Device for irradiating a tumor tissue

The present invention relates to a patient by means of an ion beam according to the independent claim of the present application.<u style="single">tumor</u>It relates to a device and a method for irradiating a tissue.

Recently developed ion beam devices and methods are deep, for example under European patent application 98 117 256.2.<u style="single">tumor</u>It is recognized that the irradiation accuracy is improved. With these devices and methods, the patient<u style="single">tumor</u>Targets such as are cut into layers of the same thickness, and these layers are then surfaced in a grid pattern by an ion beam.<u style="single">every</u>Is scanned. The ion beam provides a processing space related to emission from a fixed coordinate system, the spatial angle of the ion beam axis in a fixed processing space, or different spatial angles made possible by gantry means.

patient's<u style="single">tumor</u>In order to place the ion beam in its fixed coordinate system of the irradiation space, the patient is first placed in the correct required position in the coordinate system, the ion beam is accurately irradiated, scanned, and the volume of the ion beam actually irradiated and scanned. But of the patient<u style="single">tumor</u>Must be consistent with the planned target body of. In such known cases, what is further needed for the patient is to hold the patient in the required position during irradiation. Complex devices, such as individually made thermoplastic mask systems, adjust the patient with millimeter precision prior to irradiation and the patient by means of a mask during irradiation to hold the patient in the required position. It is used to stabilize and fix the patient in place. Using known devices and methods, eg head and neck<u style="single">tumor</u>, Close to the spine<u style="single">tumor</u>It is only possible to irradiate a spatially fixed target object, such as, thereby fixing only the head with suitable masking means, or the entire body mask stabilizes the spatial columnar body. To.

Until now, it has not been possible to irradiate a moving target object in a place such as the chest using such a method. For example, breathing movements result in a few centimeters of movement within the chest of the target object, resulting in impossibility of the required millimeter accuracy. Thus, at the same time, it is not possible to achieve millimeter precision fixation when internal movement results in movement of the target object in the centimeter range. In addition, the movement of the target object during beam scanning results in substantial dosing inhomogeneity.

If the ions of the ion beam have a constant energy for scanning the lattice pattern, which is relatively fast in the plane, it can follow the lateral movement of the target object in the centimeter range in time. , Accelerator, for example<u style="single">tumor</u>Energy cannot be changed fast enough to follow the movement of an object with respect to depth, such as breathing or heartbeat in the patient's chest.

The problem of the present invention is that of a patient by means of an ion beam.<u style="single">tumor</u>In providing devices and methods for irradiating tissue, ion beams can be applied to spatial and temporal changes, especially spatial and temporal periodic changes with respect to the depth perpendicular to the ion beam direction of the object of interest.

These issues are resolved by the subject matter of the independent claim. The features of the preferred embodiment are shown in the dependent claims.

<p>According to the present invention, a patient by ion beam means<u style="single">tumor</u>The device that irradiates the tissue<u style="single">tumor</u>Ion beam bias used for tissue slice and planar scanning<u style="single">Mukai</u>It has a device, a stepwise ion beam energy control device, and a depth direction scanning accelerator for the ion beam. In addition, the device has an ion-breaking device that fits the range of the ion beam and is used as a depth scanning adaptive device, faster and deeper than the energy control device of the accelerator. In addition, in the processing space<u style="single">tumor</u>In the case of temporal and positional movement of tissue<u style="single">tumor</u>When scanning tissue, the device has a movement detector in the processing space.<u style="single">tumor</u>Bias that detects temporal and positional changes in the organization and has control measures<u style="single">Mukai</u>Equipment and depth<u style="single">every</u>Control the scanning device to adjust the direction and range of the ion beam.</p><p>The apparatus of the present invention has an advantage that it can irradiate a moving patient's target object with the same accuracy as a fixed patient's immovable target object. For this purpose, the movement detector detects the movement of the patient during irradiation, whereby the irradiation point is adjusted by the control device. In principle, with this device, it is no longer necessary to first adjust the patient within fixed spatial coordinates with millimeter accuracy, because the actual initial position of the patient by the movement detector is processed. This is because it can be applied to the program and / or the corrected processing program.</p>

<p>As a preferred embodiment of the present invention, the device has two electromagnets and is biased by the means thereof.<u style="single">Mukai</u>The device is a surface<u style="single">every</u>Enables scanning. The electromagnet directs the ion beam in the X and Y directions orthogonal to the ion beam axis, that is, in the direction perpendicular to each other.<u style="single">deflection</u>However, it is relatively fast compared to the means by the method of the ion beam energy control device.<u style="single">tumor</u>Face<u style="single">every</u>Is given scanning. For that purpose, the electromagnet is controlled by a fast reaction output unit and a measuring device. These devices are in a processing space orthogonal to the ion beam axis.<u style="single">tumor</u>It can be used for adjustment and application in scanning when the tissue changes in time and position.</p><p>Also, in a preferred embodiment of the invention, the device has at least one accelerator, whereby the energy of the ion beam is regulated.<u style="single">tumor</u>Tissue slices<u style="single">every</u>To<u style="single">Shift the depth,</u>Irradiated<u style="single">To be</u>Can be done. This is<u style="single">tumor</u>Whole slice<u style="single">every</u>It also has the advantage that it is fully scanned and the range of the ion beam is adjusted from slice to slice by relaxing the energy of the ion beam. Only synchrotrons or synchrocyclotrons are used as accelerators for that purpose, allowing equal amounts of ions and equal energies to accelerate to higher energies in stages. Due to the complexity of the accelerator control function, the energy of the ion beam is in the irradiation space or<u style="single">tumor</u>Rapidly enough to the prescribed range of the body, or with the required accuracy<u style="single">tumor</u>It cannot be applied by automatically following the movement of the tissue or patient.</p><p>In a preferred embodiment of the invention, the depth<u style="single">every</u>The scanning adaptive device therefore has two wedge-shaped cross-section ion destruction plates, which cover and move the entire irradiation field of the ion beam.<u style="single">tumor</u>Fast depth of tissue<u style="single">every</u>It can be applied to scanning.</p><p>For that purpose, in a preferred embodiment of the invention, an ion breaking plate is provided on an electromagnetically actable passage. Due to these electromagnetically actable passages, the position of the wedge-type ion destruction plate can be changed within milliseconds, and therefore the length of the ion destruction passage provided in the overlapping area of the wedge-type ion destruction plate. It can be changed by the ion breaking plate. For that purpose, the wedge-type ion breaking plate overlaps in the entire irradiation field of the ion beam, and within that range, it can be applied to the positional and temporal changes of the moving target body regardless of its position.</p><p>As a preferred embodiment of the present invention, the ion breaking plate is provided on a linear motor. In such a linear motor, continuous and fine adjustment of ion destruction is the depth of the target body.<u style="single">every</u>It brings the benefit of enabling the application of scanning. The change of the position of the wedge type ion destruction plate by the linear motor is not only extremely precise position but also depth.<u style="single">every</u>It is possible to apply a very high reaction rate to the temporal change of the target body.</p><p>As a further aspect, cylinders containing water of various thicknesses are used in place of wedges. The cover of the cylinder is made of a transparent plate, for example two plexiglass or silica glass plates, and the upper plate moves at 2 to 4 times the speed of a linear motor. The side cover of the cylinder is in the shape of steel or rubber bellows. Water layers of various thicknesses are supported by a hydraulic system, and when the cylinder is pulled out, water is drawn into the cylinder, and when the cylinder is pressed, the water is drained, the operation stops, and the configuration becomes empty. Be prevented.</p><p>This aspect has the advantage of allowing thinner thicknesses than with wedges. For wedges, the minimum thickness is calculated as wedge tilt x field size (generally 5 cm). The minimum thickness for a cylinder arrangement is the thickness of the two covers (generally 1 cm). Its minimum thickness reduces beam scattering and improves beam quality. The cylinder arrangement is more precise than the lateral wedge configuration.</p><p>In a further aspect of the invention, the motion detector has at least two measuring sensors for two spatial angles with respect to the ion axis. The measurement sensor is<u style="single">tumor</u>Search for any location of markings on the body area of a patient with tissue. Such markings are made in the form of dots, dashes, or other geometrically absorbable luminescent colors, or illuminants, that can be clearly searched and measured by a measuring sensor.</p><p>In a further aspect of the invention, the measurement sensor is a precision video camera that works with an image evaluation unit. It should be measured accurately by that means<u style="single">tumor</u>Areas of the body in the vicinity, as well<u style="single">tumor</u>The temporal and positional movement of the position of is advantageously possible. A further aspect of the invention, in place of a movement detector that uses body surface marking and a precision video camera, is in the body.<u style="single">tumor</u>It has an X-ray system that directly detects the movement of. In the case of the movement detection system, two X-ray tubes are mounted in the beam direction orthogonal to the ion beam. The two X-ray tubes are further oriented at right angles. In addition, two sensitive x-ray enhancers are, in each case, mounted oppositely on the opposite side of the patient. The X-ray tube emits a short, low-power X-ray flash at a frequency, such as 20 Hz, to keep the application low. The connected X-ray image is recorded in the image enhancer and displayed several times. As a result, a bidirectional image sequence is obtained, and the dislocation of the target point Pi is determined in substantially real time with a delay of about 50 ms using appropriate methods and appropriate software. The embodiment has the benefit of providing more information about movement within the body from x-ray recordings, from external indications on the surface of the body, allowing for more detailed determination of dislocations of temporal and positional organs. is there.</p><p>mainly,<u style="single">tumor</u>Body irradiation is composed of image points, which are the planes of the grid.<u style="single">every</u>Slice-shaped, placed side by side with each other, the ion beam is transformed from scan point to scan point in the X and Y directions orthogonal to the beam axis. Although the ion energy of the ion beam can be constantly retained by the enhancer in question, the number of ions per object point is not constant over time. Nevertheless,<u style="single">tumor</u>An ionization chamber with rapid readout that monitors the intensity of the ion beam flow to provide an ion beam dose of equal magnitude to all object points in the tissue is a preferred embodiment of the invention, in the beam passage of the ion beam. It is provided as a transmission counter. Such a transparent counter<u style="single">tumor</u>The control unit that determines and connects the residence time of the ion beam at the point of irradiation of the body commutates the ion beam to the next body point as soon as the determined beam administration is achieved. as a result,<u style="single">tumor</u>Body slices with a grid pattern surface<u style="single">every</u>Allows you to scan in an advantageous way.</p><p>The ionization chamber is preferably a conversion device and depth.<u style="single">every</u>Depth with a water layer between scan adaptors, especially wedge-type breaking plates, or transparent plates<u style="single">every</u>It is provided between the scan adaptation device and only controls the ions within that range, but does not affect the ion administration.</p><p>Patient's by means of ion beam<u style="single">tumor</u>The tissue irradiation method consists of the following steps. Placing the patient in a device that fits the patient's contour to place the patient in the irradiation space; Of the patient's body<u style="single">tumor</u>Mark areas close to; Whether the temporal and positional changes of the mark are determined by the means of the mobile exploration device,<u style="single">tumor</u>To capture the X-ray image of the X-ray beam with two X-ray beams orthogonal to the ion beam in the direction perpendicular to each other; Using an ion beam converter and an ion beam energy controller<u style="single">tumor</u>Another depth to apply the range of the ion beam to the temporal and positional changes of the marking determined by the combined use of the motion detector and the ion beam converter while scanning the tissue.<u style="single">every</u>Adjusting the ion beam by means of a scan adaptor.</p><p>Using this method, a moving patient, like a fixed patient, is moving<u style="single">tumor</u>When irradiating the body<u style="single">tumor</u>Where it is beneficial for tissue to achieve similar accuracy in the millimeter range, even for regular movements up to a few centimeters, such as movements as a result of heartbeat or breathing. is there. In this method, the ion beam irradiation is continuous.<u style="single">tumor</u>Irradiation does not need to be delayed until a repetitive position is achieved, following changes in tissue location over time and position. Applicable to slow patient movements that occur on an irregular basis, depth<u style="single">every</u>Ion irradiation by application of adaptive device and conversion device is applied temporally and positionally. Irradiation work should be interrupted only in the case of sudden changes in position, such as coughing.</p><p>So far<u style="single">tumor</u>The method of the present invention has the advantage of significantly reducing the irradiation time for the patient as compared to the method in which irradiation is allowed only if achieved at the same location in the tissue. This is because the irradiation operation is not related to, for example, the patient's heartbeat or respiratory regularity.</p>

Further benefits and properties of the present invention are shown in detail below with reference to the accompanying drawings. FIG. 1 shows the chest of a patient according to an aspect of the present invention.<u style="single">tumor</u>The process of irradiating the tissue is shown graphically. FIG. 2 graphically shows an example of a movement detection device. FIG. 3 shows a comparison of the bodies near the scanning point, when they are fixed in position and time, that is, when they move with the static target body in position and voluntarily, that is, when they move. It shows the difference from the target body. FIG. 4 shows an example of the present invention of the patient's head.<u style="single">tumor</u>The process of tissue irradiation is shown graphically. FIG. 5 is a schematic representation of an ion destroyer by means of various volumes of water. FIG. 6 shows another example of the present invention of the patient's head.<u style="single">tumor</u>It is shown graphically as tissue irradiation.

FIG. 1 shows an aspect of the present invention in the chest 23 of patient 10.<u style="single">tumor</u>The process of irradiating the tissue 3 is shown in the figure. For this purpose, the device is equipped with an ion beam 2 and the ion beam is biased from the ion beam axis 15.<u style="single">Mukai</u>It is orthogonal to the ion beam axis 15 by the device 1, and more specifically, it is biased through the gap 24 of the electromagnet 13 in the X direction and through the gap 25 of the electromagnet 14 in the Y direction.<u style="single">Mukai</u>Will be done. The gaps are arranged at right angles to each other.

patient's<u style="single">tumor</u>Before colliding on the tissue, the ion beam further passes through the ion destroyers 11 and 12 electromagnetically driven in the direction of arrow R. The depth of the ion destroyer applies to the range of ion beam 2.<u style="single">every</u>Used as a scanning adaptive device, the depth is faster than the energy control device (not shown) by means in which the ion beam energy is controlled before entering the gaps 24 and 25 of the electromagnets 13 and 14.<u style="single">every</u>Has applicability.

Ion energy controller (not shown)<u style="single">tumor</u>Unstable depth of tissue 3<u style="single">every</u>Brings scanning; as a result of increased energy, slices in a stepwise way<u style="single">every</u>And face<u style="single">every</u>After scanning, the ion beam is deeper<u style="single">tumor</u>Penetrates into the tissue and eventually slices the ion beam<u style="single">every</u>, And faces<u style="single">every</u>Overall as a result of scanning<u style="single">tumor</u>The tissue is destroyed.

At that time, when the patient 10 moves to the place indicated by the broken line,<u style="single">tumor</u>The position of tissue 3 moves in the same way. In the case of static irradiation, the irradiation cannot follow the movement of the patient, and healthy tissue is irradiated and destroyed. To avoid this, the device of FIG.<u style="single">tumor</u>There is a movement detection device 7 that detects temporal and positional changes in the position of the tissue 3. In the aspect of the present invention, the movement detection device comprises the precision video cameras 21 and 22, and follows the movement of the marking on the body of the patient 10 with the detected change value of the marking.<u style="single">tumor</u>Contact the image evaluation device associated with temporal and spatial changes in the location of tissue 3.

The controller (not shown in FIG. 1) is in processing space 8.<u style="single">tumor</u>In the case of temporal and positional changes in organization 3<u style="single">tumor</u>When irradiating the tissue, both the conversion device 1 having the electromagnets 13 and 14 and the ion destruction devices 11 and 12 for adjusting the direction of the ion beam on the one hand and the ion beam range on the other hand are controlled. By using the device shown in Figure 1, more precise beam adaptation, i.e. improved clinical success, is achieved in the history of beam therapy for more than 100 years. A continuous improvement in precision was brought about by the use of this scanning system consisting of two electromagnets arranged perpendicular to each other through the gap between the magnets in which the ion beam is guided and converted. Using the device according to FIG. 1, the target body, that is,<u style="single">tumor</u>Tissue 3 is scanned with a fine beam of ions at varying intensities. The diameter of the ion beam can give ion administration in the millimeter range, and the accuracy is similar to the millimeter meter range.

In the case of movement of the target body 26 during irradiation, there is a discrepancy between the actual beam focus and the actual target, which results in improper irradiation within the target body 26, which leads to less than or greater than the local dose. .. The scanning method without the device of the invention according to FIG. 1 cannot be used in the case of the moving target body 26 these days.

Other irradiators are used that have a very high open beam flux as well as a very high degree of depth. Such an open beam bundle is a surface<u style="single">every</u>,slice<u style="single">every</u>It can cover all targets without scanning, and it is sliced by the force of a large radiation area.<u style="single">every</u>Non-uniform administration within the target body does not occur, as is the case when the scanning device is a mobile target body. In the case of a device with an open beam bundle, the movement of the organ has the effect of only the end and can be compensated by the enlargement of the irradiator so that the irradiator no longer remains in the target moving part. become. However, conversely, a large area of normal, healthy tissue at the edge of the target body must be similarly irradiated, and at the same time the accuracy is reduced when simultaneously moving the irradiated body using the open beam bundle. Increased negative side effects result in the patient.

Depth of the device in Figure 1<u style="single">every</u>When used without the scanning adaptor 5, organ movement can only be taken into account when the cross section of the ion beam 2 is substantially larger. However, solutions that somewhat reduce the accuracy of the lateral area and do not adjust the longitudinal dosing flanks do not allow the open beam to adjust the beam directional movement. Therefore, if an open beam is used to cover organ migration, the result is still a discrepancy distribution of internal targets in the beam direction.

depth<u style="single">every</u>The possibility of using the scanning adaptive device 5, and the device of Figure 1 which does not take into account the movement of organs, can include the detection of regular movements, eg, movement of the patient's chest with the help of movement detector 7, chest. Irradiation can be performed only when are in the same position. depth<u style="single">every</u>A device that does not have a scanning adaptive device and detects regular movements of the patient's chest can often increase irradiation and patient processing time. Because first of all<u style="single">tumor</u>This is because they have to wait in the same position. Only the open beam can reduce the processing time to the actual value in this case, which remains the same, leading to a lack of accuracy, as explained earlier.

Therefore, the apparatus according to the present invention proves that the depth of transmission of the ion beam is an approach by means that is optimally applied to the movement of the patient, and in the case of temporal and positional changes in position, in the case of temporal and positional changes.<u style="single">tumor</u>The tissue will be irradiated with extremely detailed millimeter accuracy.

FIG. 2 is a typical example of the movement detection device 7 according to a diagram. In this example, two precision video cameras 21, 22, confirm the movement of the body area of patient 10. The video camera detects the markings on the chest of patient 10 at two different spatial angles and sends them to the image evaluation unit (not shown). Marking 4, on the other hand, should be irradiated<u style="single">tumor</u>Arranged near the tissue, on the other hand, accurately captures the movement of the chest, from the temporal and positional changes of marking 4.<u style="single">tumor</u>It is possible to infer temporal and positional changes in the organization.

In a Cartesian coordinate system with the coordinate directions X, Y, and Z of the irradiation space 8, the space angles α and β change the space angle components αx, αy, and αz to the space angle β with respect to the space angle component α. On the other hand, the spatial angle component β_x, Β_yAnd β_zhave. The spatial angles α and β are clearly related to the coordinate systems X, Y and Z of the irradiation space 8 by these components. The first precision camcorder 21 in that array is Project Point A_α, B_αAnd C_αWith, project point A_αPasses through the plane consisting of the X and Z axes, and project point B_αPasses through the plane consisting of the Y and Z axes, and project point C_αPasses through a plane composed of the Z and Y axes. The second camera 22 is project point A_β, B_βAnd C_βWith, project point A_βPasses through the plane consisting of the X and Z axes, and project point B_βPasses through the plane consisting of the Y and Z axes, and project point C_βPasses through the plane constructed by the Z and Y axes. Through these project points, the positions of precision cameras 21 and 22 are similarly clearly defined within the illumination space 8 and the coordinates of the section angle α of the first precision video camera 21 are X._α, Y_αAnd Z_αAnd the coordinates of the spatial angle β in the case of the second precision video camera 22 are X._β, Y_βAnd Z_βIs.

The largest organ movement, i.e. the largest temporal and positional change in marking 4, occurs in the patient's chest during respiration. In the central chest 23, movements up to 1 cm in size and movements up to 3 cm at the tip of the lung appear. These movements as a result of breathing are periodic. The movement of internal structures is associated with the movement of the body surface. Optical monitoring and detection of the body surface by precision video cameras 21 and 22 provide the coordinates of their actual location with respect to the internal structure. For that purpose, markings 4 in the form of light emitters such as colored dashes, colored dots and light emitting diodes can be applied to the body surface. As a result, it is possible to grasp the internal shape of the patient at that time, the temporal transition of the movement of the internal structure, and the speed of the problem, without any intervention that harms the tissue.

Figure 3 shows scanning point P_iAnd P_{i + 1}P when fixed in place and time with the body near_{i + 1}It shows the comparison with. Therefore, the static target V_sDynamic target body V that moves in place and time_dIt shows the comparison with. The determination of the movement of the internal structure associated with the surface must be known prior to irradiation. It can be determined by model calculation or measurement.

Starting with an instantaneous measurement at time point t = 0, for a short recording similar to the grid scanning method for non-moving objects, the target is placed in a layer with a thickness with depth coordinates Z of the same particle range. Can be destroyed, each layer is an object scanning point P_i(x_i, y_i, z_i) Has a lateral network in the X and Y directions with control image points covering. During irradiation, those image points move to point P'_i(x_i+ Δx_i(t) y_i+ Δy_i(t) z_i+ Δz_iGo to (t)). Mismatch or migration Δx, Δy and Δz are obtained from the three-dimensional rate of organ migration over time Δt, which time is<u style="single">tumor</u>It is necessary for the administration of the object point P of the tissue (3). For example, the maximum movement of the chest 23 is 3 cm and the breathing frequency of about 0.5 Hz, that is, the maximum movement for 2 seconds is about V._organ = 3 cm / s speed of organ movement.

Image point P, which then becomes the body scanning point_iFor lateral and longitudinal scanning methods, take 1 to 3 mm intervals. That is, P_iNext nearby point P at a distance of 1 to 3 mm from the point irradiation administration_{i + 1}Approaching, beam administration is reintroduced to the body scanning point. Body scanning point P_iOr P_{i + 1}The administration time of is shorter than 10 ms. Therefore, the target point is 0.3 mm at the maximum in 10 ms, that is, the two object scanning points P._iAnd P_{i + 1}It will move a distance much shorter than the distance between and. Currently illuminated object scanning point P_iThe point Pi does not need to move during irradiation because the movement of is shorter than the lack of sensitivity of irradiation during irradiation. P_iAfter being irradiated, the beam is at point P_{i + 1}Must be sent to, point P'_{i + 1}Is moving from the originally planned point Pi + 1 due to the movement of organs. The movement of that organ is shown as r in Figure 3 and the velocity r = V_organ Derived from Δt. The (i +1) th actual point is; P'_{i + 1} = (X_{i + 1} + ΔX_{i + 1} (t), Y_{i + 1} + ΔY_{i + 1} (t), Z_{i + 1} + ΔZ_{i + 1} (t)). Object scan of moving point Pi Mismatch or transposition of scanning point Pi with the first static network results from movement within the irradiation time. In the case of normal repetitive or regular movements such as breathing, heart speed, etc., points such as these follow a cycle curve that can be associated with body surface movements. Parameterized display of movement with respect to time is possible. Patients with the apparatus of the present invention and the ion beam means of the present invention<u style="single">tumor</u>Tissue irradiation methods can be used to control non-repetitive processes only if the process of motion does not occur suddenly, but rather at a rate substantially slower than the scanning speed of the ion beam. For example, in the case of abrupt, busy movements that occur in cases such as coughing, the device must be able to be shut down with an emergency alert to protect healthy tissue from incorrect administration.

FIG. 4 illustrates an example of the present invention in the head 6 of patient 10.<u style="single">tumor</u>It is shown in the procedure of irradiation of tissue 3. The device of FIG. 4 is fully compatible with the device of FIG. 1 with ion beam 2 from axial 15<u style="single">deflection</u>It has two electromagnets 13 and 14 to make it, and the range of the ion beam is controlled by the wedge-shaped ion breaking plates 16 and 17. The overlap ranges 28 and 29, which cover at least the entire irradiation range, are due to the movement of the wedge-shaped fracture plates 16 and 17 in the direction of each other, which increases the destruction path of the ion beam 2 passing through the fracture plates 16 and 17. , The range of the ion beam is reduced. The opposite movements of the wedge-shaped fracture plate reduce the fracture path and increase the range of the ion beam. The directions of movement of the wedge-shaped fracture plates 16 and 17 are indicated by arrows R in FIG. The wedge-shaped outer shape and transposable fracture plate is driven by a high performance linear motor in this example, beam intensive, depth<u style="single">every</u>Adaptation can be achieved. Depth for linear drive<u style="single">every</u>The scanning adaptation device 5 is biased to the motion detection device 7.<u style="single">Mukai</u>It has an electronic control system that cooperates with device 1. In order to ensure a fast reaction, the protective plate of the linear motor that moves the destruction plates 16 and 17 on the movable table is air-mounted, and the motor current of the near motor is controlled by the means of servomotor control.

FIG. 5 is a representation of the ion destruction device 43 by various methods of water volume according to a diagram. Parts having the same functions as those in the above figure are indicated by the same reference numerals and are not described separately. Reference numeral 44 represents a layer of water placed between the transparent plates 31 and 32. Of the transparent plates 31 and 32, the plate 31 can be moved by the linear motors 34 and 35. The number of linear motors can be increased as desired in order to increase the moving speed of the plate 31. The water layer 44 is safely protected from lateral spills by Bellow 37. Depending on the direction of movement of the arrow directions G and F, a compensation tank 36 is provided to increase the volume of water or add water. The linear motors 34 and 35 hydraulically assist by injecting water when the water layer 44 increases and by extracting water when the thickness of the water layer 44 decreases. Reference numeral 33 indicates an intermediate space filled with water. The ion beam 2 must pass through the aqueous layer 44 for the purpose of destruction, and then through the transparent plates 31, 32, which can be made of glass or plexiglass. The smallest destruction can be achieved when the two plates 31, 32 are adjacent to each other. They are extremely thin thicknesses that minimize the scattering of ion beams.

Figure 6 shows the schematic of the patient's head.<u style="single">tumor</u>It is a further example of the present invention in the process of tissue irradiation. Parts having the same function in the above figure are indicated by the same number and will not be described separately.

In a further example different from the example of FIG. 4, the wedge system is not used as the ion destroyer 43, but rather as the ion destroyer 43 shown in FIG. Further examples of FIG. 6 differ from the examples of the systems of FIGS. 1 and 4 in which at least two X-ray tubes are used as motion detection systems. Measurement sensors 19 and 20 are X-ray tubes of patient 10.<u style="single">tumor</u>Manage X-ray beams 38 and 39 in tissue 3 at the correct angles to each other. These X-ray beams are, for example, by a low-power X-ray flash of 20 Hz.<u style="single">tumor</u>Directed to tissue 3 and received by the corresponding image enhancement plates or sensor plates 40, 41. The X-ray flash signals the evaluator 42. A motion detection system that uses an X-ray beam is inside the body.<u style="single">tumor</u>It can directly follow the movement of the body, thus allowing extremely tight control of the destruction device 43.

<p>Example 1 (first example of method execution) In Example 1 of the procedure performance, the surface of the patient is subjected to important markings such as color markings on the skin or light emitting diodes prior to irradiation. The patient is laid on a bed shaped to fit the patient's body with reference number 30, for example, as can be seen in FIGS. 1 and 4. In that way position accuracy of about 1 centimeter can be achieved without compulsion. At the irradiation position, as shown in FIGS. 1 and 4, patient 10 is monitored by at least two precision video cameras 21 and 22 from different spatial directions at spatial angles α and β. In the spatial direction, the position of marking 4 (compared to Fig. 2) is recorded as a function of time, and the image point or image scanning point P'_iIt provides a time-dependent correction function of (t). In order to achieve the three-dimensional rapid movement of the ion beam 2, a laterally controlled grid scanner consisting of two electromagnets 13 and 14 has a depth.<u style="single">every</u>Combined with scan adaptor 5. This is because, in the absence of the ion accelerator, the ion beam energy controller cannot bring about a rapid energy change during irradiation of body point P. The lateral scanning section, which consists of the two electromagnets described above and whose refraction directions are adjusted to be perpendicular to each other and to the beam axis 15, is controlled by a rapid power unit and rapid in the X and Y directions. Ensure lateral scanning adaptation.</p><p>An electromechanically driven depth consisting of two opposite wedges mounted in front of the patient, essentially on a linear motor, covering the entire illuminated surface, outside the scanning device in the X and Y directions.<u style="single">every</u>A scanning adaptation device is provided directly. Its depth<u style="single">every</u>The scanning adaptive device is the depth of the image point caused by the movement of the patient.<u style="single">every</u>It is used only to correct the position change of the patient's organ or the position change of the patient organ. Its depth<u style="single">every</u>The scanning adaptor does not have to cover the entire depth of the target.</p><p>depth<u style="single">every</u>In the middle of the fluctuation, the energy fluctuation of the synchrotron or other accelerator is used. In that method, beam flow is monitored by an ionization chamber in the beam path in front of the patient, from body scanning point Pi to the next Pi + 1 when the required particle dosing per body scanning point P is achieved. It will be switched. At the same time, precision video camera monitoring of the patient measures surface movement and then calculates movement of the target's internal structure.</p><p>side<u style="single">Mukai</u>Magnetic value of magnet and depth of wedge type breaking plate<u style="single">every</u>The applied value is modified based on the movement of the three-dimensional target body. The fact that the beam is undisturbed during irradiation in this type of method and device is at the same time<u style="single">tumor</u>It means that there is no place where the tissue is not irradiated. The accuracy of sharp wedges that deviate from internal and static irradiation achieves dynamic irradiation of mobile organs. Moreover, the devices and methods remain unchanged with respect to compression of body administration. In the case of body compression, for example in the chest, the image points come closer to each other. As a result, the influence of local particles increases. At the same time, the mass density also increases, resulting in compression. This is because administration is defined as a deposit of energy beyond density and is unaffected by compression to the first approximation. This means that in the case of the apparatus of the present invention and the method of the present invention, the movement of particles at individual beam positions does not need to be modified during irradiation.</p><p>Example 2 (second example of method execution) In Example 2 of method execution, instead of marking the patient's body<u style="single">tumor</u>Temporal and positional changes in tissue are confirmed directly by X-ray beams. For that purpose, after patient orientation, two X-ray beams<u style="single">tumor</u>Hit the organization. The X-ray beam is placed perpendicular to the ion beam 2 and a low power X-ray flash is given to keep the patient receiving low doses. These flashes have a frequency of 20Hz<u style="single">tumor</u>Can be directed at the organization. The X-ray beams are offset by 90 degrees from each other and placed at right angles to the ion beam 2. The X-ray beam flash emits an image enhancement plate and sends a signal to the evaluation unit 42 to control the destruction device 43. The breaking device 43 in Example 2 of the present invention is an aqueous layer 33, the thickness of which varies, and is placed between the transparent plates 31 and 32. The rapid change in water layer thickness is performed by changing the intermediate space 33 between the two transparent plates 31 and 32. The movement is carried out by linear motors 34, 35, as well as a compensating vessel 36, which provides pressure compensation and water volume compensation. Excluding that<u style="single">tumor</u>All irradiation means for treating the body follow the method of Example 1 already described.</p>

<figref num="1">Of the patient's chest, which is an aspect of the present invention<u style="single">tumor</u>The process of irradiating the tissue is shown graphically.</figref><figref num="2">An example of a movement detection device is shown graphically.</figref><figref num="3">It shows a comparison of the bodies near the scanning point, with the static target body when it is fixed in position and time, and the dynamic target body when it moves in position and voluntarily. It shows the difference between.</figref><figref num="4">An example of the present invention, of the patient's head<u style="single">tumor</u>The process of tissue irradiation is shown graphically.</figref><figref num="5">Schematic representations of ion-destroying devices by means of various volumes of water.</figref><figref num="6">Another example of the present invention, of the patient's head<u style="single">tumor</u>It is shown graphically as tissue irradiation.</figref>

1 Ion beam bias<u style="single">Mukai</u>apparatus 2 ion beam 3 <u style="single">tumor</u>Organization 4 marking 5 Depth scanning adaptor 6 head 7 Motion detector 8 processing room 9 Ion beam energy controller 10 patients 11,12 Ion destruction device 13 X direction electromagnet 14 Y direction electromagnet 15 Ion beam axis 16,17 Ion destruction plate 19,20 2 Measurement sensor 21,22 2 Precision camcorder 23 chest 24 Gap in electromagnet 13 25 Gap in electromagnet 14 26 Target body 27 Lung edge 28,29 Overlapping area 30 body bed 31,32 transparent plate 33 Intermediate space 34,35 linear motor 36 Compensation tank 37 Bellow 38,39 X-ray beam 40,41 Sensor board 42 Evaluation unit 43 Ion destruction device 44 water layer Vs static target Vd dynamic target PiP1 Body scanning point Body scanning point close to Pi + 1 Pi α, β spatial angle αx, αy, αz Part of the spatial angle α βx, βy, βz Part of spatial angle β Xα, Yα, Zα Coordinates of the spatial angle α of the first camera position Xβ, Yβ, Zβ Coordinates of the spatial angle β of the second camera position Aα, Bα, Cα Projection point on the plane XZ (Aα); YX (Bα); ZY (Cα) at the first camera position Aβ, Bβ, Cβ Projection point on the plane XZ (Aβ); YX (Bβ); ZY (Cβ) at the second camera position