Saccharide absorption inhibitor and food containing same

[Detailed Description of the Invention]

(Technical field to which an invention belongs) This invention relates to the foodstuffs containing sugars absorption depressants, such as sugars absorption depressants, such as sucrose, and this sucrose, Are the special material extracted from the product of nature, safety is very high, and, moreover, the object is fructose (fructose), It is in offer of the foodstuffs containing sugars absorption depressants, such as sugars absorption depressants, such as sucrose which control the absorption in the body of sucrose (sucrose), and also suppress the neutral fat in serum, and the increase in lipid peroxide, and has an anti-overweight operation by extension, and this sucrose. (Conventional technology and its fault) Meal tendencies are sugar, rice, noodles, bread, and a potato regardless of recent years, a small child, and adult age, in connection with the general tendency which the non-fibrous-carbohydrates system food like various confectionery is increasing, there is a tendency which the amount of accumulation in body of glucose tends to increase in modern people -- a result -- surplus glucose -- as fat -- the inside of the body -- accumulating -- having -- irrespective of small-child 9 child and adult age -- an overweight-ized tendency -- increasing -- Listen . In particular, in younger age group small-child 9 child, the actualization tendency of the illness originating in the overweight and hyperlipemia based on such superfluous glucose ingestion, or this hyperlipemia becomes large, and owner Cause of an impaired liver function, diabetes, and cardiopathy and Astringent have been medically solved in this overweight in connection with it. If a juvenile child has especially, what is called an overweight child is increasing rapidly in the past ten years. In addition, if neutral fat and cholesterol increase into blood based on superfluous ingestion of such non-fibrous-carbohydrates system food, the viscosity of blood will rise and it will carry out raw [ of the phenomenon what is called of Oh blood ], In order that Surface distortion to a capillary vessel may decrease, it becomes insufficient nutrition supplying in the distribution light of a peripheral vessel, raw [ of various kinds of skin disease and various kinds of general physical complaint ] is carried out, and it is easy to produce diseases, such as hyperlipemia and arteriosclerosis nature. Although it is still unknown whether a direct cause is carried out to heavy eating and overweight of such non-fibrous-carbohydrates system food on the other hand, in a juvenile child, many allergy diseases (for example, obstacles, such as atopic dermatitis and asthma) are also seen. Although it is required to carry out a meal improvement and to change into the nature matter of low sugar so that high non-fibrous-carbohydrates foods originally may not be eaten much to control the above-mentioned inclination to grow fat especially, Food which eats such high non-fibrous-carbohydrates foods much (the fact that Junko is governed by childhood experiences throughout life serves as evil of an improvement of the above-mentioned food tendency, and the improvement of high #M Quality food heavy eating is again actually rather difficult, considering everyday experience.) The market is provided with much foodstuffs which control anti-overweight from the former in the light of such a social phenomenon. However, these foodstuffs make the main ingredients the mannose which is not absorbed in a human body, and side effects had become a problem in many cases. That is, the balance of ingestion nutrition worsened in these anti-overweight foodstuffs, the shape of nutrition deficiency was caused, and there was a fault of being easy to start the illness of other infection. Although overweight was considered on the other hand as what carries out the cause of hyperlipemia or the arteriosclerosis while it continued for years and superfluous ingestion of sugar (sucrose) caused overweight like the above, The analysis and an elucidation progress especially in recent years, hyperlipemia comes to be solved as it being a reason substance in which fructose which is the decomposed materials in the alimentary system of sucrose serves as a trigger, and absorption control of fructose has been considered to be a factor of important anti-overweight foodstuffs with absorption control of grape sugar. Therefore, the anti-overweight not only needs to control absorption of glucose in the living body, but needs to grant the absorption control ability of fructose which is decomposed materials of sucrose simultaneously. That is, it is even if the above-mentioned eating habits are not changed, namely, it takes in superfluous sucrose by taking orally, If absorption of fructose used as the absorption control of glucose and the reason substance of hyperlipemia constituting the direct cause of overweight is controlled after a digestive organ decomposes this into glucose and fructose, even if it eats a regular amount of food which has the usual sweet taste at the time of taking orally, that intake is controlled at the time of absorption in the living body -- a result -- an eating person -- what -- this artificer acquired the knowledge that pain could also cancel overweight and hyperlipemia without changing eating habits nothing. On the other hand, this artificer is although research was wholeheartedly continued about the foodstuffs which have various anti-overweight operations from before, In this research process, it found out that the black pigment ingredient extracted from non-refined sugar which is materials of the refined sugar usually used for a surprising thing, such as unrefined sugar and molasses, had glucose absorption depressant action and an antiallergic action, and already clarified it. It also solved that the black pigment ingredient extracted from non-refined sugar, such as this unrefined sugar and ti honey, in addition is a phenyl glucose compound, and it already clarified. In the process in which this research is recommended, this artificer finds out sugars absorption depressants, such as sucrose which cancels the above-mentioned conventional fault entirely, and completes the invention of the foodstuffs which use this depressant and this depressant as an essential ingredient. (Solving means) Namely, the black pigment ingredient of which this invention is extracted from non-refined sugar, such as unrefined sugar and molasses, For example, the foodstuffs containing sugars absorption depressants, such as sugars absorption depressants, such as sucrose which uses 3.4-dimethoxy phenyl 0-D-glucose and/or 3, and 4 *6-Drimethoxy 0-D-phenyl glucose as an essential ingredient, and this sucrose, are started. (EXAMPLE) What is obtained by the following method is called black pigment ingredient extracted from the non-refined sugar used in this invention, such as unrefined sugar and molasses. Preparation manufacture of the non-refined sugar, such as unrefined sugar (the so-called non-refined article of sucrose) or molasses, is usually first carried out from sugarcane or a beet. Subsequently, the pigment ingredient which washed adsorbent and removed sugar enough [ further ] and to which dissolve non-refined sugar, such as this unrefined sugar, in the water of an adequate amount, contact this to adsorbent, and the pigment ingredient was made to stick to adsorbent, and it stuck after that is Elution(ed) from adsorbent with a solvent. ' usual and this Elution operation are performed by the column chromatography method which completed adsorbent. the polystyrene system resin adsorbent of the non-polarity as adsorbent used in this case, for example, for example, Amberlite XAD-1, Amberlite XAD-2 (and [ loam, ], made in Haas), and a cell -- a tapir -- ROM YAD-2 (made in Selva) is preferred. the cell from a point of yield -- a tapir -- ROM YAD-2 is the most preferred. The rough black pigment ingredient obtained in this stage can also be used as sugars absorption depressants, such as sucrose, in this invention. That is, it may condense under decompression of outflow liquid and may use as a Flow extract, a soft extract, and a solid extract. It is 30~300 times (weight) as desirable as a content pigment ingredient, and 50~200 times are suitable for the amount of the adsorbent used. Sugar may fully be removed and a washing outflow may be carried out until in making the pigment ingredient to which it stuck Elution it washes before Elution and the sweet taste of Wash liquid is completely lost. It is preferred for Elution of a pigment ingredient to carry out by lower alcohol, for example, methanol, or ethanol of 20% or more of concentration. After 20~30% of low concentration lower alcohol performs Elution first in fact and coloring of flowing-down liquid is no longer accepted hardly, it is preferred to make it further Elution with high concentration lower alcohol which is about 95~99%. Because, if only high concentration lower alcohol performs Elution, yield of a pigment ingredient falls and it is not desirable. Thus, if refining judgment is carried out with a silica gel column after evaporating obtained Eluent to dryness, a white phenyl glucose compound will be obtained. This phenyl glucose compound is specific oligosaccharide contained in the pigment ingredient of non-refined sugar, such as unrefined sugar. Thus, the inner phenyl glucose of I got it specific oligosaccharide is contained 40% or more by a weight ratio, and especially 3 *4-dimethoxy phenyl O-D-glucose is beyond about [ of specific oligosaccharide ] inner 20%, Or 3 *4.6-Drimethoxy 0-D-phenyl glucose carries out abbreviation IOchi grade content. Although the inner operation ingredient of this black pigment ingredient is mainly specific oligosaccharide, Phenyl glucose occupies 40% or more among this pigment ingredient, and, as for 3.4in phenyl glucose-dimethoxy phenyl O -D - glucose, and 3.4.6-Drimethoxy 0-D-phenyl glucose, it occupies 15% or more. This experimental learning was performed by the quality of usual state methods, such as GLC, TLC, NMR, IR, and UV, and the quantitative analysis. In this invention, by the organic synthesis method, the ether bond of the phenyl glucose compound was carried out chemically, it may Ah a phenyl group and a glucose machine, and is not limited especially as that synthesizing method. As a functional group, as long as it requires, the phenyl glucose compound compounded with the synthesizing method to which the ether bond of C3 and C4, 3 replaced by the position of C6, 4-methoxypheny machine or 3, a 4.6-methoxypheny machine, and the glucose machine is carried out may be sufficient as a methoxyl group. The phenyl glucose compound which is the specific oligosaccharide used by this invention is denoted by a following formula. It is (formula ■) about 3.4-dimethoxy phenyl 0-D-glucose, and is 3 and 4.6. - It is trimethoxy 0-0-phenyl glucose (formula ■), and is front A. In this invention, this phenyl glucose compound may be obtained by which method of a synthetic method and a product-of-nature sampling process, and these both may be mixed. In this invention, a usual state method is followed in tJi(s) absorption depressants, such as such sucrose, Usually, addition mixture of a diluent base, an extender, a binding material, a preservative, the spice, etc. can be carried out, and it can be made the form of this kind of medicine and the form of foodstuffs, for example, a tablet, an emulsion, a capsule agent, an injection, a tablet, a granule, an energy drink, a syrup, soft drinks, etc. However, as for the effect of this invention being demonstrated most, mixing to a sweetener, i.e., sugar, is most desirable, and they are sweet taste foodstuffs using this sweetener, such as Cookie, a cake, and Japanese sweets, further. When sugars absorption depressants, such as sucrose concerning this invention, are used as a sweetener and sweet taste foodstuffs, It may blend at a rate of 5~20 to sucrose 100, and they are a tablet and an emulsion, When considering it as the form of a capsule agent, an injection, a tablet, a granule, an energy drink, a syrup, soft drinks, etc., it is 100B~5000mg (it may be considered as the combination which can carry out 50 mg~100100O grade Meal as phenyl glucose.) as a black pigment ingredient. (EFFECT OF THE INVENTION) An example and the example of an examination are indicated below. EXAMPLE Dissolve boiling sand sugar 5 kg from Okinawa in water 25j!, pour into the column of inside diameter 8 c!II which distributed water 11 and was filled up with polystyrene system resin (cell a tapir ROM X A D-2,300 g), it is made to flow down the speed for 20m l /, and the pigment ingredient of brown sugar is made to adsorb. next -- making it flow down water -- sweet taste -- all (after washing and fully losing sweet taste completely in flowing-down liquid excluding sugar until it is lost, pour in 20chi methanol, and it is made to flow down the speed for lQml/, and pigment is made to Elution from adsorbent) Zero-car flowing-down Eluent which continues flowing down is together put until coloring completely becomes flowing-down liquid, decompression evaporation to dryness is carried out below by 60 degreeC, and brown residue 16g is obtained. This thing is heated and melted in the pure ethanol of 21, the depositing muddiness substance is filtered after cooling, decompression evaporation to dryness is carried out below by 60 degreeC, that residue is dried below by 60 degreeC, and brown powder 15g of sweet taste which is not is obtained. Rf value of the following thin layer chromatography and the absorption value of an infrared absorption spectrum to phenyl glucose of the obtained brown powder was an operation ingredient. Thin layer chromatography; 10 mg is dissolved in 1 ml of water, and according to the following conditions, when examining by the 26th paragraph thin-layer-chromatograph method of Japanese pharmacopoeia General Test Procedures, a single red spot is shown in Rf value 0.6 [ about ]. The amount of sample attachment: 10microl Carrier Veggie gel 60F254 Developing solvent (thickness 0.25 a+m by Merck Co.) : Chloroform methanol and water (65:35:10) lower layer Deployment distance : 10 cm detection :P after [ - anisic aldehyde test solution spraying ] and 105 degreeC -- for 5 minutes -- Heating -- the spot was the same spot as the mixture of 3.4-methoxypheny glucose, 3, and 4.6-methoxypheny glucose. Infrared resonance spectrum; numax (nujol) : 3300.1590.1020 and 720CI11-1 It is shown that this infrared resonance spectrum is the phenyl glucose replaced by Methoxyl. The identification method of this substance carries out the after-mentioned detailed explanation. The obtained brown powder was dissolved in 500 cc methanol, column chromatography refining was carried out with the silica gel column using the flowing-down solution of chloroform methanol and water temperature liquid, and it classified to 3 and 4-methoxypheny glucose and 3.4.6-methoxypheny glucose. The next examination was done using this white crystal and above-mentioned brown powder. Example 1 of an examination Using six groups of the Wister system Male and a throat (OFF object N80g and one groups [ 5~6 ]), it made an incision in the abdomen under Nep tar anesthesia, and used about 15 cm of Jejunum portions for the experiment. After cutting the upper end and lower end of a small intestine to be used and probing Lumen by a Talebu Sous Ringer's solution phosphate buffer (pH 7, 4), the upper end and lower end of the small intestine were connected by the silicon tube (1.0 mm in inside diameter), and flowing-back liquid 20m1 was circulated by 2 * A 1/min. This flowing-back liquid uses what added 1000 microhenries of glucose to Talebu Sous Ringer's solution phosphate Buffa (pH 7, 4) liquid about contrast group 1, Contrast group 3 added glucose 1000microhenry and fructose 1000muh using that by which contrast group 2 added 1000 microhenries of fructose to Talebu Sous Ringer's solution phosphate Banchha (pH 7, 4) liquid. As for 3 of an examination group groups, examination group 1 is 20micro The gate added about 3.4-methoxypheny glucose to the flowing-back liquid of contrast group 3, respectively, Examination group 2 used that by which examination group 3 50micro of brown ingredient h Added what 20microi Added 3.4.6-methoxypheny glucose to the flowing-back liquid of contrast group 3 to the flowing-back liquid of contrast group 3, respectively. From immediately after the flowing-back start, a little flowing-back liquid was extracted over 20 minutes every 5 minutes, and the concentration of glucose and fructose was measured. In the bottom, the result of glucose (GL unit is I1 g/dl) and fructose (PL unit is mg/dl) is shown in the 1st table and the 2nd table in fixed quantity. 1st Table Example of IGLIO part 15-minute examinations [ 110 minute / 115 minute / 120 minute / 11 ] (1) 110001 9951 9901980 1 Example of 98011 examinations (2) 11000199319861982 1 Example of 97011 examinations (3) I 1000199019841966 1 95711 Contrast Group (1) 1100018501820180017 8011 Contrast Group (2N Ol 01 01 01 011 Contrast Group (3) 1100018201810180117 621 The 2 Table) Example 110001 of IFLIO part 15-minute examinations [ 110 minute / 115 minute / 120 minute / 11 ] (example 12 of 1111000199719911988 196511 examination) 99019861980 1 Example+31110001 of 97511 examinations 9911 9851964 L 95911 Contrast Group (Ill) Ol 7881 <--1 contrast group 01 (to 100 or more women [ 20 ] (from 18 years old to 55 years old), example of 3111000182618151811 17671 examination 2 corpulence degree is) 0fOf Of1 contrast group (2) +10001 8561 8231 8011 The sweetener used with everyday eating habits was changed into what consists of the following composition, and change of the corpulence degree of four months after was seen. It was not made to eat entirely, but private manufacture was carried out using the sweetener using the sugar containing sugars absorption depressants, such as sucrose used in this example of an examination, and the between-meal snack of commercial Cookie, a cake, a candy, etc. made only the between-meal snack of that private manufacture eat. Only -- the amount of Meal was not limited but the quantity which the person himself/herself wants was made to eat . The reduction rate of a corpulence degree is shown in the 3rd table. Composition Sucrose 85 chi Black coloring component 15 chi Sum total 1001 3rd Table 1 Early stages of one 14 months after 11100~115 1 0 (person) 1 5(person)11115~13011 1811130~14516 1311145~16018 1311160 or more +5 It turns out that the foodstuffs containing sugars absorption depressants, such as sugars absorption depressants, such as sucrose concerning this invention, and this sucrose, have the effect excellent in the absorption depressant action of sugars, such as sucrose, so that clearly from the result more than Il+.