Mitral valve spacer device
Abstract
The implantable prosthetic device may include a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member may be configured to be disposed between the natural valve leaflets of the heart. The anchor may be coupled to the spacer member and configured to secure the natural valve leaflet to the spacer member. The clasp may be attached to each anchor and configured to secure the natural valve leaflet to the anchor. The clasp may be allowed to move independently between the open and closed configurations.

Term
11.6 yearsto projected expiry
Projected expiry 10 May 2038, counted from filing; an application has no term until it is granted.
- Priority
- Filed
- Published
- Today
- Projected expiry
40 claims: 9 independent, 31 dependent
- 1心臓の自然弁尖の間に配設されるように構成されているスペーサー部材と、 前記スペーサー部材に結合され、前記自然弁尖を前記スペーサー部材に対して固定するように構成されている複数のアンカーと、 それぞれのアンカーに結合され、前記自然弁尖を前記アンカーに固定するように構成された複数のクラスプであって、開放構成と閉鎖構成との間で独立して移動可能である複数のクラスプと、 を含んでなることを特徴とする、植え込み可能な補綴デバイス。
- 2前記補綴デバイスは、前記スペーサー部材が半径方向に圧縮され、前記アンカーの少なくとも一部に関して軸方向に相隔てて並ぶ、圧縮構成と、前記スペーサー部材が前記圧縮構成に関して半径方向外向きに拡張し、前記アンカーの少なくとも一部と重なる、拡張構成との間で移動可能であることを特徴とする、請求項1に記載の補綴デバイス。
- 3前記アンカーは、第1の構成と第2の構成との間で前記スペーサー部材に関して枢動可能であり、前記アンカーの第1の部分と前記スペーサー部材との間に成す角度は、前記アンカーが前記第1の構成にあるときに約120度より大きいことを特徴とする、請求項1または2に記載の補綴デバイス。
- 4前記アンカーは、第1の部分と、第2の部分と、前記第1の部分と前記第2の部分との間に配設されるジョイント部分とを有し、前記第1の部分は、前記スペーサー部材に結合されていることを特徴とする、請求項1または2に記載の補綴デバイス。
- 5前記アンカーの前記少なくとも一部は、前記アンカーの第2の部分であることを特徴とする、請求項2に記載の補綴デバイス。
- 6前記第1の部分は、圧縮構成において前記第2の部分に関して隔てて並び、拡張構成において前記第2の部分と重なることを特徴とする、請求項4に記載の補綴デバイス。
- 7前記アンカーは、第1の構成と第2の構成との間で前記スペーサー部材に関して枢動可能であり、前記アンカーの第1の部分と前記スペーサー部材との間に成す角度は、前記アンカーが前記第1の構成にあるときに約180度であり、前記アンカーの前記第1の部分と前記スペーサー部材との間に成す前記角度は、前記アンカーが前記第2の構成にあるときに約0度であることを特徴とする、請求項1または2に記載の補綴デバイス。
- 8前記クラスプは取り付け部分とアーム部分とを備え、前記取り付け部分は前記アンカーに結合され、前記アーム部分は前記開放構成と前記閉鎖構成との間で前記取り付け部分に関して枢動可能であることを特徴とする、請求項1~7のいずれか一項に記載の補綴デバイス。
- 9前記クラスプは、前記取り付け部分と前記アーム部分との間に前記自然弁尖を捕らえるように構成されていることを特徴とする、請求項8に記載の補綴デバイス。
- 10前記クラスプは、前記閉鎖構成に付勢されるように構成されていることを特徴とする、請求項1~9のいずれか一項に記載の補綴デバイス。
- 11前記クラスプは、前記クラスプが前記閉鎖構成にあるときに予荷重を有するように構成されていることを特徴とする、請求項1~10のいずれか一項に記載の補綴デバイス。
- 12前記クラスプは、前記自然弁尖の組織と係合するように構成されているバーブを備えることを特徴とする、請求項1~11のいずれか一項に記載の補綴デバイス。
- 13前記スペーサー部材および前記アンカーは、単一の材料単位片から形成されることを特徴とする、請求項1~12のいずれか一項に記載の補綴デバイス。
- 14前記スペーサー部材および前記アンカーは、ニチノールを含む編組または織り材料を含むことを特徴とする、請求項1~13のいずれか一項に記載の補綴デバイス。
- 15前記補綴デバイスは、自然僧帽弁内に植え込むように、そして、僧帽弁逆流を低減するように構成されていることを特徴とする、請求項1~14のいずれか一項に記載の補綴デバイス。
- 16心臓の自然弁尖の間に配設されるように構成されているスペーサー部材と、 前記スペーサー部材に結合され、前記自然弁尖を前記スペーサー部材に対して固定するように構成されている複数のアンカーであって、第1の構成と第2の構成との間で前記スペーサー部材に関して枢動可能であり、前記アンカーが前記第1の構成にあるときに前記アンカーの少なくとも一部と前記スペーサー部材との間で成す角度が約180度で、前記アンカーが前記第2の構成にあるときに前記アンカーの前記少なくとも一部と前記スペーサー部材との間に成す前記角度が約0度である、複数のアンカーと、 それぞれのアンカーに結合され、前記自然弁尖を前記アンカーに固定するように構成された複数のクラスプであって、開放構成と閉鎖構成との間で独立して移動可能である複数のクラスプと、 を含んでなることを特徴とする、植え込み可能な補綴デバイス。
- 17前記アンカーは、第1の部分と、第2の部分と、前記第1の部分と前記第2の部分との間に配設されるジョイント部分とを有し、前記第1の部分は、前記スペーサー部材に結合され、前記アンカーの前記少なくとも一部は、前記アンカーの前記第1の部分であることを特徴とする、請求項16に記載の補綴デバイス。
- 18前記クラスプは、前記開放構成と前記閉鎖構成との間で別々に移動可能であることを特徴とする、請求項16または17に記載の補綴デバイス。
- 19スペーサー部材と、複数のアンカーと、複数のクラスプと、第1のカラーと、第2のカラーとを有する植え込み可能な補綴デバイスであって、前記アンカーの第1の端部分は、前記スペーサー部材の第1の端部分に結合され、前記アンカーの第2の端部分は、前記第1のカラーに結合され、前記第2のカラーは、前記スペーサー部材の第2の端部分に結合され、前記クラスプは、前記アンカーに結合されている、植え込み可能な補綴デバイスと、 第1のシャフトと、第2のシャフトと、複数のクラスプ制御部材とを有する送達装置であって、前記第1のシャフトは、前記補綴デバイスの前記第1のカラーに解放可能に結合され、前記第2のシャフトは、前記補綴デバイスの前記第2のカラーに解放可能に結合され、前記クラスプ制御部材は、前記補綴デバイスの前記クラスプに解放可能に結合され、前記クラスプ制御部材を作動させると、前記クラスプが開放構成と閉鎖構成との間で移動する、送達装置と、 を含んでなることを特徴とするアセンブリ。
- 20前記第1のシャフトおよび前記第2のシャフトを互いに関して移動させると、前記補綴デバイスが、アンカーが半径方向に圧縮され、軸方向に伸長する構成である、第1の構成と、前記アンカーが半径方向に拡張され、軸方向に圧縮される構成であって、前記アンカーと前記スペーサー部材との間で自然弁尖を捕らえるように前記スペーサー部材と少なくとも部分的に重なる、第2の構成との間で移動するように、前記送達装置が構成されていることを特徴とする、請求項19に記載のアセンブリ。
- 21前記送達装置は、クラスプ制御機構をさらに含み、前記クラスプ制御部材は、前記クラスプ制御機構に解放可能に結合され、前記クラスプ制御機構は、前記クラスプ制御部材が同時にまたは別々に、のいずれかで作動され得るように構成されていることを特徴とする、請求項19または20に記載のアセンブリ。
- 22前記クラスプ制御部材は、第1のクラスプ制御部材と第2のクラスプ制御部材とを備え、前記クラスプ制御機構は、第1の側部と、第2の側部と、前記第1の側部と前記第2の側部とを選択的に結合する取り外し可能ピンとを備え、前記第1のクラスプ制御部材は、前記クラスプ制御機構の前記第1の側部に解放可能に結合され、前記第2のクラスプ制御部材は、前記クラスプ制御機構の前記第2の側部に解放可能に結合されていることを特徴とする、請求項21に記載のアセンブリ。
- 23前記第1のシャフトおよび前記第2のシャフトに結合され、前記第1のシャフトと前記第2のシャフトとの間の相対的な軸方向移動を選択的に妨げるように構成されている係止機構を、前記送達装置がさらに備えることを特徴とする、請求項19~22のいずれか一項に記載のアセンブリ。
- 24前記係止機構は、回転可能ノブを備えることを特徴とする、請求項23に記載のアセンブリ。
- 25前記係止機構は、係止構成から解放構成に選択的に移動可能であるように構成され、前記係止機構は、前記係止構成において前記第1のシャフトと前記第2のシャフトとの間の相対的な軸方向移動を妨げ、前記係止機構は、前記解放構成において前記第1のシャフトと前記第2のシャフトとの間の相対的な軸方向移動を可能にすることを特徴とする、請求項23または24に記載のアセンブリ。
- 26前記係止機構は、ノブと、駆動ネジと、ガイドピンとを備え、前記ノブは、前記第2のシャフトおよび前記駆動ネジに回転可能に結合され、前記駆動ネジは、前記第1のシャフトに結合され、前記ガイドピンは、前記第2のシャフトに結合され、前記ノブと前記駆動ネジとの間の相対的な回転移動を妨げるように構成され、前記ノブを前記第2のシャフトおよび前記駆動ネジに関して回転させると、その結果、前記第1のシャフトと前記第2のシャフトとの間で相対的な軸方向移動が生じることを特徴とする、請求項23に記載のアセンブリ。
- 27前記第1のシャフトおよび前記第1のカラーは、螺合可能に結合されていることを特徴とする、請求項19~26のいずれか一項に記載のアセンブリ。
- 28前記第1のカラーは、内腔を備え、前記第1のシャフトは、前記第1のシャフトの遠位端部分に配設された半径方向拡張可能部分を備え、前記半径方向拡張可能部分は、前記半径方向拡張可能部分が圧縮状態にあるときに前記半径方向拡張部分が前記第1のカラーの前記内腔に挿通され得るように、また前記半径方向拡張可能部分が前記第1のカラーの前記内腔に挿通され、前記半径方向拡張可能部分が拡張状態にあるときに前記半径方向拡張部分が前記第1のカラーの前記内腔を通して引き抜けないように構成されていることを特徴とする、請求項19~26のいずれか一項に記載のアセンブリ。
- 29心臓の自然弁尖の間に配設されるように構成されているスペーサー部材と、 前記スペーサー部材に結合され、前記自然弁尖を前記スペーサー部材に対して固定するように構成されている複数のアンカーと、 前記自然弁尖を前記アンカーに固定し、固定された端部分および自由端部分を有するように構成されている複数のクラスプであって、前記固定された端部分は、前記アンカーに結合され、前記自由端部分はバーブを有し、前記自由端部分は、開放構成と閉鎖構成との間で前記固定された端部分に関して枢動可能であり、前記自由端部分は、前記バーブが前記自然弁尖の組織と係合する第1の位置から前記バーブが前記自然弁尖の前記組織から係脱する第2の位置まで前記開放構成で軸方向に移動可能である、複数のクラスプと、 を含んでなることを特徴とする、植え込み可能な補綴デバイス。
- 30心臓の自然僧帽弁尖の間に配設されるように構成されているスペーサー部材と、 前記スペーサー部材に結合される複数のアンカーであって、心室収縮期に前記自然僧帽弁尖を前記スペーサー部材に対して固定し、心室拡張期に前記自然僧帽弁尖が前記スペーサー部材から遠ざかることを許すように構成されている、複数のアンカーと、 それぞれの前記アンカーに結合され、自然弁尖を前記アンカーに固定するように構成されており、開放構成と閉鎖構成との間で移動可能である、複数のクラスプと、 を含んでなることを特徴とする、植え込み可能な補綴デバイス。
- 31心臓の自然弁尖の間に配設されるように構成されているスペーサー部材と、 前記スペーサー部材に結合され、前記スペーサー部材内に半径方向に配設されるスリーブと、 前記自然弁尖を前記スペーサー部材に対して固定し、第1の端部分および第2の端部分を有するように構成されている複数のアンカーであって、前記第1の端部分は、前記スペーサー部材に結合され、前記アンカーは、伸長構成と短縮構成との間で移動可能である、複数のアンカーと、 前記アンカーの前記第2の端部分に結合されるピストンと、 を含んでなり、前記ピストンは、第1の構成と第2の構成との間でシリンダーに関して軸方向に移動可能であり、前記アンカーは、前記ピストンが前記第1の構成にあるときに伸長構成を取り、前記アンカーは、前記ピストンが前記第2の構成にあるときに前記短縮構成を取ることを特徴とする、植え込み可能な補綴デバイス。
- 32第1の内腔と、前記第1の内腔から半径方向外向きに配設される複数の第2の内腔とを有する外側シャフトと、 前記第1の内腔を通って延在する作動シャフトであって、前記外側シャフトに関して軸方向に移動可能であり、前記補綴デバイスの前記ピストンに解放可能に結合される、作動シャフトと、 前記第2の内腔を通って延在し、前記補綴デバイスに解放可能に結合される複数のテザーであって、該テザーをピンと張ると、前記補綴デバイスおよび前記外側シャフトは互いの方へ移動し、該テザーを緩ませると、前記補綴デバイスおよび前記外側シャフトは互いから隔たるのを可能にする、複数のテザーと、 を含んでなる送達装置と、請求項31に記載の補綴デバイスとを含んでなることを特徴とするアセンブリ。
- 33前記テザーのそれぞれが、約180度だけ周上にオフセットされている2つの前記第2の内腔の中に配設されていることを特徴とする、請求項32に記載のアセンブリ。
- 34前記補綴デバイスは、複数のクラスプをさらに備え、前記クラスプがそれぞれのアンカーに結合され、前記自然弁尖を前記アンカーに固定するように構成されており、前記クラスプが開放構成と閉鎖構成との間で移動可能であり、 前記送達装置の前記外側シャフトは、前記第1の内腔から半径方向外向きに配設される複数の第3の内腔をさらに備え、 前記送達装置は、前記第3の内腔を通って延在し、前記補綴デバイスの前記クラスプに解放可能に結合される複数の制御部材をさらに備え、前記制御部材をピンと張ると、前記クラスプは前記開放構成に移動し、前記制御部材を緩ませると、前記クラスプは前記閉鎖構成に移動することを許されることを特徴とする、請求項32または33に記載のアセンブリ。
- 35前記制御部材は、約180度だけ周上にオフセットされている2つの前記第3の内腔の中に配設されていることを特徴とする、請求項34に記載のアセンブリ。
- 36前記第2の内腔のそれぞれは、約90度だけ隣接する第2の内腔に関して周上でオフセットされ、前記第3の内腔のそれぞれは、約90度だけ隣接する第3の内腔に関して周上でオフセットされ、前記第2の内腔のそれぞれは、約45度だけ隣接する第3の内腔に関して周上でオフセットされていることを特徴とする、請求項34または35に記載のアセンブリ。
- 37スペーサー部材と、複数のアンカーと、複数のクラスプと、第1のカラーと、第2のカラーとを有する植え込み可能な補綴デバイスであって、前記アンカーの第1の端部分は、前記スペーサー部材の第1の端部分に結合され、前記アンカーの第2の端部分は、前記第1のカラーに結合され、前記第2のカラーは、前記スペーサー部材の第2の端部分に結合され、前記クラスプは、前記アンカーに結合され、開放構成と閉鎖構成との間で独立して移動可能である、植え込み可能な補綴デバイスと、 第1のシャフトと、第2のシャフトと、複数のテザーと、複数のクラスプ制御部材とを有する送達装置であって、前記第1のシャフトは、前記テザーによって前記補綴デバイスの前記第1のカラーに解放可能に結合され、前記第2のシャフトは、前記補綴デバイスの前記第2のカラーに解放可能に結合され、前記クラスプ制御部材は、前記補綴デバイスの前記クラスプに解放可能に結合される、送達装置と、 を含んでなり、前記クラスプ制御部材を作動させると、前記クラスプが開放構成と閉鎖構成との間で移動し、 前記テザーをピンと張ると、前記補綴デバイスおよび前記第1のシャフトは互いの方へ移動し、前記テザーを緩ませると、前記補綴デバイスおよび前記第1のシャフトが互いから隔たることが可能になることを特徴とするアセンブリ。
- 38本体部と、 前記本体部に結合され、補綴スペーサーデバイスのアンカーに結合され、前記補綴スペーサーデバイスの前記アンカーを閉鎖構成と開放構成との間で移動するように構成されているアンカー作動機構であって、ノブと、第1の動作モードと第2の動作モードとの間で前記アンカー作動機構を移動するように構成されているモードセレクターボタンとを備えるアンカー作動機構と、 を含んでなる、送達装置のためのハンドルであって、 前記アンカー作動機構が前記第1の動作モードにあるときに、前記ノブは前記本体部に関して回転可能であり、前記ノブが回転すると、前記補綴スペーサーデバイスの前記アンカーが前記閉鎖構成と前記開放構成との間で移動し、 前記アンカー作動機構が前記第2の動作モードにあるときに、前記ノブは前記本体部に関して軸方向に摺動可能であり、前記ノブを軸方向に摺動させると、前記補綴スペーサーデバイスの前記アンカーが前記閉鎖構成と前記開放構成との間で移動することを特徴とする、送達装置のためのハンドル。
- 39前記本体部に結合されるクラスプ作動機構をさらに備え、前記クラスプ作動機構は、前記補綴スペーサーデバイスのクラスプに結合されるように構成され、前記補綴スペーサーデバイスの前記クラスプを閉鎖構成と開放構成との間で移動するように構成されていることを特徴とする、請求項38に記載のハンドル。
- 40送達装置のハンドルの第1の部分に解放可能に結合されるように構成されている本体部と、 前記本体部から延在する1つまたは複数の突出部であって、前記送達装置の前記ハンドルの第2の部分と解放可能に係合するように構成されている、1つまたは複数の突出部と、 を含んでなる、送達装置のための位置決めツールであって、 当該位置決めツールは、前記送達装置の前記ハンドルの前記第1の部分と前記第2の部分との間の相対的移動を、当該位置決めツールがそれに結合されるときに妨げることを特徴とする、送達装置のための位置決めツール。
Independent claims40
321 paragraphs, as filed
The present disclosure generally relates to prosthetic devices and related methods to help seal the natural heart valve to prevent or reduce regurgitation through it, as well as to implant such prosthetic devices. It concerns devices and related methods.
Natural heart valves (ie, aortic valves, pulmonary valves, tricuspid valves, and mitral valves) play an important role in ensuring an anterior flow of adequate supply of blood through the cardiovascular system. These heart valves can be damaged and thus diminished by congenital malformations, inflammatory processes, infectious diseases, infectious conditions, or diseases. Such damage to the valve can result in serious cardiovascular side effects or death. For years, the definitive treatment for such damaged valves has been surgical repair or replacement of the valves in cardiotomy. However, such cardiotomy surgery is highly invasive and tends to cause many complications. Therefore, elderly and frail patients with defective heart valves often remained untreated. Most recently, transvascular techniques have been developed to introduce and implant prosthetic devices in a manner that is significantly less invasive than cardiotomy. One particular transvascular technique used to access the natural mitral and aortic valves is the transseptal technique. Transseptal techniques involve inserting a catheter into the right femoral vein, advancing it up in the inferior vena cava, and delivering it into the right atrium. The septum is then punctured and a catheter is passed through the left atrium. Such transvascular techniques are becoming more popular due to their high success rate.
A healthy heart generally has a conical shape that tapers towards the lower apex. The heart consists of four chambers, including a left atrium, a right atrium, a left ventricle, and a right ventricle. The left and right sides of the heart are separated by a wall commonly referred to as the septum. The natural mitral valve of the human heart connects the left atrium to the left ventricle. The mitral valve has an anatomical structure that is very different from other natural heart valves. The mitral valve comprises a ring-shaped portion, which is a ring-shaped portion of the natural valve tissue surrounding the mitral valve opening, and a pair of cusps, or valve tips, that descend from the ring into the left ventricle and extend. The mitral valve annulus can form a "D" shape, an oval shape, or any other non-perfect circular cross-sectional shape with a major axis and a minor axis. The anterior leaflet is larger than the posterior leaflet and can generally form a "C" -shaped boundary between the abutting free edges of the valve leaflets when closed together.
When properly operated, the anterior and posterior leaflets together act as a one-way valve, allowing blood to flow only from the left atrium to the left ventricle. The left atrium receives oxygen-rich blood from the pulmonary veins. When the muscles of the left atrium contract and the left ventricle dilates (also known as "ventricular diastole" or "diastole"), the oxygen-rich blood collected in the left atrium enters the left ventricle. It flows in. When the muscles of the left ventricle relax and the muscles of the left ventricle contract (also called "systole" or "systole"), blood pressure in the left ventricle increases, and this increase is the two leaflets. To urge them together, thereby closing the one-way mitral valve, which prevents blood from flowing back into the left atrium and instead is expelled from the left ventricle through the aortic valve. Multiple fibrous cords, called chordae tendineae, anchor the leaflets to the papillary muscles in the left ventricle to prevent the two leaflets from pressure-escaping and folding back through the mitral annulus toward the left atrium.
Mitral regurgitation occurs when the natural mitral valve fails to close properly during systole of cardiac contraction and blood flows from the left ventricle into the left atrium. Mitral regurgitation is the most common form of valvular heart disease. Mitral regurgitation has different causes such as valve leaflet deviation, papillary muscle insufficiency, and / or mitral valve annulus elongation resulting from dilation of the left ventricle. Mitral regurgitation in the central part of the valve leaflet is called central jet mitral valve regurgitation, and mitral valve regurgitation closer to one commissure of the valve leaflet (ie, where the valve leaflets meet) is eccentric. It can be called jet mitral regurgitation.
Some conventional techniques for treating mitral regurgitation include directly stitching together pieces of the natural mitral valve leaflets (known as "Alfieri" sutures). Other conventional techniques include the use of leaflet clips such as MitraClip® that are clipped onto the junctional edge of the natural mitral valve leaflet and hold them together to mimic Alfieri sutures. Unfortunately, however, MitraClip® devices have many drawbacks. For example, fixing the valve leaflets directly to each other can apply excessive stress to the valve leaflets, which in turn can cause tearing and single leaflet detachment. In addition, MitraClip® devices have a relatively narrow profile that can capture only very small areas of the valve leaflet, forming stressed areas on the valve leaflet and, in some cases, the valve leaflet. Can be traumatized. Fastening the valve leaflets directly to each other also prevents the captive portion of the junctional margin from separating during ventricular diastole, which can impede antegrade blood flow through the mitral valve.
In addition, surgery to implant a MitraClip® device is relatively difficult and time consuming for many reasons. For example, it is difficult to properly position the device so that the clip member is behind the spontaneous valve leaflet, which moves during the cardiac cycle. In addition, when positioning or removing the MitraClip® device, the clip members can become entangled or caught on adjacent tissue, such as chordae tendineae. Removing the device from the intertwined tissue is difficult and can damage the tissue. Another drawback is that a single MitraClip® device typically does not adequately reduce mitral regurgitation as only a very small area of the leaflet is held together. As such, multiple devices, such as 2-4 devices, are typically required to adequately deal with reflux, increasing the complexity of the surgery and increasing the time of the surgery.
In addition, it is difficult to operate the distal end of the MitraClip® delivery system within the small enclosed space of the left atrium. For example, the MitraClip® delivery system does not allow independent positioning of implants in the anterior-posterior, up-down, and left-right directions. Due to the limitations of the MitraClip® delivery system, adjusting the delivery system in the left-right direction will, for example, change the vertical positioning of the implant. Therefore, positioning the implant in the desired position along the junction edge using the MitraClip® delivery system is difficult and / or time consuming.
Therefore, improved devices and methods for treating mitral regurgitation continue to be needed.
<p><patcit num="1"><text>US Provisional Application No. 62 / 555,240</text></patcit><patcit num="2"><text>U.S. Patent Application No. 2016/0331523</text></patcit><patcit num="3"><text>US Provisional Application No. 62 / 161,688</text></patcit><patcit num="4"><text>U.S. Patent Application No. 62 / 491,392</text></patcit><patcit num="5"><text>U.S. Patent Application Publication No. 2016/0158497</text></patcit><patcit num="6"><text>U.S. Patent Application No. 15 / 796,436</text></patcit></p>
<p> Described herein are embodiments of a prosthetic device primarily intended to be implanted in one of the mitral, aortic, tricuspid, or pulmonary valve regions of the human heart. , And further embodiments of devices and methods for implanting it. Prosthetic devices can be used to help restore and / or replace defective natural valves.</p><p> The implantable prosthetic device may include a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member may be configured to be disposed between the natural valve leaflets of the heart. The anchor may be coupled to the spacer member and configured to secure the natural valve leaflet to the spacer member. The clasp may be attached to each anchor and configured to secure the natural valve leaflet to the anchor. The clasp may be independently movable between the open and closed configurations.</p>
<p> In one typical embodiment, the implantable prosthetic device comprises a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member is configured to be disposed between the natural valve leaflets of the heart. The anchor is coupled to the spacer member and is configured to secure the natural valve leaflet to the spacer member. The clasp is attached to each anchor and is configured to secure the natural valve leaflet to the anchor. The clasp can move independently between the open and closed configurations.</p><p> In some embodiments, the prosthetic device has a compression configuration in which the spacer members are radially compressed and axially spaced apart with respect to at least a portion of the anchors, and the spacer members extend radially outward with respect to the compression configuration. And it is movable to and from the extended configuration, which overlaps at least part of the anchor.</p><p> In some embodiments, the anchor is pivotable with respect to the spacer member between the first and second configurations. The angle formed between the first portion of the anchor and the spacer member is greater than about 120 degrees when the anchor is in the first configuration.</p><p> In some embodiments, the anchor has a first portion, a second portion, and a joint portion disposed between the first and second portions. The first portion is coupled to the spacer member.</p><p> In some embodiments, at least a portion of the anchor is a second part of the anchor.</p><p> In some embodiments, the first portion is spaced apart with respect to the second portion in the compressed configuration and overlaps the second portion in the extended configuration.</p><p> In some embodiments, the anchor is pivotable with respect to the spacer member between the first and second configurations. The angle between the first part of the anchor and the spacer member is about 180 degrees when the anchor is in the first configuration, and the angle between the first part of the anchor and the spacer member is Approximately 0 degrees when the anchor is in the second configuration.</p><p> In some embodiments, the clasp comprises a mounting portion and an arm portion, the mounting portion is coupled to an anchor, and the arm portion is pivotable with respect to the mounting portion between the open and closed configurations.</p><p> In some embodiments, the clasp is configured to capture the natural valve leaflet between the attachment portion and the arm portion.</p><p> In some embodiments, the clasp is configured to be urged to a closed configuration.</p><p> In some embodiments, the clasp is configured to have a preload when the clasp is in a closed configuration.</p><p> In some embodiments, the clasp comprises a barb that is configured to engage the tissue of the spontaneous valve apex.</p><p> In some embodiments, the spacer member and anchor are formed from a single unit piece of material.</p><p> In some embodiments, the spacer member and anchor comprises a braided or woven material containing nitinol.</p><p> In some embodiments, the prosthetic device is configured to be implanted within the natural mitral valve and to reduce mitral regurgitation.</p><p> In another typical embodiment, the implantable prosthetic device comprises a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member is configured to be disposed between the natural valve leaflets of the heart. The anchor is coupled to the spacer member and is configured to secure the natural valve leaflet to the spacer member. The anchor is pivotable with respect to the spacer body between the first configuration and the second configuration. The angle between at least part of the anchor and the spacer member is about 180 degrees when the anchor is in the first configuration, and the angle between at least part of the anchor and the spacer member is the angle that the anchor makes. It is about 0 degrees when in the second configuration. The clasp is attached to each anchor and is configured to secure the natural valve leaflet to the anchor. The clasp can be moved between open and closed configurations.</p><p> In some embodiments, the anchor has a first portion, a second portion, and a joint portion disposed between the first and second portions. The first portion is coupled to the spacer member. At least part of the anchor is the first part of the anchor.</p><p> In some embodiments, the clasp can be moved separately between the open and closed configurations.</p><p> In another typical embodiment, the assembly comprises an implantable prosthetic device and a delivery device. The implantable prosthetic device has a spacer member, a plurality of anchors, a plurality of clasps, a first collar, and a second collar. The first end portion of the anchor is coupled to the first end portion of the spacer member and the second end portion of the anchor is coupled to the first collar. The second collar is attached to the second end portion of the spacer member and the clasp is attached to the anchor. The delivery device has a first shaft, a second shaft, and a plurality of clasp control members. The first shaft is releasably coupled to the first collar of the prosthetic device, the second shaft is releasably coupled to the second collar of the prosthetic device, and the clasp control member is releasably coupled to the clasp of the prosthetic device. Combined releasably. Activating the clasp control member causes the clasp to move between the open and closed configurations.</p><p> In some embodiments, the delivery device is configured such that when the first and second shafts are moved relative to each other, the prosthetic device is configured such that the anchors are radially compressed and axially extended. And a second configuration in which the anchor is radially extended and axially compressed and at least partially overlaps the spacer member so as to catch the natural valve leaflet between the anchor and the spacer member. It is configured to move between and.</p><p> In some embodiments, the delivery device further comprises a clasp control mechanism, the clasp control member being releasably coupled to the clasp control mechanism. The clasp control mechanism is configured such that the clasp control members can be operated either simultaneously or separately.</p><p> In some embodiments, the clasp control member comprises a first clasp control member and a second clasp control member. The clasp control mechanism includes a first side portion, a second side portion, and a removable pin that selectively connects the first side portion and the second side portion. The first clasp control member is releasably coupled to the first side of the clasp control mechanism and the second clasp control member is releasably coupled to the second side of the clasp control mechanism.</p><p> In some embodiments, the delivery device is coupled to the first and second shafts so as to selectively prevent relative axial movement between the first and second shafts. It further includes a locking mechanism that is configured.</p><p> In some embodiments, the locking mechanism comprises a rotatable knob.</p><p> In some embodiments, the locking mechanism is configured to be selectively movable from a locking configuration to an unlocking configuration. The locking mechanism prevents the relative axial movement between the first shaft and the second shaft in the locking configuration, and the locking mechanism is between the first shaft and the second shaft in the release configuration. Allows relative axial movement between.</p><p> In some embodiments, the locking mechanism comprises a knob, a driving screw, and a guide pin. The knob is rotatably coupled to the second shaft and the driving screw, the driving screw is coupled to the first shaft, the guide pin is coupled to the second shaft, relative to the knob and the driving screw. It is configured to prevent the rotational movement. Rotating the knob with respect to the second shaft and the driving screw results in a relative axial movement between the first shaft and the second shaft.</p><p> In some embodiments, the first shaft and the first collar are screwed together.</p><p> In some embodiments, the first collar comprises a lumen. The first shaft comprises a radially expandable member disposed at the distal end portion of the first shaft. The expandable member is expanded so that the expandable member can be inserted into the lumen of the first collar when the expandable member is in the compressed state, and the expandable member is inserted into the lumen of the first collar. It is configured to prevent the expandable member from pulling out of the lumen of the first collar when the expandable member is in the expanded state.</p><p> In another typical embodiment, the implantable prosthetic device comprises a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member is configured to be disposed between the natural valve leaflets of the heart. The anchor is coupled to the spacer member and is configured to secure the natural valve leaflet to the spacer member. The clasp is configured to secure the natural valve leaflet to the anchor and have a fixed end portion and a free end portion. The fixed end portion is attached to the anchor. The free end has a barb. The free end portion is pivotable with respect to the fixed end portion between the open and closed configurations. The free end portion is axially movable in an open configuration from a first position where the barb engages the tissue of the spontaneous valve leaflet to a second position where the barb engages the tissue of the natural valve leaflet.</p><p> In another typical embodiment, the implantable prosthetic device comprises a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member is configured to be disposed between the natural mitral valve leaflets of the heart. The anchor is coupled to the spacer member. The anchor is configured to secure the natural mitral valve leaflet to the spacer member during ventricular systole and allow the natural mitral valve leaflet to move away from the spacer member during ventricular diastole. The clasp is attached to each anchor and is configured to secure the natural valve leaflet to the anchor. The clasp can be moved between open and closed configurations.</p><p> In yet another representative embodiment, the implantable prosthetic device comprises a spacer member, a sleeve, a plurality of anchors, and a piston. The spacer member is configured to be disposed between the natural valve leaflets of the heart. The sleeve is coupled to the spacer member and is arranged radially within the spacer member. The anchor is configured to secure the natural valve leaflet to the spacer member and have a first end portion and a second end portion. The first end portion is coupled to the spacer member. The anchor is movable between the extended configuration and the shortened configuration. The piston is coupled to the second end portion of the anchor. The piston is axially movable with respect to the cylinder between the first configuration and the second configuration. The anchor takes an extended configuration when the piston is in the first configuration. The anchor takes a shortened configuration when the piston is in the second configuration.</p><p> In another typical embodiment, the assembly comprises a prosthetic device from the previous paragraph and a delivery device. The delivery device comprises an outer shaft, an actuating shaft, and a plurality of tethers. The outer shaft has a first lumen and a plurality of second lumens arranged radially outward from the first lumen. The actuating shaft extends through the first lumen. The actuating shaft is axially movable with respect to the outer shaft and is releasably coupled to the piston of the prosthetic device. The tether extends through the second lumen and is releasably attached to the prosthetic device. When the tether is taut, the implantable prosthetic device and outer shaft move towards each other. Loosening the tether allows the implantable prosthetic device and outer shaft to separate from each other.</p><p> In some embodiments, each of the tethers is placed in two of the second lumens that are offset upward by about 180 degrees.</p><p> In some embodiments, the prosthetic device further comprises a plurality of clasps. The clasp is attached to each anchor and is configured to secure the natural valve leaflet to the anchor. The clasp can be moved between open and closed configurations. The outer shaft of the delivery device further comprises a plurality of third lumens disposed radially outward from the first lumen. The delivery device further comprises a plurality of control members that extend through a third lumen and are releasably coupled to the clasp of the prosthetic device. When the control material is taut, the clasp moves to an open configuration. Loosening the control material allows the clasp to move into a closed configuration.</p><p> In some embodiments, each of the control members is disposed in two of a third lumen that is offset upward by about 180 degrees.</p><p> In some embodiments, each of the second lumens is offset circumferentially with respect to the adjacent second lumen by about 90 degrees. Each of the third lumens is offset circumferentially with respect to the adjacent third lumen by about 90 degrees. Each of the second lumens is offset circumferentially with respect to the adjacent third lumen by about 45 degrees.</p><p> In another typical embodiment, the assembly comprises an implantable prosthetic device and a delivery device. The implantable prosthetic device has a spacer member, a plurality of anchors, a plurality of clasps, a first collar, and a second collar. The first end portion of the anchor is coupled to the first end portion of the spacer member and the second end portion of the anchor is coupled to the first collar. The second collar is attached to the second end portion of the spacer member and the clasp is attached to the anchor and can move independently between the open and closed configurations. The delivery device has a first shaft, a second shaft, a plurality of tethers, and a plurality of clasp control members. The first shaft is releasably coupled to the first collar of the prosthetic device by the tether, the second shaft is releasably coupled to the second collar of the prosthetic device, and the clasp control member is of the prosthetic device. Releasably combined with the clasp. Activating the clasp control member causes the clasp to move between the open and closed configurations. When the tether is taut, the prosthetic device and the first shaft move towards each other, and when the tether is loosened, the prosthetic device and the first shaft are allowed to separate from each other.</p><p> In another typical embodiment, the handle for the delivery device comprises a body portion and an anchor actuating mechanism coupled to the body portion. The anchor actuating mechanism is coupled to the anchor of the prosthetic spacer device and is configured to move the anchor of the prosthetic spacer device between the closed and open configurations. The anchor actuating mechanism comprises a knob and a mode selector button configured to move the anchor actuating mechanism between a first mode of operation and a second mode of operation. When the anchor actuating mechanism is in the first mode of operation, the knob is rotatable with respect to the body, and when the knob rotates, the anchor of the prosthetic spacer device moves between the closed and open configurations. When the anchor actuating mechanism is in the second mode of operation, the knob is axially slidable with respect to the body, and when the knob is slid axially, the prosthetic spacer device anchors are in closed and open configurations. Move between.</p><p> In some embodiments, the handle further comprises a clasp actuating mechanism coupled to the body. The clasp actuating mechanism is configured to be coupled to the clasp of the prosthetic spacer device and to move the clasp of the prosthetic spacer device between the closed and open configurations.</p><p> In one typical embodiment, the positioning tool for the delivery device comprises a body and one or more protrusions. The body is configured to be releasably coupled to the first portion of the handle of the delivery device. The protrusion extends from the body and is configured to releasably engage a second portion of the handle of the delivery device. The positioning tool hinders the relative movement between the first and second parts of the handle of the delivery device when the positioning tool is coupled to it.</p><p> The various innovative techniques of the present disclosure may be used in combination or separately. This "Outline of the Invention" is provided to introduce a selection of simplified forms of concepts further described in "Modes for Carrying Out the Invention" below. This "Summary of the Invention" is not intended to identify key or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter. do not. The aforementioned and other objectives, features, and advantages of the present disclosure will become more apparent from the following detailed description, which proceeds with reference to the accompanying drawings.</p>
<figref num="1">It is a figure which shows an exemplary embodiment of the prosthetic spacer device which shows the 1st structure.</figref><figref num="2">It is a perspective view of the prosthetic spacer device of FIG. 1 which shows the 2nd configuration.</figref><figref num="3">It is a perspective view of the prosthetic spacer device of FIG. 1 which shows the 3rd structure.</figref><figref num="4">It is a top view of the clasp of the prosthetic spacer device of FIG. 1 which shows the 1st structure.</figref><figref num="5">It is a perspective view of the clasp of the prosthetic spacer device of FIG. 1 which shows the 2nd configuration.</figref><figref num="6">It is a figure which shows another exemplary embodiment of a prosthetic spacer device.</figref><figref num="7">It is a side view of the prosthetic spacer device of FIG.</figref><figref num="8">FIG. 7 is a side view of the prosthetic spacer device of FIG. 7, showing a cover mounted on top.</figref><figref num="9">It is a figure which shows another exemplary embodiment of a prosthetic spacer device.</figref><figref num="10">It is a figure which shows another exemplary embodiment of a prosthetic spacer device.</figref><figref num="11">FIG. 6 illustrates an exemplary embodiment of a delivery assembly comprising a prosthetic spacer device (shown as a partial cross-section) of FIG. 6 and a delivery device.</figref><figref num="12">FIG. 5 is a perspective view of the distal end portion of the delivery assembly of FIG. 11 showing a prosthetic spacer device that is releasably coupled to a delivery device.</figref><figref num="13">FIG. 5 is a perspective view of the distal end portion of the delivery assembly of FIG. 11 showing a prosthetic spacer device released from the delivery device.</figref><figref num="14">It is sectional drawing of the coupler of the delivery device of FIG.</figref><figref num="15">FIG. 11 is a perspective view of the delivery assembly of FIG. 11 in which the prosthetic spacer device is shown in partial cross-section and some components of the delivery device are shown in schematic.</figref><figref num="16">It is a top view of the shaft of the delivery device of FIG.</figref><figref num="17">It is a side view of the proximal end portion of the delivery device of FIG.</figref><figref num="18">FIG. 6 is a cross-sectional view of the proximal end portion of the delivery device of FIG. 11, cut along straight line 18-18 shown in FIG.</figref><figref num="19">It is an exploded view of the proximal end portion of the delivery device of FIG.</figref><figref num="20">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="21">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="22">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="23">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="24">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="25">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="26">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="27">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="28">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="29">FIG. 6 illustrates an exemplary procedure of the delivery assembly of FIG. 11 used to repair the natural mitral valve of the heart, which is partially shown.</figref><figref num="30">FIG. 5 illustrates another exemplary embodiment of a handle for the delivery device of FIG.</figref><figref num="31">It is an exploded view of the handle of FIG.</figref><figref num="32">FIG. 5 shows a coupler for the delivery assembly of FIG. 11 and other exemplary embodiments of the proximal collar, showing couplers that are releasably coupled to the proximal collar.</figref><figref num="33">FIG. 3 is a perspective view of the coupler and the proximal collar of FIG. 32 showing the coupler released from the proximal collar.</figref><figref num="34">FIG. 5 shows a distal collar for the delivery assembly of FIG. 11, showing a distal collar that is releasably coupled to the actuating shaft by a release wire, and another exemplary embodiment of the actuating shaft, and release wire.</figref><figref num="35">FIG. 3 is a perspective view of the distal collar, actuation shaft, and release wire of FIG. 32 showing the distal collar released from the actuating shaft and release wire.</figref><figref num="36">FIG. 11 shows the coupler, proximal collar, distal collar, and other exemplary embodiments of the actuating shaft of the delivery assembly of FIG.</figref><figref num="37">FIG. 36 is a perspective view of the coupler and proximal collar of FIG.</figref><figref num="38">It is a figure which shows another exemplary embodiment of the clasp control member of the delivery device of FIG.</figref><figref num="39">It is a detailed view of the clasp control member of FIG. 38 taken from the perspective view 39 shown in FIG. 38.</figref><figref num="40">FIG. 38 is a diagram illustrating an exemplary embodiment of a guide rail for the clasp control member of FIG. 38.</figref><figref num="41">FIG. 5 illustrates another exemplary embodiment of the shaft of the delivery device of FIG.</figref><figref num="42">It is a figure which shows another exemplary delivery assembly and its component.</figref><figref num="43">It is a figure which shows another exemplary delivery assembly and its component.</figref><figref num="44">It is a figure which shows another exemplary delivery assembly and its component.</figref><figref num="45">It is a figure which shows another exemplary delivery assembly and its component.</figref><figref num="46">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="47">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="48">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="49">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="50">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="51">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="52">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="53A">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="53B">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="54">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="55">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="56">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="57">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="58">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="59">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="60">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="61A">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="61B">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="61C">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="61D">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="62">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="63">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="64">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="65">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="66">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="67">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="68">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="69">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="70">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="71">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="72">FIG. 5 shows another exemplary handle for a delivery device and its components.</figref><figref num="73">FIG. 5 shows another exemplary handle for the delivery device and its components, and still illustrates an exemplary embodiment of the clasp positioning tool.</figref><figref num="74">FIG. 5 shows another exemplary handle for the delivery device and its components, and still illustrates an exemplary embodiment of the clasp positioning tool.</figref><figref num="75">FIG. 5 shows another exemplary handle for the delivery device and its components, and still illustrates an exemplary embodiment of the clasp positioning tool.</figref>
General Considerations For purposes of illustrating the present invention, some aspects, advantages, and novel features of embodiments of the present disclosure are described herein. The disclosed methods, devices, and systems should not be construed as limiting in any way. Instead, the present disclosure covers all novel, non-obvious features and embodiments of various disclosed embodiments, alone and in various combinations and partial combinations with each other. Methods, devices, and systems are not limited to specific embodiments or features or combinations thereof, and the disclosed embodiments have one or more specific advantages, or problems are resolved. Not what you want.
The behavior of some of the disclosed embodiments is described in a particular sequential order for convenience of presentation, but this method of description is in a particular language in which the particular order is defined below. It will be understood to include relocation unless required in. For example, the actions described sequentially can be rearranged or performed concurrently, as the case may be. Further, for simplicity, the accompanying drawings may not indicate the various ways in which the disclosed method can be used in conjunction with other methods. In addition, the description may use phrases such as "provide" or "achieve" to describe the disclosed method. These phrases are a high level abstraction of the actual action performed. The actual behavior corresponding to these phrases can vary depending on the particular implementation and is easily recognizable by one of ordinary skill in the art.
As used in this application and claims, the singular forms indicated by "a, an" and "the" include the plural unless the context clearly indicates otherwise. In addition, the phrase "include" means "comprise." Moreover, the phrase "bonded" generally means physically, mechanically, chemically, magnetically, and / or electrically bonded or coupled. Do not exclude the existence of intermediate elements between items that are combined or associated unless there is a specific antonym.
As used herein, the term "proximal" refers to the location, orientation, or portion of a device that is closer to the user and farther from the implantation site. As used herein, the term "distal" refers to the location, orientation, or portion of a device that is farther from the user and closer to the implantation site. So, for example, the proximal movement of the device is the movement of the device away from the implant site towards the user (eg, out of the patient's body), while the distal movement of the device is away from the user at the implantation site. The movement of the device towards (eg, into the patient's body). The terms "longitudinal" and "axial" refer to axes that extend proximally and distally, unless explicitly defined in other ways.
As used herein, the phrase "approximate" means a value listed and any value within 10% of the value listed. For example, "about 100 degrees" means any value from 90 to 110 degrees, including edge values.
Illustrative Embodiments Described herein are primarily intended to be implanted in one of the mitral, aortic, tricuspid, or pulmonary valve regions of the human heart. An embodiment of a prosthetic spacer device, as well as a device and method for implanting it. Prosthetic spacer devices can be used to help restore and / or replace defective natural valves.
The prosthetic spacer device comprises a spacer member and at least one anchor. In some embodiments, the prosthetic spacer device further comprises at least one clasp and at least one collar.
The spacer member may be configured to be positioned within the natural valve opening to fill the space between the improperly functioning natural valve leaflets that do not naturally fully join. As such, the spacer member helps form a more effective seal between the natural valve leaflets and prevents or minimizes regurgitation (eg, mitral regurgitation). The spacer member is impervious to blood and blocks the flow of blood that the spontaneous valve leaflets close and regurgitate around the sides of the spacer member (eg, blood that flows back into the left atrium during ventricular systole). Can be provided with a structure that allows.
The spacer member can have various shapes. In some embodiments, the spacer member can have an extension cylinder shape with a round cross-sectional shape. In other embodiments, the spacer member can have an oval cross-section, a crescent cross-section, or various other non-cylinder shapes.
Constructing a prosthetic spacer device with a spacer member can reduce the need to implant multiple prosthetic spacer devices in the patient to reduce regurgitation, for example, as compared to devices that clip natural valve leaflets directly to each other. ..
In some embodiments configured to be implanted in the natural mitral valve, the spacer member is placed in or adjacent to the left atrium of the heart, in the atrium or upper end, and in the left ventricle of the heart. Alternatively, it may have a ventricle or lower end located adjacently and an annular flank extending between the natural mitral valve leaflets.
The anchor may be configured to secure the prosthetic spacer device to one or more of the natural valve leaflets so that the spacer members are positioned between the natural valve leaflets. The anchor may be configured to be positioned behind the natural valve leaflet when implanted so that the natural valve leaflet is trapped between the anchor and the spacer member.
In some embodiments, the first end portion of the anchor may be attached to the lower end portion of the spacer member, and the second end portion of the anchor is disposed below the lower end portion of the spacer member. It may be attached to one collar. In some embodiments, the prosthetic spacer device can include a second collar that attaches to the upper end portion of the spacer member.
The first and / or second collar may be configured to releasably connect the prosthetic spacer device to the delivery device. In some embodiments, the first and second collars may be movable independently of each other.
In some embodiments, the clasp is attached to the anchor. The clasp can be configured to capture the natural valve leaflets and secure them to the anchor. In some embodiments, the prosthetic spacer device comprises a plurality of clasps. In some embodiments, the clasps can operate independently or separately with respect to each other and / or anchors.
1-5 show an exemplary embodiment of the prosthetic spacer device 100 and its components. Referring to FIG. 1, the prosthetic spacer device 100 includes a spacer member 102, a plurality of paddles or anchors 104 (eg, two of the illustrated embodiments), and a plurality of clasps 106 (eg, in the illustrated embodiments). Two), a first color 108, and a second color 110 can be provided. As best shown in FIG. 3, the first end portion 112 of the anchor 104 may be coupled to and extend from the first end portion 114 of the spacer member 102, the second of the anchor 104. The end portion 116 can be coupled to the first collar 108. The second collar 110 may be coupled to the second end portion 118 of the spacer member 102.
The spacer member 102 and the anchor 104 can be joined together in various ways. For example, as shown in the illustrated embodiments, the spacer member 102 and the anchor 104 may be joined together by integrally forming the spacer member 102 and the anchor 104 as a single, unit component. This can be done, for example, by forming the spacer member 102 and the anchor 104 from a braided or woven material, such as a braided or woven nitinol wire. In other embodiments, the spacer member 102 and the anchor 104 can be joined together by welding, fasteners, adhesives, and / or other means for bonding.
With reference to FIG. 2, the anchor 104 can include a first portion 120 and a second portion 122 separated by a joint portion 124. In this way, the anchor 104 says that the first part 120 resembles the upper part of the leg, the second part 122 resembles the lower part of the leg, and the joint part 124 resembles the knee part of the leg. It is constructed to resemble a leg in terms of points.
In some embodiments, the first portion 120 and the second portion 122 may be separate components that are joined together by a joint portion 124. For example, in one particular embodiment, the first portion 120 and the second portion 122 may be plates or shafts that are joined together by a cloth covering that acts as a joint portion 124, among others.
The anchor 104 axes the first collar 108 and thus the anchor 104 along a longitudinal axis extending between the first end 114 and the second end 118 of the spacer member 102 with respect to the spacer member 102. It can be configured to move between various configurations by moving in a direction. For example, the anchor 104 may be positioned in a straight, or substantially straight, or unfolded configuration by moving the first collar 108 away from the spacer member 102 so that the anchor 104 is taut. .. In a straight configuration, the joint portion 124 of the anchor 104 is adjacent to the longitudinal axis of the spacer member 102 (eg, similar to the configuration shown in FIG. 20).
From the straight configuration, the anchor 104 can be moved to a fully folded configuration (eg, FIG. 1) by moving the first collar 108 towards the spacer member 102. First, as the first collar 108 moves towards the spacer member 102, the anchor 104 bends at the joint portion 124, which joint portion 124 is in the longitudinal direction of the spacer member 102, as shown in FIGS. It moves radially outward with respect to the axis and axially towards the first end portion 114 of the spacer member 102. As the first collar 108 continues to move towards the spacer member 102, the joint portion 124 is radially inward with respect to the longitudinal axis of the spacer member 102 and of the spacer member 102, as shown in FIG. Move axially towards the second end portion 118.
In some embodiments, the angle formed between the first portion 120 of the anchor 104 and the spacer member 102 may be about 180 degrees when the anchor 104 is in a straight configuration (eg, FIG. 20). The angle formed between the first portion 120 of the anchor 104 and the spacer member 102 may be about 0 degrees when the anchor 104 is in a fully folded configuration. The anchor 104 is positioned in various partially folded configurations such that the angle formed between the first portion 120 of the anchor 104 and the spacer member 102 can be approximately 10-170 degrees or approximately 45-135 degrees. Can be done.
There may be several advantages to configuring the prosthetic spacer device 100 so that the anchor 104 can extend in a straight or nearly straight configuration (eg, about 120-180 degrees with respect to the spacer member 102). For example, it can reduce the radial crimp profile of the prosthetic spacer device 100. This can also make it easier to catch the natural valve leaflets by forming a larger opening that catches the natural valve leaflets. In addition, the relatively narrow, straight configuration allows the prosthetic spacer device 100 to be entangled within the natural anatomy (eg, chordae tendineae) when positioning and / or removing the prosthetic spacer device 100 within the delivery device. This can be prevented or reduced.
Again, referring to FIG. 2, the clasp 106 can include a mounting portion 126 and an arm portion 128. The attachment portion 126 can be attached to the first portion 120 of the anchor 104 in a variety of ways, including sutures, adhesives, fasteners (eg, plate 129), welds, and / or means for joining.
The arm portion 128 can be pivoted with respect to the attachment portion 126 between the open configuration (eg, FIG. 2) and the closed configuration (FIGS. 1 and 3). In some embodiments, the clasp 106 can be urged into a closed configuration. In the open configuration, the attachment portion 126 and the arm portion 128 are pivotally moved away from each other so that the natural valve leaflets can be positioned between the attachment portion 126 and the arm portion 128. In the closed configuration, the attachment portion 126 and the arm portion 128 pivot toward each other, thereby clamping the natural valve leaflet between the attachment portion 126 and the arm portion 128.
Referring to FIGS. 4-5, each attachment 126 (only one shown in FIGS. 4-5) comprises one or more openings 130 (eg, three in the illustrated embodiment). be able to. At least some of the openings 130 can be used to connect the attachment portion 126 to the anchor 104. For example, sutures and / or fasteners can extend through the opening 130 of the clasp 106 and also through the anchor 104 to secure the attachment portion 126 to the anchor 104.
Each of the arm portions 128 can include two side beams 132 that are spaced apart to form a slot 134. Slot 134 may be configured to receive mounting portions 126. The arm portion 128 may further include a fixed end portion 136 coupled to the mounting portion 126 and a free end portion 138 disposed to face the fixed end portion 136.
The free end portion 138 of each arm portion 128 may comprise a gripping element such as a barb 140 and / or other means for frictionally engaging with the natural valve leaflet tissue. The gripping element may be configured to engage and / or penetrate the natural valve leaflet tissue to help hold the natural valve leaflet between the attachment portion 126 and the arm portion 128 of the clasp 106.
The free end portion 138 can also be provided with a small hole or opening 142 in order to connect the free end portion 138 to an actuating mechanism configured to pivot the arm portion 128 with respect to the mounting portion 126. Can be used. Further details regarding the coupling of the clasp 106 to the actuating mechanism are presented below.
In some embodiments, the clasp 106 can be formed from a shape memory material such as nitinol, stainless steel, and / or shape memory polymers. In some embodiments, the clasp 106 is formed by laser cutting a flat sheet piece of material (eg, nitinol) into the configuration shown in FIG. 4 and then shaping the clasp 106 into the configuration shown in FIG. Can be.
Fixing the shape of the clasp 106 in this way can provide several advantages. For example, the clasp 106 can be compressed from a fixed shape configuration (eg, FIG. 5) to a flat configuration (eg, FIG. 4) that shortens the radial crimp outer shape of the clasp 106. It also causes the barb 140 to radial inward towards the anchor 140 when the prosthetic spacer device 100 is advanced and passed through or removed from the catheter shaft (eg, see FIG. 20). It also improves the ability to track and retrieve the prosthetic spacer device 100 with respect to the catheter shaft of the delivery device. This thus prevents the clasp 106 from catching or tearing the catheter shaft, or reduces its likelihood.
In addition, by fixing the shape of the clasp 106 in the configuration shown in FIG. 5, the clamping force of the clasp 106 can be increased when the clasp 106 is in the closed configuration. This can be achieved when the clasp 106 is attached to the anchor 104 (eg, FIG. 3) because the arm portion 128 prevents further movement of the arm portion 128 towards the fixed shape configuration. This is because the shape is fixed with respect to the attachment portion 126 to the first position beyond the position (eg, FIG. 5). As a result, the arm portion 128 has a preload (ie, the clamping force is greater than zero) when the clasp 106 is attached to the anchor 104 and is in the closed configuration. Therefore, by fixing the shape of the clasp 106 in the configuration of FIG. 5, the clamping force of the clasp 106 can be increased as compared with the clasp whose shape is fixed in the closed configuration. In this way, the connection between the arm portion 128 and the mounting portion 126 functions as a spring hinge, urging the arm portion 128 into a closed configuration.
The magnitude of the preload of the clasp 106 can be changed by adjusting the angle at which the arm portion 128 is shaped and fixed with respect to the mounting portion 126. For example, increasing the relative angle between the arm portion 128 and the mounting portion 126 increases the preload, and decreasing the relative angle between the arm portion 128 and the mounting portion 126 decreases the preload. Other techniques and mechanisms, such as by coupling a spring (eg, torsion spring) or another type of urging element between the arm portion 128 and the mounting portion 126 to urge the clasp 106 to the closed position. Can be used. Alternatively, the clasp 106 may be connected to the corresponding anchor 104 without the attachment portion 126, and the urging element can be used to urge the clasp 106 to the anchor in a closed configuration.
In some embodiments, the second collar 110 and / or the spacer member 102 is configured to reduce or prevent blood from flowing through the second collar 110 and / or the spacer member 102. A hemostatic sealing member 144 can be provided. For example, in some embodiments, the sealing member 144 may include a plurality of flexible flaps 146, as shown in FIG. The flap 146 may be configured to pivot from a sealed configuration to an open configuration to allow the delivery device to extend through the second collar 110. The flap 146 may be configured to return from the open configuration to the sealed configuration when the delivery device is removed.
6-8 show an exemplary embodiment of the prosthetic spacer device 200. The prosthetic spacer device 200 has a spacer member 202, a plurality of anchors 204, a plurality of clasps 206, a first or distal collar 208, and a second or proximal collar 210. These components of the prosthetic spacer device 200 may be configured to substantially resemble the corresponding components of the prosthetic spacer device 100.
The prosthetic spacer device 200 may also include a plurality of anchor extension members 212. Each of the anchor extension members 212 has a first or fixed end portion 214 that is coupled to and extends from the distal collar 208 and a second or free portion that is disposed opposite the fixed end portion 214. It can be configured as a loop-shaped structure with an end portion 216. The anchor extension member 212 may be configured to extend farther than the anchor 204 over the circumference of the spacer member 202. For example, in some embodiments, each of the anchor extension members 212 may extend about about half the circumference of the spacer member 202 (as best shown in FIG. 7), and the anchor 204 may be the spacer member. It may extend to less than half of the circumference of 202 (as best shown in Figure 6). The anchor extension member 212 may also be configured to extend laterally beyond the outer diameter of the spacer member 202 (ie, perpendicular to the longitudinal axis of the spacer member 202).
In the anchor extension member 212, the free end portion 216 of the anchor extension member 212 is adjacent to the joint portion 218 of the anchor 204 in the axial direction when the prosthetic spacer device 200 is in the folded configuration (for example, FIGS. And may be further configured to be radially disposed between the first portion 220 and the second portion 222 of the anchor 204.
Constructing the anchor extension member 212 in this way provides a large surface area as compared to the anchor 204 alone. This can make it easier, for example, to capture and secure the natural valve leaflets. The increased surface area can also disperse the clamping force of the anchor 204 and the anchor extension member 212 on the natural valve leaflet over a relatively large surface of the natural valve leaflet to further protect the natural valve leaflet tissue.
The increased surface area of the anchor extension member 212 also causes the unclamped portion of the natural valve apex to face the spacer member 202 and join together at a position adjacent to the prosthetic spacer device 200. It can be made possible for the apex to be clamped to the prosthetic spacer device 200. This can, for example, improve the sealing of the spontaneous valve leaflets, thereby preventing or further reducing mitral regurgitation.
With reference to FIG. 8, the prosthetic spacer device 200 may also include a cover 224. In some embodiments, the cover 224 may be disposed on the spacer member 202, the anchor 204, and / or the anchor extension member 212. The cover 224 may be configured to prevent or reduce blood flow through the prosthetic spacer member 200 and / or promote internal tissue growth. In some embodiments, the cover 224 may be a cloth or woven fabric such as PET, velor, or other suitable fiber. In other embodiments, instead of or in addition to the woven fabric, the cover 224 may include a coating (eg, a polymer) applied to the prosthetic spacer device 200. Note that the prosthetic spacer device 200 is illustrated with cover 224 in FIGS. 6-7 and 12-13 and with cover 224 in 8, 11, and 27. In some embodiments, the cover 224 allows blood to flow through the spacer member 202 over a predetermined length of time (eg, a day or days, weeks, or months). It can have a selected porosity. As the spacer device becomes endothelialized over time, the amount of blood flow backflowing through the spacer member slowly and gradually decreases, which can reduce the amount of stress on the left ventricle after implantation. Further details of the cover allowing blood flow backflow through the spacer member over a predetermined period of time are disclosed in US Provisional Application No. 62 / 555,240, filed September 7, 2017, which is incorporated herein by reference. To.
FIG. 9 illustrates an exemplary embodiment of a prosthetic spacer device 300 comprising an annular spacer member 302, a woven cover (not shown) covering the outer surface of the spacer member 302, and an anchor 304 extending from the spacer member 302. Shown. A cover or additional cover may also extend over the anchor 304. The ends of each anchor 304 may be attached to the respective struts of the spacer member 302 by the respective sleeves 306 that may be crimped around the ends of the anchor 304 and the struts of the spacer member 302. One or more barbs or protrusions 308 may be mounted on the frame of the spacer member 302. The free end of the protrusion 308 may include a variety of shapes, including round, pointed, spiny and the like. The protrusion 308 is shaped to push the natural valve leaflet inward into the spacer member 302 within the region below the free end of the anchor 304, allowing the anchor 304 to exert a holding force on the natural valve leaflet. it can.
FIG. 10 shows an exemplary embodiment of the prosthetic spacer device 400. The prosthetic spacer device 400 can include an annular spacer member 402, a woven cover (not shown) covering the spacer member, and an anchor 404 extending from the spacer member 402, and has a configuration similar to that of the prosthetic spacer device 300. It can be taken. The cover may also cover the outer surface of the anchor.
The anchor 404 of the prosthetic spacer device 400 may be configured to resemble the anchor 304 of the prosthetic spacer device 300, except that the curve at the free end of each anchor 404 is wider than the anchor 304 and has a larger radius. As such, the anchor 404 covers a relatively large portion of the spacer member 402 as compared to the anchor 304. This can, for example, disperse the clamping force of the anchor 404 against the natural valve leaflets over a relatively large surface of the natural valve leaflets to further protect the natural valve leaflets. Also, the natural valve leaflets are clamped to the prosthetic spacer device 400 so that they are joined together at a position adjacent to the prosthetic spacer device 400 so that the natural valve leaflets face the spacer member 402, thus improving the sealing. be able to.
Further, one or a plurality of barbs or protrusions 406 may be mounted on the frame of the spacer member 402. The free end of the protrusion 406 can be provided with a stopper 408 configured to limit the range of the protrusion 406 that can engage and / or penetrate the natural valve leaflet.
Additional details regarding the prosthetic spacer device can be found, for example, in US Patent Application 2016/0331523 and US Provisional Application 62 / 161,688, which are incorporated herein by reference.
Prosthetic spacer devices (eg, devices 100, 200, 300, 400) can be coupled to the delivery device to form a delivery assembly. The delivery device can be used to percutaneously deliver, position, and / or immobilize the prosthetic spacer device into the patient's natural heart valve region.
11-27 show an exemplary delivery assembly 500 and its components. With reference to FIG. 11, the delivery assembly 500 may include a prosthetic spacer device 200 and a delivery device 502. The delivery device 502 may include a plurality of catheters and one or more catheter stabilizers. For example, in an exemplary embodiment, the delivery device 502 comprises a first catheter 504, a second catheter 506, a third catheter 508, and a catheter stabilizer 510. The second catheter 506 extends coaxially through the first catheter 504, and the third catheter 508 extends coaxially through the first catheter 504 and the second catheter 506. The prosthetic spacer device 200 may be releasably coupled to the distal end portion of the third catheter 508 of delivery device 502, as further described below.
Each of the catheter stabilizers 510 can be used to hold the corresponding catheter stationary with respect to the patient and other components of the delivery device during the procedure. The stabilizer 510 may be positioned on a common table or support platform, which may then be placed on the operating table. For example, after manually inserting the catheter into the patient's vasculature and positioning the distal end of the catheter in the desired position within the patient, the doctor then places the catheter in the corresponding stabilizer 510 for the procedure. The doctor's hand can be released so that another catheter can be operated during the run. Further details regarding the catheter stabilizer and the support platform for supporting the stabilizer are disclosed in US Patent Application No. 62 / 491,392, filed April 28, 2017, which is incorporated herein by reference.
In an exemplary embodiment, the delivery assembly 500 is configured to implant the prosthetic spacer device 200 into the natural mitral valve, for example, via a transseptal delivery approach. In other embodiments, the delivery assembly 500 may be configured to implant the prosthetic spacer device 200 within the aortic, tricuspid, or pulmonary valve region of the human heart. Also, the delivery assembly 500 can be configured for a variety of delivery methods, including transseptum, transaorta, transvascular, and the like.
With reference to FIG. 13, the first or distal collar 208 of the prosthetic spacer device 200 may include a bore 226. In some embodiments, the bore 226 comprises a female thread configured to releasably engage the corresponding male thread of the actuating shaft 512 of the delivery device 502, as best shown in FIG. be able to.
With reference to FIG. 13 again, the second or proximal collar 210 of the prosthetic spacer device 200 can include a central opening 228 that is axially aligned with the bore 226 of the distal collar 208. The central opening 228 of the proximal collar 210 may be configured to slidably receive the actuating shaft 512 of the delivery device 502, as best shown in FIG. In some embodiments, the proximal collar 210 and / or the spacer member 202 is configured to seal the central opening 228 as the actuating shaft 512 is pulled out of the central opening 228. Although not shown, however, they can have, for example, the sealing member 144 shown in FIG.
As best shown in FIG. 13, the proximal collar 210 can also include a plurality of ridges or protrusions 230 and a plurality of guide openings 232 formed within the protrusions 230. The protrusion 230 extends radially outward and can be offset (eg, 90 degrees) around the circumference with respect to the guide opening 232. The guide opening 232 may be arranged radially outward from the central opening 228. The protrusion 230 and the guide opening 232 of the proximal collar 210 may be configured to releasably engage the coupler 514 of the delivery device 502, as shown in FIG.
With reference to FIG. 11 again, as mentioned above, the delivery device 502 can include a first catheter 504 and a second catheter 506. The first catheter 504 and the second catheter 506 are, for example, to approach the implantation arrangement (eg, the natural mitral valve region of the heart) and / or to position the third catheter 508 at the implantation arrangement. Can be used.
The first catheter 504 and the second catheter 506 can include a first sheath or shaft 516 and a second sheath or shaft 518 extending from handles 517, 519, respectively. The first catheter 504 and the second catheter 506 can be configured such that the sheaths 516, 518 are maneuverable. For example, although not shown, the second catheter 506 has one or more pullwires and one or more flexible, axially incompressible pullwire sleeves (eg, spiral coils). And can be provided. The pullwire and sleeve can extend through a portion of the shaft 518, and the sleeve can move freely with respect to the shaft 518, which is incorporated herein by reference in U.S. Patent Application Publication No. 1. As further explained in 2016/0158497. This is, for example, with respect to the distal end portion of the implantable catheter (eg, third catheter 508) and therefore the prosthesis spacer device in one or more other directions (eg, downward / upward) with respect to the mitral valve. The steerable distal end portion 518a of the shaft 518 is in one or more directions (eg, the junction between the natural mitral valve leaflets between the posterior medial and anterior lateral commissures, while keeping further coaxial. It can be allowed to be deflected, moved, and / or rotated (inward / outward and / or anterior / posterior) following a "C" shape.
Additional details regarding the first catheter 504 can be found, for example, in US Patent Application No. 15 / 796,436, filed October 27, 2017, which is incorporated herein by reference. Additional details regarding the second catheter 506 can be found, for example, in US Patent Application Publication No. 2016/0158497.
Still referring to FIG. 11, delivery device 502 can also include a third catheter 508, as described above. The third catheter 508 can be used, for example, to deliver, operate, position, and / or deploy the prosthetic spacer device 200 in an implantable arrangement, as further described below.
With reference to FIG. 15, the third catheter 508 can include an inner or actuating shaft 512, a coupler 514, an outer shaft 520, a handle 522 (shown in schematic), and a clasp control member 524. .. The proximal end portion 520a of the outer shaft 520 may be coupled to the handle 522 and extend distally from the handle 522, and the distal end portion 520b of the outer shaft 520 may be coupled to the coupler 514. The proximal end portion 512a of the actuating shaft 512 may be coupled to the actuating knob 526. The actuating shaft 512 may extend distally from the knob 526 (scheduled) through the handle 522, the outer shaft 520, and the coupler 514. The actuating shaft 512 may be movable with respect to the outer shaft 520 and the handle 522 (eg, axially and / or rotatably). The clasp control member 524 may extend through the handle 522 and the outer shaft 520 and be axially movable with respect to the handle 522 and the outer shaft 520. The clasp control member 524 may also be axially movable with respect to the actuating shaft 512.
In some embodiments, the outer shaft 520 of the third catheter 508 can be configured to be maneuverable. For example, although not shown, the third catheter 508 can include a pullwire and a flexible, axially incompressible pullwire sleeve (eg, a spiral coil).
As best shown in FIGS. 12-13, the actuating shaft 512 of the third catheter 508 may be releasably coupled to the distal collar 208 of the prosthetic spacer device 200. For example, in some embodiments, the distal end portion 512b of the actuating shaft 512 may include a male thread that is configured to releasably engage the female thread of the bore 226 of the prosthetic spacer device 200. .. As such, the actuating shaft 512 is releasably secured to the distal collar 208 by rotating the actuating shaft 512 in the first direction (eg, clockwise) with respect to the distal collar 208 of the prosthetic spacer device 200. To do. Rotating the actuating shaft 512 in a second direction (eg, counterclockwise) with respect to the distal collar 208 of the prosthetic spacer device 200 releases the actuating shaft 512 from the distal collar 208.
Then, referring to FIGS. 12-14, the coupler 514 of the third catheter 508 may be releasably coupled to the proximal collar 210 of the prosthetic spacer device 200. For example, in some embodiments, the coupler 514 may include a plurality of flexible arms 528 and a plurality of stabilizer members 530. The flexible arm 528 can include an opening 532, a port 533 (FIG. 13), and a small hole 534 (FIG. 14).
The flexible arm 528 may be configured to pivot between a first or open configuration (FIG. 13) and a second or coupled configuration (FIGS. 12 and 14). In the first configuration, the flexible arm 528 extends radially outward with respect to the stabilizer member 530. In the second configuration, the flexible arm 528 extends axially parallel to the stabilizer member 530 and the small holes 534 overlap radially, as best shown in FIG. The flexible arm 528 can be configured (eg, shape-fixed) to be urged to the first configuration.
The prosthetic spacer device 200 may be releasably coupled to the coupler 514 by inserting the stabilizer member 530 of the coupler 514 into the guide opening 232 of the prosthetic spacer device 200. The flexible arm 528 of the coupler 514 may be radially inwardly pivoted from the first configuration to the second configuration, whereby the protrusion 230 of the prosthetic spacer device 200 is the flexible arm 528. Extends radially within the opening 532 of. The flexible arm 528 may be held in a second configuration by inserting and threading the distal end portion 512b of the actuating shaft 512 into the opening 536 of the small hole 534, which is the flexible arm 528. Prevents radial outward pivotal movement from the second configuration to the first configuration, thereby releasably coupling the prosthetic spacer device 200 to the coupler 514.
The prosthetic spacer device 200 may be released from the coupler 514 by retracting the actuating shaft 512 proximally with respect to the coupler 514 such that the distal end portion 512b of the actuating shaft 512 exits the opening 536 of the small hole 534. This allows the flexible arm 528 to pivot radially outward from the second configuration to the first configuration, thereby causing the protrusion 230 of the prosthetic spacer device 200 to be pivoted to the flexible arm 528. Pull out from opening 532. The stabilizer member 530 can remain inserted into the guide opening 232 of the prosthetic spacer device 200 during and after the flexible arm 528 is released. This can prevent, for example, the prosthetic spacer device 200 from moving (eg, shifting and / or swinging) while the flexible arm 528 is released. The stabilizer member 530 is then pulled out of the guide opening 232 of the prosthetic spacer device 200 by retracting the coupler 514 proximally with respect to the prosthetic spacer device 200, thereby releasing the prosthetic spacer device 200 from the coupler 514. Can be done.
Referring to FIG. 15, the outer shaft 520 of the third catheter 508 is axially coupled between the proximal end portion 520a, which is coupled to the handle 522, and the distal end portion 520b, which is coupled to the coupler 514. It may be an extending extension shaft. The outer shaft 520 may also include an intermediate portion 520c disposed between the proximal end portion 520a and the distal end portion 520b.
Referring to FIG. 16, the outer shaft 520 includes a plurality of axially extending lumens, including a working shaft lumen 538, and a plurality of control member lumens 540 (eg, four in the illustrated embodiment). Can be equipped with. In some embodiments, the outer shaft 520 may comprise more than four (eg, six) or less (eg, two) control member lumens 540.
The actuating shaft lumen 538 may be configured to receive the actuating shaft 512, and the control member lumen 540 may be configured to receive one or more clasp control members 524. The lumens 538, 540 may also be configured such that the actuating shaft 512 and clasp control member 524 may be movable (eg, axially and / or rotatable) with respect to the respective lumens 538, 540. Good. In certain embodiments, lumens 538, 540 may comprise a liner or coating that is configured to reduce friction within lumens 538, 540. For example, lumens 538, 540 can include a liner containing PTFE.
Still referring to FIGS. 15-16, the outer shaft 520 can be made of a variety of materials, including metals and polymers. For example, in one particular embodiment, the proximal end portion 520a may comprise stainless steel and the distal end portion 520b and intermediate portion 520c may comprise PEBA (eg, PEBAX®). The outer shaft 520 can also include an outer coating or coating, such as a polymer refluxing onto portions 520a, 520b, and 520c.
The outer shaft 520 may include one or more coil portions 542 that are arranged radially outward from lumens 538, 540. For example, in one particular embodiment, the outer shaft 520 may include a first coil 542a, a second coil 542b, and a third coil 542c. The first coil 542a may be the outermost coil in the radial direction, the third coil 542c may be the innermost coil in the radial direction, and the second coil 542b may be the first coil 542a and the third coil. It may be arranged in the radial direction between the coil 542c and the coil 542c.
The coil portion 542 may comprise a variety of materials and / or configurations. For example, coil portion 542 can be made of stainless steel. In one particular embodiment, the first coil 542a and the third coil 542c include a stainless steel coil wound in a left-handed configuration and the second coil 542b comprises a stainless steel coil wound in a right-handed configuration.
The coil portion 542 may also have various pitches. The pitch of one or more coil portions of coil portion 542 may be the same as or different from the pitch of one or more other coil portions 542. In one particular embodiment, the first coil 542a and the second coil 542b can have a first pitch (eg 0.74 inch) and the third coil has a second pitch (eg 0.14). Can be equipped with inches).
The outer shaft 520 may also include a coupling layer 544 that is arranged radially inward from the third coil 542c. Bonding layer 544 can be formed from a variety of materials, including polymers, such as PEBA (eg, PEBAX®).
As shown in FIGS. 17-19, the handle 522 of the third catheter 508 can include a housing 546, an actuating locking mechanism 548, a clasp control mechanism 550, and a flushing mechanism 552. With reference to FIG. 17, the distal end portion of the housing 546 may be coupled to the proximal end portion 520a of the outer shaft 520. The actuating locking mechanism 548, clasp control mechanism 550, and flushing mechanism 552 may be coupled to the proximal end of housing 546. The actuating locking mechanism 548 may be configured to selectively lock the position of the actuating shaft 512 with respect to the housing 546 and the outer shaft 520. The clasp control mechanism 550 may also be coupled to the proximal end portion of the clasp control member 524, fixing the clasp control member 524 with respect to the handle 522 and moving the clasp control member 524 with respect to the outer shaft 520 and the actuating shaft 512. Can be configured as The flushing mechanism 552 may be configured to flush the outer shaft 520 (eg, with saline) before inserting the outer shaft 520 into the patient's vascular system.
As best shown in FIGS. 18-19, the housing 546 of the handle 522 can include a body portion 554 and a nose portion 556 that is coupled to a distal end portion of the body portion 554. The body part 554 and the nose part 556 come together in a variety of ways, including fasteners 558 and / or pins 560 (eg, as shown in the illustrated embodiments), adhesives, and / or other binding means. Can be combined with. Housing 546 can be formed from a variety of materials, including polymers (eg, polycarbonate).
The body portion 554 of the housing 546 includes a plurality of working shaft lumens 562, a control member lumen 564 (FIG. 19), and a flushing lumen 566 fluidly connected to the working shaft lumen 562 (FIG. 18). Can have a lumen. As best shown in FIG. 19, the body portion 554 includes a plurality of control member tubes 570, each of which is at least partially disposed within the actuating tube 568 and the actuating shaft lumen 562 and the control member lumen 564. A tube (eg, a hypotube) may also be provided. The tubes 568 and 570 may be axially movable (eg, slidable) with respect to lumens 562 and 564, respectively.
The proximal end of the actuating tube 568 extends proximally from the body 554 and may be coupled to the knob 526 and the proximal end portion 512a of the actuating shaft 512. The proximal end of the control member tube 570 extends proximally from the body portion 554 and may be coupled to the clasp control mechanism 550 and the clasp control member 524.
The distal end of the tubes 568, 570 can be provided with flanges 572, 574 configured to engage a stopper to limit the axial movement of the tubes 568, 570 with respect to the housing 546. For example, the flanges 572 and 574 come into contact with the respective surfaces of the body 554 (eg, the lip) to prevent the tubes 568 and 570 from coming off completely from the proximal ends of lumens 562 and 564, respectively. Can be configured as
The actuating tube 568 may be configured to receive a proximal end portion of the actuating shaft 512 and be coupled to the proximal end portion thereof. The control member tube 570 may be configured to receive a portion of the clasp control mechanism 550, as further described below. Tubes 568, 570 can be formed from a variety of materials, including polymers and metals (eg, stainless steel).
In some embodiments, the body 554 is a plurality of sealing members 576 (eg, O-rings) configured to prevent or reduce blood leakage through the lumen and around the shaft and / or tube. Can be equipped with a ring). The sealing member may be secured with respect to the body 554, for example, by a fastener 578 (eg, a hollow locking or socket jam set screw).
As best shown in FIG. 19, the nose portion 556 of the housing 546 can comprise a plurality of lumens, including an actuating shaft lumen 580 and a control member lumen 582. The actuating shaft lumen 580 of the nose portion 556 may extend coaxially with the actuating shaft lumen 562 of the body portion 554. The proximal end of the control member lumen 582 of the nose portion 556 may be aligned with the control member lumen 564 of the body portion 554 at the proximal end of the nose portion 556 (ie, the lumens 582, 564 are in the same plane. is there). The control member lumen 582 may extend from the proximal end toward each other at an angle (ie, with respect to the control member lumen 564 of the body portion 554), and the distal end of the control member lumen 582 may be: An arrangement near the distal end of the nose portion 556 can intersect the working shaft lumen 580 of the nose portion 556. In other words, the proximal end of lumen 582 is in a first plane parallel to the longitudinal axis of the catheter (ie, the plane of control member lumen 564 of body 554) and the distal end of lumen 582. Is in a second plane parallel to the longitudinal axis of the catheter (ie, the plane of the working shaft lumen 562 of the body 554).
As best shown in FIG. 18, the working shaft lumen 580 of the nose portion 556 may be configured to receive the proximal end portion of the outer shaft 520. The proximal end portion of the outer shaft 520 can be attached to the nose portion 556 in a variety of ways, including adhesives, fasteners, friction fits, and / or other binding means.
Still referring to FIG. 18, the actuating locking mechanism 548 of the handle 522 may be coupled to the proximal end portion of the body portion 554 of the housing 546 to the actuating tube 568. The actuating locking mechanism 548 may be configured to selectively control the relative movement between the actuating tube 568 and the housing 546. This, in turn, selectively controls the relative movement between the actuating shaft 512 (which is coupled to the actuating tube 568) and the outer shaft 520 (which is coupled to the nose portion 556 of the housing 546).
In some embodiments, the actuating locking mechanism 548 comprises a locking configuration, which prevents relative movement between the actuating tube 568 and the housing 546, with the actuating tube 568 and the housing 546. It can be equipped with an open configuration that allows relative movement between. In some embodiments, the actuating locking mechanism 548 has one or more intermediate configurations (ie, in addition to the locking and unlocking configurations) that allow relative movement between the actuating tube 568 and the housing 546. However, the force required to cause relative movement is greater than when the actuating locking mechanism is in the open configuration.
As shown in FIG. 18 of an exemplary embodiment, the actuating locking mechanism 548 can include a lock (eg, a Tuohy-Borst adapter) 584 and a coupler (eg, a mess luer coupler) 586. The coupler 586 can be attached to the distal end of the lock 584 and coupled to the proximal end of the body 554 of the housing 546. The actuating tube 568 may extend coaxially through the lock 584 and the coupler 586. As such, rotating the knob 588 of the lock 584 in the first direction (eg, clockwise) increases the frictional engagement of the lock 584 on the actuating tube 568, thereby increasing the actuating tube 568 and the housing. Relative movement to and from the 546 can be made more difficult or completely prevented. Rotating the lock 584 knob 588 in a second direction (eg, counterclockwise) reduces the frictional engagement of the lock 584 on the actuating tube 568, thereby between the actuating tube 568 and the housing 546. It is possible to facilitate the relative movement of.
In other embodiments, the actuating locking mechanism 548 may include other configurations configured to prevent relative movement between the actuating tube 568 and the housing 546. For example, the actuating locking mechanism 548 may include a lock having a configuration similar to a stopcock valve in which the plunger portion of the valve selectively engages the actuating tube 568.
In some embodiments, the actuating locking mechanism 548 may include a release member (eg, set screw or pin). The release member can extend within the housing 546 and can selectively engage the actuating tube 568. When the release member is engaged with the actuating tube 568 (eg, by inserting the release member into the housing 546 and in contact with the actuating tube 568), the release member is, for example, the actuating tube 568, and therefore ( It is possible to prevent the actuating shaft 512 from completely exiting the respective lumens 568 and 580 (for example, when the anchor 204 is actuated). When the release member is released from the actuating tube 568 (eg, by pulling it out of the housing 546 and / or removing it from contact with the actuating tube 546), the actuating tube 568, and therefore the actuating shaft 512, is within each. It can be completely withdrawn from lumens 568, 580 (eg, when the prosthetic spacer device 200 is released from delivery device 502).
The clasp control mechanism 550 can include an actuator member 590 and one or more locking members 592 (eg, two in the illustrated embodiment). The distal end portion of the actuator member 590 may be coupled to the control member tube 570, which extends from the proximal end of the body portion 554 of the housing 546, as best shown in FIG. The locking member 592 may be coupled to the proximal end portion of the actuator member 590.
As shown in the illustrated embodiment, the actuator member 590 is optionally coupled to a first side portion 594 and a second side portion that is selectively coupled to the first side portion 594 by a connecting pin 598. Can be equipped with 596. The actuator member 590 is configured such that the first side portion 594 and the second side portion 596 move together when the connecting pin 598 is inserted through the first side portion 594 and the second side portion 596. Can be done. When the connecting pin 598 is pulled out, the first side 594 and the second side 596 can be moved with respect to each other. This may allow the clasp control member 524, which is releasably coupled to the first side 594 and the second side 596 by the locking member 592, to be actuated individually.
The connection between the first side 594 and the second side 596 allows the first side 594 and the second side 596 to move axially (ie, proximal and distal). However, when the connecting pin 598 is pulled out, it is configured so that it cannot move rotatably with respect to each other. It is configured, for example, to have a first side 594 with a key slot or groove and a second side 596 with a key protrusion or tongue corresponding to the key slot or groove of the first side 594. It can be achieved by configuring it to include. This can prevent, for example, the clasp control member 524 from twisting with respect to the outer shaft 520, or reduce its likelihood.
The first side portion 594 and the second side portion 596 can include an axially extending lumen 501. The distal end of lumen 501 may be configured to receive a proximal end portion of control member tube 570. The proximal end of lumen 501 may be configured to receive a portion of locking member 592. As mentioned above, the proximal end portion of the clasp control member 524 extends through each locking member 592.
The locking member 592 may be configured to selectively control the relative movement of the clasp control member 524 and the actuator member 590 between the first side portion 594 or the second side portion 596, respectively. The locking member 592 has a locking configuration that prevents relative movement between the clasp control member 524 and its respective first side 594 or second side 596, and the clasp control member 524 and its respective first. It can be provided with an open configuration that allows relative movement between the side 594 or the second side 596. In some embodiments, the locking member 592 also allows one or more relative movements between the clasp control member 524 and the respective first side 594 or second side 596, respectively. Although it may have an intermediate configuration (ie, in addition to the locking and unlocking configurations), the force required to cause relative movement is greater than when the locking member 592 is in the unlocking configuration.
As shown in the illustrated embodiment, the locking member 592 can have a configuration similar to that of a stopcock valve. Therefore, rotating the knob 503 in the first direction (eg, clockwise) increases the frictional engagement between the locking members 592 on the clasp control member 524 and the clasp control member 524 and each first. Relative movement between the side 594 or the second side 596 can be made more difficult or completely prevented. Rotating the knob 503 in a second direction (eg, clockwise) reduces the frictional engagement between the locking members 592 on the clasp control member 524, reducing the frictional engagement between the clasp control member 524 and its respective first side. Relative movement between the part 594 or the second side part 596 can be facilitated. In other embodiments, the locking member 592 can include other configurations that are configured to prevent relative movement between the locking members 592 on the clasp control member 524.
The flushing mechanism 552 can include a flushing tube 505 and a valve 507 (eg, a stopcock valve). The distal end of the flushing tube 505 is coupled to the flushing lumen 566 and can fluidly communicate and thus fluidly communicate with the working shaft lumen 562 of the body 554. The proximal end of the flushing tube 505 can be coupled to the valve 507. In this way, the flushing mechanism 552 can be configured to flush the outer shaft 520 (eg, with saline) before inserting the outer shaft 520 into the patient's vascular system.
The clasp control member 524 may be configured to manipulate the configuration of the clasp 206, as further described below. As best shown in FIG. 15, each of the clasp control members 524 can be configured as a suture (eg, wire or thread) loop. The proximal end portion of the clasp control member 524 may extend proximally from the proximal end portion of the clasp control mechanism 550 and may be releasably coupled to the locking member 592 of the clasp control mechanism 550. ..
From the locking member 592, the clasp control member 524 passes through the lumen 501 of the clasp control mechanism 550, the control member tube 570, the control member lumens 564 and 582 of the handle 522, and the control member lumen of the outer shaft 520. A loop extending distally through the 540 can be formed. The clasp control member 524 may extend radially outward from lumen 540, for example, through port 533 of coupler 514 (FIG. 13). The clasp control member 524 can then extend through the opening 234 of the clasp 206 (eg, similar to the opening 142 of the prosthetic spacer device 100). The clasp control member 524 then returns proximally to the coupler 514, radially inward through port 533 of the coupler 514, and then proximally through the outer shaft 520 and handle 522, engaging the clasp control mechanism 550. It can extend to the stop member 592.
In FIG. 15, the clasp control member 524 is shown to be loose, and the clasp 206 is partially open to illustrate the clasp control member 524 extending through the opening 234 of the clasp 206. However, the clasp 206 is in a closed configuration, usually when the clasp control member 524 is loose.
As shown in the illustrated embodiment, each of the clasp control members 524 may extend through a plurality of control member lumens 540 of the outer shaft 520. For example, each of the clasp control members 524 may loop through two of the lumen 540. In other embodiments, each of the clasp control members 524 may be disposed within a single control member lumen 540. In yet another embodiment, a plurality of clasp control members 524 may be disposed within a single control member lumen 540.
With the clasp control member 524 coupled to the clasp 206, the clasp control mechanism 550 can be used to operate the clasp 206 between the open and closed configurations. The clasp 206 can be opened by moving the actuator member 590 proximally with respect to the knob 526 and housing 546. This increases the tensile force of the clasp control member 524 and moves the clasp 206 from the closed configuration to the open configuration. The clasp 206 can be closed by moving the actuator member 590 distally with respect to the knob 526 and housing 546. This reduces the tensile force on the clasp control member 524 and allows the clasp 206 to move from the open configuration to the closed configuration. The clasp 206 can be actuated individually by removing the connecting pin 598 and moving the first side 594 or the second side 596 to each other, to the knob 526, and with respect to the housing 546.
When the handle 522 is assembled as best shown in FIGS. 17-18, the actuating shaft 512 passes distal to the knob 526 through the actuating tube 568 and through the working lumens 562, 580 of the housing 546. , Can extend distally through the working shaft lumen 538 of the outer shaft 520 and through the coupler 514.
20-27 show that the delivery assembly 500 is used, for example, to implant the prosthetic spacer device 200 into the natural mitral valve 600 of the heart 602 using a transseptal delivery approach. Although not shown, a guide wire can be inserted into the patient's vasculature (eg, femoral vein) through the introducer sheath. The guide wire is advanced through the femoral vein, through the inferior vena cava, into the right atrium, through the atrial septum 604 (eg, via the foramen ovale), and into the left atrium 606. obtain. The first sheath 516 of the first catheter 504 may be advanced on a guide wire so that the distal end portion of the first sheath 516 is located within the left atrium 606, which is shown in FIG. Most often shown in.
If the prosthetic spacer device 200 is coupled to a third catheter 508 (eg, as shown in FIG. 12), is radially compressed, and is configured in a delivery configuration, the prosthetic spacer device 200 is a second catheter. Loaded into the second sheath 518 of the 506, the prosthetic spacer device 200 can be held in the delivery configuration. In this way, the distal end portion of the second sheath 518 serves as a delivery capsule for the prosthetic implant 200. In some embodiments, the radialally compressed delivery configuration may be an axially extending configuration (eg, similar to the configuration shown in FIG. 20). In other embodiments, the radialally compressed delivery configuration may be an axially shortened configuration (eg, similar to the configuration shown in FIG. 22). The second catheter 506, along with the prosthetic spacer device 200 and the third catheter 508, then has the distal end portion of the second sheath 518, as shown in FIG. 20, the distal end portion of the first sheath 516. It may extend outwardly from and be advanced together and passed through the first catheter 504 until it is disposed within the left atrium 606.
As shown in FIG. 20, the prosthetic spacer device 200 advances the outer shaft 520 and actuating shaft 512 of the third catheter 508 distally with respect to the second sheath 518 and / or the outer shaft 520 and actuating shaft 512. With respect to, the second sheath 518 may be retracted to advance from the second sheath 518, whereby the anchor 204 can be forced forward from the second sheath 518. After being exposed from the second sheath 518, the anchor 204 retracts the working shaft 512 of the third catheter 508 with respect to the outer shaft 520 of the third catheter 508 and / or advances the outer shaft 520 with respect to the working shaft 512. The anchor 204 can be folded by bending it from the configuration shown in FIG. 20 to the partially folded configuration shown in FIG. 21 and then to the fully folded configuration shown in FIG. This is achieved, for example, by disengaging the actuating locking mechanism 548 (eg, by rotating the knob 588 counterclockwise with respect to the handle 522) and then moving the knob 526 proximally with respect to the housing 546. obtain. At any point in the procedure, the physician can lock the relative positions of the actuating shaft 512 and the outer shaft 520, and thus the position of the anchor 204, by activating the actuating locking mechanism 548.
The prosthetic spacer device 200 is then coaxial with respect to the natural mitral valve 600 by manipulating (eg, maneuvering and / or bending) the second sheath 518 of the second catheter 506, as shown in FIG. Can be positioned to. The curvature of the second sheath 518 can be adjusted so that the distal maneuverable section 518a extends at an angle of approximately 90 degrees with respect to the section 518b extending proximally from the maneuverable section 518a (eg,). By maneuvering mechanism). Conveniently, this positions the maneuverable distal section 518a and the prosthetic spacer device 200 along an axis that is substantially perpendicular to the plane defined by the natural mitral valve. In other words, the axis extending through the maneuverable distal section 518a and the prosthetic spacer device 200 is coaxial or substantially parallel to the flow path of the natural mitral valve. is there.
With respect to the first sheath 516 of the first catheter 504 and the left atrium 606, the outer shaft 520 of the second sheath 518 of the second catheter 506 and the third catheter 508 is retracted (eg, in the direction indicated by arrow 521). Or, when advanced, the lateral shaft 520 and prosthesis spacer device 200 of the third catheter 508 move medially and laterally (eg, in the direction indicated by arrow 523 in FIG. 28) with respect to the spontaneous valve apex 608. A prosthetic spacer device for a natural mitral valve in the upward / downward direction (eg, up / down in the orientation shown in FIG. 22) when the second sheath 518 and outer shaft 520 are advanced and / or retracted. The positioning of the 200 remains at least substantially constant, and / or the second sheath 518 does not "whist" due to the configuration of the maneuvering mechanism of the second catheter 506, which is explained above. Rotate (torque"" the second sheath 518 of the second catheter 506 (eg, in the direction indicated by arrow 525 in FIG. 22) with respect to the first sheath 516 of the first catheter 504 and the left atrium 606. The outer shaft 520 and prosthesis spacer device 200 of the third catheter 508 are pivoted anteriorly / posteriorly (eg, in the direction indicated by arrow 527 in FIG. 28). The prosthetic spacer device 200 can also be rotated with respect to the natural mitral valve 600 (eg, by rotating the housing 546) to align the anchor 204 with the natural valve apex 608 of the natural mitral valve 600. Positioning of the prosthetic spacer device 200 with respect to the natural mitral valve in the superior / inferior direction (eg, up / down in the orientation shown in FIG. 22) is the positioning of the third catheter 508 with respect to the second sheath of the second catheter 506. It can be adjusted by retracting / advancing the outer shaft 520 of the. Therefore, one advantage of the disclosed delivery device is that the prosthetic spacer device is positioned in three directions. That is, it can be adjusted independently (inside / outside, front / rear, and top / bottom). For example, activating the delivery device to move the prosthetic spacer device inward / outward does not affect the positioning of the prosthetic spacer device in the anterior / posterior or superior / downward direction. Therefore, the three-way and / or independent maneuverability of the delivery device 502 allows the physician to place the prosthetic spacer device 200 at the desired implantation position with respect to the natural valve leaflet in a relatively fast and / or easy manner (eg, of the natural valve leaflet). Allows accurate and / or precise positioning (at A2 / P2 positions near the center of junction line 612 (Figure 28)).
The anchor 204 of the prosthetic spacer device 200 is then partially opened to the configuration shown in FIG. 23 by moving the knob 526 distally with respect to the housing 546 (ie, radial outward with respect to the spacer member 202). May be moved to). The prosthetic spacer device 200 is then advanced by advancing the handle 522 of the third catheter 508 with respect to the second catheter 506 and passed through the loop of the natural mitral valve 600, at least partially in the left ventricle 610. It may be sent to. The prosthetic spacer device 200 is then positioned such that the anchor 204 is positioned behind the ventricular portion of the spontaneous valve apex 608 (eg, A2 / P2 position) and the spacer member 202 is located on the atrial side of the spontaneous valve apex 608. , Partially retracted. Alternatively, the prosthetic spacer device 200 can be advanced in a fully folded configuration (as shown in FIG. 22) and passed through a natural valve, after which the anchor 204 can be opened.
In this configuration, the natural valve leaflet 608 can be secured with respect to the anchor 204 by capturing the natural valve leaflet with the clasp 206. The natural valve leaflets 608 can be captured simultaneously or separately by activating the actuator member 590. For example, FIG. 24 shows separate valve leaflet capture. This can be achieved by removing the connecting pin 598 from the actuator member 590 and moving the first side 594 or second side 596 to each other, to the knob 526, and with respect to the housing 546. Moving the first side 594 or second side 596 distally with respect to the knob 526 and housing 546 closes the clasp 206 on the spontaneous valve apex 608 (eg, left as illustrated in FIG. 24). As indicated by clasp 206). Moving the first side 594 or second side 596 proximally with respect to the knob 526 and housing 546 opens the clasp 206 (eg, as indicated by the right clasp 206 as illustrated in FIG. 24). To). After the clasp 206 is closed, the physician can reopen the clasp 206 and adjust the positioning of the clasp 206.
When the clasp 206 is reopened, the clasp 206 first moves inward radially inward towards the spacer member 202 until the clasp 206 first contacts the spacer member 202 (eg, as shown in FIG. 23). Move (as shown by the right clasp 206). In some cases, the barb 236 of the clasp 206 may hold the natural valve leaflet 608 when the clasp 206 is reopened and pull the natural valve leaflet 608 towards the spacer member 202. After the clasp 206 comes into contact with the spacer member 202, further pulling on the clasp control member 524 causes the clasp 206 to move slightly proximal to the spacer member 202 (and slightly widen the anchor 204). Proximal movement of the clasp 206 allows, for example, the barb 236 to be pulled out of the spontaneous valve apex 608, which facilitates repositioning and / or removal of the prosthetic spacer device 200.
If both natural valve leaflets 608 are secured within the clasp 206, the physician can move the knob 526 proximally with respect to the housing 546. This pulls the anchor 204, thus pulling the natural valve leaflet 608 radially inward with respect to the spacer member 202, as shown in FIG. The physician can then observe the positioning and / or reduction of reflux. If repositioning or removal is desired, the physician can reopen the anchor 204 and / or the clasp 206.
After the desired positioning and / or reduction of reflux is achieved, the physician can release the prosthetic spacer device 200 from the delivery device 502. The clasp 206 may be released from the delivery device 502 by releasing the clasp control member 524 from the locking member 592 and unscrewing the clasp control member 524 from the opening 234 of the clasp 206. The distal collar 208 of the prosthetic spacer device 200 can be released from the delivery device 502 by rotating the knob 526 in a second direction with respect to the housing 546 so that the actuating shaft 512 exits the bore 226. The actuating shaft 512 can then be retracted proximally through the prosthetic spacer device 200 by pulling the knob 526 proximally with respect to the housing 546. The proximal collar 210 of the prosthetic spacer device 200 may be released from the delivery device 502 by retracting the actuating shaft 512 proximally with respect to the coupler 514 such that the distal end portion of the actuating shaft 512 exits the pit 534 of the coupler 514. This allows the flexible arm 528 of the coupler 514 to move radially outward from the protrusion 230 of the proximal collar 210. The stabilizer member 530 of the coupler 514 is then pulled out of the guide opening 232 of the proximal collar 210 by pulling the housing 546 proximally, thereby delivering the prosthetic spacer device 200 as shown in FIG. It can be released from device 502.
The shafts 512, 520 of the third catheter 508 may then be proximally retracted into the second sheath 518 of the second catheter 506, and the second sheath 518 of the second catheter 506 is the second. It can be retracted proximally into the first sheath 516 of one catheter 504. Catheter 504, 506, 508 may be proximally retracted and removed from the patient's vascular system.
With the prosthetic spacer device 200 implanted in the A2 / P2 position, the natural mitral valve 600 may, in some embodiments, be provided with a double valve opening during ventricular diastole, as shown in FIG. it can. During ventricular systole, the spontaneous valve apex 608 can be joined together and / or affixed to the prosthetic spacer device 200, as shown in FIG. 28, to prevent or reduce mitral regurgitation.
In another embodiment, the anchor 204 moves radially outward with respect to the spacer member 202 during ventricular diastole so that the natural mitral valve 600 has a single valve opening, as shown in FIG. It may be an open configuration. Anchor 204 joins the spontaneous valve apex 608 together and / or abuts on the prosthetic spacer device 200, as shown in FIG. 28, during ventricular systole to prevent or reduce mitral regurgitation. The spacer member 202 may be moved inward in the radial direction to form a closed configuration. When the anchor 204 opens and closes in the natural cardiac cycle, the clasp 206 can hold the natural valve apex 608 against the anchor 204, as shown in FIGS. 28-29.
By configuring the prosthetic spacer device 200 in this way, the natural valve leaflet 608 can be allowed to move naturally after implantation. This can, for example, promote antegrade blood flow during ventricular diastole, while reducing or preventing retrograde blood flow during ventricular systole. This can also reduce or prevent natural tissue damage to the natural valve leaflets. Over time, endothelialization can form a tissue bridge between the anchor and the spacer member.
30-31 show another exemplary embodiment of the handle 700 relative to the delivery device 502, especially for use with the third catheter 508. Referring to FIG. 30, the handle 700 may include a housing 702, an operation control mechanism 704, a clasp control mechanism 550, and a flushing mechanism (not shown, but see, for example, the flushing mechanism 552 in FIG. 17). it can. The housing 702 can include a body portion 706 and a nose portion 556. The nose portion 556 of housing 702 may be coupled to the proximal end portion of the outer shaft 520. The motion control mechanism 704, clasp control mechanism 550, and flushing mechanism 552 may be coupled to the proximal end of the body 706 of the housing 702.
The handle 700 is similar to the handle 522 except that the handle 700 is configured such that the rotational movement of the first knob 718 of the actuation control mechanism 704 with respect to the housing 702 causes axial movement of the actuating tube 568 and actuating shaft 512. Although it can be configured, the handle 522 is configured such that the axial movement (eg, pushing and pulling) of the knob 526 with respect to the housing 546 causes the axial movement of the working tube 568 and the working shaft 512.
As mentioned above, the housing 702 can include a body portion 706 and a nose portion 556. Referring to FIG. 31, the main body 706 of the housing 702 may include an working lumen 708, a control member lumen 710, and a flange portion 712. Flange portion 712 may extend axially from the proximal end portion of body portion 706 and annularly around the working lumen 708.
The flange portion 712 of the body portion 706 may include one or more circumferential grooves 714, a bore (not shown), and a guide pin 716. Groove 714 may be configured to interact with motion control mechanism 704, as further described below. The bore may extend radially inward from the outer diameter to the inner diameter of the flange portion 712 and may be configured to receive the guide pin 716. The guide pin 716 may be partially disposed within the bore and may extend radially inward from the bore such that the guide pin 716 projects into the working lumen 708.
Still referring to FIG. 31, the motion control mechanism 704 can include a first knob 718, a mounting pin 720, a drive screw 722, a collet 724, and a second knob 726. The first knob 718 can have a distal end portion 728 and a proximal end portion 730. The first knob 718 may be configured such that the inner diameter of the distal end portion 728 is relatively larger than the inner diameter of the proximal end portion 730. The distal end portion 728 may include a side opening 732 that extends radially inward from the outer diameter to the inner diameter of the distal end portion 728.
With reference to FIG. 30 again, the inner diameter of the distal end portion 728 may be configured such that the distal end portion 728 of the first knob 718 extends over the flange portion 712 of the body portion 706. The opening 732 (FIG. 31) may be configured to axially align with the groove 714 when the first knob 718 is disposed over the flange portion 712. The mounting pin 720 may be configured to extend through the opening 732 of the first knob 718 and penetrate into the groove 714 of the flange portion 712. In this way, the mounting pin 720 allows relative rotational movement between the first knob 718 and the flange portion 712, hindering relative axial movement.
The inner diameter of the proximal end portion 730 of the first knob 718 can have a female screw (not shown) configured to engage the corresponding male screw 734 of the drive screw 722. As best shown in FIG. 31, the drive screw 722 can have a slot 736 that extends axially across the male screw 734. Slot 736 may be configured to receive guide pin 716 of flange portion 712. As such, when the handle 700 is assembled (Figure 30) and the first knob 718 is rotated with respect to the flange portion 712, the guide pin 716 has the drive screw 722 rotating with the first knob 718. Move the drive screw 722 axially with respect to the first knob 718 and the flange portion 712. In this way, rotating the first knob 718 in the first direction (eg clockwise) causes the drive screw to move distally with respect to the housing 702 and the first knob 718 in the second direction (eg clockwise). When rotated counterclockwise, the drive screw moves proximally with respect to the housing 702.
The drive screw 722 can also have a lumen 738, as shown in FIG. Lumen 738 may be configured to allow the actuating tube 568 to extend through the drive screw 722. The lumen 738 may be configured such that the distal end portion 740 of the collet 724 can also be inserted into the proximal end portion of the lumen 738.
The second knob 726 can include a first distal portion 742 and a second proximal portion 744. The distal portion 742 can include a female screw (not shown) corresponding to the male screw 734 of the drive screw 722. The proximal portion 744 can comprise a conical inner surface that is configured to engage the proximal end portion 746 of the collet 724.
When assembled (FIG. 30), the actuating tube 568 may extend through the lumen 738 of the drive screw 722, through the collet 724, and through the second knob 726. The second knob 726 may be disposed above the collet 724, and the female screw of the distal portion 742 of the second knob shall engage screwably with the male screw 734 of the drive screw 722. Can be done. Therefore, by rotating the second knob 726 in the first direction (eg, clockwise) with respect to the drive screw 722, the proximal portion 744 of the second knob 726 is directed towards the proximal end portion 746 of the collet 724. It is moved, thereby urging the collet 724 inward in the radial direction to hit the working tube 568. As a result, the actuating tube 568 and drive screw 722 move axially together as the first knob 718 rotates with respect to the housing 702. Rotating the second knob 726 in the second direction (eg, counterclockwise) with respect to the drive screw 722 keeps the distal portion 742 of the second knob 726 away from the proximal end portion 746 of the collet 724, which Allows the collet 724 to move radially outward with respect to the actuating tube 568. As a result, the actuating tube 568 and the drive screw 722 can move relative to each other.
In place of or in addition to the collet 724, the actuation control mechanism 704 of the handle 700 may include a release member (eg, set screw or pin). The release member may extend within the housing 702 (eg, near the proximal end of the housing 702) and selectively (eg, screwable) engage the drive screw 722 and actuation tube 568. Can be done. When the release member is engaged with the drive screw 722 and actuating tube 568 (eg, by inserting the release member into the housing 702 and bringing it into contact with the drive screw 722 and actuating tube 568), the release member is described, for example. The actuating tube 568 can be prevented from moving with respect to the drive screw 722, thus preventing the actuating shaft 512 from completely exiting the respective lumens 568, 580 (for example, when the anchor 204 is actuated). it can. When the release member is released from the drive screw 722 and actuating tube 568 (eg, by pulling it out of the housing 702 and / or removing it from contact with actuating tube 546), the actuating tube 568, and therefore the actuating shaft 512, It can be moved with respect to the drive screw 722 and thus can be completely pulled out of its respective lumens 568,580 (eg, when the prosthetic spacer device 200 is released from the delivery device 502).
When the prosthetic spacer device 200 is coupled to the actuating shaft 512 and the outer shaft 520 of the delivery device 502, the physician will use the actuation control mechanism 704 of the handle 700 to the prosthetic spacer device 200 with respect to the spacer member 202 of the prosthetic spacer device 200. The anchor 204 can be operated. The actuation control mechanism 704 is actuated by rotating the second knob 726 in the first direction with respect to the drive screw 722, allowing the actuating tube 568 and thus the actuating shaft 512 to be secured to the drive screw 722. The physician can then rotate the first knob 718 with respect to the housing 702, whereby the drive screw 722 and thus the actuating tube 568 and the actuating shaft 512 are axially moved with respect to the housing 702 and thus the outer shaft 520. It then moves the anchor 204 (which is coupled to the actuating shaft 512 via the distal collar 208) with respect to the spacer member 202 (which is coupled to the outer shaft 520 via the coupler 514 and the proximal collar 210).
The prosthetic spacer device 200 can be released from the delivery device 502 by rotating the second knob 726 in the second direction with respect to the drive screw 722. This allows the actuating tube 568 and thus the actuating shaft 512 to move with respect to the drive screw 722. The shafts 512, 520 of the delivery device 502 can then be removed from the collars 208, 210 of the prosthetic spacer device 200, respectively, as described above.
Configuring the delivery device to accompany the motion control mechanism 704 can provide several advantages. For example, the rotational force required to actuate the first knob 718 of the handle 700 may be less than the axial force required to actuate the knob 526 of the handle 700.
The actuation control mechanism 704 also compares the anchor 204 because the axial movement of the actuating shaft 512 rather than the axial movement of the knob 526 is controlled by the rotation of the first knob 718 and the thread pitch of the drive screw 722. It enables precise control. In other words, the actuation control mechanism 704 may be configured, for example, so that one rotation of the first knob 718 moves the actuation shaft 512 by a small axial distance (eg 1 mm), but the knob 526 and thus the actuation shaft 512 It can be relatively difficult to move axially in small increments (eg 1 mm).
In addition, the motion control mechanism 704 can prevent or reduce the shaft 512 from being inadvertently moved and released. For example, the actuation control mechanism 704 requires a rotational movement of the first knob 718 to move the actuation shaft 512, so this prevents the actuation shaft 512 from moving in the event of inadvertent contact with the knob 526. Or the possibility can be reduced. The physician also rotates the knob 526 to release the actuating shaft 512 from the distal collar 208 of the prosthetic spacer device 200 and the actuating tube 568 from the drive screw 722 before the actuating shaft 512 can be retracted proximally. The second knob 726 must be rotated to do so. This two-step release process can reduce the likelihood that the physician will inadvertently release the prosthetic spacer device 200 from the delivery device 502.
32 to 33 show exemplary embodiments of the coupler 800 and the proximal collar 802. Although not shown, the coupler 800 may be coupled to the distal end portion of the outer shaft 520 (FIG. 16) similar to the coupler 514. As shown, the proximal collar 802 can be coupled to the proximal end portion of the spacer member 202 in a manner similar to the proximal collar 210 (FIG. 13). As such, the coupler 800 and the proximal collar 802 allow the prosthetic spacer device 200 to be released to the outer shaft 520 (FIG. 16), respectively, instead of the coupler 514 and the proximal collar 210 of the delivery assembly 500, respectively. Can be used to combine.
With reference to FIG. 33, the coupler 800 may include an axially extending lumen 804 and a plurality of radially extending openings 806. Lumen 804 may be configured to receive an actuating shaft 512 (FIG. 32). The opening 806 may be configured to receive the proximal collar 802, as further described below.
The proximal collar 802 can include multiple proximal extension tabs or fingers 808. The free end portion 810 of the finger 808 may have a radial extension protrusion 812 formed on the free end portion 810. The finger 808 may be configured to pivot between a first or dormant state (FIG. 33) and a second or deflected state (FIG. 32). In the first state, the free end portions 810 of the finger 808 press against each other inward in the radial direction. In the second state, the free end portions 810 of the fingers 808 are radially spaced apart from each other.
With reference to FIG. 32, the coupler 800 and the proximal collar 802 can be releasably coupled together by positioning the finger 808 of the proximal collar 802 within the coupler 800. The actuating shaft 512 is then advanced through the lumen 804 of the coupler 800 and through the finger 808 of the proximal collar 802, thereby moving the free end portion 810 of the finger 808 from the first state to the second state. Can be pivoted outward in the radial direction. The protrusion 812 of the finger 808 and the opening 806 of the coupler 800 are rotatably aligned so that the protrusion 812 extends within the opening 806, thereby releasably coupling the coupler 800 to the proximal collar 802. Can be done. The coupler 800 may be released from the proximal collar 802 by retracting the actuating shaft 512 from the finger 808 of the proximal collar 802. This allows the free end portion 810 of the finger 808 to pivotally return from the second state to the first state, pulling the protrusion 812 of the finger 808 out of the opening 806 of the coupler 800, which Releases the coupler 800 from the proximal collar 802.
In some embodiments, the finger 808 of the proximal collar 802 can be configured to form a hemostatic seal when the finger 808 is in the first state. This can prevent or reduce blood from flowing through the proximal collar 802, for example, when the prosthetic spacer device 200 is implanted in the patient's body.
34-35 show exemplary embodiments of distal collar 900, actuating shaft 902, and open member (eg, wire) 904 that can be used, for example, with delivery assembly 500. Although not shown, the distal collar 900 can be attached to the distal end portion of the prosthetic spacer device 200. The proximal end portion of the actuating shaft 902 (not shown) may be coupled to the actuating tube 568 and knob 526. The actuating shaft 902 may extend distally from the proximal end portion through the handle 522 (FIG. 17), through the outer shaft 520 (FIG. 17), and into the prosthetic spacer device 200 (FIG. 12). The distal end portion of the actuating shaft 902 may be releasably coupled to the distal collar 900 of the prosthetic spacer device 200. As such, the distal collar 900 and actuation shaft 902 may be used, for example, in place of the actuating shaft 512 of the distal collar 208 and delivery assembly 500, respectively.
With reference to FIG. 35, the distal collar 900 can include a central bore 906 and a tab or tongue 908 formed (eg, laser cut) within the side 910 of the distal collar 900. The tongue 908 may have an opening 912 formed therein (eg, laser cut).
The central bore 906 may be configured to receive the distal end portion of the actuating shaft 902. The tongue 908 may be pivotable with respect to the lateral 910 of the distal collar 900 from the first or resting configuration (FIG. 35) to the second or deflecting configuration (FIG. 34). In the first configuration, the tongue 908 may be coplanar with the side surface 910. In the second configuration, the tongue 908 may extend radially inward with respect to the side surface 910 and project into the central bore 906. The tongue 908 can be urged towards the first configuration (eg, shape-fixed).
The tongue 908 can be used, for example, to releasably connect the distal collar 900 to the actuating shaft 902, as shown in FIG. For example, the actuating shaft 902 can be inserted into the central bore 906 of the distal collar 900. The tongue 908 is then assumed to be pressed radially inward from the first configuration to the second configuration so that the tongue 908 is pressed against the actuating shaft 902 and frictionally holds the actuating shaft 902 with respect to the collar 900. Good. The release member 904 can then be advanced distally such that the distal end portion 914 of the release member 904 extends through the opening 912 of the tongue 908. And Therefore, the release member 904, the tongue 908 of the second configuration and held held against the actuating shaft 902, thereby releasably coupling the distal collar 900 to the actuating shaft 902.
The distal collar 900 can be released from the actuating shaft 902 by retracting the release member 904 proximally so that the distal end portion 914 of the release member 904 exits the opening 912 of the tongue 908. This allows the tongue to return radially outward from the second state to the first state, thereby releasing the distal collar 900 from the actuating shaft 902.
This configuration can bring several advantages. For example, in some embodiments, the distal collar 900 and actuating shaft 902 can be formed without threads. Removing the threads makes it easier to manufacture the distal collar 900 and the actuating shaft 902, and / or lowers the manufacturing cost. Removing the threads from the working shaft 902 can also reduce the chance that the working shaft 902 will catch or catch another component of the delivery assembly 500.
36-37 show exemplary embodiments of coupler 1000, proximal collar 1002, distal collar 1004, and actuating shaft 1006 that can be used, for example, with delivery assembly 500. With reference to FIG. 36, the coupler 1000 may be coupled to the distal end portion of the outer shaft 520. The proximal collar 1002 may be coupled to the proximal end portion of the prosthesis spacer device 200 (scheduled in partial cross-section), and the distal collar 1004 may be coupled to the distal end portion of the prosthesis spacer device 200. Can be done. The proximal end portion of the actuating shaft 1006 (not shown) may be coupled to the actuating tube 568 and knob 526. The actuating shaft 1006 may extend distally from the proximal end portion through the handle 522 (FIG. 17), through the outer shaft 520 (FIG. 17), and into the prosthetic spacer device 200 (FIG. 12). The distal end portion of the actuating shaft 1006 may be releasably coupled to the distal collar 1004 of the prosthetic spacer device 200. As such, the coupler 1000, the proximal collar 1002, the distal collar 1004, and the actuating shaft 1006 are, for example, the coupler 514, the proximal collar 210, the distal collar 208, and the actuating shaft 512 of the delivery assembly 500, respectively. Can be used instead.
Referring to FIG. 37, the coupler 1000 includes a connecting portion 1008, a plurality of pins 1010 (eg, three in the illustrated embodiment), and one or more fixing members 1012 (eg, in the illustrated embodiment). 3) and can be provided. The pin 1010 and the fixing member may be coupled to the connecting portion 1008 and extend distally from the connecting portion 1008.
The connecting portion 1008 can have an axially extending lumen 1014 configured to slidably receive the actuating shaft 1006. In some embodiments, the connecting portion 1008 is also configured to be inserted into the distal end portion of the outer shaft 520, as shown in FIG. 36, a recessed outward surface 1015 (FIG. FIG. 37) can have.
As best shown in FIG. 37, the pins 1010 may be aligned with respect to each other and with respect to the fixing member 1012. The fixing members 1012 may be arranged so as to be spaced apart from each other on the circumference. In some embodiments, the pin 1010 and the fixing member 1012 may be arranged and configured in an alternating pattern (eg, pin-fixing member-pin) on the connecting portion 1008.
With reference to FIG. 36, the pin 1010 may be configured to extend within the opening 1016 of the proximal collar 1002. In some embodiments, the fixation member 1012 may be a suture loop. The fixing member 1012 may be configured to extend through the opening 1016 of the proximal collar 1002 and extend around the actuating shaft 1006. For clarity, FIG. 36 shows only one fixing member 1012 extending around the actuating shaft 1006.
Referring again to FIG. 37, in addition to the opening 1016, the proximal collar 1002 can include a central lumen 1018 that is arranged radially inward from the opening 1016. The central lumen 1018 may extend axially and may be configured to slidably receive the actuating shaft 1006, as shown in FIG.
The distal collar 1004 can be configured similar to a sleeve so that the actuating shaft 1006 can slidably extend through the distal collar 1004, as shown in FIG.
The actuating shaft 1006 may include a radially expandable portion 1020 located at or near the distal end portion 1022 of the actuating shaft 1006. The radial expandable portion 1020 may be configured to be selectively expandable from a compressed configuration to an expanded configuration. For example, the radial expandable portion 1020 may be an inflatable balloon or an expandable mesh (eg, braided) basket.
The radial expandable part 1020 has an outer diameter of the radial expandable part 1020 when the radial expandable part 1020 is in a compression configuration, the inner diameter of the distal collar 1004, the central lumen 1018 of the proximal collar 1002, and the coupler. It can be configured to be smaller than 1000 lumens 1014. When the radial expandable part 1020 is in the expansion configuration, the outer diameter of the radial expandable part 1020 is larger than the inner diameter of the distal collar 1004. Thus, in an extended configuration, the radial expandable portion 1020 can prevent the distal end portion 1022 from moving proximally with respect to the distal collar 1004.
As shown in FIG. 36, the prosthetic spacer device 200 may be releasably coupled to the outer shaft 520 and the actuating shaft 1006 by inserting the pin 1010 and the fixing member 1012 into the respective openings 1016 of the proximal collar 1002. .. When the radially expandable portion 1020 is in a compression configuration, the actuating shaft 1006 is advanced distally so that the radially expandable portion 1020 is disposed with respect to the distal collar 1004 and passes through the lumen of the coupler 1000. , May pass through the central lumen 1018 and fixation member 1012 of the proximal collar 1002 and through the distal collar 1004. The radial expandable portion 1020 of the working shaft 1006 may then be extended from a compression configuration to an expansion configuration, thereby allowing the prosthetic spacer device 200 to be releasably coupled to the outer shaft 520 and the working shaft 1006. it can.
The prosthesis spacer device 200 compresses the radially expandable portion 1020 of the actuating shaft 1006 and traverses the actuating shaft 1006 through the distal collar 1004 and through the central lumen 1018 of the fixation member 1012 and the proximal collar 1002. It can be released from the outer shaft 520 and the actuating shaft 1006 by retracting into. The outer shaft 520 is then retracted proximally with respect to the prosthetic spacer device 200 such that the pin 1010 and the fixing member 1012 are pulled out of the opening 1016 in the proximal collar 1002, thereby pulling the prosthetic spacer device 200 into the outer shaft 520. And can be released from the actuating shaft 1006.
38-39 show exemplary embodiments of clasp control member 1100 that can be used, for example, in place of clasp control member 524 in delivery assembly 500. Referring to FIG. 39, the clasp control member 1100 may include a sleeve 1102, a connecting member 1104, and a release member 1106. The connecting member 1104 and the releasing member 1106 may extend axially through the sleeve 1102 and may be movable with respect to the sleep 1102.
The proximal end portion of the sleep 1102 (not shown) may be coupled to the control member tube 570, and the distal end portion of the sleeve 1108 is a connecting member 1104 and a release member, as further described below. It can be releasably coupled to the clasp 206 of the prosthetic spacer device 200 by 1106.
The connecting member 1104 may be, for example, a suture loop extending distally from the clasp control mechanism 550 of the delivery device 502 through the control member tube 570, through the sleeve 1102, and through the opening 234 of the clasp 206. .. The connecting member 1104 may be releasably coupled to the clasp 206 of the prosthetic spacer device 200 by the release member 1106.
The release member 1106 may be, for example, a wire extending distally from the clasp control mechanism 550 of the delivery device 502 through the control member tube 570, through the sleeve 1102, and through the loop of the connecting member 1104. In this way, the release member 1106 releasably couples the connecting member 1104 and thus the sleeve 1102 to the clasp 206 by preventing the connecting member 1104 from exiting through the opening 234 of the clasp 206. The connecting member 1104 can be released from the clasp 206 by pulling the release member 1106 out of the loop of the connecting member 1104 and pulling the connecting member 1104 out of the opening 234 of the clasp 206.
When the sleeve 1102 is releasably coupled to the clasp 206 of the prosthetic spacer device 200 by the connecting member 1104 and the release member 1106, the clasp 206 moves the sleeve 1102 axially with respect to the outer shaft 520 and the actuating shaft 512 ( It can be operated either together or separately. This can be achieved, for example, by moving the actuator member 590, which is coupled to the sleeve 1102 via the control member tube 570, with respect to the housing 546 and the actuating tube 568. The clasp 206 can be opened by moving the actuator member 590 proximally with respect to the housing 546 and actuating tube 568, and the clasp 206 can be closed by moving the actuator member 590 distally with respect to the housing 546 and actuating tube 568. it can.
Since the sleeve 1102 is relatively rigid (for example, compared to the clasp control member 524), the sleeve 1102 can be used to push and close the clasp 206 (instead of urging the clasp 206 to the closed position). , Or in addition to that). Being able to push in this way can help ensure that the natural valve leaflets are trapped within the clasp 206 and thereby anchored to the anchor 204.
FIG. 40 shows an exemplary embodiment of the guide rail 1200. The guide rail 1200 may be coupled, for example, to the respective clasp 206 of the prosthetic spacer device 200. In some embodiments, the clasp control member 1100 may be releasably coupled to the guide rail 1200 in a snare fashion similar to that described above with respect to FIG. 39.
By connecting the clasp control member 1100 to the guide rail 1200 rather than directly to the clasp 206, the clasp control member 1100 is longitudinally along the guide rail 1200 as the clasp 206 moves between the open and closed configurations. Allows you to slide on. This may allow, for example, the clasp control member 1100 to maintain a relatively constant angle with respect to the anchor 204 when the clasp 206 is activated. For example, the clasp control member 1100 can slide outward toward the first side 1202 of the guide rail 1200 when the clasp 206 is pulled open, and the clasp control member 1100 has the clasp 206 When pushed and closed, it can slide inward towards the second side 1204 of the guide rail 1200. This can therefore reduce the force required to operate the clasp control member 1100.
FIG. 41 shows an exemplary embodiment of shaft 1300. The shaft 1300 can be used, for example, with the delivery device 502 instead of the outer shaft 520 of the third catheter 508. The shaft 1300 includes a plurality of axially extending lumens, including an actuating shaft lumen 1302, and a plurality of control member lumens 1304 (eg, exemplary) disposed radially outward from the actuating shaft lumen 1302. In the embodiment to be carried out, four, 1304a, 1304b, 1304c, 1304d-- (collectively referred to as "control member lumen 1304") may be provided. The control member lumens 1304 may be spaced apart from each other and may be evenly distributed over the circumference of the working shaft lumen 1302. For example, each of the control member lumens 1304 may be located approximately 90 degrees from an adjacent control member lumen 1304.
The actuating shaft lumen 1302 may be configured to receive the actuating shaft 512, and the control member lumen 1304 may be configured to receive the clasp control member 524. Lumens 1302, 1304 may also be configured such that the actuating shaft 512 and clasp control member 524 may be movable (eg, axially and / or rotatable) with respect to lumens 1302, 1304, respectively. .. In certain embodiments, lumens 1302, 1304 have a liner or coating (eg, PTFE) configured to reduce friction between lumens 1302, 1304 and the actuating shaft 512 and clasp control member 524, respectively. Can be prepared.
Each of the clasp control members 524 may extend through one or more of the control member lumens 1304 and extend around the clasp 206 of the prosthetic spacer device 200. For example, in some embodiments, each clasp control member 524 can extend through a pair of control member lumens 1304 that are offset by 90 degrees on the circumference. In one particular embodiment, the first clasp control member 524 may extend through lumens 1304a, 1304b and around the first clasp 206 of the prosthetic spacer device 200, second. The clasp control member 524 may extend through the lumens 1304c, 1304d and around the second clasp 206 of the prosthetic spacer device 200.
In such an embodiment, when the shaft 1300 is deflected in a direction oriented between the two lumens corresponding to one of the clasp control members 524 (eg, right as shown in FIG. 41). In addition, both lumens 1304a and 1304b are shortened because they are on the inner diameter of the curve, and both lumens 1304c and 1304d are extended because they are on the outer diameter of the curve. Since the clasp control member 524 is free to move axially within the lumen 1304, the tension of the first clasp control member 524 (located on the inner diameter of the curve) is reduced and therefore the first clasp 206. Can move slightly towards the closed configuration due to clasp urging, but the tension of the second clasp control member 524 (located on the outer diameter of the curve) increases and therefore the second clasp. The 206 can move slightly towards the open configuration. When the shaft 1300 is rotated 180 degrees, the lumens 1304a, 1304b and the first clasp control member 524 move from the inner diameter of the curve to the outer diameter of the curve, thereby increasing tension and raising the first clasp 206. Opening slightly, the lumens 1304c, 1304d and the second clasp control member 524 move from the outer diameter of the bend to the inner diameter of the bend, thereby reducing tension and closing the clasp 206 slightly.
In other embodiments, the first clasp control member 524 may extend through lumen 1304a, extend around first clasp 206, and extend through lumen 1304c. The second clasp control member 524 may extend through lumen 1304b, extend around the second clasp 206, and extend through lumen 1304d. Threading each clasp control member 524 through a pair of control member lumens 1304 offset by 180 degrees on the circumference can provide several advantages. For example, this configuration allows the clasp control member 524 to maintain uniform tension on the clasp 206 when the shaft 1300 is deflected and / or rotated (eg, when positioning the prosthetic spacer device 200). To. This is because the length of each lumen 1304 shortening / extending when the shaft 1300 is deflected and / or rotated is equal to, but opposite to, the length of each diagonally opposite lumen 1304 extending / shortening. This is because the clasp control member 524 can move with respect to the lumen 1304 and the clasp 206 when the lumen 1304 is shortened / extended by the length offset. Therefore, the clasp 206 of the prosthetic spacer device 200 maintains an open and / or closed configuration regardless of the deflection and / or rotation of the shaft 1300.
Shaft 1300 can be formed from a variety of materials, including metals and polymers. For example, in one particular embodiment, the shaft 1300 may include a first portion or layer 1306, a second portion or layer 1308, and a third portion or layer 1310. The first part 1306 may be the outermost part in the radial direction, the third part 1310 may be the innermost part in the radial direction, and the second part 1308 may be the first part 1306 and the third part. It may be arranged in the radial direction between the portion 1310 and the portion 1310. In some embodiments, the first portion 1306 and the third portion 1310 may be formed from a polymeric material (eg, PEBA with a Type D shore durometer value of 55D) and the second portion 1308 is a metal. It can be formed from a material (eg, braided stainless steel).
By configuring the shaft 1300 in this way, for example, control of the distal end portion of the shaft 1300 can be further improved. For example, this configuration has a "whipped" (eg, for example) at the distal end of the shaft 1300 when the shaft 1300 is rotated at the proximal end (for example, by rotating the housing 546 of the handle 522). , Sudden or sudden movement) can be prevented or reduced. As such, the physician will use the distal end of the shaft 1300 and thus the prosthetic spacer during implantation procedures, such as when the physician rotates the prosthetic spacer device to align the anchor of the prosthetic spacer device with the spontaneous valve leaflet. More precise control of the device (eg, prosthetic spacer device 200) can be performed.
Note that in some embodiments, the housing 546 of the handle 522 may comprise four control member lumens 564, 582 (ie, four each) coupled to the control member lumen 1304. As such, each longitudinal extension section of each clasp control member 524 may extend distally from the clasp control mechanism 550 of the handle 522 to the prosthetic spacer device 200 within a separate lumen.
42-45 show an exemplary delivery assembly 1400 with a prosthetic spacer device 1402 and a delivery device 1404. The prosthetic spacer device 1402 may be configured to reduce or prevent regurgitation through a natural heart valve (eg, a natural mitral valve). As shown in FIGS. 42-43 and 45, the prosthetic spacer device 1402 can be releasably coupled to the delivery device 1404, which can be used to implant the prosthetic spacer device.
With reference to FIG. 42, the prosthetic spacer device 1402 may include a spacer member 1406, a plurality of anchors 1408, and a plurality of clasps 1410. In some embodiments, the spacer member 1406, anchor 1408, and clasp 1410 may be configured similarly to the spacer member 202, anchor 204, and clasp 206 of the prosthetic spacer device 200, respectively.
The prosthetic spacer device 1400 can also include a proximal collar 1412, a sleeve or cylinder 1414, and a piston 1416. The proximal collar 1412 and cylinder 1414 may be coupled to the spacer member 1406 and the piston 1416 may be coupled to the anchor 1408.
The proximal collar 1412 is coupled to the proximal end portion of the spacer member 1406 (ie, the upper end portion as exemplified) and may extend annularly around the proximal end portion. Proximal collar 1412 can be used, for example, to couple the prosthetic spacer device 1400 to delivery device 1404, as further described below. In some embodiments, the proximal collar 1412 can have a connector member for receiving the tether 1432 of delivery device 1404. The connector member may include, for example, an opening, a small hole, and / or other suitable means for connecting the tether to the proximal collar 1412.
The cylinder 1414 is coupled to at least a portion of the spacer member 1406 and can extend coaxially through it. Cylinder 1414 can be attached to spacer member 1406 in a variety of ways, including fasteners, sutures, adhesives, welds, and / or other means for bonding. The cylinder 1414 can be sized and configured such that the piston 1416 can move axially through the cylinder 1414. As such, the cylinder 1414 is moved between various configurations, for example, the prosthetic spacer device 1400 is moved between shortened / functional configurations (eg, FIG. 42) and extension / delivery configurations (eg, FIG. 43). Sometimes it can be used as a guide for the piston 1416.
The distal end portion 1418 of piston 1416 may be coupled to the distal end portion 1420 of anchor 1408. This can be achieved in a variety of ways, including fasteners, sutures, adhesives, welds, and / or other means of binding. The proximal end portion 1422 of piston 1416 can be coupled to delivery device 1404. For example, in some embodiments, the proximal end portion 1422 of piston 1416 comprises a bore or opening 1424 with a female thread that is configured to receive the corresponding male thread of the actuating shaft 1428 of delivery device 1404. be able to. Piston 1416 (in combination with the delivery device) moves anchor 1408 between various configurations, for example, a folded / functional configuration (eg, FIG. 42) and a straight / delivery configuration (eg, FIG. 43). Can be used to
The delivery device 1400 comprises an implantable catheter (eg, similar to the third catheter 508 of the delivery device 502) having an outer shaft 1426, an actuating shaft 1428, a plurality of clasp control members 1430, and a plurality of tethers 1432. be able to. The outer shaft 1426 can be used, for example, to position the prosthetic spacer device 1402 during the implantation procedure of the prosthetic spacer device 1402. The actuating shaft 1428 can be used, for example, to move the prosthetic spacer device 1402 between a functional configuration (FIG. 42) and a delivery configuration (eg, FIG. 43). The clasp control member 1430 can be used, for example, to move the clasp 1410 between open and closed configurations. The tether 1432 can be used, for example, to connect the prosthetic spacer device 1402 to the outer shaft 1426.
With reference to FIG. 44, the outer shaft 1426 may include a plurality of lumens, including a working shaft lumen 1434, a plurality of control member lumens 1436, and a plurality of tether lumens 1438. The outer shaft 1426 may otherwise have a configuration similar to the outer shaft 520 and / or shaft 1300.
With reference to FIG. 42 again, the actuating shaft 1428 may have a configuration similar to the actuating shaft 512. In some embodiments, the distal end portion of the actuating shaft 1428 is configured to screwably fit the female thread of the opening 1424 in the proximal end portion 1422 of the piston 1416. Can be provided.
In other embodiments, the actuating shaft 1428 may be coupled to anchor 1408 of prosthetic spacer device 1402 in a variety of ways. Although not shown, the prosthetic spacer device 1402 may include, for example, a distal collar in place of or in addition to the piston 1416, which has a configuration similar to the distal collars 108, 208, 900, and / or 1004. The actuating shaft 1428 can have a configuration similar to the actuating shafts 512, 902, and / or 1006.
The clasp control member 1430 may have a configuration similar to the clasp control member 524 of the delivery device 502. The clasp control member 1430 may extend through the control member lumen 1436 of the outer shaft 1426 and extend around the clasp 1410 of the prosthetic spacer device 1402. The clasp control material 1430 can be taut to move the clasp 1410 to an open configuration. Loosening the clasp control member 1430 can allow the clasp 1410 to move into a closed configuration (by urging the clasp 1410 towards the closed configuration).
In some embodiments, each of the clasp control members 1430 may extend through two of the control member lumens 1436 of the outer shaft 1426. In some embodiments, each clasp control member 1430 extends through two control member lumens 1436, which are offset about 180 degrees from each other in a circumferential manner similar to that described above for shaft 1300. can do.
The tether 1432 may extend through the tether lumen 1438 of the outer shaft 1426 and extend around the proximal end of the prosthesis spacer device 1402 (eg, through the proximal collar 1412). The tether 1432 can be taut to pull the proximal end of the prosthetic spacer device 1402 towards the distal end of the outer shaft 1426 (eg, FIGS. 42-43). Loosening the tether 1432 can allow the proximal end portion of the prosthetic spacer device 1402 to separate from the distal end portion of the outer shaft 1426 (eg, FIG. 45).
In some embodiments, each of the tethers 1432 may extend through two of the tether lumens 1438 of the outer shaft 1426. In some embodiments, each tether 1432 can extend through two tether lumens 1438 that are offset about 180 degrees from each other.
If the prosthesis spacer device 1402 is coupled to the delivery device 1404 by the outer shaft 1426 (via the tether 1432), the actuating shaft 1428, and the clasp control member 1430, the delivery assembly 1400 is, for example, in the natural heart valve of the patient's heart. Can be used to implant the prosthesis spacer device 1402 in. This, for example, advances the prosthetic spacer device 1402 through the first and second catheters 506 of the delivery device 502 and delivers it into the patient's heart with the prosthetic spacer device 1402 of the delivery configuration (eg, FIG. 43). Can be achieved by The prosthetic spacer device 1402 can be advanced and ejected from the distal ends of the first catheter 504 and the second catheter 506. The prosthesis spacer device 1402 then moves the actuating shaft 1428 with respect to the outer shaft 1426 so that the piston 1416 moves through the cylinder 1414 and the proximal end portion 1422 of the piston 1416 is disposed adjacent to the proximal collar 1412. By moving proximally, it can be moved from a delivery configuration to a functional configuration (eg, Figure 42).
The actuating shaft 1428 and / or clasp control member 1430 of delivery device 1404 may be actuated to capture the spontaneous heart valve apex with the clasp 1410, which may be anchored to the spacer member 1406. This can be done in the same manner as that described above for delivery assembly 500 and shown in FIGS. 22-25.
The functionality and / or positioning of the prosthetic spacer device 1402 can be evaluated when the prosthetic spacer device 1402 is secured to the spontaneous valve leaflet. To evaluate, the physician, for example, releases the actuating shaft 1428 from the piston 1416 and proximalizes the actuating shaft so that the distal end portion of the actuating shaft is located within the central lumen 1434 of the outer shaft 1426. You can move. The clasp control member 1430 and tether 1432 are loosened so that the outer shaft 1426 is retracted away from the proximal end of the prosthesis spacer device 1402 and the distal end of the shaft 1426 can be spaced apart from the prosthesis spacer device 1402. obtain. In this way, the prosthetic spacer device 1402 is partially released from the delivery device 1400, while the clasp control member 1430 and the tether 1432 remain coupled to the prosthetic spacer device 1402. Since the clasp control member 1430 and tether 1432 are flexible and loose, the prosthetic spacer device 1402 can move and / or function as if it were completely freed from delivery device 1404. As a result, the partially released configuration prosthesis before the prosthetic spacer device 1402 is completely released, for example, than when a physician evaluates the prosthetic spacer device 1402 while connected to the outer shaft 1426 and / or the actuating shaft 1428. It may be possible to better evaluate the functionality and / or positioning of the spacer device 1402. This is because the outer shaft 1426 and / or the actuating shaft 1428 is relatively stiffer than the clasp control member 1430 and the tether 1432, and thus the prosthesis spacer device 1402 is partially or completely released from the delivery device 1404. This is because the position and / or hemodynamics of the spacer device 1402 can be altered.
If the physician wants to adjust the positioning of the prosthesis spacer device 1402, the tether 1432 is tightened and the distal end of the outer shaft 1426 is distal over the tether 1432 so that it abuts the proximal end of the prosthesis spacer device 1402. Can be moved forward. The actuating shaft 1428 can be advanced distally through the central lumen 1434 of the outer shaft 1426 and reconnected to the proximal end portion 1422 of piston 1416. The prosthetic spacer device 1402 can then be moved / repositioned with respect to the spontaneous valve apex by operating the actuating shaft 1428 and / or clasp control member 1430 to operate the anchors 1408 and / or clasp 1410, respectively. The physician can then reassess the positioning and / or functionality of the prosthetic spacer device 1402 and make additional adjustments if desired.
From the partially released configuration, the prosthetic spacer device 1402 is completely released from the delivery device 1404 by pulling the clasp control member 1430 from the clasp 1410 of the prosthetic spacer device 1402 and the tether 1432 from the proximal end of the prosthetic spacer device 1402. Can be done. The clasp control member 1430 and tether 1432 may then be retracted proximally into lumens 1436, 1438 of the outer shaft 1426, with the outer shaft along with the actuating shaft 1428 for the first catheter 504 and the second. It may be retracted proximally through catheter 506 and removed from the patient's body.
Tether 1432 allows the prosthetic implant to be implanted while still connected to the delivery device to evaluate the implant surgery, after which the implant is removed from the delivery device after the implant surgery has been confirmed by the doctor. It can be incorporated into any of the embodiments disclosed herein so as to be fully released.
46-54 show an exemplary embodiment of the handle 1500 and its components. Handle 1500 can be used, for example, with a third catheter 508 of delivery device 502 instead of handle 522. Referring to FIG. 46, the handle 1500 has five main components: a connecting member 1502, a flushing mechanism 1504, a housing 1506, an anchor actuating mechanism 1508, and a clasp actuating mechanism 1510.
The configuration of the handle 1500 is generally similar to the configuration of the handles 522, 700. The anchor actuating mechanism 1508 of the handle 1500 is described above by the user moving (eg, pushing / pulling) the actuating knob 1512 of the anchor actuating mechanism 1508 axially (eg, pushing / pulling), as further described below. Activating the anchor of the prosthesis spacer device (eg, anchor 204) by rotating the actuating knob 1512 (e.g., similar to the actuation of knob 718 described above). Is configured to enable. In this way, the anchor actuating mechanism 1508 provides both axial and rotational actuation of the anchor actuating mechanism 1508, which is also referred to herein as "hybrid actuation".
Still referring to FIG. 46, the connecting member 1502 may be coupled to the distal end portion of housing 1506 and the proximal end portion 520a of the outer shaft 520 (not shown). The connecting member 1502 may be configured to provide tension relief with respect to the outer shaft 520. By reducing the tension applied to the outer shaft, for example, kinking of the outer shaft 520 near housing 1506 can be reduced.
Next, referring to FIG. 47, the connecting member 1502 can have, for example, a substantially conical shape that tapers radially outward from the distal end portion 1514 to the proximal end portion 1516. The connecting member 1502 may also have one or more slits, or grooves 1518, which may facilitate bending. The slit 1518 may extend over the circumference of the connecting member 1502.
As shown in FIG. 46, the flushing mechanism 1504 of the handle 1500 is coupled to the housing 1506 and the outer shaft (not shown) and can communicate fluidly. In this way, the flushing mechanism 1504 can be used to flush the outer shaft (eg, with saline) before inserting the third catheter 508 into the patient's body.
As shown in FIG. 47, the housing 1506 of the handle 1500 can include a nose portion 1520 and a body portion 1522. The nose portion 1520 and the body portion 1522 can be joined together, for example, with fasteners (eg, bolts) 1524. The nose portion 1520 and the body portion 1522 may include a plurality of lumens, including an actuating shaft lumen 1526 and a control member lumen 1528. The actuating tube 1530 may be disposed within the actuating shaft lumen 1526 and may be axially movable with respect to the actuating shaft lumen 1526. The clasp control tube 1532 may be disposed within the control member lumen 1528 and may be axially movable with respect to the control member lumen 1528.
The body 1522 of housing 1506 can also include slots 1534 and bores 1536 that are configured to receive one or more components of the anchor actuating mechanism 1508, as further described below. Slot 1534 may extend radially and axially within the working shaft lumen 1526 of housing 1506. The bore 1536 may be located proximal to slot 1534 and may extend radially within the working shaft lumen 1526 of housing 1506.
In some embodiments, the housing 1506 can have a substantially triangular cross-sectional shape taken in a plane perpendicular to the longitudinal axis of the working lumen 1526. In other embodiments, the housing may have various other shapes such as rectangular, circular and the like.
The anchor actuating mechanism 1508 can be used to move the actuating shaft 512 axially with respect to the housing 1506 (and thus the outer shaft 520), and thus the anchor 204 of the prosthetic spacer device 200 (which can be coupled to the actuating shaft 512). The anchor actuating mechanism 1508 can also be used to release the actuating shaft from the prosthetic spacer device. Anchor actuation mechanism 1508 includes actuation tube 1530, drive screw 1538, actuation knob 1512, release knob 1540, release pin 1542, bushing 1544, mode selector button 1546, and urging element (eg, spring) 1548. And can be provided.
Referring to FIG. 48, the actuating tube 1530 has a flange 1550 disposed at the distal end portion of the actuating tube and a lumen 1552 extending from the distal end portion to the proximal end portion of the actuating tube. Can be done. Flange 1550 can be used, for example, to connect the actuating tube 1530 to release pins 1542 and bushing 1544. Lumen 1552 can receive, for example, an actuating shaft (eg, actuating shaft 512).
As shown in FIG. 48, the flange 1550 can have one or more recesses or "flats" 1554 (eg, two diagonally opposite sides of the flange 1550). In this way, the flange 1550 of the actuating tube 1530 may be inserted into the first opening 1556 (FIG. 49) of the bushing 1544, and the release pin 1542 is the actuating tube as shown in FIG. It may be inserted into the second opening 1558 (FIG. 49) of the bushing 1544 to join the 1530 and bushing 1544 together. With reference to FIG. 50, the release pin 1542 can have one or more tabs 1560 (eg, two in the illustrated embodiment) that are spaced apart by a groove 1562. Referring again to FIG. 51, the release pin 1542 tab 1560 and groove 1562 and / or the working tube 1530 flange 1550 are engaged with the release pin 1542 tab 1560 extending along the flat portion 1554 of the working tube 1530. Can have such sizes and configurations. In an engaging configuration (eg, FIG. 51), the release pin 1542 limits relative movement (eg, rotational and axial) between the actuating tube 1530 and the bushing 1544.
In some embodiments, the release pin 1542 and bushing 1544 can have locking elements 1564, 1566, respectively. The locking elements 1564, 1566 can assist, for example, in holding the release pin 1542 and the bushing 1544 in an engaging configuration. The locking element 1566 may be a slot formed on the inner surface of the bushing 1544, and the locking element 1564 may be a tab or protrusion of a size formed on the release pin 1542 and accepted within the corresponding slot 1566. It may be there. Alternatively, tab 1564 may be formed on the bushing and slot 1566 may be formed on the release pin. Tab 1564 prevents the release pin from inadvertently moving with respect to the bushing when it is accepted into slot 1566, and also allows the release pin to be manually removed from the bushing when the user so desires.
With reference to FIG. 47, the drive screw 1538 can include a lumen 1568, a distal portion 1570, and a proximal portion 1572. Lumen 1568 can extend from the distal portion 1570 of the drive screw 1538 to the proximal portion 1572 of the drive screw 1538.
The cavity 1568 of the drive screw 1538 and / or the actuating tube 1530 allows the actuating tube 1530 to extend through the lumen 1568, and the actuating tube 1530 is rotatable and axially movable with respect to the drive screw 1538. It can be of the same size and configuration.
The distal portion 1570 of the drive screw 1538 is configured to engage the corresponding thread (eg, female thread) of the mode selector button 1546, as further described below (eg, male). Can be equipped with screws).
The proximal portion 1572 of the drive screw 1538 may be coupled and secured to the actuating knob 1512. As such, the movement of the actuating knob 1512 (eg, rotational and axial) can result in the corresponding movement of the drive screw 1538. In some embodiments, the actuating knob 1512 may be coupled and secured to the drive screw by fasteners (eg, set screw), adhesive, and / or other means for fastening. In other embodiments, the actuating knob 1512 may be coupled and secured to the drive screw 1538 by integrally forming the actuating knob 1512 and the drive screw 1538 as a single unit component.
The release knob 1540 may be coupled and secured to the proximal end portion of the actuating tube 1530. As such, a movement of the release knob 1540 (eg, rotational and / or axial) can result in a corresponding movement of the actuating tube 1530. In some embodiments, the actuating knob 1512 may be coupled and secured to the drive screw 1538 by a fastener (eg, a set screw), an adhesive, and / or other means for fastening.
With reference to FIG. 52, the mode selector button 1546 can have an opening 1574. The opening 1574 is oval and may be configured to receive the drive screw 1538. The annular surface defining the opening 1574 may have a first portion 1576 (ie, the upper portion of the orientation shown) and a second portion 1578 (ie, the lower portion of the orientation shown). it can. The first part 1576 can be generally smooth. The second portion 1578 may have threads (eg, female threads) that are configured to engage the corresponding threads of the distal portion 1570 of the drive screw 1538, as shown in FIG. 53A. it can. The opening 1574 of button 1546 has the threads of the second part 1578 of button 1546 on the drive screw 1538 when the first part 1576 of button 1546 comes into contact with the drive screw 1538, as shown in Figure 53B. It can be sized and configured to engage and disengage from the threads. This configuration allows relative movement (eg, axial) between the button 1546 and the drive screw 1538, as described further below.
Referring to FIGS. 46-47, the anchor actuating mechanism 1508 of the handle 1500 sets the bushing 1544 to the working cavity 1526 of the housing 1506 so that the ear 1580 (FIG. 49) of the bushing 1544 extends from slot 1534 of the housing 1506. Can be assembled by inserting inside. In this way, slot 1534 of the housing 1506 allows the relative axial movement of the bushing 1544 within the working lumen 1526 of the housing 1506 and limits the relative rotational movement between the bushing 1544 and the housing 1506. Can act as a track or guide for 1544. In some embodiments, the bushing 1544 corresponds to a mating feature (eg, rail 1586 and /) of the working lumen 1526 of the housing 1506 to limit the relative rotational movement between the bushing 1544 and the housing 1506. Alternatively, it may have additional mating features (eg, slot 1582 and / or tab 1584 (FIG. 49)) that can be engaged with the notch 1588 (FIG. 54).
The urging member 1548 may be positioned within the bore 1536 of the housing 1506, and the mode selector button 1546 may be disposed on and within the bore 1536 of the urging member 1548. The button 1546 can then be pushed inward with respect to the bore 1536 of the housing 1506 so that the opening 1574 of the button 1546 is radially aligned with the working lumen 1526 of the housing 1506 (outside the urging member 1548 over the button 1546). Overcome the power of direction).
In this configuration, the drive screw 1538 may be inserted into the working cavity 1526 of the housing and passed through the opening 1574 of the button 1546 so that the distal end portion 1570 of the drive screw 1538 hits the bushing 1544. Get in touch.
The actuating tube 1530 is such that the release knob 1540 abuts on the actuating knob 1512 and the flange 1550 of the actuating tube 1530 extends distally from the lumen 1568 of the drive screw 1538 into the first opening 1556 of the bushing 1544. It can be inserted into the lumen 1568 of the drive screw 1538 so as to extend to. The release pin 1542 may be inserted into the second opening 1558 of the bushing 1544, so that the tab 1560 of the release pin 1560 engages with the flat portion 1554 of the flange 1550. It fits. Therefore, if the release pin 1542 is engaged, the actuating tube 1530 cannot rotate with respect to the bushing 1544 or housing 1506. Also, the actuating shaft 1530 and drive screw 1538 move together in the axial direction. This is because the actuating shaft cannot move proximally with respect to the drive shaft 1538 due to the bushing 1544 (which cannot extend into the cavity 1568 of the drive screw 1538), and the actuating shaft extends beyond the release knob 1540 (actuating knob 1512). Because it cannot be present), it cannot move distally with respect to the drive shaft 1538. However, the drive screw 1538 can rotate with respect to the actuating shaft 1530.
After assembly (eg, FIG. 46), the anchor actuating mechanism 1508 can operate in rotational and sliding modes. The default mode of operation is rotation mode because the urging member 1548 urges the threaded second part 1578 of the mode selector button 1546 against the thread of the drive screw 1538 (see, eg, Figure 53A). is there.
In an alternative embodiment, the mode selector button 1546 may be configured such that the default mode of operation is the sliding mode. This can be achieved, for example, by switching the placement of the threaded portion 1578 and the smooth portion 1576 of button 1546.
In rotation mode, the anchor of the prosthetic spacer device can be actuated by rotating the actuating knob 1512 with respect to housing 1506. This moves the drive screw 1538 axially with respect to button 1546. As the drive screw 1538 moves axially, the drive screw 1538 carries along with it the actuating tube 1530 (and the actuating shaft 512 that can be coupled to the actuating tube 1530). Also, the release pin 1542 moves axially with respect to slot 1532 and the bushing 1544 moves axially with respect to the working lumen 1526.
Rotating the actuating knob 1512 in a first direction (eg, clockwise) with respect to housing 1506 can result in the anchor of the prosthetic spacer device opening or expanding away from the spacer body. Rotating the actuating knob 1512 in a second direction (eg, counterclockwise) with respect to housing 1506 may result in the anchor of the prosthetic spacer device closing or folding towards the spacer body.
To switch from rotary mode to sliding mode, the user can press the mode selector button 1546 inward with respect to the housing 1506. This movement disengages the thread of button 1546 from the thread of drive screw 1538, thereby opening or activating the anchor of the prosthesis spacer device by the user pushing the actuation knob 1512 distally with respect to the housing 1506. It is possible to close the anchor of the prosthesis spacer device by pulling the knob 1512 proximally with respect to the housing 1506.
Due to the dual / hybrid operating mode, the handle 1500 offers several significant advantages. For example, the handle 1500 allows the user to make both quick and / or coarse adjustments of push / pull operations and precision and / or fine adjustments of rotational operations. The handle 1500 also allows the actuating shaft 512 to be moved with respect to the housing 1506 without the user rotating the actuating knob 1512 and / or pressing the mode selector button 1546 to move the actuating knob 1512 axially. Since it is impossible, a locking mechanism is realized in any operation mode.
To release the actuating shaft from the prosthetic spacer device, the user can pull the release pin 1542 out of the actuating tube 1530, bushing 1544, and slot 1534. This allows the user to rotate the release knob 1540 (eg, counterclockwise) with respect to the housing 1506, which results in the actuating tube 1530 and actuating shaft rotating with respect to the housing 1506 and the prosthetic spacer device. It will be. It allows the actuating shaft to be retracted from the distal collar of the prosthetic spacer device. The release knob 1540 is then moved proximally with respect to housing 1506 to pull the actuating shaft out of the prosthetic spacer device and coupler 514 of the outer shaft 520, whereby the prosthetic spacer device can be released from the delivery device.
In some embodiments, the release knob 1540 and release pin 1542 may be of the first color (eg, blue), the actuating knob 1512 may be of the second color (eg, black), and the mode selector button. 1546 may be a third color (eg gray). This is, for example, a visual indicator to the user that the release knob 1540 and release pin 1542 are involved (ie, because they are the same color), as well as the actuation knob 1512, release knob 1540, and mode selector button. The 1546 can provide a visual indicator that it performs different functions (ie, because they are different colors).
In addition, or alternatives, the release knob 1540 and release pin 1542 are lettered (eg, "Release"), symbols (eg, locked) to make the component easier to use and / or intuitive to use. It can have no key) and / or other indicators or features such as texture (eg ribs). Similarly, the mode selector button 1546 and / or actuation knob 1512 may have one or more such indicators or features.
The clasp control mechanism 1510 of the handle 1500 may have a configuration similar to the clasp control mechanism 550 described above.
55-61D show an exemplary embodiment of the handle 1600 and its components. Handle 1600 can be used, for example, with a third catheter 508 of delivery device 502 instead of handle 522. Referring to FIG. 55, the handle 1600 has five main components: a connecting member 1602, a flushing mechanism (not shown), a housing 1604, an anchor actuating mechanism 1606, and a clasp actuating mechanism 1608.
The handle 1600 has a configuration similar to that of the handle 1500. The anchor actuating mechanism 1606 of the handle 1600 allows the user to move the actuating knob 1610 of the anchor actuating mechanism 1606 axially (ie, distal / proximal) and rotationally move the actuating knob 1610, as further described below. (Ie, clockwise / counterclockwise) is configured to allow the anchor of the prosthesis spacer device (eg, anchor 204) to be actuated. In this way, the anchor actuation mechanism 1508 realizes hybrid anchor actuation (eg, similar to the handle 1500).
The housing 1604 of the handle 1600 can include a nose portion 1612, a main body portion 1614, and a support portion 1616. The distal end of the nose portion 1612 may be coupled to the connecting member 1602 and / or the outer shaft 520, and the proximal end of the nose portion 1612 may be coupled to the distal end of the body portion 1614. The support portion 1616 may be coupled to the proximal end of the body portion 1614.
The nose portion 1612, body portion 1614, and support portion 1616 of housing 1604 may include working lumens (not shown). The nose portion 1612 and the body portion 1614 may also include multiple (eg, two) clasp control lumens (not shown).
The body portion 1614 of housing 1604 can have a substantially cylindrical or substantially round shape. The cylindrical shape can allow, for example, the handle 1600 to be placed on or fixed to an object (eg, a table) in any rotational orientation (eg, when rotating the outer shaft 520). it can. The cylindrical shape can also help maintain its rotational orientation with respect to the object as the handle 1600 does not have a flat side to pivot or drip the handle.
The support portion 1616 of housing 1604 can have a substantially rectangular shape. In some embodiments, the edges of the support portion 1616 are rounded and can have a radius similar to the radius of the body portion 1614.
With reference to FIG. 56, the support portion 1616 of housing 1604 may include a slot 1618 extending from the working lumen. Slot 1618 may be configured to receive release pin 1622 and / or bushing 1624 of actuation mechanism 1606 (eg, similar to slot 1534 of handle 1500). The support portion 1616 may also include a bore 1620. The bore 1620 may be configured to receive the mode selector button 1626 and the urging member (eg, spring) 1628 of the actuating mechanism 1606.
Referring to FIG. 56, the actuating mechanism 1606 of the handle 1600 includes an actuating tube 1630, a drive screw 1632, an actuating knob 1610, a release knob 1634, a release pin 1622, a bushing 1624, and a mode selector button 1626. It can be equipped with a force element 1628. The actuating mechanism 1606 can be constructed, assembled and operated in the same manner as the actuating mechanism 1508 similar to the handle 1500. For example, FIGS. 57-59 show detailed views of the actuating tube 1630, bushing 1624, and distal portion 1636 of the release pin 1622, respectively. FIG. 60 shows the distal portion 1636 of the working tube 1630 coupled to the bushing 1624 by the release pin 1622. FIG. 55 shows the entire actuation mechanism 1606 assembled and coupled to housing 1604.
Referring to FIG. 55, the clasp control mechanism 1608 of the handle 1600 can include a clasp tube 1638, an actuator 1640, and a locking member 1642. In an exemplary embodiment, there are two tubes, a clasp tube 1632, two actuators 1640, and two locking members 1642. In other embodiments, clasp control mechanism 1608 can have more (eg, 3) or less (eg, 1) tubes, actuators, and locking members.
Each distal end portion of the clasp tube 1638 may be disposed within its respective control lumen of the body 1614 and may be axially movable with respect to it. Each proximal end portion of clasp tube 1638 may be coupled to its respective actuator 1640. Each of the locking members 1642 (eg, stopcock) can be coupled to its respective actuator 1640. The clasp control member 524 (FIG. 15) can extend through the clasp tube 1638 and can be releasably secured to the actuator by a locking member 1642.
Actuators 1640 may be selectively coupled together, for example, by removable pins 1644. As such, the actuator 1640 can be moved together to actuate the clasp control member 524 (and thus the clasp 206 of the prosthetic spacer device) at the same time as the pin 1644 is inserted into the actuator 1640. Actuators 1640 (clasp 206) can be moved individually when pin 1644 is removed.
With reference to FIG. 61A, in some embodiments, each of the actuators 1640 is disposed on the surface of the actuator 1640 facing the support portion 1616 of the housing 1604 and / or a holding member extending from it (eg, eg). , Pin) can have 1646. The retaining member 1646 may be configured to engage the support portion 1616 of the housing 1604 to hold the relative position of the actuator 1640 and the housing 1604, and then to hold the clasp positioning of the prosthesis spacer device.
In some embodiments, the holding member 1646 can be sized and / or configured to position the clasp tube 1638 slightly off-axis with respect to the control lumen of housing 1604. In this way, the clasp tube 1638 acts as an urging member that presses the holding member 1646 against the support portion 1616. This force results in a frictional engagement between the clasp tube 1638 and the support portion 1616, which reduces the possibility of the actuator 1640 being inadvertently moved with respect to the support portion 1616. Friction engagement also helps maintain the prosthetic device's clasp position in the open position by overcoming the tensile forces on the clasp control member and actuator caused by urging the clasp towards the closed position.
In other embodiments, the holding member 1646 can be sized and / or configured to position the clasp tube 1638 coaxially with the control lumen of the housing 1604, and the support portion 1616 of the housing 1604 is an actuator 1640. One or more retaining elements (shown in FIGS. 61A-61D, respectively, and generally referred to as "retaining element 1648", which are disposed on and / or extend from the surface of the support portion 1616 facing. / Or can have holding elements 1648a, 1648b, 1648c, and 1648d, which are collectively referred to). The retaining element 1648 may be configured to engage the actuator 1640 and / or the retaining member 1646 to hold the relative position of the actuator 1640 and the housing 1604, and then to hold the clasp positioning of the prosthesis spacer device.
FIG. 61A shows an exemplary holding element 1648a. The holding element 1648a comprises a protrusion or ridge extending and / or engaging with the holding member 1646 of the actuator 1640. Therefore, in order for the actuator 1640 to move with respect to the housing 1604, the holding member 1646 must be moved onto the holding element 1648a. As the retaining member 1646 moves onto the retaining element 1648a, the clasp tube 1648 is pushed slightly off-axis with respect to the control lumen of the housing, thereby increasing the frictional engagement between the control lumen and the clasp tube 1638. This then makes it relatively difficult to move the actuator 1640 with respect to the housing 1604. To open the clasp on the prosthetic spacer device, actuator 1640 is moved to its most proximal position (as shown in Figure 61A). The engagement between the holding member 1646 and the holding element 1648a resists the movement of the actuator 1640 under the tensile force of the clasp, thereby holding the clasp in its open position. To close the clasp, the user can push the actuator 1640 distally (to the left in FIG. 61A) with sufficient force to push the holding member 1646 onto the holding element 1648a. If desired, the user can lift the actuators slightly away from the support portion 1616, pushing them distally so that the holding member 1646 can remove the holding element 1648a.
FIG. 61B shows, for example, another exemplary holding element 1648b that can be used in place of holding element 1648a. The retaining element 1648b has a distal portion with a relatively gentle slope and a proximal portion with a relatively steep slope. The steeply tilted proximal portion of the retaining element 1648b can act as a lock to selectively hold the retaining member 1646 (and thus the actuator 1640) in its most proximal position. Actuator 1640 has sufficient distal force (and / or) to allow the retaining member 1646 to "climb" the proximal portion of the steep slope of the holding element 1648b and move onto the distal portion of the gently tilting of the holding element 1648b. It can be moved from its most proximal position by applying a normal force) to the actuator 1640. After the retaining member 1648 passes through the apex of the retaining element 1648b, the actuator tends to move relatively easily in the distal direction due to the gently tilted distal portion (and the tension on the clasp control member 524). The actuator 1640 is proximal to the actuator 1640 with sufficient force for the retaining member 1646 to "climb" the distal portion of the holding element 1648b with a gentle slope and move onto the proximal portion of the holding element 1648b with a steep slope. It can be moved to the most proximal position by moving to. The force required to move the actuator 1640 proximally over the distal portion of the holding element 1648b is the actuator 1640, as the gently tilted portion does not change much more abruptly than the steeply tilted portion. It is relatively less noticeable (ie, seems easier) to the user than the force required to move the retaining element 1648b distal to the proximal portion. This is in contrast to the retaining element 1648a shown in FIG. 61A, which has similar tilts on the proximal and distal sides of the retaining element 1648a.
FIG. 61C shows, for example, another exemplary holding element 1648c that can be used in place of holding elements 1648a, 1648b. The retaining element 1648c has a distal portion with a relatively gentle slope and a proximal portion with a relatively steep slope. The proximal portion of the retaining element 1648c has a slope substantially similar to the tilt of the proximal portion of the retaining element 1648b (FIG. 61B). The distal portion of the retaining element 1648c has a tilt that is even more gentle than the tilt of the distal portion of the retaining element 1648b shown in FIG. 61B.
FIG. 61D shows yet another exemplary holding element 1648d that may be used in place of, for example, holding elements 1648a, 1648b, 1648c. The retaining element 1648d has a wall or lip that extends perpendicular to the proximal side and a relatively steeply inclined portion to the distal side. As such, in order to move the actuator 1640 distally, the user lifts the actuator 1640 over the holding element 1648d and moves it distally, causing the clasp to move from its open configuration to the closed configuration. It can be possible. In this way, the vertical lip portion of the holding element 1648d can reduce the possibility of the actuator being inadvertently moved distally compared to the holding elements 1684a, 1684b, and / or 1684c.
In some embodiments, the holding element 1648 may be configured and / or positioned to hold the actuator 1640 near the proximal end of the support portion 1616. This can help, for example, to hold the clasp of the prosthetic spacer device in an open configuration.
In some embodiments, the support portion 1616 can have multiple holding elements 1648 in various arrangements along the length of the support portion. For example, the first holding element may be positioned near the proximal end of the support (eg, holding the actuator 1640 in its most proximal position and holding the clasp in its open configuration). The second holding element may be positioned near the distal end of the support portion (eg, holding the actuator in the most distal position and holding the clasp in its closed configuration).
62-75 show an exemplary embodiment of the handle 1700 and its components. The handle 1700 can be used, for example, in place of the handle 522 with a third catheter 508 of delivery device 502 to position, secure, and / or deploy the prosthetic spacer device. With reference to FIG. 62, the handle 1700 is a connecting member (sometimes referred to as a tension relief material) 1702, housing 1704, anchor actuating mechanism 1706, clasp actuating mechanism 1708, and flushing mechanism 1710 (partially in FIG. 63). (Shown), has 5 main components.
The handle 1700 is configured and functions in a manner generally similar to the handles 1500 and 1600. The anchor actuating mechanism 1706 of the handle 1700 allows the user to either press / pull the actuating knob 1712 of the anchor actuating mechanism 1706 while pressing the mode selector button 1714, or rotate the actuating knob 1712 without pressing the mode selector button 1714. It is configured to allow the anchor of the prosthetic spacer device (eg, anchor 204 of the prosthetic spacer device 200) to be activated. In this way, the anchor actuation mechanism 1706 realizes hybrid anchor actuation (eg, similar to the handle 1600).
The housing 1704 of the handle 1700 can include a body portion 1716 and a support portion 1718. The distal end of body portion 1716 may be coupled to connecting member 1702 and / or outer shaft 520. The body portion 1716 can have a first portion 1716a (ie, the upper portion of the orientation shown in FIG. 62) and a second portion 1716b (ie, the lower portion of the orientation shown in FIG. 62). The support portion 1718 may extend from the proximal end of the body portion 1716 (eg, from the second portion 1716b of the body portion 1716). The support portion 1718 can have a first portion 1718a (ie, the upper portion of the orientation shown in FIG. 62) and a second portion 1718b (ie, the lower portion of the orientation shown in FIG. 62).
In some embodiments, one or more parts of the body 1716 and / or one or more parts of the support 1720 are integrally formed (eg, molded) as a single unit component, or It can be formed as separate components that are joined together (eg, by fasteners, frictional engagements (eg tabs), adhesives, welds, and / or other means for fastening). For example, as shown in FIGS. 62-63, the second portions 1716b, 1718b, and support portion 1718 of the main body 1716 may be integrally formed, and the first portion 1716a and the second of the main body 1716 may be integrally formed. The parts 1716b may be joined together by fasteners (eg, screws 1720), and the first and second parts 1718a and second parts 1718b of the support part 1718 are joined together by fasteners (eg, screws 1720). You can. In other embodiments, the first portion 1716a and the second portion 1716b of the body portion 1716 may be integrally formed.
With reference to FIGS. 64-65, the handle 1700 may further comprise various components disposed and / or coupled within the housing 1704. For example, in some embodiments, the handle 1700 may optionally include coupling member 1722, stabilizer member 1724, and / or shaft guide member 1726.
Referring to FIGS. 66-67, the coupling member 1722 includes a shaft portion 1728, a flange portion 1730 extending radially outward from the shaft portion 1728, and a shaft portion from the distal end to the proximal end of the coupling member 1722. It can have a lumen 1732 extending axially through 1728. In some embodiments, the shaft portion 1728 may have a protruding or raised portion 1734 that extends radially outward.
As shown in FIG. 64, the connecting member 1702 may extend partially over the shaft portion 1728 of the connecting member 1722, and the ridge 1734 helps prevent relative movement between them. be able to. Flange portion 1730 may be configured to connect the coupling member 1722 to housing 1704 (eg, by fasteners 1736). The outer shaft 520 may extend within the distal end portion of lumen 1732, and the actuating shaft 512 and clasp control member 524 may extend from the proximal end of the outer shaft 520 and lumen 1730. ..
In some embodiments, the coupling member 1722 can have a partition 1738 that divides the lumen 1732 into multiple segments. Partition 1738 may be located within the proximal end portion of lumen 1732. In an exemplary embodiment, the partition 1738 has a substantially "Y-shaped" shape, thus dividing lumen 1732 into three segments 1732a, 1732b, 1732c. For example, segment 1732a may be configured to receive one of clasp control members 524, and segment 1732b may be configured to receive another of clasp control member 524. Often, the segment 1732c may be configured to receive the actuating shaft 512.
In certain embodiments, partition 1738 orients the outer shaft 520 (and thus the prosthetic spacer device attached to the distal end portion of the outer shaft 520) with respect to the coupling member 1722 (and thus the handle 1700) in a predetermined rotational orientation. Can be configured as This can be achieved by positioning the axis 1733 of the partition 1738 at an angle θ with respect to the axis 1735 of the coupling member 1722. The angle θ between axes 1733 and 1735 may be in the range 0-360 degrees. In some embodiments, the angle θ between axes 1733 and 1735 may be in the range 15-90 degrees. In one particular embodiment, the angle θ between axes 1733 and 1735 may be about 45 degrees. The coupling member 1722 aligns a pair of clasp-controlled lumens of the outer shaft (see, eg, lumens 1304a-1304d of the outer shaft 1300 shown in FIG. 41) with segments 1732a, 1732b of the coupling member 1722, respectively. Can be coupled to the outer shaft of the third catheter. The coupling member 1722 may be coupled to the shaft guide member 1726 and housing 1704 along with the outer shaft. Since the coupling member 1722 can only be coupled to the shaft guide member 1726 and the housing 1704 in one rotational orientation (eg, due to its asymmetrical shape), the rotational orientation of the coupling member 1722 makes the outer shaft rotational orientation with respect to the handle 1700. It is decided in this way.
The predetermined orientation between the outer shaft and the handle 1700 is spontaneous anatomical, for example, when the prosthetic spacer device is coupled to the outer shaft 520 and advanced through the patient's vasculature to reach an implant placement. The prosthetic spacer device may be selected to rotateably align with respect to the structure (eg, via angle θ). For example, for a delivery assembly configured to implant a prosthetic spacer device at the patient's natural mitral valve via a transseptal delivery approach (eg, prosthetic spacer device 200 with handle 1700 and delivery device 502). Partition 1738 can be oriented at an angle θ of about 45 degrees as shown in FIG. When oriented in this way, the prosthetic spacer device is a prosthetic spacer device when the prosthetic spacer device is deployed from sheath 518 and positioned coaxially with the mitral valve (see, eg, FIGS. 20-23). The anchor is oriented with respect to the natural anatomical structure so that it is at least substantially rotatably aligned with the natural valve leaflet of the mitral valve, and the handle 1700 has the clasp actuation mechanism pointing upwards (eg, shown in Figure 62). Rotatably oriented (in orientation).
This can reduce, for example, the time a doctor spends aligning a prosthetic spacer device when performing an implantation procedure. It can also improve the efficiency and accuracy of the manufacturing process by reducing the amount of guesswork required to orient the outer shaft 520 with respect to the coupling member 1722.
The partition 1738 provides hemostasis between the outer shaft 520 and the handle 1700, for example, by reducing leakage at the joint between the sleeve 1740 (Fig. 65) (extending through the clasp control member) and the outer shaft 520. Sealing can also be improved.
As shown in FIG. 65, the stabilizer member 1724 may be attached to the distal end portion of the shaft guide member 1726 by fasteners, adhesives, and / or other connecting means (eg, tab 1739). .. Stabilizer member 1724 can include support portions 1741 that are spaced apart from the proximal end of the outer shaft 520 (FIG. 64) and the port 1743 at the distal end portion of the shaft guide member 1726. Stabilizer member 1724 may also include an opening 1742 through which the actuating shaft 512 and its sleeve 1744 may extend. In this way, the stabilizer member 1724 can support, for example, a portion of the actuating shaft 512 and a sleeve 1744 disposed between the outer shaft 520 and the shaft guide member 1726. As such, the stabilizer member 1724 can reduce, for example, buckling or kinking that occurs in the actuating shaft 512 when actuating the anchor actuating mechanism 1706. This in turn improves the functionality and / or reliability of the anchor actuation of the anchor actuation mechanism 1706 and thus the prosthetic spacer device.
Note that the stabilizer member 1724 and partition 1738 are not shown in Figure 64 for the sake of clarity of the other components of the handle 1700.
The shaft guide member 1726 can include clasp control lumens 1746 (eg, two in the illustrated embodiments), actuating shaft lumens 1748, and flushing lumens 1750. The clasp control member 524 may extend through the clasp control lumen 1746 and may be coupled to the clasp control mechanism 1708. The actuating shaft 512 may extend through the actuating shaft lumen 1748 and may be coupled to the anchor actuating mechanism 1706. The flushing lumen 1750 can be coupled to the first portion 1752 of the flushing tube (FIG. 64) and the second portion 1754 of the flushing tube (FIG. 63) of the flushing mechanism 1710 (FIG. 63).
The anchor actuating mechanism 1706 may be coupled to the actuating shaft 512. As mentioned above, the anchor actuating mechanism 1706 of the handle 1700 either pushes / pulls the actuating knob 1712 of the anchor actuating mechanism 1706 while the user holds down the mode selector button 1714, or presses the mode selector button 1714. It is configured to allow the actuating shaft 512 and thus the anchor of the prosthetic spacer device to be actuated by rotating the actuating knob 1712 without.
Referring to FIG. 62, while starting from the proximal end of the handle 1700 and moving towards the distal end, the anchor actuating mechanism 1706 has a release knob 1756, an actuating knob 1712, a drive shaft 1758, and a mode. It may have a selector button 1714 and a release pin 1760. With reference to FIGS. 68-69, the anchor actuating mechanism 1706 (FIG. 62) is coupled to the distal and proximal actuating sleeves 1762, 1764 and the sleeves 1762, 1764, respectively, with the ferrule 1766 extending between them. Can also be provided. As shown in FIG. 69, the actuating shaft 512 may extend through sleeves 1762, 1764 and ferrule 1766 and be coupled and secured to them. In this way, the actuating shaft 512, sleeves 1762, 1764, and ferrule 1766 together perform both axial and rotatable movements. With reference to FIG. 75, the anchor actuating mechanism 1706 may also include a bushing 1768. The components and operation of the actuating mechanism are further described below.
With reference to FIG. 62 again, the proximal end portion 1758a of the drive shaft 1758 may be disposed outside the housing 1704, and the actuating knob 1712 may be coupled and secured to it. The drive shaft 1758 can extend through the proximal opening 1770 of housing 1704. Then referring to FIG. 75, the drive shaft 1758 extends through the opening of the mode selector button 1714 (not shown, but see, for example, the opening 1574 of the mode selector border 1546 shown in FIG. 52). It can extend through the opening 1772 of the bushing 1768. The distal end portion 1758b of the drive shaft 1758 may be coupled to the bushing 1768 so that the drive shaft 1758 can rotate with respect to the bushing 1768 but cannot move axially with respect to the bushing 1768. This can be achieved, for example, by connecting the distal end portion 1758b of the drive shaft 1758 to the bushing 1768 by fasteners (eg, C-clip 1774) on the distal and proximal sides of the bushing 1768.
As shown in FIG. 62, the drive shaft 1758 may include a threaded portion 1776. The mode selector button 1714 (movably coupled to the housing 1704) now screwably engages with the threaded portion 1776 of the drive shaft 1758 when the mode selector button 1714 is in the first mode of operation. It can be provided with a threaded portion that is configured. In the first mode of operation, the drive shaft 1758 can be moved axially with respect to the mode selector button 1714 by rotating the actuating knob 1712 with respect to the housing 1704. In an exemplary embodiment, the threaded portion of the drive shaft 1758 and the mode selector button 1714 are "left" screws. As such, when the drive shaft 1758 is rotated clockwise with respect to the mode selector button portion 1714, the drive shaft 1758 moves proximally with respect to the housing 1704 and the drive shaft 1758 counterclockwise with respect to the mode selector button portion 1714. When rotated, the drive shaft 1758 moves distally with respect to housing 1704. In other embodiments, the threaded portion of the drive shaft 1758 and the mode selector button 1714 may be "right" threads. In those embodiments, rotating the drive shaft 1758 counterclockwise with respect to the mode selector button portion 1714 causes the drive shaft 1758 to move proximally with respect to the housing 1704 and the drive shaft 1758 clockwise with respect to the mode selector button portion 1714. When rotated, the drive shaft 1758 moves distally with respect to housing 1704.
The mode selector button 1714 may also include a non-threaded portion that is configured to engage the drive shaft 1758 when the mode selector button 1714 is in the second mode of operation. In the second mode of operation, the drive shaft 1758 can be moved axially with respect to the mode selector button 1714 by pushing or pulling the actuating knob 1712 with respect to the housing 1704. The mode selector button 1714 may be urged to either the first or second mode of operation as the default mode of operation (eg, by a urging member such as a spring), and the mode selector button 1714 may be pressed. You can move from the default operating mode to another operating mode by pressing.
Keeping the openings of the drive shaft 1758 and mode selector button 1714 coaxially as the drive shaft 1758 moves axially with respect to the mode selector button 1714 in both the first and second mode of operation. The bushing 1768 and housing 1704 can be provided with their respective fitting features to help. For example, in an exemplary embodiment, the bushing 1768 comprises a tab or protrusion 1778 that can be disposed within each slot of the housing 1704, as shown in FIG. 75. The tab 1778 and bushing 1704 slots of the bushing 1768 allow the bushing 1768 and therefore the drive shaft 1758 to move axially with respect to the housing 1704 and the mode selector button 1714, laterally between them (eg, in Figure 75). Prevents left / right movement in the orientation shown and vertical movement (eg, up / down in the orientation shown in FIG. 75). As a result, the bushing 1768 helps keep the drive shaft 1758 and the opening of the mode selector button 1714 coaxial. Maintaining coaxiness can, for example, reduce or prevent the drive shaft 1758 from binding with respect to the mode selector button 1714, and / or promote smooth, controllable movement between components.
With reference to FIG. 62, the proximal end portion 512a (FIG. 15) and / or the proximal sleeve 1764 (FIG. 69) of the actuating shaft 512 may be secured to the release knob 1756 (eg, with fasteners, glue, etc.). .. As best shown in FIG. 71, the drive shaft 1758 can have an axially extending lumen 1780 through which the actuating shaft 512, sleeves 1762, 1764, and ferrule 1766 can be extended. .. The lumen of the drive shaft 1758 can be sized and / or configured such that the actuating shaft 512, sleeves 1762, 1764, and ferrule 1766 are movable (eg, rotatable, axial) with respect to the drive shaft 1758. .. This can be achieved by forming a lumen 1780 of the drive shaft 1758 with a diameter of at least slightly larger than the diameter of the actuating shaft 512, sleeves 1762, 1764, and ferrule 1766. The proximal sleeve 1764 and drive shaft 1758 are shown when the distal end portion of the release knob 1756 is placed adjacent to or in contact with the proximal end portion of the actuating knob 1712 (eg, FIG. 62). As such), the ferrule 1766 (which is coupled to the distal end portion of the proximal sleeve 1764) can be sized to be disposed adjacent to the distal end portion 1758b of the drive shaft 1758.
From the ferrule 1766, the distal sleeve 1762 and the actuating shaft 512 may extend distally through the support portion 1718 of the housing 1704. As shown in FIGS. 64-65, the actuating shaft 512 extends distally through the actuating shaft lumen 1748 of the shaft guide member 1726 and can extend into the sleeve 1744. The sleeve 1744 and the actuating shaft 512 exit from port 1743 of the shaft guide member 1726, extend through the opening 1742 of the stabilizer member 1724, and through the actuating shaft lumen 538 (FIG. 16) of the outer shaft 520. Can be extended. As shown in FIG. 12, the distal end portion 512b of the actuating shaft 512 extends distally beyond the sleeve 1744, and the distal end portion 520b of the outer shaft 520, and the distal collar of the prosthetic spacer device 200. Can be screwed to 208.
With the actuating shaft 512 of the delivery device 502 coupled to the distal collar 208 of the prosthetic spacer device 200, the actuating shaft 512 may be releasably coupled to the anchor actuating mechanism 1706 via the release pin 1760. This can be achieved by inserting the release pin 1760 through the window portion 1782 of the support portion 1718 of the housing 1704 such that the release pin 1760 engages the ferrule 1766, as shown in FIG.
Referring to FIGS. 68-69, the release pin 1760 and ferrule 1766 perform relative movement (eg, rotatable and / or axial movement) between them as the release pin 1760 engages the ferrule 1766. It can be configured to interfere. For example, in some embodiments, the ferrule 1766 is a first recessed portion 1784 having a non-circular (eg, rectangular, hexagonal, etc.) cross-sectional outline taken in a plane perpendicular to the longitudinal axis of the ferrule. May be provided. The first recessed portion 1784 is sometimes referred to as the "flat portion". The release pin 1760 can have a first pair of jaws 1786 configured to define a non-circular first notch and engage the first recess 1784 of the ferrule 1766. .. The engagement between the non-circular surface of the release pin 1760 and the ferrule 1766 can prevent the relative rotational movement between the release pin 1760 and the ferrule 1766. The engagement between the first pair of jaws 1786 and the step 1788 of the ferrule 1766 can prevent the relative axial movement between the release pin 1760 and the ferrule 1766.
Still referring to FIGS. 68-69, the ferrule 1766 is optionally provided with a second recess 1790 having a circular cross-sectional outline taken in a plane perpendicular to the longitudinal axis of the ferrule. Good. Release pin 1760 has a second pair of jaws 1792 configured to optionally define a circular second notch and engage the second recess 1790 of the ferrule 1766. be able to. Thus, the engagement between the second pair of jaws 1792 and the step 1794 of the ferrule 1766 can prevent the relative axial movement between the release pin 1760 and the ferrule 1766. The circular configuration of the second pair of the second recess 1790 and the jaw 1792, for example, the surface area where the second pair of the jaw 1792 contacts the step 1794 of the ferrule 1766 is the first of the jaw 1786. The ability of the release pins 1760 and / or ferrule 1766 to withstand axial loads can be improved because the pair is relatively larger than the surface area in contact with the step 1788 of the ferrule 1766.
The release pin 1760 can also prevent relative rotational movement between the actuating shaft 512 and the housing 1704 when the release pin is coupled to the ferrule 1766. This is because the release pin 1760 is located in slot 1796 of the support portion 1718 of the housing 1704 defined by the surface 1798. If the user attempts to rotate the actuating shaft 512 through the release knob 1756, the release pin 1760 contacts the surface 1798 of the housing 1704 and prevents the release pin 1760 from rotating with respect to the housing 1704. Therefore, when the release pin 1760 is coupled to the ferrule 1766, the release pin 1760 prevents the release knob 1756 from rotating with respect to the housing 1704, which in turn prevents the actuating shaft 512 from being released from the prosthetic spacer device 200. Hinder.
The release pin 1760 and release knob 1756 prevent relative axial movement between the actuating shaft 512 and the drive shaft 1758 when the release pin 1760 is coupled to the ferrule 1766. This is because the release knob 1756 (which is coupled to the actuating shaft 512 via the proximal sleeve 1764) contacts the proximal end portion 1758a of the drive shaft 1758, thereby causing the actuating shaft 512 to be distal with respect to the drive shaft 1758. This is because it prevents movement, and the release pin 1760 (which is coupled to the actuating shaft 512 via the ferrule 1766) contacts the distal end portion 1758b of the drive shaft 1758, thereby causing the actuating shaft 512 to move. This is because it prevents the 1758 from moving proximally. As a result, the actuating shaft 512 moves axially with the drive shaft 1758 when the release pin 1760 is coupled to the ferrule 1766. Moving the drive shaft 1758 distally with respect to the housing 1704 causes the distal end portion 1758b of the drive shaft 1758 to be urged against the release pin 1760 and thus the actuating shaft 512 to move distally (eg, a prosthetic spacer device). Open 200 anchors 204). When the drive shaft 1758 is moved proximally with respect to the housing 1704, the proximal end portion 1758a of the drive shaft 1758 is urged against the release knob 1756 and thus the actuating shaft 512 is moved proximally (eg, prosthetic spacer device). Close the 200 anchor 204).
As the drive shaft 1758 and actuating shaft 512 move axially with respect to housing 1704, the release pin 1760 slides axially within slot 1796. In some embodiments, the release pin 1760 may be accessible to the user regardless of the axial position of the release pin 1760 with respect to the housing 1704. In such an embodiment, the user can remove the release pin 1760 from the ferrule 1766 at any time, whereby the actuating shaft 512 can move independently of the drive shaft 1758. This can be achieved, for example, by axially sizing the window portion 1782 so that the release pin 1760 is accessible to the user regardless of the axial position of the drive shaft 1758.
In other embodiments, the support portion 1718 of the housing 1704 is accessible to the user in one or more predetermined arrangements with respect to the release pin 1760 with respect to the housing 1704 and from the user in one or more other arrangements. It can be configured to be hidden. For example, in an exemplary embodiment, the release pin 1760 is accessible to the user (via the window 1782 of the housing 1704) and thus the actuating shaft 512 (via the drive shaft 1758), as shown in FIG. It is removable only when it is in one predetermined position with respect to the housing 1704. This is because the window 1782 is only slightly larger than the release pin 1760. When the actuating shaft 512 is in another axial position with respect to the housing 1704, the release pin 1760 is not aligned with the window 1782 and is therefore hidden from the user by the housing 1704, as shown in FIGS. 70-71. In some embodiments, the predetermined arrangement in which the release pin 1760 is accessible to the user may correspond to the most proximal position of the drive shaft 1758. This position of the drive shaft corresponds to the position of the actuating shaft 512 that causes the anchor 204 of the prosthetic spacer device 200 to be in a completely closed configuration (eg, FIG. 25). In such an embodiment, therefore, the housing 1704 allows the user to deploy the actuating shaft 512 from the prosthetic spacer device 200 (release pin 1760) before the anchor 204 of the prosthetic spacer device 200 is secured to the natural valve leaflet of the patient's heart. Acts as an additional safety measure to reduce the possibility of release (by pulling and rotating the release knob 1756).
Referring to FIG. 72, the clasp actuating mechanism 1708 comprises one or more clasp actuators 1701, one or more clasp tubes 1703, and one or more locking members 1705 (eg, stopcocks). be able to. For example, in an exemplary embodiment, there are two each of a clasp actuator 1701, a clasp tube 1703, and a locking member 1705. Each of these components is individually referred to as "17XXa" or "17XXb" (eg, first clasp actuator 1701a and second clasp actuator 1701b) and collectively referred to as "17XX" (eg, clasp actuator 1701). Will be done. As best shown in FIG. 62, the distal end portion of the clasp tube 1703 is movably coupled to the shaft guide member 1726 (FIG. 64) and is the body of the housing 1704 substantially parallel to the support portion 1718 of the housing 1704. It may extend proximally from 1716. The clasp actuator 1701 may be coupled and secured to the proximal end portion of the clasp tube 1703. The locking member 1705 may be coupled and secured to the clasp actuator 1701.
With reference to FIGS. 72 and 64-65, each of the clasp control members 524 (only those shown in FIG. 72 to show other features of the clasp actuator 1701) are from their respective clasp actuators 1701. It passes through the locking member 1705, through the lumen of the clasp actuator 1701 (not shown), through each clasp tube 1703, through each clasp control lumen 1746 of the shaft guide member 1726, and through each sleeve 1740. Extends through the respective lumen 540 (FIG. 16) of the outer shaft 520 and through the opening 238 (FIG. 15) of each clasp 206 of the prosthesis spacer device 200, and then follows approximately the same path but vice versa. Loops can be formed in the order of (but the ends of each clasp control member 524 pass through different lumens 540 of the outer shaft 520 as further described above) to the clasp actuator 1701.
The locking member 1705 can be used to secure the clasp control member 524 and its tension with respect to the clasp actuating mechanism 1708. As such, moving the clasp actuator distally reduces the tension on the clasp control member 524 (closes the clasp 206 of the prosthetic spacer device 200) and moves the clasp actuator proximally. Increase the tension on the clasp control member 524 (open the clasp 206 of the prosthetic spacer device 200).
With reference to FIG. 70, the clasp actuator 1701 can also include a holding member 1709 configured to engage a holding element 1711 disposed on the supporting portion 1718 of the housing 1704. The holding member 1709 and holding element 1711 may be configured to selectively hold the clasp actuator 1701 in a proximal position corresponding to the open position of the clasp 206 of the prosthetic spacer device 200. These features are used by the clasp 206, for example, by applying tension to the clasp control member 524 caused by the urging of the clasp 206 towards a closed position where the clasp actuator 1701 can be moved distally. It can help one to prevent accidental closure by accidentally pushing the clasp actuator 1701 distally.
The first clasp actuator 1701a and the second clasp actuator 1701b can be moved together (for example, when pin 1709 is inserted through the clasp actuator) or individually (for example, pin 1709). Can be selectively coupled together (eg, by pin 1713) as if they were removed from the clasp actuator.
In some embodiments, the support portion 1718 of the housing 1704 can also have a stopper 1715 disposed at the proximal end of the support portion 1718, as shown in FIG. 70. The stopper 1715 can, for example, restrict the movement of the clasp actuator 1701 in the proximal direction. With reference to FIG. 72, in some embodiments, the stopper 1715 can have an opening 1717 formed therein. The opening 1717 may be configured to accept and store pin 1713 as it is removed from the clasp actuator 1701 (eg, for separate clasp actuation).
The clasp actuator 1701 is also configured to secure the end of the clasp control member 524 to the clasp actuator 1701 and / or to release the end of the clasp control member 524 from the clasp actuator 1701 or A plurality of optional feature units can be provided. For example, as shown in FIG. 72, each clasp actuator 1701 has one or more protrusions 1731 with one or more ridges and / or channels extending through it, with a notch 1721 formed in it. Can have. One end of the clasp control member 524 can extend from each locking member 1705 through the channel of the protrusion 1731 and through the notch 1721. In this way, the channel and notch 1721 can act as a guide for the clasp control member 524. This may, for example, reduce the likelihood that the clasp control member 524 will become entangled with another component of the handle 1700 (eg, locking member 1705). Each clasp actuator 1701 can also have a plurality of spaced apart openings 1723 (eg, two in the illustrated embodiment) with struts 1707 placed between them. In this way, one end of each of the clasp control members 524 can be wound and secured (eg, tied) to the stanchions 1707 of the respective clasp actuator 1701.
The other end of each of the clasp control members 524 may extend from their respective locking members 1705 and may be coupled (eg, coupled) to pin 1713. Each of the clasp actuators 1701 can have an access point (eg, slot 1725) to access the respective clasp control member 524 to release it from the clasp actuator 1701. The access point may be located between the coupling arrangement (eg, opening 1723) and the locking member 1705. As a result, slot 1725 can provide an arrangement that allows the user to access and cut the clasp control member 524, for example, using a cutting tool such as a scalpel.
The clasp control member 524 may be secured to the clasp actuator 1701 and / or pin 1713 in a variety of other ways, including adhesives, clips, knots, and / or other fixing means.
Note that FIG. 72 illustrates only one clasp control member 524, which is coupled to the clasp actuator 1701a. This is to provide a clear illustration of the ridge 1719, notch 1721, opening 1723, and slot 1725 of the clasp actuator 1701b, which may also have another clasp control member 524 that is coupled and extends through. ..
73-75 show an exemplary embodiment of the clasp positioning tool 1800 used with the handle 1700 at the option. The clasp positioning tool 1800 can be used, for example, to allow the user to remove slack in the clasp control member and position the handle clasp actuating mechanism in place with respect to the handle anchor actuating mechanism while applying tension. As such, the clasp positioning tool 1800 can help ensure that tension in the clasp control member is consistently and precisely applied.
Although the clasp positioning tool 1800 is described herein as being used with the handle 1700, the clasp positioning tool 1800 is used with a variety of other handles, including handles 522, 700, 1500, and / or 1600. And / or may be adapted for use, and / or the handle may be adapted for use with the clasp positioning tool 1800.
Referring to FIG. 73, the clasp positioning tool 1800 can include a body 1802 and one or more protrusions 1804 (eg, two in the illustrated embodiment) extending from the body 1802. .. Generally speaking, the body 1802 may be configured to releasably couple the clasp positioning tool 1800 to the housing 1704 and position the anchor actuating mechanism 1706 with respect to the housing 1704, with the overhang 1804 being the clasp. The positioning tool 1800 may be releasably coupled to the clasp actuating mechanism 1708 and configured to position the clasp actuating mechanism 1708 with respect to the housing 1704.
The body 1802 of the clasp positioning tool 1800 can include a first opening 1806 formed on the side and a second opening 1808 formed on the proximal end. The first opening 1806 may be configured to provide access to the mode selector button 1714 on handle 1700, as shown in FIG. The second opening 1808 is provided so that the drive shaft 1758 of the anchor actuating mechanism 1706 can extend through and the actuating knob 1712 cannot extend through, as also shown in FIG. Can be configured. In this way, the body 1802 can restrict the movement of the actuating shaft 1758 distally when the actuating knob 1712 abuts on the proximal end of the body 1802 adjacent to the second opening 1808. it can.
With reference to FIG. 73 again, the body 1802 can include a lip or step 1810 that is spaced apart from the proximal end of the body 1802. The lip or step 1810 may be configured to engage the proximal end of the support portion 1718 of the housing 1704. Therefore, the lip portion 1810 can restrict the movement of the clasp positioning tool 1800 with respect to the housing 1704 in the distal direction.
With reference to FIG. 75, the body 1802 can also have one or more flange portions 1812 extending inward in the radial direction. Flange portion 1812 may be configured to releasably couple the clasp positioning tool 1800 to the handle 1700, as further described below.
The protrusion 1804 may extend outward from the flange portion 1812 of the body 1802 (eg, vertically in the orientation shown in FIG. 75). The protrusion 1804 may be configured to extend within the opening 1727 of the locking member 1705 of the clasp actuating mechanism 1708. In this way, the protrusion 1804 can restrict the movement of the clasp actuator 1701 with respect to the housing 1704 in the distal direction.
To provide access to the opening 1727 of the locking member 1705 of the handle 1700, the support portion 1718 of the housing 1704 may have a recess 1729 formed therein, as best shown in FIG. it can. The recess 1729 may be axially aligned with the window portion 1782 of the housing 1704.
The clasp positioning tool 1800 also aligns the opening 1727 (FIG. 63) of the locking member 1705 axially with the recess 1729 of the housing 1704 and the release pin 1760 to the housing 1704, as shown in FIG. 73. It can be coupled to the handle 1700 by moving the actuating mechanism 1706 distally so that it is not aligned with the window 1782. The protrusion 1804 of the clasp positioning tool 1800 can then be inserted into the opening 1727, as shown in FIG. The clasp positioning tool 1800 is proximal to the actuating mechanism 1706 so that the release pin 1760 is aligned with the window 1782 of the housing 1704 and thus with the flange 1812 of the clasp positioning tool 1800, as shown in FIG. Can be secured or locked to the handle 1700 (for example, for shipping) by moving to. In the locking configuration, the release pin 1760 locks the clasp positioning tool 1800 as the release pin 1760 closes one of the recesses 1729 of the housing 1704 and contacts one of the flanges 1812 of the clasp positioning tool 1800. Prevents removal from opening 1727 of member 1705. Although not shown, when the actuating knob 1712 is aligned with the window 1782, the actuating knob 1712 is spaced apart from the proximal end of the clasp positioning tool 1800.
As mentioned above, the handle 1700 may be part of a delivery device (eg, delivery devices 502, 1404), which together with a prosthetic spacer device (eg, prosthetic spacer devices 200, 1402). , At least part of the delivery assembly can be formed. An exemplary method of assembling the delivery assembly and using the handle 1700 and clasp positioning tool 1800 is described below.
The clasp control member 524 of the delivery device 502 can be coupled to the clasp 206 of the prosthetic spacer device 200 by looping the clasp control member 524 through the opening 234 of the clasp 206 (FIG. 15). The clasp control member 524 may be secured to the handle 1700 via a locking member 1705 and a clasp actuator 1701 (see FIG. 72). At this point, the clasp 206 of the prosthetic spacer device 200 can be opened and closed by moving the clasp actuator 1701 proximally and distally, respectively. The outer shaft 520 of the delivery device 502 may be coupled to the proximal collar 210 of the prosthetic spacer device 200 via the coupler 514 and actuation shaft 512 of the delivery device (see FIGS. 12-14). The actuating shaft 512 of the delivery device 502 inserts the distal end portion 512b of the actuating shaft 512 into the bore 226 of the distal collar 208 and inserts the release knob 1756 with respect to the prosthesis spacer device 200 (see FIGS. 14 and 62). It may be coupled to the distal collar 208 of the prosthesis spacer device 200 by rotating it in one direction (eg, clockwise). At this point, the anchor 204 of the prosthetic spacer device 200 can be opened and closed by moving the release knob 1756 distally and proximally, respectively.
With the delivery device 502 and the prosthetic spacer device 200 releasably coupled together, the actuating shaft 512 may be releasably coupled to the anchor actuating mechanism 1706 of the handle 1700. This can be achieved, for example, in at least some of the following actions: The actuating knob 1712 may be positioned such that the distal end portion 1758b of the drive shaft 1758 is located proximal to the window portion 1782 of the housing 1704 (see FIG. 62). This is done by rotating the actuation knob 1712 in the first direction (eg, clockwise) with respect to the housing 1704 and / or by pressing the mode selector button 1714 to move the actuation knob 1712 proximally with respect to the housing 1704. Can be achieved. The ferrule 1766 (coupled to the actuating shaft 512 and the release knob 1756) is exposed from the lumen 1780 of the drive shaft 1758 and positions the distal end of the release knob 1756 adjacent to the proximal end of the actuating knob 1712. This can be axially aligned with the window portion 1782 of the housing 1704. With the drive shaft 1758 and ferrule 1766 in this position, the release pin 1760 inserts the release pin 1760 through the window 1782 of the housing 1704 (see Figure 62) and ferrules the jaws 1786 and 1792 of the release pin 1760. It can be coupled to ferrule 1766 by urging over the recesses 1784, 1790, respectively, in 1766 (see Figure 68). With the release pin 1760 coupled to the ferrule 1766, the actuating shaft 512 (and thus the anchor 204 of the prosthetic spacer device 200) moves axially with the drive shaft 1758 of the anchor actuating mechanism 1706.
After the actuating shaft 512 is coupled to the anchor actuating mechanism 1706, rotate the actuating knob 1712 in a second direction (eg, counterclockwise) with respect to the housing 1704 and / or press the mode selector button 1714 to press the actuating knob 1712. Moving distally with respect to housing 1704 results in the anchor 204 moving towards the open configuration (see Figure 20). Rotating the actuating knob 1712 in the first direction (eg, clockwise) with respect to the housing 1704 and / or pressing the mode selector button 1714 to move the actuating knob 1712 proximally with respect to the housing 1704 results in the anchor 204 Move towards the closed position (see Figure 25).
The clasp positioning tool 1800 can be coupled and secured to the handle 1700 as described above (see Figures 73-75). An assembly comprising a delivery device, a prosthetic spacer device, and a clasp positioning tool 1800 may be packaged and / or delivered to the user in this configuration.
To prepare the delivery assembly for implantation, the user can remove the slack and / or adjust the tension of the clasp control member 524 with the clasp positioning tool 1800. This may be achieved by moving the drive shaft 1758 of the handle 1700 distally from its most proximal position, where the distal end of the actuation knob 1712 is the proximal end of the clasp positioning tool 1800. The release pin 1760 is axially aligned with the flange 1812 of the clasp positioning tool 1800 until it contacts the clasp positioning tool 1800 and is used to secure the clasp positioning tool 1800 to the handle 1700. This involves rotating the actuation knob 1712 in a second direction (eg, counterclockwise) with respect to the housing 1704 and / or pressing the mode selector button 1714 to move the actuation knob 1712 distally with respect to the housing 1704. Can be achieved by. This moves the anchor 204 of the prosthetic spacer device 200 from a fully closed configuration (eg, FIG. 25) to an open configuration that is at least partially open (eg, FIG. 23). When the anchor 204 is in this position, the user can open the locking member 1705 of the clasp actuating mechanism 1708 to remove the slack and / or adjust the tension of the clasp control member 524 in some other way. .. The user can then hold the desired tension on the clasp control member 524 by closing the locking member 1705, which prevents the clasp control member 524 from moving with respect to the clasp actuating mechanism 1708 of the handle 1700. Both first end portions of the clasp control member 524 can then be coupled (eg, coupled) to pin 1713 of the clasp actuating mechanism 1708 (see FIG. 72). Each of the second end portions of the clasp control member 524 positions the clasp control member 524 in the notch 1721, loops the clasp control member 524 through the opening 1723, and ties the clasp control member 524 to itself. Can be coupled to each clasp actuator 1701 by. By fixing the end of the clasp control member 524, for example, the risk of the clasp control member 524 being released from the clasp 206 can be reduced even when the locking member 1705 is opened. By separating the ends of each clasp control member 524 from each other (ie, by tying one end to the clasp actuator 1701 and the other end to the pin 1713), the clasp control member 524 can be easily cut (eg, release procedure). In).
The clasp positioning tool 1800 can be removed from the handle 1700 by pulling the protrusion 1804 of the clasp positioning tool 1800 out of the opening 1727 of the handle 1700 and removing the body 1802 from the housing 1704 of the handle 1700.
The flushing mechanism 1710 can be used to flush the delivery assembly (eg, with saline).
The prosthetic spacer device 200 can be positioned in the delivery configuration by moving the actuating knob 1712 and clasp actuator 1701 to the most distal positions. This extends the anchor 204 and closes the clasp 206 (see Figure 20).
The prosthetic spacer device 200, which is attached to the third catheter 508 (FIG. 11), is inserted into the first catheter 504 and the second catheter 506 (see FIG. 11) and placed in an implantation arrangement (see FIG. 20). Can be positioned adjacently. Catheter 504, 506, 508 (including handle 1700) can be used to position the prosthetic spacer device 200 with respect to the spontaneous heart valve apex (see FIGS. 20-22).
In an implantable arrangement, the handle 1700 anchor actuation mechanism 1706 is a prosthetic spacer device 200 between an extended delivery configuration (eg, FIG. 20), a positioning configuration (eg, FIG. 22), and a valve leaflet capture configuration (eg, FIG. 23). Can be used to operate the anchor 204 of. Close the anchor 204 by rotating the actuating knob 1712 in the first direction (eg, clockwise) with respect to the housing 1704 and / or pressing the mode selector button 1714 and moving the actuating knob 1712 proximally with respect to the housing 1704. Rotate the actuating knob 1712 in a second direction (eg, counterclockwise) with respect to the housing 1704 and / or press the mode selector button 1714 to move the actuating knob 1712 distally with respect to the housing 1704 to move the anchor 204. open.
With the anchor 206 of the prosthetic spacer device 200 positioned behind each natural valve leaflet, the clasp actuating mechanism 1708 of the handle 1700 is in a closed configuration (eg, FIGS. 20-22 show a closed clasp 206). Can be used to manipulate the clasp 206 of the prosthetic spacer device 200 between and an open configuration (eg, FIG. 23 shows a clasp 206 in an open configuration) to capture the spontaneous valve leaflets within each clasp 206. Moving the clasp actuator 1701 proximally with respect to the housing 1704 opens the clasp 206 of the prosthetic spacer device 200. The clasp actuator 1701 is moved distally with respect to the housing 1704 to close the clasp 206 of the prosthetic spacer device 200. Positioning the clasp actuator 1701 so that the holding member 1709 of the clasp actuator 1701 is located proximal to the holding element 1711 of the housing 1704 holds the clasp actuator 1701 in the most proximal position. Hold the clasp 206 of the prosthesis spacer device 200 in an open configuration. Lifting the clasp actuator 1701 over the holding element 1711 of the housing 1704 and moving the clasp actuator 1701 from its most proximal position allows the clasp actuator 1701 to move freely with respect to the housing, the prosthesis spacer device 200. Allows the clasp 206 to open and close. Both clasps 206 of the prosthetic spacer device 200 can be operated simultaneously when the clasp actuator 1701 is coupled together by pins 1713 (FIG. 72). Each clasp 206 of the prosthetic spacer device 200 can be operated independently when pin 1713 is removed from the clasp actuator 1701.
After the natural valve leaflets are trapped within the respective clasps 206 of the prosthetic spacer device 200, the anchor actuating mechanism 1706 of the handle 1700 mounts the anchor 204 of the prosthetic spacer device 200 in the valve leaflet capture configuration (eg, FIGS. 23-24). Can be used to operate from to closed configurations (eg, Figure 25). This is achieved by rotating the actuation knob 1712 in the first direction (eg, clockwise) with respect to the housing 1704 and / or pressing the mode selector button 1714 to move the actuation knob 1712 proximally with respect to the housing 1704. obtain. It then pulls the natural valve leaflet inward towards the spacer member 202 of the prosthetic spacer device 200, as shown in FIG.
The user can reopen the anchor 204 and / or the clasp 206 to reposition and / or remove the prosthetic spacer device 200 by manipulating the anchor actuating mechanism 1706 and / or the clasp actuating mechanism 1708.
After the spacer device 200 has been implanted in the desired arrangement, the user can release the delivery device from the prosthetic spacer device 200. One aspect of the release procedure is to release the clasp control member 524 from the clasp 206. This can be achieved by opening the locking member 1705 of handle 1700. The user inserts a scalpel into slot 1725 (FIG. 62) of the clasp actuator 1701 and makes contact with the clasp control member 524 to free the second end of the clasp control member 524 from each clasp actuator 1701. Can be disconnected. The user can then pull the first end portion of the clasp control member 524 until at least the second end portion exits the opening 234 of the clasp 206 of the prosthetic spacer device 200.
A second aspect of the solution procedure is to release the distal end portion 512b of the actuating shaft 512 from the distal collar 208 of the prosthetic spacer device 200. This can be achieved by moving the actuating knob 1712 to the most proximal position with respect to the housing 1704. This aligns the release pin 1760 axially with the window 1782 of the housing 1704, thereby ensuring that the anchor 204 of the prosthetic spacer device 200 is in a fully closed configuration. The user can separate from the ferrule 1766 by grasping the release pin 1760 and pulling it out through the window 1782 of the housing 1704. With the release pin 1760 removed, the actuation shaft 512 and thus the release knob 1756 can rotate with respect to the housing and move proximally with respect to the housing 1704, drive shaft 1758, and actuation knob 1712. Thus, the user can remove the actuating shaft 512 from the distal collar 208 of the prosthesis spacer device 200 by rotating the release knob 1756 of the handle 1700 in a second direction (eg, counterclockwise) with respect to the housing 1704. ..
A third aspect of the solution procedure is to release the outer shaft 520 from the proximal collar 210 of the prosthetic spacer device 200. This moves the release knob 1756 of the handle 1700 proximally until the distal end portion 512b of the actuating shaft 512 is located proximal to the coupler 514 of the delivery device, then the housing 1704 of the handle 1700 (and thus the outside). This can be achieved by moving the shaft 520) proximally with respect to the prosthesis spacer device 200.
With the delivery device released from the prosthetic spacer device 200, the catheters 504, 506, 508 of the delivery device 504 can be removed from the patient.
The features described herein with respect to an example may be combined with other features described in one or more of the other examples, unless otherwise noted. For example, a feature of the prosthetic spacer device 100 can be combined with the prosthetic spacer device 200 and vice versa. As another example, one or more of the features of the delivery device handle (eg, handles 522, 700, 1500, 1600, and / or 1700) may be with one or more of the features of another handle. Can be combined.
In light of the many possible embodiments to which the principles of the present disclosure can be applied, it is understood that the illustrated embodiments are only preferred examples and should not be construed as limiting the scope of the claims. Will. Rather, the claims are defined by the following claims and their equivalents.
100 Prosthodontic spacer device 102 Spacer member 104 Paddle or anchor 106 Clasp 108 First collar 110 Second collar 112 First end 114 First end 116 Second end 118 Second end 120 First Part 122 Second part 124 Joint part 126 Mounting part 128 Arm part 129 Plate 130 Opening 132 Side beam 134 Slot 136 Fixed end part 138 Free end part 140 Barb 142 Opening 144 Hemostasis sealing member 146 Flap 200 Prosthetic spacer Device 202 Spacer member 204 Anchor 206 Multiple clasps 208 1st or distal collar 210 2nd or proximal collar 212 Anchor extension member 214 1st or fixed end part 216 2nd or free end part 218 Joint part 220 1st part 222 2nd part 224 Cover 226 Bore 228 Central opening 230 Protrusion 232 Guide opening 234 Opening 236 Barb 300 Prosthesis Spacer Device 302 Ankle Spacer Member 304 Anchor 306 Sleeve 308 Prosthesis 400 Prosthodontic Spacer Device 402 Ankle Spacer Member 404 Anchor 406 Barb or Overhang 408 Stopper 500 Delivery Assembly 501 Lumen 502 Delivery Device 504 First Catheter 505 Flushing Tube 506 Second Catheter 507 Valve 508 Third Catheter 510 Catheter Stabilizer 512 Activating Shaft 512a Proximal End Part 512b Distal end 514 Coupler 516 First sheath or shaft 518 Second sheath or shaft 518a Distal end 518a Distal maneuverable section 518b Section 517, 519 Handle 520 Outer shaft 520a Proximal end 520b Distal end Part 520c Intermediate part 522 Handle 524 Clasp control member 526 Actuating knob 528 Flexible arm 530 Stabilizer member 532 Opening 533 Port 534 Small hole 536 Opening 538 Actuating shaft lumen 540 Control member lumen 542 Coil part 542a First coil 542b 2nd coil 542c 3rd coil 544 Coupling layer 546 Housing 548 Actuating locking mechanism 550 Clasp control mechanism 552 Flushing mechanism 554 Main body 556 Nose 558 Fastener 560 Pin 562 Acting shaft lumen 564 Control member lumen 566 Flushing lumen 568 Actuating tube 570 Control member tube 572, 574 Flange 576 Sealing member 578 Fastener 580 Actuating shaft lumen 582 Control member lumen 584 Lock (eg Tuohy-Borst Adapter) 586 Coupler (eg Mesluar Coupler) 588 Knob 590 Actuator Member 592 Locking Member 594 First Side 596 Second Side 598 Connection Pin 600 Natural Mitral Valve 602 Heart 604 Atrial septum 606 Left atrium 608 Spontaneous valve leaflet 610 Left ventricle 612 Joint line 700 Handle 702 Housing 704 Operation control mechanism 706 Main body 708 Operation lumen 710 Control member lumen 712 Flange part 714 Circumferential groove 716 Guide pin 718 Knob 720 Mounting pin 722 Drive screw 724 Collet 726 Second knob 728 Distal end part 730 Proximal end part 732 Side opening 734 Male screw 736 Slot 738 Lumbar 740 Distal end part 742 First distal part 744 Second proximal part 746 Proximal end part 800 Coupler 802 Proximal collar 804 Axial extension lumen 806 Radial extension opening 808 Proximal extension tab or Finger 810 Free end 812 Radial extension protrusion 900 Distal collar 902 Acting shaft 904 Opening member (eg wire) 906 Central bore 908 Tab or tongue 910 Side 912 Opening 1000 Coupler 1002 Proximal collar 1004 Distal collar 1006 Actuating shaft 1008 Connection part 1010 Pin 1012 Fixing member 1014 Axial extension lumen 1015 Recessed outward surface 1016 Opening 1020 Radial expandable part 1022 Distal end part 1100 Clasp control member 1102 Sleeve 1104 Connecting member 1106 Release member 1108 Sleeve 1200 Guide rail 1202 First side 1204 Second side 1300 Shaft 1302 Acting shaft lumen 1304, 1304a, 1304b, 1304c, 1304d Control member lumen 1306 First part 1308 Second part 1310 Third part 1400 Delivery assembly 1402 Prosthesis spacer device 1404 Delivery device 1406 Spacer member 1408 Anchor 1410 Clasp 1412 Proximal collar 1414 sleeve or cylinder 1416 piston 1418 distal end 1420 distal end 1422 proximal end 1424 opening 1426 outer shaft 1428 actuating shaft 1430 clasp control member 1432 tether 1434 actuating shaft lumen 1436 control member lumen 1438 Tether cavity 1440 Male screw 1500 Handle 1502 Connection member 1504 Flushing mechanism 1506 Housing 1508 Anchor actuation mechanism 1510 Clasp actuation mechanism 1512 Actuation knob 1514 Proximal end part 1516 Proximal end part 1518 Proximal end part 1518 Slit or groove 1520 Nose part 1522 Body part 1524 Fastening Tools (eg bolts) 1526 Acting shaft lumen 1528 Control member lumen 1530 Acting tube 1534 Slot 1536 Bore 1538 Drive screw 1540 Release knob 1542 Release pin 1544 Bushing 1546 Mode selector button 1548 Bias element (eg spring) 1550 Flange 1554 Recess or "flat" 1556 First opening 1558 Second opening 1560 tabs 1562 grooves 1564, 1566 locking elements 1568 lumen 1570 distal part 1572 proximal parts 1574 openings 1576 first part 1578 second parts 1580 ears 1582 slots 1584 tabs 1586 rails 1588 notches 1600 handles 1602 connecting members 1604 Housing 1606 Anchor actuation mechanism 1608 Clasp actuation mechanism 1610 Actuation knob 1612 Nose part 1614 Body part 1616 Support part 1618 Slot 1620 Bore 1622 Release pin 1624 Bushing 1626 Mode selector button 1628 Biasing member (for example, spring) 1630 Actuating tube 1632 Drive screw 1634 Release knob 1636 Distal part 1638 Clasp tube 1640 Actuator 1642 Locking member 1644 Pin 1648 Holding Elements 1648a, 1648b, 1648c, 1648d Holding elements 1684a, 1684b, 1684c, 1648d Holding elements 1700 Handle 1701 Clasp actuator 1701a First clasp actuator 1701b Second clasp actuator 1702 Connecting member 1703 Clasp tube 1704 Housing 1705 Locking member 1706 Anchor Actuator mechanism 1707 Support 1708 Clasp actuating mechanism 1709 Retaining member 1710 Flushing mechanism 1711 Retaining element 1712 Actuating knob 1713 Pin 1714 Mode selector button 1715 Stopper 1716 Body part 1716a First part 1716b Second part 1717 Opening 1718 Support part 1718a First part 1718b Second 1719 Rise 1720 Support 1721 Notch 1722 Coupling 1723 Opening 1724 Stabilizer Member 1725 Slot 1726 Shaft Guide Member 1727 Open 1728 Shaft 1729 Recess 1730 Flange 1731 Protrusion 1732 Cavity 1732a, 1732b, 1732c Segment 1733 Axis 1734 Protrusions or ridges 1735 Axis 1736 Fasteners 1738 Partitions 1739 Tabs 1741 Supports 1742 Openings 1743 Ports 1744 Sleeves 1746 Clasp Control Cavities 1748 Activating Shaft Cavities 1750 Flushing Cavities 1752 First Part 1754 Second Part 1756 Release Knob 1758 Drive Shaft 1758a Proximal End Part 1758b Distal End Part 1760 Release Pin 1762 Distal Acting Sleeve 1764 Proximal Acting Sleeve 1766 Ferrule 1768 Bushing 1770 Proximal Opening 1772 Opening 1774 C-Clip 1776 Threaded Part 1778 Tab or Protrusion 1780 Chamber 1782 Window 1784 First recess 1786 Jaw 1788 Steps 1790 Second recess 1792 Jaw 1794 Steps 1796 Slot 1798 Surface 1800 Clasp Positioning Tool 1802 Body 1804 Protrusion 1806 First Opening 1808 Second Opening 1810 Lip or Step 1812 Flange
80 sheets
Sheet 1 Sheet 2 Sheet 3 Sheet 4 Sheet 5 Sheet 6 Sheet 7 Sheet 8 Sheet 9 Sheet 10 Sheet 11 Sheet 12 Sheet 13 Sheet 14 Sheet 15 Sheet 16 Sheet 17 Sheet 18 Sheet 19 Sheet 20 Sheet 21 Sheet 22 Sheet 23 Sheet 24 Sheet 25 Sheet 26 Sheet 27 Sheet 28 Sheet 29 Sheet 30 Sheet 31 Sheet 32 Sheet 33 Sheet 34 Sheet 35 Sheet 36 Sheet 37 Sheet 38 Sheet 39 Sheet 40 Sheet 41 Sheet 42 Sheet 43 Sheet 44 Sheet 45 Sheet 46 Sheet 47 Sheet 48 Sheet 49 Sheet 50 Sheet 51 Sheet 52 Sheet 53 Sheet 54 Sheet 55 Sheet 56 Sheet 57 Sheet 58 Sheet 59 Sheet 60 Sheet 61 Sheet 62 Sheet 63 Sheet 64 Sheet 65 Sheet 66 Sheet 67 Sheet 68 Sheet 69 Sheet 70 Sheet 71 Sheet 72 Sheet 73 Sheet 74 Sheet 75 Sheet 76 Sheet 77 Sheet 78 Sheet 79 Sheet 80
Every citation, both ways
| Document | Relation | Office | Category | Cited during | Relevant claims |
|---|---|---|---|---|---|
| JP2023527936A | Cited by | Japan | – | Search report | – |
| US2004220593A1 | Cites | United States of America | – | Search report | – |
| JP2014530666A | Cites | Japan | – | Search report | – |
| WO2016183485A1 | Cites | World Intellectual Property Organization (WIPO) | X | Search report | 1-2,8-15 |
| US2017100250A1 | Cites | United States of America | – | Search report | – |
398 members in 28 offices
Priority claims9
| Document | Office | Kind | Date |
|---|---|---|---|
| 62504389 | United States of America | – | |
| 201762504389 | United States of America | P | |
| 62571552 | United States of America | – | |
| 201762571552 | United States of America | P | |
| 62659253 | United States of America | – | |
| 201862659253 | United States of America | P | |
| 15973892 | United States of America | – | |
| 201815973892 | United States of America | A | |
| 2018031959 | United States of America | W |
Members398
| Document | Office | Kind | |
|---|---|---|---|
| US2018296326A1 | United States of America | A1 | |
| US2018296327A1 | United States of America | A1 | |
| US2018296328A1 | United States of America | A1 | |
| US2018296329A1 | United States of America | A1 | |
| US2018296330A1 | United States of America | A1 | |
| US2018296331A1 | United States of America | A1 | |
| US2018296332A1 | United States of America | A1 | |
| US2018296333A1 | United States of America | A1 | |
| US2018296334A1 | United States of America | A1 | |
| CA3052493A1 | Canada | A1 | |
| CA3052680A1 | Canada | A1 | |
| CA3240581A1 | Canada | A1 | |
| WO2018195015A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO2018195201A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO2018195215A2 | World Intellectual Property Organization (WIPO) | A2 | |
| CA3061231A1 | Canada | A1 | |
| US2018325661A1 | United States of America | A1 | |
| WO2018209021A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO2018195215A3 | World Intellectual Property Organization (WIPO) | A3 | |
| US2019000613A1 | United States of America | A1 | |
| US2019008642A1 | United States of America | A1 | |
| US2019008643A1 | United States of America | A1 | |
| US2019015199A1 | United States of America | A1 | |
| US2019015200A1 | United States of America | A1 | |
| US2019015207A1 | United States of America | A1 | |
| US2019015208A1 | United States of America | A1 | |
| US2019021851A1 | United States of America | A1 | |
| US2019021852A1 | United States of America | A1 | |
| US2019029810A1 | United States of America | A1 | |
| US2019029813A1 | United States of America | A1 | |
| US2019060058A1 | United States of America | A1 | |
| US2019060059A1 | United States of America | A1 | |
| US2019060073A1 | United States of America | A1 | |
| US2019060074A1 | United States of America | A1 | |
| US2019060075A1 | United States of America | A1 | |
| US2019069991A1 | United States of America | A1 | |
| US2019069992A1 | United States of America | A1 | |
| US2019069993A1 | United States of America | A1 | |
| CA3073825A1 | Canada | A1 | |
| WO2019051180A2 | World Intellectual Property Organization (WIPO) | A2 | |
| WO2019051180A3 | World Intellectual Property Organization (WIPO) | A3 | |
| US2019142579A1 | United States of America | A1 | |
| US2019142580A1 | United States of America | A1 | |
| CN109963529A | China | A | |
| SG11201907076YA | Singapore | A | |
| SG11201907077UA | Singapore | A | |
| EP3531979A1 | European Patent Office (EPO) | A1 | |
| EP3531979A4 | European Patent Office (EPO) | A4 | |
| AU2018255337A1 | Australia | A1 | |
| MX2019010331A | Mexico | A | |
| MX2019010326A | Mexico | A | |
| CA3097354A1 | Canada | A1 | |
| US2019321166A1 | United States of America | A1 | |
| WO2019204559A1 | World Intellectual Property Organization (WIPO) | A1 | |
| EP3558168A1 | European Patent Office (EPO) | A1 | |
| EP3558169A2 | European Patent Office (EPO) | A2 | |
| AU2018256385A1 | Australia | A1 | |
| CN110418623A | China | A | |
| KR20190132358A | Republic of Korea | A | |
| KR20190132362A | Republic of Korea | A | |
| IL269654A | Israel | A | |
| IL269654D0 | Israel | D0 | |
| IL269799A | Israel | A | |
| IL269799D0 | Israel | D0 | |
| SG11201909647XA | Singapore | A | |
| CN110536656A | China | A | |
| CR20190348A | Costa Rica | A | |
| EP3558168A4 | European Patent Office (EPO) | A4 | |
| US10507108B2 | United States of America | B2 | |
| CR20190368A | Costa Rica | A | |
| US10524913B2 | United States of America | B2 | |
| CO2019012584A2 | Colombia | A2 | |
| MX2019012661A | Mexico | A | |
| US2020030085A1 | United States of America | A1 | |
| US2020030098A1 | United States of America | A1 | |
| CN210077948U | China | U | |
| CO2019012710A2 | Colombia | A2 | |
| EP3558169A4 | European Patent Office (EPO) | A4 | |
| MX2020001931A | Mexico | A | |
| BR112019021183A2 | Brazil | A2 | |
| SG11202001929YA | Singapore | A | |
| US2020138567A1 | United States of America | A1 | |
| US10646342B1 | United States of America | B1 | |
| BR112019021267A2 | Brazil | A2 | |
| CN111200995A | China | A | |
| US10667912B2 | United States of America | B2 | |
| JP2020516364A | Japan | A | |
| JP2020516369A | Japan | A | |
| JP2020519314AThis record | Japan | A | |
| CN110536656A8 | China | A8 | |
| EP3678596A2 | European Patent Office (EPO) | A2 | |
| EP3682854A1 | European Patent Office (EPO) | A1 | |
| EP3685802A1 | European Patent Office (EPO) | A1 | |
| EP3689299A1 | European Patent Office (EPO) | A1 | |
| US2020246136A1 | United States of America | A1 | |
| EP3678596A4 | European Patent Office (EPO) | A4 | |
| US2020315786A1 | United States of America | A1 | |
| US10820998B2 | United States of America | B2 | |
| MX2020010263A | Mexico | A | |
| JP2020533090A | Japan | A |
9 legal events, as the office reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | |
|---|---|---|
| Receipt of annual feesJAPANESE INTERMEDIATE CODE: R250R250 | R250 | |
| First payment of annual fees (during grant procedure)JAPANESE INTERMEDIATE CODE: A61A61 | A61 | |
| Certificate of patent or registration of utility modelJAPANESE INTERMEDIATE CODE: R150R150 | R150 | |
| Written decision to grant a patent or to grant a registration (utility model)JAPANESE INTERMEDIATE CODE: A01A01 | A01 | |
| Decision of grant or rejection writtenTRDD | TRDD | |
| Request for written amendment filedJAPANESE INTERMEDIATE CODE: A523A521 | A521 | |
| Notification of reasons for refusalJAPANESE INTERMEDIATE CODE: A131A131 | A131 | |
| Report on retrievalJAPANESE INTERMEDIATE CODE: A971007A977 | A977 | |
| Written request for application examinationJAPANESE INTERMEDIATE CODE: A621A621 | A621 |
Numbers
- Publication
- 2020519314
- Application
- 2019518503
Titles2
- Japanese
- 僧帽弁スペーサーデバイス
- English
- Mitral valve spacer device
Classification
- CPC, 12
- A61F2/246
- A61F2/2463
- A61F2/2466
- A61B17/1227
- A61B17/1285
- A61F2220/0016
- A61F2220/0008
- A61F2220/0075
- A61B2017/00783
- A61F2210/0014
- A61B2017/00243
- A61F2/9517
- IPC, 1
- A61F2 24
Designated states5
- Regional, 4
- Zimbabwe
- Turkmenistan
- Türkiye
- Togo
- National, 1
- Trinidad and Tobago