Multi-layered tubing
14 claims: 14 independent, 0 dependent
- 1内層、外層及び中間層を有する管であって、 内層は、ポリエチレンの90重量%以上からなり、 外層は、芳香族または脂肪族ポリエーテル系ポリウレタンの90重量%以上からなり、 中間層は、エチレンエチルアクリレート共重合体の90重量%以上からなる 、管。
- 2請求項 1 記載の管において、 ポリエチレンは、低密度ポリエチレン、線状低密度ポリエチレン及び高密度ポリエチレンの一つ以上からなり、 芳香族ポリエーテル系ポリウレタンは、ポリテトラメチレングリコール系ポリウレタンからなり、 エチレンエチルアクリレート共重合体は、重量で少なくとも19.5%のエチルアクリレート含量を含む、管。
- 3内層、外層及び中間層を有する管であって、 内層は、低密度ポリエチレン(LDPE)の 90 重量%以上からなり、 外層は、ポリテトラメチレングリコール系ポリウレタンの 90 重量%以上からなり、 中間層は、無水物グラフト結合されたエチレンアクリル酸メチル共重合体の 90 重量%以上からな る 、管。
- 4請求項 1~3のいずれかに 記載の管において、 ポリウレタンの外層の厚さは、 0.00254cm乃至0.0635cm(0.001インチ乃至0.025インチ) であり、 ポリエチレンの内層の厚さは、 0.00254cm乃至0.0635cm(0.001インチ乃至0.025インチ) であり、 中間層 の厚さは、 0.00254cm乃至0.0635cm(0.001インチ乃至0.025インチ) である、管。
- 5請求項 1~3のいずれかに 記載の管において、 内層及び外層は、最大 55 MPの応力及び最大 900-950 %のひずみで互いに視覚的に離層しない、管。
- 6請求項 1~3のいずれかに 記載の管において、 管は、36時間60°Cの水に沈水された場合に、視覚的に離層しない、管。
- 7請求項 1~3のいずれかに 記載の管において、 管は、水溶液が流れる中央の軸方向流体通路を有し、 内層は、水溶液と接触する半径方向の内壁面を有し、 外層及び内層は、最大 55 MPの応力及び最大 900-950 %のひずみで互いに視覚的に離層しない、管。
- 8請求項 7 記載の管において、 管は、36時間60°Cの水に沈水された後に、視覚的に離層しない、管。
- 9水溶液の輸送のための医療管であって、 ポリエチレンの 90 重量%以上からなる内層と、 芳香族ポリエーテル系ポリウレタンの 90 重量%以上からなる外層と、 内層と外層との間に配置された中間層であって、エチレンエチルアクリレート共重合体又はエチレンアクリル酸メチル共重合体、または、無水物グラフト結合されたエチレンアクリル酸メチル共重合体、二つ以上の前記アクリレートの共重合体、あるいは、二つ以上のこれらのアクリレート系共重合体の混合物の 90 重量%以上からなる中間層と、を備える、医療管。
- 10請求項 9 記載の医療管において、 内層及び外層は、最大 55 MPの応力及び最大 900-950 %のひずみで互いに視覚的に離層しない、医療管。
- 11請求項 10 記載の医療管において、 管は、36時間60°Cの水に沈水された後に、視覚的に離層しない、医療管。
- 12水溶液の輸送のための医療管であって、 ポリエチレンの少なくとも 90 重量%からなる内層と、 芳香族ポリエーテル系ポリウレタンの少なくとも 90 重量%からなる外層と、 内層と外層との間に配置された中間層であって、エチレンエチルアクリレート共重合体又はエチレンアクリル酸メチル共重合体、または、無水物グラフト結合されたエチレンアクリル酸メチル共重合体、二つ以上の前記アクリレートの共重合体、あるいは、二つ以上のこれらのアクリレート系共重合体の混合物の少なくとも 90 重量%からなる中間層と、を備え、 管は、36時間60°Cの水に沈水された後に、視覚的に離層しない、医療管。
- 13水溶液の輸送のための医療管であって、 低密度ポリエチレンの少なくとも 90 重量%からなる内層と、 ポリテトラメチレングリコール系ポリウレタンの少なくとも 90 重量%からなる外層と、 エチレンエチルアクリレート共重合体、エチレンアクリル酸メチル共重合体、無水物グラフト結合されたエチレンアクリル酸メチル共重合体、前記アクリレートの共重合体、あるいは、二つ以上のこれらのアクリレート系共重合体の混合物の少なくとも 90 重量%からなる中間層と、を備え、 管は、最大 55 MPの応力及び最大 900-950 %のひずみで互いに視覚的に離層せず、 管は、36時間60°Cの水に沈水された後に、視覚的に離層しない、医療管。
- 14外層と、最内層と、外層と最内層との間に配置された中間層と、を備える医療管を形成する方法であって、 選択された構造的安定性を有する第1ポリマー材料を選択するステップと、 水溶液に対して不活性である第2ポリマー材料を選択するステップと、 第1ポリマー材料及び第2ポリマー材料の共押出及び冷却で、第1ポリマー材料及び第2ポリマー材料に容易に結合して付着する第3ポリマー材料を選択するステップと、 外層が第1ポリマー材料の少なくとも 90 %重量からなり、最内層が第2ポリマー材料の少なくとも 90 %重量からなり、中間層が第3ポリマー材料の少なくとも 90 %重量からなるような構成で医療管を形成するために、第1ポリマー材料、第2ポリマー材料及び第3ポリマー材料を共押出しするステップと、を備える方法 であって、 第1ポリマー材料は、ポリウレタンであるように選択され、 第2ポリマー材料は、ポリエチレンであるように選択され、 第3ポリマー材料は、エチレンエチルアクリレート共重合体、エチレンアクリル酸メチル共重合体、無水物グラフト結合されたエチレンアクリル酸メチル共重合体、前記アクリレートの共重合体、二つ以上のこれらのアクリレート系共重合体の混合物、からなる群から選択される、方法。
Independent claims14
14 paragraphs, as filed
The present invention relates to polymer tubes, typically formed by coextrusion, with multiple layers of the same or different polymeric materials, each layer of which is continuously bonded to each other.
Tubes made of polymeric materials are used in commercial applications, including many industrial and medical fields. Various FDA compliant plastics are used depending on the desired properties and intended use. The choice of polymeric material can be a factor when tubes are used to transport fluids for in vivo treatment of human patients.
Polyvinyl chloride (PVC) is one of the most widely used plastics. While structurally stable and easily moldable into the desired shape, PVC typically has other properties that move from the PVC matrix to body fluids and are ideally unsuitable for medical applications. Manufactured using a plasticizer that can. Similarly, due to the unique properties of plasticized PVC tubing, potential absorption of pharmaceuticals and other components of the medically used aqueous solution within the sidewalls of the PVC tubing occurs. Polyurethane is potentially used in place of PVC. However, two-layer tubes made of polyurethane and polyethylene suffer from the incompetence of two layers that remain bonded to each other at low to moderate stress, strain or mechanical operating conditions. U.S. Pat. No. 4,678,844 for Schmitt (Schmitt) incorporated herein by reference as if the disclosure were fully described is SUREPATH by Techni-Plex, Inc. Natvar Division. Disclose a three-layer tube realized in a commercial product sold under 151 (Trademark Registration). As disclosed in Schmitt's literature, the outer layer of PVC and the inner fluid contact layer of low density polyethylene (LDPE) However, Schmitt's literature significantly reduces the potential vinyl acetate copolymer (EVA). However, Schmitt's literature describes the fluid contact of LDPE. The layering greatly reduces the potential for PVC-to-fluid additive transfer and fluid-to-PVC tube component absorption, but PVC elimination is preferred. Other tube configurations are US patents. It is disclosed in No. 7647949, US Pat. No. 4211741 and US Patent Publication No. 2007/0119511, the disclosures of which are incorporated herein by reference as if fully described.
<p num="0004"> According to the present invention, an outer layer of a first selected polymeric material (generally consisting of at least about 90% by weight of polyurethane) and a second selected polymeric material (generally polyethylene). A third polymer material (generally a third polymer material) that is located between the outer layer (consisting of at least about 90% weight) and the inner and outer layers and together bonds the inner and outer layers together by an adhesive mechanism such as chemical adhesion. A tube, tube or tube device having an intermediate layer (consisting of at least about 90% by weight of a copolymer containing acrylate) and at least three concentric layers of a polymeric material comprising. The layers of the polymeric material are coextruded with each other to form a tube such that the outer and inner layers are bonded to the middle or middle layer and thus bonded to each other. The tube forms a central hollow channel, bore or passage that is radially surrounded and defined by a layer of polymeric material that acts as the wall of the tube.</p><p num="0005"> The polymeric material preferably does not contain a smaller amount of potentially unwanted material (generally less than about 0.5% by weight, preferably less than about 0.2% by weight) and / or to humans. Or with the supply of aqueous solutions such as insulin, chemotherapeutic agents and other potentially unstable aqueous drug suspensions from humans, one or the other layer of the three layers comes into contact during the normal process of tube use. Preventing unwanted substances such as plasticizers, catalysts, monomers, metals, salts, ions or other substances that are potentially unwanted to humans from seeping or leaking into the aqueous solution or medium that may be. It is "contaminant-free" which means. In addition to acting as an adhesive between the outer and inner layers and adhering the outer and inner layers, the intermediate layer is an outer and inner layer from the intermediate layer under relatively low conditions to relieve stress and strain. Prevents peeling. In addition, the intermediate layer acts as a barrier against the infiltration or leakage of contaminants from the outer layer to the inner layer or from the outer layer through the inner layer into the hollow central hole or passage of the pipe.</p><p num="0006"> Preferably, the polymer material of the outer layer consists of a polyurethane-based thermoplastic elastomer material (TPU) and the inner layer is polyethylene (PE), typically low density polyethylene (LDPE), linear. It consists of low density polyethylene (LLDPE), high density polyethylene (HDPE) or a mixture thereof, and the intermediate layer or middle layer is an ethylene ethyl acrylate copolymer (EEA), an ethylene methyl acrylate copolymer (EEA). EMA), an anhydride-grafted methyl ethylene acrylate copolymer (AEMA), two or more of the above acrylate copolymers, or a mixture of two or more of these acrylate-based copolymers. Consists of.</p><p num="0007"> With respect to FIGS. 1 and 2, preferably, the polyurethane outer layer 1 has a thickness T3 of about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch), and the inner polyethylene layer has a thickness T1 of about 0.00254. It ranges from cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch), and the intermediate acrylate copolymer layer has a thickness T2 of about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch). Layers 1, 2, and 3 integrally form a tube wall that surrounds and defines the central fluid flow path 20.</p><p num="0008"> Ethylene ethyl acrylate copolymers (EEA), ethylene methyl acrylate copolymers (EMA), and anhydride-grafted methyl acrylate copolymers (AEMA) are elastomeric in nature. Has excellent visual clarity. In a typical 3M3LL coextrusion process, the TPU, EEA or EMA or AEMA and PE are melt extruded through a die head to form a tubular extrusion, then cooled through a typical water bath or water vacuum tank and then cooled. , Winded or cut to a specific length for use. The level of elasticity and flexibility of EEA, EMA, AEMA or their copolymers is controlled by the amount of ethyl acrylate, methyl acrylate comonomer utilized in ethylene in the copolymerization process. Three-layer tubing manufactured by such a coextrusion process act has a stress of up to about 55 MP without delamination between the lamellae after the three-layer tubing is submerged in water at 60 ° C for about 36 hours. And acts like a monolithic returning to its original shape and dimensions after being strained or stretched by a pulling method along the longitudinal axis of the tube with a strain of up to about 900-950%.</p><p num="0009"> According to the present invention, a tube having an inner layer, an outer layer and an intermediate layer is provided, the inner layer is made of polyethylene, the outer layer is made of thermoplastic polyurethane, and the intermediate layer is an ethylene ethyl acrylate copolymer or methyl ethylene acrylate. It comprises a copolymer or an anhydride-grafted methyl ethylene acrylate copolymer, two or more of the above-mentioned acrylate-based copolymers, or a mixture of two or more of these acrylate-based copolymers.</p><p num="0010"> The inner layer typically consists of about 90% by weight or more of polyethylene, the outer layer consists of about 90% by weight or more of aromatic or aliphatic polyether polyurethane, and the intermediate layer consists of ethylene ethyl acrylate copolymer. It consists of about 90% by weight or more.</p><p num="0011"> Polyethylene typically consists of one or more of low density polyethylene, linear low density polyethylene and high density polyethylene, and aromatic polyether polyurethanes typically consist of polytetramethylene glycol polyurethanes. Polyethylene ethyl acrylate copolymers typically contain an ethyl acrylate content of at least 19.5% by weight.</p><p num="0012"> The inner layer typically consists of about 90% by weight or more of polyethylene, the outer layer typically consists of about 90% by weight or more of aromatic polyether polyurethane, and the intermediate layer typically consists of about 90% by weight or more. It consists of about 90% by weight or more of the ethylene ethyl acrylate copolymer.</p><p num="0013"> The inner layer is made up of about 90% by weight or more of low density polyethylene (LDPE), the outer layer is made up of about 90% by weight or more of polytetramethylene glycol-based polyurethane, and the intermediate layer is an anhydride-grafted methyl ethyleneacrylate. It consists of about 90% by weight or more of the copolymer.</p><p num="0014"> Typically, the outer layer of polyurethane has a thickness of about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch), and the inner layer of polyethylene has a thickness of about 0.00254 cm to about 0.0635 cm (about 0.001). The thickness of the intermediate layer of the ethylene ethyl acrylate copolymer is from about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch).</p><p num="0015"> Most preferably, the inner and outer layers are on axis A using a Lioyd LR5K plus mechanical tester at a tensile speed of about 30.48 cm (12 inches) / min under ambient conditions of about 72 degrees Fahrenheit and about 50% relative humidity. Visually delaminate from each other with stresses up to about 55 MP and strains up to about 900-950% measured by pulling a length of tube 10 with an axial length of about 5.08 cm (2 inches) along. However, the break point of tube 10 is about 57-62MPa and about 1000-1050%.</p><p num="0016"> Most preferably, the tube is submerged in water at 60 ° C for 36 hours and then visually flattened by manual squeezing of the tube from a normal circular cross-sectional state to a flat or oval cross-sectional shape or state. Does not separate.</p><p num="0017"> Preferably, the tube has a central axial fluid passage through which the aqueous solution flows, the inner layer has a radial inner wall surface in contact with the aqueous solution, and the outer and inner layers have a stress of up to about 55 MP and a maximum of about 900-. Resists to delamination from each other with a strain of 950%.</p><p num="0018"> According to another aspect of the invention, a medical tube for transporting an aqueous solution is provided. Medical tube With an inner layer consisting of about 90% by weight or more of polyethylene, An outer layer consisting of about 90% by weight or more of aromatic polyether polyurethane, An intermediate layer arranged between the inner layer and the outer layer, which is an ethylene ethyl acrylate copolymer or a methyl acrylate copolymer, or an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more. The copolymer of the above-mentioned acrylate, or an intermediate layer composed of about 90% by weight or more of a mixture of two or more of these acrylate-based copolymers.</p><p num="0019"> In such an embodiment, the inner and outer layers do not visually separate from each other with stresses up to about 55 MP and strains up to about 900-950%. Such tubes preferably do not visually delaminate after being submerged in water at 60 ° C for 36 hours.</p><p num="0020"> According to another aspect of the invention, a medical tube for transporting an aqueous solution is provided. Medical tube With an inner layer consisting of at least about 90% by weight of polyethylene, An outer layer consisting of at least about 90% by weight of aromatic polyether polyurethane, An intermediate layer arranged between the inner layer and the outer layer, which is an ethylene ethyl acrylate copolymer or a methyl acrylate copolymer, or an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more. A copolymer of the above acrylates, or an intermediate layer consisting of at least about 90% by weight of a mixture of two or more of these acrylate-based copolymers. The tube does not visually delaminate after being submerged in water at 60 ° C for 36 hours.</p><p num="0021"> According to another aspect of the invention, a medical tube for transporting an aqueous solution is provided. Medical tube With an inner layer consisting of at least about 90% by weight of low density polyethylene, An outer layer consisting of at least about 90% by weight of polytetramethylene glycol-based polyurethane, An ethylene ethyl acrylate copolymer, a methyl acrylate copolymer, an anhydride-grafted methyl acrylate copolymer, a copolymer of the acrylate, or two or more of these acrylate-based copolymers. With an intermediate layer consisting of at least about 90% by weight of the mixture, The tubes do not visually delaminate from each other with stresses up to about 55 MP and strains up to about 900-950%. The tube does not visually delaminate after being submerged in water at 60 ° C for 36 hours.</p><p num="0022"> Most preferably, the intermediate layer is a monomer, short chain polymer, ion, water, small organic molecule between the outer layer and the inner layer, or from the outer layer to the inner layer or the central flow path, or from the central flow path or the inner layer to the outer layer. Acts as a barrier to the migration of mobile components such as metals, plasticizers, catalysts, etc., preventing or substantially reducing the migration.</p><p num="0023"> Further, according to the present invention, there is provided a method of forming a medical tube including an outer layer, an innermost layer, and an intermediate layer arranged between the outer layer and the innermost layer. The method is With the steps of selecting a first polymer material with selected structural stability, The step of selecting a second polymer material that is inert to the aqueous solution, In the coextrusion and cooling of the first and second polymer materials, the step of selecting a third polymer material that easily bonds and adheres to the first and second polymer materials The outer layer is made up of at least about 90% weight of the first polymer material, the innermost layer is made up of at least about 90% weight of the second polymer material, and the intermediate layer is made up of at least about 90% weight of the third polymer material. It comprises a step of co-extruding a first polymer material, a second polymer material and a third polymer material to form a medical tube.</p><p num="0024"> In such a method, preferably The first polymer material is selected to be polyurethane, The second polymer material is<u style="single">polyethylene</u>Selected to be The third polymer material is an ethylene ethyl acrylate copolymer, a methyl ethylene acrylate copolymer, an anhydride graft-bonded methyl ethylene acrylate copolymer, a copolymer of the acrylate, or two or more of these acrylate-based materials. It is selected from the group consisting of a mixture of copolymers.</p><p num="0025"> Further, according to the present invention, a method of supplying an aqueous solution to a patient is provided. The method is With the step of selecting a tube with an inner layer, an outer layer and an intermediate layer, The inner layer is made of polyurethane The outer layer is made of thermoplastic polyurethane The intermediate layer is an ethylene ethyl acrylate copolymer or a methyl acrylate copolymer, or an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more copolymers of the acrylate, or two. It consists of a mixture of these acrylate-based copolymers as described above. The tube has a central fluid passage surrounded by inner, outer and intermediate layers. The method is The step of flowing the water container in the fluid passage in the center of the pipe, It comprises a step of supplying an aqueous solution flowing through a central fluid passage into the patient's blood vessels.</p><p num="0026"> In such a method, the step of selecting a tube having an inner layer, an outer layer and an intermediate layer is To form the outer layer to be at least about 90% by weight of polyurethane, the inner layer to be at least about 90% by weight of polyethylene, and the intermediate layer to be at least about 90% by weight of one or more acrylate-based copolymers. The step comprises coextruding the outer layer, the inner layer and the intermediate layer.</p><p num="0027"> The drawings show one or more embodiments of the invention set forth in the embodiments of the invention.</p>
<figref num="1">FIG. 1 is a schematic perspective view of a three-layer tube showing a broken outer layer and middle or intermediate layer to better show the configuration and arrangement of the tubes.</figref><figref num="2">FIG. 2 is a cross-sectional view taken along line 2-2 of tube 10 shown in FIG.</figref>
An embodiment of the co-extruded three-layer tube 10 according to the present invention is shown in FIG. 1, wherein the co-extruded three-layer tube 10 is a polyurethane material, typically a poly such as Lubrizol TPU Pellethane 2363-90AE. The outer layer 1 composed of at least about 90% by weight of tetramethylene glycol-based polyurethane and the polyethylene material, typically low density polyethylene of which one example is Westlake LDPE EM808AA, was composed of at least about 90% by weight. The inner fluid contact layer 3 and an ethylene ethyl acrylate copolymer, an ethylene methyl acrylate copolymer, an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more copolymers of the above acrylate, or two. An intermediate bond layer 2 composed of at least about 90% by weight of the above-mentioned mixture of these acrylate-based compounds or compositions is provided. An example of a suitable ethylene ethyl acrylate copolymer is Dow Amplify EA103 (ethylene ethyl acrylate is about 19.5% by weight). An example of a suitable ethylene methyl acrylate copolymer is Westlake MA. SP2268 (ethylene methyl acrylate weighs about 24%), Westlake MA SP2220 (ethylene methyl acrylate weighs about 20%). A suitable anhydrous methyl acrylate copolymer is Westlake Tymax GA 7001 (anhydrous grafted methyl ethylene acrylate).
As shown in FIG. 1, the outer layer 1 of the polyurethane has a radial inward facing surface S1 that binds and adheres to the radial outward facing surface S2 of the acrylate copolymer intermediate layer 2. .. Similarly, the inner layer 3 of the polyethylene material has a radial outward facing surface S4 that binds to and adheres to the radial inwardly facing surface S3 of the acrylate copolymer intermediate layer 2. Intermediate layer 2 of the acrylate copolymer is Lioyd with a pulling speed of about 30.48 cm (12 inches) / min in tube 10 under ambient conditions of about 72 degrees Fahrenheit and about 50% relative humidity. Stress of up to about 55 MP and up to about 900- measured by pulling the length of tube 10 with an axial length of about 5.08 cm (2 inches) along axis A using an LR5K plus mechanical tester. The outer layer 1 and the inner layer 3 adhere to the outer layer 1 and the inner layer 3 and break the tube 10 so that the outer layer 1 and the inner layer 3 remain attached to the intermediate layer 2 and to each other when exposed to 950% strain. The points are about 57-62MPa and about 1000-1050%. Layers 1, 2 and 3 of such a tube 10 are submerged in water at 60 ° C for 36 hours, followed by manual operation of the tube from a normal circular cross-sectional state to a flat or oval cross-sectional shape or state. Does not visually delaminate after being flattened by squeezing.
As shown in FIGS. 1 and 2, in layers 1, 2 and 3, a central hollow fluid passage 20 through which an aqueous solution in contact with S5 facing inward in the radial direction of the inner layer 3 is sent in the axis A direction and flows. It is formed on a structurally stable wall that surrounds the. The intermediate layer 2 holds the inner layer 3 and the outer layer 1 together.
The inner layer 3 provides a radial inward fluid contact surface S5, and the thickness of the inner layer 3 is generally about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch) transverse thickness. It is in the range of T1. The intermediate layer 2 provides a radial inward fluid contact surface S5, and the thickness of the inner layer 3 is generally about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch) transverse thickness. It is in the range of T2. The outer layer 1 provides a radial inward fluid contact surface S5, and the thickness of the inner layer 3 is generally about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch) transverse thickness. It is in the range of T3.
The polyethylene material is preferably branched chain low density polyethylene (LDPE) such as Westlake EM808 available from Westlake Chemical Corporation. The polyethylene material can be linear low density polyethylene (LLDPE), such as Dowlex 2035G, available from the Dow Chemical Company. The polyethylene material can also be high density polyethylene (HDPE) such as Chevron 9506 HDPE, Chevron 9406 HDPE and Chevron 9503 HDPE available from Chevron Corporation.
Polyurethane elastomers (TPUs) are generally the reaction products of polyols and isocyanates and usually include a combination of hard and soft segment domains. As the aromatic polyether-based TPU or the aliphatic polyether-based TPU, polytetramethylene glycol-based polyurethane or the like can be used. Preferably, the TPU includes the Pellethane 2363-90AE series available from the Lubrizol Corporation, such as the Lubrizol TPU Pellethane 2363-90AE.
The thickness of each layer of tubes 10 and 20 can be controlled by extrusion tools such as the "Tri Die" extruder manufactured by the Genca Division of Clearwater, Florida's General Cable Company. The extruder is selected to provide a uniform thickness of layers 1, 2 and 3 along approximately the entire length of all axial lengths L of the three layers 1, 2 and 3.
The polymeric material in which the layers 1, 2 and 3 are composed is selected to be visually clear or transparent and manually flexible about axis A along axis A of the tube. Also, the polymeric material is selected to maintain intact (ie, no delamination) and transparency or clarity of the tube 10 after being subjected to ethylene oxide (EtO) and gamma irradiation sterilization. ..
The above description is intended to illustrate the invention and not to limit the scope of the invention. However, one of ordinary skill in the art considers the equivalent thereof as described above, and changes and modifications are made in the spirit of the present invention. All such equivalents, modifications and modifications are made without deviation from the patent of the present invention. You will understand that it is within the scope of the request.<u style="single">The present invention includes the following aspects.</u><u style="single"> [1]</u><u style="single"> A tube having an inner layer, an outer layer and an intermediate layer.</u><u style="single"> The inner layer is made of polyethylene</u><u style="single"> The outer layer is made of thermoplastic polyurethane</u><u style="single"> The intermediate layer is an ethylene ethyl acrylate copolymer or a methyl acrylate copolymer, or an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more of the acrylate-based copolymers, or two. A tube made of the above-mentioned mixture of these acrylate-based copolymers.</u><u style="single"> [2]</u><u style="single"> In the tube described [1]</u><u style="single"> The inner layer consists of about 90% by weight or more of polyethylene and</u><u style="single"> The outer layer consists of about 90% by weight or more of aromatic or aliphatic polyether polyurethane.</u><u style="single"> The intermediate layer is a tube made of about 90% by weight or more of the ethylene ethyl acrylate copolymer.</u><u style="single"> [3]</u><u style="single"> In the tube described [2]</u><u style="single"> Polyethylene consists of one or more of low density polyethylene, linear low density polyethylene and high density polyethylene.</u><u style="single"> Aromatic polyether-based polyurethane consists of polytetramethylene glycol-based polyurethane.</u><u style="single"> Ethylene ethyl acrylate copolymer is a tube containing an ethyl acrylate content of at least 19.5% by weight.</u><u style="single"> [4]</u><u style="single"> In the tube described [1]</u><u style="single"> The inner layer consists of about 90% by weight or more of polyethylene and</u><u style="single"> The outer layer consists of about 90% by weight or more of aromatic polyether polyurethane.</u><u style="single"> The intermediate layer is a tube composed of about 90% by weight or more of the ethylene methyl acrylate copolymer.</u><u style="single"> [5]</u><u style="single"> In the tube described [4]</u><u style="single"> Polyethylene consists of one or more of low density polyethylene, linear low density polyethylene and high density polyethylene.</u><u style="single"> Aromatic polyether-based polyurethane consists of polytetramethylene glycol-based polyurethane.</u><u style="single"> Ethylene methyl acrylate copolymer is a tube containing an ethyl acrylate content of at least 19.5% by weight.</u><u style="single"> [6]</u><u style="single"> In the tube described [1]</u><u style="single"> The inner layer consists of about 90% by weight or more of low density polyethylene (LDPE) and</u><u style="single"> The outer layer consists of about 90% by weight or more of polytetramethylene glycol-based polyurethane.</u><u style="single"> The intermediate layer is a tube composed of about 90% by weight or more of the methyl acrylate copolymer bonded with an anhydride graft.</u><u style="single"> [7]</u><u style="single"> In the tube described [1]</u><u style="single"> The thickness of the outer layer of polyurethane is from about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch).</u><u style="single"> The thickness of the inner layer of polyethylene is about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch).</u><u style="single"> The thickness of the intermediate layer of the ethylene ethyl acrylate copolymer is from about 0.00254 cm to about 0.0635 cm (about 0.001 inch to about 0.025 inch), tube.</u><u style="single"> [8]</u><u style="single"> In the tube described [1]</u><u style="single"> The inner and outer layers are tubes that do not visually separate from each other with stresses up to about 55 MP and strains up to about 900-950%.</u><u style="single"> [9]</u><u style="single"> In the tube described [1]</u><u style="single"> The tube does not visually delaminate when submerged in water at 60 ° C for 36 hours.</u><u style="single"> [10]</u><u style="single"> In the tube described [1]</u><u style="single"> The tube has a central axial fluid passage through which the aqueous solution flows.</u><u style="single"> The inner layer has a radial inner wall that comes into contact with the aqueous solution.</u><u style="single"> The outer and inner layers are tubes that do not visually separate from each other with stresses up to about 55 MP and strains up to about 900-950%.</u><u style="single"> [11]</u><u style="single"> In the tube described [10]</u><u style="single"> The tube does not visually delaminate after being submerged in water at 60 ° C for 36 hours.</u><u style="single"> [12]</u><u style="single"> A medical tube for transporting aqueous solutions</u><u style="single"> With an inner layer consisting of about 90% by weight or more of polyethylene,</u><u style="single"> An outer layer consisting of about 90% by weight or more of aromatic polyether polyurethane,</u><u style="single"> An intermediate layer arranged between the inner layer and the outer layer, which is an ethylene ethyl acrylate copolymer or a methyl ethylene acrylate copolymer, or an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more. A medical tube comprising the copolymer of the above-mentioned acrylate or an intermediate layer composed of about 90% by weight or more of a mixture of two or more of these acrylate-based copolymers.</u><u style="single"> [13]</u><u style="single"> [12] In the medical tube described</u><u style="single"> A medical tube in which the inner and outer layers do not visually separate from each other with a stress of up to about 55 MP and a strain of up to about 900-950%.</u><u style="single"> [14]</u><u style="single"> [13] In the medical tube described</u><u style="single"> The tube is a medical tube that does not visually delaminate after being submerged in water at 60 ° C for 36 hours.</u><u style="single"> [15]</u><u style="single"> A medical tube for transporting aqueous solutions</u><u style="single"> With an inner layer consisting of at least about 90% by weight of polyethylene,</u><u style="single"> An outer layer consisting of at least about 90% by weight of aromatic polyether polyurethane,</u><u style="single"> An intermediate layer arranged between the inner layer and the outer layer, which is an ethylene ethyl acrylate copolymer or a methyl acrylate copolymer, or an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more. A copolymer of the above acrylates, or an intermediate layer consisting of at least about 90% by weight of a mixture of two or more of these acrylate-based copolymers.</u><u style="single"> The tube is a medical tube that does not visually delaminate after being submerged in water at 60 ° C for 36 hours.</u><u style="single"> [16]</u><u style="single"> A medical tube for transporting aqueous solutions</u><u style="single"> With an inner layer consisting of at least about 90% by weight of low density polyethylene,</u><u style="single"> An outer layer consisting of at least about 90% by weight of polytetramethylene glycol-based polyurethane,</u><u style="single"> An ethylene ethyl acrylate copolymer, a methyl acrylate copolymer, an anhydride-grafted methyl acrylate copolymer, a copolymer of the acrylate, or two or more of these acrylate-based copolymers. With an intermediate layer consisting of at least about 90% by weight of the mixture,</u><u style="single"> The tubes do not visually delaminate from each other with stresses up to about 55 MP and strains up to about 900-950%.</u><u style="single"> The tube is a medical tube that does not visually delaminate after being submerged in water at 60 ° C for 36 hours.</u><u style="single"> [17]</u><u style="single"> A method of forming a medical tube comprising an outer layer, an innermost layer, and an intermediate layer arranged between the outer layer and the innermost layer.</u><u style="single"> With the steps of selecting a first polymer material with selected structural stability,</u><u style="single"> The step of selecting a second polymer material that is inert to the aqueous solution,</u><u style="single"> In the coextrusion and cooling of the first and second polymer materials, the step of selecting a third polymer material that easily bonds and adheres to the first and second polymer materials</u><u style="single"> The outer layer is made up of at least about 90% weight of the first polymer material, the innermost layer is made up of at least about 90% weight of the second polymer material, and the intermediate layer is made up of at least about 90% weight of the third polymer material. A method comprising coextruding a first polymer material, a second polymer material and a third polymer material to form a medical tube.</u><u style="single"> [18]</u><u style="single"> [17] The method described</u><u style="single"> The first polymer material is selected to be polyurethane,</u><u style="single"> The second polymer material was selected to be polyethylene,</u><u style="single"> The third polymer material is an ethylene ethyl acrylate copolymer, a methyl ethylene acrylate copolymer, an anhydride graft-bonded methyl ethylene acrylate copolymer, a copolymer of the acrylate, or two or more of these acrylate-based materials. A method selected from the group consisting of a mixture of copolymers.</u><u style="single"> [19]</u><u style="single"> A method of supplying an aqueous solution to a patient</u><u style="single"> With the step of selecting a tube with an inner layer, an outer layer and an intermediate layer,</u><u style="single"> The inner layer is made of polyurethane</u><u style="single"> The outer layer is made of thermoplastic polyurethane</u><u style="single"> The intermediate layer is an ethylene ethyl acrylate copolymer or a methyl acrylate copolymer, or an anhydride graft-bonded methyl ethylene acrylate copolymer, two or more copolymers of the acrylate, or two. It consists of a mixture of these acrylate-based copolymers as described above.</u><u style="single"> The tube has a central fluid passage surrounded by inner, outer and intermediate layers.</u><u style="single"> The method is</u><u style="single"> The step of flowing the water container in the fluid passage in the center of the pipe,</u><u style="single"> A step of supplying an aqueous solution flowing through a central fluid passage into a patient's blood vessel.</u><u style="single">Method.</u><u style="single"> [20]</u><u style="single"> [19] The method described</u><u style="single"> The step of selecting a tube having the inner layer, the outer layer and the intermediate layer is</u><u style="single"> To form the outer layer to consist of at least about 90% by weight of polyurethane, the inner layer to consist of at least about 90% by weight of polyethylene, and the intermediate layer to consist of at least about 90% by weight of one or more acrylate-based copolymers. A method comprising the steps of coextruding an outer layer, an inner layer and an intermediate layer.</u>
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Every citation, both ways
| Document | Relation | Office |
|---|---|---|
| JP10305093A | Cites | Japan |
| JP2003251680A | Cites | Japan |
| JP2008132659A | Cites | Japan |
48 members in 11 offices
Priority claims9
| Document | Office | Kind | Date |
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| 201213354029 | United States of America | A | |
| 201213354029 | United States of America | A | |
| 2012062565 | United States of America | W | |
| 2012062565 | United States of America | W | |
| 13354029 | – | – | – |
| US2012062565 | – | – | – |
| US201213354029 | – | – | – |
| WO2012US62565 | – | – | – |
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| JP2015535326A | Japan | A | |
| EP2885047B1 | European Patent Office (EPO) | B1 | |
| EP3090777A1 | European Patent Office (EPO) | A1 | |
| JP6027682B2 | Japan | B2 | |
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Numbers
- Publication
- 6203754
- Publication, DOCDB
- 6203754
- Publication, EPODOC
- JP6203754B
- Application
- 2014553288
- Application, DOCDB
- 2014553288
- Application, EPODOC
- JP20140553288
Titles2
- Japanese
- 複層管
- English
- Multi-layer tube
Classification
- CPC, 13
- A61M39/08
- B32B1/08
- B32B27/308
- B32B27/32
- B32B27/40
- B32B2535/00
- B32B2597/00
- F16L11/04
- F16L11/10
- F16L11/12
- B29C48/18
- B29C48/22
- B29C48/09
- IPC, 12
- B32B1 08
- A61M39 08
- B29C48 09
- B29C48 18
- B29C48 22
- B32B27 30
- B32B27 32
- B32B27 40
- F16L11 04
- B29C47 06
- B29L9 00
- B29L23 00
