Treatment to make plastic capillary tube hydrophilic

[Detailed Description of the Invention]

The present invention relates to the new hydrophilicity-ized disposal method of hydrophobic polymer or the capillary tube made from a plastic which groans. It is Disease source1' to inspecting engineers [ in / a hospital etc. / although the thing made from inorganic glass is conventionally used as a medical inspection bristle small tube, it is easy to damage this kind of capillary tube, and it has a practical fault of being unable to perform incineration disposal of used elegance, and ]! It also becomes a cause in which A carries out secondary infection, and has been a big problem. For this reason, use of the capillary tube made from a plastic is demanded. It is publicly known by carrying out fusion Chinese poem type of the hydrophobic polymer excellent in transparency, such as poly (meta) acrylic ester and polycarbonate, to manufacture a capillary tube. However, to especially hydrophilicity-ize the inside of a capillary tube is tried by a medical bristle small tube's needing to be hydrophilicity, and kneading a surface-active agent to hydrophobic polymer, and carrying out fusion Chinese poem type to it, or processing the capillary tube surface with a surface-active agent. however, this - if based on the method [ like ], permanent hydrophilic performance is not got, but the hydrophilicity-ized capillary tube is demanded, but the present condition is that what can be used has not been developed yet. In order to hydrophilicity-ize permanently the capillary tube which consists of hydrophobic polymer, as a result of examining many things, by introducing a hydrophilic group into polymer by a specific method, these artificers achieved the object and found out scales. The present invention is a hydrophilicity-ized disposal method of the plastic character capillary tube processing the capillary tube which consists of hydrophobic polymer using fluoride gas, sulfurous acid gas, and the mixed gas of inactive gas. As for the capillary tube with which processing of the present invention is presented, what generally has an inside diameter of 0*5~2.0 dragon and an outside diameter of 0.7~2.2 dragon is desirable. The smooth thing of the surface is desirable. To polycarbonate, polyester, polystyrene, etc. are suitable for J nature which spaces a capillary tube preferably. In such a capillary tube, if fluoride and sulfurous acid gas are processed using the inactive gas to contain by the present invention, while some hydrogen atoms of polymer are replaced by the fluoride atom, a sulfo fluoride machine (- S02F) and a sulfonic group (- SO3H) will be introduced into polymer. For example, a following formula can show the reaction in the case of using poly methyl methacrylate (PMMA). CF. CH. The right-hand side of this equation (1) - (-CI, -C/, Co2CH.) In Poke, people do not mean that it is and show stoichiometrically a polymer chain. Although a reaction advances according to a formula (1) in polymethyl methacrylate, in the case of polycarbonate, polyester, and polystyrene, generally a molecule chain end or a main chain is cut, and basis-5o2p', -8o, and H are introduced. it is required to combine basis-8o2F, -8o, and H in an adequate amount in polymer for hydrophilicity-izing -- the coupling amount -- general -- more than 2 mol %, preferably more than 4 mol % -- it is more than 5 mol % especially. It is intricately dependent on F' in contact mixed gas, the concentration of S02, a gas mass flow, reaction time, reaction temperature, etc., and can control the coupling amount of basis-8o, F, -8O, and H by changing these. As a result of Inspection(ing) various these conditions, it was known by hydrophilicity-ization by keeping the capacity ratio of S 02-pair inactive gas versus F2 in mixed gas at 0.1~10/10~50/40~89.9 that introduction of A] Effective group-8o2F, -8o, and H is possible. The mixed gas of 0.1~5 capacity % has preferred fluoride gas concentration. As inactive gas, rare gas elements, such as nitrogen, a helium, neon, and argon, or the mixture of those can be used. Although it is dependent on reaction temperature, catalytic reaction time is selectable as together joined in sufficient basis-8o2F for hydrophilicity-izing, and -003H, and, generally is 60 seconds or more, preferably 60 seconds or more. As for reaction temperature, near room temperature is preferred. united basis-8o2F, -3o, and H can be checked with a Fourier transform infrared absorption spectrum -- the fixed quantity -- acid-alkali titration -- Plaster # To do with ice -- things are made. being able to use an ordinary device, in order to enforce the present invention method, for example, mixing fluoride gas, sulfurous acid gas, and inactive gas in a gas mixture machine first, and introducing this mixed gas into the reaction machine into which the capillary tube was put -- ?r -- better -- There. Absorption processing of the gas discharged is carried out by a usual state method. Basis-8o and F which were combined with polymer can be rich in reactivity, can be easily changed into a hydrophilic group by a publicly known method, and can further improve hydrophilic performance. Typical methods are hydrolysis and Addition alcoholysis. a mixed gas reaction product is only immersed in water -- excel and basis-8o 2F are hydrolyzed -- basis-8O3■ (since it changes, a hydrolysis method is preferred.) According to the present invention, an easy means can give eternal hydrophilic performance to a hydrophobic capillary tube, since it is phase inversion treatment, there is no necessity for complicated back processes, such as a flush and dryness, and also as for reaction Residual and Remaining, 1 is good. Therefore, especially the hydrophilic capillary tube obtained by the present invention method is suitable for medical science as a my Clopi petter. % in the following example is capacity %. Example 1 Hydrophilicity-ized processing is performed using the device shown in a drawing. The capillary tube (inside diameter Q, 7 mm, outside diameter 1.0 order, length 1nt) manufactured from polymethyl methacrylate is cut to the length of 10Crn, and it takes to the sample omega implement second in reaction machine 2, and is To ask. Subsequently, after opening valve v-1, ■-2, and V-3 and making almost completely the inside of gas mixture machine 1 and reaction machine 2 into a vacuum with vacuum pump 5, valve V-2 and V= 3 are closed. Then, valve V-C of sulfurous acid gas cylinder B-1 is opened, and V'-C is closed, after introducing sulfurous acid gas in gas mixture machine 1 until the pressure of pressure gauge G-1 is set to 0.89 ky / cm2abs, a fluoride gas cylinder (10%Ii'27 N2) -- opening valve V-B of B-2 (V-delta is closed, after N2 introduces 2 until it closes V-B, and also it opens valve V-A of nitrogen gas cylinder B-1 and the pressure of G-1 is set to 2 ky/crn2abS, after introducing F2 gas diluted with nitrogen gas until the pressure of 3-1 is set to 0.99 kg / on2abs.) If it is neglected for a predetermined period, a gas mixture machine content will be uniformed, and it is Depends on to composition of 44.5% of sulfurous-acid-gas, and fluoride gas 0.5%, and 55% of nitrogen gas. After homogeneous mixed gas generates, valve ■-2 is opened, this mixed gas is introduced in reaction machine 2, the pressure of pressure tlG 2 is made into 1 kg/cIrL2abs, and this pressure is kept for 200 seconds. In this way, after performing PMM 8 capillary capillary tube Tactile reaction at room temperature, valve V-3 is opened and the mixed gas in reaction machine 2 is discharged through hydrogen fluoride absorber 6 and fluoride absorber 4 with vacuum pump 5. After opening valve V-4 and returning reaction machine 2 to normal pressure, a PMMA capillary tube is taken out. The capillary tube picked out from the reaction machine is 10 (it has the absorption based on -NII 2 in][l~1250CrrL-, and, thereby, introduction of the polar group was checked at the absorption based on -8o2F, -8o, and H, and 3300~3400 cTL'.) by a Fourier transform infrared absorption spectrum. Basis-8o2F is changed into basis-3o and H by immersing this capillary tube in the water of room temperature for 1 hour. Hydrophilic evaluation is Si [(straight hair superintendent priest 1 (carried out by 9 * and inclination hair 'IS length H45.)). I -- " -- 190 -- " -- ' -- the water surface -- receiving -- perpendicular -- a capillary tube -- contacting -- having made -- the time -- a pipe -- an inland sea -- a pillar -- high -- a fence -- mm -- H -- 45 - the water surface -- receiving -- 45 -- degree -- an angle -- a capillary tube -- contacting -- having made -- the time -- a pipe -- inside -- a column of water -- high -- a fence -- mm -- hydrophilicity ---izing -- having processed -- l -- ' -- one -- MMA -- a capillary tube -- one --] -- o -- 16 -- mm -- ■ -- two . -- 66 -- Dismissal -- it was . An unsettled capillary tube is 11. But 9~11J mm and 11 A, are 18~2omrl. Example 2 It is operated like Example 1, however catalytic reaction time is made into 80 seconds, operation of the vacuum exhaust air-Mixed gas supply ON of a reaction machine is repeated 6 times, and it is made to react for Grinding 240 seconds. H9 * of this P M M A capillary tube was 18 mm, and H45 was 40 dragons. It is accepted by Inquiry(ing) ventilation operation that hydrophilicity-ization is promoted. Example 6 By changing pressure conditions, mixed gas concentration is changed, and the contact time per time is changed, and hydrophilicity-ized processing is performed like Example 2. The obtained result is shown in the following table. It is accepted that the optimal value exists in the rate of a fluoride gas part and catalytic reaction time in mixed gas. Example 4 On experiment 20 conditions in the example second, if the capillary tube made from polycarbonate (0.7 mm in inside diameter, and outside diameter 0.9 mm 170 mm in length) is hydrophilicity-ization-processed, the hydrophilic capillary tube whose Hoo(s) are 20 dragons and whose H45 is 45 mm will be obtained. As for an unsettled capillary tube, J"go(es) are 9~10 mm and ■ (5 is 18~20 throat.). Example 5 It is inside diameter 0.8+nm by the copolymer which consists of methyl methacrylate (60wt%) and [1-butyl Acrylate-1- (40wt%) to fusion fabrication, The capillary tube of outside diameters 1 and 2B and length 1 m is manufactured, this is cut to the length of 10c11z, and the hydrophilic capillary tube of 69~45 Remuneration is obtained [ hydrophilicity-ized processing Soult and Hur+ ] for 19~22 tra and H45 on the same conditions as Example 1. An unsettled capillary tube is Ho. But 8~9 mm and mountain , are 18~20 Tomorrow.

[Brief Description of the Drawings]

A drawing is a flowchart for which the embodiment of the present invention method is shown, and, as for a hydrogen fluoride gas absorption machine and 4, a gas mixture machine and 2 are [ a vacuum pump and 6 ] sample fi3 implements a fluoride gas absorption machine and 5 a reaction machine and 6 1. Applicant Mitsubishi Rayon Co., Ltd. Representative Patent attorney smallness Wood Masao