Syringe for injecting metered quantities of various liquid therapeutic agents.

[Detailed Description of the Invention]

The injector present invention which pours in a fixed quantity of fluid curative medicines of a different kind relates to the fluid curative medicine of a different kind, especially the injector which carries out capacity pouring of the insulin. Such an injector is an insulin injector of Hoequest ()IOEcH5T currently sold by name "Obtipen (OptiPen) (registered trademark) J, for example. Other injectors are sold by NORDISK (NORDISK) by the name "in A project X (Insuject-X)" (registered trademark). being manufactured by Novo (NOBO) Indus Trease otherwise finally -- "Novo Ben I (NovoPen I)" (registered trademark) and the "Novo Ben old NovoP There are two injectors currently sold by en II (registered trademark)." All of these injectors can be prescribed [ of the measured insulin ] for the patient. These can prescribe an ordinary kind of insulin for the patient substantially. These injectors have one kind of insulin, for example, a standard insulin, and the fault that only one kind in an insulin or a mixed insulin can only be injected for a long time, for every injection. The object of the present invention aims at providing the injector of the type which can prescribe for the patient the insulin of a kind which was stated to especially the top which can inject several sorts of fluid curative medicines by the element mixture ratio arbitrarily chosen that it is simultaneous or continuously by injection of - time, and was described. here -- a substance, i.e., a curative medicine, especially an insulin -- immediately (after being mixed within the container separated, namely, distinguished and stored especially) -- or it is not important whether time is placed and a medicine is prescribed for the patient. According to the present invention, the object is attained by the composition of the range l of a claim. Invention improvement and an advantageous embodiment are acquired from the range of a subordinate claim. Other features, details, an advantage, and application will become clear from explanation and the accompanying drawing of the desirable example of the following present invention. having the hypodermic needle device which was open for free passage in two containers which Drawing 1 includes an injection housing with the needle main part attached to the end, are arranged in the curative medicine container interior of a room, and store a fluid curative medicine -- calculation -- it is a sectional view of the length direction of the injector by the present invention which also has - measuring means and an injector uncoupling device. Drawing 2 is a sectional view which met the ■-■ line of the injector of Drawing 1. Drawing 3 is a sectional view which met the ■-■ line of the injector of Drawing 1. Drawing 4 is a sectional view of the curative medicine container room where it has two independent rooms mutually separated by the partition, and each of it has the separated curative medicine container (cartridge) whose section is a hemisphere form. Drawing 5 is a sectional view of the single part curative medicine container room where each section has two separate curative medicine containers which are semi-circles. Drawing 6 is an enlarged drawing of the hypodermic needle device in the 2nd example of the injector of the present invention connected to three containers which store a curative medicine which is arranged at the triangle which adjoined spatially, namely, made the same distance mutually, and is different, respectively. Drawing 7 is a sectional view of a curative medicine container room which has three separate A room by which the separate curative medicine container (cartridge) in which a partition dissociates and a section has the shape which is a circle for 3 minutes is arranged respectively (it corresponded to the injector of the 2nd example of Drawing 6). Drawing 8 is a sectional view of a single part curative medicine container room which has three separate curative medicine rooms where each section has the shape which is a circle for 3 minutes (it corresponded to the injector of the 2nd example of Drawing 6). Drawing 9 is an enlarged drawing of the hypodermic needle device in the 3rd example of the injector of the present invention connected to four containers which store a curative medicine which is arranged at the square which adjoined spatially, namely, made the same distance mutually, and is different, respectively. Drawing 10 is a sectional view of a curative medicine container room which has four separate A room by which the separate curative medicine container (cartridge) in which a partition dissociates and a section has the shape of a quadrant is arranged respectively (it corresponded to the injector of the 3rd example of Drawing 9). Drawing 11 is a sectional view of a single part curative medicine container room which has four separate curative medicine rooms where each section has the shape of a quadrant (it corresponded to the injector of the 3rd example of Drawing 9). Drawing 12 is a schematic diagram of other examples which fix a needle main part to a container housing with a lock device, and is Drawing 13, It is a schematic diagram of other examples which fix a needle main part to a container housing with a spring clip apparatus (the method of the lid of beer A bottle), and is Drawing 14, It is a schematic diagram of other examples which fix a needle main part to a container housing with a spring ring device, and is Drawing 15, It is a schematic diagram of the fluid / curative medicine container in which re-restoration is possible, and is Drawing 16, It is a schematic diagram of the piston of the fluid / curative medicine container in which re-restoration of Drawing 15 is possible, and is Drawing 17, In order to interrupt supply of a fluid, it is a schematic diagram of the front part of the injector provided with the needle main part which can move along the length directional-axis line (in open position), and Drawing 18 is a schematic diagram showing the front part of an injector according to Drawing 17 (in closed position), Drawing 19 is a schematic diagram of the front part of the injection device provided with the needle main part which can rotate freely focusing on a length directional-axis line in order to interrupt supply of a fluid (in open position), and it is Drawing 20, In order to interrupt supply of a fluid (in open position), it is a schematic diagram of the front part of the injector provided with the closing main part which can be inserted in the direction of arrow X by addition into a hypodermic needle from the backside of the needle main part which can rotate freely focusing on a length directional-axis line, and an injector. Hypodermic needle device 5 which injector l of the present invention was attached to end 3 of this injector, and is arranged in needle main part 4 as shown in Drawing 1, Cup-like container housing 6 which has two curative medicine container rooms (Karr Tori, Tsuji room) 7.8 for Acceptance to put in container (cartridge) 9 containing a fluid curative medicine, and IO, respectively, two calculation which has been arranged in housing element 11 and supported by this -- having - measuring means -- these calculation - measuring means has release means 14.15 in other end 16 of injector l, respectively. Needle main part 4 preferably made with plastic material etc. comprises member 2 of a cylindrical shape completely substantially. Hypodermic needle device 5 is laid under the member 2 so that needle point 18 may project by one end of front shoulder surface 26 and two supply channels 19.2o may project from needle main part 4 by the other end of back shoulder surface 27. Annular extension 21 prolonged in the direction of an axis is provided in the side which supply channel 19.2o projects at member 2. Two slots 22.23 which extended in the direction of an axis, and preferably faced the diametral direction, and are arranged are formed in the inside of extension 21. Adjustment spring 24.25 is inserted in each of these slots. As for adjustment spring 24.25, it is good that they are extension 21 and one, and it is good to be formed as a member corresponded and projected. Container housing 6 has container bottom 28 which has external surface 29 located ahead [ direction of axis ], and inside 30 located in the direction back of an axis. Container bottom 28 has two holes 36.37 prolonged in the direction of an axis through the container bottom 28. container bottom 28 -- Hub -- it is annular and has cylindrical shape-like container wall 31 with the stage. it extends in a longitudinal direction and is arranged in the diametral direction -- preferably two slots 34.35 are formed in external surface 33 of portion 32 with the 1st step of container wall 31. This portion 32 with the 1st step exists immediately near the container bottom 28. Male screw 40 is formed in external surface 38 of the following portion 39 with the 2nd step. As for external surface 41 of the following portion 42 with the 3rd step, in order to improve treatment of injector l, being formed as the surface with a notch is preferred. Male screw 45 is formed in external surface 43 of the following portion 44 with the 4th step. finally, it extends in a longitudinal direction and is arranged preferably in the diametral direction -- preferably two slots 48.49 are formed in external surface 46 of portion 47 with the 5th step next to container wall 31. in the inside, container housing 6 is prolonged from container bottom 28, and it is preferably separated mutually by partition 50 -- preferably it has two curative medicine container rooms (cartridge room) 7.8. in the inside, container housing 6 is prolonged from container bottom 28, and it is mutually separated alternatively by partition 50 -- preferably it has two or more curative medicine container rooms (cartridge room) 7.8. Housing element 11 makes a Hub cup-like form, and has housing bottom 51 provided with the direction external surface 52 of an axis of a housing bottom, and the direction inside 53 of an axis of a housing bottom again. In front field 54 of side wall 55 of housing element II, the inside 56 forms two fi5? and 58 preferably, this slot 57.58 is preferably arranged in a diametral direction while having extended in the longitudinal direction, and adjustment spring 59.60 is arranged respectively there. Also as for adjustment spring 59.60, it is good that they are housing element 11 and one. Housing bottom 5I has two holes 61 and 62 which penetrate the above-mentioned housing bottom in the direction of an axis. calculation -- it is preferred to be attached to a housing interior preferably [ that - measuring means 12.13 is arranged inside housing element 11 ], enabling free removal. calculation -- it is preferred that - measuring means 12.13 is fixed to inside 53 of the housing bottom of housing element 11. As for uncoupling device 14.15, it is preferred that it is piston rod 65.66, and this piston rod 65.66 equips the end, i.e., the outside, with operation knob 63.64 while being prolonged in the direction of an axis. piston rod 65.66 is calculation - measuring means 12.13 is connected with in operation. The other end, i.e., an inner side, is equipped with pressure pad 67.68. Other members of injector 1 of the present invention are curative medicine containers 80 of pre-fixed cap 91, post-fixed cap 71 and - Pieces, or some. Pre-fixed cap 91 is a cup-like main part provided with bottom wall 95 with bottom inside 94, and tubular transverse member 96. Tubular transverse member 96 equips the front field of the inside with female screw 92. Bottom wall 95 of fixed cap 91 is provided with main hole 97. Post-fixed cap 71 is a cup-like main part provided with bottom wall 75 with bottom inside 74, and tubular transverse member 76. Tubular transverse member 76 equips the front field of the inside with female screw 72. Bottom wall 75 of fixed cap 7I is provided with main hole 77. transverse member 76 and/or bottom wall 75 of fixed cap 71 -- at least one -- it removed and has - operation opening 78. Commercial curative medicine container 80 comprises the member of the shape of a Hub pipe with opening 81.82. Opening 81 which faced supply channel 19.20 pierces filled curative medicine container 80, it is closed by possible film 87, and opening 82 which faced pressure pad 67 of uncoupling device I4 is closed at the seal which can move in the inside of a tubular member, especially piston 83. the [ Drawing 4, Drawing 5, Drawing 7, Drawing 8 and ] -- as shown inO [ 1 ] figure and Drawing 11, the curative medicine container used with injector 1 of the present invention does not necessarily need to have a circle section, and, according to the present invention, the section-shaped of other section shape, for example, a semicircle, a 3-minute circle, or a quadrant may be sufficient as it. In the container of such shape, container room 9 and space which should be established in lO at injector 1 can be made small to the curative medicine container which should be stored. As a result, the whole (length and diameter) size of injector l of the present invention can be made small, and this improves the storability of the above-mentioned injector, and handling nature. the calculation of a different curative medicine which put the present invention into different curative medicine container 9.10 again - measurement medication -- single calculation -- it has intention of designing an injector so that it can carry out using - metering device. calculation -- it is also the object of the present invention to use an electric servo motor instead of the spring for controlling - metering device and driving or a spring motor. These servo motors are controlled by a microprocessor with a fixed program or a rewritable program. In order that dealing with technical equipment suitably at least may medicate the injectors which a difficult patient (especially a young man and an old patient) uses with the curative medicine of the quantity measured suitably, adopting overly small electronic art is recommended. In the injector of this form, "calculation" is performed by the microcomputer and "measurement" is performed by the electric servo motor. The internal-organs type storage battery charged via an electric power unit with the terminal of a solar cell or all form secures supply of required electric power. Next, the assembly of injector l of the present invention is explained. (1) It "is loaded" with container housing 6 with two curative medicine containers 9.10 first. If it puts in another way, two containers 9.10 will slide in container room 7.8 of container housing 6 in path of insertion E until container 9 and the front tip of lO contact inside 30 of container bottom 28. (2) Housing element 11 is substantially attached to portion 47 with the stage of container wall 31 of container housing 6. Adjustment spring 59.60 is allocated by portion 54 of side wall 55 of housing element 11, and is inserted in slot 48.49 formed in portion 47 with the stage of container wall 31 of container housing 6. In this way, to container housing 6, housing element 11 is fixed so that relative rotation may not be carried out. Simultaneously, two pressure pads 67.68 of piston rod 65.66 are arranged correctly at the front of opening 81.82 and lid 83.84 which can be displaced related to two curative medicine containers 9.10, and are arranged there. (3) Here, post-fixed cap 71 slides on housing element 11 until male screw 45 of portion 44 with the 4th step of container housing 6 engages with female screw 72 of post-fixed cap 71. If post-fixed cap 71 is rotated, bottom external surface 52 will be pushed in the direction of arrow E until the bottom inside 74 pushes bottom external surface 52 of housing element 11 and the front tip of housing element 11 contacts the trailing edge of portion 44 with the 4th step of container housing 6. Housing element 11 is fixed in the direction of an axis to container housing 6 by this. (4) Since needle main part 4 is arranged in container housing 6 and it fixes to this, Adjustment spring 24.25 which slid on annular extension 21 of needle main part 4 in the direction of an axis at portion 32 with the 1st step of container housing 6, and was allocated in extension 21 by this, or was formed in this is engaged to slot 34.35 formed in portion 32 with the 1st step. Adjustment spring 24.25 of needle main part 4, and slots 34 and 35 of container housing 6, At the front of hole 36.37 where supply channel 19.20 of hypodermic needle device 5 was formed in container bottom 28 of container housing 6, and it is allocated in [ of hole 36.37 / opening 85.86 and there ] where it is arranged immediately back, and related to curative medicine container 9 and lO -- it aligns, and it is arranged or is positioned so that it may thrust and may be correctly stood still at the front of possible film 87.88. (5) Pre-fixed cap 91 slides on needle main part 4 top, and the female screw 92 engages with male screw 40 of container housing 6. if fixed cap 91 is turned, the bottom inside 94 pushes front shoulder surface 26 of needle main part 4, and needle main part 4 will be boiled, it will push on a direction, and the back end of needle main part 4 will contact the front end of 2nd portion 39 with the stage of container housing 6. Thereby, needle main part 4 is fixed in the direction of an axis to container housing 6. (6) Finally, protection cap 99 projects from pre-fixed cap 91, and it is . It slides on Needle 18 top. Thereby, a user does not do any injuries and a hypodermic needle is protected. (7) Injector l is a reverse order and is usually disassembled for cleaning, maintenance, or re-restoration. Of course, only pre-fixed cap 91 may be removed and only needle main part 4 may be removed for exchange. on the other hand -- opening only the rear of injector 1 wide, in leaving needle main part 4 to injector l -- for example, container 9.10 of a curative medicine -- on the other hand -- or -- exchanging both -- or calculation - measuring means 12.13 may be adjusted or fixed. The 4.5.7.8.10th and 11 figures are front views of the container 9.10 grade of a curative medicine. These containers do not necessarily need to be provided with a round section, and may be provided with the section of other sections especially a semicircle, a 3-minute circle, or a quadrant so that clearly from a figure. Container 9, IO, etc. may be united with the tank which a separate container may be sufficient as or was manufactured in one. This tank comprises a plurality of special containers which have a section of the shape of a semicircle, a 3-minute circle, or a quadrant. These containers store a curative medicine which is the same or different, and an especially different insulin. about the right curative medicine container which guarantees a desired medicine, it is calculation -- the front of - measuring means 12.13 grade has a problem that it must arrange, respectively. this gives the special section which guarantees fixed arrangement within a container housing to a container -- or it is attained by giving mark 100 (refer to the 5th figure) corresponding to each mark provided in the container housing to a container. As a result, it becomes possible to position a container in a specific position, i.e., a desired position. In the desirable embodiment of the present invention, re-restoration is possible for the container of a fluid/curative medicine. In Drawing 15.16, valve gear 89 for re-restoration is provided in the curative medicine container. A room 90 with which sterilization medicine was filled for sterilization and re-use -- the front of piston 83 -- and/or, it is provided in the back and closed at a piston. Sterilization medicine carries out humidity of the wall of the container of a curative medicine between restoration processes. Piston 83 the very thing is constituted so that sterilization medicine may be stored and/or it may have A room 90 of sterilization medical use. A blood sugar measuring device may be structurally packed into an insulin injector. It is good to use the microprocessor which has here a control unit for measurement of a required display element and a given dose, the medicine prescribed for the patient, and/or piston movement magnitude for a blood sugar measuring device. Both the measured blood sugar level and the amount of insulins prescribed for the patient are needed with the time corresponding to these, and/or they can transmit. Namely, both the measured blood sugar level and the amount of insulins prescribed for the patient are observation/display window of injection / blood sugar measuring device, and they are PC/AT. That is, it can transmit to a terminal from / (a bidirectional data-communications measuring device-PC/AT and PC/AT-measuring device is possible). Took the necessity for a patient into consideration, and insulin injection / blood sugar measuring device is /. Or the program which had and corrected the medicine calculation program which directs the given dose corrected to the patient is a PC/AT terminal, it can be put into insulin injection / blood sugar measuring device, and /movement of it can be done at any time. In order to avoid the diffusion between containers 9.10, and evaporation of a fluid, the needle which can interrupt a free passage with the closing appliance which can be adjusted (main part), i.e., the closing appliance which can be displaced, (main part), and supply channel 19.20 and hypodermic needle 18 and which attaches itself must be formed in needle main part 4. Drawings 17 and 18 show the desirable example of the present invention. (It can be made to operate with spring 113) Along with longitudinal direction Axis line of an injector, in the direction of arrow X-Y of housing 129, needle main part 112 is arranged, enabling free displacement, and is supported. Supply of the liquid from supply channel 119.120 to hypodermic needle 118 can be interrupted by the main part formed in needle main part 112, preferably needle 111 itself. Another desirable example of the present invention is shown in Drawing 19. This example is related with needle (it can be made to operate with spring) main part 114 arranged focusing on longitudinal direction Axis line of an injector enabling free rotation. Supply of the liquid from supply channel 119.120 to hypodermic needle 118 can be interrupted with passage device 115 formed in housing 116 which stores needle main part 114 and this needle main part 114. It is good to rotate needle main part 114 with the closing cap (not shown) which protects the needle point of an injector. in another desirable example of the present invention shown in Drawing 20, needle (it can be made to operate with spring) main part 117 meets longitudinal direction Axis line of an injector -- it is displacement to the direction of arrow X-Y -- a crest -- it is arranged focusing on longitudinal direction Axis line of an injector, enabling free rotation. Supply of the liquid from supply channel 119.120 to hypodermic needle 118 is barred here by passage device 122 formed in housing 123 which stores main part 121 formed in needle main part 117, and needle main part 117 and this needle main part 117. A closing appliance, i.e., main part 121, is operated from the backside of an injector to needle point 118. In Drawings 17 and 18, the front side of an injector can operate a closing appliance or main part 111 from needle point 118. Suitably, needle main part 112 is being fixed to spring board 124 currently supported with shoulder 125 of housing member 126. Housing member 126 is being firmly fixed to housing element 127. (Pressure) Spring 113 is pinched between housing member 126 and housing element 127. Spring 113 has pushed spring board 124 against shoulder 125 in the direction of arrow X. As shown in Drawing 18, with closing cap 128, needle main part 112 can resist the power of spring 113, and can be moved in the direction of arrow Y. When the above-mentioned cap is screwed in housing 129 of an injector, a cap is needle main part ] to the direction of arrow Y.

12 -- forcing To be. The end of main part 111 which is supported by injection device 130 and arranged near the supply channel 119.120 closes two supply channels 119.120. Hypodermic needle 118 of injection device 130 is in the state of 131 thrust into needle main part 112 by the way suitably, as shown in Drawings 18 and 19, and it is removably attached to needle main part 112. The closing appliance or closing main part which closes supply channel 119.120 in the unactuated position of an injector may be directly attached to closing cap 128. Since a closing appliance or a closing main part is very thin, when the injector is not closed suitably, there is a possibility of bending or damaging. Closing appliance 111112 may be designed to make it operate from the side of the length direction of an injector. Advantageously, closing appliance 111112 can be inserted in injection channel 132 in the place of the mouth of supply channel 119.120, as shown in Drawings 17, 18, and 20. The injection closed position where a fluid is mixed and an airtight seal is guaranteed can be obtained with the closing appliance which can adjust or can move. For example, the injector which was used within the pocket of the best, a coat, or a shirt for a long time and with which the body was equipped is heated, and there is a possibility that water or other solvents may evaporate from a fluid curative medicine. This makes the concentration of a curative medicine increase. Then, a patient is medicated with a medicine at too high concentration harmful to a patient's health. Above-mentioned measurement prevents a possibility that a different curative medicine before this evil and medication may be mixed accidentally. Elegance -- Saw: It is S' and is HJl-Lh. Eye a - p ""': (-1 * La) Sue, A little A) * 1 - Ya! 1 Avoid i 101 - IEI -- The 1 ground ; Potato 9degree->2 Rat-' g gamma 0 - < -- Y; -! Prediction/8 International search report Eleven 111 snipe 1-k PCT/DE 90100513 international search report; Koni"mZ=?;=°;;=11sawe * 100 T-The@w-+-axis -- Mishere 11 Golf - One Bite-network 1 --- Threat --- --11 music sail