Composition and method to form self-decontaminating surface

Embodiments generally relate to chemical compositions that form self-contaminating decontaminated surfaces and methods of using the compositions. In certain embodiments, the chemical composition comprises a photocatalyst. In certain embodiments, the photocatalyst comprises a titanium oxide moiety. In certain embodiments, the chemical composition comprises an organosilane.

In the publications with the following names, "Evaluation of Two Organosilane Products for Sustained Antimicrobial Activity on High-Touch Surfaces in Patient Rooms", American Journal of Infection Control, Vol. 42 (2014), pp. 326-8, among others, "Our knowledge" As far as the authors have done, the first disclosure is to apply organosilane compounds to the high-frequency contact surfaces of hospital rooms as a strategy to reduce the level of microbial contamination of the environmental surface between daily cleanings. This is a controlled study that was conducted. " Previous work, p. 327. The authors found that the two organosilanes were not effective for any type of sustained antibacterial efficacy. "In conclusion, our study was unable to demonstrate sustained antibacterial activity for the organosilane products tested when applied to high frequency contact surfaces." Previous work, p. 328.

<p><nplcit num="1"><text>American Journal of Infection Control Vol. 42 (2014) pp. 326-8</text></nplcit></p>

<p> The present invention will be better understood by reading the following detailed description, in which similar reference numerals are interpreted in conjunction with the drawings used to indicate similar elements. The present invention provides, for example, the following items. (Item 1) Structure:<chemistry num="15"><img file="JP2019007011A_D0001.tif" /></chemistry>Amino polyol having, in the formula, R4 is -H and -CH₂-CH₂Amino polyols selected from the group consisting of -OH, and structure:<chemistry num="16"><img file="JP2019007011A_D0002.tif" /></chemistry>Organosilane with, in the formula, R1 is -H, -CH₃, And -CH₂-CH₃Selected from the group consisting of R2, -OH, -O-CH₃, O-CH₂-CH₃, An alkyl, an alkyl having a chlorine moiety, an alkyl having an amino moiety, and an alkyl having a quaternary ammonium group, selected from the group, formed by reacting with an organosilane. (Item 2) Structure:<chemistry num="17"><img file="JP2019007011A_D0003.tif" /></chemistry>The polymer material according to item 1, which comprises a linear polymer having. (Item 3) Structure:<chemistry num="18"><img file="JP2019007011A_D0004.tif" /></chemistry>The polymer material according to item 1, which comprises a branched polymer having. (Item 4) Structure:<chemistry num="19"><img file="JP2019007011A_D0005.tif" /></chemistry>The polymer material of item 1, comprising a crosslinked polymer having. (Item 5) Structure:<chemistry num="20"><img file="JP2019007011A_D0006.tif" /></chemistry>The polymer material of item 1, comprising a crosslinked polymer having. (Item 6) Structure:<chemistry num="21"><img file="JP2019007011A_D0007.tif" /></chemistry>The polymer material of item 1, comprising a crosslinked polymer having. (Item 7) The polymer material according to item 1, further comprising a mixture of a peroxotitanate solution and a peroxo-modified anatase sol. (Item 8) The polymeric material according to item 7, further comprising titanium dioxide. (Item 9) The polymer material according to item 1, wherein the organosilane contains silanetriol. (Item 10) Structure:<chemistry num="22"><img file="JP2019007011A_D0008.tif" /></chemistry>Further comprises silsesquioxane having, where R2 is -OH, -O-CH₃, O-CH₂-CH₃The polymer material according to item 1, which is selected from the group consisting of alkyl, alkyl having a chlorine moiety, alkyl having an amino moiety, and alkyl having a quaternary ammonium group. (Item 11) Substantially from the step of placing the aqueous mixture of the peroxotitanic acid solution and the peroxo-modified anatase sol (collectively, the titanium oxide moiety) on the object, the aqueous mixture in which the titanium oxide moiety is arranged. The step of evaporating all the water to leave a layer containing a mixture of at least 90% by weight of the peroxotitanic acid solution and the peroxo-modified anatase sol, the step of placing an aqueous mixture of organosilanes on the object, and said. A composition formed by a method comprising evaporating substantially all of the water from the aqueous mixture in which the organosilane is located, leaving a layer containing at least 90% by weight of the organosilane. (Item 12) The method of item 11, wherein the object is selected from the group consisting of walls, doors, tables, trays, bedding, quilts, or furniture cushions. (Item 13) The layer containing a mixture of at least 90% by weight of the peroxotitanate solution and the peroxo-modified anatase sol is first formed on the object, and the layer containing at least 90% by weight of the organosilane is at least 90. The method of item 11, which is formed on the layer comprising a mixture of a weight percent peroxotitanate solution and a peroxo modified anatase sol. (Item 14) The layer containing at least 90 weight percent of the organosilane is initially formed on the object and comprises at least 90 weight percent of the peroxotitanic acid solution and the mixture of peroxo modified anatase sol. The method of item 11, wherein the layer is formed on top of the layer containing at least 90 weight percent of the organosilane. (Item 15) A step of simultaneously placing an aqueous mixture of a peroxotitanate solution and a peroxo-modified anatase sol and an aqueous mixture of organosilanes on an object. Virtually all water is evaporated from the object to obtain a mixture containing at least about 45% by weight of the organosilane and at least about 45% by weight of the mixture of peroxotitanate solution and peroxo modified anatase sol. A composition formed by a method comprising leaving steps. (Item 16) Substantially from the step of placing the aqueous mixture of the peroxotitanic acid solution and the peroxo-modified anatase sol (collectively, the titanium oxide moiety) on the object, the aqueous mixture in which the titanium oxide moiety is arranged. The step of evaporating all the water to leave a layer containing a mixture of at least 90% by weight of the peroxotitanic acid solution and the peroxo modified anatase sol, the step of placing an aqueous mixture of organosilanes on the object, and said. A method comprising evaporating substantially all of the water from the aqueous mixture in which the organosilane is located, leaving a layer containing at least 90% by weight of the organosilane. (Item 17) The method of item 16, wherein the object is selected from the group consisting of walls, doors, tables, trays, bedding, comforters, or furniture cushions. (Item 18) The layer containing a mixture of at least 90% by weight of the peroxotitanate solution and the peroxo-modified anatase sol is first formed on the object, and the layer containing at least 90% by weight of the organosilane is at least 90. The method of item 16, which is formed on the layer comprising a mixture of a weight percent peroxotitanate solution and a peroxo modified anatase sol. (Item 19) The layer containing at least 90 weight percent of the organosilane is initially formed on the object and contains at least 90 weight percent of the mixture of peroxotitanic acid solution and peroxo modified anatase sol. The method of item 16, wherein the layer is formed on top of the layer containing at least 90 weight percent of the organosilane. (Item 20) A step of simultaneously arranging an aqueous mixture of a peroxotitanate solution and a peroxo-modified anatase sol and an aqueous mixture of organosilanes on the object. Virtually all water is evaporated from the object to obtain a mixture containing at least about 45% by weight of the organosilane and at least about 45% by weight of the mixture of peroxotitanate solution and peroxo modified anatase sol. The method of item 16, including steps to leave. (Item 21) A method comprising forming an aqueous mixture of choline present in 7.5 weight percent, dipping and coating a stainless steel test coupon in an aqueous choline mixture, and evaporating water from the coated test coupon. .. (Item 22) Steps to form an aqueous mixture of choline present in 7.5 weight percent and aminopropyltriethoxysilane present in 5 weight percent, stainless steel test coupon, use aqueous choline and aminopropyltriethoxysilane mixture 21. The method of item 21, further comprising a step of dipping and coating, and a step of evaporating water from the coated test coupon.</p>

<figref num="1">Figure 1 graphically illustrates the number of in-hospital C-difficile infections in the Glendale Memorial Hospital ICU from January 2012 to February 2014.</figref>

<figref num="2">Figure 2 graphically shows the number of in-hospital C-difficile infections at Glendale Memorial Hospital (excluding ICU) from January 2012 to February 2014.</figref>

<figref num="3">FIG. 3 shows the applicants' sterilization station 300.</figref>

The present invention will be described in a preferred embodiment of the following description with reference to figures in which similar references represent the same or similar elements. When referring to "one embodiment," "embodiment," or similar language throughout the specification, a particular feature, structure, or feature described in connection with an embodiment is at least one of the invention. It means that it is included in the embodiment. Thus, the appearance of the words "in one embodiment", "in an embodiment", and similar languages throughout the specification refers to all, but not necessarily, the same embodiments.

The features, structures, or features of the invention described may be combined in any suitable manner in one or more embodiments. In the following description, a number of specific details are listed for a complete understanding of the embodiments of the present invention. However, one of ordinary skill in the art will appreciate that the invention can be practiced in the absence of one or more of the specific details, or with other methods, components, materials, and the like. In other cases, well-known structures, materials, or operations are not shown or described in detail in order to avoid obscuring aspects of the invention.

In certain embodiments of the Applicants' compositions and methods, a coating is formed on the surface of the object, the coating containing multiple titanium-oxygen bonds, and a peroxotitanate solution and peroxomodification. It is formed by placing a mixture with anatase sol (collectively, the "titanium-oxygen moiety") on the surface.

In certain embodiments, the applicant's titanium-oxygen moiety comprises a mixture of peroxotitanate solution and peroxo-modified anatase sol, loaded up to approximately 1 weight percent in total. In certain embodiments, the applicant's titanium-oxygen moiety comprises about 0.5 weight percent peroxotitanate solution in combination with about 0.5 weight percent peroxo-modified anatase sol.

Methods for preparing both peroxotitanate solutions and peroxo-modified anatase sol are disclosed in the Journal of Sol-Gel Science and Technology, September 2001, Vol. 22, No. 1-2, pp. 33-40. This publication discloses, among other things, the reaction scheme 1 presented directly below, which summarizes the synthetic procedures for both peroxotitanate solution and peroxo-modified anatase sol.<chemistry num="1"><img file="JP2019007011A_D0009.tif" /></chemistry>

In one embodiment of the Applicants' composition and method, the Applicants' coating formulation comprises a mixture of a peroxotitanate solution and a peroxo-modified anatase sol. In another embodiment of the applicants' compositions and methods, the coating is formed on the surface of an object, the coating comprising a plurality of titanium-oxygen bonds in combination with a plurality of silicon-oxygen bonds. , A mixture of peroxotitanic acid solution and peroxo modified anatase sol is formed by arranging it on the surface in combination with organosilane.

In certain embodiments, a coating containing multiple titanium-oxygen bonds in combination with multiple silicon-oxygen bonds first places the organosilane on the surface, then on the organosilane, a peroxotitanium solution and peroxo. It is formed by placing a mixture with a modified anatase sol.

In certain embodiments, a coating comprising multiple titanium-oxygen bonds in combination with multiple silicon-oxygen bonds first places a mixture of peroxotitanate solution and peroxo-modified anatase sol on the surface, and then places it on the surface. It is formed by placing organosilanes on a mixture of peroxotitanate solution and peroxo modified anatase sol. In certain embodiments, a coating containing multiple titanium-oxygen bonds in combination with multiple silicon-oxygen bonds simultaneously places a mixture of peroxotitanic acid solution and peroxo-modified anatase sol and organosilanes on the surface. Is formed by

In certain embodiments, the applicants' organosilanes are organosilanes.<u style="single">1</u>including.<chemistry num="2"><img file="JP2019007011A_D0010.tif" /></chemistry>

In certain embodiments, both R1 and R2 are alkyl. In other embodiments, R1 is alkyl and R2 is alkyl with an amino moiety. In yet another embodiment, R1 is alkyl and R2 contains a quaternary ammonium group. In yet another embodiment, R1 is alkyl and R2 contains a chlorine moiety. In yet another embodiment, R1 is alkyl and R2 is -O-CH.₃And -O-CH₂-CH₃Selected from the group consisting of.

In certain embodiments, the applicants' organosilanes are trihydroxysilanes.<u style="single">2</u>including. In certain embodiments, R2 is alkyl. In other embodiments, R2 is an alkyl having an amino moiety. In yet another embodiment, R2 comprises a quaternary ammonium group. In yet another embodiment, it comprises a chlorine moiety. In yet another embodiment, R2 is -OH.<chemistry num="3"><img file="JP2019007011A_D0011.tif" /></chemistry>

In certain embodiments, the applicants' organosilanes are silanetriols in which R2 is alkyl.<u style="single">2</u>including. In other embodiments, the Applicants' organosilanes are silanetriols in which R2 is an alkyl having an amino moiety.<u style="single">2</u>including. In yet another embodiment, the Applicants' organosilanes are silanetriols in which R2 is an alkyl having a quaternary ammonium group.<u style="single">2</u>including.

Cyril esters, as understood by those skilled in the art and as shown in formula (1).<u style="single">1</u>Cyril esters such as silanetriol<u style="single">2</u>It can be easily hydrolyzed to the corresponding silanetriols such as. Cyril ester even when exposed to atmospheric moisture<u style="single">1</u>The silane triol<u style="single">2</u>Sufficient to hydrolyze.<chemistry num="4"><img file="JP2019007011A_D0012.tif" /></chemistry>

Silsesquioxane is an organosilicon compound<u style="single">3</u>Is. In certain embodiments, R2 is alkyl. In other embodiments, R2 is an alkyl having an amino moiety. In yet another embodiment, R2 is an alkyl having a chlorine moiety. In yet another embodiment, R2 is an alkyl having a quaternary ammonium group.<chemistry num="5"><img file="JP2019007011A_D0013.tif" /></chemistry>

In certain embodiments, the applicants' silanetriols<u style="single">2</u>Was applied to any of the hard surfaces, i.e. walls, doors, tables, etc., or soft surfaces, i.e. bedding, comforters, furniture cushions, etc., and then placed on the hard / soft surfaces. The coated coating is multiple silsesquioxane<u style="single">3</u>Includes structure. In certain embodiments, the applicants' silanetriols<u style="single">2</u>In combination with titanium dioxide and applied to either hard surfaces such as walls, doors and tables, or soft surfaces such as bedding, quilts, and furniture cushions, and then to hard / soft surfaces. The arranged, resulting coating has multiple silsesquioxane structures.<u style="single">3</u>Includes in combination with the applicant's titanium-oxygen moiety.

The following examples are presented to further demonstrate to those skilled in the art how to use the present invention. However, these examples do not limit the scope of the present invention.

<p> (Example I) The study was conducted at the Glendale Memorial Hospital and Health Center, Glendale, CA (Glendale Memorial Hospital Study). The center has a 24-bed intensive care unit (ICU). The study was conducted between May 10 and September 30, 2013.</p><p> The Glendale Memorial Hospital Study was designed to evaluate the antibacterial properties of the applicant's coating compositions and methods, and the method used utilized the applicant's initial coating of organosilanes, followed by titanium dioxide. It was oversprayed. The entire ICU is subjected to a two-step spray regimen with hard surfaces (beds, tray tables, bed railings, walls, etc.) and soft surfaces (hangers, cloth and vinyl-covered chairs, woven fabrics, non-woven fabrics, and All objects in each room, including leather products) were processed. The purpose of the Glendale Memorial Hospital Study was to evaluate the antibacterial efficacy of the applicants' coating compositions in practical applications in a health care environment.</p><p> Octadecylaminodimethyltrihydroxysilylpropylammonium chloride on each surface<u style="single">6</u>Was first electrostatically spray coated at room temperature using an aqueous composition formed by mixing 3.6 weight percent with water.<chemistry num="6"><img file="JP2019007011A_D0014.tif" /></chemistry></p><p> Octadecylaminodimethyltrihydroxysilylpropylammonium chloride<u style="single">6</u>After about 15 minutes of electrostatic spray coating with an aqueous mixture of, most of the water evaporates and at least 90 weight percent (90 wt%) of octadecylaminodimethyltrihydroxysilylpropylammonium chloride<u style="single">6</u>The coating containing was left. Then, at room temperature, each surface was electrostatically spray coated using the applicant's titanium oxide moieties. After about 15 minutes, most of the water in the second spray deposits evaporated, leaving a coating containing at least 90 weight percent (90 wt%) of the applicant's titanium oxide moiety.</p><p>Aqueous octadecylaminodimethyltrihydroxysilylpropylammonium chloride on the treated surface<u style="single">6</u>It was maintained at room temperature during the spray deposition of the Titanium oxide portion of the applicants. None of the treated objects were subjected to any high temperature heat treatment to heat the treated surface to a temperature above approximately room temperature during or after the application's spray coating regimen.</p><p> Applicants used the Applicants' two-step spray coating protocol described above to evaporate water from the spray-deposited titanium oxide moiety and from the spray-deposited aqueous octadecylaminodimethyltrihydroxysilylpropylammonium chloride. After evaporating the water, the combined weight of the applicant's titanium oxide moiety placed on the treated surface and octadecylaminodimethyltrihydroxysilylpropylammonium chloride is 0.76 mg / in.²I found that it was measured.</p><p> Initial microbial sampling of various mediators was performed to assess surface bacterial levels in various hospitals prior to selecting study sites. After review, 95 sites were selected for study in the ICU. Each of the 95 specific points within the ICU was selected to repeat sampling at 1, 2, 4, 8, and 15 weeks after application of the Applicants' composition. These selected points included bed railings, bed controls, tray tables, and walls on the sink. Samples were also collected from two ICU nurse stations and a waiting room, including a counter, telephone, computer keyboard, chair armrests, and end table. All movable items were tagged and coded inconspicuously during the course of the study so that the same object could be sampled.</p><p> At each of these points, 1 week (6-8 days), 2 weeks (13-17 days), 4 weeks (29-32 days), 8 weeks before and after applying the Applicants' method. Culturing was carried out at (59 to 62 days) and 15 weeks (104 to 107 days). Some objects were removed and these were not available for culture at some of the subsequent time points.</p><p> 100 cm²Areas were sampled using sponge sticks containing Letheen broth (3M, St. Paul, MN) to neutralize any residual disinfectant. Immediately after collection, the samples were placed on ice packs and sent overnight to the University of Arizona. After receipt, broth was extracted from the sponge stick by manual agitation, and then 4 mL of the extracted broth was assayed using selective medium to isolate various bacteria. Samples were cultured for total bacteria, Clostridium difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococcus (VRE), and carbapenemase-resistant Enterobacteriaceae (CRE). The test methods for each organism are presented in Table 5.<tables num="5"><img file="JP2019007011A_D0015.tif" /></tables></p><p> 100 cm everywhere²Table 6 shows the average number of total bacteria detected per hit and the percentage reduction in the total number of bacteria after treatment.<tables num="6"><img file="JP2019007011A_D0016.tif" /></tables></p><p> As can be seen from the table, the bacterial count was always 99.9% lower after treatment for 4 weeks, 99% after 8 weeks and still almost 99% after 15 weeks.</p><p> Significantly, as shown in Table 7, 10,000 CFU / 100 cm²The number of sites containing supers decreased from 71.5% of the sites before treatment to zero in the next 8 weeks, and even after 15 weeks, only 11.1% of the sites exceeded this number.<tables num="7"><img file="JP2019007011A_D0017.tif" /></tables></p><p> A bootstrap analysis of variance (ANOVA) was performed at each stage between the baseline concentration for the sampled medium and the intervention concentration for the same medium to determine a statistically significant difference based on a rejection area of 5%. .. Based on the p-value (&lt;0.0005), there was a statistically significant difference between baseline and mediator concentrations throughout the 15 weeks of study.</p><p> Table 8 shows the percentage of samples in which antibiotic-resistant strains were isolated at various points sampled.<tables num="8"><img file="JP2019007011A_D0018.tif" /></tables></p><p> Antibiotic resistant strains were isolated from all study areas during baseline sampling except for C. difficile. VRE was the most commonly isolated organism.</p><p> Prior to treatment, antibiotic resistant strains were isolated from 25% of the sampled sites. After treatment, antibiotic bacteria were not isolated until 8 weeks when VRE was found in 1 of 64 samples (from the armrest of the chair) (1.5%).</p><p> The studies of the present invention demonstrate that the use of Applicants' methods reduced the number of bacteria on the vector by more than 99% over 8 weeks after a single treatment (Table 6).</p><p> Bacterial levels were reduced by 99.9% 4 weeks after treatment. The overall average level of bacteria never returned to the level observed before treatment. Bacterial counts increased between 8 and 15 weeks after treatment, but the average bacterial count on all treated surfaces was still less than 90% after 15 weeks. 10,000 CFU / 100 cm compared to 25.2% before processing²No higher values were seen over 4 weeks after treatment, and even after 15 weeks, only 11.1% of values exceeded this amount.</p><p> Antibiotic-resistant strains were not isolated until 8 weeks after treatment, and then isolated at levels lower than those seen before treatment (Table 8). Neither MRSA nor CRE was isolated even 15 weeks after treatment, only VRE was isolated 8 weeks later. C. difficile was not isolated at baseline or after treatment. However, C. difficile was isolated in the initial screening used to select sampling points.</p><p> In conclusion, the antibacterial effect obtained from the use of the applicants' compositions and methods lasted for 15 weeks to reduce the total number of bacteria and antibiotic resistant strains on both hard and soft surfaces in the ICU. I understood it. Hard surfaces included bare metal surfaces, painted metal surfaces, epoxy coated surfaces, unpainted wood surfaces, painted wood surfaces, and glass.</p><p> The 15-week antibacterial efficacy demonstrates that the applicants' composition forms an antifouling and antibacterial coating on the treated surface. Applicants' compositions, and the coatings obtained by forming them, can generate self-contaminating decontamination surfaces that are both antifouling and antibacterial, thereby providing health care and industrial. A cost-effective route is provided to minimize the transmission of disease through high-frequency contact surfaces in these applications.</p><p> Figure 1 graphically illustrates the number of in-hospital C-difficile infections in the Glendale Memorial Hospital ICU from January 2012 to February 2014. Figure 1 shows that during the period from May 2013 to November 2013, there was no in-hospital C-difficile infection caused by ICU except in September 2013. Therefore, Figure 1 shows that during the 6-month period from May 2013 to November 2013, there was only one in-hospital C-difficile infection in the ICU.</p><p> Figure 1 also shows 1 in-hospital C-difficile infection in the ICU during the 25 months from January 2012 to February 2014, except for the 6-month period from May 2013 to November 2013. Indicates that there was no other 6-month period in which only one occurred. All surfaces within the ICU were treated as described above during the first week of May 2013 as part of the Glendale Memorial Hospital Study.</p><p> Figure 2 graphically shows the number of in-hospital C-difficile infections at Glendale Memorial Hospital (excluding ICU) from January 2012 to February 2014. Figure 2 shows that there were between 1 and 8 cases of in-hospital C-difficile infection each month during the 25-month period in non-ICU in-hospital areas, except in April 2013. During the period from May 2013 to November 2013, Figure 2 shows that a total of 20 in-hospital C-difficile infections occurred outside the ICU at Glendale Memorial Hospital.</p><p> Figures 1 and 2 show that during the period from May 2013 to November 2013, the Glendale Memorial Hospital ICU had only one in-hospital C-difficile infection, with a total of 20 outside the ICU at the Glendale Memorial Hospital. Indicates that an example of in-hospital C-difficile infection has occurred.</p><p> Applicants can spray octadecylaminodimethyltrihydroxysilylpropylammonium chloride and their titanium oxide moiety onto the bandage before using the wound covering or by dip coating. I found that it can be placed. As will be appreciated by those skilled in the art, bandages are sterile pads or compression gauze applied to the wound to promote healing and / or prevent further damage. Bandages are designed to be in direct contact with the wound and are distinguished from the bandages most often used to hold the bandage in place. In certain embodiments, Applicants' wound bandages include: alginates and other fibrous gelled bandages, including ropes and sheets, composite bandages, adhesive edges. Foam bandages with and without adhesive edges, gauze with and without adhesive edges, hydrophilic colloids, special absorbent bandages with and without adhesive edges, transparent films, collagen bandage sheets and ropes, with adhesive edges And not equipped with hydrogel sheets, cotton packing strips, roll gauze, paper tape, silk tape, compression bandages (elastic, knitted / woven), self-adhesive bandages (elastic, unwoven / unwoven).</p><p> (Example II) In this Example II, the components of the applicant's composition are placed on the target surface in the reverse order. More specifically, in this Example II, Applicants first place their titanium oxide moiety on the target surface, evaporate the aqueous moiety of the first spray deposit, and then octadecylaminodimethyltrihydroxysilyl. Propylammonium chloride<u style="single">6</u>Is placed on the previously placed titanium oxide portion.</p><p> The test coupons for Example II were prepared using the procedures listed directly below. In certain embodiments, the processed coupons were stored for at least 4 weeks and then inoculated with various organisms.</p><p> Table 9 lists efficacy data for processed coupons after inoculation with E. coli. Table 10 lists efficacy data for processed coupons after inoculation with MS-2. Table 11 lists efficacy data for processed coupons after inoculation with MRSA.</p><p> In summary, Tables 9, 10, and 11 show Applicants' titanium oxide moieties first placed on the target surface, followed by octadecylaminodimethyltrihydroxysilylpropylammonium chloride.<u style="single">6</u>Is placed on the coating of the titanium oxide portion formed earlier to demonstrate that a self-contaminating decontamination surface is generated.</p><p> Procedure Put on sterile gloves.</p><p> Test coupons are prepared by first wiping and drying with ISP alcohol.</p><p> Clean the test coupon with a surface cleaner using a microfiber cloth.</p><p> Hold the sprayer approximately 8 inches away from the surface to be cleaned.</p><p> Keep spraying for 1-3 minutes, wipe it off, continue spraying cleaner for longer if the area is extremely dirty, or do a second spray and wipe.</p><p> Wipe the surface with a clean, damp sponge or cloth.</p><p> Allow the surface to dry completely.</p><p> Test the coupon for consistency with gloved hands.</p><p> First coat-Applicants' application of titanium oxide moieties. The applicant's titanium oxide portion is added to the applicator container.</p><p> Tighten the liquid hose / bottle cap assembly onto the container.</p><p> Connect the air hose from the compressor to the air fitting on the spray applicator.</p><p> Connect the liquid hose to the liquid fitting on the spray applicator.</p><p> Plug the power cord into the appropriate receptacle. Switch on the air compressor.</p><p> The optimum spray distance is at least 36 to 48 inches away from the target surface.</p><p> Hold the spray gun at right angles to the target surface and spray.</p><p> The target surface should be barely shiny by spraying. Do not supersaturate the surface.</p><p> Rinse the spray gun with distilled water and then apply the applicant's titanium oxide portion (once for each product unless two sprayers are used).</p><p> Second coat-application of organosilane Octadecylaminodimethyltrihydroxysilylpropylammonium chloride<u style="single">6</u>To the applicator container.</p><p> Tighten the liquid hose / bottle cap assembly onto the container.</p><p> Connect the air hose from the compressor to the air fitting on the spray applicator.</p><p> Connect the liquid hose to the liquid fitting on the spray applicator.</p><p> Plug the power cord into the appropriate receptacle. Switch on the air compressor.</p><p> The optimum spray distance is at least 36 to 48 inches away from the target surface.</p><p> Hold the spray gun at right angles to the target surface and spray.</p><p> The target surface should be barely shiny by spraying. Do not supersaturate the surface.</p><p> Allow the surface to dry completely.</p><p> Clean the spray gun with distilled water on each day of use according to the manufacturer's specifications.<tables num="9"><img file="JP2019007011A_D0019.tif" /></tables><tables num="10"><img file="JP2019007011A_D0020.tif" /></tables><tables num="11"><img file="JP2019007011A_D0021.tif" /></tables></p><p> (Example III) In this Example III, a mixture of the applicant's organosilane and the applicant's titanium oxide moiety is simultaneously placed on the surface of a plurality of test coupons. More specifically, in this Example III, Applicants were asked to use their titanium oxide moiety and octadecylaminodimethyltrihydroxysilylpropylammonium chloride.<u style="single">6</u>Are placed on the surface of each test coupon at the same time.</p><p> This Example III test coupon was prepared using the procedures listed directly below. In certain embodiments, the processed coupons were stored for at least 4 weeks and then inoculated with various organisms.</p><p> Table 12 lists efficacy data for processed coupons after inoculation with E. coli. Table 13 lists efficacy data for processed coupons after inoculation with MS-2. Table 14 lists efficacy data for processed coupons after inoculation with MRSA.</p><p> In summary, Tables 12, 13 and 14 demonstrate that the simultaneous placement of the Applicants' titanium-oxygen moiety and the Applicants' organosilanes on the target surface results in a self-contamination decontamination surface.</p><p> Procedure Put on sterile gloves.</p><p> Test coupons are prepared by first wiping and drying with ISP alcohol.</p><p> Clean the test coupon with a surface cleaner using a microfiber cloth.</p><p> Hold the sprayer approximately 8 inches away from the surface to be cleaned.</p><p> Keep spraying for 1-3 minutes, wipe it off, continue spraying cleaner for longer if the area is extremely dirty, or do a second spray and wipe.</p><p> Wipe the surface with a clean, damp sponge or cloth.</p><p> Allow the surface to dry completely.</p><p> Test the coupon for consistency with gloved hands.</p><p> Preparation of Combined Solutions In a measured container, combine an aqueous mixture of 50% octadecylaminodimethyltrihydroxysilylpropylammonium chloride with an aqueous mixture of 50% of the applicant's titanium oxide moiety.</p><p> Mix thoroughly.</p><p> The mixture from the coating [0092] is added to the applicator container.</p><p> Tighten the liquid hose / bottle cap assembly onto the container.</p><p> Connect the air hose from the compressor to the air fitting on the spray applicator.</p><p> Connect the liquid hose to the liquid fitting on the spray applicator.</p><p> Plug the power cord into the appropriate receptacle. Switch on the air compressor.</p><p> The optimum spray distance is at least 36 to 48 inches away from the target surface.</p><p> Hold the spray gun at right angles to the target surface and spray.</p><p> The target surface should be barely shiny by spraying. Do not supersaturate the surface.</p><p> Allow the surface to dry completely.</p><p> Clean the spray gun with distilled water on each day of use according to the manufacturer's specifications.<tables num="12"><img file="JP2019007011A_D0022.tif" /></tables><tables num="13"><img file="JP2019007011A_D0023.tif" /></tables><tables num="14"><img file="JP2019007011A_D0024.tif" /></tables></p><p> (Example IV) This Example IV utilizes water (3-aminopropyl) trimethoxysilane as the only organosilane. In such cases, this Example VI does not utilize an organosilane (s) containing a quaternary ammonium moiety. (3-Aminopropyl) trimethoxysilane, when mixed with water, (3-aminopropyl) trihydroxysilane<u style="single">7</u>Hydrolyzes rapidly.<chemistry num="7"><img file="JP2019007011A_D0025.tif" /></chemistry></p><p> The test coupons for Example IV were prepared using the procedures listed directly below. In certain embodiments, the processed coupons were stored for at least 4 weeks and then inoculated with various organisms.</p><p> Applicants used the applicant's two-step spray coating protocol described below to evaporate water from the spray-deposited titanium oxide moiety and to spray-deposit aqueous (3-aminopropyl) tri. After evaporating water from the hydroxysilane, the combined weight of the applicant's titanium oxide portion placed on the treated surface and the (3-aminopropyl) trihydroxysilane is 1.22 mg / in.²I found that it was measured.</p><p> Applicants have applied (3-aminopropyl) trihydroxysilane and their titanium oxide moiety by spray deposition or dip coating on the bandage before using the wound covering bandage. I found that it can be placed. As will be appreciated by those skilled in the art, bandages are sterile pads or compression gauze applied to the wound to promote healing and / or prevent further damage. Bandages are designed to be in direct contact with the wound and are distinguished from the bandages most often used to hold the bandage in place. In certain embodiments, Applicants' wound bandages include: alginates and other fibrous gelled bandages, including ropes and sheets, composite bandages, adhesive edges. Foam bandages with and without adhesive edges, gauze with and without adhesive edges, hydrophilic colloids, special absorbent bandages with and without adhesive edges, transparent films, collagen bandage sheets and ropes, with adhesive edges And not equipped with hydrogel sheets, cotton packing strips, roll gauze, paper tape, silk tape, compression bandages (elastic, knitted / woven), self-adhesive bandages (elastic, unwoven / unwoven).</p><p> Tables 15, 16 and 17 list efficacy data for processed coupons after inoculation with E. coli. In summary, Tables 15, 16 and 17 show a (3-aminopropyl) trihydroxysilane coating placed on the target surface, followed by TiO.₂Is placed on its (3-aminopropyl) trihydroxysilane coating to demonstrate that a self-contaminating decontaminated surface is produced.</p><p> Procedure Put on sterile gloves.</p><p> Test coupons are prepared by first wiping and drying with ISP alcohol.</p><p> Clean the test coupon with a surface cleaner using a microfiber cloth.</p><p> Hold the sprayer approximately 8 inches away from the surface to be cleaned.</p><p> Keep spraying for 1-3 minutes, wipe it off, continue spraying cleaner for longer if the area is extremely dirty, or do a second spray and wipe.</p><p> Wipe the surface with a clean, damp sponge or cloth.</p><p> Allow the surface to dry completely.</p><p> Test the coupon for consistency with gloved hands.</p><p> Preparation of Dilutions for (3-Aminopropyl) Triethoxysilane Prepare a 10% methanol (MeOH) solution of (3-aminopropyl) triethoxysilane (10 ml silane in 100 ml MeOH).</p><p> Triethanolamine is prepared as a 10% MeOH solution.</p><p> Combine the triethanolamine solution with the (3-aminopropyl) triethoxysilane solution in a 1: 1 ratio on a stirring plate at room temperature (ie, 100 ml of triethanolamine solution with 100 ml of (3-aminopropyl)). Add to triethoxysilane solution).</p><p> The mixture from the application of the first coat- (3-aminopropyl) triethoxysilane [0116] is added to the applicator container.</p><p> Tighten the liquid hose / bottle cap assembly onto the container.</p><p> Connect the air hose from the compressor to the air fitting on the spray applicator.</p><p> Connect the liquid hose to the liquid fitting on the spray applicator.</p><p> Plug the power cord into the appropriate receptacle. Switch on the air compressor.</p><p> The optimum spray distance is at least 36 to 48 inches away from the target surface.</p><p> Hold the spray gun at right angles to the target surface and spray.</p><p> The target surface should be barely shiny by spraying. Do not supersaturate the surface.</p><p> Rinse the spray gun with distilled water and then apply the applicant's titanium oxide portion (once for each product unless two sprayers are used).</p><p> Second coat-Applicants' application of titanium oxide moieties. The applicant's titanium oxide portion is added to the applicator container.</p><p> Tighten the liquid hose / bottle cap assembly onto the container.</p><p> Connect the air hose from the compressor to the air fitting on the spray applicator.</p><p> Connect the liquid hose to the liquid fitting on the spray applicator.</p><p> Plug the power cord into the appropriate receptacle. Switch on the air compressor.</p><p> The optimum spray distance is at least 36 to 48 inches away from the target surface.</p><p> Hold the spray gun at right angles to the target surface and spray.</p><p> The target surface should be barely shiny by spraying. Do not supersaturate the surface.</p><p> Allow the surface to dry completely.</p><p> Clean the spray gun with distilled water on each day of use according to the manufacturer's specifications.<tables num="15"><img file="JP2019007011A_D0026.tif" /></tables><tables num="16"><img file="JP2019007011A_D0027.tif" /></tables><tables num="17"><img file="JP2019007011A_D0028.tif" /></tables></p><p> (Example V) In this Example V, (3-chloropropyl) trimethoxysilane is mixed with water. (3-Chloropropyl) trimethoxysilane, when mixed with water, (3-chloropropyl) trihydroxysilane<u style="single">8</u>Hydrolyzes immediately.<chemistry num="8"><img file="JP2019007011A_D0029.tif" /></chemistry></p><p> In such a case, this Example V does not utilize the organosilane (s) containing the quaternary ammonium moiety. Furthermore, this Example VII does not utilize organosilanes (s) containing amino moieties.</p><p> The test coupons for Example V were prepared using the procedures listed directly below. In certain embodiments, the processed coupons were stored for at least 4 weeks and then inoculated with various organisms.</p><p> Applicants can spray (3-chloropropyl) trihydroxysilane and their titanium oxide moiety onto the bandage before using the wound covering bandage or by dip coating. I found that it can be placed. As will be appreciated by those skilled in the art, bandages are sterile pads or compression gauze applied to the wound to promote healing and / or prevent further damage. Bandages are designed to be in direct contact with the wound and are distinguished from the bandages most often used to hold the bandage in place. In certain embodiments, Applicants' wound bandages include: alginates and other fibrous gelled bandages, including ropes and sheets, composite bandages, adhesive edges. Foam bandages with and without adhesive edges, gauze with and without adhesive edges, hydrophilic colloids, special absorbent bandages with and without adhesive edges, transparent films, collagen bandage sheets and ropes, with adhesive edges And not equipped with hydrogel sheets, cotton packing strips, roll gauze, paper tape, silk tape, compression bandages (elastic, knitted / woven), self-adhesive bandages (elastic, unwoven / unwoven).</p><p> Tables 18, 19 and 20 list efficacy data for processed coupons after inoculation with E. coli. In summary, Tables 18, 19, and 20 show that the (3-chloropropyl) trihydroxysilane coating was placed on the target surface, after which the applicants' titanium oxide moieties were placed on the (3-chloropropyl) trihydroxysilane coating. Demonstrate that a self-decontaminating surface is generated by placing in.</p><p> Procedure Put on sterile gloves.</p><p> Test coupons are prepared by first wiping and drying with ISP alcohol.</p><p> Clean the test coupon with a surface cleaner using a microfiber cloth.</p><p> Hold the sprayer approximately 8 inches away from the surface to be cleaned.</p><p> Keep spraying for 1-3 minutes, wipe it off, continue spraying cleaner for longer if the area is extremely dirty, or do a second spray and wipe.</p><p> Wipe the surface with a clean, damp sponge or cloth.</p><p> Allow the surface to dry completely.</p><p> Test the coupon for consistency with gloved hands.</p><p> Preparation of Organosilane Dilutes for (3-Chloropropyl) Trimethoxysilane Prepare a 10% methanol (MeOH) solution of (3-chloropropyl) trimethoxysilane (10 ml silane in 100 ml MeOH).</p><p> Prepare a triethanolamine solution as a 10% MeOH solution.</p><p> Mix the triethanolamine solution with the (3-chloropropyl) trimethoxysilane solution in a 1: 1 ratio on a stirring plate at room temperature (ie, 100 ml of triethanolamine, 100 ml of (3-chloro). Propyl) Add to trimethoxysilane).</p><p> The mixture of the first coat-application of (3-chloropropyl) trimethoxysilane [0149] is added to the applicator container.</p><p> Tighten the liquid hose / bottle cap assembly onto the container.</p><p> Connect the air hose from the compressor to the air fitting on the spray applicator.</p><p> Connect the liquid hose to the liquid fitting on the spray applicator.</p><p> Plug the power cord into the appropriate receptacle. Switch on the air compressor.</p><p> The optimum spray distance is at least 36 to 48 inches away from the target surface.</p><p> Hold the spray gun at right angles to the target surface and spray.</p><p> The target surface should be barely shiny by spraying. Do not supersaturate the surface.</p><p> Rinse the spray gun with distilled water and then apply the applicant's titanium oxide portion (once for each product unless two sprayers are used).</p><p> Second coat-Applicants' application of titanium oxide moieties. The applicant's titanium oxide portion is added to the applicator container.</p><p> Tighten the liquid hose / bottle cap assembly onto the container.</p><p> Connect the air hose from the compressor to the air fitting on the spray applicator.</p><p> Connect the liquid hose to the liquid fitting on the spray applicator.</p><p> Plug the power cord into the appropriate receptacle. Switch on the air compressor.</p><p> The optimum spray distance is at least 36 to 48 inches away from the target surface.</p><p> Hold the spray gun at right angles to the target surface and spray.</p><p> The target surface should be barely shiny by spraying. Do not supersaturate the surface.</p><p> Allow the surface to dry completely.</p><p> Clean the spray gun with distilled water on each day of use according to the manufacturer's specifications.<tables num="18"><img file="JP2019007011A_D0030.tif" /></tables><tables num="19"><img file="JP2019007011A_D0031.tif" /></tables><tables num="20"><img file="JP2019007011A_D0032.tif" /></tables></p><p> (Example VI) This Example VI utilizes three coating formulations that do not contain any titanium oxide-containing compounds. The first of the three coating formulations identified as ABS 2015E in this Example VI is octadecylaminodimethyltrihydroxysilylpropylammonium chloride as an organosilane.<u style="single">6</u>To use. The second of the three coating formulations identified in this Example VI as ABS 2020E is the (3-aminopropyl) trihydroxysilane as an organosilane.<u style="single">7</u>To use. The third of the three coating formulations identified in this Example VI as ABS 2030E is the (3-chloropropyl) trihydroxysilane as an organosilane.<u style="single">8</u>To use.</p><p> The method of Example IV from paragraph [0105] to paragraph [0124] relating to the spray deposition of silane on the test coupon was utilized in this Example VI. The methods from paragraph [0125] to paragraph [0134] on the spray deposition of titanium-oxygen moieties were not utilized in this Example VI.<tables num="21"><img file="JP2019007011A_D0033.tif" /></tables><tables num="22"><img file="JP2019007011A_D0034.tif" /></tables><tables num="23"><img file="JP2019007011A_D0035.tif" /></tables></p><p> Table 21 lists CFU / mL data for each of the three coating formulations, and each formulation did not contain one or more titanium oxide moieties. Table 22 lists the Log reduction data for the three formulations evaluated, with each formulation not containing one or more titanium oxide moieties. Table 23 lists the reduced percent data for the three formulations used, and each formulation did not contain one or more titanium oxide moieties.</p><p> In the coating formulations ABS 2015E, 2020E, and 2030E, one or more polymer species are formed on the treated surface, depending on the stoichiometry of the mixture of triethanolamine and organosilanes. In certain embodiments, triethanolamine, as shown in Reaction Scheme 2.<u style="single">9</u>And organosilane<u style="single">1</u>Reacts with a linear polymer<u style="single">10</u>To form.<chemistry num="9"><img file="JP2019007011A_D0036.tif" /></chemistry></p><p> In other embodiments, triethanolamine, as shown in Reaction Scheme 3.<u style="single">9</u>And organosilane<u style="single">1</u>Reacts with a branched polymer<u style="single">11</u>To form.<chemistry num="10"><img file="JP2019007011A_D0037.tif" /></chemistry></p><p> In other embodiments, triethanolamine, as shown in Reaction Scheme 4.<u style="single">9</u>And organosilane<u style="single">1</u>Reacts to crosslink the polymer<u style="single">12</u>To form.<chemistry num="11"><img file="JP2019007011A_D0038.tif" /></chemistry></p><p> In certain embodiments, the applicant's organosilanes are tetraethyl orthosilicates.<u style="single">13</u>including. In certain embodiments, as shown in Reaction Scheme 5, the starting material<u style="single">9</u>and<u style="single">13</u>According to the stoichiometry of the applicants, the crosslinked polymer material<u style="single">14</u>But tetraethyl orthosilicate<u style="single">13</u>And triethanolamine<u style="single">9</u>It is formed by the reaction of. Reaction scheme 5 shows a single Si atom having four different polymer chains resulting from it. For those skilled in the art, the applicants' crosslinked polymer materials<u style="single">14</u>Will be understood to contain very high crosslink densities.<chemistry num="12"><img file="JP2019007011A_D0039.tif" /></chemistry></p><p> In certain embodiments, as shown in Reaction Scheme 6 and starting material<u style="single">15</u>and<u style="single">13</u>According to the stoichiometry of the applicants, the crosslinked polymer material<u style="single">16</u>Is tetraethyl orthosilicate<u style="single">13</u>And diethanolamine<u style="single">13</u>It is formed by the reaction of. Reaction scheme 6 shows a single Si atom having four different polymer chains resulting from it. For those skilled in the art, the applicants' crosslinked polymer materials<u style="single">16</u>Will be understood to contain very high crosslink densities.<chemistry num="13"><img file="JP2019007011A_D0040.tif" /></chemistry></p><p> (Example VII) Stainless steel carrier, 7.5% of 3 different cholines<u style="single">16</u>One of the compounds is H₂Coated with the solution contained in O, where R3 is -H and -CO-CH₃Selected from the group consisting of. The choline used contained choline chloride, choline hydrogen tartrate, and acetylcholine chloride. The carrier was coated by immersing it in solution using forceps and drip drying overnight. The carrier was not yet completely dry after a 24-hour drying time. 20 microliters of O / N culture of E. coli 25592 (growing at 37 C for 18 hours) was added to each carrier. After inoculation of the carrier, the carrier was swabbed with D / E neutralized broth and processed for a zero hour time point. This was repeated at 1 and 4 hours.<chemistry num="14"><img file="JP2019007011A_D0041.tif" /></chemistry></p><p> The collected samples were then diluted in PBS, 100 microliters were plate-cultured on a TSA plate, left overnight at 37 ° C, then counted to calculate cfu / ml. All carriers were tested in duplicate and two experiments were performed in tandem (data tables A and B). All data are expressed as mean +/- SEM (standard error) where applicable.</p><p> When calculated against a timed control, choline hydrogen tartrate showed the highest surface mortality rate, resulting in a 2.39 log reduction in bacteria. Acetylcholine chloride and choline chloride showed 1.85 and 1.40 log reductions, respectively. When compared with the results of aqueous solutions of aminopropyltriethoxysilane (APTES) and choline at the same concentration, it is clear that these solutions are much more antibacterial than choline alone. APTES + choline chloride and APTES + choline hydrogen tartrate showed 3.36 and 3.38 log reductions at 1 hour, respectively.</p><p> Table 24 shows the time T₀The antibacterial efficacy data for the above choline formulations in, ie, immediately after inoculation, are listed. Table 25 lists antibacterial data 1 hour after inoculation.<tables num="24"><img file="JP2019007011A_D0042.tif" /></tables><tables num="25"><img file="JP2019007011A_D0043.tif" /></tables></p><p> Stainless steel carrier with 7.5% and 5% aminopropyltriethoxysilane of each corrin compound₂It was coated with the solution contained in O (ABS-2040 contains choline chloride, while ABS-2041 contains choline hydrogen tartrate). The carrier was coated using an electrostatic sprayer and then dried. The carrier was not yet completely dried even after a drying time of 2 days. A 20 microliter culture of E. coli grown at 37 ° C for 18 hours was added to each carrier. After inoculation of the carrier, the carrier was swabbed with neutralized broth and processed for a zero hour time point. This was repeated at 1 hour.</p><p> The collected sample was then diluted in PBS, 100 microliters were plate-cultured on a TSA plate, left at 37 ° C for O / N, and then counted to calculate cfu / ml. All carriers were tested in duplicate and two experiments were performed in tandem (data tables A and B). All data are expressed as mean +/- SEM (standard error) where applicable. It is noteworthy that the colonies on the choline hydrogen tartrate plate were significantly smaller than the others.</p><p> Table 26 shows the time T₀List antibacterial efficacy data at, i.e. immediately after inoculation. Table 27 lists antibacterial data 1 hour after inoculation. Table 28 lists antibacterial data 4 hours after inoculation.<tables num="26"><img file="JP2019007011A_D0044.tif" /></tables><tables num="27"><img file="JP2019007011A_D0045.tif" /></tables><tables num="28"><img file="JP2019007011A_D0046.tif" /></tables></p><p> Stainless steel carrier with 15% and 5% aminopropyltriethoxysilane of each choline compound₂It was coated with the solution contained in O (ABS-2040 contains choline chloride, while ABS-2041 contains choline hydrogen tartrate). The carrier was coated using an electrostatic sprayer and then dried. The carrier was not yet completely dried even after a drying time of 2 days. 20 microliters of E. coli 25592 culture grown at 37 ° C for 18 hours was added to each carrier. After inoculation of the carrier, the carrier was swabbed with D / E neutralized broth and processed for a zero hour time point. This was repeated at 1 and 4 hours.</p><p> The collected sample was then diluted in PBS, 100 microliters were plate-cultured on a TSA plate, left at 37 ° C for O / N, and then counted to calculate cfu / ml. All carriers were tested in duplicate and two experiments were performed in tandem (data tables A and B). All data are expressed as mean +/- SEM (standard error) where applicable.</p><p> Table 29 shows the time T₀The antibacterial efficacy data in, i.e. immediately after inoculation, are listed. Table 30 lists antibacterial data 1 hour after inoculation. Table 31 lists antibacterial data 4 hours after inoculation.<tables num="29"><img file="JP2019007011A_D0047.tif" /></tables><tables num="30"><img file="JP2019007011A_D0048.tif" /></tables><tables num="31"><img file="JP2019007011A_D0049.tif" /></tables></p><p> Then, referring to FIG. 3, the applicant's sterilization station 300 includes a "through" assembly having two opposing sides 310 and 320 joined by a top 330. In the embodiment shown in FIG. 3, the side 310 comprises a plurality of UV light emitters 311, 312, 313, 314, 315, 316, and 317, the plurality of UV emitters being inside the sterilization station 300, i.e. walking. Facing the space part. In other embodiments, Applicants' sterilization stations 300 include less than 7 UV emitters per side. In yet another embodiment, the applicant's sterilization station comprises more than 7 UV emitters per side.</p><p> The side 320s are similarly formed to include a plurality of UV emitters, each of which faces the interior of the sterilization station 300, i.e. the pedestrian space portion. The plurality of UV emitters arranged inside the side surface 310 are opposed to the plurality of UV emitters arranged inside the side surface 320.</p><p> Further in the embodiment shown in FIG. 3, the top portion 330 includes a plurality of UV emitters, i.e. UV emitters 332 and 334, the UV emitters pointing downwards. In other embodiments, the top portion 330 comprises more than two UV emitters.</p><p> The embodiment shown in FIG. 3 shows a doctor-passing sterilization station 300. The doctor is wearing a surgical gown, the outer surface of which various parts are coated with the applicant's coating composition. As the physician passed through the sterilization station 300, multiple UV emitters located on the sides 310 and 320 and multiple UV emitters located on the top 330 were energized, thereby maximizing the photocatalytic action of the applicant's coating. become. The enhanced photocatalytic activity of the coating maximizes the production of high-energy atomic oxygen species on the surface of each portion of the surgical gown, thereby effectively sterilizing the outer surface of all surgical gown articles.</p><p> Although preferred embodiments of the present invention have been described in detail, those skilled in the art can imagine modifications and adaptations of those embodiments without departing from the scope of the invention described herein. Should be understood.</p>