- c -Pr)</td><td>Ph(2-Cl, 3-TMS, 4-I)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-OC2F5CF3, 4-CF3)</td><td>Ph(2-Cl, 3-TMS, 4-Me)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-OC2F5)</td><td>Ph(2-Cl, 3-OC2F5, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-TMS, 4-Et)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-SO2Me)</td><td>Ph(2-Cl, 3-OC2F5, 4-CF2H)</td><td>Ph(2-Cl, 3-TMS, 4-n-Pr)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-TMS)</td><td>Ph(2-Cl, 3-OC2F5, 4-OMe)</td><td>Ph(2-Cl, 3-TMS, 4-1-Bu)</td>

<td>Ph(2-Cl, 3-OCHF2, 4-CN)</td><td>Ph(2-Cl, 3-OC2F5, 4-OCF3)</td><td>Ph(2-Cl, 3-TMS, 4- i -Pr)</td>

<td>Ph(2-Cl, 3-OCF2CF2H, 4-Cl)</td><td>Ph(2-Cl, 3-OC2F5, 4-OCHF2)</td><td>Ph(2-Cl, 3-TMS, 4- c -Pr)</td>

<td>Ph(2-Cl, 3-OCF2CF2H, 4-F)</td><td>Ph(2-Cl, 3-OC2F5, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-TMS, 4-CF3)</td>

<td>Ph(2-Cl, 3-OCF2CF2H, 4-Br)</td><td>Ph(2-Cl, 3, 4-di-OC2F5)</td><td>Ph(2-Cl, 3-TMS, 4-C2F5)</td>

<td>Ph(2-Cl, 3-OCF2CF2H, 4-I)</td><td>Ph(2-Cl, 3-OC2F5, 4-SO2Me)</td><td>Ph(2-Cl, 3-TMS, 4-CF2CF2H)</td>

<td>Ph(2-Cl, 3-OCF2CF2H, 4-Me)</td><td>Ph(2-Cl, 3-OC2F5, 4-TMS)</td><td>Ph(2-Cl, 3-TMS, 4-CF2H)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-TMS, 4-OMe)</td><td>Ph(2-Cl, 3-Cl, 5-1-Bu)</td><td>Ph(2-Cl, 3-Br, 5-Cl)</td>

<td>Ph(2-Cl, 3-TMS, 4-OCF3)</td><td>Ph(2-Cl, 3-Cl, 5- i -Pr)</td><td>Ph(2-Cl, 3-Br, 5-F)</td>

<td>Ph(2-Cl, 3-TMS, 4-OCHF2)</td><td>Ph(2-Cl, 3-Cl, 5- c -Pr)</td><td>Ph(2-Cl, 3, 5-di-Br)</td>

<td>Ph(2-Cl, 3-TMS, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-Cl, 5-CF3)</td><td>Ph(2-Cl, 3-Br, 5-I)</td>

<td>Ph(2-Cl, 3-TMS, 4-OC2F5)</td><td>Ph(2-Cl, 3-Cl, 5-C2F5)</td><td>Ph(2-Cl, 3-Br, 5-Me)</td>

<td>Ph(2-Cl, 3-TMS, 4-SO2Me)</td><td>Ph(2-Cl, 3-Cl, 5-CF2CF2H)</td><td>Ph(2-Cl, 3-Br, 5-Et)</td>

<td>Ph(2-Cl, 3, 4-di-TMS)</td><td>Ph(2-Cl, 3-Cl, 5-CF2H)</td><td>Ph(2-Cl, 3-Br, 5-n-Pr)</td>

<td>Ph(2-Cl, 3-TMS, 4-CN)</td><td>Ph(2-Cl, 3-Cl, 5-OMe)</td><td>Ph(2-Cl, 3-Br, 5-1-Bu)</td>

<td>Ph(2-Cl, 3-CN, 4-Cl)</td><td>Ph(2-Cl, 3-Cl, 5-OCF3)</td><td>Ph(2-Cl, 3-Br, 5- i -Pr)</td>

<td>Ph(2-Cl, 3-CN, 4-F)</td><td>Ph(2-Cl, 3-Cl, 5-OCHF2)</td><td>Ph(2-Cl, 3-Br, 5- c -Pr)</td>

<td>Ph(2-Cl, 3-CN, 4-Br)</td><td>Ph(2-Cl, 3-Cl, 5-OCF2CF2H)</td><td>Ph(2-Cl, 3-Br, 5-CF3)</td>

<td>Ph(2-Cl, 3-CN, 4-I)</td><td>Ph(2-Cl, 3-Cl, 5-OC2F5)</td><td>Ph(2-Cl, 3-Br, 5-C2F5)</td>

<td>Ph(2-Cl, 3-CN, 4-Me)</td><td>Ph(2-Cl, 3-Cl, 5-SO2Me)</td><td>Ph(2-Cl, 3-Br, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 3-CN, 4-Et)</td><td>Ph(2-Cl, 3-Cl, 5-TMS)</td><td>Ph(2-Cl, 3-Br, 5-CF2H)</td>

<td>Ph(2-Cl, 3-CN, 4-n-Pr)</td><td>Ph(2-Cl, 3-Cl, 5-CN)</td><td>Ph(2-Cl, 3-Br, 5-OMe)</td>

<td>Ph(2-Cl, 3-CN, 4-1-Bu)</td><td>Ph(2-Cl, 3-F, 5-Cl)</td><td>Ph(2-Cl, 3-Br, 5-OCF3)</td>

<td>Ph(2-Cl, 3-CN, 4- i -Pr)</td><td>Ph(2-Cl, 3, 5-di-F)</td><td>Ph(2-Cl, 3-Br, 5-OCHF2)</td>

<td>Ph(2-Cl, 3-CN, 4- c -Pr)</td><td>Ph(2-Cl, 3-F, 5-Br)</td><td>Ph(2-Cl, 3-Br, 5-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-CN, 4-CF3)</td><td>Ph(2-Cl, 3-F, 5-I)</td><td>Ph(2-Cl, 3-Br, 5-OC2F5)</td>

<td>Ph(2-Cl, 3-CN, 4-C2F5)</td><td>Ph(2-Cl, 3-F, 5-Me)</td><td>Ph(2-Cl, 3-Br, 5-SO2Me)</td>

<td>Ph(2-Cl, 3-CN, 4-CF2CF2H)</td><td>Ph(2-Cl, 3-F, 5-Et)</td><td>Ph(2-Cl, 3-Br, 5-TMS)</td>

<td>Ph(2-Cl, 3-CN, 4-CF2H)</td><td>Ph(2-Cl, 3-F, 5-n-Pr)</td><td>Ph(2-Cl, 3-Br, 5-CN)</td>

<td>Ph(2-Cl, 3-CN, 4-OMe)</td><td>Ph(2-Cl, 3-F, 5-1-Bu)</td><td>Ph(2-Cl, 3-I, 5-Cl)</td>

<td>Ph(2-Cl, 3-CN, 4-OCF3)</td><td>Ph(2-Cl, 3-F, 5- i -Pr)</td><td>Ph(2-Cl, 3-I, 5-F)</td>

<td>Ph(2-Cl, 3-CN, 4-OCHF2)</td><td>Ph(2-Cl, 3-F, 5- c -Pr)</td><td>Ph(2-Cl, 3-I, 5-Br)</td>

<td>Ph(2-Cl, 3-CN, 4-OCF2CF2H)</td><td>Ph(2-Cl, 3-F, 5-CF3)</td><td>Ph(2-Cl, 3, 5-di-I)</td>

<td>Ph(2-Cl, 3-CN, 4-OC2F5)</td><td>Ph(2-Cl, 3-F, 5-C2F5)</td><td>Ph(2-Cl, 3-I, 5-Me)</td>

<td>Ph(2-Cl, 3-CN, 4-SO2Me)</td><td>Ph(2-Cl, 3-F, 5-CF2CF2H)</td><td>Ph(2-Cl, 3-I, 5-Et)</td>

<td>Ph(2-Cl, 3-CN, 4-TMS)</td><td>Ph(2-Cl, 3-F, 5-CF2H)</td><td>Ph(2-Cl, 3-I, 5-n-Pr)</td>

<td>Ph(2-Cl, 3, 4-di-CN)</td><td>Ph(2-Cl, 3-F, 5-OMe)</td><td>Ph(2-Cl, 3-I, 5-1-Bu)</td>

<td>Ph(2,3,5-tri-Cl)</td><td>Ph(2-Cl, 3-F, 5-OCF3)</td><td>Ph(2-Cl, 3-I, 5- i -Pr)</td>

<td>Ph(2-Cl, 3-Cl, 5-F)</td><td>Ph(2-Cl, 3-F, 5-OCHF2)</td><td>Ph(2-Cl, 3-I, 5- c -Pr)</td>

<td>Ph(2-Cl, 3-Cl, 5-Br)</td><td>Ph(2-Cl, 3-F, 5-OCF2CF2H)</td><td>Ph(2-Cl, 3-I, 5-CF3)</td>

<td>Ph(2-Cl, 3-Cl, 5-I)</td><td>Ph(2-Cl, 3-F, 5-OC2F5)</td><td>Ph(2-Cl, 3-I, 5-C2F5)</td>

<td>Ph(2-Cl, 3-Cl, 5-Me)</td><td>Ph(2-Cl, 3-F, 5-SO2Me)</td><td>Ph(2-Cl, 3-I, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 3-Cl, 5-Et)</td><td>Ph(2-Cl, 3-F, 5-TMS)</td><td>Ph(2-Cl, 3-I, 5-CF2H)</td>

<td>Ph(2-Cl, 3-Cl, 5-n-Pr)</td><td>Ph(2-Cl, 3-F, 5-CN)</td><td>Ph(2-Cl, 3-I, 5-OMe)</td>

MD 4889 B1 2024.03.31

<td rowspan="2">Q¹</td><td colspan="2"> 53</td>

<td>Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-I, 5-OCF3)</td><td>Ph(2-Cl, 3-Et, 5- i -Pr)</td><td>Ph(2-Cl, 3-1-Bu, 5-F)</td>

<td>Ph(2-Cl, 3-I, 5-OCHF2)</td><td>Ph(2-Cl, 3-Et, 5- c -Pr)</td><td>Ph(2-Cl, 3-1-Bu, 5-Br)</td>

<td>Ph(2-Cl, 3-I, 5-OCF2CF2H)</td><td>Ph(2-Cl, 3-Et, 5-CF3)</td><td>Ph(2-Cl, 3-1-Bu, 5-I)</td>

<td>Ph(2-Cl, 3-I, 5-OC2F5)</td><td>Ph(2-Cl, 3-Et, 5-C2F5)</td><td>Ph(2-Cl, 3-1-Bu, 5-Me)</td>

<td>Ph(2-Cl, 3-I, 5-SO2Me)</td><td>Ph(2-Cl, 3-Et, 5-CF2CF2H)</td><td>Ph(2-Cl, 3-1-Bu, 5-Et)</td>

<td>Ph(2-Cl, 3-I, 5-TMS)</td><td>Ph(2-Cl, 3-Et, 5-CF2H)</td><td>Ph(2-Cl, 3-1-Bu, 5-n-Pr)</td>

<td>Ph(2-Cl, 3-I, 5-CN)</td><td>Ph(2-Cl, 3-Et, 5-OMe)</td><td>Ph(2-Cl, 3, 5-di-1-Bu)</td>

<td>Ph(2-Cl, 3-Me, 5-Cl)</td><td>Ph(2-Cl, 3-Et, 5-OCF3)</td><td>Ph(2-Cl, 3-1-Bu, 5- i -Pr)</td>

<td>Ph(2-Cl, 3-Me, 5-F)</td><td>Ph(2-Cl, 3-Et, 5-OCHF2)</td><td>Ph(2-Cl, 3-1-Bu, 5- c -Pr)</td>

<td>Ph(2-Cl, 3-Me, 5-Br)</td><td>Ph(2-Cl, 3-Et, 5-OCF2CF2H)</td><td>Ph(2-Cl, 3-1-Bu, 5-CF3)</td>

<td>Ph(2-Cl, 3-Me, 5-I)</td><td>Ph(2-Cl, 3-Et, 5-OC2F5)</td><td>Ph(2-Cl, 3-1-Bu, 5-C2F5)</td>

<td>Ph(2-Cl, 3, 5-di-Me)</td><td>Ph(2-Cl, 3-Et, 5-SO2Me)</td><td>Ph(2-Cl, 3-1-Bu, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 3-Me, 5-Et)</td><td>Ph(2-Cl, 3-Et, 5-TMS)</td><td>Ph(2-Cl, 3-1-Bu, 5-CF2H)</td>

<td>Ph(2-Cl, 3-Me, 5-n-Pr)</td><td>Ph(2-Cl, 3-Et, 5-CN)</td><td>Ph(2-Cl, 3-1-Bu, 5-OMe)</td>

<td>Ph(2-Cl, 3-Me, 5-1-Bu)</td><td>Ph(2-Cl, 3-n-Pr, 5-Cl)</td><td>Ph(2-Cl, 3-1-Bu, 5-OCF3)</td>

<td>Ph(2-Cl, 3-Me, 5- i -Pr)</td><td>Ph(2-Cl, 3-n-Pr, 5-F)</td><td>Ph(2-Cl, 3-1-Bu, 5-OCHF2)</td>

<td>Ph(2-Cl, 3-Me, 5- c -Pr)</td><td>Ph(2-Cl, 3-n-Pr, 5-Br)</td><td>Ph(2-Cl, 3-1-Bu, 5-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-Me, 5-CF3)</td><td>Ph(2-Cl, 3-n-Pr, 5-I)</td><td>Ph(2-Cl, 3-1-Bu, 5-OC2F5)</td>

<td>Ph(2-Cl, 3-Me, 5-C2F5)</td><td>Ph(2-Cl, 3-n-Pr, 5-Me)</td><td>Ph(2-Cl, 3-1-Bu, 5-SO2Me)</td>

<td>Ph(2-Cl, 3-Me, 5-CF2CF2H)</td><td>Ph(2-Cl, 3-n-Pr, 5-Et)</td><td>Ph(2-Cl, 3-1-Bu, 5-TMS)</td>

<td>Ph(2-Cl, 3-Me, 5-CF2H)</td><td>Ph(2-Cl, 3, 5-di-n-Pr)</td><td>Ph(2-Cl, 3-1-Bu, 5-CN)</td>

<td>Ph(2-Cl, 3-Me, 5-OMe)</td><td>Ph(2-Cl, 3-n-Pr, 5-t-Bu)</td><td>Ph(2-Cl, 3- i -Pr, 5-Cl)</td>

<td>Ph(2-Cl, 3-Me, 5-OCF3)</td><td>Ph(2-Cl, 3-n-Pr, 5-i-Pr)</td><td>Ph(2-Cl, 3- i -Pr, 5-F)</td>

<td>Ph(2-Cl, 3-Me, 5-OCHF2)</td><td>Ph(2-Cl, 3-n-Pr, 5-c-Pr)</td><td>Ph(2-Cl, 3- i -Pr, 5-Br)</td>

<td>Ph(2-Cl, 3-Me, 5-OCF2CF2H)</td><td>Ph(2-Cl, 3-n-Pr, 5-CF3)</td><td>Ph(2-Cl, 3- i -Pr, 5-I)</td>

<td>Ph(2-Cl, 3-Me, 5-OC2F5)</td><td>Ph(2-Cl, 3-n-Pr, 5-C2F5)</td><td>Ph(2-Cl, 3- i -Pr, 5-Me)</td>

<td>Ph(2-Cl, 3-Me, 5-SO2Me)</td><td>Ph(2-Cl, 3-n-Pr, 5-CF2CF2H)</td><td>Ph(2-Cl, 3- i -Pr, 5-Et)</td>

<td>Ph(2-Cl, 3-Me, 5-TMS)</td><td>Ph(2-Cl, 3-n-Pr, 5-CF2H)</td><td>Ph(2-Cl, 3- i -Pr, 5-n-Pr)</td>

<td>Ph(2-Cl, 3-Me, 5-CN)</td><td>Ph(2-Cl, 3-n-Pr, 5-OMe)</td><td>Ph(2-Cl, 3- i -Pr, 5-1-Bu)</td>

<td>Ph(2-Cl, 3-Et, 5-Cl)</td><td>Ph(2-Cl, 3-n-Pr, 5-OCF3)</td><td>Ph(2-Cl, 3, 5-di-i-Pr)</td>

<td>Ph(2-Cl, 3-Et, 5-F)</td><td>Ph(2-Cl, 3-n-Pr, 5-OCHF2)</td><td>Ph(2-Cl, 3- i -Pr, 5- c -Pr)</td>

<td>Ph(2-Cl, 3-Et, 5-Br)</td><td>Ph(2-Cl, 3-n-Pr, 5-OCF2CF2H)</td><td>Ph(2-Cl, 3- i -Pr, 5-CF3)</td>

<td>Ph(2-Cl, 3-Et, 5-I)</td><td>Ph(2-Cl, 3-n-Pr, 5-OC2F5)</td><td>Ph(2-Cl, 3- i -Pr, 5-C2F5)</td>

<td>Ph(2-Cl, 3-Et, 5-Me)</td><td>Ph(2-Cl, 3-n-Pr, 5-SO2Me)</td><td>Ph(2-Cl, 3- i -Pr, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 3, 5-di-Et)</td><td>Ph(2-Cl, 3-n-Pr, 5-TMS)</td><td>Ph(2-Cl, 3- i -Pr, 5-CF2H)</td>

<td>Ph(2-Cl, 3-Et, 5-n-Pr)</td><td>Ph(2-Cl, 3-n-Pr, 5-CN)</td><td>Ph(2-Cl, 3- i -Pr, 5-OMe)</td>

<td>Ph(2-Cl, 3-Et, 5-1-Bu)</td><td>Ph(2-Cl, 3-1-Bu, 5-Cl)</td><td>Ph(2-Cl, 3- i -Pr, 5-OCF3)</td>

MD 4889 B1 2024.03.31

Q

Ph(2-Cl, 3- i -Pr, 5-OCHF2)

Ph(2-Cl, 3- i -Pr, 5-OCF2CF2H)

Ph(2-Cl, 3- i -Pr, 5-OC2F5)

Ph(2-Cl, 3- i -Pr, 5-SO2Me)

Ph(2-Cl, 3- i -Pr, 5-TMS)

Ph(2-Cl, 3- i -Pr, 5-CN)

Ph(2-Cl, 3- c -Pr, 5-Cl)

Ph(2-Cl, 3- c -Pr, 5-F)

Ph(2-Cl, 3- c -Pr, 5-Br)

Ph(2-Cl, 3- c -Pr, 5-I)

Ph(2-Cl, 3- c -Pr, 5-Me)

Ph(2-Cl, 3- c -Pr, 5-Et)

Ph(2-Cl, 3-c-Pr, 5-n-Pr)

Ph(2-Cl, 3- c -Pr, 5-1-Bu)

Ph(2-Cl, 3- c -Pr, 5- i -Pr) Ph(2-Cl, 3, 5-di- c -Pr)

Ph(2-Cl, 3- c -Pr, 5-CF3)

Ph(2-Cl, 3- c -Pr, 5-C2F5) Ph(2-Cl, 3- c -Pr, 5-CF2CF2H)

Ph(2-Cl, 3- c -Pr, 5-CF2H)

Ph(2-Cl, 3- c -Pr, 5-OMe)

Ph(2-Cl, 3- c -Pr, 5-OCF3) Ph(2-Cl, 3- c -Pr, 5-OCHF2)

Ph(2-Cl, 3- c -Pr, 5-OCF2CF2H)

Ph(2-Cl, 3- c -Pr, 5-OC2F5)

Ph(2-Cl, 3- c -Pr, 5-SO2Me)

Ph(2-Cl, 3- c -Pr, 5-TMS)

Ph(2-Cl, 3- c -Pr, 5-CN) Ph(2-Cl, 3-CF3, 5-Cl) Ph(2-Cl, 3-CF3, 5-F) Ph(2-Cl, 3-CF3, 5-Br)

Ph(2-Cl, 3-CF3, 5-I) Ph(2-Cl, 3-CF3, 5-Me)

Ph(2-Cl, 3-CF3, 5-Et) Ph(2-Cl, 3-CF3, 5-n-Pr)

Ph(2-Cl, 3-CF3, 5-1-Bu)

Ph(2-Cl, 3-CF3, 5- i -Pr)

Q

Ph(2-Cl, 3-CF3, 5- c -Pr) Ph(2-Cl, 3, 5-di-CF3) Ph(2-Cl, 3-CF3, 5-C2F5) Ph(2-Cl, 3-CF3, 5-CF2CF2H) Ph(2-Cl, 3-CF3, 5-CF2H) Ph(2-Cl, 3-CF3, 5-OMe) Ph(2-Cl, 3-CF3, 5-OCF3) Ph(2-Cl, 3-CF3, 5-OCHF2) Ph(2-Cl, 3-CF3, 5-OCF2CF2H) Ph(2-Cl, 3-CF3, 5-OC2F5) Ph(2-Cl, 3- CF3, 5-SO2Me) Ph(2-Cl, 3-CF3, 5-TMS) Ph(2-Cl, 3-CF3, 5-CN) Ph(2-Cl, 3-C2F5, 5-Cl) Ph(2-Cl, 3-C2F5, 5-F) Ph(2-Cl, 3-C2F5, 5-Br) Ph(2-Cl, 3-C2F5, 5-I) Ph(2-Cl, 3-C2F5, 5-Me) Ph(2-Cl, 3-C2F5, 5-Et) Ph(2-Cl, 3-C2F5, 5-n-Pr) Ph(2-Cl, 3-C2F5, 5-1-Bu) Ph(2-Cl, 3-C2F5, 5- i -Pr) Ph(2-Cl, 3-C2F5, 5- c -Pr) Ph(2-Cl, 3-C2F5CF3, 5-CF3) Ph(2-Cl, 3, 5-di-C2F5) Ph(2-Cl, 3-C2F5, 5-CF2CF2H) Ph(2-Cl, 3-C2F5, 5-CF2H) Ph(2-Cl, 3-C2F5, 5-OMe) Ph(2-Cl, 3-C2F5, 5-OCF3) Ph(2-Cl, 3-C2F5, 5-OCHF2) Ph(2-Cl, 3-C2F5, 5-OCF2CF2H) Ph(2-Cl, 3-C2F5, 5-OC2F5) Ph(2-Cl, 3- C2F5, 5-SO2Me) Ph(2-Cl, 3-C2F5, 5-TMS) Ph(2-Cl, 3-C2F5, 5-CN) Ph(2-Cl, 3-CF2CF2H, 5-Cl) Ph(2-Cl, 3-CF2CF2H, 5-F)

Q

Ph(2-Cl, 3-CF2CF2H, 5-Br) Ph(2-Cl, 3-CF2CF2H, 5-I) Ph(2-Cl, 3-CF2CF2H, 5-Me) Ph(2-Cl, 3- CF2CF2H, 5-Et) Ph(2-Cl, 3-CF2CF2H, 5-n-Pr) Ph(2-Cl, 3-CF2CF2H, 5-1-Bu) Ph(2-Cl, 3-CF2CF2H, 5- i -Pr) Ph(2-Cl, 3-CF2CF2H, 5- c -Pr) Ph(2-Cl, 3-CF2CF2H, 5-CF3) Ph(2-Cl, 3-CF2CF2H, 5-C2F5) Ph(2-Cl, 3, 5-di-CF2CF2H) Ph(2-Cl, 3-CF2CF2H, 5-CF2H) Ph(2-Cl, 3-CF2CF2H, 5-OMe) Ph(2-Cl, 3-CF2CF2H, 5-OCF3) Ph(2-Cl, 3-CF2CF2H, 5-OCHF2) Ph(2-Cl, 3-CF2CF2H, 5-OCF2CF2H) Ph(2-Cl, 3-CF2CF2H, 5-OC2F5) Ph(2- Cl, 3-CF2CF2H, 5-SO2Me) Ph(2-Cl, 3-CF2CF2H, 5-TMS) Ph(2-Cl, 3-CF2CF2H, 5-CN) Ph(2-Cl, 3-CF2H, 5-Cl) Ph(2-Cl, 3-CF2H, 5-F) Ph(2-Cl, 3- CF2H, 5-Br) Ph(2-Cl, 3-CF2H, 5-I) Ph(2-Cl, 3-CF2H, 5-Me) Ph(2-Cl, 3-CF2H, 5-Et) Ph(2-Cl, 3-CF2H, 5-n-Pr) Ph(2-Cl, 3-CF2H, 5-1-Bu) Ph(2-Cl, 3-CF2H, 5- i -Pr) Ph(2- Cl, 3-CF2H, 5- c -Pr) Ph(2-Cl, 3-CF2H, 5-CF3) Ph(2-Cl, 3-CF2H, 5-C2F5) Ph(2-Cl, 3-CF2H, 5-CF2CF2H) Ph(2-Cl, 3, 5-di-CF2H) Ph(2-Cl, 3-CF2H, 5-OMe) Ph(2-Cl, 3-CF2H, 5-OCF3) Ph(2- Cl, 3-CF2H, 5-OCHF2)

MD 4889 B1 2024.03.31

Q

Ph(2-Cl, 3-CF2H, 5-OCF2CF2H) Ph(2-Cl, 3-CF2H, 5-OC2F5) Ph(2-Cl, 3-CF2H, 5-SO2Me) Ph(2-Cl, 3- CF2H, 5-TMS) Ph(2-Cl, 3-CF2H, 5-CN) Ph(2-Cl, 3-OMe, 5-Cl) Ph(2-Cl, 3-OMe, 5-F) Ph(2-Cl, 3-OMe, 5-Br) Ph(2-Cl, 3-OMe, 5-I) Ph(2-Cl, 3-OMe, 5-Me) Ph(2-Cl, 3-OMe, 5-Et) Ph(2-Cl, 3-OMe, 5-n-Pr) Ph(2-Cl, 3-OMe, 5-1-Bu) Ph(2-Cl, 3-OMe, 5- i - Pr) Ph(2-Cl, 3-OMe, 5- c -Pr) Ph(2-Cl, 3-OMe, 5-CF3) Ph(2-Cl, 3-OMe, 5-C2F5) Ph(2- Cl, 3-OMe, 5-CF2CF2H) Ph(2-Cl, 3-OMe, 5-CF2H) Ph(2-Cl, 3, 5-di-OMe) Ph(2-Cl, 3-OMe, 5- OCF3) Ph(2-Cl, 3-OMe, 5-OCHF2) Ph(2-Cl, 3-OMe, 5-OCF2CF2H) Ph(2-Cl, 3-OMe, 5-OC2F5) Ph(2-Cl, 3-OMe, 5-SO2Me) Ph(2-Cl, 3- OMe, 5-TMS) Ph(2-Cl, 3-OMe, 5-CN) Ph(2-Cl, 3-OCF3, 5-Cl) Ph(2-Cl, 3-OCF3, 5-F) Ph(2-Cl, 3-OCF3, 5-Br) Ph(2-Cl, 3-OCF3, 5-I) Ph(2-Cl, 3-OCF3, 5-Me) Ph(2-Cl, 3-OCF3, 5-Et) Ph(2-Cl, 3-OCF3, 5-n-Pr) Ph(2-Cl, 3-OCF3, 5-1-Bu) Ph(2-Cl, 3-OCF3, 5- i - Pr) Ph(2-Cl, 3-OCF3, 5- c -Pr)

Q

Ph(2-Cl, 3-OCF3, 5-CF3) Ph(2-Cl, 3-OCF3, 5-C2F5) Ph(2-Cl, 3-OCF3, 5-CF2CF2H) Ph(2-Cl, 3- OCF3, 5-CF2H) Ph(2-Cl, 3-OCF3, 5-OMe) Ph(2-Cl, 3, 5-di-OCF3) Ph(2-Cl, 3-OCF3, 5-OCHF2) Ph(2-Cl, 3-OCF3, 5-OCF2CF2H) Ph(2-Cl, 3-OCF3, 5-OC2F5) Ph(2-Cl, 3-OCF3, 5-SO2Me) Ph(2-Cl, 3-OCF3, 5-TMS) Ph(2-Cl, 3-OCF3, 5-CN) Ph(2-Cl, 3-OCHF2, 5-Cl) Ph(2-Cl, 3-OCHF2, 5-F) Ph(2- Cl, 3-OCHF2, 5-Br) Ph(2-Cl, 3-OCHF2, 5-I) Ph(2-Cl, 3-OCHF2, 5-Me) Ph(2-Cl, 3-OCHF2, 5- Et) Ph(2-Cl, 3-OCHF2, 5-n-Pr) Ph(2-Cl, 3-OCHF2, 5-t-Bu) Ph(2-Cl, 3-OCHF2, 5-i -Pr) Ph(2-Cl, 3-OCHF2, 5-c -Pr) Ph(2-Cl, 3-OCHF2CF3, 5-CF3) Ph(2-Cl, 3-OC2F5, 5-C2F5) Ph(2-Cl, 3-OCHF2, 5-CF2CF2H) Ph(2-Cl, 3-OCHF2, 5-CF2H) Ph(2-Cl, 3-OCHF2, 5-OMe) Ph(2-Cl, 3-OCHF2, 5-OCF3) Ph(2-Cl, 3, 5-di-OCHF2) Ph(2-Cl, 3-OCHF2, 5-OCF2CF2H) Ph(2-Cl, 3-OCHF2, 5-OC2F5) Ph(2-Cl, 3- OCHF2, 5-SO2Me) Ph(2-Cl, 3-OCHF2, 5-TMS) Ph(2-Cl, 3-OCHF2, 5-CN) Ph(2-Cl, 3-OCF2CF2H, 5-Cl) Ph(2-Cl, 3-OCF2CF2H, 5-F) Ph(2-Cl, 3-OCF2CF2H, 5-Br)

Q

Ph(2-Cl, 3-OCF2CF2H, 5-I) Ph(2-Cl, 3-OCF2CF2H, 5-Me) Ph(2-Cl, 3-OCF2CF2H, 5-Et) Ph(2-Cl, 3- OCF2CF2H, 5-n-Pr) Ph(2-Cl, 3-OCF2CF2H, 5-t-Bu) Ph(2-Cl, 3-OCF2CF2H, 5-i -Pr) Ph(2-Cl, 3-OCF2CF2H, 5-c -Pr) Ph(2-Cl, 3-OCF2CF2H, 5-CF3) Ph(2-Cl, 3-OCF2CF2H, 5-C2F5) Ph(2-Cl, 3-OCF2CF2H, 5-CF2CF2H) Ph(2-Cl, 3-OCF2CF2H, 5-CF2H) Ph(2-Cl, 3-OCF2CF2H, 5-OMe) Ph(2-Cl, 3-OCF2CF2H, 5-OCF3) Ph(2-Cl, 3-OCF2CF2H, 5-OCHF2) Ph(2-Cl, 3, 5-di-OCF2CF2H) Ph(2-Cl, 3-OCF2CF2H, 5-OC2F5) Ph(2-Cl, 3-OCF2CF2H, 5-SO2Me) Ph(2- Cl, 3-OCF2CF2H, 5-TMS) Ph(2-Cl, 3-OCF2CF2H, 5-CN) Ph(2-Cl, 3-OC2F5, 5-Cl) Ph(2-Cl, 3-OC2F5, 5-F)

Ph(2-Cl, 3-OC2F5, 5-Br) Ph(2-Cl, 3-OC2F5, 5-I) Ph(2-Cl, 3-OC2F5, 5-Me) Ph(2-Cl, 3- OC2F5, 5-Et) Ph(2-Cl, 3-OC2F5, 5-n-Pr) Ph(2-Cl, 3-OC2F5, 5-1-Bu) Ph(2-Cl, 3-OC2F5, 5- i -Pr) Ph(2-Cl, 3-OC2F5, 5- c -Pr) Ph(2-Cl, 3-OC2F5CF3, 5-CF3) Ph(2-Cl, 3-OC2F5, 5-CF2CF2H) Ph(2-Cl, 3-OC2F5, 5-CF2H) Ph(2-Cl, 3-OC2F5, 5-OMe) Ph(2-Cl, 3-OC2F5, 5-OCF3) Ph(2-Cl, 3-OC2F5, 5-OCHF2) Ph(2-Cl, 3-OC2F5, 5-OCF2CF2H) Ph(2-Cl, 3, 5-di-OC2F5)

MD 4889 B1 2024.03.31

<td>Q¹</td><td>56 Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 3-OC2F5, 5-SO2Me)</td><td>Ph(2-Cl, 3-TMS, 5-CF2CF2H)</td><td>Ph(2-Cl, 4-Cl, 5-Et)</td>

<td>Ph(2-Cl, 3-OC2F5, 5-TMS)</td><td>Ph(2-Cl, 3-TMS, 5-CF2H)</td><td>Ph(2-Cl, 4-Cl, 5-n-Pr)</td>

<td>Ph(2-Cl, 3-OC2F5, 5-CN)</td><td>Ph(2-Cl, 3-TMS, 5-OMe)</td><td>Ph(2-Cl, 4-Cl, 5-1-Bu)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-Cl)</td><td>Ph(2-Cl, 3-TMS, 5-OCF3)</td><td>Ph(2-Cl, 4-Cl, 5- i -Pr)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-F)</td><td>Ph(2-Cl, 3-TMS, 5-OCHF2)</td><td>Ph(2-Cl, 4-Cl, 5- c -Pr)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-Br)</td><td>Ph(2-Cl, 3-TMS, 5-OCF2CF2H)</td><td>Ph(2-Cl, 4-Cl, 5-CF3)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-I)</td><td>Ph(2-Cl, 3-TMS, 5-OC2F5)</td><td>Ph(2-Cl, 4-Cl, 5-C2F5)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-Me)</td><td>Ph(2-Cl, 3-TMS, 5-SO2Me)</td><td>Ph(2-Cl, 4-Cl, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-Et)</td><td>Ph(2-Cl, 3, 5-di-TMS)</td><td>Ph(2-Cl, 4-Cl, 5-CF2H)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-n-Pr)</td><td>Ph(2-Cl, 3-TMS, 5-CN)</td><td>Ph(2-Cl, 4-Cl, 5-OMe)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-1-Bu)</td><td>Ph(2-Cl, 3-CN, 5-Cl)</td><td>Ph(2-Cl, 4-Cl, 5-OCF3)</td>

<td>Ph(2-Cl, 3-SO2Me, 5- i -Pr)</td><td>Ph(2-Cl, 3-CN, 5-F)</td><td>Ph(2-Cl, 4-Cl, 5-OCHF2)</td>

<td>Ph(2-Cl, 3-SO2Me, 5- c -Pr)</td><td>Ph(2-Cl, 3-CN, 5-Br)</td><td>Ph(2-Cl, 4-Cl, 5-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-SO2MeCF3, 5-CF3)</td><td>Ph(2-Cl, 3-CN, 5-I)</td><td>Ph(2-Cl, 4-Cl, 5-OC2F5)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-C2F5)</td><td>Ph(2-Cl, 3-CN, 5-Me)</td><td>Ph(2-Cl, 4-Cl, 5-SO2Me)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-CF2CF2H)</td><td>Ph(2-Cl, 3-CN, 5-Et)</td><td>Ph(2-Cl, 4-Cl, 5-TMS)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-CF2H)</td><td>Ph(2-Cl, 3-CN, 5-n-Pr)</td><td>Ph(2-Cl, 4-Cl, 5-CN)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-OMe)</td><td>Ph(2-Cl, 3-CN, 5-1-Bu)</td><td>Ph(2-Cl, 4-F, 5-Cl)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-OCF3)</td><td>Ph(2-Cl, 3-CN, 5- i -Pr)</td><td>Ph(2-Cl, 4, 5-di-F)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-OCHF2)</td><td>Ph(2-Cl, 3-CN, 5- c -Pr)</td><td>Ph(2-Cl, 4-F, 5-Br)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-OCF2CF2H)</td><td>Ph(2-Cl, 3-CN, 5-CF3)</td><td>Ph(2-Cl, 4-F, 5-I)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-OC2F5)</td><td>Ph(2-Cl, 3-CN, 5-C2F5)</td><td>Ph(2-Cl, 4-F, 5-Me)</td>

<td>Ph(2-Cl, 3, 5-di-SO2Me)</td><td>Ph(2-Cl, 3-CN, 5-CF2CF2H)</td><td>Ph(2-Cl, 4-F, 5-Et)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-TMS)</td><td>Ph(2-Cl, 3-CN, 5-CF2H)</td><td>Ph(2-Cl, 4-F, 5-n-Pr)</td>

<td>Ph(2-Cl, 3-SO2Me, 5-CN)</td><td>Ph(2-Cl, 3-CN, 5-OMe)</td><td>Ph(2-Cl, 4-F, 5-1-Bu)</td>

<td>Ph(2-Cl, 3-TMS, 5-Cl)</td><td>Ph(2-Cl, 3-CN, 5-OCF3)</td><td>Ph(2-Cl, 4-F, 5- i -Pr)</td>

<td>Ph(2-Cl, 3-TMS, 5-F)</td><td>Ph(2-Cl, 3-CN, 5-OCHF2)</td><td>Ph(2-Cl, 4-F, 5- c -Pr)</td>

<td>Ph(2-Cl, 3-TMS, 5-Br)</td><td>Ph(2-Cl, 3-CN, 5-OCF2CF2H)</td><td>Ph(2-Cl, 4-F, 5-CF3)</td>

<td>Ph(2-Cl, 3-TMS, 5-I)</td><td>Ph(2-Cl, 3-CN, 5-OC2F5)</td><td>Ph(2-Cl, 4-F, 5-C2F5)</td>

<td>Ph(2-Cl, 3-TMS, 5-Me)</td><td>Ph(2-Cl, 3-CN, 5-SO2Me)</td><td>Ph(2-Cl, 4-F, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 3-TMS, 5-Et)</td><td>Ph(2-Cl, 3-CN, 5-TMS)</td><td>Ph(2-Cl, 4-F, 5-CF2H)</td>

<td>Ph(2-Cl, 3-TMS, 5-n-Pr)</td><td>Ph(2-Cl, 3, 5-di-CN)</td><td>Ph(2-Cl, 4-F, 5-OMe)</td>

<td>Ph(2-Cl, 3-TMS, 5-1-Bu)</td><td>Ph(2, 4, 5-tri-Cl)</td><td>Ph(2-Cl, 4-F, 5-OCF3)</td>

<td>Ph(2-Cl, 3-TMS, 5- i -Pr)</td><td>Ph(2-Cl, 4-Cl, 5-F)</td><td>Ph(2-Cl, 4-F, 5-OCHF2)</td>

<td>Ph(2-Cl, 3-TMS, 5- c -Pr)</td><td>Ph(2-Cl, 4-Cl, 5-Br)</td><td>Ph(2-Cl, 4-F, 5-OCF2CF2H)</td>

<td>Ph(2-Cl, 3-TMS, 5-CF3)</td><td>Ph(2-Cl, 4-Cl, 5-I)</td><td>Ph(2-Cl, 4-F, 5-OC2F5)</td>

<td>Ph(2-Cl, 3-TMS, 5-C2F5)</td><td>Ph(2-Cl, 4-Cl, 5-Me)</td><td>Ph(2-Cl, 4-F, 5-SO2Me)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-Cl, 4-F, 5-TMS)</td><td>Ph(2-Cl, 4-I, 5-CF2H)</td><td>Ph(2-Cl, 4-Et, 5-n-Pr)</td>

<td>Ph(2-Cl, 4-F, 5-CN)</td><td>Ph(2-Cl, 4-I, 5-OMe)</td><td>Ph(2-Cl, 4-Et, 5-1-Bu)</td>

<td>Ph(2-Cl, 4-Br, 5-Cl)</td><td>Ph(2-Cl, 4-I, 5-OCF3)</td><td>Ph(2-Cl, 4-Et, 5- i -Pr)</td>

<td>Ph(2-Cl, 4-Br, 5-F)</td><td>Ph(2-Cl, 4-I, 5-OCHF2)</td><td>Ph(2-Cl, 4-Et, 5- c -Pr)</td>

<td>Ph(2-Cl, 4, 5-di-Br)</td><td>Ph(2-Cl, 4-I, 5-OCF2CF2H)</td><td>Ph(2-Cl, 4-Et, 5-CF3)</td>

<td>Ph(2-Cl, 4-Br, 5-I)</td><td>Ph(2-Cl, 4-I, 5-OC2F5)</td><td>Ph(2-Cl, 4-Et, 5-C2F5)</td>

<td>Ph(2-Cl, 4-Br, 5-Me)</td><td>Ph(2-Cl, 4-I, 5-SO2Me)</td><td>Ph(2-Cl, 4-Et, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 4-Br, 5-Et)</td><td>Ph(2-Cl, 4-I, 5-TMS)</td><td>Ph(2-Cl, 4-Et, 5-CF2H)</td>

<td>Ph(2-Cl, 4-Br, 5-n-Pr)</td><td>Ph(2-Cl, 4-I, 5-CN)</td><td>Ph(2-Cl, 4-Et, 5-OMe)</td>

<td>Ph(2-Cl, 4-Br, 5-1-Bu)</td><td>Ph(2-Cl, 4-Me, 5-Cl)</td><td>Ph(2-Cl, 4-Et, 5-OCF3)</td>

<td>Ph(2-Cl, 4-Br, 5- i -Pr)</td><td>Ph(2-Cl, 4-Me, 5-F)</td><td>Ph(2-Cl, 4-Et, 5-OCHF2)</td>

<td>Ph(2-Cl, 4-Br, 5- c -Pr)</td><td>Ph(2-Cl, 4-Me, 5-Br)</td><td>Ph(2-Cl, 4-Et, 5-OCF2CF2H)</td>

<td>Ph(2-Cl, 4-Br, 5-CF3)</td><td>Ph(2-Cl, 4-Me, 5-I)</td><td>Ph(2-Cl, 4-Et, 5-OC2F5)</td>

<td>Ph(2-Cl, 4-Br, 5-C2F5)</td><td>Ph(2-Cl, 4, 5-di-Me)</td><td>Ph(2-Cl, 4-Et, 5-SO2Me)</td>

<td>Ph(2-Cl, 4-Br, 5-CF2CF2H)</td><td>Ph(2-Cl, 4-Me, 5-Et)</td><td>Ph(2-Cl, 4-Et, 5-TMS)</td>

<td>Ph(2-Cl, 4-Br, 5-CF2H)</td><td>Ph(2-Cl, 4-Me, 5-n-Pr)</td><td>Ph(2-Cl, 4-Et, 5-CN)</td>

<td>Ph(2-Cl, 4-Br, 5-OMe)</td><td>Ph(2-Cl, 4-Me, 5-1-Bu)</td><td>Ph(2-Cl, 4-n-Pr, 5-Cl)</td>

<td>Ph(2-Cl, 4-Br, 5-OCF3)</td><td>Ph(2-Cl, 4-Me, 5- i -Pr)</td><td>Ph(2-Cl, 4-n-Pr, 5-F)</td>

<td>Ph(2-Cl, 4-Br, 5-OCHF2)</td><td>Ph(2-Cl, 4-Me, 5- c -Pr)</td><td>Ph(2-Cl, 4-n-Pr, 5-Br)</td>

<td>Ph(2-Cl, 4-Br, 5-OCF2CF2H)</td><td>Ph(2-Cl, 4-Me, 5-CF3)</td><td>Ph(2-Cl, 4-n-Pr, 5-I)</td>

<td>Ph(2-Cl, 4-Br, 5-OC2F5)</td><td>Ph(2-Cl, 4-Me, 5-C2F5)</td><td>Ph(2-Cl, 4-n-Pr, 5-Me)</td>

<td>Ph(2-Cl, 4-Br, 5-SO2Me)</td><td>Ph(2-Cl, 4-Me, 5-CF2CF2H)</td><td>Ph(2-Cl, 4-n-Pr, 5-Et)</td>

<td>Ph(2-Cl, 4-Br, 5-TMS)</td><td>Ph(2-Cl, 4-Me, 5-CF2H)</td><td>Ph(2-Cl, 4, 5-di-n-Pr)</td>

<td>Ph(2-Cl, 4-Br, 5-CN)</td><td>Ph(2-Cl, 4-Me, 5-OMe)</td><td>Ph(2-Cl, 4-n-Pr, 5-t-Bu)</td>

<td>Ph(2-Cl, 4-I, 5-Cl)</td><td>Ph(2-Cl, 4-Me, 5-OCF3)</td><td>Ph(2-Cl, 4-n-Pr, 5-i-Pr)</td>

<td>Ph(2-Cl, 4-I, 5-F)</td><td>Ph(2-Cl, 4-Me, 5-OCHF2)</td><td>Ph(2-Cl, 4-n-Pr, 5-c-Pr)</td>

<td>Ph(2-Cl, 4-I, 5-Br)</td><td>Ph(2-Cl, 4-Me, 5-OCF2CF2H)</td><td>Ph(2-Cl, 4-n-Pr, 5-CF3)</td>

<td>Ph(2-Cl, 4, 5-di-I)</td><td>Ph(2-Cl, 4-Me, 5-OC2F5)</td><td>Ph(2-Cl, 4-n-Pr, 5-C2F5)</td>

<td>Ph(2-Cl, 4-I, 5-Me)</td><td>Ph(2-Cl, 4-Me, 5-SO2Me)</td><td>Ph(2-Cl, 4-n-Pr, 5-CF2CF2H)</td>

<td>Ph(2-Cl, 4-I, 5-Et)</td><td>Ph(2-Cl, 4-Me, 5-TMS)</td><td>Ph(2-Cl, 4-n-Pr, 5-CF2H)</td>

<td>Ph(2-Cl, 4-I, 5-n-Pr)</td><td>Ph(2-Cl, 4-Me, 5-CN)</td><td>Ph(2-Cl, 4-n-Pr, 5-OMe)</td>

<td>Ph(2-Cl, 4-I, 5-1-Bu)</td><td>Ph(2-Cl, 4-Et, 5-Cl)</td><td>Ph(2-Cl, 4-n-Pr, 5-OCF3)</td>

<td>Ph(2-Cl, 4-I, 5- i -Pr)</td><td>Ph(2-Cl, 4-Et, 5-F)</td><td>Ph(2-Cl, 4-n-Pr, 5-OCHF2)</td>

<td>Ph(2-Cl, 4-I, 5- c -Pr)</td><td>Ph(2-Cl, 4-Et, 5-Br)</td><td>Ph(2-Cl, 4-n-Pr, 5-OCF2CF2H)</td>

<td>Ph(2-Cl, 4-I, 5-CF3)</td><td>Ph(2-Cl, 4-Et, 5-I)</td><td>Ph(2-Cl, 4-n-Pr, 5-OC2F5)</td>

<td>Ph(2-Cl, 4-I, 5-C2F5)</td><td>Ph(2-Cl, 4-Et, 5-Me)</td><td>Ph(2-Cl, 4-n-Pr, 5-SO2Me)</td>

<td>Ph(2-Cl, 4-I, 5-CF2CF2H)</td><td>Ph(2-Cl, 4, 5-di-Et)</td><td>Ph(2-Cl, 4-n-Pr, 5-TMS)</td>

MD 4889 B1 2024.03.31

Q

Ph(2-Cl, 4-n-Pr, 5-CN)

Ph(2-Cl, 4-1-Bu, 5-Cl)

Ph(2-Cl, 4-1-Bu, 5-F)

Ph(2-Cl, 4-1-Bu, 5-Br)

Ph(2-Cl, 4-1-Bu, 5-I)

Ph(2-Cl, 4-1-Bu, 5-Me)

Ph(2-Cl, 4-1-Bu, 5-Et)

Ph(2-Cl, 4-1-Bu, 5-n-Pr)

Ph(2-Cl, 4, 5-di-1-Bu)

Ph(2-Cl, 4-1-Bu, 5- i -Pr)

Ph(2-Cl, 4-1-Bu, 5- c -Pr)

Ph(2-Cl, 4-1-Bu, 5-CF3)

Ph(2-Cl, 4-1-Bii, 5-CF.)

Ph(2-Cl, 4-1-Bu, 5-CF2CF2H)

Ph(2-Cl, 4-1-Bu, 5-CF2H)

Ph(2-Cl, 4-1-Bu, 5-OMe)

Ph(2-Cl, 4-1-Bu, 5-OCF3)

Ph(2-Cl, 4-1-Bu, 5-OCHF2)

Ph(2-Cl, 4-1-Bu, 5-OCF2CF2H)

Ph(2-Cl, 4-1-Bii, 5-O)CT.)

Ph(2-Cl, 4-1-Bu, 5-SO2Me)

Ph(2-Cl, 4-1-Bu, 5-TMS)

Ph(2-Cl, 4-1-Bu, 5-CN)

Ph(2-Cl, 4- i -Pr, 5-Cl)

Ph(2-Cl, 4- i -Pr, 5-F)

Ph(2-Cl, 4- i -Pr, 5-Br)

Ph(2-Cl, 4- i -Pr, 5-I)

Ph(2-Cl, 4- i -Pr, 5-Me)

Ph(2-Cl, 4- i -Pr, 5-Et)

Ph(2-Cl, 4- i -Pr, 5-n-Pr)

Ph(2-Cl, 4- i -Pr, 5-1-Bu)

Ph(2-Cl, 4, 5-di-i-Pr)

Ph(2-Cl, 4- i -Pr, 5- c -Pr)

Ph(2-Cl, 4- i -Pr, 5-CF3)

Ph(2-Cl, 4- i -Pr, 5-C2F5)

Ph(2-Cl, 4- i -Pr, 5-CF2CF2H)

Ph(2-Cl, 4- i -Pr, 5-CF2H)

Q

Ph(2-Cl, 4- i -Pr, 5-OMe) Ph(2-Cl, 4- i -Pr, 5-OCF3) Ph(2-Cl, 4- i -Pr, 5-OCHF2) Ph(2-Cl, 4- i -Pr, 5-OCF2CF2H) Ph(2-Cl, 4- i -Pr, 5-OC2F5) Ph(2-Cl, 4- i -Pr, 5-SO2Me) Ph(2- Cl, 4- i -Pr, 5-TMS) Ph(2-Cl, 4- i -Pr, 5-CN) Ph(2-Cl, 4- c -Pr, 5-Cl)

Ph(2-Cl, 4- c -Pr, 5-F) Ph(2-Cl, 4- c -Pr, 5-Br) Ph(2-Cl, 4- c -Pr, 5-I) Ph(2-Cl, 4- c -Pr, 5-Me) Ph(2-Cl, 4- c -Pr, 5-Et) Ph(2-Cl, 4- c -Pr, 5-n-Pr) Ph(2-Cl, 4- c -Pr, 5-1-Bu) Ph(2-Cl, 4- c -Pr, 5- i -Pr) Ph(2-Cl, 4, 5-di- c -Pr) Ph(2-Cl, 4- c -Pr, 5-CF3) Ph(2-Cl, 4- c -Pr, 5-C2F5) Ph(2-Cl, 4- c -Pr, 5-CF2CF2H) Ph(2-Cl, 4- c -Pr, 5-CF2H) Ph(2-Cl, 4- c -Pr, 5-OMe) Ph(2-Cl, 4- c -Pr, 5-OCF3) Ph(2- Cl, 4- c -Pr, 5-OCHF2) Ph(2-Cl, 4- c -Pr, 5-OCF2CF2H) Ph(2-Cl, 4- c -Pr, 5-OC2F5) Ph(2-Cl, 4- c -Pr, 5-SO2Me) Ph(2-Cl, 4- c -Pr, 5-TMS) Ph(2-Cl, 4- c -Pr, 5-CN) Ph(2-Cl, 4-CF3, 5-Cl) Ph(2-Cl, 4-CF3, 5-F) Ph(2-Cl, 4-CF3, 5-Br)

Ph(2-Cl, 4-CF3, 5-I) Ph(2-Cl, 4-CF3, 5-Me) Ph(2-Cl, 4-CF3, 5-Et) Ph(2-Cl, 4- CF3, 5-n-Pr)

Q

Ph(2-Cl, 4-CF3, 5-1-Bu) Ph(2-Cl, 4-CF3, 5- i -Pr) Ph(2-Cl, 4-CF3, 5- c -Pr) Ph(2-Cl, 4, 5-di-CF3) Ph(2-Cl, 4-CF3, 5-C2F5) Ph(2-Cl, 4-CF3, 5-CF2CF2H) Ph(2-Cl, 4-CF3, 5-CF2H) Ph(2-Cl, 4-CF3, 5-OMe) Ph(2-Cl, 4-CF3, 5-OCF3) Ph(2-Cl, 4-CF3, 5-OCHF2) Ph(2- Cl, 4-CF3, 5-OCF2CF2H) Ph(2-Cl, 4-CF3, 5-OC2F5) Ph(2-Cl, 4-CF3, 5-SO2Me) Ph(2-Cl, 4-CF3, 5- TMS) Ph(2-Cl, 4-CF3, 5-CN) Ph(2-Cl, 4-CF2CF3, 5-Cl) Ph(2-Cl, 4-CF2CF3, 5-F) Ph(2-Cl, 4-CF2CF3, 5-Br) Ph(2-Cl, 4-CF2CF3, 5-I) Ph(2-Cl, 4-CF2CF3, 5-Me) Ph(2-Cl, 4-CF2CF3, 5-Et) Ph(2-Cl, 4-CF2CF3, 5-n-Pr) Ph(2-Cl, 4-CF2CF3, 5-1-Bu) Ph(2-Cl, 4-CF2CF3, 5- i -Pr) Ph(2-Cl, 4-CF2CF3, 5- c -Pr) Ph(2-Cl, 4-C2F5CF3, 5-CF3) Ph(2-Cl, 4, 5-di-C2F5) Ph(2-Cl, 4-CF2CF3, 5-CF2CF2H) Ph(2-Cl, 4-CF2CF3, 5-CF2H) Ph(2-Cl, 4-CF2CF3, 5-OMe) Ph(2-Cl, 4-CF2CF3, 5-OCF3) Ph(2-Cl, 4-CF2CF3, 5-OCHF2) Ph(2- Cl, 4-CF2CF3, 5-OCF2CF2H) Ph(2-Cl, 4-CF2CF3, 5-OC2F5) Ph(2-Cl, 4-CF2CF3, 5-SO2Me) Ph(2-Cl, 4-CF2CF3, 5- TMS) Ph(2-Cl, 4-CF2CF3, 5-CN)

MD 4889 B1 2024.03.31

Q

Ph(2-Cl, 4-CF2CF2H, 5-Cl) Ph(2-Cl, 4-CF2CF2H, 5-F) Ph(2-Cl, 4-CF2CF2H, 5-Br) Ph(2-Cl, 4- CF2CF2H, 5-I) Ph(2-Cl, 4-CF2CF2H, 5-Me) Ph(2-Cl, 4-CF2CF2H, 5-Et) Ph(2-Cl, 4-CF2CF2H, 5-n-Pr) Ph(2-Cl, 4-CF2CF2H, 5-1-Bu) Ph(2-Cl, 4-CF2CF2H, 5- i -Pr) Ph(2-Cl, 4-CF2CF2H, 5- c -Pr) Ph(2-Cl, 4-CF2CF2CF3H, 5-CF3) Ph(2-Cl, 4-CF2CF2H, 5-C2F5) Ph(2-Cl, 4, 5-di-CF2CF2H)

Ph(2-Cl, 4-CF2CF2H, 5-CF2H) Ph(2-Cl, 4-CF2CF2H, 5-OMe) Ph(2-Cl, 4-CF2CF2H, 5-OCF3) Ph(2-Cl, 4- CF2CF2H, 5-OCHF2) Ph(2-Cl, 4-CF2CF2H, 5-OCF2CF2H) Ph(2-Cl, 4-CF2CF2H, 5-OC2F5) Ph(2-Cl, 4-CF2CF2H, 5-SO2Me) Ph(2-Cl, 4-CF2CF2H, 5-TMS) Ph(2-Cl, 4-CF2CF2H, 5-CN)

Ph(2-Cl, 4-CF2H, 5-Cl) Ph(2-Cl, 4-CF2H, 5-F) Ph(2-Cl, 4-CF2H, 5-Br) Ph(2-Cl, 4- CF2H, 5-I) Ph(2-Cl, 4-CF2H, 5-Me) Ph(2-Cl, 4-CF2H, 5-Et) Ph(2-Cl, 4-CF2H, 5-n-Pr) Ph(2-Cl, 4-CF2H, 5-1-Bu) Ph(2-Cl, 4-CF2H, 5- i -Pr) Ph(2-Cl, 4-CF2H, 5- c -Pr) Ph(2-Cl, 4-CF2H, 5-CF3) Ph(2-Cl, 4-CF2H, 5-C2F5) Ph(2-Cl, 4-CF2H, 5-CF2CF2H)

Ph(2-Cl, 4, 5-di-CF2H) Ph(2-Cl, 4-CF2H, 5-OMe)

Q

Ph(2-Cl, 4-CF2H, 5-OCF3) Ph(2-Cl, 4-CF2H, 5-OCHF2) Ph(2-Cl, 4-CF2H, 5-OCF2CF2H) Ph(2-Cl, 4- CF2H, 5-OC2F5) Ph(2-Cl, 4-CF2H, 5-SO2Me) Ph(2-Cl, 4-CF2H, 5-TMS) Ph(2-Cl, 4-CF2H, 5-CN) Ph(2-Cl, 4-OMe, 5-Cl) Ph(2-Cl, 4-OMe, 5-F) Ph(2-Cl, 4-OMe, 5-Br) Ph(2-Cl, 4-OMe, 5-I) Ph(2-Cl, 4-OMe, 5-Me) Ph(2-Cl, 4-OMe, 5-Et) Ph(2-Cl, 4-OMe, 5-n-Pr) Ph(2-Cl, 4-OMe, 5-1-Bu) Ph(2-Cl, 4-OMe, 5- i -Pr) Ph(2-Cl, 4-OMe, 5- c -Pr) Ph(2- Cl, 4-OMeCF3, 5-CF3) Ph(2-Cl, 4-OMe, 5-C2F5) Ph(2-Cl, 4-OMe, 5-CF2CF2H) Ph(2-Cl, 4-OMe, 5- CF2H) Ph(2-Cl, 4, 5-di-OMe) Ph(2-Cl, 4-OMe, 5-OCF3) Ph(2-Cl, 4-OMe, 5-OCHF2) Ph(2-Cl, 4-OMe, 5-OCF2CF2H) Ph(2-Cl, 4- OMe, 5-OC2F5) Ph(2-Cl, 4-OMe, 5-SO2Me) Ph(2-Cl, 4-OMe, 5-TMS) Ph(2-Cl, 4-OMe, 5-CN) Ph(2-Cl, 4-OCF3, 5-Cl) Ph(2-Cl, 4-OCF3, 5-F) Ph(2-Cl, 4-OCF3, 5-Br) Ph(2-Cl, 4-OCF3, 5-I) Ph(2-Cl, 4-OCF3, 5-Me) Ph(2-Cl, 4-OCF3, 5-Et) Ph(2-Cl, 4-OCF3, 5-n-Pr) Ph(2-Cl, 4-OCF3, 5-1-Bu)

Q

Ph(2-Cl, 4-OCF3, 5- i -Pr) Ph(2-Cl, 4-OCF3, 5- c -Pr) Ph(2-Cl, 4-OCF3, 5-CF3) Ph(2- Cl, 4-OCF3, 5-C2F5) Ph(2-Cl, 4-OCF3, 5-CF2CF2H) Ph(2-Cl, 4-OCF3, 5-CF2H) Ph(2-Cl, 4-OCF3, 5- OMe) Ph(2-Cl, 4, 5-di-OCF3) Ph(2-Cl, 4-OCF3, 5-OCHF2) Ph(2-Cl, 4-OCF3, 5-OCF2CF2H) Ph(2-Cl, 4-OCF3, 5-OC2F5) Ph(2-Cl, 4-OCF3, 5-SO2Me) Ph(2-Cl, 4-OCF3, 5-TMS) Ph(2-Cl, 4-OCF3, 5-CN) Ph(2-Cl, 4-OCHF2, 5-Cl) Ph(2-Cl, 4-OCHF2, 5-F) Ph(2-Cl, 4-OCHF2, 5-Br) Ph(2-Cl, 4- OCHF2, 5-I) Ph(2-Cl, 4-OCHF2, 5-Me) Ph(2-Cl, 4-OCHF2, 5-Et) Ph(2-Cl, 4-OCHF2, 5-n-Pr) Ph(2-Cl, 4-OCHF2, 5-t-Bu) Ph(2-Cl, 4-OCHF2, 5-i -Pr) Ph(2-Cl, 4-OCHF2, 5-c -Pr) Ph(2-Cl, 4-OCHF2CF3, 5-CF3) Ph(2-Cl, 4-OCF2CF3, 5-C2F5) Ph(2-Cl, 4-OCHF2, 5-CF2CF2H) Ph(2-Cl, 4-OCHF2, 5-CF2H) Ph(2-Cl, 4-OCHF2, 5-OMe) Ph(2-Cl, 4-OCHF2, 5-OCF3) Ph(2-Cl, 4, 5-di-OCHF2) Ph(2- Cl, 4-OCHF2, 5-OCF2CF2H) Ph(2-Cl, 4-OCHF2, 5-OC2F5) Ph(2-Cl, 4-OCHF2, 5-SO2Me) Ph(2-Cl, 4-OCHF2, 5- TMS) Ph(2-Cl, 4-OCHF2, 5-CN) Ph(2-Cl, 4-OCF2CF2H, 5-Cl)

MD 4889 B1 2024.03.31

Q

Ph(2-Cl, 4-OCF2CF2H, 5-F) Ph(2-Cl, 4-OCF2CF2H, 5-Br) Ph(2-Cl, 4-OCF2CF2H, 5-I) Ph(2-Cl, 4- OCF2CF2H, 5-Me) Ph(2-Cl, 4-OCF2CF2H, 5-Et) Ph(2-Cl, 4-OCF2CF2H, 5-n-Pr) Ph(2-Cl, 4-OCF2CF2H, 5-1- Bu) Ph(2-Cl, 4-OCF2CF2H, 5-i -Pr) Ph(2-Cl, 4-OCF2CF2H, 5-c -Pr) Ph(2-Cl, 4-OCF2CF2CF3H, 5-CF3) Ph(2-Cl, 4-OCF2CF2H, 5-C2F5) Ph(2-Cl, 4-OCF2CF2H, 5-CF2CF2H) Ph(2-Cl, 4-OCF2CF2H, 5-CF2H) Ph(2-Cl, 4-OCF2CF2H, 5-OMe) Ph(2-Cl, 4-OCF2CF2H, 5-OCF3) Ph(2-Cl, 4-OCF2CF2H, 5-OCHF2) Ph(2-Cl, 4, 5-di-OCF2CF2H) Ph(2- Cl, 4-OCF2CF2H, 5-OC2F5) Ph(2-Cl, 4-OCF2CF2H, 5-SO2Me) Ph(2-Cl, 4-OCF2CF2H, 5-TMS) Ph(2-Cl, 4-OCF2CF2H, 5-CN) Ph(2-Cl, 4- OCF2CF3, 5-Cl) Ph(2-Cl, 4-OCF2CF3, 5-F) Ph(2-Cl, 4-OCF2CF3, 5-Br) Ph(2-Cl, 4-OCF2CF3, 5-I)

Ph(2-Cl, 4-OCF2CF3, 5-Me) Ph(2-Cl, 4-OCF2CF3, 5-Et) Ph(2-Cl, 4-OCF2CF3, 5-n-Pr) Ph(2-Cl, 4-OCF2CF3, 5-1-Bu) Ph(2-Cl, 4-OCF2CF3, 5- i -Pr) Ph(2-Cl, 4-OCF2CF3, 5- c -Pr) Ph(2-Cl, 4- OC2F5CF3, 5-CF3) Ph(2-Cl, 4-OCF2CF3, 5-CF2CF2H) Ph(2-Cl, 4-OCF2CF3, 5-CF2H) Ph(2-Cl, 4-OCF2CF3, 5-OMe) Ph(2-Cl, 4-OCF2CF3, 5-OCF3) Ph(2-Cl, 4-OCF2CF3, 5-OCHF2)

Q

Ph(2-Cl, 4-OCF2CF3, 5-OCF2CF2H) Ph(2-Cl, 4, 5-di-OC2F5) Ph(2-Cl, 4-OCF2CF3, 5-SO2Me) Ph(2-Cl, 4- OCF2CF3, 5-TMS) Ph(2-Cl, 4-OCF2CF3, 5-CN) Ph(2-Cl, 4-SO2Me, 5-Cl) Ph(2-Cl, 4-SO2Me, 5-F) Ph(2-Cl, 4-SO2Me, 5-Br) Ph(2-Cl, 4-SO2Me, 5-I) Ph(2-Cl, 4-SO2Me, 5-Me) Ph(2-Cl, 4-SO2Me, 5-Et) Ph(2-Cl, 4-SO2Me, 5-n-Pr) Ph(2-Cl, 4-SO2Me, 5-1-Bu) Ph(2-Cl, 4-SO2Me, 5- i - Pr) Ph(2-Cl, 4-SO2Me, 5- c -Pr) Ph(2-Cl, 4-SO2MeCF3, 5-CF3) Ph(2-Cl, 4-SO2Me, 5-C2F5) Ph(2- Cl, 4-SO2Me, 5-CF2CF2H) Ph(2-Cl, 4-SO2Me, 5-CF2H) Ph(2-Cl, 4-SO2Me, 5-OMe) Ph(2-Cl, 4-SO2Me, 5-OCF3) Ph(2-Cl, 4-SO2Me, 5-OCHF2) Ph(2-Cl, 4-SO2Me, 5-OCF2CF2H) Ph(2-Cl, 4- SO2Me, 5-OC2F5) Ph(2-Cl, 4, 5-di-SO2Me) Ph(2-Cl, 4-SO2Me, 5-TMS) Ph(2-Cl, 4-SO2Me, 5-CN) Ph(2-Cl, 4-TMS, 5-Cl) Ph(2-Cl, 4-TMS, 5-F) Ph(2-Cl, 4-TMS, 5-Br) Ph(2-Cl, 4-TMS, 5-I) Ph(2-Cl, 4-TMS, 5-Me) Ph(2-Cl, 4-TMS, 5-Et) Ph(2-Cl, 4-TMS, 5-n-Pr) Ph(2-Cl, 4-TMS, 5-1-Bu) Ph(2-Cl, 4-TMS, 5- i -Pr) Ph(2-Cl, 4-TMS, 5- c -Pr)

Q

Ph(2-Cl, 4-TMS, 5-CF3) Ph(2-Cl, 4-TMS, 5-C2F5) Ph(2-Cl, 4-TMS, 5-CF2CF2H) Ph(2-Cl, 4- TMS, 5-CF2H) Ph(2-Cl, 4-TMS, 5-OMe) Ph(2-Cl, 4-TMS, 5-OCF3) Ph(2-Cl, 4-TMS, 5-OCHF2) Ph(2-Cl, 4-TMS, 5-OCF2CF2H) Ph(2-Cl, 4-TMS, 5-OC2F5) Ph(2-Cl, 4-TMS, 5-SO2Me) Ph(2-Cl, 4, 5- di-TMS) Ph(2-Cl, 4-TMS, 5-CN) Ph(2-Cl, 4-CN, 5-Cl) Ph(2-Cl, 4-CN, 5-F) Ph(2- Cl, 4-CN, 5-Br) Ph(2-Cl, 4-CN, 5-I) Ph(2-Cl, 4-CN, 5-Me) Ph(2-Cl, 4-CN, 5- Et) Ph(2-Cl, 4-CN, 5-n-Pr) Ph(2-Cl, 4-CN, 5-1-Bu) Ph(2-Cl, 4-CN, 5- i -Pr) Ph(2-Cl, 4-CN, 5- c -Pr) Ph(2-Cl, 4-CN, 5-CF3) Ph(2-Cl, 4-CN, 5-C2F5) Ph(2-Cl, 4-CN, 5-CF2CF2H) Ph(2-Cl, 4-CN, 5-CF2H) Ph(2-Cl, 4- CN, 5-OMe) Ph(2-Cl, 4-CN, 5-OCF3) Ph(2-Cl, 4-CN, 5-OCHF2) Ph(2-Cl, 4-CN, 5-OCF2CF2H) Ph(2-Cl, 4-CN, 5-OC2F5) Ph(2-Cl, 4-CN, 5-SO2Me) Ph(2-Cl, 4-CN, 5-TMS) Ph(2-Cl, 4, 5- di-CN) Ph(2-F, 3, 4-di-Cl) Ph(2-F, 3-Cl, 4-I) Ph(2-F, 3-Cl, 4-Me)

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-Cl, 4-Et)</td><td>Ph(2-F, 3-Br, 4-CF2H)</td><td>Ph(2-F, 3-Me, 4-OC2F5)</td>

<td>Ph(2-F, 3-Cl, 4-n-Pr)</td><td>Ph(2-F, 3-Br, 4-OMe)</td><td>Ph(2-F, 3-Et, 4-Cl)</td>

<td>Ph(2-F, 3-Cl, 4- i -Pr)</td><td>Ph(2-F, 3-Br, 4-OCF2CF2H)</td><td>Ph(2-F, 3-Et, 4-F)</td>

<td>Ph(2-F, 3-Cl, 4-CF3)</td><td>Ph(2-F, 3-Br, 4-OC2F5)</td><td>Ph(2-F, 3-Et, 4-Br)</td>

<td>Ph(2-F, 3-Cl, 4-C2F5)</td><td>Ph(2-F, 3-I, 4-Cl)</td><td>Ph(2-F, 3-Et, 4-I)</td>

<td>Ph(2-F, 3-Cl, 4-CF2CF2H)</td><td>Ph(2-F, 3-I, 4-F)</td><td>Ph(2-F, 3-Et, 4-Me)</td>

<td>Ph(2-F, 3-Cl, 4-CF2H)</td><td>Ph(2-F, 3-I, 4-Br)</td><td>Ph(2-F,3,4-di-Et)</td>

<td>Ph(2-F, 3-Cl, 4-OMe)</td><td>Ph(2-F, 3, 4-di-I)</td><td>Ph(2-F, 3-Et, 4-n-Pr)</td>

<td>Ph(2-F, 3-Cl, 4-OCHF2)</td><td>Ph(2-F, 3-I, 4-Me)</td><td>Ph(2-F, 3-Et, 4-1-Bu)</td>

<td>Ph(2-F, 3-Cl, 4-OCF2CF2H)</td><td>Ph(2-F, 3-I, 4-Et)</td><td>Ph(2-F, 3-Et, 4- i -Pr)</td>

<td>Ph(2-F, 3-Cl, 4-OC2F5)</td><td>Ph(2-F, 3-I, 4-n-Pr)</td><td>Ph(2-F, 3-Et, 4- c -Pr)</td>

<td>Ph(2, 3, 4-tri-F)</td><td>Ph(2-F, 3-I, 4-1-Bu)</td><td>Ph(2-F, 3-Et, 4-CF3)</td>

<td>Ph(2-F, 3-F, 4-Br)</td><td>Ph(2-F, 3-I, 4- i -Pr)</td><td>Ph(2-F, 3-Et, 4-C2F5)</td>

<td>Ph(2-F, 3-F, 4-I)</td><td>Ph(2-F, 3-I, 4-c -Pr)</td><td>Ph(2-F, 3-Et, 4-CF2CF2H)</td>

<td>Ph(2-F, 3-F, 4-Et)</td><td>Ph(2-F, 3-I, 4-CF3)</td><td>Ph(2-F, 3-Et, 4-CF2H)</td>

<td>Ph(2-F, 3-F, 4-n-Pr)</td><td>Ph(2-F, 3-I, 4-C2F5)</td><td>Ph(2-F, 3-Et, 4-OMe)</td>

<td>Ph(2-F, 3-F, 4-1-Bu)</td><td>Ph(2-F, 3-I, 4-CF2CF2H)</td><td>Ph(2-F, 3-Et, 4-OCF3)</td>

<td>Ph(2-F, 3-F, 4- i -Pr)</td><td>Ph(2-F, 3-I, 4-CF2H)</td><td>Ph(2-F, 3-Et, 4-OCHF2)</td>

<td>Ph(2-F, 3-F, 4-CF3)</td><td>Ph(2-F, 3-I, 4-OMe)</td><td>Ph(2-F, 3-Et, 4-OCF2CF2H)</td>

<td>Ph(2-F, 3-F, 4-C2F5)</td><td>Ph(2-F, 3-I, 4-OCF3)</td><td>Ph(2-F, 3-Et, 4-OC2F5)</td>

<td>Ph(2-F, 3-F, 4-CF2CF2H)</td><td>Ph(2-F, 3-I, 4-OCHF2)</td><td>Ph(2-F, 3-Et, 4-SO2Me)</td>

<td>Ph(2-F, 3-F, 4-CF2H)</td><td>Ph(2-F, 3-I, 4-OCF2CF2H)</td><td>Ph(2-F, 3-Et, 4-TMS)</td>

<td>Ph(2-F, 3-F, 4-OMe)</td><td>Ph(2-F, 3-I, 4-OC2F5)</td><td>Ph(2-F, 3-Et, 4-CN)</td>

<td>Ph(2-F, 3-F, 4-OCHF2)</td><td>Ph(2-F, 3-I, 4-SO2Me)</td><td>Ph(2-F, 3-n-Pr, 4-Cl)</td>

<td>Ph(2-F, 3-F, 4-OCF2CF2H)</td><td>Ph(2-F, 3-I, 4-TMS)</td><td>Ph(2-F, 3-n-Pr, 4-F)</td>

<td>Ph(2-F, 3-F, 4-OC2F5)</td><td>Ph(2-F, 3-I, 4-CN)</td><td>Ph(2-F, 3-n-Pr, 4-Br)</td>

<td>Ph(2-F, 3-Br, 4-Cl)</td><td>Ph(2-F, 3-Me, 4-I)</td><td>Ph(2-F, 3-n-Pr, 4-I)</td>

<td>Ph(2-F, 3, 4-di-Br)</td><td>Ph(2-F, 3, 4-di-Me)</td><td>Ph(2-F, 3-n-Pr, 4-Me)</td>

<td>Ph(2-F, 3-Br, 4-I)</td><td>Ph(2-F, 3-Me, 4-Et)</td><td>Ph(2-F, 3-n-Pr, 4-Et)</td>

<td>Ph(2-F, 3-Br, 4-Me)</td><td>Ph(2-F, 3-Me, 4-n-Pr)</td><td>Ph(2-F, 3, 4-di-n-Pr)</td>

<td>Ph(2-F, 3-Br, 4-Et)</td><td>Ph(2-F, 3-Me, 4-i -Pr)</td><td>Ph(2-F, 3-n-Pr, 4-1-Bu)</td>

<td>Ph(2-F, 3-Br, 4-n-Pr)</td><td>Ph(2-F, 3-Me, 4-c -Pr)</td><td>Ph(2-F, 3- n -Pr, 4- i -Pr)</td>

<td>Ph(2-F, 3-Br, 4-1-Bu)</td><td>Ph(2-F, 3-Me, 4-C2F5)</td><td>Ph(2-F, 3-n-Pr, 4-c-Pr)</td>

<td>Ph(2-F, 3-Br, 4- i -Pr)</td><td>Ph(2-F, 3-Me, 4-CF2CF2H)</td><td>Ph(2-F, 3-n-Pr, 4-CF3)</td>

<td>Ph(2-F, 3-Br, 4-CF3)</td><td>Ph(2-F, 3-Me, 4-CF2H)</td><td>Ph(2-F, 3-n-Pr, 4-C2F5)</td>

<td>Ph(2-F, 3-Br, 4-C2F5)</td><td>Ph(2-F, 3-Me, 4-OMe)</td><td>Ph(2-F, 3-n-Pr, 4-CF2CF2H)</td>

<td>Ph(2-F, 3-Br, 4-CF2CF2H)</td><td>Ph(2-F, 3-Me, 4-OCF2CF2H)</td><td>Ph(2-F, 3-n-Pr, 4-CF2H)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>62 Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-n-Pr, 4-OMe)</td><td>Ph(2-F, 3- i -Pr, 4-OC2F5)</td><td>Ph(2-F, 3-C2F5, 4- i -Pr)</td>

<td>Ph(2-F, 3-n-Pr, 4-OCF3)</td><td>Ph(2-F, 3- i -Pr, 4-SO2Me)</td><td>Ph(2-F, 3-C2F5, 4- c -Pr)</td>

<td>Ph(2-F, 3-n-Pr, 4-OCHF2)</td><td>Ph(2-F, 3- i -Pr, 4-TMS)</td><td>Ph(2-F, 3-C2F5CF3, 4-CF3)</td>

<td>Ph(2-F, 3-n-Pr, 4-OCF2CF2H)</td><td>Ph(2-F, 3- i -Pr, 4-CN)</td><td>Ph(2-F,3,4-di-C2F5)</td>

<td>Ph(2-F, 3-n-Pr, 4-OC2F5)</td><td>Ph(2-F, 3- c -Pr, 4-I)</td><td>Ph(2-F, 3-C2F5, 4-CF2CF2H)</td>

<td>Ph(2-F, 3-n-Pr, 4-SO2Me)</td><td>Ph(2-F, 3- c -Pr, 4-Et)</td><td>Ph(2-F, 3-C2F5, 4-CF2H)</td>

<td>Ph(2-F, 3-n-Pr, 4-TMS)</td><td>Ph(2-F, 3-c-Pr, 4-n-Pr)</td><td>Ph(2-F, 3-C2F5, 4-OMe)</td>

<td>Ph(2-F, 3-n-Pr, 4-CN)</td><td>Ph(2-F, 3- c -Pr, 4- i -Pr)</td><td>Ph(2-F, 3-C2F5, 4-OCF3)</td>

<td>Ph(2-F, 3-1-Bu, 4-I)</td><td>Ph(2-F, 3- c -Pr, 4-C2F5)</td><td>Ph(2-F, 3-C2F5, 4-OCHF2)</td>

<td>Ph(2-F, 3-1-Bu, 4-Et)</td><td>Ph(2-F, 3- c -Pr, 4-CF2CF2H)</td><td>Ph(2-F, 3-C2F5, 4-OCF2CF2H)</td>

<td>Ph(2-F, 3-1-Bu, 4-n-Pr)</td><td>Ph(2-F, 3- c -Pr, 4-CF2H)</td><td>Ph(2-F, 3-C2F5, 4-OC2F5)</td>

<td>Ph(2-F, 3, 4-di-1-Bu)</td><td>Ph(2-F, 3- c -Pr, 4-OMe)</td><td>Ph(2-F, 3-C2F5, 4-SO2Me)</td>

<td>Ph(2-F, 3-1-Bu, 4- i -Pr)</td><td>Ph(2-F, 3- c -Pr, 4-OCF2CF2H)</td><td>Ph(2-F, 3-C2F5, 4-TMS)</td>

<td>Ph(2-F, 3-1-Bu, 4-C2F5)</td><td>Ph(2-F, 3- c -Pr, 4-OC2F5)</td><td>Ph(2-F, 3-C2F5, 4-CN)</td>

<td>Ph(2-F, 3-1-Bu, 4-CF2CF2H)</td><td>Ph(2-F, 3-CF3, 4-I)</td><td>Ph(2-F, 3-CF2CF2H, 4-Cl)</td>

<td>Ph(2-F, 3-1-Bu, 4-CF2H)</td><td>Ph(2-F, 3-CF3, 4-Et)</td><td>Ph(2-F, 3-CF2CF2H, 4-F)</td>

<td>Ph(2-F, 3-1-Bu, 4-OMe)</td><td>Ph(2-F, 3-CF3, 4-n-Pr)</td><td>Ph(2-F, 3-CF2CF2H, 4-Br)</td>

<td>Ph(2-F, 3-1-Bu, 4-OCF2CF2H)</td><td>Ph(2-F, 3-CF3, 4- i -Pr)</td><td>Ph(2-F, 3-CF2CF2H, 4-I)</td>

<td>Ph(2-F, 3-1-Bu, 4-OC2F5)</td><td>Ph(2-F,3,4-di-CF3)</td><td>Ph(2-F, 3-CF2CF2H, 4-Me)</td>

<td>Ph(2-F, 3- i -Pr, 4-Cl)</td><td>Ph(2-F, 3-CF3, 4-C2F5)</td><td>Ph(2-F, 3-CF2CF2H, 4-Et)</td>

<td>Ph(2-F, 3- i -Pr, 4-F)</td><td>Ph(2-F, 3-CF3, 4-CF2CF2H)</td><td>Ph(2-F, 3-CF2CF2H, 4-n-Pr)</td>

<td>Ph(2-F, 3- i -Pr, 4-Br)</td><td>Ph(2-F, 3-CF3, 4-CF2H)</td><td>Ph(2-F, 3-CF2CF2H, 4-1-Bu)</td>

<td>Ph(2-F, 3- i -Pr, 4-I)</td><td>Ph(2-F, 3-CF3, 4-OMe)</td><td>Ph(2-F, 3-CF2CF2H, 4- i -Pr)</td>

<td>Ph(2-F, 3- i -Pr, 4-Me)</td><td>Ph(2-F, 3-CF3, 4-OCF3)</td><td>Ph(2-F, 3-CF2CF2H, 4- c -Pr)</td>

<td>Ph(2-F, 3- i -Pr, 4-Et)</td><td>Ph(2-F, 3-CF3, 4-OCHF2)</td><td>Ph(2-F, 3-CF2CF2H, 4-CF3)</td>

<td>Ph(2-F, 3- i -Pr, 4-n-Pr)</td><td>Ph(2-F, 3-CF3, 4-OCF2CF2H)</td><td>Ph(2-F, 3-CF2CF2H, 4-C2F5)</td>

<td>Ph(2-F, 3- i -Pr, 4-1-Bu)</td><td>Ph(2-F, 3-CF3, 4-OC2F5)</td><td>Ph(2-F,3,4-di-CF2CF2H)</td>

<td>Ph(2-F, 3, 4-di-i-Pr)</td><td>Ph(2-F, 3-CF3, 4-TMS)</td><td>Ph(2-F, 3-CF2CF2H, 4-CF2H)</td>

<td>Ph(2-F, 3- i -Pr, 4- c -Pr)</td><td>Ph(2-F, 3-CF3, 4-CN)</td><td>Ph(2-F, 3-CF2CF2H, 4-OMe)</td>

<td>Ph(2-F, 3- i -Pr, 4-CF3)</td><td>Ph(2-F, 3-C2F5, 4-Cl)</td><td>Ph(2-F, 3-CF2CF2H, 4-OCF3)</td>

<td>Ph(2-F, 3- i -Pr, 4-C2F5)</td><td>Ph(2-F, 3-C2F5, 4-F)</td><td>Ph(2-F, 3-CF2CF2H, 4-OCHF2)</td>

<td>Ph(2-F, 3- i -Pr, 4-CF2CF2H)</td><td>Ph(2-F, 3-C2F5, 4-Br)</td><td>Ph(2-F, 3-CF2CF2H, 4-OCF2CF2H)</td>

<td>Ph(2-F, 3- i -Pr, 4-CF2H)</td><td>Ph(2-F, 3-C2F5, 4-I)</td><td>Ph(2-F, 3-CF2CF2H, 4-OC2F5)</td>

<td>Ph(2-F, 3- i -Pr, 4-OMe)</td><td>Ph(2-F, 3-C2F5, 4-Me)</td><td>Ph(2-F, 3-CF2CF2H, 4-SO2Me)</td>

<td>Ph(2-F, 3- i -Pr, 4-OCF3)</td><td>Ph(2-F, 3-C2F5, 4-Et)</td><td>Ph(2-F, 3-CF2CF2H, 4-TMS)</td>

<td>Ph(2-F, 3- i -Pr, 4-OCHF2)</td><td>Ph(2-F, 3-C2F5, 4-n-Pr)</td><td>Ph(2-F, 3-CF2CF2H, 4-CN)</td>

<td>Ph(2-F, 3- i -Pr, 4-OCF2CF2H)</td><td>Ph(2-F, 3-C2F5, 4-1-Bu)</td><td>Ph(2-F, 3-CF2H, 4-Cl)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-CF2H, 4-F)</td><td>Ph(2-F, 3-OMe, 4-OCHF2)</td><td>Ph(2-F, 3-OCHF2, 4-OMe)</td>

<td>Ph(2-F, 3-CF2H, 4-Br)</td><td>Ph(2-F, 3-OMe, 4-OCF2CF2H)</td><td>Ph(2-F, 3-OCHF2, 4-OCF3)</td>

<td>Ph(2-F, 3-CF2H, 4-I)</td><td>Ph(2-F, 3-OMe, 4-OC2F5)</td><td>Ph(2-F, 3, 4-di-OCHF2)</td>

<td>Ph(2-F, 3-CF2H, 4-Me)</td><td>Ph(2-F, 3-OMe, 4-SO2Me)</td><td>Ph(2-F, 3-OCHF2, 4-OCF2CF2H)</td>

<td>Ph(2-F, 3-CF2H, 4-Et)</td><td>Ph(2-F, 3-OMe, 4-TMS)</td><td>Ph(2-F, 3-OCHF2, 4-OC2F5)</td>

<td>Ph(2-F, 3-CF2H, 4-n-Pr)</td><td>Ph(2-F, 3-OMe, 4-CN)</td><td>Ph(2-F, 3-OCHF2, 4-SO2Me)</td>

<td>Ph(2-F, 3-CF2H, 4-1-Bu)</td><td>Ph(2-F, 3-OCF3, 4-Cl)</td><td>Ph(2-F, 3-OCHF2, 4-TMS)</td>

<td>Ph(2-F, 3-CF2H, 4- i -Pr)</td><td>Ph(2-F, 3-OCF3, 4-F)</td><td>Ph(2-F, 3-OCHF2, 4-CN)</td>

<td>Ph(2-F, 3-CF2H, 4- c -Pr)</td><td>Ph(2-F, 3-OCF3, 4-Br)</td><td>Ph(2-F, 3-OCF2CF2H, 4-Cl)</td>

<td>Ph(2-F, 3-CF2H, 4-CF3)</td><td>Ph(2-F, 3-OCF3, 4-I)</td><td>Ph(2-F, 3-OCF2CF2H, 4-F)</td>

<td>Ph(2-F, 3-CF2H, 4-C2F5)</td><td>Ph(2-F, 3-OCF3, 4-Me)</td><td>Ph(2-F, 3-OCF2CF2H, 4-Br)</td>

<td>Ph(2-F, 3-CF2H, 4-CF2CF2H)</td><td>Ph(2-F, 3-OCF3, 4-Et)</td><td>Ph(2-F, 3-OCF2CF2H, 4-I)</td>

<td>Ph(2-F,3,4-di-CF2H)</td><td>Ph(2-F, 3-OCF3, 4-n-Pr)</td><td>Ph(2-F, 3-OCF2CF2H, 4-Me)</td>

<td>Ph(2-F, 3-CF2H, 4-OMe)</td><td>Ph(2-F, 3-OCF3, 4-1-Bu)</td><td>Ph(2-F, 3-OCF2CF2H, 4-Et)</td>

<td>Ph(2-F, 3-CF2H, 4-OCF3)</td><td>Ph(2-F, 3-OCF3, 4- i -Pr)</td><td>Ph(2-F, 3-OCF2CF2H, 4-n-Pr)</td>

<td>Ph(2-F, 3-CF2H, 4-OCHF2)</td><td>Ph(2-F, 3-OCF3, 4-CF3)</td><td>Ph(2-F, 3-OCF2CF2H, 4-1-Bu)</td>

<td>Ph(2-F, 3-CF2H, 4-OCF2CF2H)</td><td>Ph(2-F, 3-OCF3, 4-C2F5)</td><td>Ph(2-F, 3-OCF2CF2H, 4- i -Pr)</td>

<td>Ph(2-F, 3-CF2H, 4-OC2F5)</td><td>Ph(2-F, 3-OCF3, 4-CF2CF2H)</td><td>Ph(2-F, 3-OCF2CF2H, 4- c -Pr)</td>

<td>Ph(2-F, 3-CF2H, 4-SO2Me)</td><td>Ph(2-F, 3-OCF3, 4-CF2H)</td><td>Ph(2-F, 3-OCF2CF2H, 4-CF3)</td>

<td>Ph(2-F, 3-CF2H, 4-TMS)</td><td>Ph(2-F, 3-OCF3, 4-OMe)</td><td>Ph(2-F, 3-OCF2CF2H, 4-C2F5)</td>

<td>Ph(2-F, 3-CF2H, 4-CN)</td><td>Ph(2-F,3,4-di-OCF3)</td><td>Ph(2-F, 3-OCF2CF2H, 4-CF2CF2H)</td>

<td>Ph(2-F, 3-OMe, 4-Cl)</td><td>Ph(2-F, 3-OCF3, 4-OCF2CF2H)</td><td>Ph(2-F, 3-OCF2CF2H, 4-CF2H)</td>

<td>Ph(2-F, 3-OMe, 4-F)</td><td>Ph(2-F, 3-OCF3, 4-OC2F5)</td><td>Ph(2-F, 3-OCF2CF2H, 4-OMe)</td>

<td>Ph(2-F, 3-OMe, 4-Br)</td><td>Ph(2-F, 3-OCHF2, 4-Cl)</td><td>Ph(2-F, 3-OCF2CF2H, 4-OCF3)</td>

<td>Ph(2-F, 3-OMe, 4-I)</td><td>Ph(2-F, 3-OCHF2, 4-F)</td><td>Ph(2-F, 3-OCF2CF2H, 4-OCHF2)</td>

<td>Ph(2-F, 3-OMe, 4-Me)</td><td>Ph(2-F, 3-OCHF2, 4-Br)</td><td>Ph(2-F,3,4-di-OCF2CF2H)</td>

<td>Ph(2-F, 3-OMe, 4-Et)</td><td>Ph(2-F, 3-OCHF2, 4-I)</td><td>Ph(2-F, 3-OCF2CF2H, 4-OC2F5)</td>

<td>Ph(2-F, 3-OMe, 4-n-Pr)</td><td>Ph(2-F, 3-OCHF2, 4-Me)</td><td>Ph(2-F, 3-OCF2CF2H, 4-SO2Me)</td>

<td>Ph(2-F, 3-OMe, 4-1-Bu)</td><td>Ph(2-F, 3-OCHF2, 4-Et)</td><td>Ph(2-F, 3-OCF2CF2H, 4-TMS)</td>

<td>Ph(2-F, 3-OMe, 4- i -Pr)</td><td>Ph(2-F, 3-OCHF2, 4-n-Pr)</td><td>Ph(2-F, 3-OCF2CF2H, 4-CN)</td>

<td>Ph(2-F, 3-OMe, 4- c -Pr)</td><td>Ph(2-F, 3-OCHF2, 4-1-Bu)</td><td>Ph(2-F, 3-OC2F5, 4-Cl)</td>

<td>Ph(2-F, 3-OMe, 4-CF3)</td><td>Ph(2-F, 3-OCHF2, 4- i -Pr)</td><td>Ph(2-F, 3-OC2F5, 4-F)</td>

<td>Ph(2-F, 3-OMe, 4-C2F5)</td><td>Ph(2-F, 3-OCHF2, 4- c -Pr)</td><td>Ph(2-F, 3-OC2F5, 4-Br)</td>

<td>Ph(2-F, 3-OMe, 4-CF2CF2H)</td><td>Ph(2-F, 3-OCHF2CF3, 4-CF3)</td><td>Ph(2-F, 3-OC2F5, 4-I)</td>

<td>Ph(2-F, 3-OMe, 4-CF2H)</td><td>Ph(2-F, 3-OC2F5, 4-C2F5)</td><td>Ph(2-F, 3-OC2F5, 4-Me)</td>

<td>Ph(2-F, 3, 4-di-OMe)</td><td>Ph(2-F, 3-OCHF2, 4-CF2CF2H)</td><td>Ph(2-F, 3-OC2F5, 4-Et)</td>

<td>Ph(2-F, 3-OMe, 4-OCF3)</td><td>Ph(2-F, 3-OCHF2, 4-CF2H)</td><td>Ph(2-F, 3-OC2F5, 4-n-Pr)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-OC2F5, 4-1-Bu)</td><td>Ph(2-F, 3-TMS, 4-1-Bu)</td><td>Ph(2-F, 3-Cl, 5-Br)</td>

<td>Ph(2-F, 3-OC2F5, 4-i -Pr)</td><td>Ph(2-F, 3-TMS, 4- i -Pr)</td><td>Ph(2-F, 3-Cl, 5-I)</td>

<td>Ph(2-F, 3-OC2F5, 4-c -Pr)</td><td>Ph(2-F, 3-TMS, 4- c -Pr)</td><td>Ph(2-F, 3-Cl, 5-Me)</td>

<td>Ph(2-F, 3-OC2F5CF3, 4-CF3)</td><td>Ph(2-F, 3-TMS, 4-CF3)</td><td>Ph(2-F, 3-Cl, 5-Et)</td>

<td>Ph(2-F, 3-OC2F5, 4-CF2CF2H)</td><td>Ph(2-F, 3-TMS, 4-C2F5)</td><td>Ph(2-F, 3-Cl, 5-n-Pr)</td>

<td>Ph(2-F, 3-OC2F5, 4-CF2H)</td><td>Ph(2-F, 3-TMS, 4-CF2CF2H)</td><td>Ph(2-F, 3-Cl, 5-1-Bu)</td>

<td>Ph(2-F, 3-OC2F5, 4-OMe)</td><td>Ph(2-F, 3-TMS, 4-CF2H)</td><td>Ph(2-F, 3-Cl, 5- i -Pr)</td>

<td>Ph(2-F, 3-OC2F5, 4-OCF3)</td><td>Ph(2-F, 3-TMS, 4-OMe)</td><td>Ph(2-F, 3-Cl, 5- c -Pr)</td>

<td>Ph(2-F, 3-OC2F5, 4-OCHF2)</td><td>Ph(2-F, 3-TMS, 4-OCF3)</td><td>Ph(2-F, 3-Cl, 5-CF3)</td>

<td>Ph(2-F, 3-OC2F5, 4-OCF2CF2H)</td><td>Ph(2-F, 3-TMS, 4-OCHF2)</td><td>Ph(2-F, 3-Cl, 5-C2F5)</td>

<td>Ph(2-F,3,4-di-OC2F5)</td><td>Ph(2-F, 3-TMS, 4-OCF2CF2H)</td><td>Ph(2-F, 3-Cl, 5-CF2CF2H)</td>

<td>Ph(2-F, 3-OC2F5, 4-SO2Me)</td><td>Ph(2-F, 3-TMS, 4-OC2F5)</td><td>Ph(2-F, 3-Cl, 5-CF2H)</td>

<td>Ph(2-F, 3-OC2F5, 4-TMS)</td><td>Ph(2-F, 3-TMS, 4-SO2Me)</td><td>Ph(2-F, 3-Cl, 5-OMe)</td>

<td>Ph(2-F, 3-OC2F5, 4-CN)</td><td>Ph(2-F,3,4-di-TMS)</td><td>Ph(2-F, 3-Cl, 5-OCF3)</td>

<td>Ph(2-F, 3-SO2Me, 4-Cl)</td><td>Ph(2-F, 3-TMS, 4-CN)</td><td>Ph(2-F, 3-Cl, 5-OCHF2)</td>

<td>Ph(2-F, 3-SO2Me, 4-Br)</td><td>Ph(2-F, 3-CN, 4-F)</td><td>Ph(2-F, 3-Cl, 5-OCF2CF2H)</td>

<td>Ph(2-F, 3-SO2Me, 4-I)</td><td>Ph(2-F, 3-CN, 4-Br)</td><td>Ph(2-F, 3-Cl, 5-OC2F5)</td>

<td>Ph(2-F, 3-SO2Me, 4-Me)</td><td>Ph(2-F, 3-CN, 4-I)</td><td>Ph(2-F, 3-Cl, 5-SO2Me)</td>

<td>Ph(2-F, 3-SO2Me, 4-Et)</td><td>Ph(2-F, 3-CN, 4-Me)</td><td>Ph(2-F, 3-Cl, 5-TMS)</td>

<td>Ph(2-F, 3-SO2Me, 4-n-Pr)</td><td>Ph(2-F, 3-CN, 4-Et)</td><td>Ph(2-F, 3-Cl, 5-CN)</td>

<td>Ph(2-F, 3-SO2Me, 4-1-Bu)</td><td>Ph(2-F, 3-CN, 4-n-Pr)</td><td>Ph(2-F, 3-F, 5-Cl)</td>

<td>Ph(2-F, 3-SO2Me, 4- i -Pr)</td><td>Ph(2-F, 3-CN, 4-1-Bu)</td><td>Ph(2, 3, 5-tri-F)</td>

<td>Ph(2-F, 3-SO2MeCF3, 4-CF3)</td><td>Ph(2-F, 3-CN, 4- i -Pr)</td><td>Ph(2-F, 3-F, 5-Br)</td>

<td>Ph(2-F, 3-SO2Me, 4-C2F5)</td><td>Ph(2-F, 3-CN, 4- c -Pr)</td><td>Ph(2-F, 3-F, 5-I)</td>

<td>Ph(2-F, 3-SO2Me, 4-CF2CF2H)</td><td>Ph(2-F, 3-CN, 4-CF3)</td><td>Ph(2-F, 3-F, 5-Me)</td>

<td>Ph(2-F, 3-SO2Me, 4-CF2H)</td><td>Ph(2-F, 3-CN, 4-C2F5)</td><td>Ph(2-F, 3-F, 5-Et)</td>

<td>Ph(2-F, 3-SO2Me, 4-OMe)</td><td>Ph(2-F, 3-CN, 4-CF2CF2H)</td><td>Ph(2-F, 3-F, 5-n-Pr)</td>

<td>Ph(2-F, 3-SO2Me, 4-OCHF2)</td><td>Ph(2-F, 3-CN, 4-CF2H)</td><td>Ph(2-F, 3-F, 5-1-Bu)</td>

<td>Ph(2-F, 3-SO2Me, 4-OCF2CF2H)</td><td>Ph(2-F, 3-CN, 4-OMe)</td><td>Ph(2-F, 3-F, 5- i -Pr)</td>

<td>Ph(2-F, 3-SO2Me, 4-OC2F5)</td><td>Ph(2-F, 3-CN, 4-OCF3)</td><td>Ph(2-F, 3-F, 5- c -Pr)</td>

<td>Ph(2-F, 3-TMS, 4-Cl)</td><td>Ph(2-F, 3-CN, 4-OCHF2)</td><td>Ph(2-F, 3-F, 5-CF3)</td>

<td>Ph(2-F, 3-TMS, 4-F)</td><td>Ph(2-F, 3-CN, 4-OCF2CF2H)</td><td>Ph(2-F, 3-F, 5-C2F5)</td>

<td>Ph(2-F, 3-TMS, 4-Br)</td><td>Ph(2-F, 3-CN, 4-OC2F5)</td><td>Ph(2-F, 3-F, 5-CF2CF2H)</td>

<td>Ph(2-F, 3-TMS, 4-I)</td><td>Ph(2-F, 3-CN, 4-TMS)</td><td>Ph(2-F, 3-F, 5-CF2H)</td>

<td>Ph(2-F, 3-TMS, 4-Me)</td><td>Ph(2-F, 3, 4-di-CN)</td><td>Ph(2-F, 3-F, 5-OMe)</td>

<td>Ph(2-F, 3-TMS, 4-Et)</td><td>Ph(2-F,3,5-di-Cl)</td><td>Ph(2-F, 3-F, 5-OCF3)</td>

<td>Ph(2-F, 3-TMS, 4-n-Pr)</td><td>Ph(2-F, 3-Cl, 5-F)</td><td>Ph(2-F, 3-F, 5-OCHF2)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-F, 5-OCF2CF2H)</td><td>Ph(2-F, 3-I, 5-CF3)</td><td>Ph(2-F, 3-Et, 5-I)</td>

<td>Ph(2-F, 3-F, 5-OC2F5)</td><td>Ph(2-F, 3-I, 5-C2F5)</td><td>Ph(2-F, 3-Et, 5-Me)</td>

<td>Ph(2-F, 3-F, 5-SO2Me)</td><td>Ph(2-F, 3-I, 5-CF2CF2H)</td><td>Ph(2-F,3,5-di-Et)</td>

<td>Ph(2-F, 3-F, 5-TMS)</td><td>Ph(2-F, 3-I, 5-CF2H)</td><td>Ph(2-F, 3-Et, 5-n-Pr)</td>

<td>Ph(2-F, 3-F, 5-CN)</td><td>Ph(2-F, 3-I, 5-OMe)</td><td>Ph(2-F, 3-Et, 5-1-Bu)</td>

<td>Ph(2-F, 3-Br, 5-Cl)</td><td>Ph(2-F, 3-I, 5-OCF3)</td><td>Ph(2-F, 3-Et, 5- i -Pr)</td>

<td>Ph(2-F, 3-Br, 5-F)</td><td>Ph(2-F, 3-I, 5-OCHF2)</td><td>Ph(2-F, 3-Et, 5- c -Pr)</td>

<td>Ph(2-F,3,5-di-Br)</td><td>Ph(2-F, 3-I, 5-OCF2CF2H)</td><td>Ph(2-F, 3-Et, 5-CF3)</td>

<td>Ph(2-F, 3-Br, 5-I)</td><td>Ph(2-F, 3-I, 5-OC2F5)</td><td>Ph(2-F, 3-Et, 5-C2F5)</td>

<td>Ph(2-F, 3-Br, 5-Me)</td><td>Ph(2-F, 3-I, 5-SO2Me)</td><td>Ph(2-F, 3-Et, 5-CF2CF2H)</td>

<td>Ph(2-F, 3-Br, 5-Et)</td><td>Ph(2-F, 3-I, 5-TMS)</td><td>Ph(2-F, 3-Et, 5-CF2H)</td>

<td>Ph(2-F, 3-Br, 5-n-Pr)</td><td>Ph(2-F, 3-I, 5-CN)</td><td>Ph(2-F, 3-Et, 5-OMe)</td>

<td>Ph(2-F, 3-Br, 5-1-Bu)</td><td>Ph(2-F, 3-Me, 5-Cl)</td><td>Ph(2-F, 3-Et, 5-OCF3)</td>

<td>Ph(2-F, 3-Br, 5- i -Pr)</td><td>Ph(2-F, 3-Me, 5-F)</td><td>Ph(2-F, 3-Et, 5-OCHF2)</td>

<td>Ph(2-F, 3-Br, 5- c -Pr)</td><td>Ph(2-F, 3-Me, 5-Br)</td><td>Ph(2-F, 3-Et, 5-OCF2CF2H)</td>

<td>Ph(2-F, 3-Br, 5-CF3)</td><td>Ph(2-F, 3-Me, 5-I)</td><td>Ph(2-F, 3-Et, 5-OC2F5)</td>

<td>Ph(2-F, 3-Br, 5-C2F5)</td><td>Ph(2-F, 3, 5-di-Me)</td><td>Ph(2-F, 3-Et, 5-SO2Me)</td>

<td>Ph(2-F, 3-Br, 5-CF2CF2H)</td><td>Ph(2-F, 3-Me, 5-Et)</td><td>Ph(2-F, 3-Et, 5-TMS)</td>

<td>Ph(2-F, 3-Br, 5-CF2H)</td><td>Ph(2-F, 3-Me, 5-n-Pr)</td><td>Ph(2-F, 3-Et, 5-CN)</td>

<td>Ph(2-F, 3-Br, 5-OMe)</td><td>Ph(2-F, 3-Me, 5-t-Bu)</td><td>Ph(2-F, 3-n-Pr, 5-Cl)</td>

<td>Ph(2-F, 3-Br, 5-OCF3)</td><td>Ph(2-F, 3-Me, 5-i -Pr)</td><td>Ph(2-F, 3-n-Pr, 5-F)</td>

<td>Ph(2-F, 3-Br, 5-OCHF2)</td><td>Ph(2-F, 3-Me, 5-c -Pr)</td><td>Ph(2-F, 3-n-Pr, 5-Br)</td>

<td>Ph(2-F, 3-Br, 5-OCF2CF2H)</td><td>Ph(2-F, 3-Me, 5-CF3)</td><td>Ph(2-F, 3-n-Pr, 5-I)</td>

<td>Ph(2-F, 3-Br, 5-OC2F5)</td><td>Ph(2-F, 3-Me, 5-C2F5)</td><td>Ph(2-F, 3-n-Pr, 5-Me)</td>

<td>Ph(2-F, 3-Br, 5-SO2Me)</td><td>Ph(2-F, 3-Me, 5-CF2CF2H)</td><td>Ph(2-F, 3-n-Pr, 5-Et)</td>

<td>Ph(2-F, 3-Br, 5-TMS)</td><td>Ph(2-F, 3-Me, 5-CF2H)</td><td>Ph(2-F, 3, 5-di-n-Pr)</td>

<td>Ph(2-F, 3-Br, 5-CN)</td><td>Ph(2-F, 3-Me, 5-OMe)</td><td>Ph(2-F, 3-n-Pr, 5-1-Bu)</td>

<td>Ph(2-F, 3-I, 5-Cl)</td><td>Ph(2-F, 3-Me, 5-OCF3)</td><td>Ph(2-F, 3- n -Pr, 5- i -Pr)</td>

<td>Ph(2-F, 3-I, 5-F)</td><td>Ph(2-F, 3-Me, 5-OCHF2)</td><td>Ph(2-F, 3-n-Pr, 5-c-Pr)</td>

<td>Ph(2-F, 3-I, 5-Br)</td><td>Ph(2-F, 3-Me, 5-OCF2CF2H)</td><td>Ph(2-F, 3-n-Pr, 5-CF3)</td>

<td>Ph(2-F, 3, 5-di-I)</td><td>Ph(2-F, 3-Me, 5-OC2F5)</td><td>Ph(2-F, 3-n-Pr, 5-C2F5)</td>

<td>Ph(2-F, 3-I, 5-Me)</td><td>Ph(2-F, 3-Me, 5-SO2Me)</td><td>Ph(2-F, 3-n-Pr, 5-CF2CF2H)</td>

<td>Ph(2-F, 3-I, 5-Et)</td><td>Ph(2-F, 3-Me, 5-TMS)</td><td>Ph(2-F, 3-n-Pr, 5-CF2H)</td>

<td>Ph(2-F, 3-I, 5-n-Pr)</td><td>Ph(2-F, 3-Me, 5-CN)</td><td>Ph(2-F, 3-n-Pr, 5-OMe)</td>

<td>Ph(2-F, 3-I, 5-1-Bu)</td><td>Ph(2-F, 3-Et, 5-Cl)</td><td>Ph(2-F, 3-n-Pr, 5-OCF3)</td>

<td>Ph(2-F, 3-I, 5- i -Pr)</td><td>Ph(2-F, 3-Et, 5-F)</td><td>Ph(2-F, 3-n-Pr, 5-OCHF2)</td>

<td>Ph(2-F, 3-I, 5-c -Pr)</td><td>Ph(2-F, 3-Et, 5-Br)</td><td>Ph(2-F, 3-n-Pr, 5-OCF2CF2H)</td>

MD 4889 B1 2024.03.31

<td rowspan="2">Q¹</td><td colspan="2"> 66</td>

<td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 3-n-Pr, 5-OC2F5)</td><td>Ph(2-F, 3- i -Pr, 5-C2F5)</td><td>Ph(2-F, 3-CF3, 5-Me)</td>

<td>Ph(2-F, 3-n-Pr, 5-SO2Me)</td><td>Ph(2-F, 3- i -Pr, 5-CF2CF2H)</td><td>Ph(2-F, 3-CF3, 5-Et)</td>

<td>Ph(2-F, 3-n-Pr, 5-TMS)</td><td>Ph(2-F, 3- i -Pr, 5-CF2H)</td><td>Ph(2-F, 3-CF3, 5-n-Pr)</td>

<td>Ph(2-F, 3-n-Pr, 5-CN)</td><td>Ph(2-F, 3- i -Pr, 5-OMe)</td><td>Ph(2-F, 3-CF3, 5-1-Bu)</td>

<td>Ph(2-F, 3-1-Bu, 5-Cl)</td><td>Ph(2-F, 3- i -Pr, 5-OCF3)</td><td>Ph(2-F, 3-CF3, 5- i -Pr)</td>

<td>Ph(2-F, 3-1-Bu, 5-F)</td><td>Ph(2-F, 3- i -Pr, 5-OCHF2)</td><td>Ph(2-F, 3-CF3, 5-c -Pr)</td>

<td>Ph(2-F, 3-1-Bu, 5-Br)</td><td>Ph(2-F, 3- i -Pr, 5-OCF2CF2H)</td><td>Ph(2-F, 3, 5-di-CF3)</td>

<td>Ph(2-F, 3-1-Bu, 5-I)</td><td>Ph(2-F, 3- i -Pr, 5-OC2F5)</td><td>Ph(2-F, 3-CF3, 5-C2F5)</td>

<td>Ph(2-F, 3-1-Bu, 5-Me)</td><td>Ph(2-F, 3- i -Pr, 5-SO2Me)</td><td>Ph(2-F, 3-CF3, 5-CF2CF2H)</td>

<td>Ph(2-F, 3-1-Bu, 5-Et)</td><td>Ph(2-F, 3- i -Pr, 5-TMS)</td><td>Ph(2-F, 3-CF3, 5-CF2H)</td>

<td>Ph(2-F, 3-1-Bu, 5-n-Pr)</td><td>Ph(2-F, 3- i -Pr, 5-CN)</td><td>Ph(2-F, 3-CF3, 5-OMe)</td>

<td>Ph(2-F,3,5-di-1-Bu)</td><td>Ph(2-F, 3- c -Pr, 5-Cl)</td><td>Ph(2-F, 3-CF3, 5-OCF3)</td>

<td>Ph(2-F, 3-1-Bu, 5- i -Pr)</td><td>Ph(2-F, 3- c -Pr, 5-F)</td><td>Ph(2-F, 3-CF3, 5-OCHF2)</td>

<td>Ph(2-F, 3-1-Bu, 5- c -Pr)</td><td>Ph(2-F, 3- c -Pr, 5-Br)</td><td>Ph(2-F, 3-CF3, 5-OCF2CF2H)</td>

<td>Ph(2-F, 3-1-Bu, 5-CF3)</td><td>Ph(2-F, 3- c -Pr, 5-I)</td><td>Ph(2-F, 3-CF3, 5-OC2F5)</td>

<td>Ph(2-F, 3-1-Bii, 5-CT.)</td><td>Ph(2-F, 3- c -Pr, 5-Me)</td><td>Ph(2-F, 3-CF3, 5-SO2Me)</td>

<td>Ph(2-F, 3-1-Bu, 5-CF2CF2H)</td><td>Ph(2-F, 3- c -Pr, 5-Et)</td><td>Ph(2-F, 3-CF3, 5-TMS)</td>

<td>Ph(2-F, 3-1-Bu, 5-CF2H)</td><td>Ph(2-F, 3-c-Pr, 5-n-Pr)</td><td>Ph(2-F, 3-CF3, 5-CN)</td>

<td>Ph(2-F, 3-1-Bu, 5-OMe)</td><td>Ph(2-F, 3- c -Pr, 5-1-Bu)</td><td>Ph(2-F, 3-C2F5, 5-Cl)</td>

<td>Ph(2-F, 3-1-Bu, 5-OCF3)</td><td>Ph(2-F, 3- c -Pr, 5- i -Pr)</td><td>Ph(2-F, 3-C2F5, 5-F)</td>

<td>Ph(2-F, 3-1-Bu, 5-OCHF2)</td><td>Ph(2-F, 3, 5-di-c-Pr)</td><td>Ph(2-F, 3-C2F5, 5-Br)</td>

<td>Ph(2-F, 3-1-Bu, 5-OCF2CF2H)</td><td>Ph(2-F, 3- c -Pr, 5-CF3)</td><td>Ph(2-F, 3-C2F5, 5-I)</td>

<td>Ph(2-F, 3-1-Bii, 5-OCT.)</td><td>Ph(2-F, 3- c -Pr, 5-C2F5)</td><td>Ph(2-F, 3-C2F5, 5-Me)</td>

<td>Ph(2-F, 3-1-Bu, 5-SO2Me)</td><td>Ph(2-F, 3- c -Pr, 5-CF2CF2H)</td><td>Ph(2-F, 3-C2F5, 5-Et)</td>

<td>Ph(2-F, 3-1-Bu, 5-TMS)</td><td>Ph(2-F, 3- c -Pr, 5-CF2H)</td><td>Ph(2-F, 3-C2F5, 5-n-Pr)</td>

<td>Ph(2-F, 3-1-Bu, 5-CN)</td><td>Ph(2-F, 3- c -Pr, 5-OMe)</td><td>Ph(2-F, 3-C2F5, 5-1-Bu)</td>

<td>Ph(2-F, 3- i -Pr, 5-Cl)</td><td>Ph(2-F, 3- c -Pr, 5-OCF3)</td><td>Ph(2-F, 3-C2F5, 5- i -Pr)</td>

<td>Ph(2-F, 3- i -Pr, 5-F)</td><td>Ph(2-F, 3- c -Pr, 5-OCHF2)</td><td>Ph(2-F, 3-C2F5, 5- c -Pr)</td>

<td>Ph(2-F, 3- i -Pr, 5-Br)</td><td>Ph(2-F, 3- c -Pr, 5-OCF2CF2H)</td><td>Ph(2-F, 3-C2FsCF3, 5-CF3)</td>

<td>Ph(2-F, 3- i -Pr, 5-I)</td><td>Ph(2-F, 3- c -Pr, 5-OC2F5)</td><td>Ph(2-F, 3, 5-di-C2F5)</td>

<td>Ph(2-F, 3- i -Pr, 5-Me)</td><td>Ph(2-F, 3- c -Pr, 5-SO2Me)</td><td>Ph(2-F, 3-C2F5, 5-CF2CF2H)</td>

<td>Ph(2-F, 3- i -Pr, 5-Et)</td><td>Ph(2-F, 3- c -Pr, 5-TMS)</td><td>Ph(2-F, 3-C2F5, 5-CF2H)</td>

<td>Ph(2-F, 3- i -Pr, 5-n-Pr)</td><td>Ph(2-F, 3- c -Pr, 5-CN)</td><td>Ph(2-F, 3-C2F5, 5-OMe)</td>

<td>Ph(2-F, 3- i -Pr, 5-1-Bu)</td><td>Ph(2-F, 3-CF3, 5-Cl)</td><td>Ph(2-F, 3-C2F5, 5-OCF3)</td>

<td>Ph(2-F, 3, 5-di-i -Pr)</td><td>Ph(2-F, 3-CF3, 5-F)</td><td>Ph(2-F, 3-C2F5, 5-OCHF2)</td>

<td>Ph(2-F, 3- i -Pr, 5- c -Pr)</td><td>Ph(2-F, 3-CF3, 5-Br)</td><td>Ph(2-F, 3-C2F5, 5-OCF2CF2H)</td>

<td>Ph(2-F, 3- i -Pr, 5-CF3)</td><td>Ph(2-F, 3-CF3, 5-I)</td><td>Ph(2-F, 3-C2F5, 5-OC2F5)</td>

MD 4889 B1 2024.03.31

Q

Ph(2-F, 3-C2F5, 5-SO2Me) Ph(2-F, 3-C2F5, 5-TMS) Ph(2-F, 3-C2F5, 5-CN) Ph(2-F, 3- CF2CF2H, 5-Cl) Ph(2-F, 3-CF2CF2H, 5-F) Ph(2-F, 3-CF2CF2H, 5-Br) Ph(2-F, 3-CF2CF2H, 5-I) Ph(2-F, 3-CF2CF2H, 5-Me) Ph(2-F, 3-CF2CF2H, 5-Et) Ph(2-F, 3-CF2CF2H, 5-n-Pr) Ph(2-F, 3- CF2CF2H, 5-1-Bu) Ph(2-F, 3-CF2CF2H, 5- i -Pr) Ph(2-F, 3-CF2CF2H, 5- c -Pr) Ph(2-F, 3-CF2CF2H, 5-CF3) Ph(2-F, 3-CF2CF2H, 5-C2F5) Ph(2-F, 3, 5-di-CF2CF2H) Ph(2-F, 3-CF2CF2H, 5-CF2H) Ph(2- F, 3-CF2CF2H, 5-OMe) Ph(2-F, 3-CF2CF2H, 5-OCF3) Ph(2-F, 3-CF2CF2H, 5-OCHF2) Ph(2-F, 3-CF2CF2H, 5-OCF2CF2H) Ph(2-F, 3-CF2CF2H, 5-OC2F5) Ph(2-F, 3-CF2CF2H, 5-SO2Me) Ph(2-F, 3- CF2CF2H, 5-TMS) Ph(2-F, 3-CF2CF2H, 5-CN) Ph(2-F, 3-CF2H, 5-Cl) Ph(2-F, 3-CF2H, 5-F) Ph(2-F, 3-CF2H, 5-Br) Ph(2-F, 3-CF2H, 5-I)

Ph(2-F, 3-CF2H, 5-Me) Ph(2-F, 3-CF2H, 5-Et) Ph(2-F, 3-CF2H, 5-n-Pr) Ph(2-F, 3-CF2H, 5-1-Bu) Ph(2-F, 3-CF2H, 5- i -Pr) Ph(2-F, 3-CF2H, 5- c -Pr) Ph(2-F, 3- CF2H, 5-CF3) Ph(2-F, 3-CF2H, 5-C2F5)

Q

Ph(2-F, 3-CF2H, 5-CF2CF2H) Ph(2-F, 3, 5-di-CF2H) Ph(2-F, 3-CF2H, 5-OMe) Ph(2-F, 3- CF2H, 5-OCF3) Ph(2-F, 3-CF2H, 5-OCHF2) Ph(2-F, 3-CF2H, 5-OCF2CF2H) Ph(2-F, 3-CF2H, 5-OC2F5) Ph(2-F, 3-CF2H, 5-SO2Me) Ph(2-F, 3-CF2H, 5-TMS) Ph(2-F, 3-CF2H, 5-CN) Ph(2-F, 3-OMe, 5-Cl) Ph(2-F, 3-OMe, 5-F) Ph(2-F, 3-OMe, 5-Br) Ph(2-F, 3-OMe, 5-I) Ph(2- F, 3-OMe, 5-Me) Ph(2-F, 3-OMe, 5-Et) Ph(2-F, 3-OMe, 5-n-Pr) Ph(2-F, 3-OMe, 5-1-Bu) Ph(2-F, 3-OMe, 5- i -Pr) Ph(2-F, 3-OMe, 5- c -Pr) Ph(2-F, 3-OMe, 5- CF3) Ph(2-F, 3-OMe, 5-C2F5) Ph(2-F, 3-OMe, 5-CF2CF2H) Ph(2-F, 3-OMe, 5-CF2H) Ph(2-F, 3, 5-di-OMe) Ph(2-F, 3-OMe, 5-OCF3) Ph(2-F, 3- OMe, 5-OCHF2) Ph(2-F, 3-OMe, 5-OCF2CF2H) Ph(2-F, 3-OMe, 5-OC2F5) Ph(2-F, 3-OMe, 5-SO2Me) Ph(2-F, 3-OMe, 5-TMS) Ph(2-F, 3-OMe, 5-CN) Ph(2-F, 3-OCF3, 5-Cl) Ph(2-F, 3-OCF3, 5-F) Ph(2-F, 3-OCF3, 5-Br) Ph(2-F, 3-OCF3, 5-I) Ph(2-F, 3-OCF3, 5-Me)

Q

Ph(2-F, 3-OCF3, 5-Et) Ph(2-F, 3-OCF3, 5-n-Pr) Ph(2-F, 3-OCF3, 5-1-Bu) Ph(2- F, 3-OCF3, 5- i -Pr) Ph(2-F, 3-OCF3, 5- c -Pr) Ph(2-F, 3-OCF3, 5-CF3) Ph(2-F, 3- OCF3, 5-C2F5) Ph(2-F, 3-OCF3, 5-CF2CF2H) Ph(2-F, 3-OCF3, 5-CF2H) Ph(2-F, 3-OCF3, 5-OMe) Ph(2-F, 3, 5-di-OCF3) Ph(2-F, 3-OCF3, 5-OCHF2) Ph(2-F, 3-OCF3, 5-OCF2CF2H) Ph(2-F, 3-OCF3, 5-OC2F5) Ph(2-F, 3-OCF3, 5-SO2Me) Ph(2-F, 3-OCF3, 5-TMS) Ph(2-F, 3-OCF3, 5-CN) Ph(2- F, 3-OCHF2, 5-Cl) Ph(2-F, 3-OCHF2, 5-F) Ph(2-F, 3-OCHF2, 5-Br) Ph(2-F, 3-OCHF2, 5- I) Ph(2-F, 3-OCHF2, 5-Me) Ph(2-F, 3-OCHF2, 5-Et) Ph(2-F, 3-OCHF2, 5-n-Pr) Ph(2-F, 3-OCHF2, 5-1-Bu) Ph(2- F, 3-OCHF2, 5- i -Pr) Ph(2-F, 3-OCHF2, 5- c -Pr) Ph(2-F, 3-OCHF2CF3, 5-CF3) Ph(2-F, 3- OC2F5, 5-C2F5) Ph(2-F, 3-OCHF2, 5-CF2CF2H) Ph(2-F, 3-OCHF2, 5-CF2H) Ph(2-F, 3-OCHF2, 5-OMe) Ph(2-F, 3-OCHF2, 5-OCF3) Ph(2-F, 3, 5-di-OCHF2) Ph(2-F, 3-OCHF2, 5-OCF2CF2H) Ph(2-F, 3-OCHF2, 5-OC2F5) Ph(2-F, 3-OCHF2, 5-SO2Me)

MD 4889 B1 2024.03.31

Q

Ph(2-F, 3-OCHF2, 5-TMS) Ph(2-F, 3-OCHF2, 5-CN) Ph(2-F, 3-OCF2CF2H, 5-Cl) Ph(2-F, 3- OCF2CF2H, 5-F) Ph(2-F, 3-OCF2CF2H, 5-Br) Ph(2-F, 3-OCF2CF2H, 5-I) Ph(2-F, 3-OCF2CF2H, 5-Me) Ph(2-F, 3-OCF2CF2H, 5-Et) Ph(2-F, 3-OCF2CF2H, 5-n-Pr) Ph(2-F, 3-OCF2CF2H, 5-1-Bu) Ph(2-F, 3-OCF2CF2H, 5- i -Pr) Ph(2-F, 3-OCF2CF2H, 5- c -Pr) Ph(2-F, 3-OCF2CF2H, 5-CF3) Ph(2-F, 3-OCF2CF2H, 5-C2F5) Ph(2-F, 3-OCF2CF2H, 5-CF2CF2H) Ph(2-F, 3-OCF2CF2H, 5-CF2H) Ph(2-F, 3-OCF2CF2H, 5-OMe) Ph(2- F, 3-OCF2CF2H, 5-OCF3) Ph(2-F, 3-OCF2CF2H, 5-OCHF2) Ph(2-F, 3, 5-di-OCF2CF2H) Ph(2-F, 3-OCF2CF2H, 5-OC2F5) Ph(2-F, 3-OCF2CF2H, 5-SO2Me) Ph(2-F, 3- OCF2CF2H, 5-TMS) Ph(2-F, 3-OCF2CF2H, 5-CN) Ph(2-F, 3-OC2F5, 5-Cl) Ph(2-F, 3-OC2F5, 5-F) Ph(2-F, 3-OC2F5, 5-Br) Ph(2-F, 3-OC2F5, 5-I) Ph(2-F, 3-OC2F5, 5-Me) Ph(2-F, 3-OC2F5, 5-Et) Ph(2-F, 3-OC2F5, 5-n-Pr) Ph(2-F, 3-OC2F5, 5-1-Bu) Ph(2-F, 3-OC2F5, 5-i - Pr) Ph(2-F, 3-OC2F5, 5-c -Pr) Ph(2-F, 3-OC2FsCF3, 5-CF3) Ph(2-F, 3-OC2F5, 5-CF2CF2H) Ph(2- F, 3-OC2F5, 5-CF2H)

Q

Ph(2-F, 3-OC2F5, 5-OMe) Ph(2-F, 3-OC2F5, 5-OCF3) Ph(2-F, 3-OC2F5, 5-OCHF2) Ph(2-F, 3- OC2F5, 5-OCF2CF2H) Ph(2-F, 3, 5-di-OC2F5) Ph(2-F, 3-OC2F5, 5-SO2Me) Ph(2-F, 3-OC2F5, 5-TMS) Ph(2-F, 3-OC2F5, 5-CN) Ph(2-F, 3-SO2Me, 5-Cl) Ph(2-F, 3-SO2Me, 5-F) Ph(2-F, 3-SO2Me, 5-Br) Ph(2-F, 3-SO2Me, 5-I) Ph(2-F, 3-SO2Me, 5-Me) Ph(2-F, 3-SO2Me, 5-Et) Ph(2- F, 3-SO2Me, 5-n-Pr) Ph(2-F, 3-SO2Me, 5-1-Bu) Ph(2-F, 3-SO2Me, 5- i -Pr) Ph(2-F, 3-SO2Me, 5- c -Pr) Ph(2-F, 3-SO2MeCF3, 5-CF3) Ph(2-F, 3-SO2Me, 5-C2F5) Ph(2-F, 3-SO2Me, 5- CF2CF2H) Ph(2-F, 3-SO2Me, 5-CF2H) Ph(2-F, 3-SO2Me, 5-OMe) Ph(2-F, 3-SO2Me, 5-OCF3) Ph(2-F, 3- SO2Me, 5-OCHF2) Ph(2-F, 3-SO2Me, 5-OCF2CF2H) Ph(2-F, 3-SO2Me, 5-OC2F5) Ph(2-F, 3, 5-di-SO2Me) Ph(2-F, 3-SO2Me, 5-TMS) Ph(2-F, 3-SO2Me, 5-CN) Ph(2-F, 3-TMS, 5-Cl) Ph(2-F, 3-TMS, 5-F) Ph(2-F, 3-TMS, 5-Br) Ph(2-F, 3-TMS, 5-I) Ph(2-F, 3-TMS, 5-Me) Ph(2- F, 3-TMS, 5-Et) Ph(2-F, 3-TMS, 5-n-Pr)

Q

Ph(2-F, 3-TMS, 5-1-Bu) Ph(2-F, 3-TMS, 5- i -Pr) Ph(2-F, 3-TMS, 5- c -Pr) Ph(2-F, 3-TMS, 5-CF3) Ph(2-F, 3-TMS, 5-C2F5) Ph(2-F, 3-TMS, 5-CF2CF2H) Ph(2-F, 3-TMS, 5-CF2H) Ph(2-F, 3-TMS, 5-OMe) Ph(2-F, 3-TMS, 5-OCF3) Ph(2-F, 3-TMS, 5-OCHF2) Ph(2- F, 3-TMS, 5-OCF2CF2H) Ph(2-F, 3-TMS, 5-OC2F5) Ph(2-F, 3-TMS, 5-SO2Me) Ph(2-F, 3, 5-di- TMS) Ph(2-F, 3-TMS, 5-CN) Ph(2-F, 3-CN, 5-Cl) Ph(2-F, 3-CN, 5-F) Ph(2-F, 3-CN, 5-Br) Ph(2-F, 3-CN, 5-I) Ph(2-F, 3-CN, 5-Me) Ph(2-F, 3-CN, 5-Et) Ph(2-F, 3-CN, 5-n-Pr) Ph(2-F, 3-CN, 5-1-Bu) Ph(2-F, 3-CN, 5- i -Pr) Ph(2-F, 3-CN, 5- c -Pr) Ph(2-F, 3-CN, 5-CF3) Ph(2-F, 3-CN, 5-C2F5) Ph(2-F, 3-CN, 5-CF2CF2H) Ph(2-F, 3-CN, 5-CF2H) Ph(2-F, 3-CN, 5-OMe) Ph(2-F, 3-CN, 5-OCF3) Ph(2-F, 3-CN, 5-OCHF2) Ph(2-F, 3-CN, 5-OCF2CF2H) Ph(2-F, 3-CN, 5-OC2F5) Ph(2-F, 3- CN, 5-SO2Me) Ph(2-F, 3-CN, 5-TMS) Ph(2-F, 3, 5-di-CN)

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 4, 5-di-Cl)</td><td>Ph(2-F, 4-F, 5-OCF3)</td><td>Ph(2-F, 4-I, 5- i -Pr)</td>

<td>Ph(2-F, 4-Cl, 5-F)</td><td>Ph(2-F, 4-F, 5-OCHF2)</td><td>Ph(2-F, 4-I, 5-c -Pr)</td>

<td>Ph(2-F, 4-Cl, 5-Br)</td><td>Ph(2-F, 4-F, 5-OCF2CF2H)</td><td>Ph(2-F, 4-I, 5-CF3)</td>

<td>Ph(2-F, 4-Cl, 5-I)</td><td>Ph(2-F, 4-F, 5-OC2F5)</td><td>Ph(2-F, 4-I, 5-C2F5)</td>

<td>Ph(2-F, 4-Cl, 5-Me)</td><td>Ph(2-F, 4-F, 5-SO2Me)</td><td>Ph(2-F, 4-I, 5-CF2CF2H)</td>

<td>Ph(2-F, 4-Cl, 5-Et)</td><td>Ph(2-F, 4-F, 5-TMS)</td><td>Ph(2-F, 4-I, 5-CF2H)</td>

<td>Ph(2-F, 4-Cl, 5-n-Pr)</td><td>Ph(2-F, 4-F, 5-CN)</td><td>Ph(2-F, 4-I, 5-OMe)</td>

<td>Ph(2-F, 4-Cl, 5-1-Bu)</td><td>Ph(2-F, 4-Br, 5-Cl)</td><td>Ph(2-F, 4-I, 5-OCF3)</td>

<td>Ph(2-F, 4-Cl, 5- i -Pr)</td><td>Ph(2-F, 4-Br, 5-F)</td><td>Ph(2-F, 4-I, 5-OCHF2)</td>

<td>Ph(2-F, 4-Cl, 5- c -Pr)</td><td>Ph(2-F, 4, 5-di-Br)</td><td>Ph(2-F, 4-I, 5-OCF2CF2H)</td>

<td>Ph(2-F, 4-Cl, 5-CF3)</td><td>Ph(2-F, 4-Br, 5-I)</td><td>Ph(2-F, 4-I, 5-OC2F5)</td>

<td>Ph(2-F, 4-Cl, 5-C2F5)</td><td>Ph(2-F, 4-Br, 5-Me)</td><td>Ph(2-F, 4-I, 5-SO2Me)</td>

<td>Ph(2-F, 4-Cl, 5-CF2CF2H)</td><td>Ph(2-F, 4-Br, 5-Et)</td><td>Ph(2-F, 4-I, 5-TMS)</td>

<td>Ph(2-F, 4-Cl, 5-CF2H)</td><td>Ph(2-F, 4-Br, 5-n-Pr)</td><td>Ph(2-F, 4-I, 5-CN)</td>

<td>Ph(2-F, 4-Cl, 5-OMe)</td><td>Ph(2-F, 4-Br, 5-1-Bu)</td><td>Ph(2-F, 4-Me, 5-Cl)</td>

<td>Ph(2-F, 4-Cl, 5-OCF3)</td><td>Ph(2-F, 4-Br, 5- i -Pr)</td><td>Ph(2-F, 4-Me, 5-F)</td>

<td>Ph(2-F, 4-Cl, 5-OCHF2)</td><td>Ph(2-F, 4-Br, 5- c -Pr)</td><td>Ph(2-F, 4-Me, 5-Br)</td>

<td>Ph(2-F, 4-Cl, 5-OCF2CF2H)</td><td>Ph(2-F, 4-Br, 5-CF3)</td><td>Ph(2-F, 4-Me, 5-I)</td>

<td>Ph(2-F, 4-Cl, 5-OC2F5)</td><td>Ph(2-F, 4-Br, 5-C2F5)</td><td>Ph(2-F, 4, 5-di-Me)</td>

<td>Ph(2-F, 4-Cl, 5-SO2Me)</td><td>Ph(2-F, 4-Br, 5-CF2CF2H)</td><td>Ph(2-F, 4-Me, 5-Et)</td>

<td>Ph(2-F, 4-Cl, 5-TMS)</td><td>Ph(2-F, 4-Br, 5-CF2H)</td><td>Ph(2-F, 4-Me, 5-n-Pr)</td>

<td>Ph(2-F, 4-Cl, 5-CN)</td><td>Ph(2-F, 4-Br, 5-OMe)</td><td>Ph(2-F, 4-Me, 5-1-Bu)</td>

<td>Ph(2-F, 4-F, 5-Cl)</td><td>Ph(2-F, 4-Br, 5-OCF3)</td><td>Ph(2-F, 4-Me, 5-i -Pr)</td>

<td>Ph(2, 4, 5-tri-F)</td><td>Ph(2-F, 4-Br, 5-OCHF2)</td><td>Ph(2-F, 4-Me, 5-c -Pr)</td>

<td>Ph(2-F, 4-F, 5-Br)</td><td>Ph(2-F, 4-Br, 5-OCF2CF2H)</td><td>Ph(2-F, 4-Me, 5-CF3)</td>

<td>Ph(2-F, 4-F, 5-I)</td><td>Ph(2-F, 4-Br, 5-OC2F5)</td><td>Ph(2-F, 4-Me, 5-C2F5)</td>

<td>Ph(2-F, 4-F, 5-Me)</td><td>Ph(2-F, 4-Br, 5-SO2Me)</td><td>Ph(2-F, 4-Me, 5-CF2CF2H)</td>

<td>Ph(2-F, 4-F, 5-Et)</td><td>Ph(2-F, 4-Br, 5-TMS)</td><td>Ph(2-F, 4-Me, 5-CF2H)</td>

<td>Ph(2-F, 4-F, 5-n-Pr)</td><td>Ph(2-F, 4-Br, 5-CN)</td><td>Ph(2-F, 4-Me, 5-OMe)</td>

<td>Ph(2-F, 4-F, 5-1-Bu)</td><td>Ph(2-F, 4-I, 5-Cl)</td><td>Ph(2-F, 4-Me, 5-OCF3)</td>

<td>Ph(2-F, 4-F, 5- i -Pr)</td><td>Ph(2-F, 4-I, 5-F)</td><td>Ph(2-F, 4-Me, 5-OCHF2)</td>

<td>Ph(2-F, 4-F, 5- c -Pr)</td><td>Ph(2-F, 4-I, 5-Br)</td><td>Ph(2-F, 4-Me, 5-OCF2CF2H)</td>

<td>Ph(2-F, 4-F, 5-CF3)</td><td>Ph(2-F, 4, 5-di-I)</td><td>Ph(2-F, 4-Me, 5-OC2F5)</td>

<td>Ph(2-F, 4-F, 5-C2F5)</td><td>Ph(2-F, 4-I, 5-Me)</td><td>Ph(2-F, 4-Me, 5-SO2Me)</td>

<td>Ph(2-F, 4-F, 5-CF2CF2H)</td><td>Ph(2-F, 4-I, 5-Et)</td><td>Ph(2-F, 4-Me, 5-TMS)</td>

<td>Ph(2-F, 4-F, 5-CF2H)</td><td>Ph(2-F, 4-I, 5-n-Pr)</td><td>Ph(2-F, 4-Me, 5-CN)</td>

<td>Ph(2-F, 4-F, 5-OMe)</td><td>Ph(2-F, 4-I, 5-1-Bu)</td><td>Ph(2-F, 4-Et, 5-Cl)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 4-Et, 5-F)</td><td>Ph(2-F, 4-n-Pr, 5-OCHF2)</td><td>Ph(2-F, 4- i -Pr, 5- c -Pr)</td>

<td>Ph(2-F, 4-Et, 5-Br)</td><td>Ph(2-F, 4-n-Pr, 5-OCF2CF2H)</td><td>Ph(2-F, 4- i -Pr, 5-CF3)</td>

<td>Ph(2-F, 4-Et, 5-I)</td><td>Ph(2-F, 4-n-Pr, 5-OC2F5)</td><td>Ph(2-F, 4- i -Pr, 5-C2F5)</td>

<td>Ph(2-F, 4-Et, 5-Me)</td><td>Ph(2-F, 4-n-Pr, 5-SO2Me)</td><td>Ph(2-F, 4- i -Pr, 5-CF2CF2H)</td>

<td>Ph(2-F, 4, 5-di-Et)</td><td>Ph(2-F, 4-n-Pr, 5-TMS)</td><td>Ph(2-F, 4- i -Pr, 5-CF2H)</td>

<td>Ph(2-F, 4-Et, 5-n-Pr)</td><td>Ph(2-F, 4-n-Pr, 5-CN)</td><td>Ph(2-F, 4- i -Pr, 5-OMe)</td>

<td>Ph(2-F, 4-Et, 5-1-Bu)</td><td>Ph(2-F, 4-1-Bu, 5-Cl)</td><td>Ph(2-F, 4- i -Pr, 5-OCF3)</td>

<td>Ph(2-F, 4-Et, 5- i -Pr)</td><td>Ph(2-F, 4-1-Bu, 5-F)</td><td>Ph(2-F, 4- i -Pr, 5-OCHF2)</td>

<td>Ph(2-F, 4-Et, 5- c -Pr)</td><td>Ph(2-F, 4-1-Bu, 5-Br)</td><td>Ph(2-F, 4- i -Pr, 5-OCF2CF2H)</td>

<td>Ph(2-F, 4-Et, 5-CF3)</td><td>Ph(2-F, 4-1-Bu, 5-I)</td><td>Ph(2-F, 4- i -Pr, 5-OC2F5)</td>

<td>Ph(2-F, 4-Et, 5-C2F5)</td><td>Ph(2-F, 4-1-Bu, 5-Me)</td><td>Ph(2-F, 4- i -Pr, 5-SO2Me)</td>

<td>Ph(2-F, 4-Et, 5-CF2CF2H)</td><td>Ph(2-F, 4-1-Bu, 5-Et)</td><td>Ph(2-F, 4- i -Pr, 5-TMS)</td>

<td>Ph(2-F, 4-Et, 5-CF2H)</td><td>Ph(2-F, 4-1-Bu, 5-n-Pr)</td><td>Ph(2-F, 4- i -Pr, 5-CN)</td>

<td>Ph(2-F, 4-Et, 5-OMe)</td><td>Ph(2-F, 4, 5-di-1-Bu)</td><td>Ph(2-F, 4- c -Pr, 5-Cl)</td>

<td>Ph(2-F, 4-Et, 5-OCF3)</td><td>Ph(2-F, 4-1-Bu, 5- i -Pr)</td><td>Ph(2-F, 4- c -Pr, 5-F)</td>

<td>Ph(2-F, 4-Et, 5-OCHF2)</td><td>Ph(2-F, 4-1-Bu, 5- c -Pr)</td><td>Ph(2-F, 4- c -Pr, 5-Br)</td>

<td>Ph(2-F, 4-Et, 5-OCF2CF2H)</td><td>Ph(2-F, 4-1-Bu, 5-CF3)</td><td>Ph(2-F, 4- c -Pr, 5-I)</td>

<td>Ph(2-F, 4-Et, 5-OC2F5)</td><td>Ph(2-F, 4-1-Bu, 5-C2F5)</td><td>Ph(2-F, 4- c -Pr, 5-Me)</td>

<td>Ph(2-F, 4-Et, 5-SO2Me)</td><td>Ph(2-F, 4-1-Bu, 5-CF2CF2H)</td><td>Ph(2-F, 4- c -Pr, 5-Et)</td>

<td>Ph(2-F, 4-Et, 5-TMS)</td><td>Ph(2-F, 4-1-Bu, 5-CF2H)</td><td>Ph(2-F, 4-c-Pr, 5-n-Pr)</td>

<td>Ph(2-F, 4-Et, 5-CN)</td><td>Ph(2-F, 4-1-Bu, 5-OMe)</td><td>Ph(2-F, 4- c -Pr, 5-1-Bu)</td>

<td>Ph(2-F, 4-n-Pr, 5-Cl)</td><td>Ph(2-F, 4-1-Bu, 5-OCF3)</td><td>Ph(2-F, 4- c -Pr, 5- i -Pr)</td>

<td>Ph(2-F, 4-n-Pr, 5-F)</td><td>Ph(2-F, 4-1-Bu, 5-OCHF2)</td><td>Ph(2-F, 4, 5-di-c-Pr)</td>

<td>Ph(2-F, 4-n-Pr, 5-Br)</td><td>Ph(2-F, 4-1-Bu, 5-OCF2CF2H)</td><td>Ph(2-F, 4- c -Pr, 5-CF3)</td>

<td>Ph(2-F, 4-n-Pr, 5-I)</td><td>Ph(2-F, 4-1-Bu, 5-OC2F5)</td><td>Ph(2-F, 4- c -Pr, 5-C2F5)</td>

<td>Ph(2-F, 4-n-Pr, 5-Me)</td><td>Ph(2-F, 4-1-Bu, 5-SO2Me)</td><td>Ph(2-F, 4- c -Pr, 5-CF2CF2H)</td>

<td>Ph(2-F, 4-n-Pr, 5-Et)</td><td>Ph(2-F, 4-1-Bu, 5-TMS)</td><td>Ph(2-F, 4- c -Pr, 5-CF2H)</td>

<td>Ph(2-F, 4, 5-di-n-Pr)</td><td>Ph(2-F, 4-1-Bu, 5-CN)</td><td>Ph(2-F, 4- c -Pr, 5-OMe)</td>

<td>Ph(2-F, 4-n-Pr, 5-1-Bu)</td><td>Ph(2-F, 4- i -Pr, 5-Cl)</td><td>Ph(2-F, 4- c -Pr, 5-OCF3)</td>

<td>Ph(2-F, 4-n -Pr, 5- i -Pr)</td><td>Ph(2-F, 4- i -Pr, 5-F)</td><td>Ph(2-F, 4- c -Pr, 5-OCHF2)</td>

<td>Ph(2-F, 4-n-Pr, 5-c-Pr)</td><td>Ph(2-F, 4- i -Pr, 5-Br)</td><td>Ph(2-F, 4- c -Pr, 5-OCF2CF2H)</td>

<td>Ph(2-F, 4-n-Pr, 5-CF3)</td><td>Ph(2-F, 4- i -Pr, 5-I)</td><td>Ph(2-F, 4- c -Pr, 5-OC2F5)</td>

<td>Ph(2-F, 4-n-Pr, 5-C2F5)</td><td>Ph(2-F, 4- i -Pr, 5-Me)</td><td>Ph(2-F, 4- c -Pr, 5-SO2Me)</td>

<td>Ph(2-F, 4-n-Pr, 5-CF2CF2H)</td><td>Ph(2-F, 4- i -Pr, 5-Et)</td><td>Ph(2-F, 4- c -Pr, 5-TMS)</td>

<td>Ph(2-F, 4-n-Pr, 5-CF2H)</td><td>Ph(2-F, 4- i -Pr, 5-n-Pr)</td><td>Ph(2-F, 4- c -Pr, 5-CN)</td>

<td>Ph(2-F, 4-n-Pr, 5-OMe)</td><td>Ph(2-F, 4- i -Pr, 5-1-Bu)</td><td>Ph(2-F, 4-CF3, 5-Cl)</td>

<td>Ph(2-F, 4-n-Pr, 5-OCF3)</td><td>Ph(2-F, 4, 5-di-i-Pr)</td><td>Ph(2-F, 4-CF3, 5-F)</td>

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 4-CF3, 5-Br)</td><td>Ph(2-F, 4-CF2CF3, 5-OCF2CF2H)</td><td>Ph(2-F, 4-CF2H, 5-CF3)</td>

<td>Ph(2-F, 4-CF3, 5-I)</td><td>PI1(2-P, 4-CP;CP;, 5-O)C;P·.)</td><td>Ph(2-F, 4-CF2H, 5-C2F5)</td>

<td>Ph(2-F, 4-CF3, 5-Me)</td><td>Ph(2-F, 4-CF2CF3, 5-SO2Me)</td><td>Ph(2-F, 4-CF2H, 5-CF2CF2H)</td>

<td>Ph(2-F, 4-CF3, 5-Et)</td><td>Ph(2-F, 4-CF2CF3, 5-TMS)</td><td>Ph(2-F, 4, 5-di-CF2H)</td>

<td>Ph(2-F, 4-CF3, 5-n-Pr)</td><td>Ph(2-F, 4-CF2CF3, 5-CN)</td><td>Ph(2-F, 4-CF2H, 5-OMe)</td>

<td>Ph(2-F, 4-CF3, 5-1-Bu)</td><td>Ph(2-F, 4-CF2CF2H, 5-Cl)</td><td>Ph(2-F, 4-CF2H, 5-OCF3)</td>

<td>Ph(2-F, 4-CF3, 5- i -Pr)</td><td>Ph(2-F, 4-CF2CF2H, 5-F)</td><td>Ph(2-F, 4-CF2H, 5-OCHF2)</td>

<td>Ph(2-F, 4-CF3, 5-c -Pr)</td><td>Ph(2-F, 4-CF2CF2H, 5-Br)</td><td>Ph(2-F, 4-CF2H, 5-OCF2CF2H)</td>

<td>Ph(2-F, 4, 5-di-CF3)</td><td>Ph(2-F, 4-CF2CF2H, 5-I)</td><td>Ph(2-F, 4-CF2H, 5-OC2F5)</td>

<td>PI1(2-1^;, 4-C1^;;, 5-CT.)</td><td>Ph(2-F, 4-CF2CF2H, 5-Me)</td><td>Ph(2-F, 4-CF2H, 5-SO2Me)</td>

<td>Ph(2-F, 4-CF3, 5-CF2CF2H)</td><td>Ph(2-F, 4-CF2CF2H, 5-Et)</td><td>Ph(2-F, 4-CF2H, 5-TMS)</td>

<td>Ph(2-F, 4-CF3, 5-CF2H)</td><td>Ph(2-F, 4-CF2CF2H, 5-n-Pr)</td><td>Ph(2-F, 4-CF2H, 5-CN)</td>

<td>Ph(2-F, 4-CF3, 5-OMe)</td><td>Ph(2-F, 4-CF2CF2H, 5-1-Bu)</td><td>Ph(2-F, 4-OMe, 5-Cl)</td>

<td>Ph(2-F, 4-CF3, 5-OCF3)</td><td>Ph(2-F, 4-CF2CF2H, 5- i -Pr)</td><td>Ph(2-F, 4-OMe, 5-F)</td>

<td>Ph(2-F, 4-CF3, 5-OCHF2)</td><td>Ph(2-F, 4-CF2CF2H, 5- c -Pr)</td><td>Ph(2-F, 4-OMe, 5-Br)</td>

<td>Ph(2-F, 4-CF3, 5-OCF2CF2H)</td><td>Ph(2-F, 4-CF2CF2CF3H, 5-CF3)</td><td>Ph(2-F, 4-OMe, 5-I)</td>

<td>PI1(2-1^;, 4-C1^;;, 5-O)CT.)</td><td>Ph(2-F, 4-CF2CF2H, 5-C2F5)</td><td>Ph(2-F, 4-OMe, 5-Me)</td>

<td>Ph(2-F, 4-CF3, 5-SO2Me)</td><td>Ph(2-F, 4, 5-di-CF2CF2H)</td><td>Ph(2-F, 4-OMe, 5-Et)</td>

<td>Ph(2-F, 4-CF3, 5-TMS)</td><td>Ph(2-F, 4-CF2CF2H, 5-CF2H)</td><td>Ph(2-F, 4-OMe, 5-n-Pr)</td>

<td>Ph(2-F, 4-CF3, 5-CN)</td><td>Ph(2-F, 4-CF2CF2H, 5-OMe)</td><td>Ph(2-F, 4-OMe, 5-1-Bu)</td>

<td>Ph(2-F, 4-CF2CF3, 5-Cl)</td><td>Ph(2-F, 4-CF2CF2H, 5-OCF3)</td><td>Ph(2-F, 4-OMe, 5- i -Pr)</td>

<td>Ph(2-F, 4-CF2CF3, 5-F)</td><td>Ph(2-F, 4-CF2CF2H, 5-OCHF2)</td><td>Ph(2-F, 4-OMe, 5- c -Pr)</td>

<td>Ph(2-F, 4-CF2CF3, 5-Br)</td><td>Ph(2-F, 4-CF2CF2H, 5-OCF2CF2H)</td><td>Ph(2-F, 4-OMe, 5-CF3)</td>

<td>Ph(2-F, 4-CF2CF3, 5-I)</td><td>Ph(2-F, 4-CF2CF2H, 5-OC2F5)</td><td>Ph(2-F, 4-OMe, 5-C2F5)</td>

<td>Ph(2-F, 4-CF2CF3, 5-Me)</td><td>Ph(2-F, 4-CF2CF2H, 5-SO2Me)</td><td>Ph(2-F, 4-OMe, 5-CF2CF2H)</td>

<td>Ph(2-F, 4-CF2CF3, 5-Et)</td><td>Ph(2-F, 4-CF2CF2H, 5-TMS)</td><td>Ph(2-F, 4-OMe, 5-CF2H)</td>

<td>Ph(2-F, 4-CF2CF3, 5-n-Pr)</td><td>Ph(2-F, 4-CF2CF2H, 5-CN)</td><td>Ph(2-F, 4, 5-di-OMe)</td>

<td>Ph(2-F, 4-CF2CF3, 5-1-Bu)</td><td>Ph(2-F, 4-CF2H, 5-Cl)</td><td>Ph(2-F, 4-OMe, 5-OCF3)</td>

<td>Ph(2-F, 4-CF2CF3, 5- i -Pr)</td><td>Ph(2-F, 4-CF2H, 5-F)</td><td>Ph(2-F, 4-OMe, 5-OCHF2)</td>

<td>Ph(2-F, 4-CF2CF3, 5-c -Pr)</td><td>Ph(2-F, 4-CF2H, 5-Br)</td><td>Ph(2-F, 4-OMe, 5-OCF2CF2H)</td>

<td>PI1(2-P, 4-C;P-.CP;, 5-CP;)</td><td>Ph(2-F, 4-CF2H, 5-I)</td><td>Ph(2-F, 4-OMe, 5-OC2F5)</td>

<td>Ph(2-F, 4, 5-di-C2F5)</td><td>Ph(2-F, 4-CF2H, 5-Me)</td><td>Ph(2-F, 4-OMe, 5-SO2Me)</td>

<td>Ph(2-F, 4-CF2CF3, 5-CF2CF2H)</td><td>Ph(2-F, 4-CF2H, 5-Et)</td><td>Ph(2-F, 4-OMe, 5-TMS)</td>

<td>Ph(2-F, 4-CF2CF3, 5-CF2H)</td><td>Ph(2-F, 4-CF2H, 5-n-Pr)</td><td>Ph(2-F, 4-OMe, 5-CN)</td>

<td>Ph(2-F, 4-CF2CF3, 5-OMe)</td><td>Ph(2-F, 4-CF2H, 5-1-Bu)</td><td>Ph(2-F, 4-OCF3, 5-Cl)</td>

<td>Ph(2-F, 4-CF2CF3, 5-OCF3)</td><td>Ph(2-F, 4-CF2H, 5- i -Pr)</td><td>Ph(2-F, 4-OCF3, 5-F)</td>

<td>Ph(2-F, 4-CF2CF3, 5-OCHF2)</td><td>Ph(2-F, 4-CF2H, 5- c -Pr)</td><td>Ph(2-F, 4-OCF3, 5-Br)</td>

MD 4889 B1 2024.03.31

Q

Ph(2-F, 4-OCF3, 5-I) Ph(2-F, 4-OCF3, 5-Me) Ph(2-F, 4-OCF3, 5-Et) Ph(2-F, 4- OCF3, 5-n-Pr) Ph(2-F, 4-OCF3, 5-1-Bu) Ph(2-F, 4-OCF3, 5- i -Pr) Ph(2-F, 4-OCF3, 5- c -Pr) Ph(2-F, 4-OCF3, 5-CF3) PI1(2-1^;, 4-OC1^;;, 5-CT.) Ph(2-F, 4-OCF3, 5-CF2CF2H) Ph(2-F, 4-OCF3, 5-CF2H) Ph(2-F, 4-OCF3, 5-OMe) Ph (2-F, 4, 5-di-OCF3) Ph(2-F, 4-OCF3, 5-OCHF2) Ph(2-F, 4-OCF3, 5-OCF2CF2H) PI1(2-1^;, 4-OC1^;;, 5-OCT.) Ph(2-F, 4-OCF3, 5-SO2Me) Ph(2-F, 4-OCF3, 5-TMS) Ph(2-F, 4-OCF3, 5-CN) Ph (2-F, 4-OCHF2, 5-Cl) Ph(2-F, 4-OCHF2, 5-F) Ph(2-F, 4-OCHF2, 5-Br) Ph(2-F, 4-OCHF2, 5-I) Ph(2-F, 4-OCHF2, 5-Me) Ph(2-F, 4-OCHF2, 5-Et) Ph(2-F, 4-OCHF2, 5-n-Pr) Ph (2-F, 4-OCHF2, 5-1-Bu) Ph(2-F, 4-OCHF2, 5- i -Pr) Ph(2-F, 4-OCHF2, 5- c -Pr) Ph(2 -F, 4-OCHF2CF3, 5-CF3) PI1(2-P, 4-OCP;CP;, 5-C;P·.) Ph(2-F, 4-OCHF2, 5-CF2CF2H) Ph(2- F, 4-OCHF2, 5-CF2H) Ph(2-F, 4-OCHF2, 5-OMe) Ph(2-F, 4-OCHF2, 5-OCF3) Ph(2-F, 4, 5-di- OCHF2)

Ph(2-F, 4-OCHF2, 5-OCF2CF2H)

Q

Ph(2-F, 4-OCHF2, 5-OC2F5) Ph(2-F, 4-OCHF2, 5-SO2Me) Ph(2-F, 4-OCHF2, 5-TMS) Ph(2-F, 4- OCHF2, 5-CN) Ph(2-F, 4-OCF2CF2H, 5-Cl) Ph(2-F, 4-OCF2CF2H, 5-F) Ph(2-F, 4-OCF2CF2H, 5-Br) Ph(2-F, 4-OCF2CF2H, 5-I) Ph(2-F, 4-OCF2CF2H, 5-Me) Ph(2-F, 4-OCF2CF2H, 5-Et) Ph(2-F, 4-OCF2CF2H, 5-n-Pr) Ph(2-F, 4-OCF2CF2H, 5-1-Bu) Ph(2-F, 4-OCF2CF2H, 5- i -Pr) Ph(2-F, 4-OCF2CF2H, 5- c -Pr) Ph(2-F, 4-OCF2CF2CF3H, 5-CF3) Ph(2-F, 4-OCF2CF2H, 5-C2F5) Ph(2-F, 4-OCF2CF2H, 5-CF2CF2H) Ph(2- F, 4-OCF2CF2H, 5-CF2H) Ph(2-F, 4-OCF2CF2H, 5-OMe) Ph(2-F, 4-OCF2CF2H, 5-OCF3) Ph(2-F, 4-OCF2CF2H, 5-OCHF2) Ph(2-F, 4, 5-di-OCF2CF2H) Ph(2-F, 4- OCF2CF2H, 5-OC2F5) Ph(2-F, 4-OCF2CF2H, 5-SO2Me) Ph(2-F, 4-OCF2CF2H, 5-TMS) Ph(2-F, 4-OCF2CF2H, 5-CN) Ph(2-F, 4-OCF2CF3, 5-Cl) Ph(2-F, 4-OCF2CF3, 5-F) Ph(2-F, 4-OCF2CF3, 5-Br) Ph(2-F, 4-OCF2CF3, 5-I) Ph(2-F, 4-OCF2CF3, 5-Me) Ph(2-F, 4-OCF2CF3, 5-Et)

Ph(2-F, 4-OCF2CF3, 5-n-Pr) Ph(2-F, 4-OCF2CF3, 5-1-Bu) Ph(2-F, 4-OCF2CF3, 5- i -Pr) Ph(2-F, 4-OCF2CF3, 5- c -Pr) Ph(2-F, 4-OC2FsCF3, 5-CF3)

Q

Ph(2-F, 4-OCF2CF3, 5-CF2CF2H) Ph(2-F, 4-OCF2CF3, 5-CF2H) Ph(2-F, 4-OCF2CF3, 5-OMe) Ph(2-F, 4- OCF2CF3, 5-OCF3) Ph(2-F, 4-OCF2CF3, 5-OCHF2) Ph(2-F, 4-OCF2CF3, 5-OCF2CF2H) Ph(2-F, 4, 5-di-OC2F5) Ph(2-F, 4-OCF2CF3, 5-SO2Me) Ph(2-F, 4-OCF2CF3, 5-TMS) Ph(2-F, 4-OCF2CF3, 5-CN) Ph(2-F, 4-SO2Me, 5-Cl) Ph(2-F, 4-SO2Me, 5-F) Ph(2-F, 4-SO2Me, 5-Br) Ph(2-F, 4-SO2Me, 5-I) Ph(2- F, 4-SO2Me, 5-Me) Ph(2-F, 4-SO2Me, 5-Et) Ph(2-F, 4-SO2Me, 5-n-Pr) Ph(2-F, 4-SO2Me, 5-1-Bu) Ph(2-F, 4-SO2Me, 5- i -Pr) Ph(2-F, 4-SO2Me, 5- c -Pr) Ph(2-F, 4-SO2MeCF3, 5- CF3) Ph(2-F, 4-SO2Me, 5-C2F5) Ph(2-F, 4-SO2Me, 5-CF2CF2H) Ph(2-F, 4-SO2Me, 5-CF2H) Ph(2-F, 4- SO2Me, 5-OMe) Ph(2-F, 4-SO2Me, 5-OCF3) Ph(2-F, 4-SO2Me, 5-OCHF2) Ph(2-F, 4-SO2Me, 5-OCF2CF2H) Ph(2-F, 4-SO2Me, 5-OC2F5) Ph(2-F, 4, 5-di-SO2Me) Ph(2-F, 4-SO2Me, 5-TMS) Ph(2-F, 4-SO2Me, 5-CN) Ph(2-F, 4-TMS, 5-Cl) Ph(2-F, 4-TMS, 5-F) Ph(2-F, 4-TMS, 5-Br) Ph(2- F, 4-TMS, 5-I) Ph(2-F, 4-TMS, 5-Me)

MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹</td><td>Q¹</td>

<td>Ph(2-F, 4-TMS, 5-Et)</td><td>Ph(2-F, 4-CN, 5-TMS)</td><td>Ph(3-F, 4-CF2H, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5-n-Pr)</td><td>Ph(2-F, 4, 5-di-CN)</td><td>Ph(3-F, 4-OMe, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5-1-Bu)</td><td>Ph(3, 4, 5-tri-Cl)</td><td>Ph(3-F, 4-OCF3, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5- i -Pr)</td><td>Ph(3-Cl, 4-F, 5-Cl)</td><td>Ph(3-F, 4-OCHF2, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5- c -Pr)</td><td>Ph(3-Cl, 4-Br, 5-Cl)</td><td>Ph(3-F, 4-OCF2CF2H, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5-CF3)</td><td>Ph(3-Cl, 4-I, 5-Cl)</td><td>Ph(3-F, 4-OC2F5, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5-C2F5)</td><td>Ph(3-Cl, 4-Me, 5-Cl)</td><td>Ph(3-F, 4-SO2Me, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5-CF2CF2H)</td><td>Ph(3-Cl, 4-Et, 5-Cl)</td><td>Ph(3-F, 4-TMS, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5-CF2H)</td><td>Ph(3-Cl, 4-n-Pr, 5-Cl)</td><td>Ph(3-F, 4-CN, 5-F)</td>

<td>Ph(2-F, 4-TMS, 5-OMe)</td><td>Ph(3-Cl, 4-1-Bu, 5-Cl)</td><td>Ph(3-Br, 4-Cl, 5-Br)</td>

<td>Ph(2-F, 4-TMS, 5-OCF3)</td><td>Ph(3-Cl, 4- i -Pr, 5-Cl)</td><td>Ph(3-Br, 4-F, 5-Br)</td>

<td>Ph(2-F, 4-TMS, 5-OCHF2)</td><td>Ph(3-Cl, 4- c -Pr, 5-Cl)</td><td>Ph(3, 4, 5-tri-Br)</td>

<td>Ph(2-F, 4-TMS, 5-OCF2CF2H)</td><td>Ph(3-Cl, 4-CF3, 5-Cl)</td><td>Ph(3-Br, 4-I, 5-Br)</td>

<td>PI1(2-1^;, 4-T\1S, 5-OCT.)</td><td>Ph(3-Cl, 4-C2F5, 5-Cl)</td><td>Ph(3-Br, 4-Me, 5-Br)</td>

<td>Ph(2-F, 4-TMS, 5-SO2Me)</td><td>Ph(3-Cl, 4-CF2CF2H, 5-Cl)</td><td>Ph(3-Br, 4-Et, 5-Br)</td>

<td>Ph(2-F, 4, 5-di-TMS)</td><td>Ph(3-Cl, 4-CF2H, 5-Cl)</td><td>Ph(3-Br, 4-n-Pr, 5-Br)</td>

<td>Ph(2-F, 4-TMS, 5-CN)</td><td>Ph(3-Cl, 4-OMe, 5-Cl)</td><td>Ph(3-Br, 4-1-Bu, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-Cl)</td><td>Ph(3-Cl, 4-OCF3, 5-Cl)</td><td>Ph(3-Br, 4- i -Pr, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-F)</td><td>Ph(3-Cl, 4-OCHF2, 5-Cl)</td><td>Ph(3-Br, 4- c -Pr, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-Br)</td><td>Ph(3-Cl, 4-OCF2CF2H, 5-Cl)</td><td>Ph(3-Br, 4-CF3, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-I)</td><td>Ph(3-Cl, 4-OC2F5, 5-Cl)</td><td>Ph(3-Br, 4-C2F5, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-Me)</td><td>Ph(3-Cl, 4-SO2Me, 5-Cl)</td><td>Ph(3-Br, 4-CF2CF2H, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-Et)</td><td>Ph(3-Cl, 4-TMS, 5-Cl)</td><td>Ph(3-Br, 4-CF2H, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-n-Pr)</td><td>Ph(3-Cl, 4-CN, 5-Cl)</td><td>Ph(3-Br, 4-OMe, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-1-Bu)</td><td>Ph(3-F, 4-Cl, 5-F)</td><td>Ph(3-Br, 4-OCF3, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5- i -Pr)</td><td>Ph(3, 4, 5-tri-F)</td><td>Ph(3-Br, 4-OCHF2, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5- c -Pr)</td><td>Ph(3-F, 4-Br, 5-F)</td><td>Ph(3-Br, 4-OCF2CF2H, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-CF3)</td><td>Ph(3-F, 4-I, 5-F)</td><td>Ph(3-Br, 4-OC2F5, 5-Br)</td>

<td>PI1(2-P, 4-C\, 5-C;P·.)</td><td>Ph(3-F, 4-Me, 5-F)</td><td>Ph(3-Br, 4-SO2Me, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-CF2CF2H)</td><td>Ph(3-F, 4-Et, 5-F)</td><td>Ph(3-Br, 4-TMS, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-CF2H)</td><td>Ph(3-F, 4-n-Pr, 5-F)</td><td>Ph(3-Br, 4-CN, 5-Br)</td>

<td>Ph(2-F, 4-CN, 5-OMe)</td><td>Ph(3-F, 4-1-Bu, 5-F)</td><td>Ph(3-Me, 4-Cl, 5-Me)</td>

<td>Ph(2-F, 4-CN, 5-OCF3)</td><td>Ph(3-F, 4- i -Pr, 5-F)</td><td>Ph(3-Me, 4-F, 5-Me)</td>

<td>Ph(2-F, 4-CN, 5-OCHF2)</td><td>Ph(3-F, 4- c -Pr, 5-F)</td><td>Ph(3-Me, 4-Br, 5-Me)</td>

<td>Ph(2-F, 4-CN, 5-OCF2CF2H)</td><td>Ph(3-F, 4-CF3, 5-F)</td><td>Ph(3-Me, 4-I, 5-Me)</td>

<td>PI1(2-P, 4-C\, 5-OC;P·.)</td><td>Ph(3-F, 4-C2F5, 5-F)</td><td>Ph(3, 4-tri-Me)</td>

<td>Ph(2-F, 4-CN, 5-SO2Me)</td><td>Ph(3-F, 4-CF2CF2H, 5-F)</td><td>Ph(3-Me, 4-Et, 5-Me)</td>

MD 4889 B1 2024.03.31

Q

Ph(3-Me, 4-n-Pr, 5-Me) Ph(3-Me, 4-1-Bu, 5-Me) Ph(3-Me, 4-i -Pr, 5-Me) Ph(3-Me, 4-c -Pr, 5-Me) Ph(3-Me, 4-CF3, 5-Me) Ph(3-Me, 4-C2F5, 5-Me) Ph(3-Me, 4- CF2CF2H, 5-Me) Ph(3-Me, 4-CF2H, 5-Me) Ph(3-Me, 4-OMe, 5-Me) Ph(3-Me, 4-OCF3, 5-Me) Ph(3-Me, 4-OCHF2, 5-Me) Ph(3-Me, 4-OCF2CF2H, 5-Me) Ph(3-Me, 4-OC2F5, 5-Me) Ph(3-Me, 4-SO2Me, 5-Me) Ph(3-Me, 4-TMS, 5-Me) Ph(3-Me, 4-CN, 5-Me) Ph(3-CF3, 4-Cl, 5-CF3)

Ph(3-CF3, 4-F, 5-CF3) Ph(3-CF3, 4-Br, 5-CF3) Ph(3-CF3, 4-I, 5-CF3) Ph(3-CF3, 4- Me, 5-CF3) Ph(3-CF3, 4-Et, 5-CF3) Ph(3-CF3, 4-n-Pr, 5-CF3) Ph(3-CF3, 4-1-Bu, 5- CF3) Ph(3-CF3, 4- i -Pr, 5-CF3) Ph(3-CF3, 4-c -Pr, 5-CF3) Ph(3, 4, 5-tri-CF3) Ph(3- CF3, 4-C2F5, 5-CF3) Ph(3-CF3, 4-CF2CF2H, 5-CF3) Ph(3-CF3, 4-CF2H, 5-CF3) Ph(3-CF3, 4-OMe, 5- CF3) Ph(3-CF3, 4-OCF3, 5-CF3) Ph(3-CF3, 4-OCHF2, 5-CF3) Ph(3-CF3, 4-OCF2CF2H, 5-CF3) Ph(3, 5- di-CF3, 4-OC2F5) Ph(3-CF3, 4-SO2Me, 5-CF3) Ph(3-CF3, 4-TMS, 5-CF3)

Q¹

Ph(3-CF3, 4-CN, 5-CF3) Ph(3-OCHF2, 4-Cl, 5-OCHF2) Ph(3-OCHF2, 4-F, 5-OCHF2) Ph(3-OCHF2, 4- Br, 5-OCHF2) Ph(3-OCHF2, 4-I, 5-OCHF2) Ph(3-OCHF2, 4-Me, 5-OCHF2) Ph(3-OCHF2, 4-Et, 5-OCHF2) Ph(3-OCHF2, 4-n-Pr, 5-OCHF2) Ph(3-OCHF2, 4-1-Bu, 5-OCHF2) Ph(3-OCHF2, 4- i -Pr, 5-OCHF2) Ph(3- OCHF2, 4- c -Pr, 5-OCHF2) Ph(3, 5-di-OCHF2CF3, 4-CF3,) Ph(3-OC2F5, 4-C2F5, 5-OCHF2) Ph(3, 5-di-OCHF2, 4-CF2CF2H) Ph(3-OCHF2, 4-CF2H, 5-OCHF2) Ph(3-OCHF2, 4-OMe, 5-OCHF2) Ph(3-OCHF2, 4-OCF3, 5-OCHF2) Ph(3, 4, 5-tri-OCHF2)

Ph(3, 5-di-OCHF2, 4-OCF2CF2H) Ph(3, 5-di-OCHF2, 4-OC2F5) Ph(3, 5-di-OCHF2, 4-SO2Me)

Ph(3-OCHF2, 4-TMS, 5-OCHF2) Ph(3-OCHF2, 4-CN, 5-OCHF2) Ph(2, 3, 4, 5-tetra-Cl) Ph(2-Cl, 3- Cl, 4-F, 5-Cl) Ph(2-Cl, 3-Cl, 4-Br, 5-Cl) Ph(2-Cl, 3-Cl, 4-I, 5-Cl) Ph(2- Cl, 3-Cl, 4-Me, 5-Cl) Ph(2-Cl, 3-Cl, 4-Et, 5-Cl) Ph(2-Cl, 3-Cl, 4-n-Pr, 5- Cl) Ph(2-Cl, 3-Cl, 4-1-Bu, 5-Cl) Ph(2-Cl, 3-Cl, 4- i -Pr, 5-Cl) Ph(2-Cl, 3- Cl, 4- c -Pr, 5-Cl) Ph(2-Cl, 3-Cl, 4-CF3, 5-Cl) Ph(2-Cl, 3, 5-di-Cl, 4-C2F5) Ph(2-Cl, 3-Cl, 4-CF2CF2H, 5-Cl) Ph(2-Cl, 3-Cl, 4-CF2H, 5-Cl)

Q¹

Ph(2-Cl, 3-Cl, 4-OMe, 5-Cl) Ph(2-Cl, 3-Cl, 4-OCF3, 5-Cl) Ph(2-Cl, 3-Cl, 4-OCHF2, 5-Cl) Ph(2-Cl, 3-Cl, 4-OCF2CF2H, 5-Cl) Ph(2-Cl, 3, 5-di-Cl, 4-OC2F5) Ph(2-Cl, 3-Cl, 4-SO2Me, 5-Cl) Ph(2-Cl, 3-Cl, 4-TMS, 5-Cl) Ph(2-Cl, 3-Cl, 4-CN, 5-Cl) Ph(2-Cl, 3-F, 4-Cl, 5-F) Ph(2-Cl, 3, 4, 5-tri-F) Ph(2-Cl, 3-F, 4-Br, 5-F) Ph(2- Cl, 3-F, 4-I, 5-F) Ph(2-Cl, 3-F, 4-Me, 5-F) Ph(2-Cl, 3-F, 4-Et, 5-F) Ph(2-Cl, 3-F, 4-n-Pr, 5-F) Ph(2-Cl, 3-F, 4-1-Bu, 5-F) Ph(2-Cl, 3-F, 4- i -Pr, 5-F) Ph(2-Cl, 3-F, 4- c -Pr, 5-F) Ph(2-Cl, 3-F, 4-CF3, 5-F) Ph(2-Cl, 3-F, 4-C2F5, 5-F) Ph(2-Cl, 3-F, 4-CF2CF2H, 5-F) Ph(2-Cl, 3-F, 4-CF2H, 5-F) Ph(2-Cl, 3-F, 4-OMe, 5-F) Ph(2-Cl, 3-F, 4-OCF3, 5-F) Ph(2-Cl, 3-F, 4-OCHF2, 5-F) Ph(2-Cl, 3-F, 4-OCF2CF2H, 5-F) Ph(2-Cl, 3, 5-di-F, 4-OC2F5,) Ph(2-Cl, 3-F, 4-SO2Me, 5-F) Ph(2-Cl, 3-F, 4-TMS, 5-F) Ph(2-Cl, 3-F, 4-CN, 5-F) Ph(2-Cl, 3-Br, 4-Cl, 5-Br) Ph (2-Cl, 3-Br, 4-F, 5-Br) Ph(2-Cl, 3, 4, 5-tri-Br)

Ph(2-Cl, 3-Br, 4-I, 5-Br) Ph(2-Cl, 3-Br, 4-Me, 5-Br) Ph(2-Cl, 3-Br, 4-Et, 5-Br) Ph(2-Cl, 3-Br, 4-n-Pr, 5-Br)

MD 4889 B1 2024.03.31

Q

Ph(2-Cl, 3-Br, 4-1-Bu, 5-Br) Ph(2-Cl, 3-Br, 4- i -Pr, 5-Br) Ph(2-Cl, 3-Br, 4- c -Pr, 5-Br) Ph(2-Cl, 3-Br, 4-CF3, 5-Br) Ph(2-Cl, 3, 5-di-Br, 4-C2F5) Ph(2- Cl, 3-Br, 4-CF2CF2H, 5-Br) Ph(2-Cl, 3-Br, 4-CF2H, 5-Br) Ph(2-Cl, 3-Br, 4-OMe, 5-Br) Ph(2-Cl, 3-Br, 4-OCF3, 5-Br) Ph(2-Cl, 3-Br, 4-OCHF2, 5-Br) Ph(2-Cl, 3-Br, 4-OCF2CF2H, 5-Br) Ph(2-Cl, 3, 5-di-Br, 4-OC2F5) Ph(2-Cl, 3-Br, 4-SO2Me, 5-Br) Ph(2-Cl, 3-Br, 4-TMS, 5-Br) Ph(2-Cl, 3-Br, 4-CN, 5-Br) Ph(2-Cl, 3-Me, 4-Cl, 5-Me) Ph(2-Cl, 3-Me, 4-F, 5-Me) Ph(2-Cl, 3-Me, 4-Br, 5-Me) Ph(2-Cl, 3-Me, 4-I, 5-Me) Ph(2-Cl, 3, 4-tri-Me) Ph(2-Cl, 3-Me, 4-Et, 5-Me) Ph(2-Cl, 3-Me, 4-n-Pr, 5- Me) Ph(2-Cl, 3-Me, 4-1-Bu, 5-Me) Ph(2-Cl, 3-Me, 4- i -Pr, 5-Me) Ph(2-Cl, 3- Me, 4- c -Pr, 5-Me) Ph(2-Cl, 3-Me, 4-CF3, 5-Me) Ph(2-Cl, 3, 5-di-Me, 4-C2F5)

Ph(2-Cl, 3-Me, 4-CF2CF2H, 5-Me) Ph(2-Cl, 3-Me, 4-CF2H, 5-Me) Ph(2-Cl, 3-Me, 4-OMe, 5-Me) Ph(2-Cl, 3-Me, 4-OCF3, 5-Me) Ph(2-Cl, 3-Me, 4-OCHF2, 5-Me) Ph(2-Cl, 3, 5- di-Me, 4-OCF2CF2H) Ph(2-Cl, 3-Me, 4-OC2F5, 5-Me) Ph(2-Cl, 3, 5-di-Me, 4-SO2Me) Ph(2-Cl, 3-Me, 4-TMS, 5-Me) Ph(2-Cl, 3-Me, 4-CN, 5-Me)

Q

Ph(2-Cl, 3-CF3, 4-Cl, 5-CF3) Ph(2-Cl, 3-CF3, 4-F, 5-CF3) Ph(2-Cl, 3-CF3, 4-Br, 5-CF3) Ph(2-Cl, 3-CF3, 4-I, 5-CF3) Ph(2-Cl, 3-CF3, 4-Me, 5-CF3) Ph(2-Cl, 3-CF3, 4-Et, 5-CF3) Ph(2-Cl, 3-CF3, 4-n-Pr, 5-CF3) Ph(2-Cl, 3-CF3, 4-1-Bu, 5-CF3) Ph(2-Cl, 3-CF3, 4- i -Pr, 5-CF3) Ph(2-Cl, 3-CF3, 4- c -Pr, 5-CF3) Ph(2-Cl, 3, 4, 5- tri-CF3) Ph(2-Cl, 3, 5-di-CF3, 4-C2F5) Ph(2-Cl, 3, 5-di-CF3, 4-CF2CF2H) Ph(2-Cl, 3-CF3, 4-CF2H, 5-CF3) Ph(2-Cl, 3-CF3, 4-OMe, 5-CF3) Ph(2-Cl, 3-CF3, 4-OCF3, 5-CF3) Ph(2-Cl, 3-CF3, 4-OCHF2, 5-CF3) Ph(2-Cl, 3, 5-di-CF3, 4-OCF2CF2H-) Ph(2-Cl, 3, 5-di-CF3, 4-OC2F5) Ph(2-Cl, 3, 5-di-CF3, 4-SO2Me) Ph(2-Cl, 3, 5-di-CF3, 4-TMS) Ph(2-Cl, 3-CF3, 4-CN, 5-CF3) Ph(2-Cl, 3, 5-di-OCHF2, 4-Cl) Ph(2-Cl, 3-OCHF2, 4-F, 5-OCHF2) Ph(2-Cl, 3, 5-di-OCHF2, 4-Br) Ph(2-Cl, 3-OCHF2, 4-I, 5-OCHF2) Ph(2-Cl, 3, 5-di-OCHF2, 4-Me) Ph(2-Cl, 3, 5-di-OCHF2, 4-Et)

Ph(2-Cl, 3, 5-di-OCHF2, 4-n-Pr) Ph(2-Cl, 3, 5-di-OCHF2, 4-1-Bu) Ph(2-Cl, 3, 5- di-OCHF2, 4- i -Pr) Ph(2-Cl, 3, 5-di-OCHF2, 4- c -Pr) Ph(2-Cl, 3, 5-di-OCHF2CF3, 4-CF3) Ph(2-Cl, 3-OC2F5, 4-C2F5, 5-OCHF2) Ph(2-Cl, 3, 5-di-OCHF2, 4-CF2CF2H) Ph(2-Cl, 3-OCHF2, 4-CF2H, 5- OCHF2) Ph(2-Cl, 3, 5-di OCHF2, 4-OMe)

Q

Ph(2-Cl, 3, 5-di-OCHF2, 4-OCF3) Ph(2-Cl, 3, 4, 5-tri-OCHF2)

Ph(2-Cl, 3-OCHF2, 4-OCF2CF2H, 5OCHF2)

Ph(2-Cl, 3-OCHF2, 4-OC2F5, 5OCHF2)

Ph(2-Cl, 3, 5-di-OCHF2, 4-SO2Me) Ph(2-Cl, 3, 5-di-OCHF2, 4-TMS) Ph(2-Cl, 3, 5-di-OCHF2, 4-CN) Ph(2-F, 3, 4, 5-tri-Cl) Ph(2-F, 3-Cl, 4-F, 5-Cl) Ph(2-F, 3-Cl, 4- Br, 5-Cl) Ph(2-F, 3-Cl, 4-I, 5-Cl) Ph(2-F, 3-Cl, 4-Me, 5-Cl) Ph(2-F, 3- Cl, 4-Et, 5-Cl) Ph(2-F, 3-Cl, 4-n-Pr, 5-Cl) Ph(2-F, 3-Cl, 4-1-Bu, 5-Cl) Ph(2-F, 3-Cl, 4- i -Pr, 5-Cl) Ph(2-F, 3-Cl, 4- c -Pr, 5-Cl) Ph(2-F, 3-Cl, 4-CF3, 5-Cl) Ph(2-F, 3-Cl, 4-C2F5, 5-Cl) Ph(2-F, 3-Cl, 4-CF2CF2H, 5-Cl) Ph(2-F, 3-Cl, 4-CF2H, 5-Cl) Ph(2-F, 3-Cl, 4-OMe, 5-Cl) Ph(2-F, 3-Cl, 4-OCF3, 5-Cl) Ph(2-F, 3-Cl, 4-OCHF2, 5-Cl) Ph(2-F, 3-Cl, 4-OCF2CF2H, 5-Cl) Ph(2-F, 3, 5-di-Cl, 4-OC2F5) Ph(2-F, 3-Cl, 4-SO2Me, 5-Cl) Ph(2-F, 3-Cl, 4-TMS, 5-Cl) Ph(2-F, 3-Cl, 4-CN, 5-Cl) Ph(2-F, 3-F, 4-Cl, 5-F) Ph(2, 3, 4, 5-tetra-F) Ph(2-F, 3-F, 4-Br, 5-F) Ph(2-F, 3-F, 4-I, 5-F) Ph(2-F, 3-F, 4-Me, 5-F) Ph(2-F, 3-F, 4-Et, 5-F) Ph(2-F, 3-F, 4-n-Pr, 5-F)

MD 4889 B1 2024.03.31

Q

Ph(2-F, 3-F, 4-1-Bu, 5-F) Ph(2-F, 3-F, 4- i -Pr, 5-F) Ph(2-F, 3-F, 4- c -Pr, 5-F) Ph(2-F, 3-F, 4-CF3, 5-F) Ph(2-F, 3-F, 4-C2F5, 5-F) Ph(2- F, 3-F, 4-CF2CF2H, 5-F) Ph(2-F, 3-F, 4-CF2H, 5-F) Ph(2-F, 3-F, 4-OMe, 5-F) Ph(2-F, 3-F, 4-OCF3, 5-F) Ph(2-F, 3-F, 4-OCHF2, 5-F) Ph(2-F, 3-F, 4-OCF2CF2H, 5-F) Ph(2-F, 3-F, 4-OC2F5, 5-F) Ph(2-F, 3-F, 4-SO2Me, 5-F) Ph(2-F, 3-F, 4-TMS, 5-F) Ph(2-F, 3-F, 4-CN, 5-F)

Ph(2-F, 3-Br, 4-Cl, 5-Br) Ph(2-F, 3-Br, 4-F, 5-Br) Ph(2-F, 3, 4, 5-tri- Br) Ph(2-F, 3-Br, 4-I, 5-Br) Ph(2-F, 3-Br, 4-Me, 5-Br) Ph(2-F, 3-Br, 4- Et, 5-Br) Ph(2-F, 3-Br, 4-n-Pr, 5-Br) Ph(2-F, 3-Br, 4-1-Bu, 5-Br) Ph(2- F, 3-Br, 4- i -Pr, 5-Br) Ph(2-F, 3-Br, 4-c -Pr, 5-Br) Ph(2-F, 3-Br, 4-CF3, 5-Br) Ph(2-F, 3, 5-di-Br, 4-C2F5) Ph(2-F, 3-Br, 4-CF2CF2H, 5-Br) Ph(2-F, 3-Br, 4-CF2H, 5-Br) Ph(2-F, 3-Br, 4-OMe, 5-Br) Ph(2-F, 3-Br, 4-OCF3, 5-Br) Ph(2-F, 3-Br, 4-OCHF2, 5-Br) Ph(2-F, 3-Br, 4-OCF2CF2H, 5-Br) Ph(2-F, 3-Br, 4-OC2F5, 5-Br) Ph(2-F, 3-Br, 4-SO2Me, 5-Br) Ph(2-F, 3-Br, 4-TMS, 5-Br) Ph(2-F, 3-Br, 4-CN, 5-Br)

Q

Ph(2-F, 3-Me, 4-Cl, 5-Me) Ph(2-F, 3-Me, 4-F, 5-Me) Ph(2-F, 3-Me, 4-Br, 5-Me) Ph(2-F, 3-Me, 4-I, 5-Me) Ph(2-F, 3, 4-tri-Me)

Ph(2-F, 3-Me, 4-Et, 5-Me) Ph(2-F, 3-Me, 4-n-Pr, 5-Me) Ph(2-F, 3-Me, 4- t-Bu, 5-Me) Ph(2-F, 3-Me, 4-i -Pr, 5-Me) Ph(2-F, 3-Me, 4-c -Pr, 5-Me) Ph(2-F, 3-Me, 4-CF3, 5-Me) Ph(2-F, 3-Me, 4-C2F5, 5-Me) Ph(2-F, 3-Me, 4-CF2CF2H, 5- Me) Ph(2-F, 3-Me, 4-CF2H, 5-Me) Ph(2-F, 3-Me, 4-OMe, 5-Me) Ph(2-F, 3-Me, 4- OCF3, 5-Me) Ph(2-F, 3-Me, 4-OCHF2, 5-Me) Ph(2-F, 3-Me, 4-OCF2CF2H, 5-Me) Ph(2-F, 3- Me, 4-OC2F5, 5-Me) Ph(2-F, 3-Me, 4-SO2Me, 5-Me) Ph(2-F, 3-Me, 4-TMS, 5-Me) Ph(2- F, 3-Me, 4-CN, 5-Me) Ph(2-F, 3-CF3, 4-Cl, 5-CF3) Ph(2-F, 3-CF3, 4-F, 5-CF3) Ph(2-F, 3-CF3, 4-Br, 5-CF3) Ph(2-F, 3-CF3, 4-I, 5-CF3) Ph(2-F, 3-CF3, 4-Me, 5-CF3) Ph(2-F, 3-CF3, 4-Et, 5-CF3) Ph(2-F, 3-CF3, 4-n-Pr, 5-CF3) Ph(2-F, 3- CF3, 4-1-Bu, 5-CF3) Ph(2-F, 3-CF3, 4- i -Pr, 5-CF3) Ph(2-F, 3-CF3, 4-c -Pr, 5- CF3)

Ph(2-F, 3, 4, 5-tri-CF3) Ph(2-F, 3-CF3, 4-C2F5, 5-CF3) Ph(2-F, 3-CF3, 4-CF2CF2H, 5- CF3) Ph(2-F, 3-CF3, 4-CF2H, 5-CF3) Ph(2-F, 3-CF3, 4-OMe, 5-CF3)

Q

Ph(2-F, 3-CF3, 4-OCF3, 5-CF3)

Ph(2-F, 3-CF3, 4-OCHF2, 5-CF3) Ph(2-F, 3-CF3, 4-OCF2CF2H, 5-CF3) Ph(2-F, 3-CF3, 4-OC2F5, 5-CF3) Ph(2-F, 3-CF3, 4-SO2Me, 5-CF3)

Ph(2-F, 3-CF3, 4-TMS, 5-CF3)

Ph(2-F, 3-CF3, 4-CN, 5-CF3)

Ph(2-F, 3-OCHF2, 4-Cl, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-F, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-Br, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-I, 5-OCHF2)

Ph(2-F, 3-OCHF2, 4-Me, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-Et, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-n- Pr, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-1-Bu, 5-OCHF2) Ph(2-F, 3-OCHF2, 4- i -Pr, 5-OCHF2)

Ph(2-F, 3, 5-di-OCHF2, 4-c -Pr) Ph(2-F, 3-OCHF2CF3, 4-CF3, 5OCHF2)

Ph(2-F, 3-OC2F5, 4-C2F5, 5-OCHF2)

Ph(2-F, 3, 5-di-OCHF2, 4-CF2CF2H) Ph(2-F, 3-OCHF2, 4-CF2H, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-OMe, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-OCF3, 5-OCHF2)

Ph(2-F, 3, 4, 5-tri-OCHF2)

Ph(2-F, 3-OCHF2, 4-OCF2CF2H, 5OCHF2)

Ph(2-F, 3-OCHF2, 4-OC2F5, 5-OCHF2)

Ph(2-F, 3-OCHF2, 4-SO2Me, 5OCHF2)

Ph(2-F, 3-OCHF2, 4-TMS, 5-OCHF2) Ph(2-F, 3-OCHF2, 4-CN, 5-OCHF2) 1H-imidazol-2-yl(1-CF2CF2H, 5- Cl) 1H-imidazol-2-yl(1-CF2CF2H, 5-F) 1H-imidazol-2-yl(1-CH2CF3, 5-Cl) 1H-imidazol-2-yl(1-CH2CF3, 5-F) 1H-imidazol-2-yl(1-Me, 5-CF2H) 1H-imidazol-2-yl(1-CF2CF2H, 5MD 4889 B1 2024.03.31

<td>Q¹</td><td>Q¹ q¹</td>

<td>CF2H)</td><td>1,3-benzodioxol-4-yl 1H-pyrazol-3-yl(1-CH2CF3,4-F)</td>

1H-imidazol-2-yl(1-CH2CF3, 5-CF2H) i, 3-benzodioxol-4-yl(2, 2-di-Me) 1H-pyrazol-3-yl(1-CH2CF₃, 4-Cl)

1^HiMi^{dazol-2-yl(1-Me},^5-CF3⁾1, 4-Benzodioxol-4-yl(2, 3-dihydro) 1H-pyrazol-3-yl(1-CF2CF2H, 4-F)¹h^-IMi^{dazol-2-yl(1-CF}2^CF2^h,^5-CF3⁾1,4-benzodioxol-4-yl(2,2,3,3-1H-pyrazol-3-yl(1-CF2CF2H,4-Cl)¹h^-IMi^{dazol-2-yl(1-CH2CF3},^5-CF3)tetrafluoro) 1, 3-benzodioxol-4-yl(2, 2-di-F)

Table 2 is designed in the same way, except that the row heading “Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F); and Q¹is" is replaced by the row heading shown for Table 2 below (namely "Y¹is a; Y¹is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2, 3-F); and Q¹It is"). Therefore, the first entry in Table 2 is a compound of Formula 1 wherein Y¹is O, R²is H, R⁴is H, R⁵is H, Q²is Ph(2, 3-F); and Q¹is Ph(3-Cl) (namely 3-chlorophenyl). Tables 3 to 1699 are similarly designed.

<td>Table</td><td>The row title</td>

<td> 2</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-F); and Q¹It is</td>

<td> 3</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,4-di-F); and Q¹It is</td>

<td> 4</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,5-di-F); and Q¹It is</td>

<td> 5</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2, 3, 4-tri-F); and Q¹It is</td>

<td> 6</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2, 3, 5-tri-F); and Q¹It is</td>

<td> 7</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3,4,5-tetra-F); and Q¹It is</td>

<td> 8</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-Br); and Q¹It is</td>

<td> 9</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-F); and Q¹It is</td>

<td> 10</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Br, 4-F); and Q¹It is</td>

<td> 11</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me); and Q¹It is</td>

<td> 12</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-F); and Q¹It is</td>

<td> 13</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-Cl); and Q¹It is</td>

<td> 14</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl); and Q¹It is</td>

<td> 15</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Cl); and Q¹It is</td>

<td> 16</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F,3,4-di-Cl); and Q¹It is</td>

<td> 17</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Br); and Q¹It is</td>

<td> 18</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe); and Q¹It is</td>

<td> 19</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-F); and Q¹It is</td>

<td> 20</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-Cl); and Q¹It is</td>

<td> 21</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF2H); and Q¹It is</td>

<td> 22</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF₃); and Q¹It is</td>

<td> 23</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF₃, 4-F); and Q¹It is</td>

<td> 24</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2); and Q¹It is</td>

<td> 25</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2, 4-F); and Q¹It is</td>

<td> 26</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me); and Q¹It is</td>

<td> 27</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me, 4-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 28</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3); and Q¹It is</td>

<td> 29</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-F); and Q¹It is</td>

<td> 30</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-Me); and Q¹It is</td>

<td> 31</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-F); and Q¹It is</td>

<td> 32</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3-Cl); and Q¹It is</td>

<td> 33</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-Cl); and Q¹It is</td>

<td> 34</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3,4-di-F); and Q¹It is</td>

<td> 35</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H); and Q¹It is</td>

<td> 36</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3-F); and Q¹It is</td>

<td> 37</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Me); and Q¹It is</td>

<td> 38</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-F); and Q¹It is</td>

<td> 39</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Cl); and Q¹It is</td>

<td> 40</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-Cl); and Q¹It is</td>

<td> 41</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3,4-di-F); and Q¹It is</td>

<td> 42</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me); and Q¹It is</td>

<td> 43</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Me); and Q¹It is</td>

<td> 44</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-F); and Q¹It is</td>

<td> 45</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl); and Q¹It is</td>

<td> 46</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-CF3); and Q¹It is</td>

<td> 47</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-Cl); and Q¹It is</td>

<td> 48</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 49</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-Cl); and Q¹It is</td>

<td> 50</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-F); and Q¹It is</td>

<td> 51</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 5-F); and Q¹It is</td>

<td> 52</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-F); and Q¹It is</td>

<td> 53</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me-3, 5-di-F); and Q¹It is</td>

<td> 54</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et); and Q¹It is</td>

<td> 55</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-F); and Q¹It is</td>

<td> 56</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-Cl); and Q¹It is</td>

<td> 57</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 4-F); and Q¹It is</td>

<td> 58</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3, 4-di-F); and Q¹It is</td>

<td> 59</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr); and Q¹It is</td>

<td> 60</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3-F); and Q¹It is</td>

<td> 61</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3-Cl); and Q¹It is</td>

<td> 62</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 4-F); and Q¹It is</td>

<td> 63</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3, 4-di-F); and Q¹It is</td>

<td> 64</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 65</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3-F); and Q¹It is</td>

<td> 66</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3-Cl); and Q¹It is</td>

<td> 67</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 4-F); and Q¹It is</td>

<td> 68</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3, 4-di-F); and Q¹It is</td>

<td> 69</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2); and Q¹It is</td>

<td> 70</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-F); and Q¹It is</td>

<td> 71</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-Cl); and Q¹It is</td>

<td> 72</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 4-F); and Q¹It is</td>

<td> 73</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3, 4-di-F); and Q¹It is</td>

<td> 74</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCFs); and Q¹It is</td>

<td> 75</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 3-F); and Q¹It is</td>

<td> 76</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 4-F); and Q¹It is</td>

<td> 77</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl); and Q¹It is</td>

<td> 78</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me); and Q¹It is</td>

<td> 79</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me, 4-F); and Q¹It is</td>

<td> 80</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Cl); and Q¹It is</td>

<td> 81</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,4-di-Cl); and Q¹It is</td>

<td> 82</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-F); and Q¹It is</td>

<td> 83</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 4-F); and Q¹It is</td>

<td> 84</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 5-F); and Q¹It is</td>

<td> 85</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 4-di-F); and Q¹It is</td>

<td> 86</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 5-di-F); and Q¹It is</td>

<td> 87</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H); and Q¹It is</td>

<td> 88</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Me); and Q¹It is</td>

<td> 89</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Cl); and Q¹It is</td>

<td> 90</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-F); and Q¹It is</td>

<td> 91</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 4-F); and Q¹It is</td>

<td> 92</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H); and Q¹It is</td>

<td> 93</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 3-F); and Q¹It is</td>

<td> 94</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 4-F); and Q¹It is</td>

<td> 95</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br); and Q¹It is</td>

<td> 96</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3-F); and Q¹It is</td>

<td> 97</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 4-F); and Q¹It is</td>

<td> 98</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3, 4-di-F); and Q¹It is</td>

<td> 99</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I); and Q¹It is</td>

<td> 100</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 3-F); and Q¹It is</td>

<td> 101</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 4-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 102</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 3, 4-di-F); and Q¹It is</td>

<td> 103</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN); and Q¹It is</td>

<td> 104</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Me); and Q¹It is</td>

<td> 105</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-F); and Q¹It is</td>

<td> 106</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-F); and Q¹It is</td>

<td> 107</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Cl); and Q¹It is</td>

<td> 108</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-Cl); and Q¹It is</td>

<td> 109</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3, 4-di-F); and Q¹It is</td>

<td> 110</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl; and Q¹It is</td>

<td> 111</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-F; and Q¹It is</td>

<td> 112</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-F; and Q¹It is</td>

<td> 113</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3, 4-di-F; and Q¹It is</td>

<td> 114</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl; and Q¹It is</td>

<td> 115</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-Cl; and Q¹It is</td>

<td> 116</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl, 4-F; and Q¹It is</td>

<td> 117</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me); and Q¹It is</td>

<td> 118</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-F); and Q¹It is</td>

<td> 119</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Me); and Q¹It is</td>

<td> 120</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-F); and Q¹It is</td>

<td> 121</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 5-F); and Q¹It is</td>

<td> 122</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3, 4-di-F); and Q¹It is</td>

<td> 123</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl); and Q¹It is</td>

<td> 124</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-Cl); and Q¹It is</td>

<td> 125</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 132</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-F); and Q¹It is</td>

<td> 133</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,4-di-F); and Q¹It is</td>

<td> 134</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3, 5-di-F); and Q¹It is</td>

<td> 135</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3, 4, 5-tri-F); and Q¹It is</td>

<td> 136</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-F, 4-Cl); and Q¹It is</td>

<td> 137</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CFs); and Q¹It is</td>

<td> 138</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-F); and Q¹It is</td>

<td> 139</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-Cl); and Q¹It is</td>

<td> 140</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 5-F); and Q¹It is</td>

<td> 141</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 4, 5-di-F); and Q¹It is</td>

<td> 142</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me); and Q¹It is</td>

<td> 143</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-Cl); and Q¹It is</td>

<td> 144</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 145</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4, 5-di-F); and Q¹It is</td>

<td> 146</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 5-F); and Q¹It is</td>

<td> 152</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me); and Q¹It is</td>

<td> 153</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-F); and Q¹It is</td>

<td> 154</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-Cl); and Q¹It is</td>

<td> 155</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 5-F); and Q¹It is</td>

<td> 156</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4, 5-di-F); and Q¹It is</td>

<td> 157</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl); and Q¹It is</td>

<td> 158</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4-F); and Q¹It is</td>

<td> 159</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,4-di-Cl); and Q¹It is</td>

<td> 160</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 5-F); and Q¹It is</td>

<td> 161</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4, 5-di-F); and Q¹It is</td>

<td> 162</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,5-di-Cl); and Q¹It is</td>

<td> 163</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(4-F); and Q¹It is</td>

<td> 164</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(4-Cl); and Q¹It is</td>

<td> 165</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 166</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 167</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 168</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 169</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 170</td><td>Y¹is a; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 341</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F); and Q¹It is</td>

<td> 342</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-F); and Q¹It is</td>

<td> 343</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,4-di-F); and Q¹It is</td>

<td> 344</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,5-di-F); and Q¹It is</td>

<td> 345</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2, 3, 4-tri-F); and Q¹It is</td>

<td> 346</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2, 3, 5-tri-F); and Q¹It is</td>

<td> 347</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3,4,5-tetra-F); and Q¹It is</td>

<td> 348</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-Br); and Q¹It is</td>

<td> 349</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-F); and Q¹It is</td>

<td> 350</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Br, 4-F); and Q¹It is</td>

<td> 351</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me); and Q¹It is</td>

<td> 352</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-F); and Q¹It is</td>

<td> 353</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-Cl); and Q¹It is</td>

<td> 354</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl); and Q¹It is</td>

<td> 355</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Cl); and Q¹It is</td>

<td> 356</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F,3,4-di-Cl); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 357</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Br); and Q¹It is</td>

<td> 358</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe); and Q¹It is</td>

<td> 359</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-F); and Q¹It is</td>

<td> 360</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-Cl); and Q¹It is</td>

<td> 361</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF2H); and Q¹It is</td>

<td> 362</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CFs); and Q¹It is</td>

<td> 363</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF3, 4-F); and Q¹It is</td>

<td> 364</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2); and Q¹It is</td>

<td> 365</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2, 4-F); and Q¹It is</td>

<td> 366</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me); and Q¹It is</td>

<td> 367</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me, 4-F); and Q¹It is</td>

<td> 368</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3); and Q¹It is</td>

<td> 369</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-F); and Q¹It is</td>

<td> 370</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-Me); and Q¹It is</td>

<td> 371</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-F); and Q¹It is</td>

<td> 372</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3-Cl); and Q¹It is</td>

<td> 373</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-Cl); and Q¹It is</td>

<td> 374</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3,4-di-F); and Q¹It is</td>

<td> 375</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H); and Q¹It is</td>

<td> 376</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3-F); and Q¹It is</td>

<td> 377</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Me); and Q¹It is</td>

<td> 378</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-F); and Q¹It is</td>

<td> 379</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Cl); and Q¹It is</td>

<td> 380</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-Cl); and Q¹It is</td>

<td> 381</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3,4-di-F); and Q¹It is</td>

<td> 382</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me); and Q¹It is</td>

<td> 383</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Me); and Q¹It is</td>

<td> 384</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-F); and Q¹It is</td>

<td> 385</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl); and Q¹It is</td>

<td> 386</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-CF3); and Q¹It is</td>

<td> 387</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-Cl); and Q¹It is</td>

<td> 388</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 389</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-Cl); and Q¹It is</td>

<td> 390</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-F); and Q¹It is</td>

<td> 391</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 5-F); and Q¹It is</td>

<td> 392</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-F); and Q¹It is</td>

<td> 393</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me-3, 5-di-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 394</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et); and Q¹It is</td>

<td> 395</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-F); and Q¹It is</td>

<td> 396</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-Cl); and Q¹It is</td>

<td> 397</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 4-F); and Q¹It is</td>

<td> 398</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3, 4-di-F); and Q¹It is</td>

<td> 399</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr); and Q¹It is</td>

<td> 400</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3-F); and Q¹It is</td>

<td> 401</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3-Cl); and Q¹It is</td>

<td> 402</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 4-F); and Q¹It is</td>

<td> 403</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3, 4-di-F); and Q¹It is</td>

<td> 404</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr); and Q¹It is</td>

<td> 405</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3-F); and Q¹It is</td>

<td> 406</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3-Cl); and Q¹It is</td>

<td> 407</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 4-F); and Q¹It is</td>

<td> 408</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3, 4-di-F); and Q¹It is</td>

<td> 409</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2); and Q¹It is</td>

<td> 410</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-F); and Q¹It is</td>

<td> 411</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-Cl); and Q¹It is</td>

<td> 412</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 4-F); and Q¹It is</td>

<td> 413</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3, 4-di-F); and Q¹It is</td>

<td> 414</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCFs); and Q¹It is</td>

<td> 415</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 3-F); and Q¹It is</td>

<td> 416</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 4-F); and Q¹It is</td>

<td> 417</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl); and Q¹It is</td>

<td> 418</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me); and Q¹It is</td>

<td> 419</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me, 4-F); and Q¹It is</td>

<td> 420</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Cl); and Q¹It is</td>

<td> 421</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,4-di-Cl); and Q¹It is</td>

<td> 422</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-F); and Q¹It is</td>

<td> 423</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 4-F); and Q¹It is</td>

<td> 424</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 5-F); and Q¹It is</td>

<td> 425</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 4-di-F); and Q¹It is</td>

<td> 426</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 5-di-F); and Q¹It is</td>

<td> 427</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H); and Q¹It is</td>

<td> 428</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Me); and Q¹It is</td>

<td> 429</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Cl); and Q¹It is</td>

<td> 430</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 431</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 4-F); and Q¹It is</td>

<td> 432</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H); and Q¹It is</td>

<td> 433</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 3-F); and Q¹It is</td>

<td> 434</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 4-F); and Q¹It is</td>

<td> 435</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br); and Q¹It is</td>

<td> 436</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3-F); and Q¹It is</td>

<td> 437</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 4-F); and Q¹It is</td>

<td> 438</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3, 4-di-F); and Q¹It is</td>

<td> 439</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I); and Q¹It is</td>

<td> 440</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 3-F); and Q¹It is</td>

<td> 441</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 4-F); and Q¹It is</td>

<td> 442</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 3, 4-di-F); and Q¹It is</td>

<td> 443</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN); and Q¹It is</td>

<td> 444</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Me); and Q¹It is</td>

<td> 445</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-F); and Q¹It is</td>

<td> 446</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-F); and Q¹It is</td>

<td> 447</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Cl); and Q¹It is</td>

<td> 448</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-Cl); and Q¹It is</td>

<td> 449</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3, 4-di-F); and Q¹It is</td>

<td> 450</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl; and Q¹It is</td>

<td> 451</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-F; and Q¹It is</td>

<td> 452</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-F; and Q¹It is</td>

<td> 453</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3, 4-di-F; and Q¹It is</td>

<td> 454</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl; and Q¹It is</td>

<td> 455</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-Cl; and Q¹It is</td>

<td> 456</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl, 4-F; and Q¹It is</td>

<td> 457</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me); and Q¹It is</td>

<td> 458</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-F); and Q¹It is</td>

<td> 459</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Me); and Q¹It is</td>

<td> 460</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-F); and Q¹It is</td>

<td> 461</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 5-F); and Q¹It is</td>

<td> 462</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3, 4-di-F); and Q¹It is</td>

<td> 463</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl); and Q¹It is</td>

<td> 464</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-Cl); and Q¹It is</td>

<td> 465</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 472</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-F); and Q¹It is</td>

<td> 473</td><td>Y¹is a; Y²it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,4-di-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 474</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3, 5-di-F); and Q¹It is</td>

<td> 475</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3, 4, 5-tri-F); and Q¹It is</td>

<td> 476</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-F, 4-Cl); and Q¹It is</td>

<td> 477</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CFs); and Q¹It is</td>

<td> 478</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-F); and Q¹It is</td>

<td> 479</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-Cl); and Q¹It is</td>

<td> 480</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 5-F); and Q¹It is</td>

<td> 481</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 4, 5-di-F); and Q¹It is</td>

<td> 482</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me); and Q¹It is</td>

<td> 483</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-Cl); and Q¹It is</td>

<td> 484</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-F); and Q¹It is</td>

<td> 485</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4, 5-di-F); and Q¹It is</td>

<td> 486</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 5-F); and Q¹It is</td>

<td> 492</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me); and Q¹It is</td>

<td> 493</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-F); and Q¹It is</td>

<td> 494</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-Cl); and Q¹It is</td>

<td> 495</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 5-F); and Q¹It is</td>

<td> 496</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4, 5-di-F); and Q¹It is</td>

<td> 497</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl); and Q¹It is</td>

<td> 498</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4-F); and Q¹It is</td>

<td> 499</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,4-di-Cl); and Q¹It is</td>

<td> 500</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 5-F); and Q¹It is</td>

<td> 501</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4, 5-di-F); and Q¹It is</td>

<td> 502</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,5-di-Cl); and Q¹It is</td>

<td> 503</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(4-F); and Q¹It is</td>

<td> 504</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is Ph(4-Cl); and Q¹It is</td>

<td> 505</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 506</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 507</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 508</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 509</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 510</td><td>Y¹is a; Y</td><td>it is s; R²is H; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 681</td><td>Y¹is NH;</td><td>Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F); and Q¹It is</td>

<td> 682</td><td>Y¹is NH;</td><td>Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-F); and Q¹It is</td>

<td> 683</td><td>Y¹is NH;</td><td>Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,4-di-F); and Q¹It is</td>

<td> 684</td><td>Y¹is NH;</td><td>Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,5-di-F); and Q¹It is</td>

<td> 685</td><td>Y¹is NH;</td><td>Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2, 3, 4-tri-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 686</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2, 3, 5-tri-F); and Q¹It is</td>

<td> 687</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3,4,5-tetra-F); and Q¹It is</td>

<td> 688</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-Br); and Q¹It is</td>

<td> 689</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-F); and Q¹It is</td>

<td> 690</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Br, 4-F); and Q¹It is</td>

<td> 691</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me); and Q¹It is</td>

<td> 692</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-F); and Q¹It is</td>

<td> 693</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-Cl); and Q¹It is</td>

<td> 694</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl); and Q¹It is</td>

<td> 695</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Cl); and Q¹It is</td>

<td> 696</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F,3,4-di-Cl); and Q¹It is</td>

<td> 697</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Br); and Q¹It is</td>

<td> 698</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe); and Q¹It is</td>

<td> 699</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-F); and Q¹It is</td>

<td> 700</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-Cl); and Q¹It is</td>

<td> 701</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF2H); and Q¹It is</td>

<td> 702</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CFs); and Q¹It is</td>

<td> 703</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF3, 4-F); and Q¹It is</td>

<td> 704</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2); and Q¹It is</td>

<td> 705</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2, 4-F); and Q¹It is</td>

<td> 706</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me); and Q¹It is</td>

<td> 707</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me, 4-F); and Q¹It is</td>

<td> 708</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3); and Q¹It is</td>

<td> 709</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-F); and Q¹It is</td>

<td> 710</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-Me); and Q¹It is</td>

<td> 711</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-F); and Q¹It is</td>

<td> 712</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3-Cl); and Q¹It is</td>

<td> 713</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-Cl); and Q¹It is</td>

<td> 714</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3,4-di-F); and Q¹It is</td>

<td> 715</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H); and Q¹It is</td>

<td> 716</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3-F); and Q¹It is</td>

<td> 717</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Me); and Q¹It is</td>

<td> 718</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-F); and Q¹It is</td>

<td> 719</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Cl); and Q¹It is</td>

<td> 720</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-Cl); and Q¹It is</td>

<td> 721</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3,4-di-F); and Q¹It is</td>

<td> 722</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 723</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Me); and Q¹It is</td>

<td> 724</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-F); and Q¹It is</td>

<td> 725</td><td>Y¹is NH; Y</td><td> '²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl); and Q¹It is</td>

<td> 726</td><td>Y¹is NH; Y</td><td> '²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-CFs); and Q¹It is</td>

<td> 727</td><td>Y¹is NH; Y</td><td> '²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-Cl); and Q¹It is</td>

<td> 728</td><td>Y¹is NH; Y</td><td> '²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 729</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-Cl); and Q¹It is</td>

<td> 730</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-F); and Q¹It is</td>

<td> 731</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 5-F); and Q¹It is</td>

<td> 732</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-F); and Q¹It is</td>

<td> 733</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 5-di-F); and Q¹It is</td>

<td> 734</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et); and Q¹It is</td>

<td> 735</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-F); and Q¹It is</td>

<td> 736</td><td>Y¹is NH; Y</td><td>^,2is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-Cl); and Q¹It is</td>

<td> 737</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 4-F); and Q¹It is</td>

<td> 738</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3, 4-di-F); and Q¹It is</td>

<td> 739</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr); and Q¹It is</td>

<td> 740</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3-F); and Q¹It is</td>

<td> 741</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3-Cl); and Q¹It is</td>

<td> 742</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 4-F); and Q¹It is</td>

<td> 743</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3, 4-di-F); and Q¹It is</td>

<td> 744</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr); and Q¹It is</td>

<td> 745</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3-F); and Q¹It is</td>

<td> 746</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3-Cl); and Q¹It is</td>

<td> 747</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 4-F); and Q¹It is</td>

<td> 748</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3, 4-di-F); and Q¹It is</td>

<td> 749</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2); and Q¹It is</td>

<td> 750</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-F); and Q¹It is</td>

<td> 751</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-Cl); and Q¹It is</td>

<td> 752</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 4-F); and Q¹It is</td>

<td> 753</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3, 4-di-F); and Q¹It is</td>

<td> 754</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCFs); and Q¹It is</td>

<td> 755</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 3-F); and Q¹It is</td>

<td> 756</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 4-F); and Q¹It is</td>

<td> 757</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl); and Q¹It is</td>

<td> 758</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me); and Q¹It is</td>

<td> 759</td><td>Y¹is NH; Y</td><td>²²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me, 4-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 760</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Cl); and Q¹It is</td>

<td> 761</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2,4-di-Cl); and Q¹It is</td>

<td> 762</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-F); and Q¹It is</td>

<td> 763</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 4-F); and Q¹It is</td>

<td> 764</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 5-F); and Q¹It is</td>

<td> 765</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 4-di-F); and Q¹It is</td>

<td> 766</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 5-di-F); and Q¹It is</td>

<td> 767</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H); and Q¹It is</td>

<td> 768</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Me); and Q¹It is</td>

<td> 769</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Cl); and Q¹It is</td>

<td> 770</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-F); and Q¹It is</td>

<td> 771</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 4-F); and Q¹It is</td>

<td> 772</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H); and Q¹It is</td>

<td> 773</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 3-F); and Q¹It is</td>

<td> 774</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 4-F); and Q¹It is</td>

<td> 775</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br); and Q¹It is</td>

<td> 776</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3-F); and Q¹It is</td>

<td> 777</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 4-F); and Q¹It is</td>

<td> 778</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3, 4-di-F); and Q¹It is</td>

<td> 779</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I); and Q¹It is</td>

<td> 780</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 3-F); and Q¹It is</td>

<td> 781</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 4-F); and Q¹It is</td>

<td> 782</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-I, 3, 4-di-F); and Q¹It is</td>

<td> 783</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN); and Q¹It is</td>

<td> 784</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Me); and Q¹It is</td>

<td> 785</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-F); and Q¹It is</td>

<td> 786</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-F); and Q¹It is</td>

<td> 787</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Cl); and Q¹It is</td>

<td> 788</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-Cl); and Q¹It is</td>

<td> 789</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3, 4-di-F); and Q¹It is</td>

<td> 790</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl; and Q¹It is</td>

<td> 791</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-F; and Q¹It is</td>

<td> 792</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-F; and Q¹It is</td>

<td> 793</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3, 4-di-F; and Q¹It is</td>

<td> 794</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl; and Q¹It is</td>

<td> 795</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-Cl; and Q¹It is</td>

<td> 796</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl, 4-F; and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 797</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me); and Q¹It is</td>

<td> 798</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-F); and Q¹It is</td>

<td> 799</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Me); and Q¹It is</td>

<td> 800</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-F); and Q¹It is</td>

<td> 801</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 5-F); and Q¹It is</td>

<td> 802</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3, 4-di-F); and Q¹It is</td>

<td> 803</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl); and Q¹It is</td>

<td> 804</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-Cl); and Q¹It is</td>

<td> 805</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 812</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-F); and Q¹It is</td>

<td> 813</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,4-di-F); and Q¹It is</td>

<td> 814</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3, 5-di-F); and Q¹It is</td>

<td> 815</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3, 4, 5-tri-F); and Q¹It is</td>

<td> 816</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-F, 4-Cl); and Q¹It is</td>

<td> 817</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CFs); and Q¹It is</td>

<td> 818</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-F); and Q¹It is</td>

<td> 819</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-Cl); and Q¹It is</td>

<td> 820</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 5-F); and Q¹It is</td>

<td> 821</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 4, 5-di-F); and Q¹It is</td>

<td> 822</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me); and Q¹It is</td>

<td> 823</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-Cl); and Q¹It is</td>

<td> 824</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-F); and Q¹It is</td>

<td> 825</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4, 5-di-F); and Q¹It is</td>

<td> 826</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 5-F); and Q¹It is</td>

<td> 832</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me); and Q¹It is</td>

<td> 833</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-F); and Q¹It is</td>

<td> 834</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-Cl); and Q¹It is</td>

<td> 835</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Me, 5-F); and Q¹It is</td>

<td> 836</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Mr, 4, 5-di-F); and Q¹It is</td>

<td> 837</td><td>Y¹is NH; Y</td><td>'2 is O; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl); and Q¹It is</td>

<td> 838</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4-F); and Q¹It is</td>

<td> 839</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,4-di-Cl); and Q¹It is</td>

<td> 840</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 5-F); and Q¹It is</td>

<td> 841</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4, 5-di-F); and Q¹It is</td>

<td> 842</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(3,5-di-Cl); and Q¹It is</td>

<td> 843</td><td>Y¹is NH; Y</td><td>^,:is a; R²is H; R⁴is H; R⁵is H; Q²is Ph(4-F); and Q¹It is</td>

<td> 844</td><td>Y¹is NH; Y</td><td>^Лis a; R²is H; R⁴is H; R⁵is H; Q²is Ph(4-Cl); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 845</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-4-yl; and Q'est</td>

<td> 846</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-5-yl; and Q'est</td>

<td> 847</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 848</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 849</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 850</td><td>Y¹is NH; Y²is a; R²is H; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 851</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F); and Q¹It is</td>

<td> 852</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2,3-di-F); and Q¹It is</td>

<td> 853</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2,4-di-F); and Q¹It is</td>

<td> 854</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2,5-di-F); and Q¹It is</td>

<td> 855</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2, 3, 4-tri-F); and Q¹It is</td>

<td> 856</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2, 3, 5-tri-F); and Q¹It is</td>

<td> 857</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2,3,4,5-tetra-F); and Q¹It is</td>

<td> 858</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-Br); and Q¹It is</td>

<td> 859</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-F); and Q¹It is</td>

<td> 860</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Br, 4-F); and Q¹It is</td>

<td> 861</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me); and Q¹It is</td>

<td> 862</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-F); and Q¹It is</td>

<td> 863</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Me, 4-Cl); and Q¹It is</td>

<td> 864</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-Cl); and Q¹It is</td>

<td> 865</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Cl); and Q¹It is</td>

<td> 866</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F,3,4-di-Cl); and Q¹It is</td>

<td> 867</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 4-Br); and Q¹It is</td>

<td> 868</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe); and Q¹It is</td>

<td> 869</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-F); and Q¹It is</td>

<td> 870</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-Cl); and Q¹It is</td>

<td> 871</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF2H); and Q¹It is</td>

<td> 872</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CFs); and Q¹It is</td>

<td> 873</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-CF3, 4-F); and Q¹It is</td>

<td> 874</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2); and Q¹It is</td>

<td> 875</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-NO2, 4-F); and Q¹It is</td>

<td> 876</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me); and Q¹It is</td>

<td> 877</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-F, 3-SO2Me, 4-F); and Q¹It is</td>

<td> 878</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF3); and Q¹It is</td>

<td> 879</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-F); and Q¹It is</td>

<td> 880</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF3, 3-Me); and Q¹It is</td>

<td> 881</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 882</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3-Cl); and Q¹It is</td>

<td> 883</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF3,4-Cl); and Q¹It is</td>

<td> 884</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF3,3,4-di-F); and Q¹It is</td>

<td> 885</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF2H); and Q¹It is</td>

<td> 886</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3-F); and Q¹It is</td>

<td> 887</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Me); and Q¹It is</td>

<td> 888</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-F); and Q¹It is</td>

<td> 889</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 3-Cl); and Q¹It is</td>

<td> 890</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF2H, 4-Cl); and Q¹It is</td>

<td> 891</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CF2H,3,4-di-F); and Q¹It is</td>

<td> 892</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me); and Q¹It is</td>

<td> 893</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Me); and Q¹It is</td>

<td> 894</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-F); and Q¹It is</td>

<td> 895</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl); and Q¹It is</td>

<td> 896</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-CF3); and Q¹It is</td>

<td> 897</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-Cl); and Q¹It is</td>

<td> 898</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 899</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-Cl); and Q¹It is</td>

<td> 900</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 4-F); and Q¹It is</td>

<td> 901</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 5-F); and Q¹It is</td>

<td> 902</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 4-di-F); and Q¹It is</td>

<td> 903</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Me, 3, 5-di-F); and Q¹It is</td>

<td> 904</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Et); and Q¹It is</td>

<td> 905</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-F); and Q¹It is</td>

<td> 906</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3-Cl); and Q¹It is</td>

<td> 907</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Et, 4-F); and Q¹It is</td>

<td> 908</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Et, 3, 4-di-F); and Q¹It is</td>

<td> 909</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-i -Pr); and Q¹It is</td>

<td> 910</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-i -Pr, 3-F); and Q¹It is</td>

<td> 911</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2- i -Pr, 3-Cl); and Q¹It is</td>

<td> 912</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-i -Pr, 4-F); and Q¹It is</td>

<td> 913</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-i-Pr, 3, 4-di-F); and Q¹It is</td>

<td> 914</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-c-Pr); and Q¹It is</td>

<td> 915</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-c-Pr, 3-F); and Q¹It is</td>

<td> 916</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3-Cl); and Q¹It is</td>

<td> 917</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-c-Pr, 4-F); and Q¹It is</td>

<td> 918</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2- c -Pr, 3, 4-di-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 919</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-NO2); and Q¹It is</td>

<td> 920</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-F); and Q¹It is</td>

<td> 921</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3-Cl); and Q¹It is</td>

<td> 922</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 4-F); and Q¹It is</td>

<td> 923</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-NO2, 3, 4-di-F); and Q¹It is</td>

<td> 924</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCFs); and Q¹It is</td>

<td> 925</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 3-F); and Q¹It is</td>

<td> 926</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF3, 4-F); and Q¹It is</td>

<td> 927</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl); and Q¹It is</td>

<td> 928</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me); and Q¹It is</td>

<td> 929</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-Me, 4-F); and Q¹It is</td>

<td> 930</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2,3-di-Cl); and Q¹It is</td>

<td> 931</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2,4-di-Cl); and Q¹It is</td>

<td> 932</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3-F); and Q¹It is</td>

<td> 933</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 4-F); and Q¹It is</td>

<td> 934</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 5-F); and Q¹It is</td>

<td> 935</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 4-di-F); and Q¹It is</td>

<td> 936</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Cl, 3, 5-di-F); and Q¹It is</td>

<td> 937</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H); and Q¹It is</td>

<td> 938</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Me); and Q¹It is</td>

<td> 939</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-Cl); and Q¹It is</td>

<td> 940</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 3-F); and Q¹It is</td>

<td> 941</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2H, 4-F); and Q¹It is</td>

<td> 942</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H); and Q¹It is</td>

<td> 943</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 3-F); and Q¹It is</td>

<td> 944</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-OCF2CF2H, 4-F); and Q¹It is</td>

<td> 945</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Br); and Q¹It is</td>

<td> 946</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3-F); and Q¹It is</td>

<td> 947</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Br, 4-F); and Q¹It is</td>

<td> 948</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-Br, 3, 4-di-F); and Q¹It is</td>

<td> 949</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-I); and Q¹It is</td>

<td> 950</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-I, 3-F); and Q¹It is</td>

<td> 951</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-I, 4-F); and Q¹It is</td>

<td> 952</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-I, 3, 4-di-F); and Q¹It is</td>

<td> 953</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CN); and Q¹It is</td>

<td> 954</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Me); and Q¹It is</td>

<td> 955</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 956</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-F); and Q¹It is</td>

<td> 957</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3-Cl); and Q¹It is</td>

<td> 958</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CN, 4-Cl); and Q¹It is</td>

<td> 959</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-CN, 3, 4-di-F); and Q¹It is</td>

<td> 960</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2-pyridinyl; and Q¹It is</td>

<td> 961</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-F; and Q¹It is</td>

<td> 962</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-F; and Q¹It is</td>

<td> 963</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3, 4-di-F; and Q¹It is</td>

<td> 964</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl; and Q¹It is</td>

<td> 965</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 4-Cl; and Q¹It is</td>

<td> 966</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2-pyridinyl, 3-Cl, 4-F; and Q¹It is</td>

<td> 967</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me); and Q¹It is</td>

<td> 968</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-F); and Q¹It is</td>

<td> 969</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Me); and Q¹It is</td>

<td> 970</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-F); and Q¹It is</td>

<td> 971</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 5-F); and Q¹It is</td>

<td> 972</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3, 4-di-F); and Q¹It is</td>

<td> 973</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl); and Q¹It is</td>

<td> 974</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 4-Cl); and Q¹It is</td>

<td> 975</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(2-SO2Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 982</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-F); and Q¹It is</td>

<td> 983</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3,4-di-F); and Q¹It is</td>

<td> 984</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3, 5-di-F); and Q¹It is</td>

<td> 985</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3, 4, 5-tri-F); and Q¹It is</td>

<td> 986</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-F, 4-Cl); and Q¹It is</td>

<td> 987</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-CFs); and Q¹It is</td>

<td> 988</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-F); and Q¹It is</td>

<td> 989</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-CF3,4-Cl); and Q¹It is</td>

<td> 990</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 5-F); and Q¹It is</td>

<td> 991</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-CF3, 4, 5-di-F); and Q¹It is</td>

<td> 992</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me); and Q¹It is</td>

<td> 993</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-Cl); and Q¹It is</td>

<td> 994</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4-F); and Q¹It is</td>

<td> 995</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 4, 5-di-F); and Q¹It is</td>

<td> 996</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-SO2Me, 5-F); and Q¹It is</td>

<td> 1002</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Me); and Q¹It is</td>

<td> 1003</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-F); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 1004</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4-Cl); and Q¹It is</td>

<td> 1005</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Me, 5-F); and Q¹It is</td>

<td> 1006</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Me, 4, 5-di-F); and Q¹It is</td>

<td> 1007</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Cl); and Q¹It is</td>

<td> 1008</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4-F); and Q¹It is</td>

<td> 1009</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3,4-di-Cl); and Q¹It is</td>

<td> 1010</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 5-F); and Q¹It is</td>

<td> 1011</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3-Cl, 4, 5-di-F); and Q¹It is</td>

<td> 1012</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(3,5-di-Cl); and Q¹It is</td>

<td> 1013</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(4-F); and Q¹It is</td>

<td> 1014</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is Ph(4-Cl); and Q¹It is</td>

<td> 1015</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 1016</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 1017</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 1018</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 1019</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-4-yl; and Q¹It is</td>

<td> 1020</td><td>Y¹is a; Y²is a; R²it is Me; R⁴is H; R⁵is H; Q²is 1,3-benzodioxol-5-yl; and Q¹It is</td>

<td> 1021</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F); and Q¹It is</td>

<td> 1022</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2,3-di-F); and Q¹It is</td>

<td> 1023</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2,4-di-F); and Q¹It is</td>

<td> 1024</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2,5-di-F); and Q¹It is</td>

<td> 1025</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2, 3, 4-tri-F); and Q¹It is</td>

<td> 1026</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2, 3, 5-tri-F); and Q¹It is</td>

<td> 1027</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2,3,4,5-tetra-F); and Q¹It is</td>

<td> 1028</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-Br); and Q¹It is</td>

<td> 1029</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-Cl, 4-F); and Q¹It is</td>

<td> 1030</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-Br, 4-F); and Q¹It is</td>

<td> 1031</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-Me); and Q¹It is</td>

<td> 1032</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-Me, 4-F); and Q¹It is</td>

<td> 1033</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-Me, 4-Cl); and Q¹It is</td>

<td> 1034</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-Cl); and Q¹It is</td>

<td> 1035</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 4-Cl); and Q¹It is</td>

<td> 1036</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F,3,4-di-Cl); and Q¹It is</td>

<td> 1037</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 4-Br); and Q¹It is</td>

<td> 1038</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-OMe); and Q¹It is</td>

<td> 1039</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-F); and Q¹It is</td>

<td> 1040</td><td>Y¹is a; Y²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-OMe, 4-Cl); and Q¹It is</td>

MD 4889 B1 2024.03.31

<td> 1041</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-CF2H); and Q¹It is</td>

<td> 1042</td><td>Y¹is a; Y</td><td> '²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-CFs); and Q¹It is</td>

<td> 1043</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-CF3, 4-F); and Q¹It is</td>

<td> 1044</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-NO2); and Q¹It is</td>

<td> 1045</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-NO2, 4-F); and Q¹It is</td>

<td> 1046</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-SO2Me); and Q¹It is</td>

<td> 1047</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-F, 3-SO2Me, 4-F); and Q¹It is</td>

<td> 1048</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF3); and Q¹It is</td>

<td> 1049</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF3, 3-F); and Q¹It is</td>

<td> 1050</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF3, 3-Me); and Q¹It is</td>

<td> 1051</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF3,4-F); and Q¹It is</td>

<td> 1052</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF3,3-Cl); and Q¹It is</td>

<td> 1053</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF3,4-Cl); and Q¹It is</td>

<td> 1054</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF3,3,4-di-F); and Q¹It is</td>

<td> 1055</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF2H); and Q¹It is</td>

<td> 1056</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF2H,3-F); and Q¹It is</td>

<td> 1057</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF2H, 3-Me); and Q¹It is</td>

<td> 1058</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF2H, 4-F); and Q¹It is</td>

<td> 1059</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF2H, 3-Cl); and Q¹It is</td>

<td> 1060</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF2H, 4-Cl); and Q¹It is</td>

<td> 1061</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-CF2H,3,4-di-F); and Q¹It is</td>

<td> 1062</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me); and Q¹It is</td>

<td> 1063</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2,3-di-Me); and Q¹It is</td>

<td> 1064</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 3-F); and Q¹It is</td>

<td> 1065</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 3-Cl); and Q¹It is</td>

<td> 1066</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 3-CF3); and Q¹It is</td>

<td> 1067</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 3, 4, di-Cl); and Q¹It is</td>

<td> 1068</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 3-Cl, 4-F); and Q¹It is</td>

<td> 1069</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 4-Cl); and Q¹It is</td>

<td> 1070</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 4-F); and Q¹It is</td>

<td> 1071</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 5-F); and Q¹It is</td>

<td> 1072</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 3, 4-di-F); and Q¹It is</td>

<td> 1073</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Me, 3, 5-di-F); and Q¹It is</td>

<td> 1074</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Et); and Q¹It is</td>

<td> 1075</td><td>Y¹is a; Y</td><td>²²is a; R²is H; R⁴is Br; R⁵is H; Q²is Ph(2-Et, 3-F); and Q¹It is</td>