Gastro-resistant omeprazol microgranules and process for production thereof

The invention relates to the medicine, namely to the pharmacology. Summary of the invention consists in the fact that the omeprazol microgranules comprise a neutral core consisting of sugar and starch, an active layer comprising omeprazol in combination with mannitol as well as a polymeric gastro-resistant coating, the omeprazoland mannitol ratio in the active layer being equal to 1:1. The claimed process for production of omeprazol microgranules includes mixing of omeprazol and mannitol in the presence of a colloidal polymeric binder, application of the obtained mixture on the neutral cores and the subsequent superposition of the polymeric gastro-resistant layer, after what the obtained flakes are extracted, dried and calibrated. The omeprazol and mannitol application on the neutral core is realized in a dry state by means of a polymeric binder solution of the hydroxypropylmethylcellulose type of a high viscosity in the 80% mass ethanol and 20% mass water mixture. The result consists in increasing the active layer stability. Claims: 9