Sanitary napkins with hydrophobic lotions

[Technical field]

【0001】

This application relates to sanitary products such as sanitary napkins for absorbing menstrual blood. More specifically, the present invention relates to a sanitary napkin having a coating of a hydrophobic lotion on the outer surface of the topsheet, the lotion being applied to the wearer's skin due to normal contact and wearer's movements and / or body temperature. It is possible to move to.

[Background technology]

【0002】

Disposable absorbent items such as diapers, training pants, and sanitary napkins with lotioned topsheets are known. It is known that different types of lotions have various skin effects such as prevention or treatment of diaper rash. These lotions can be applied, for example, to the topsheets of absorbent articles and can be transferred to the wearer's skin during use.

【0003】

Unlike many types of disposable absorbent articles, sanitary products such as napkins and panty liners are specifically designed to capture menstrual fluid. Menstrual fluid differs from other exudates such as urine in many important properties such as viscosity. As such, sanitary napkins should differ in composition from products such as baby diapers because they are optimized for maximum absorption of menstrual fluid.

【0004】

The addition of lotion to the topsheet of absorbent articles has been shown to provide the effect of making it easier for infants to defecate. Similarly, lotions on topsheets are known to provide better skin health to babies, such as reducing diaper rash. For example, US Pat. No. 3,489,148 to Duncan et al. Teach baby diapers that include hydrophobic and oleophobic topsheets, the topsheets being partially coated with a discontinuous film of oily material. The main inconvenience of diapers disclosed in Duncan et al. References is that hydrophobic and oleophobic topsheets slow the transfer of urine to the underlying absorbent core. .. This problem associated with Duncan et al. Is even more serious, as menstrual blood is much more viscous than urine.

【0005】

One successful attempt to overcome Duncan's problem is disclosed in US Pat. No. 5,968,025 by Roe et al. Roe et al. Disclose an absorbent article in which the lotion is applied to a hydrophilic topsheet (or a hydrophilic topsheet). The hydrophilic topsheet helps ensure that the urine squirt is properly absorbed into the underlying core rather than, for example, on the sides of the baby diaper.

【0006】

Known attempts to apply lotions to topsheets of absorbent products have primarily targeted baby diapers with the aim of providing better skin health benefits to the baby's buttocks. Little attention has been paid to the specific skin-related problems of adult women when wearing sanitary napkins. The skin in the vulva area of an adult woman is very different from the skin of the baby's buttocks (generally the skin of the buttocks), and the lotion required is also very different. For example, rather than worrying about diaper rash, menstruating women are more interested in hygiene, that is, reducing the amount of menstrual blood remaining on the skin and hair after the use of sanitary napkins. ..

【0007】

The aforementioned attempts to provide lotions on topsheets of absorbent articles have focused on the lotion / topsheet features required to process urine eruptions in a relatively short period of time. However, for sanitary napkins, the behavior of fluids has very different characteristics in relation to physiochemical properties (eg, viscosity, hydrodynamics, etc.) and in volume and time absorbed. For example, the flow of menstruation typically consists of two types. One of these molds is a "dripping" stream, which varies from 0.1 ml to 0.2 ml per hour. The second type is the "squirting" flow, which changes the volume released over a few seconds from a few ml. The erupting stream can result from the accumulation of menstrual blood that accumulates in the vagina, which then comes out of the body through a change in position, such as a transition from a sitting position to a standing state. In any case, even with respect to the erupting flow, the total amount of fluid that needs to be absorbed into the core at a given time is what is needed for other absorbent products, such as baby diapers. Much less. One practical result is that sanitary napkins do not need to be designed to handle the ejected fluid, but more typically treat the fluid by a "sucking" effect.

[Disclosure of Invention]

[Problems to be Solved by the Invention]

【0008】

Therefore, there is a need for improvements to sanitary napkins to improve skin hygiene in menstruating women. In addition, there is a need for sanitary napkins with improved fluid treatment so that more menstrual blood enters and remains in the product and is less on the wearer's skin or hair. In addition, there is a need for sanitary napkins that can change the properties of the skin / product interface when the product is worn.

[Means for solving problems]

【0009】

Disclosing sanitary napkins, the article has a topsheet with a body facing surface, the topsheet having a degree of hydrophobicity. The lotion composition is applied to at least a portion of the topsheet to the body-opposing surface, and the lotion composition has a hydrophobicity equal to or greater than the hydrophobicity of the topsheet. The backsheet is coupled to the topsheet, and the absorbent core is placed between the topsheet and the backsheet.

[Best mode for carrying out the invention]

【0010】

Although the present specification concludes with claims that specifically point out and explicitly claim the subject matter of the invention, it is believed that the invention may be more easily understood by the following description considered with the accompanying drawings.

【0011】

FIG. 1 shows a sanitary napkin or sanitary napkin having a body contact surface 12 including a topsheet 14, a liquid permeable backsheet 16 that binds to the topsheet 14, and an absorbent core 18. Can be a panty liner. The sanitary napkin 10 has a longitudinal axis L and may also be provided with additional features commonly found in napkins, which are known "wings" or "flaps" in the art (illustrated). (Not) and / or a fluid acquisition layer to facilitate fluid transport to the absorbent core 18. Similarly, the topsheet of a sanitary napkin can have a variety of features known in the art. For example, the topsheet 14 can have a passage through it to guide the flow of embossed fluid, and may have an opening through it to assist fluid acquisition. The top sheet 14 of the sanitary product 10 of the present invention has a lotion composition 22 that is placed on the top sheet.

【0012】

The topsheet 14 and lotion composition 22 of the present invention provide significant effects over known topsheets and lotions. In particular, in a preferred embodiment, the topsheet 14 is hydrophobic or made hydrophobic, and the lotion is also hydrophobic. Hydrophobicity can be determined by standard techniques such as measuring the angle created by water droplets on the surface of an equilibrium substance. Generally, for the purposes of the present invention, a substance is considered hydrophobic when the water droplets show an angle of about 60 degrees or more. The fibers are hydrophobic if the film sheet formed from the polymer of the fibers exhibits a contact angle with water greater than 60 degrees, more preferably 75 degrees, and even more preferably greater than about 90 degrees. It is believed that there is. Contact angles as a measure of hydrophobicity are well known in the art, and methods of measuring contact angles are similarly well known. As is well known, a contact angle of more than about 90 degrees is considered hydrophobic, and a contact angle of less than 90 degrees is considered hydrophilic. However, when used herein, contact angles of 60 degrees or higher are considered hydrophobic.

【0013】

The hydrophobicity of the topsheet and lotion can be equal, or the hydrophobicity of the lotion can be greater than the hydrophobicity of the topsheet. During use, the lotion can be transferred from the topsheet to the wearer's skin, which helps to make the skin and hair hydrophobic as well.

【0014】

The effects of the present invention can be evaluated correctly by understanding the difference between the flow of menstrual fluid and, for example, the flow of urine in infants. Infant diaper topsheets are generally taught to be hydrophilic with or without lotion applied, thereby causing sudden urine squirts through the topsheet. It can be obtained with the smallest outflow of fluid into the core. However, it has been found that menstrual fluid, which has a much higher viscosity and a much lower fluid flow, both in quantity and time, can be treated very effectively with a hydrophobic topsheet. While urine can easily drain from hydrophobic topsheets, especially those treated with hydrophobic lotions, these structures provide excellent effects on sanitary napkins for menstruating women. It has been surprisingly found. Another surprising effect is the coating of the skin and hair in the vulva area during use of the sanitary products of the present invention, which results in the skin and hair in the vulva area being cleaner. Yet another effect is that the transfer of lotion to the wearer's skin improves fluid capture of the fluid, which minimizes fluid transport on the wearer's skin and hair away from the exit point. Limit.

【0015】

Although not bound by theory, it is believed that the superior benefits of the present invention are best demonstrated by the combination of hydrophobic topsheets and hydrophobic lotions. Lotions are considered hydrophobic, for example, if the hydrophilic / lipophilic balance (HLB) is 7 or less.

【0016】

The lotion composition of the present invention may contain a selected combination of skin therapeutic agents such as hexamidine, zinc oxide, and niacinamide, which are extremely effective in the prevention and treatment of erythema, malodor, and bacterial skin disorders. It can, and is extremely effective, especially when these lotion compositions are administered to the skin from application on absorbable articles.

【0017】

As used herein, the term "skin therapeutic agent" is such for skin disorders, especially those associated with erythema, malodor, and bacterial infections, when applied locally and internally to the skin. Refers to substances that can also prevent, reduce, and / or eliminate outbreaks. As used herein, the term "skin disease" refers to symptoms associated with irritating, acute, or chronic skin abnormalities. Examples of these symptoms include, but are not limited to, itching, inflammation, rash, burns, punctures, erythema, swelling, hypersensitivity, heat sensation, exfoliation / scales, and foul odors. As used herein, the term "ambient condition" refers to ambient conditions at about 1 atmosphere, about 50% relative humidity, and about 25 ° C.

【0018】

The lotion composition of the present invention may include the elements and limitations of the invention described herein, as well as any additional or optional ingredients, constituents, or restrictions described herein. Can consist of, or can consist essentially of them. All percentages, parts, and ratios are by weight of the total composition unless otherwise specified. All such weights for the listed ingredients are based on the concentration of the specific ingredients and therefore do not include carriers or by-products that may be found in commercially available materials unless otherwise specified.

【0019】

I. Skin Therapeutic Agents: The lotion compositions of the present invention can result from skin disorders, moisture or other body exudates that can result from contact between the skin and moist air over a long period of time. Selected skin treatments that can reduce and eliminate skin diseases resulting from moist human tissue and / or skin diseases resulting from contact between the skin and microbial or bacterial mediators. Contains a relatively low concentration of combination. The phrase "selected combination of dermatological agents" refers to the following combinations: a. Hexamidine, zinc oxide, and niacinamide; b. Hexamidine and zinc oxide; c. Hexamidine and niacinamide.

【0020】

Surprisingly, selected combinations of dermatological agents may be included at lower individual concentrations and still be effective when compared to their use in the prior art. For example, the lotion composition of the present invention contains hexamidine in a concentration of about 0.1% by weight or less, zinc oxide in a concentration of about 1% by weight or less, and niacinamide in a concentration of about 2% by weight or less, and these dermatological agents are contained in a higher concentration. Equal or superior effects can be achieved in the prevention and / or treatment of skin disorders as compared to the known lotion compositions commonly contained in. Similarly, the total effective concentration of selected combinations of dermatological agents in the compositions of the present invention is also relatively low. The total concentration of the selected combination of dermatological agents is from about 0.002% to about 10% by weight, preferably from about 0.01% to about 5% by weight, more preferably from about 0.1% to about 2% by weight of the lotion composition. It is in the range of%.

【0021】

A. Hexamidine: The lotion composition of the present invention contains hexamidine skin remedies from about 0.001% to about 0.1% by weight, about 0.005% to about 0.1% by weight, or even about 0.01% to about 0.1% by weight. Includes in concentrations in the weight% range. Suitable hexamidine dermatological agents for use herein include aromatic diamines that generally conform to the following equations: [0022]

[Chemical 1]<img file="JP2005504591A_D0001.tif" />These aromatic diamines are 4,4'-[1,6-hexanediylbis (oxy)] bisbenzenecarboxyimideamide; 4,4'-(hexamethylenedioxy) dibenzamidine; and 4,4'-diamidino- It is called α, ω-diphenoxyhexane. The most commonly used form of hexamidine is a common type of hexamidine salt, which includes the acetate, salicylate, lactate, gluconate, tartrate, citrate, phosphate, of hexamidine. Examples include borates, nitrates, sulfates, and hydrochlorides. Specific non-limiting examples of hexamidine salts include hexamidine isethionate, hexamidine diisethionate, hexamidine hydrochloride, hexamidine gluconate, and mixtures thereof. Hexamidine acetylate and hexamidine diisethionate are β-hydroxyethanesulfonate salts of hexamidine, which are preferred herein for use as skin therapeutic agents in the prevention and / or treatment of skin disorders. Hexamidine dicethionates are the most preferred hexamidine compounds suitable for use as skin remedies herein, and Laboratories Serolobilogiques (Pulnoy, France) and Cognis -Available from Cognis Incorporation (Cincinnati, Ohio) under the trade name ELASTABHP100.

【0023】

Hexamidine compounds are known as effective skin therapeutic agents capable of suppressing the growth of microorganisms that can lead to irritating and pruritic skin diseases. Therefore, these skin remedies are often also called antibacterial agents. As used herein, the term "antibacterial agent" refers to a substance that functions to disrupt or suppress the growth and metabolism of microorganisms, as well as antibacterial agents, antifungal agents, antiprotozoal agents, anthelmintic agents, and antibacterial agents. Includes the general classification of viral agents.

【0024】

However, low concentrations of hexamidine (less than about 0.1% by weight) can cause irritating skin infections, especially when small amounts of hexamidine are combined with low concentrations of zinc oxide and / or other antimicrobial agents such as niacinamide. It has been found to provide improved reduction and / or prevention. The combination of hexamidine and zinc oxide and / or niacinamide can be administered locally and internally at a total concentration less than the effective amount of these individual component application doses. As used herein, the term "effective amount" is used to reduce and / or prevent any prominent or unacceptable skin abnormalities that cause irritating, acute, or chronic symptoms, including itching and inflammation. In, refers to an amount that provides a therapeutic effect with minimal or no rejection.

【0025】

Other aromatic diamines are also suitable for use as the skin remedies herein. These compounds include butamidine and its derivatives, including butamidine isethionate; pentamidine, and pentamidine and its derivatives, including pentamidine hydrochloride; dibromopropamidine, including dibromopropamidine, isetionate. (Dibromopropamidine) and its derivatives; stillbamidin and its derivatives, including hydroxystilbamide, stillbamidin dihydrochloride, and stillbamidin isethionate; diaminodiamidine and its derivatives; and mixtures thereof.

【0026】

B. Zinc Oxide: The lotion composition of the present invention contains zinc oxide dermatological agent, about 0.001% to about 10% by weight, preferably about 0.005% to about 5% by weight, more preferably about 0.005% by weight. It is contained in a concentration in the range of% to about 2% by weight, most preferably about 0.01% by weight to about 1% by weight. Zinc oxide skin remedies are single oxidation, provided that single or combined zinc oxide can be easily combined with hexamidine and niacinamide skin remedies to provide antibacterial effects. It may be included in the composition as a zinc compound or as a combination of zinc oxide.

【0027】

Suitable zinc oxide dermatological agents for use herein include inorganic white powders and yellowish white powders conforming to the formula ZnO, which are registered in the 11th edition of the Merck Index. More details are given on page 10050, page 1599 (1989). Some particularly useful forms of zinc oxide are manufactured with an average particle size diameter ranging from about 1 nm (nanometers) to about 10 μm (micrometers), or about 10 nm to about 1 μm, or even about 20 nm to about 500 nm. And commercially available. Surprisingly, the use of zinc oxide of the relatively small nanoparticle diameter size described above is the result of the transfer of zinc oxide-containing emollients from the topsheet of the absorbent article to the wearer's body during product use. The inventor has found that it occurs and avoids unwanted skin or hair whitening. If the product is a panty liner, sanitary napkin, incontinence pants, or other absorbent article intended for use by adults with hair in areas where the lotion composition will move. This is especially beneficial.

【0028】

Commercially available zinc oxide includes white zinc oxide powder sold under the trade name ULTRFINE 350, which is commercially available from Kobo Incorporation in South Plainfield, New Jersey. Has been done. Other suitable zinc oxide substances include premixes of dispersants such as zinc oxide and polyhydroxystearic acid, which are Uniqema Incorporation (Wilimington, Delaware). , Delaware)), available under the trade name Arlecel® P100; and a premix of zinc oxide and isononyl isonanoanoate dispersant, which is Ikeda It is available from Incorporation (Island Park, New York) under the trade name Salacos® 99.

【0029】

C. Niacinamide: The lotion composition of the present invention comprises a niacinamide dermatological agent as a single niacinamide or a combination of niacinamide, from about 0.01% to about 10% by weight, preferably about 0.05% of the lotion composition. It is contained in a total concentration of niacinamide in the range of% to about 5% by weight, more preferably about 0.2% by weight to about 2% by weight. Niacinamide dermatological agents provide conditioning effects and enhance the effectiveness of niacinamide dermatological agents in controlling skin diseases.

【0030】

Non-limiting examples of niacinamide skin therapeutic agents suitable for use in the lotion composition of the present invention include niacinamide compounds which are amide derivatives of nicotinamide and generally conform to the following formula: [0031]

[Chemical 2]<img file="JP2005504591A_D0002.tif" />Niacinamide and nicotinamide are B vitamins₃And vitamin B₅On the other hand, niacinamide is commonly used in the active form. Niacinamide derivatives, including salt derivatives, are also suitable for use herein as skin remedies. Non-limiting specific examples of suitable niacinamide derivatives include nicotin uric acid and nicotinyl hydroxamic acid.

【0032】

The niacinamide dermatological agent can also be included in the composition as an acidified niacinamide compound. The process of acidifying niacinamide compounds is rudimentary to those skilled in the art, and one such technique is to dissolve niacinamide in an alcohol solution, equivalent molars of fatty acids such as stearic acid with stirring. (For example, 1 part of niacinamide is mixed with 2.4 parts of stearic acid), and then the mixture is air dried until the alcohol evaporates. A suitable stearic acid compound that can be used in the acidification process of niacinamide is stearic acid, marketed under the trade name Emersol® 150, which is available from Cognis Corporation. ..

【0033】

Examples of niacinamide compounds described above are well known in the art and are from a number of sources, such as the Sigma Chemical Company (St Louis, Missouri); ICN Biomedical. The Incorporation (ICN Biomedicals, Incorporation) (Irvin, CA); Aldrich Chemical Company (Milwaukee, Wisconsin, St. Louis); and Em Industries HHN (Em) Industries HHN) (Hawthorne, New York).

【0034】

D. Optional Ingredients: Non-limiting examples of any suitable skin therapeutic active agent useful in the present invention include allantin; aluminum hydroxide gel; caramine; cysteine hydrochloride; racemic methionine; sodium bicarbonate; vitamin C and its thereof. Derivatives; Protease Inhibitors Containing Serine Proteases, Metalloproteases, Cysteine Proteases, Aspartyl Proteases, Peptidases, and Phenylsulfonyl Florides; Lipases; Esterases Containing Diesterases; Ureases; Amylases; Elastases; Examples thereof include vegetation extracts containing chamomile; and mixtures thereof. Guanidine benzoic acid and its salts and derivatives are described in more detail in US Pat. No. 5,376,655 issued to Imaki et al. On December 27, 1994. These other suitable skin therapeutic active substances are typically contained in concentrations ranging from about 0.001% to about 10% by weight of the lotion composition.

【0035】

Moreover, one or more optional constituents known or otherwise effective for use in the lotion composition are physically and chemically compatible with essential skin therapeutic and carrier constituents, or product stability. It can also be included under the condition that it does not excessively impair the aesthetics, or performance. These optional constituents are typically contained in concentrations ranging from about 0.001% to about 20% by weight of the composition, and water, skin conditioning agents, fragrances, deodorants, opaque agents, astringents, preservatives. , Emulsifiers, film-forming agents, stabilizers, proteins, lecithin, urea, colloidal oatmeal, pH regulators, and use on human skin under 21 C.FR §347 by the US Food and Drug Administration (FDA) Examples include other substances in the monograph that are considered safe for. Other optional constituents used in the lotion composition of the present invention include fats or oils, or essential oils. These oils are about 0. , Hardened palm oil, hardened peanut oil, hardened shark liver oil, hardened soybean oil, hardened tallow, 315 hardened vegetable oil, lard, lauric acid / palmitic acid / oleic acid triglyceride, lanolin and lanolin derivatives, Lesquerella Oil, macadamia nuts Oil, maleate soybean oil, Meadowfoarn seed oil, Menhaden oil, mink oil, moringa oil, maltiera oil, oleic acid / linoleic acid triglyceride, oleic acid / palmitic acid / lauric acid / myristic acid / linoleic acid triglyceride , Oleo stearine, olive husk oil, olive oil, ornental lipid, palm kernel oil, palm oil, 320 peach kernel oil, peanut oil, pentadesma butter, phospholipid, pistachio nut oil, rapeseed oil, rice bran Oil, Benibana oil, sesame oil, shark liver oil, shea butter, soybean oil, sphingolipid, sunflower seed oil, sweet almond oil, tall oil, tallow, tribehenin, tricaprin, tricapriline, triheptanoin, C10 fatty acids: arachidic acid, Behenic acid, capric acid, caproic acid, 330 capric acid, Coconut Acid, cornic acid, Cottonseed Acid, hardened Coconut Acid, hardened menhardenic acid, hardened taro acid, hydroxystearic acid , Isostearic acid, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, palm nucleic acid, pelargonic acid, ricinolic acid, soy acid, stearic acid, taro acid, undecanoic acid, undecylene acid, Substances such as flour blastic acid, as well as mixtures thereof. Specific optional lotion conditioning agents found to be useful in the present invention include panthenol, glycerin, and chamomile oil, which are described in detail below. Arakidic acid, behenic acid, capric acid, caproic acid, 330 capric acid, Coconut Acid, corn acid, Cottonseed Acid, hardened Coconut Acid, hardened menhardenic acid, hardened taroic acid, Hydroxystearic acid, isostearic acid, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, palm nucleic acid, pelargonic acid, ricinolic acid, soy acid, stearic acid, taro acid, undecanoic acid, Examples include undesylene acid, flour blastic acid, and other substances such as mixtures thereof. Specific optional lotion conditioning agents found to be useful in the present invention include panthenol, glycerin, and chamomile oil, which are described in detail below.

【0036】

Panthenol: Panthenol, when included, typically comprises from about 0.001% to about 10% by weight of the lotion composition, preferably from about 0.005% to about 5% by weight, more preferably from about 0.05% by weight to about. Consists of 1% by weight. Any panthenol skin conditioning agent provides a skin softening effect that can leave the skin smooth, soothing, and soft to the touch during and after the interaction of the skin tissue with the skin remedy. The lotion composition of the present invention can contain a single panthenol compound or a mixture of panthenol compounds.

【0037】

Non-limiting examples of panthenol include panthenol compounds which are alcohol or ester derivatives of pantothenic acid. Pantothenic acid is a member of the B complex lineage, often vitamin B₃Is called. Like pantothenic acid, panthenol alcohol derivatives of this acid exist as stereoisomers, eg, as D (+), L (-), racemic compounds, and mixtures of D (+) and L (-) forms. it can. Specific examples of panthenol include, but are not limited to, D-panthenol (aka dexpanthenol) and dl-panthenol. Panthenol is described in more detail in the 11th edition of the Merck Index, Registration 2924, p. 464 (1989), which is incorporated herein by reference. An example of a commercially available panthenol is Roche Vitamins Incorporation (Nutley, NJ), a subsidiary of F. Hoffman LaRoche, Ltd. )) D-Panthenol available from.

【0038】

Glycerin: When a lotion composition is included, any preferred glycerin skin conditioning agent is applied to the lotion composition from about 0.01% to about 10% by weight, preferably from about 0.02% to about 5% by weight, more preferably. It is contained in a concentration in the range of about 0.05% by weight to about 2% by weight. Any glycerin skin conditioning agent also provides a emollient effect such as smooth, soothing, and soft skin feel, as well as a dispersant for niacinamide skin remedies.

【0039】

Glycerin is a C3 monohydric alcohol, also known as glycerol and 1,2,3-propanetriol. Glycerin derivatives are also suitable for use as any skin conditioning agent herein, such derivatives include polyglycerol having about 2 to about 16 repeating glycerol moieties. Specific examples of suitable glycerin skin conditioning agents are glycerin, USP Kosher®, which is commercially available from Procter &amp; Gamble Company, located in Cincinnati, Ohio. ..

【0040】

Chamomile: The lotion composition is preferably any chamomile oil, from about 0.0001% to about 10% by weight, preferably from about 0.001% to about 5% by weight, more preferably from about 0.005% to about 2% by weight. Includes in the range of%. Any chamomile oil skin conditioning agent also provides skin effects such as analgesia. Chamomile oil is commonly prepared as an oil extract of chamomile flowers. Examples of commercially available chamomile oils include Phytoconcentrol chamomile, which is available from Dragoco Incorporation (Totowa, NJ).

【0041】

II. Carriers: The lotion compositions of the present invention include carriers for dermatological agents. The carriers are contained in the composition as a single carrier or combination of carrier components, provided that the total concentration of carriers is sufficient to provide the transfer and / or transfer of the skin therapeutic agent onto the skin. Can be included. The carrier can be a liquid, solid, or semi-solid carrier material, or a combination of these materials, in which the resulting carrier is the treatment of choice for the resulting carrier system. It is subject to the condition that a uniform mixture or solution is formed at the temperature and at the treatment temperature for combining the carrier and the dermatological agent when formulating the lotion compositions herein. The processing temperature of the carrier system is typically about 60 ° C to about 90 ° C, more typically about 70 ° C to about 85 ° C, and even more typically about 70 ° C to about 80 °. It is in the range of C.

【0042】

The lotion composition of the present invention typically contains carriers from about 60% to about 99.9% by weight, preferably from about 70% to about 98% by weight, more preferably from about 80% to about 97% by weight. Included in total carrier concentration in the range by weight%. Suitable carrier compounds include petroleum hydrocarbons having about 4 to about 32 carbon atoms, fatty alcohols having about 12 to about 24 carbon atoms, polysiloxane compounds, fatty acid esters, alkyl ethoxylates, about 1 to about 1 to about. Lower alcohols with 6 carbon atoms, low molecular weight glycols and polyhydric alcohols, fatty alcohol ethers with about 12 to about 28 carbon atoms in their fat chains, lanolin and its derivatives, acetoglycides and ethoxylates of C12 to C28 fatty acids. Examples thereof include glycerides including chemical glycerides and derivatives thereof, and mixtures thereof. Alternatively, in combination, the carrier can also be composed of a polysiloxane compound, and in non-limiting examples, dimethicone (1-100,000,000 centistoke), cyclomethicone, alkylated silicone (hair conditioning agent), silicone rubber. , Silicone gels, silicone waxes, silicone copolymers (vinyl dimethicone polymers, phenylvinyl dimethicone polymers, alkylated silicone polymers, polyethylene oxide / silicone copolymers, polyethylene oxide / alkyl silicone copolymers), and mixtures thereof.

【0043】

Non-limiting examples of suitable petroleum-based hydrocarbons having about 4 to about 32 carbon atoms include mineral oil, petrolatum, isoparaffin, various other molecular chain hydrocarbons, and combinations thereof. Mineral oil is also known as "liquid petrolatum" and usually refers to a less viscous mixture of hydrocarbons with about 16 to about 20 carbon atoms. Vaseline is also known as "mineral wax", "petroleum jelly", and "mineral jelly" and refers to a more viscous mixture of hydrocarbons, usually having about 16 to about 32 carbon atoms. Commercial examples of petrolatum include petrolatum sold as Protopet® 1S, which is available from Witco Corporation in Greenwich, Connecticut. It is possible.

【0044】

Non-limiting examples of suitable fatty alcohols having about 12 to about 24 carbon atoms include saturated unsubstituted monohydric alcohols or combinations thereof, which are less than about 110 ° C, preferably about 45 °. It has a melting point of C ~ about 110 ° C. Specific examples of the fatty alcohol carrier used in the lotion composition of the present invention include cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, arachidyl alcohol, lignocaryl alcohol, and combinations thereof. Not limited. An example of a commercially available cetearyl alcohol is Stenol 1822, and a behenyl alcohol is Lanette 22, both of which are available from Cognis Corporation in Cincinnati, Ohio. is there.

【0045】

Non-limiting examples of suitable fatty acid esters include C₁₂~ C₂₈Fatty acids and short chains (C₁~ C₈, Preferably C₁~ C₃) Mixture of monohydric alcohol, preferably C₁₆~ C₂₄Saturated fatty acids and short chains (C₁~ C₈, Preferably C₁~ C₃) Fatty acid esters obtained from a mixture of monohydric alcohols. Representative examples of such esters include methyl palmitate, methyl stearate, isopropyl laurate, isopropyl myristate, isopropyl palmitate, ethylhexyl palmitate, and mixtures thereof. Suitable fatty acid esters are also longer chain fatty alcohols (C)₁₂~ C₂₈, Preferably C₁₂~ C₁₆), And shorter chain fatty acid esters such as lactic acid, specific examples of which include lauryl lactate and cetyl lactate.

【0046】

A non-limiting example of a suitable alkyl ethoxylate is C, which has an average degree of ethoxylation of about 2 to about 30.₁₂~ C₂₂Fat alcohol ethoxylates can be mentioned. Non-limiting examples of suitable lower alcohols having about 1 to about 6 carbon atoms include ethanol, isopropanol, butanediol, 1,2,4-butanediol, 1,2 hexanediol, ether propanol, and mixtures thereof. Can be mentioned. Non-limiting examples of suitable low molecular weight glycols and polyhydric alcohols include ethylene glycol, polyethylene glycol (eg, molecular weight 200-600 g / mol), butylene glycol, propylene glycol, polypropylene glycol (eg, molecular weight 425-2025 g / mol). , And mixtures thereof. A more detailed description of carrier components, including suitable hydrocarbons, polysiloxane compounds, and fatty alcohol ethoxylates, was published by Roe et al., July 1, 1997, "Topsheets with Lotions". It can be found in US Pat. No. 5,643,588, entitled "Diaper Having A Lotioned Topsheet".

【0047】

In one embodiment, the carrier comprises a combination of one or more petroleum-based hydrocarbons and one or more fatty alcohols as described above. When one or more petroleum hydrocarbons having about 4 to about 32 carbon atoms are used in combination with one or more fatty alcohols having about 12 to about 22 carbon atoms, the petroleum hydrocarbons have a lotion composition. It is contained in a total concentration in the range of about 20% to about 99% by weight, preferably about 30% to about 85% by weight, more preferably about 40% to about 80% by weight, and the fatty alcohol is a lotion. It is contained in a total concentration in the range of about 0.2% by weight to about 65% by weight, preferably about 1% by weight to about 50% by weight, more preferably about 2% by weight to about 40% by weight of the composition.

【0048】

C₄~ C₃₂Hydrocarbon, C₁₂~ C₂₂Petroleum-based carrier systems, including fatty alcohols and smoked silica, provide a homogeneous mixture of carriers, dermatological agents, and any optional ingredients, which uniform mixture provides sufficient contact between the skin and the dermatological agent. It is believed that this ensures effective prevention and treatment of skin diseases as a result. Smoked silica suitable for inclusion in a preferred petroleum-based carrier system or with any other carrier described herein includes colloidal exothermic silica pigments, which are cab-o-. Sold under the trade name of Cab-O-Sil®, which is Tuscola, Illinois. It is commercially available from Cabot Corporation, located in Illinois. These colloidal exothermic silica pigments are small granule exothermic silica pigments having an average particle size of about 0.1 micron to about 100 microns. Specific examples of commercially available Cab-O-Sil (registered trademark) silica pigments include Cab-O-Sil (registered trademark) TS-720 (polydimethylsiloxane treatment). Smoked Silica), Cab-O-Sil (Cab-O-Sil®) TS-530 (Trimethylsilaneted Smoked Silica), and Cab-O-Sil (Registered Trademark) )) TS-610 (dimethyldisilaneized smoked silica) can be mentioned. Smoked silica provides the lotion composition with the desired viscosity or thickening properties, typically from about 0.01% to about 15% by weight, preferably from about 0.1% to about 10% by weight, more preferably of the lotion composition. Is contained in a concentration in the range of about 1% by weight to about 5% by weight.

【0049】

Smoked silica can be used alone or talc, bentonite including treated bentonite, hectorite containing treated hectorite, calcium silicate containing treated calcium silicate, magnesium silicate. , Aluminum magnesium silicate, Zinc stearate, Sorbitol, Colloidal silicone dioxide, Whale wax, Carnauba wax, Bee wax, Candelilla wax, Paraffin wax, Microcrystalline wax, Castrol wax, Celesin, Espart, ouricuri, Reso wax (rezowax), polyethylene wax, C₁₂~ C₂₄It can also be used in combination with any other viscous or thickener, such as fatty acids, polyhydroxy fatty acid esters, polyhydroxy fatty acid amides, polymethacrylate polymers, polymethacrylate and styrene copolymers, or combinations thereof. is there. Any such other viscosity modifiers or thickeners are also included in total concentrations ranging from about 0.01% to about 15% by weight of the lotion composition. Another non-limiting example of a suitable viscous agent or thickener is bentonite, sold as Benton (Registered Trademark) 38, which is available from Rheox Incorporation. is there.

【0050】

It is preferable that the carrier is hydrophobic. Further, it is preferable that the lotion composition of the present invention does not contain a surfactant. Therefore, in a preferred embodiment of the present invention, the lotion has at least the same degree of hydrophobicity as the hydrophobicity of the top sheet, and the hydrophobicity of the lotion is mainly due to the lack of surfactant constituents. .. Polyoxyethylene alkyl ethers, alkyl ethoxylates, alkyl ethoxylates, which generally have a low degree of ethoxylation and an HLB value of less than about 7, if under some conditions the wettability of the hydrophobic carriers needs to be increased. Wetting agents such as amines, polyethylene glycol esters, and / or sorbitan fatty acid esters can also be optionally added. Suitable additives are miscible with carriers to form a homogeneous mixture. These wetting agents should also be relatively mild and non-irritating to the skin, as the skin sensitivities of people using the sanitary napkins of the invention may be high. Typically, these wetting agents are non-ionic not only because they are non-irritating to the skin, but also to avoid other unwanted effects on any underlying tissue laminate structure, such as loss of tensile strength. It is sex. Suitable wetting agents typically have an HLB value of less than 10, preferably less than 9, more preferably less than 8, and even more preferably less than 7.

【0051】

Non-limiting examples of suitable wetting agents include nonylphenol or polyoxyethylene nonylphenyl ether (ethoxylation 20; HLB5.7), octylphenol or polyoxyethylene octylphenyl ether (ethoxylation 10; HLB3.5), stearyl alcohol. Or polyoxyethylene stearyl ether (ethoxylated 20; HLB4.9), stearylamine or polyoxyethylene stearylamine (ethoxylated 20; HLB4.9), polyethylene glycol 200 dilaurate (HLB5.9), polyethylene glycol 200 distearate (HLB4) .8), sorbitan monostearate (Span 60 with HLB 4.7), sorbitan tristearate (Span 65 with HLB 2.1), sorbitan monooleate (HLB 4.3) Includes "Span 80") with sorbitan trioleate ("Span 85" with HLB 1.8), each of which is a Cell Chemical company. Available from Company (Incheon, South Korea) or Unichema (New Castle, Delaware, USA).

【0052】

The amount of wetting agent required to increase the wettability of the lotion composition to the desired degree depends on its HLB value and the degree of HLB of the carriers used and similar factors. Lotion compositions can contain from about 1 to about 50% wetting agent, if required to increase the wetting properties of the composition. Preferably, the lotion composition comprises from about 1 to about 25%, most preferably from about 10 to about 20% of wetting agent, when required to increase wettability.

【0053】

III. Absorbent Articles: The lotion compositions of the present invention preferably transfer from application of the composition on sanitary napkins to the skin. These products can also include a topsheet, a backsheet, and an absorbent core located between the topsheet and the backsheet, each component having a body contact surface or a wearer contact surface and a garment surface. .. The terms "body contact surface" and "wearer contact surface" are used interchangeably herein and, at some point during the period of use, contact between the wearer / user and the surface of the article. Refers to one or more faces of any article component intended to be worn or placed towards or adjacent to the wearer / user's body. As used herein, the term "clothing surface" means the outer or outer surface of any article component intended to be worn or placed adjacent to the wearer's underwear, or. In the case of absorbent articles that are not worn by the user, the garment surface is typically placed adjacent to the user's hands or other equipment that assists in the use of the absorbent articles. The terms "wearer" and "user" as used herein are not intended to be worn by the present invention, but rather absorb body exudates while moving the lotion composition of the present invention. It is used interchangeably when considering an absorbent article that may be intended to be used to.

【0054】

A. Topsheets: Absorbent articles can include any known or otherwise effective topsheets, such as those that are prone to subordination, have a soft feel, and are non-irritating to the wearer's skin. Is. Suitable topsheet materials are placed facing and in contact with the wearer's body and excrement quickly penetrates through it without fluid flowing back through the topsheet to the wearer's skin. Examples include liquid permeable materials that can be made. The topsheet allows the rapid movement of fluid through it, while allowing the lotion composition to move or migrate onto the outer or inner part of the wearer's skin. Suitable topsheets are various materials such as woven or non-woven materials; perforated film materials including perforated molded thermoplastic films, perforated plastic films, and fiber entangled perforated films; hydroformed heat. It can be produced by a plastic film; a porous foam; a reticulated foam; a reticulated thermoplastic film; a thermoplastic scrim; or a combination thereof.

【0055】

Perforated film materials suitable for use as topsheets are non-absorbent and permeable to body exudates, and have minimal or no backflow of fluid through the topsheet. Examples include perforated plastic films. Other non-limiting examples of other suitable molded films, including perforated and non-perforated molded films, are US Pat. No. 3,929,135 issued to Thompson on December 30, 1975; April 13, 1982. US Pat. No. 4,324,246 issued to Mullane et al.; US Pat. No. 4,324,314 issued to Radel et al. On August 3, 1982; to Ahr et al. On July 31, 1984. US Pat. No. 4,463,045 issued; US Pat. No. 5,006,394 issued to Baird on April 9, 1991; US Pat. No. 4,609,518 issued to Curro et al. On September 2, 1986. No.; and US Pat. No. 4,629,643, issued to Curro et al. On December 16, 1986, provide more details. The top sheet of the molded film on the market is the top sheet marketed by Procter &amp; Gamble Company (Cincinnati, Ohio) under the trade name DRI-WEAVE (registered trademark). Materials can be mentioned.

【0056】

Non-limiting examples of woven and non-woven materials suitable for use as topsheets include natural fibers, modified natural fibers, synthetic fibers, or fibrous materials made from combinations thereof. These fibrous materials can be either hydrophilic or hydrophobic, but the topsheet is preferably hydrophobic or hydrophobic. It is also an option that a portion of the topsheet can be made hydrophilic by using any known method of producing a topsheet containing hydrophilic constituents. One such method is for non-woven / perforated thermoplastic molded film topsheets with surfactants, as described in US Pat. No. 4,950,264 issued to Osborn on August 21, 1990. Treatment of perforated film constituents can be mentioned. Other suitable methods describing the process of treating topsheets with surfactants are disclosed in U.S. Pat. Nos. 4,988,344 and 4,988,345, both to Reising et al., January 29, 1991. Has been issued. The topsheet may include hydrophilic fibers, hydrophobic fibers, or a combination thereof.

【0057】

If the topsheet contains a non-woven fibrous material in the form of a non-woven web, the non-woven web can be manufactured by any known procedure for manufacturing a non-woven web, but as a non-limiting example of this, spunbonding, Carding, wet, winded, melt blown, needle punching, mechanical entanglement, thermomechanical entanglement, and wet entanglement. Specific examples of suitable melt blown processes are disclosed in US Pat. No. 3,978,185 issued to Buntin et al. On August 31, 1976.

【0058】

Other suitable non-woven materials include low-basis non-wovens, i.e. about 18 g / m.²~ About 25g / m²Examples thereof include non-woven fabrics having a basis weight of. An example of such a non-woven material is Veratec, a division of the International Paper Company located in Walpole, Massachusetts, under the trade name P-8. It is commercially available from Incorporation).

【0059】

B. Backsheet: The sanitary napkin of the present invention also includes a backsheet. The backsheet can be any known or otherwise effective backsheet material, provided that the backsheet is absorbed by the sanitary napkin and prevents the contained exudate from leaking out. Flexible materials suitable for use as backsheets include woven and non-woven materials, laminated tissues, polymer films such as polyethylene and / or polypropylene thermoplastics, composite materials such as film-coated non-woven materials, Alternatively, a combination thereof can be mentioned, but the present invention is not limited to these.

【0060】

C. Absorbent core: Sanitary napkins also contain absorbents. The absorbent core is typically placed between the topsheet and the backsheet. As used herein, the term "absorbent core" is a material suitable for absorbing, distributing, and storing aqueous fluids such as water found in urine, blood, menstrual blood, and body exudates. Or refers to a combination of materials. The size and shape of the absorbent core can be modified to meet the absorbent capacity requirements and to provide a sense of security to the wearer / user. Absorbent cores suitable for use in the present invention are used in the art of absorbent articles, provided that the liquid absorbent material can be configured or constructed to meet the absorption capacity requirements. It can be any known liquid absorbent material. Non-limiting examples of liquid absorbent materials suitable for use as absorbent cores include ground wood pulp, commonly referred to as air felt; crimped cellulosic lumps; superabsorbent polymers such as hydrogel-forming polymer gelling agents. Absorbable gel material to be; chemically stiffened, modified or crosslinked cellulose fibers; melt blown polymers including coforms; synthetic fibers including crimped polyester fibers; tissues including tissue wraps and tissue laminates; capillarys Channel fibers; absorbent foams; absorbent sponges; synthetic staple fibers; pulp moss; or any equivalent material; or combinations thereof.

【0061】

IV. Methods of Treating Skin: The present invention also relates to methods of treating skin with the lotion compositions described herein. Generally, a safe and effective amount of lotion composition is applied to the absorbent articles described herein, such a safe and effective amount is about 0.0015 mg / cm.²(0.01 mg / inch²) ~ About 100.5mg / cm²(100 mg / inch²), Preferably about 0.003 mg / cm²(0.02 mg / inch²) ~ Approximately 12.4mg / cm²(80 mg / inch²), More preferably about 0.02 mg / cm²(0.015 mg / inch²) ~ About 7.75mg / cm²(50 mg / inch²) Includes applying the lotion composition to an absorbent article.

【0062】

Typically at least about 0.00015 mg / cm²(0.001 mg / inch²) ~ About 15.5mg / cm²(100 mg / inch²), Preferably about 0.0006 mg / cm²(0.004 mg / inch²) ~ About 11mg / cm²(72 mg / inch²), More preferably about 0.005 mg / cm²(0.03 mg / inch²) ~ About 6.2mg / cm²(40 mg / inch²A safe and effective amount of the lotion composition of the invention is applied to the absorbent article so that the composition of) is typically transferred to the skin during each use of the absorbent article for about 3 hours. Will be done. Absorbent articles are generally replaced every 3-6 hours during the day and once for defense at night, resulting in at least a safe and effective amount of about 0.00045 mg / cm.²(0.003 mg / inch²) ~ Approximately 124mg / cm²(800mg / inch²), Preferably about 0.0018 mg / cm²(0.012 mg / inch²) ~ Approximately 88mg / cm²(576 mg / inch²), More preferably about 0.015 mg / cm²(0.09 mg / inch²) ~ About 49.6mg / cm²(320 mg / inch²) Lotion composition is administered at daily intervals (24-hour cycle). However, through the absorbent articles described herein, provided that a safe and effective amount of lotion composition is administered to provide the skin therapeutic effects described herein. The transfer of the lotion composition of the present invention onto the skin of the wearer can occur at appropriate intervals during the day, days, weeks, months, or years.

【0063】

The lotion compositions of the present invention can be applied to absorbent articles by any known or otherwise effective technique for distributing the lotion compositions onto absorbent products such as disposable absorbent articles. .. Non-limiting examples of methods of applying lotion compositions onto absorbent articles include spraying, printing (eg flexographic printing), coatings (eg contact slot coatings and gravure coatings), extrusions, or a combination of these application techniques. Can be mentioned. Application of the lotion composition onto an absorbent article facilitates the transfer or transfer of the lotion composition onto the skin for administration and / or adhesion of the lotion composition, resulting in a safe and effective amount of the composition. Will be applied for the improved prevention and reduction of skin diseases. Therefore, a safe and effective amount of lotion composition that will transfer or transfer to the skin is the type of lotion composition applied, the portion of the body contact surface to which the lotion composition is applied, and the lotion composition administered. It depends on factors such as the type of absorbent article used to do this.

【0064】

Any suitable method can be used in determining the amount of lotion composition described herein that is transferred to the wearer's skin during the use of an absorbent article containing the lotion composition. .. Specific examples of the method for calculating the transfer amount of the lotion composition include a gas chromatograph analysis procedure involving the analysis of in vivo skin-like substances and other quantitative analysis procedures. Suitable gas chromatograph procedures are described in more detail in the PCT International Publication Patent WO99 / 45973 by Donald C. Roe et al., Published September 16, 1999.

【0065】

V. Production Method: The lotion composition of the present invention shall be prepared by any known or otherwise effective technique to provide a lotion composition containing the essential dermatological agents defined herein. Is also possible. In general, lotion compositions are first prepared by making a carrier system containing suitable carriers such as petrolatum and behenyl alcohol in combination with a fumigated silica thickener. A mixture containing any optional ingredients, such as a skin therapeutic agent and any skin conditioning agent, is then added to the carrier system at a melting mixing temperature of about 80 ° C. Carrier systems, dermatological agents, and any optional ingredients are typically treated at temperatures of about 80 ° C, but these substances are about 60 ° C to about 90 ° C, preferably about 70 ° C to about 70 ° C. It can be processed at temperatures in the 90 ° C range. The resulting lotion composition is subsequently applied to the topsheet constituents of the absorbent article using a contact coater such as Nordsen EP11-12-02.

【0066】

The lotion composition of the present invention is prepared so that the composition can be applied to the absorbent article so that a safe and effective amount of the composition is transferred onto the wearer's skin of the absorbent article as a result. .. As such, the lotion composition is relatively immobile under ambient conditions, and is localized on the wearer's contact surface of the absorbent article and can be easily moved to the wearer at body temperature, and under more extreme storage conditions. It is preferable to have a product concentration that is not completely liquid. In other words, the lotion composition is such that the composition is easily moved onto the skin by normal contact, wearer movements, and / or body heat, ambient conditions (about 25 ° C) and / or body temperature. Solid or semi-solid at (about 37 ° C). The softness of the lotion composition can be measured by the ASTM D5 test method with the use of a permeability meter to measure the softness. Typically, the lotion compositions of the present invention are about 10 to about 300, preferably about 20 to about 250, more preferably, when measured at 40 ° C. by the test procedure outlined in the ASTM D5 test method. Has a softness of about 30 to about 200.

【0067】

The solid or semi-solid softness of this lotion composition allows the concentration of the composition to be applied to the absorbent article to be relatively low in order to achieve the desired lotion effect. A "semi-solid" is a rheological composition such that the composition remains relatively stationary at a desired position on the absorbent article and does not tend to flow or migrate to an undesired position on the article. It means having a rheology typical of a body or plastic fluid. The solid lotion compositions of the present invention can also remain in special positions and do not flow or migrate to undesired positions in the article. These solid and semi-solid lotion compositions are high enough to keep the composition localized in the intended position of the article, but not high enough to prevent the wearer from moving to the skin. Has. Typically, the final product of solid and semi-solid lotion compositions is about 3 x 10 at 40 ° C.³Dyne / cm²Under shear stress conditions (shear stress applied to the composition while the absorbent article is stored or transported at a temperature of about 40 ° C), about 1.0 × 10⁶Centipores ~ about 1.0 × 10¹⁰It has a viscosity in the range of centipores.

【0068】

However, solid and semi-solid lotion compositions can be made fluid so that they can be transferred or transferred onto the skin by applying shear stresses that result in deformation of the composition. The shear stress applied at least once during the wearing of absorbent articles under temperature conditions of about 40 ° C is typically about 1.0 × 10.⁶Dyne / cm²And due to this shear stress the lotion composition is about 1.0 × 10¹Centipores ~ about 1.0 × 10⁵It can result in having a viscosity of centipores. It is believed that under the applied shear stress, the lotion composition obtains lower viscosity values due to the fact that while the composition contains solid constituents, the composition also contains liquid material. .. Sufficient lubrication between the wearer's skin and the body contact surface of the article so that the lotion composition is effectively transferred onto the wearer's skin as a result during wearing of the absorbent articles described herein. It is desirable to achieve low viscosity in order to obtain. Viscosities at various shear stresses are measured using rheometers known in the art, such as the Rheometer SR-2000 available from Rheometrics Incorporation. be able to.

【0069】

The lotion composition is typically applied to the topsheet of an absorbent article for delivery of the lotion composition onto the outer or inner surface of the skin. The lotion composition can also be applied to other areas of the absorbent article, in these areas the wings, side panels, absorbent core, any secondary layer between the core and the topsheet, or absorbent. Any other area of the article may be mentioned.

【0070】

Methods of assembling absorbent articles, such as the disposable absorbent articles described herein, include prior art known in the art for constructing and constructing disposable absorbent articles. For example, is the backsheet and / or topsheet bonded to the absorbent core by a uniform continuous layer of adhesive, a patterned layer of adhesive, or a separate array of lines, spirals, or dots of adhesive? , Or can be combined with each other. The perfect adhesive is manufactured by the HB Fuller Company in St. Paul, Minnesota under the designation HL-1258 or H-2031.

【0071】

The lotion compositions of the present invention also make compositions known as aerosol dispensers, trigger spray dispensers, pump spray dispensers, bottles, stick dispensers, cotton balls, patches, sponges, and any other type, or It can be delivered on the skin by incorporating it into other effective delivery media.

[Example]

【0072】

The following examples further describe and articulate embodiments within the scope of the invention. The examples are given solely for illustrative purposes and should not be construed as limiting the invention as many of those modifications are possible without departing from the spirit and scope of the invention. All illustrated concentrations are weight-percentage, unless otherwise stated.

【0073】

(Example I) The compositions exemplified in Table 1 below are typical examples of the carrier system of the lotion composition of the present invention. Carrier systems are generally prepared by combining petrolatum by weight with fatty alcohols such as behenyl alcohols and then heating the mixture to about 80 ° C. with stirring using a slow propeller mixer. A viscous agent or thickener is then added to the mixture and the components are shear mixed into the final carrier system. Suitable thickeners or thickeners include Behenes-10, fumigated silica, bentonite, and steares-2, and the thickeners or thickeners are used alone or in combination. Ingredients can be shear mixed at 11,000 rpm (rpm) using an IKA Ultra Turrax Shear Mixer.

【0074】

Alternatively, petrolatum, fatty alcohols, and thickeners or thickeners are combined and heated to 80 ° C with stirring to melt the ingredients, and then of Tokusyu Kika TK Robo Mics operating at 5,000 rpm. Can be mixed into the final carrier system using such a high speed blade mixer.

【0075】

[table 1]<img file="JP2005504591A_D0003.tif" />%-Weight% 1-Vaseline, available as Protopet (R) 1S from Witco Corporation 2-Behenyl Alcohol, Lanette from Cognis Corporation Available as Lanette 22 3-Cetearyl Alcohol, available as Stenol 1822 from Cognis Corporation 4-Behenes-10, Margintal from Cognis Corporation (Mergital®) Available as B10 5-Smoked Silica, Available as Cabot Corporation TS-720 6-Bentnite, Leox Inco-Po Available as Bentone (R) 38 from Rheox Incorporation 7-Staires-2, Uniqema Available from Corporation as Brij (registered trademark) 762 [0076]

(Examples II to IX) The following Examples II to IX described in Table 2 below are representative examples of lotion compositions of the present invention containing the carrier system identified in Table 1. Lotion compositions are formulated with a premix solution of zinc oxide skin remedies and by adding zinc oxide premixes to other skin remedies and any of the ingredients such as panthenol and glycerin, or hexamidine. And niacinamide prepared by blending a skin lotion of a skin lotion and any of the components. The skin treatment solution is then added to a carrier system such as that listed in Table 1, and the skin treatment solution and carrier system are heated to a temperature of about 80 ° C with stirring. All ingredients are included based on the weight of the lotion composition. These lotion compositions are particularly effective in controlling skin diseases such as skin erythema, malodor, and skin bacterial infections.

【0077】

[Table 2]<img file="JP2005504591A_D0004.tif" />8-Zinc Oxide Premix, ULTRAFINE 350 available from Kobo Incorporation Zinc Oxide, Arlecel P100, available from Uniqema Incorporation , And 9-hexamidin containing 70% zinc oxide mixture of Salacos (registered trademark) 99, available from Ikeda Incorporation, Laboratories celloloby as hexamidine diisethionate. Available from Laboratories Serolobilogiques under the trade name ELASTABHP100 10-Pantenol, Roche Vitamins Incorporation Available as D-Pantenol 11-Glycerin, Procter &amp; Gamble Glycerin, USP Kosher (USP) from Procter &amp; Gamble Company Available as Kosher®) 12-Niacinamide, available from Em Industries HHN 13-Acidized niacinamide, produced by reaction of niacinamide with stearic acid 14-Camomir, Dragoco ) Available as Phytoconcentrol chamomile [0078]

The lotion composition of Example II was subsequently produced by the Procter &amp; Gamble Company for sanitary napkin products such as Always Wing Regular Long. DRI-WEAVE Applies to the entire wearer contact surface of the topsheet. Approximately 0.4 mg / cm to deliver a safe and effective amount of lotion composition on the skin²(2.6 mg / inch²) Lotion composition is applied to the topsheet using a Meltex EP45 hot melt applicator with a head operating temperature of about 90 ° C.

【0079】

The lotion composition of Example III is subsequently manufactured by the Procter &amp; Gamble Company for a sanitary napkin product such as Envive Miniform, DRI. -WEAVE) Applied by spraying the composition over the entire wearer contact surface of the topsheet. Approximately 4.0 mg / cm to deliver a safe and effective amount of lotion composition on the skin²(25.8 mg / inch²) Lotion composition is applied to the topsheet using a hot melt pneumatic Dynatec E84B1758 spray head with a head operating temperature of about 90 ° C and a spray pressure of about 16 kilopascals (KPa).

【0080】

The lotion composition of Example IV was subsequently applied to the wearer contact surface of a hydrophobic spunbonded bicomponent polyethylene / polypropylene topsheet (BBA, Washougal, WA) of a sanitary napkin product. It is applied by slot coating the striped pattern arrangement (Nordsen EP11-12-02). In order to deliver a safe and effective amount of lotion composition on the skin, the lotion composition is applied to a striped pattern arrangement on the topsheet, each of which is 40 mm (mm) wide x 200 mm. Includes at least two stripes of length, and applied on it approximately 0.8 mg / cm²(5.2 mg / inch²) Has the composition.

【0081】

The lotion composition of Example V is subsequently produced by the Procter &amp; Gamble Company and is a dry weave (DRI-) of panty liner products such as Alldays Regular. WEAVE) Applied by spraying a striped arrangement of the composition onto the wearer contact surface of the topsheet. In order to deliver a safe and effective amount of lotion composition on the skin, the lotion composition is applied in a striped arrangement on the topsheet, each of which is 40 mm (mm) wide × Includes at least two stripes that are 200 mm long, as well as applied on it approximately 0.6 mg / cm²(3.9 mg / inch²) Has the composition. The lotion composition is applied to the topsheet using a hot melt pneumatic Dynatec E84B1758 spray head with a head operating temperature of about 90 ° C and a spray pressure of about 16 kilopascals (KPa).

【0082】

The lotion composition of Example VI is subsequently manufactured by the Procter &amp; Gamble Company and is a dry weave (DRI-) of panty liner products such as Alldays Regular. WEAVE) Applies to the entire wearer contact surface of the topsheet. Approximately 0.2 mg / cm to deliver a safe and effective amount of lotion composition on the skin²(1.3 mg / inch²) Lotion composition is applied to the topsheet using a Meltex EP45 hot melt applicator with a head operating temperature of about 90 ° C.

【0083】

The lotion composition of Example VII was subsequently produced by the Procter &amp; Gamble Company for a sanitary napkin product such as Envive Miniform, DRI. -WEAVE) Apply by spraying the composition over the entire wearer contact surface of the topsheet. Approximately 1.0 mg / cm to deliver a safe and effective amount of lotion composition on the skin²(6.5 mg / inch²) Lotion composition is applied to the topsheet using a hot melt pneumatic Dynatec E84B1758 spray head with a head operating temperature of about 90 ° C and a spray pressure of about 16 kilopascals (KPa).

【0084】

The lotion composition of Example VIII is subsequently produced by the Procter &amp; Gamble Company and is a dry weave (DRI-) of panty liner products such as Alldays Regular. WEAVE) Applies to the entire wearer contact surface of the top sheet. Approximately 0.4 mg / cm to deliver a safe and effective amount of lotion composition on the skin²(2.6 mg / inch²) Lotion composition is applied to the topsheet using a Meltex EP45 hot melt applicator with a head operating temperature of about 90 ° C.

【0085】

The lotion composition of Example IX subsequently slots a striped arrangement of the composition on the wearer contact surface of a hydrophobic spunbond bicomponent polyethylene / polypropylene topsheet (BBA, Washogal, WA) of a sanitary napkin product. It is applied by coating (Nordsen EP11-12-02). Approximately 3.0 mg / cm to deliver a safe and effective amount of lotion composition on the skin²(19.5 mg / inch²) Lotion composition is applied to the top sheet.

【0086】

For sanitary napkins, the amount of lotion added can be significantly higher than that used for other absorbent articles such as diapers. Although not bound by theory, for example, lotions are 3 mg / cm.², 4mg / cm², 5mg / cm², 6mg / cm², 7mg / cm², 8mg / cm², 9mg / cm², Or 10 mg / cm²It is believed that it can be added at the level of. These levels refer to the area actually covered by the lotion.

【0087】

All references cited are incorporated herein by reference in their relevant parts, and any citation of any document should not be construed as an acceptance that it is prior art in the context of the present invention.

[Simple explanation of drawings]

【0088】

FIG. 1 is a perspective view of a sanitary napkin having a topsheet and lotion composition.