Ptp sheet for medicine packaging

The present invention relates to PTP sheet for drug packaging concerns.

PTP (Press Through Package) packaging is widely used in the field of pharmaceutical packaging for packaging solid drugs such as tablets and capsules. The PTP packaging is mainly a packaging body (hereinafter, simply referred to as aluminum foil) in which a pocket containing a drug is molded into a resin film, the pocket is filled with the drug, and then the pocket is sealed with a sheet made of aluminum foil (hereinafter, simply referred to as aluminum foil). Sheet).

The drug is removed from the PTP sheet by the following procedure. When the patient presses the drug through the pocket with his fingertips, the pocket elastically deforms and the drug is pressed against the aluminum foil. The drug breaks the aluminum foil and removes the drug out of the pocket.

Multiple PTP sheets may be placed on top of each other during storage and transportation of the drug, or when the drug is carried by the patient. At that time, the PTP sheets are often superposed so that the surfaces on the side where the pockets are projected are close to each other. In such a state, since the pocket of the other PTP sheet fits into the space between the pockets of one PTP sheet, the thickness in the state where a plurality of PTP sheets are stacked can be suppressed to be thin. At the same time, it is possible to prevent the pocket from being directly pressed by an external force. Hereinafter, this state is also referred to as a tying state. Patent Document 1 discloses an apparatus and a method for realizing a tying state of PTP sheets at high speed.

<p num="0005"><patcit num="1"><text>Japanese Unexamined Patent Publication No. 2011-37527</text></patcit></p>

<p num="0006"> In the state where the PTP sheets are tied together, the pockets are in contact with the opposing PTP sheets. Therefore, when both outer surfaces of the laminated body of the PTP sheets in the tying state are pressed against each other, the pockets are pressed by the opposing PTP sheets and deformed, or the aluminum foil is broken by the chemical pressed through the pockets. It may be scratched. Alternatively, when the drug is a capsule or the like, the capsule may be deformed by pressing.</p><p num="0007"> For example, when a patient carries a PTP sheet containing a drug in a bag or the like, the outer surfaces of the laminated body of the PTP sheets in a tying state are pressed by other articles, as described above. Phenomena may occur.</p><p num="0008"> The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a PTP sheet capable of protecting a pocket from being pressed by an external force in a tying state.</p>

<p num="0009"> (1) The PTP sheet for drug packaging according to the present invention includes a first sheet in which a pocket capable of accommodating a drug and a protruding convex portion protrude from the first surface, which is one of the front and back surfaces, and the above-mentioned first sheet. It is provided with a second sheet that is attached to the second surface of one sheet opposite to the first surface and closes the opening of the pocket. The first distance from the first surface to the protruding end of the convex portion is longer than the second distance from the first surface to the protruding end of the pocket.</p><p num="0010"> According to the PTP sheet for drug packaging having such a configuration, each of the convex portions abuts on the first surface of the first sheet of the PTP sheet for drug packaging facing each other in the tying state. Since the opposing PTP sheets for drug packaging are supported by the protrusions, a certain gap is formed between the PTP sheets for drug packaging. Since the first distance from the first surface to the protruding end of the convex portion is longer than the second distance from the first surface to the protruding end of the pocket, the pocket does not come into contact with the opposing PTP sheet for drug packaging. Be maintained.</p><p num="0011"> In the tying state, when both outer surfaces of the laminated body of the PTP sheets in the tying state are pressed against each other, when both outer surfaces are pressed, the pressing force is absorbed by the convex portion. Therefore, the opposing PTP sheet for drug packaging prevents the pocket from being pressed.</p><p num="0012"> (2) The protruding end of the convex portion may be a plane parallel to the first surface.</p><p num="0013"> Since the protruding end of the convex portion is flat, the convex portion can stably support the opposing PTP sheet for drug packaging.</p><p num="0014"> (3) The protruding end of the convex portion may have a concave recess in the central portion and may have a circular shape parallel to the first surface.</p><p num="0015"> By forming a recess at the protruding end of the convex portion, the convex portion can more stably support the opposing PTP sheet for drug packaging. Further, by forming a recess at the protruding end of the convex portion, when the patient takes the drug, the pocket in which the drug is stored can be distinguished from the convex portion, and the convenience can be further improved. ..</p><p num="0016"> (4) A plurality of the pockets are provided, and a pair of the convex portions may be provided on both outer sides of the pocket.</p><p num="0017"> By providing a pair of convex portions for each pocket, the gap between the PTP sheets for drug packaging can be reliably maintained around the pocket.</p><p num="0018"> (5) The PTP sheet for drug packaging may have a rectangular shape in a plan view. Each of the pockets and the protrusions may be asymmetric in a virtual straight line along the center of the rectangle in the longitudinal direction or the lateral direction.</p><p num="0019"> According to such an arrangement of the pockets and the convex portions, even if the PTP sheets for drug packaging are joined together with the peripheral edges aligned, the opposing pockets and the convex portions do not come into contact with each other. Since the PTP sheet for drug packaging can be in a tying state with the sheet peripheral edges aligned, the tying state can be stabilized and at the same time, space saving can be contributed.</p><p num="0020"> The rectangular shape in the present invention includes a rectangular shape having a curved peripheral portion of the corner. That is, the PTP sheet for drug packaging whose four corners are R-processed also belongs to the technical scope of the present invention. Further, when the rectangle is a square, which of the directions along the two orthogonal sides may be interpreted as the lateral direction or the longitudinal direction.</p><p num="0021"> Further, in the present invention, when two pockets or convex portions are "asymmetric", it is assumed that one pocket or convex portion is transferred to a symmetrical position, and the area occupied by the pocket or convex portion after transfer is assumed. And the area occupied by the other pocket or protrusion are at least separated to the extent that they do not overlap.</p><p num="0022"> (6) In a plan view, all the pockets are arranged along the first direction, and the pair of the convex portions are arranged along the second direction orthogonal to the first direction. Orthogonal<u style="single">Cutting part for dividing the PTP sheet for drug packaging</u>May be provided along the second direction, respectively.</p><p num="0023"> (7) The first sheet may have at least a writing area on at least a part of the first surface on which characters or patterns can be written with a pencil or a ballpoint pen.</p><p num="0024"> In the entry area, the pharmacist can enter patient-specific information about the use of the drug (eg, when to take it). In the tying state, since the entry area does not come into contact with the opposing PTP sheet for drug packaging, it is possible to prevent the characters and patterns written in the entry area from fading or bleeding.</p><p num="0025"> (8) The region where each of the convex portions occupies the first sheet is symmetrically transferred in the virtual straight line along the center of the rectangular direction in the longitudinal direction or the lateral direction, and the region overlaps with the entry region. Absent.</p><p num="0026"> In this configuration, since the entry area is not provided at the position where it comes into contact with the convex portion in the tying state, the possibility that the characters and patterns written in the entry area are faint or blurred is further reduced.</p>

<p num="0027"> According to the PTP sheet for drug packaging according to the present invention, the pocket can be protected from being pressed by an external force in the tying state.</p>

<figref num="1">FIG. 1 is an external perspective view of the PTP sheet 10 divided into 12 cells. (A) indicates a state in which the drug 11 is not contained, and (B) indicates a state in which the drug 11 is contained.</figref><figref num="2">FIG. 2 is an external perspective view of the PTP sheet 10 in which the two cells 12 are combined.</figref><figref num="3">FIG. 3 is a diagram showing the PTP sheet 10 divided into 12 cell units by the third trigonometry.</figref><figref num="4">FIG. 4 is a diagram showing a state in which two PTP sheets 10L and 10H are in a tying state. (A) is a plan view. (B) is a cross-sectional view of the BB cutting line of (A).</figref><figref num="5">FIG. 5 is a diagram showing a convex portion 18 according to a modification 1 of the PTP sheet 10. (A) is a plan view. (B) is a cross-sectional view of the BB cutting line of (A).</figref><figref num="6">FIG. 6 is a plan view showing different arrangements of the pockets 16L and 16H and the convex portions 18L and 18H in the tying state. (A) is the second modification of the embodiment of the present invention, and (B) is the third modification.</figref><figref num="7">FIG. 7 is a plan view showing different arrangements of the pockets 16L, 16H and the protrusions 18L, 18H. (A) shows the unembedded PTP sheet 10. (B) shows a state in which the PTP sheet 10H is turned upside down so as to be inverted in the front-rear direction 6 and is hugged with the PTP sheet 10L. (C) shows a state in which the PTP sheet 10H is turned upside down so as to be inverted in the left-right direction 7 and is entwined with the PTP sheet 10L.</figref>

Hereinafter, embodiments of the present invention will be described with reference to the drawings as appropriate. It goes without saying that the embodiments described below are merely examples of the present invention, and the embodiments of the present invention can be appropriately changed without changing the gist of the present invention. In the following description, the vertical direction 5 is defined with reference to the vertical direction, the front-rear direction 6 is defined in the direction perpendicular to the vertical direction 5, and the horizontal direction 7 is defined in the direction perpendicular to the vertical direction 5 and the front-rear direction 6, respectively. It is defined. Here, the front-rear direction 6 is an example of the first direction of the present invention, and the left-right direction 7 is an example of the second direction of the present invention.

[Outline configuration of PTP sheet 10] As shown in FIGS. 1A and 1B, the PTP sheet 10 is a rectangular sheet in a plan view. As shown in FIG. 1 (B), the PTP sheet 10 is carried out in a state where tablets and capsules (hereinafter, these are collectively referred to as drug 11) are sealed inside. Further, in the example of FIG. 2, two cells 12 (an example of one division of the present invention), which is a division for sealing one medicine 11, are arranged in the front-rear direction 6 to form a PTP sheet 10. .. That is, a total of two agents 11 are sealed in the PTP sheet 10 of FIG.

A slit 13 (an example of a cut portion of the present invention) is formed at the boundary of the cell 12. The PTP sheet 10 can be folded or detached along the slit 13 by the hands of a pharmacist or patient and divided into a single cell 12. The dimension of cell 12 in the anteroposterior direction 6 is 4 to 12 cm, preferably 5 to 6 cm. In this embodiment, an example of 5.5 cm is shown. The dimension of 7 in the left-right direction is 4 to 7 cm, preferably 5.5 to 6.5 cm. In this embodiment, an example of 5.8 cm is shown. In the following description, a set of a plurality of undivided cells 12 and a single cell 12 after being divided are referred to as PTP sheets 10, respectively.

The PTP sheet 10 is formed by sticking a first sheet 14 molded of polypropylene and a second sheet 15 which is an aluminum film. The drug 11 is housed in the pocket 16 formed in the first sheet 14. The opening of the pocket 16 is closed by the second seat 15. When the pocket 16 of the first sheet 14 is pressed by the patient's fingertip, the pocket 16 elastically deforms and presses the drug 11 toward the second sheet 15. When the drug 11 pushes through the second sheet 15, the drug 11 is removed from the pocket 16 through the opening.

When the PTP sheet 10 is stored, transported, or carried by a patient, the first sheets 14 are superposed on each other so as to be in a tying state. The tying state is a state in which the pockets 16 of the other PTP sheet 10 are inserted into the space between the pockets 16 of one PTP sheet 10 and the pockets 16 are arranged alternately. The convex portion 18 protrudes from the surface of the first sheet 14 on the same side as the pocket 16. In the PTP sheet 10 according to the present embodiment, in the tying state, the convex portion 18 supports the other PTP sheet 10, so that the pocket 16 is maintained in a state where it does not come into contact with the PTP sheet 10 on the opposite side. ..

Hereinafter, each component of the PTP sheet 10 will be described in more detail. In the following description, the expressions "upper surface" and "lower surface" of each sheet may be used, but these are based on the orientation of the PTP sheet 10 in FIGS. 1 and 2. Further, the upper surface of the first sheet 14 (the surface on the side where the pocket 16 is projected) is the first surface of the present invention, and the lower surface (the surface on the side where the second sheet 15 is attached) is the second surface of the present invention. Corresponds to each.

[1st sheet 14] The first sheet 14 shown in FIGS. 1 to 3 is a sheet vacuum formed from polypropylene (PP) which is a thermoplastic resin. The first sheet 14 has a certain degree of translucency. As a result, the patient can see through the first sheet 14 and visually recognize the characters and symbols described on the second sheet 15 which will be described later.

However, as long as the first sheet 14 has a translucency to the extent that the characters and patterns described on the second sheet 15 can be visually recognized and can be elastically deformed by pressing the fingertips. Other resins may be used. For example, polyvinyl chloride (PVC), polyethylene terephthalate (PET), or cyclic polyolefin may be used for the first sheet 14. Alternatively, the resin layer may be coated with different thin films to form the first sheet 14. Alternatively, the first sheet 14 may be formed by laminating two or more types of resin layers.

As shown in FIG. 2, the first sheet 14 has a rectangular shape when it is not divided into 12 cells. However, the portions corresponding to the four corners of each cell 12 are cut in a curved shape. This is to prevent the patient from injuring his hand by the corner of cell 12.

In FIG. 2, a slit 13 is formed at the boundary of the cell 12. The slit 13 is a substantially V-shaped groove formed on the upper surface of the first sheet 14, and the depth of the slit 13 is slightly deeper than half the thickness of the first sheet 14. Alternatively, the slit 13 may be a perforation in which minute holes are periodically formed. Alternatively, the slit 13 may be provided in which the groove and the perforation are overlapped with each other. In the manufacturing stage of the PTP sheet 10, the roller-shaped blade moves relatively while pressing the upper surface of the first sheet 14. In this way, the slit 13 is formed in the first sheet 14.

The cell 12 after being divided has a rectangular shape in a plan view. The dimension of cell 12 in the front-rear direction 6 is 5.5 cm, and the dimension of cell 12 in the left-right direction 7 is 5.8 cm. This is large enough to prevent the patient from accidentally swallowing. However, the dimensions of each cell 12 are not limited to this. For example, the cell 12 may have a square shape in a plan view because the dimensions in the front-rear direction 6 and the dimensions in the left-right direction 7 are equal to each other. Alternatively, the cell 12 may have a larger dimension in the front-rear direction 6 than a dimension in the left-right direction 7.

Of the first sheet 14, one pocket 16 is provided in each cell 12. The pocket 16 is provided in each cell 12 slightly behind the center of the front-rear direction 6 and slightly to the right of the center of the left-right direction 7.

The pocket 16 is formed in a dome shape so that the first sheet 14 projects upward. That is, in the pocket 16, the upper surface of the first sheet 14 is projected upward, and the lower surface is depressed upward. An internal space for accommodating the drug 11 is formed in this depressed portion. An opening that connects the internal space and the external space is opened on the lower surface side of the first sheet 14. The size of the pocket 16 is capable of completely accommodating the drug 11, and is appropriately changed depending on the size of the drug 11.

Of the first sheet 14, two convex portions 18 are provided in each cell 12. The two protrusions 18 are provided in each cell 12 slightly in front of the pocket 16. The two convex portions 18 are separated from the pocket 16 on both outer sides in the left-right direction 7 to form a pair.

The convex portion 18 is a dome-shaped first sheet 14 similar to the pocket 16. On the other hand, the difference from the pocket 16 is that the drug 11 is not housed in the internal space formed by the convex portion 18. The protruding end of the convex portion 18 is formed in a shape that is circular in a plan view and the central portion slightly bulges upward. As shown in FIG. 4 (B), the convex portion 18 supports the PTP sheet 10 on the opposite side in the assembled state of the PTP sheet 10. The details of the tying state will be described later. In FIGS. 4, 6 and 7, in order to distinguish the two PTP sheets 10 in the tying state, "L" is added to the end of the reference code related to the lower PTP sheet 10 and the upper PTP sheet 10 is used. An "H" is added to the end of the relevant reference code.

The distance L1 from the upper surface of the first sheet 14 to the protruding end of the convex portion 18 (FIG. 4 (B), an example of the first distance of the present invention) is the distance from the upper surface of the first sheet 14 to the protruding end of the pocket 16. It is taken longer than L2 (Fig. 4 (B), an example of the second distance of the present invention). Since the distance L2 is appropriately changed according to the size of the sealed drug 11, the distance L1 is also appropriately changed according to the distance L2. When the drug 11 is a general tablet, the distance L2 is 5 to 8 mm, and the distance L1 is 1 to 3 mm longer than the distance L2. In this embodiment, the distance L1 is 7 mm and the distance L2 is 5 mm.

As shown in FIGS. 1 to 3, a sticker 20 is attached further in front of the convex portion 18. The sticker 20 is a paper sheet cut into a strip shape. Adhesive is applied to one of the front and back surfaces of the seal 20. The seal 20 is attached to the upper surface of the first sheet 14 by this adhesive with the left-right direction 7 as the longitudinal direction. Of the front and back surfaces of the seal 20, the side on which the adhesive is not applied is exposed upward. On this surface, a pharmacist can write information about the drug 11 with a writing tool such as a pencil or ballpoint pen. Of the upper surface of the first sheet 14, the area to which the sticker 20 is attached is an example of the entry area of the present invention.

In the PTP sheet 10 before division shown in FIG. 2, all the pockets 16 and the protrusions 18 are asymmetrically arranged in the virtual straight line V1 along the center of the PTP sheet 10 in the front-rear direction 6. That is, neither the pocket 16 nor the convex portion 18 is provided at a position symmetrical with each of the pocket 16 and the convex portion 18 and the virtual straight line V1. Further, the seal 20 is arranged at an asymmetrical position on the convex portion 18 and the virtual straight line V1. That is, the seal 20 is not provided at a position symmetrical with the convex portion 18 in the front-rear direction 6. Similarly, in individual cells 12, all pockets 16 and protrusions 18 are asymmetrically arranged in a virtual straight line V2 along the center of cell 12 in the anteroposterior direction 6. Further, the seal 20 is arranged at an asymmetrical position on the convex portion 18 and the virtual straight line V2. The reason will be described later. The virtual straight lines V1 to V3 including the virtual straight line V3 described later are an example of the virtual straight line of the present invention.

[2nd sheet 15] The second sheet 15 is an aluminum film attached to the lower surface side of the first sheet 14 in a state where the drug 11 is housed in the pocket 16. The opening of the pocket 16 is closed by the second sheet 15, and the drug 11 is sealed inside the pocket 16.

The thickness of the second sheet 15 is set so that when the patient presses the drug 11 through the pocket 16, the second sheet 15 is torn by the pressing force from the drug 11. In this embodiment. The thickness of the second sheet 15 is 20 μm. However, the thickness of the second sheet 15 may be appropriately changed depending on the hardness of the drug 11, for example, whether the drug 11 is a tablet or a capsule. Further, as the material of the second sheet 15, a material other than aluminum may be used as long as it satisfies the above requirements. For example, the second sheet 15 may be a metal other than aluminum, or may be an alloy of aluminum and another metal. Further, another chemical material may be used for the second sheet 15 as long as the airtightness of the pocket 16 can be ensured.

With the drug 11 contained in the pocket 16, the first sheet 14 and the second sheet 15 are crimped in a heated state. At that time, the lower surface of the first sheet 14, which is semi-melted by heat, solidifies, so that the first sheet 14 and the second sheet 15 are welded together.

Although not shown in the figure, characters and patterns that can be visually recognized by the pharmacist and the patient are written on the upper surface and the lower surface of the second sheet 15, respectively. The characters and patterns written on the upper surface of the second sheet 15 pass through the first sheet 14 and can be visually recognized from the upper surface of the first sheet 14.

[Tying of PTP sheet 10] Hereinafter, the tying state of the PTP sheet 10 will be described with reference to FIGS. 4 (A) and 4 (B). The two PTP sheets 10L and 10H are superposed so that the first sheets 14L and 14H face each other. Then, in the two PTP sheets 10L and 10H, the front end 21 and the rear end 22 shown in FIG. 2 coincide with each other in the front-rear direction 6. That is, the PTP sheet 10L is in the state shown in FIG. 2, and the PTP sheet 10H is turned inside out so that the front-rear direction 6 is reversed from the state shown in FIG. Then, the PTP sheet 10H is put on the PTP sheet 10L.

As described above, in each PTP sheet 10, the pocket 16 and the convex portion 18 are arranged asymmetrically in the virtual straight lines V1 and V2. Therefore, in the tying state, the opposing pockets 16L and 16H and the convex portions 18L and 18H are not in contact with each other.

In FIG. 4A, convex portions 18L are arranged on both outer sides of the pocket 16H in the left-right direction 7. In addition, convex portions 18H are arranged on both outer sides of the pocket 16L in the left-right direction 7. The convex portions 18L and 18H are in contact with and support the first sheets 14L and 14H of the opposing PTP sheets 10L and 10H, respectively. As a result, the gap of the distance L1 (FIG. 4 (B)) is maintained between the first sheets 14L and 14H. Since the distance L2 is shorter than the distance L1, the pockets 16L and 16H are kept out of contact with the opposing PTP sheets 10L and 10H due to this gap. Since the pockets 16L and 16H are arranged inside the convex portions 18L and 18H in the left-right direction 7, this gap is maintained around the pockets 16L and 16H even when the PTP sheet 10L and 10H are bent. Cheap.

In addition, when two PTP sheets 10L, 10H are relatively displaced in the left-right direction 7 or the front-back direction 6 in the tying state, the pockets 16L, 16H or the convex portions 18L, 18H come into contact with each other to prevent movement. Will be done. Hereinafter, a detailed description will be given. When the PTP sheet 10H is slightly displaced rearward with respect to 10L, the pockets 16L and 16H come into contact with each other to prevent further movement. When the PTP sheet 10H is slightly displaced forward with respect to 10L, the convex portions 18L and 18H come into contact with each other to prevent further movement. When the PTP sheet 10H is slightly shifted to the left with respect to 10L, the pocket 16L comes into contact with the convex portion 18H on the right side to prevent further movement. When the PTP sheet 10H is slightly shifted to the right with respect to 10L, the pocket 16H comes into contact with the convex portion 18L on the right side to prevent further movement. That is, the range in which the two PTP sheets 10L and 10H can be relatively displaced in the left-right direction 7 and the front-rear direction 6 is limited to a narrow range.

As described above, in each PTP sheet 10, the seal 20 is arranged at an asymmetrical position on the convex portion 18 and the virtual straight lines V1 and V2. Therefore, in the tying state, the protruding ends of the convex portions 18L and 18H come into contact with the PTP sheets 10L and 10H at positions different from those of the seals 20L and 20H.

In the PTP sheet 10 before division shown in FIG. 2, the cell 12 on the rear side can be bent in the direction 19 with the slit 13 as a bending line. In the bent state, the front cell 12 and the rear cell 12 realize a state similar to the above-mentioned tying state. The folded PTP sheet 10 is maintained in a state in which the pocket 16 does not come into contact with the facing cell 12 as in the tying state.

[Action and effect of the embodiment] Since the PTP sheet 10 according to the present embodiment is maintained in a state in which the pocket 16 does not come into contact with the opposing PTP sheet 10 in the tying state, the pocket 16 can be protected from being pressed by an external force.

Further, in the tying state, the convex portions 18 are arranged on both outer sides of the pocket 16 in the left-right direction 7. Therefore, the gap between the first sheets 14 is likely to be maintained around the pocket 16. That is, even when the PTP sheet 10 is bent, the possibility that the pocket 16 comes into contact with the opposing PTP sheet 10 is reduced.

Further, since the pocket 16 and the convex portion 18 are arranged asymmetrically in the virtual straight lines V1 and V2, the PTP sheet 10 is tied together so that the front end 21 and the rear end 22 of the two PTP sheets 10 coincide with each other. If so, the opposing pockets 16 and the protrusions 18 do not come into contact with each other. That is, the two PTP sheets 10 can be put into a tying state without being displaced from each other in the front-rear direction 6. As a result, the tying state is stable, and at the same time, it is possible to contribute to space saving.

Further, in the tying state, since the convex portion 18 supports the facing PTP sheet 10, the seal 20 is maintained in a state where it does not come into contact with the facing first surface 14. Further, since the seal 20 is arranged at an asymmetrical position on the convex portion 18 and the virtual straight lines V1 and V2, the protruding end of the convex portion 18 comes into contact with the opposing PTP sheet 10 at a position different from that of the seal 20. Therefore, the seal 20 does not come into contact with the opposite convex portion 18. Therefore, it is possible to prevent the characters and patterns written on the sticker 20 from becoming hazy or blurred.

Further, since the range in which the PTP sheet 10 in the tying state can be relatively displaced in the left-right direction 7 and the front-rear direction 6 is limited, the tying state is further stabilized. In particular, even when a plurality of pairs of PTP sheets 10 in a tying state are laminated, they are less likely to collapse.

Further, since the PTP sheet 10 can be bent by using the slit 13 as a bending line, the patient can easily carry it. Further, even in the bent state, the pocket 16 is maintained in a state where it does not come into contact with the facing cell 12, so that the pocket 16 can be protected from being pressed by an external force.

[Modification example 1] In the above-described embodiment, the protruding end of the convex portion 18 is formed into a shape that is circular in a plan view and the central portion slightly bulges upward. On the other hand, the protruding end of the convex portion 18 may be molded into a flat shape parallel to the upper surface of the first sheet 14 in order to increase the area of contact with the facing first sheet 14. Alternatively, the protruding end of the convex portion 18 may have a ring shape having a recess 23 (an example of the recess of the present invention) in the center of the circle, as shown in FIGS. 5A and 5B. The convex portion 18 comes into contact with the first sheet 14 of the PTP sheet 10 facing along the ring. In such a protruding end shape, the force for supporting the PTP sheet 10 with which the convex portion 18 faces is received by the ring portion which is the peripheral edge portion of the recess 23. Since the peripheral portion of the recess 23 is less likely to be elastically deformed by the pressing force than the central portion, the PTP sheet 10 can be stably supported. In addition, since the recess 23 is formed at the protruding end of the convex portion 18, when the patient takes the drug 11, the pocket 16 in which the drug 11 is stored can be distinguished from the convex portion 18, which is more convenient. Can be improved.

[Modification 2] The arrangement of the pocket 16 and the convex portion 18 in the above-described embodiment is an example, and may be appropriately changed by those skilled in the art. In FIG. 6 (A), the convex portions 18L of the PTP sheet 10L are arranged at the two opposite corners of the cell 12L, respectively. The pocket 16H of the PTP sheet 10H is arranged between the convex portions 18L. Similarly, the convex portions 18H of the PTP sheet 10H are arranged at the two opposite corners of the cell 12H, respectively. A pocket 16L of PTP sheet 10L is arranged between the convex portions 18H. According to such an arrangement, the gap between the PTP sheets 10L and 10H is maintained at the four corners of the PTP sheets 10L and 10H in the tying state. Then, the pockets 16L and 16H are arranged diagonally.

[Modification 3] In FIG. 6 (B), the PTP sheets 10L and 10H have only one convex portion 18L and 18H, respectively. In the combined state of the PTP sheets 10L and 10H, the convex portions 18L and 18H are arranged along the front-rear direction 6. Pockets 16L and 16H are arranged between the convex portions 18L and 18H, respectively. That is, the convex portions 18L and 18H and the pockets 16L and 16H are arranged in a straight line. According to such an arrangement, the protrusions 18L, 18H maintain the gap between the PTP sheets 10L, 10H along the anteroposterior direction 6. Then, pockets 16L and 16H are arranged between the convex portions 18L and 18H, respectively.

[Modification example 4] Further, the pocket 16 and the convex portion 18 in each cell 12 may be arranged as shown in FIG. 7 (A). In the above-described embodiment, the pocket 16 and the convex portion 18 are arranged asymmetrically in the virtual straight lines V1 and V2. In this modification, the pocket 16 and the convex portion 18 are also asymmetrically arranged in the virtual straight line V3 along the center of the PTP sheet 10 in the left-right direction 7. That is, the pocket 16 and the convex portion 18 are both asymmetrically arranged in the virtual straight lines V1 to V3 shown in FIG. 7 (A).

According to the arrangement of the pocket 16 and the convex portion 18, as shown in FIG. 7 (B), the two PTP sheets 10L and 10H have the front end 21 (FIG. 2) and the rear end 22 (FIG. 2). Can be tying so that they match. Further, as shown in FIG. 7 (C), the two PTP sheets 10L and 10H can be put into a tying state so that the front ends 21 and the rear ends 22 coincide with each other.

In FIG. 7B, the PTP sheet 10L is in the state shown in FIG. 2, and the PTP sheet 10H is turned upside down so that the front-rear direction 6 is reversed from the state shown in FIG. Then, the PTP sheet 10H is put on the PTP sheet 10L. This state is similar to the embodiment described above. On the other hand, in FIG. 7C, the PTP sheet 10L is in the state shown in FIG. 2, and the PTP sheet 10H is turned upside down so that the left-right direction 7 is reversed from the state shown in FIG. Then, the PTP sheet 10H is put on the PTP sheet 10L.

As described above, in this modification, when the PTP sheets 10L and 10H are in a tying state so that the outer edges of the sheets overlap in the front-rear direction 6 and the left-right direction 7, both are inverted in the front-rear direction 6 ( Neither in FIG. 7 (B) nor in the case of being inverted in the left-right direction 7 (FIG. 7 (C)), the opposing pockets 16L and 16H and the convex portions 18L and 18H do not come into contact with each other.

In FIG. 7 (B), pockets 16L and 16H are arranged between the convex portions 18L and 18H separated in the front-rear direction 6, and in FIG. 7 (C), the convex portions separated in the left-right direction 7 Pockets 16L and 16H are arranged between 18L and 18H. That is, in any case, since the convex portions 18L and 18H are arranged on both outer sides of the pockets 16L and 16H, the gap between the PTP sheets 10L and 10H can be easily maintained around the pockets 16L and 16H, and the pockets. The possibility that 16L, 16H will come into contact with the opposing PTP sheets 10L, 10H is reduced.

[Other variants] In addition to those described above, the number and arrangement of the convex portions 18 for each cell 12 may be appropriately changed within the technical scope of the present invention. Similarly, the shapes of the pocket 11 and the convex portion 18 may be changed as appropriate. Further, the protruding end of the convex portion 18 does not have to be circular in a plan view, and may be rectangular, for example.

Further, in the above-described embodiment, the PTP sheet 10 shown in FIG. 2 has two cells 12 arranged along the front-rear direction 6, but three or more cells 12 may be arranged. .. Alternatively, a plurality of cells 12 may be arranged along the left-right direction 7, or a plurality of cells 12 may be arranged along the front-rear direction 6 and the left-right direction 7, respectively.

Further, the entry area of the present invention may be realized by a method different from the above-described embodiment. For example, the upper surface of the first sheet 14 may be coated with another chemical substance to form an entry area of the present invention, or the first sheet 14 may be sandblasted or embossed to form an entry of the present invention. Regions may be formed.

Further, ribs or the like that come into contact with the peripheral surfaces of the convex portions 18 facing each other in the tying state may protrude from the upper surface of the first sheet 14. As a result, the relative movement of the first sheet 14 in the front-rear direction 6 and the left-right direction 7 may be stopped.

10 PTP sheet 11 Drug 12 Cell (one division) 13 Slit (cut part) 14 1st sheet 15 2nd sheet 16 ... Pocket 17 Entry area 18 Convex part 20 Sticker (entry area) 23 dent L1 Distance (1st distance) L2 Distance (2nd distance)