Therapeutic agents

This invention includes a description for formula I<IMAGE>and their saline, useful in pharmacy; where R50 is hydrogen or Cl-4 alkyl, A51 is oxygen, sulphur or NR52 formula group; where R52 is hydrogen of C1-4 alkyl; A50 correspond to 1) mono- or bicyclic aromatic ring, which can have one or several nitrogen, oxygen or sulphur atoms, ii) cycloalkenyl group, iii) non-cyclical bridge with a one, two or three atoms chain, which is located between the cyclobutanedione group and Xso, described as a chain, this is one or two carbon atom chain, or a chain, made from one carbon atom and one or several nitrogen, oxygen and sulphur atoms or iv) connection; X 50 is a connection or interim group, connecting a chain of one or several atoms length between A50 and B50; where B50 is a mono- or bicyclic aromatic ring, which can have one or more nitrogen, oxygen or sulphur atoms, r is an integer number from 1 to 6; and Het is a ring system, which can have one or more nitrogen, oxygen and sulphur atoms or is phosphinite or amine formation (where A50, X50, B50 and Het can be substituted).The compounds include angiotensin II antagonist activation and are used for treating blood vessel disorders such as hypertension.