Chewing gum with bleaching effect (variants)

Description:

The invention relates to the production of chewing gums with a bleaching effect, which also possess curative-prophylactic action, which can be used for the care and treatment of the oral cavity.

Known chewing gum, which confines the greasy ingredients,% mas .: polymeric base 20 ... 40; silicon dioxide 0.5 ... 3.0; water-soluble zinc salt, which ensures the presence in the composition of 0.01 ... 1.00% by mass. of zinc ions, and the rest plasticizer, sweetener and flavoring [1].

The disadvantage of this chewing gum lies in the narrow spectral acfion, manifested only by the bleaching effect and the lack of prophylaxis effects of caries, the treatment of periodontal tissues and the oral cavity.

The problem solved by the invention is the creation of a chewing gum with a bleaching effect, which possesses prophylaxis properties of caries and contributes to the prophylaxis and treatment of the tissues of the periodontal and oral cavity.

The problem is solved by the fact that the chewing gum confines the greasy components in the ratio,% mas: polymeric base 20.0 ... 30.0; plasticizer 0.5 ... 3.0; abrasive material 0.2 .... 5.0; sweetener 50.0 ..65.0; flavoring 0.2 .. .0.5; fluorine ion source 2.0 ... 10.0; source of calcium ions 6.0 ... 8.0; water up to 5.0; cyanobacterial strain biomass extract Spirulina platensis recalculated for dry matter 0.05 .. .0.50.

О Another variant of chewing gum contains Flores Calendulae extract recalculated for dry matter 0.5 ... 3.0% mass, respecting the ratio of the other components indicated above.

The third variant of chewing gum contains cyanobacterial strain biomass extract Spirulina platensis recalculated for dry matter 0.05 ... 0.50% by mass. and extract of Flores Calendulae recalculated for dry matter 0.5 ... 3.0% mass, respecting the ratio of the other components indicated above.

The fourth variant of chewing gum contains cyanobacterial strain biomass extract Spirulina platensis recalculated for dry matter 0.05 ... 0.50% by mass. and root extract of Armoracia rusticana Lam recalculated for dry matter 0.05 ... 0.50% mass, respecting the ratio of the other components indicated above.

The fifth variant of chewing gum contains Flores Calendulae extract recalculated for dry matter 0.5 ... 3.0% by mass. and root extract of Armoracia rusticana Lam recalculated for dry matter 0.05 ... 0.50% mass, respecting the ratio of the other components indicated above.

Sixth variant of chewing gum contains cyanobacterial strain biomass extract Spirulinaplatensis recalculated for dry matter 0.05 ... 0.50% mass, Flores Calendulae extract recalculated for dry substance 0.5 ... 3.0% more . and root extract of Armoracia rusticana Lam recalculated for dry matter 0.05 ... 0.50% mass, respecting the ratio of the other components indicated above.

Each variant of chewing gum as a plasticizer can contain glycerin or relapsed; as abrasive material silicon dioxide, calcium carbonate, sodium bicarbonate, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dicalcium phosphate dihydrate, bentonite or combinations thereof; as a sweetener xylit and / or saccharin; as a fragrance odorant of mint or odorant of menthol, or odorant of vanillin, or odorant of anise; as a source of fluorinated anionite fluoride ions with particle sizes of 5-500 pm and humidity of 3-5% and / or sodium fluoride; as a source of calcium ions, calcium glycerophosphate and / or calcium gluconate. At the same time, chewing gum can further contain a soluble pyrophosphate of an alkali metal, 0.5 ... 7.0% by weight.

Chewing gum is especially useful for use in situations where brushing teeth is impossible or uncomfortable, for example, after breakfast, during travel or during working hours. Chewing gum with a bleaching effect removes stains from the teeth, helps maintain the white of the teeth, is useful and convenient to apply immediately after using the products, which cause dyeing of the teeth, such as coffee, tea, red wine, and tobacco.

In this field, chewing gums of different shapes are known - larnelna, prismatic block, pill, lighter or ball and different processes for obtaining them.

Silicon dioxide, used in obtaining variants of chewing gums, which whiten the children, according to the required invention, represent colloidal or sedimentary particles having the dimensions from 3 to 12 pm and the pH within the limits 4 ... 10, preferably, 6 ... 9, and a confined in the gutter of 5% mas.

Silicon dioxide, which can be used to carry out this invention, is produced under the name Zeodent DPI05 by JM Huber Co., Atlanta, GA 30327 and has a water content of 5% mass., With an average diameter of about 7 ... 10 pm, hardness after Einlehner 5, surface area after BET of 390 m²/ g, oil absorption of at least 70 cm³/ 199 g of silicon dioxide. This silicon dioxide demonstrates minimal tooth enamel.

Abrasive silicon dioxide can be used as an abrasive material for the production of chewing gum or in combination with other abrasive materials known for cutting pastes or polishing agents, including calcium carbonate, sodium bicarbonate, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dicalcium phosphate dihydrate, bentonite and other silicon materials or combinations thereof.

MD 3901 G2 2009.05.31

Saliva plays an important role in maintaining enamel homeostasis and decay prophylaxis: the saliva's buffer properties ensure the neutralization of organic acids, which dissolve in the oral cavity and in the dental plaque region. The mechanism of the participation of saliva in enamel homeostasis consists in saturating the dental plate with buffer systems and mineral substances. The source of tooth enamel remineralization is the supersaturation of saliva with calcium ions and phosphates. In addition, saliva cleanses the buccal cavity of food debris and contains proteins, which prevent the growth of colonies of cariogenic bacteria.

The sweeteners included in the composition of the chewing gum show an anti-bacterial effect, degrees of its antimicrobial action, increasing the buffering capacity of the saliva and decreasing the production of organic acids in the buccal cavity. If chewing gum does not contain sugars, but is made from sugar substitutes, then its use contributes to speeding up the sugar intake in the mouth and increasing the pH of the saliva. The use of chewing gum after eating contributes to a faster increase of the pH of the dental plate in the first minutes of chewing. This effect is to a greater extent expressed by the use of sugar substitutes, which are not subject to fermentation by bacteria in the oral cavity.

One of the main functions of chewing gum is to maintain a neutral or weak basic pH value of the environment in the oral cavity that determines the buffer properties of saliva, largely due to carbonates. Their concentration in unstimulated saliva is at the level of 1 mol / 1, and when using chewing gum it increases up to 15 mol / 1.

still another factor that increases the anti-aging properties of gum is fluoride and calcium salts.

In the process of demineralizing the surface of the tooth enamel, the teeth lose calcium and phosphates. During remineralization calcium and phosphates diffuse inside the tooth through saliva and are deposited in new material in the region destroyed by caries. Remineralization is a process of enrichment with calcium and phosphates of partially demineralized tissues through the formation of new mineral salts.

Calcium is a necessary component of remineralization, as is fluoride. To strengthen the hard tissues of the teeth in the composition of chewing gum, calcium gluconate is introduced, which is the source of calcium ions, necessary for the preservation and hardening of the tooth enamel. The remineralization effect of calcium gluconate is intensified in combination with fluorine compounds. The anti-fluoride action of fluorine is related to its ability to increase the enamel's resistance to decay, by forming fluorapatite. Also, fluorides signal the metabolism of the teeth, inhibit the growth of microorganisms in the oral cavity, minimize the formation of acids, which destroy the teeth, intensify the remineralization of the enamel.

The introduction into the composition of chewing gum as a source of fluoride ions of a cleaning ingredient and anionite under the fluoride foam and as a sweetener, for example, of xylite, increases the tooth's resistance to decay. The presence in the composition of the proposed chewing gum of the anionite ensures that the optimal concentration allowed by fluoride ions is maintained in the buccal cavity for 15 to 20 minutes with the increase of the cleaning action. The presence in the composition of the anionite chewing gum, preferably with the particle size of 5 ... 500 pm, increases the cleaning action of the chewing gum and at the same time improves its obtaining technology, because the resin also has the role of filling material, and the inclusion in Chewing gum as a sweetener, for example, xylite, contributes to the improvement of organoleptic properties and increases the resistance to decay.

The peculiarity of chewing gum is its use in addition to the traditional basic components for chewing gums of the extract of biomass of the cyanobacterial strain of Spirulina platensis and / or of the extract of Flores calendulae, both separately and in combination with the root extract of Armoracia rusticana Lam. The presence in the composition of the chewing gum of the extracts indicated within the limits of the required concentrations ensures a complex regenerative action, anti-inflammatory and caries prophylaxis. In addition, due to its bactericidal properties, the extract from the cyanobacterial strain of the cyanobacterium Spirulina platensis and the extract of Flores calendulae assume to some extent the function of preservative, which allows to increase the shelf life of chewing gums. The well-pronounced curative-prophylactic effect of the requested chewing gum variants is first and foremost conditioned by the wide spectrum of action of the components that fall within it, as well as by their synergistic action. The extract of the cyanobacterial strain of the cyanobacterium Spirulina platensis possesses antibacterial, anti-inflammatory, anti-edema, antioxidant, adaptogenic, anti-hypoxic action, restores microcirculation, increases the localized immunity, which allows it to act on the basic segments of the pathogenesis of the diseases of the cavity. Also, possessing membranomodulatory properties, it stimulates the detoxification processes, it does not signal the microflora of the buccal cavity, which leads to the normalization of the metabolism of the periodontal tissues at the cellular level. By stimulating a nonspecific segment of humoral protection, the inflammation of the tissues is reduced and the local immunity increases on account of the increased phagocytic activity of the leukocytes, increasing the content of lysozyme in saliva, distracting the lipid layer of the cells of the microbial membranes, lacking its resistance. The extract of Flores calendulae possesses anti-inflammatory, healing, bactericidal, analgesic and antiprariginous action. It also activates the immune system. The addition of chewing gum to the root extract of Armoracia rusticana Lam allows the local immunity to be intensified on account of phagocytosis activation by stimulating the formation of plasma cells. The extract from the roots of Armoracia rusticana Lam contains sinigrine glycoside, myosin ferment,

MD 3901 G2 2009.05.31 antibiotic substance lysozyme, carbohydrates, nitrogenous and colloidal substances, fats (up to 0.4%), vitamin C (up to 100 mg%), phytoncides and a mixture of mustard oils (up to 0 , 34%), comprising black mustard oil. Due to the ingredients indicated above, the root extract of Armoracia rusticana Lam intensifies the anti-inflammatory and immunocorrecting activity of other medicinal extracts, which are part of chewing gum.

In the claimed invention, the ingredients that are part of the chewing gum manifest a pronounced activity, having their own character, also new properties have appeared, for example, the fungicidal action, due to which the curative-prophylactic properties of the chewing gum have been intensified.

The use of chewing gum stimulates saliva secretion. in its composition increases the content of calcium ions, necessary for the remineralization of the tan tissues of the teeth, as well as of the bicarbonates necessary for the non-signaling of the pH in the oral cavity.

The result of the invention consists in the non-signaling of the metabolism in the oral cavity, the increase of the enamel resistance to decay and the intensification of its remineralization, the inhibition of the growth of pathogenic microorganisms, the diminution of the melting of the acids, which destroy the teeth, the increase of the local immunity, as well as the non-signaling of the cellular metabolism.

The advantage of the requested invention is that the variants of the chewing gum requested prevent the development of pathogenic bacteria, bleeding and inflammation of the gums, destabilize the non-microflora of the mouth, neutralize acid dissociation of sugars, contribute to the hardening of the gums and teeth. Chewing gums have bactericidal action on streptococci and staphylococci and a pronounced action on Candida albicans fungi. At the same time, chewing gums have a pronounced bleaching effect.

Recipes for chewing gums are well known and in addition to the polymer base also include plasticizers, sweeteners and flavorings. The basic materials of the gum, suitable for carrying out this invention, are well known in the art and include bases of natural, synthetic resins or mixtures thereof. Typical natural resins include natural rubber, gutta-percha, loops, jelutong, balata, caspian leches, sorva, gutakey, sorva, guttakey, crown, perillo or mixtures thereof. Typical synthetic resins or elastomers include butadienstyrene, polyisobutylene copolymers and isobutylenisopropenic copolymers. In the proposed invention, plasticizers commonly used in the compositions for chewing gums are acceptable, namely gelatine, paraffin and their mixtures in an amount of 0.5 ... 2.0% more. Glycerin or molasses were used as the most suitable plasticizer variant for the proposed invention.

The sweetener can be selected from a wide spectrum of substances. Powdered sweetening agents, such as maltose, partially hydrolyzed starch, solid substances in corn syrup, sugars substituting alcohols, such as sorbit, xylite, mannit and their mixtures, high intensity synthetic or high-grade synthetic sweetening agents, for example of saccharin, sodium cyclamate and salts similar to it, the acid free form of saccharin; dipeptide-based sweetening agents, such as methyl ester Laspartyl-L-phenylalanine and potassium acesulfam. The degree of use of the synthetic sweetener can vary widely and depends on such factors as the efficiency of the sweetener, its speed of separation, the required sweetness of the product, the content and type of the odorant used and the value motivation. The powdered sweetening agent is present in the composition for chewing gum according to the invention, in an amount of 50.0 ... 65.0% mas. As the best variant of the sweetener for this invention, xylite and / or saccharin are used.

In addition to the listed ingredients, gum compositions may also include common additives such as dyes, flavorings and other such substances. For example, titanium dioxide can be used as a dye. Different flavorings known in the art, including ethereal oils, such as cinnamon oil, peppermint, good thyme, menthol, birch, anise and the like may be used; natural fruit flavorings obtained from the essence of apples, pears, peaches, strawberries, cherries, apricots, oranges, melons, bananas and the like; flavorings obtained from coffee beans, cocoa and the like. Flavorings are included in the composition of chewing gums in concentrates of 0.2 ... 0.5% more.

The requested chewing gum is prepared as follows: in a stirring reactor with continuous stirring, the quantity is charged according to the receptacle at a temperature of 60 ... 70 ° C, the polymeric mass, which is mixed with plasticizer, in particular with glycerin or relay. The obtained mass is mixed well for 3 ... 5 min. Then, abrasive material, calcium ion source, sweetener, flavoring, fluoride ion source and one of the extracts listed above or their mixture are added to the continuous stirring. After this the obtained mass is subjected to melting. In the rolling mill, the chewing gum table is laminated, stretched in a continuous strip with a thickness of 30 ... 35 mm. Then with a cutting device the strip is cut transversely in portions with a length of 290 mm. This is the first stage of mass formation. The obtained strips are cooled for 25 ... 30 min to 34 ... 38 ° C. Then the second stage of mass formation is performed, which provides for its passage through an extruder and the depression in ribbon molds ends with a thickness of 10 ... 12 mm. The temperature of 30 ... 35 ° C in the extraderal cylinder is established during the treatment of the mass. The obtained strip is then subjected to the teapot in final products.

MD 3901 G2 2009.05.31

The chewing gum specimens have been approved under clinical conditions. Experiments were carried out in order to determine the action of the gum variants chosen on the color of the teeth and to stimulate the elimination of saliva in chewing. In the experiments 10 volunteers were trained, who chewed gum obtained according to examples 1 ... 10. Each specimen was tested for 20 min, collecting saliva over harmless time intervals without swallowing. The collected saliva samples were analyzed to determine the concentration of the active substances. Research has shown that for 10 to 12 minutes the concentration of active substances is sufficient for the action of remineralization, anti-inflammatory and anti-inflammatory on the tissues and organs of the oral cavity. The data obtained regarding the use by volunteers of different variants of the chewing gum requested showed that during the chewing of the gum there is a slow linear elimination of the active substances. Also, the safe reduction of the intensity of staining of the teeth, visually detected, was proven after 20 bites. These conclusions are also confined by the clinical observations. Each variant of chewing gum was proposed to 3 volunteers, who used it for 10 days. The repeated clinical research of the volunteers showed an obvious improvement of the condition of the periodontium and the mucosa of the oral cavity, as well as a bleaching of the teeth in all the people who participated in the experiment.

It has been established that the peak of saliva elimination when using chewing gum is observed more than one minute from the beginning of the chewing, reaching the speed of 5.0 ... 5.5 mVmin, which exceeds 10 ... 12 times the initial level of unstimulated secretion. .

After consuming the sweetener, already over 10 minutes of continuous chewing, the rate of secretion stimulation decreases to the characteristic indices for mechanical stimulation. The speed of secretion does not depend on the type of flavoring. The more intense the saliva flow, the higher the self-cleaning speed.

Thus, the curative-prophylactic action of chewing gum is based on the stimulation of saliva secretion, which contributes to the accelerated elimination of sugars from the oral cavity, increases the saliva pH, activates the remineralization of the enamel, as well as the anti-inflammatory and anti-inflammatory action.

Example L Weigh all components according to the receipt based on the calculation for 1 kg of ready-made product. It is charged to the reactor at 60 ° C under continuous stirring 27.0% by weight of the polymer base. and glycerol 2.0% by weight. The mixture obtained is stirred for 3 min. Then, in the mixture with continuous stirring, 5.0% mass silicon is introduced; xylit 52.5% mass .; odorant of renta 0.5% mas .; calcium glycerophosphate 6.0% by weight; anionite under fluoride foil 2.0% by mass. and 50 ml of aqueous extract of the cyanobacterial strain of Spirulina platensis cyanobacterium recalculated for dry matter 0.50% by mass. Then the table is subjected to formatting.

The chewing gum obtained is a homogeneous mass of white with a pleasant taste and smell of peppermint. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 2. Weigh all components according to the receipt based on the calculation for 1 kg of ready product. It is charged to the reactor at 70 ° C under continuous stirring 21.0% by weight of the polymer base. and molasses 1.5% more. The mixture obtained is stirred for 5 min. Then, with continuous stirring, 0.2% silicon dioxide is added; saccharin 53.8% mass .; odorant of 0.5% duck anise; calcium glycerophosphate 8.0% by weight; anionite under fluoride fonn 10.0% by mass .; dry extract from the cyanobacterial strain of cyanobacterium Spirulina platensis recalculated for dry matter 0.05% mas. and blue dye 0.5% by weight, dissolved in 50 ml of water. Then the table is subjected to melting.

The chewing gum obtained is a homogeneous mass of blue color with a pleasant taste and smell of anise. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 3. Weigh all the components according to the receipt based on the calculation for 1 kg of ready product. It is charged to the reactor at 60 ° C under continuous stirring 21.5% by weight. and glycerol 2.0% by weight. The mixture obtained is stirred for 3 min. Then 2.5% by mass of silicon dioxide is added to the mixture with continuous stirring; 2.5% more sodium bicarbonate; xylit 50.0% mass .; peppermint fragrance 0.5% by weight; calcium glycerophosphate 6.0% by weight; anionite under fluoride fonn 10.0% by mass. and 50 ml of Flores calendulae extract recalculated for dry matter 0.50% by mass. Then the table is subjected to melting.

The chewing gum obtained is a homogeneous mass of white with a pleasant taste and smell of peppermint. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 4. Weigh all components according to the receipt based on the calculation for 1 kg of ready product. Charge in the reactor at 70 ° C with continuous stirring 20.0% by weight. and molasses 0.5% by mass. The mixture obtained is stirred for 5 min. Then 2.5% by mass of silicon dioxide is added to the mixture with continuous stirring; 2.5% more sodium bicarbonate; saccharin 56.0% mass .; odorant of 0.5% duck anise; calcium glycerophosphate 8.0% by weight; anionite under fluoride foil 2.0% mass .; Flores calendulae extract recalculated for dry matter 3.0% mas. and blue dye 0.5% by weight, dissolved in 50 ml of water. Then the table is subjected to formatting.

MD 3901 G2 2009.05.31

The chewing gum obtained is a homogeneous mass of blue color with a pleasant taste and smell of anise. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 5. Weigh all components according to the receipt based on the calculation for 1 kg of ready product. Charge in the reactor at 60 ° C with continuous stirring 30.0% by weight. and glycerol 2.0% by weight. The mixture obtained is stirred for 3 min. Then, with continuous stirring, 0.2% silicon dioxide is added; xylit 51.3% mass .; odorant of renta 0.5% mas .; calcium gluconate 6.0% by weight; fluoride anionite 2.0% by mass .; 50 ml of aqueous extract of the cyanobacterial strain of Spirulina platensis cyanobacteria recalculated for dry matter 0.5% by mass. and extract of Flores calendulae recalculated for dry matter 3.0% mas. Then the table is subjected to formatting.

The chewing gum obtained represents a homogeneous white color with a pleasant taste and smell of peppermint. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 6. Weigh all components according to the receipt based on the calculation for 1 kg of ready-made product. Charge in the reactor at 70 ° C under continuous stirring 20.0% by weight. and molasses 1.5% more. The mixture obtained is stirred for 5 min. Then 2.5% by mass of silicon dioxide is added to the mixture with continuous stirring; sodium metaphosphate 2.5% by weight; saccharin 50.0% mass .; odorant of 0.5% duck anise; calcium gluconate 8.0% by weight; 10.0% by weight of sodium fluoride; dry biomass extract of cyanobacterial strain Spirulina platensis 0.5% mas .; root extract of Armoracia rusticana Lam 0.5% mas. and blue dye 0.5% by weight, dissolved in 50 ml of water. Then the table is subjected to formatting.

The chewing gum obtained is о homogeneous blue color with a pleasant taste and smell of anise. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 7. Weigh all components according to the receipt based on the calculation for 1 kg of ready product. Charge in the reactor at 60 ° C with continuous stirring 30.0% by weight. and glycerol 2.0% by weight. The mixture obtained is stirred for 3 min. Then 0.25% more silicon dioxide is added to the stirring mixture; dicalcium phosphate 0.2% by weight; xylit 50.0% mass .; odorant of renta 0.5% mas .; calcium gluconate 7.0% by weight; sodium fluoride 5.0% by weight; 50 ml of aqueous extract of the cyanobacterial strain of Spirulina platensis cyanobacteria recalculated for dry matter 0.5% by mass. and root extract of Armoracia rusticana Lam recalculated for dry matter 0.05% mas. Then the table is subjected to formatting.

The chewing gum obtained represents a homogeneous white color with a pleasant taste and smell of peppermint. Pharmacological and clinical research has shown the presence of anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 8. Weigh all components according to the receipt based on the calculation for 1 kg of ready-made product. It is charged to the reactor at 70 ° C with stirring containing 20.0% by weight of the polymer base. and molasses 0.5% by mass. The mixture obtained is stirred for 5 min. Then, in the stirring mixture, 0.4% more silicon dioxide is added; dicalcium phosphate 0.05% by weight; saccharine 61.00% mas .; odorant of 0.5% duck anise; calcium gluconate 8.0% by weight; sodium fluoride 4.0% by weight; extract of Flores calendulae 0.5% more; root extract of Armoracia rusticana Lam 0.05% mas. and color dye 0,5% mass., dissolved in 50 ml of water. Then the table is subjected to formatting.

The chewing gum obtained is о homogeneous blue color with taste and pleasant smell of anise. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

Example 9. Weigh all components according to the receipt based on the calculation for 1 kg of ready product. It is charged to the reactor at 70 ° C with stirring containing 20.0% by weight of the polymer base. and molasses 0.5% by mass. The mixture obtained is stirred for 5 min. Then 0.25% more silicon dioxide is added to the stirring mixture; potassium metaphosphate 0.2% by weight; saccharin 55.0% mass .; odorant of 0.5% duck anise; calcium gluconate 8.0% by weight; 10.0% by weight of sodium fluoride; dry extract from the cyanobacterial strain of cyanobacterium Spirulina platensis recalculated for dry matter 0.05% mass .; Flores calendulae extract recalculated for dry matter 0.5% mas .; root extract of Armoracia rusticana Lam 0.05% mas. and color dye 0,5% mass., dissolved in 50 ml of water. Then the table is subjected to formatting.

The chewing gum obtained is о homogeneous blue color with a pleasant taste and smell of anise. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.

MD 3901 G2 2009.05.31

Example 10. Weigh all components according to the receipt based on the calculation for 1 kg of ready product. It is charged to the reactor at 65 ° C under continuous stirring 22.0% by weight of the polymer base. and glycerin 1.5% by weight. The mixture obtained is stirred for 4 min. Then, in the mixture with continuous stirring, 3.0% silicon dioxide is added; xylit 51.7% mass .; vanillin odorant 0.2% by weight; calcium glycerophosphate 6.0% by weight; anionite in the form of fluoride 10.0% by mass .; 50 ml of aqueous extract of the cyanobacterial strain of Spirulina platensis cyanobacteria recalculated for dry matter 0.3% by weight; Flores Calendulae extract recalculated for dry matter 0.5% mas. and 0.1% green color dye. Then the table is subjected to formatting.

The chewing gum obtained is о homogeneous green color with a pleasant taste and odor of vanillin. Pharmacological and clinical research has shown the presence of high-activity anti-inflammatory and anti-inflammatory activity in the proposed chewing gum. Allergic reactions and irritant action have not been detected.