Nasal washing pharmaceutical composition and nasal washing device using the composition

This application is a partial continuation of US Patent Application No. 10 / 69,595 dated June 4, 2002.

The present invention relates to a drug composition to be administered to the nasal cavity and a nasal irrigation device for that purpose.

Nasal irrigation alleviates and reduces problems such as allergies, infections, and post-surgery disorders. This is because cleaning flushes out allergens (allergens), microorganisms (viruses, bacteria), by-products of the human body (pus, mucus), dust, and soot-like substances. Inflammatory swelling is reduced and the scab after nasal surgery is also relieved, which accelerates the healing process. Nasal irrigation with saline solution is a known method and has been recommended by physicians for at least 100 years.

<p> A known nasal irrigation device on the market is a potter container for multiple use, but this container is expensive and comes pre-loaded with a porcelain outlet and saline and water taken from the Atlantic Ocean, respectively. It has two disposable variable parts packed together, which, of course, is very expensive for normal use, the outlet does not work well and therefore cannot fill the nasal cavity, Also, only pre-filled saline solution can be used in the nasal irrigation device.</p><p> A primary object of the present invention is to provide an outlet portion of a nasal irrigation device that is quick and comfortable to use and has a good function of filling the nasal cavity with a liquid.</p><p> A second object of the present invention is to provide an inexpensive, simple and well-functioning nasal irrigation device for multiple use.</p>

<p> A primary purpose is to provide an outlet for a nasal irrigation device that is located between the outlet end, the connecting end, and between these ends and has a nozzle-type channel with a squeezed portion and an enlarged outlet. Achieved by the part. This outlet is the mucous membrane in the nasal cavity where the liquid pumped through the channel is turbulently released from the channel, causing the liquid to fill the nasal cavity quickly and at the same time to cause the discomfort of fine jet sulfur. Prevent direct spraying on.</p><p> The outlet portion preferably has a circumferentially increasing portion, such as a water droplet or balloon-shaped portion, at the outlet end, whereby the outlet portion seals the edge of the nostril regardless of the size of the nostril. This has the advantage that the liquid does not leak out in the opposite direction and that the shape of the outlet helps to open the nostril arch, which is the narrowest part of the nostril.</p><p> The outlet portion is preferably made of a flexible material, such as silicone rubber, that is soft and comfortable to the nose.</p><p> The shape of the channel at the connecting end of the outlet should be suitable for the connecting means of the nasal irrigation device, for example, a conical shape with the largest diameter at the end, whereby the exit is conical at the tip. Will be fitted with a syringe having.</p><p> A second object is a nasal irrigation device comprising an outlet portion according to the present invention and a syringe or compressible balloon for cleaning fluid, whereby the outlet portion is provided at the outlet opening of the syringe or balloon provided with the connecting means. Achieved by. Nasal irrigation devices for either of the two types are simple, inexpensive to manufacture, and easy to use, especially when the syringe is deformed, it is easy to aspirate the cleaning solution into the syringe before cleaning the nostrils. And, in particular, the deformation of the syringe makes it easy to keep the syringe clean.</p><p> Of course, the outlet may be connected to any other form of nasal irrigation device.</p><p> The cleaning solution can be, for example, a saline solution, an oil emulsion, or a saline solution containing a drug. More specifically, the aromatic composition according to the invention is for administration to the nostrils and is a saline carrier mixed with sesame oil and volatile oils such as peppermint oil and / or eucalyptus oil. .. Before injecting this composition, it is inhaled into a syringe and the outlet is fitted to close the nostrils.</p>

Here, the present invention will be described with reference to the accompanying drawings by way of exemplary embodiments.

FIG. 1 shows an outlet portion 1, which includes an outlet end 2 and a connecting end 3. Channel 4 is placed between these ends 2 and 3. Channel 4 is nozzle-shaped and shows a throttle portion 5 and an enlarged outlet portion 6 in the cross section. At the connection end 3, the channel 4 has a shape adapted to the connection type of the nasal irrigation device in which the connection end is arranged. As shown, channel 4 has a conical shape with a larger diameter connecting end to fit the end of a syringe with a conical tapered end, such as a monoject syringe. Eggplant.

The exit portion 1 has an outer shape reminiscent of a lolly stick. That is, the connection end 3 is a stick, and the outlet end 2 is a candy attached to the tip of the stick. The outlet end 2 has a portion 12 that expands in the circumferential direction, and this portion is preferably balloon-shaped or water-drop-shaped. That is, the outer diameter of the outlet portion increases by a predetermined distance from the outlet end portion 2 inward, and then the outer diameter decreases. This allows the exit portion 1 to be introduced into the nostril over a short distance, while at the same time the increased outer diameter completely closes the opening of the nostril with the exit portion 1, thereby connecting the outlet portion 1 and the nostril. The space will be sealed. Such a design also results in the exit portion 1 fitting to any different size of nostril. It is desirable that the outlet portion 1 is made of silicone rubber.

When the nostril cleaning liquid is pumped into the outlet portion 1, for example, from the syringe to the channel 4, the pressure increases when the liquid passes through the squeezing portion 5, and then the speed of the liquid when reaching the enlarged outlet increases. , Which causes the flow to become turbulent.

FIG. 2 shows the nostril cleaning device 7 according to the first embodiment of the present invention. The instrument comprises an outlet portion 1 provided at the tip 8 of the syringe 9, and as shown, the syringe has a conical tip 8.

FIG. 2 shows a nostril cleaning device according to a second embodiment of the present invention. This device includes an outlet portion 1 provided at the hollow tip portion 10 of the balloon-shaped main body 11. The balloon-shaped main body 11 has compressibility so that the liquid contained therein can be pushed out from the outlet portion through the hollow tip portion 10.

When using the outlet portion, a warm cleaning solution is drawn into the syringe 9 or balloon 11 by negative pressure, whereby the cleaning solution is pushed out through the outlet portion 1 and further introduced into the user's nostrils.

Referring to FIG. 4, the silicone outlet portion 20 according to the third embodiment of the present invention has a hollow connecting end 22 and an enlarged balloon-shaped outer end 24. The outer end 24 has a defined channel 26 therein, which extends from the end 28 of the connecting end 22 to the outer tip 30 of the outer end 24. The channel 26 preferably has a straight tubular inner wall, whereby the channel 26 has either a constant inner diameter or an inner diameter that decreases or increases at a constant rate. Of course, the channel 26 may have a variable diameter if necessary. The channel 26 extends from the tip 30 to the end 28, so that the tip 30 communicates fluidly with the interior of the hollow connecting end. As mentioned above, the outer end 20 can be connected to a suitable syringe device such as the syringe 9 shown in FIG. 2, thereby injecting the appropriate drug into one of the user's nostrils. it can. Once the drug is drawn into the syringe 9, the silicone portion 20 is sealed inside the nostril or against the bottom of the nose and the solution contained in the drug is injected from the syringe. Part 20 should suck up some air, which causes the injected liquid to become turbulent, not just a straight stream.

Suitable pharmaceutical compositions in the present invention include many basic ingredients for nasal administration. The composition comprises a number of selected, active aromatic substances that are therapeutically effective. Suitable ingredients include salt, sesame oil and volatile oils such as peppermint oil or eucalyptus oil. These compositions may be dissolved in water or other suitable liquid. More specifically, the drug composition comprises finely ground salt, such as sodium chloride (NaCl) or any other suitable salt, with a liquid, such as water, which serves as a saline carrier that meets the pharmaceutically acceptable conditions. Function. Saline carriers are physiologically compatible with the human body. This compatibility is important for user comfort and to avoid damage to the nasal mucosa or mucosa within the nostrils. Saline carriers can range from 0.1 to about 99.4% by weight. The salt content in the solution is about 0.5% to about 1.9%. More preferably, the amount of salt is 0.8% to 1.0%, most preferably about 0.9% by weight, which is very close to the salt concentration of the human body.

The first basic component in the present invention is sesame oil or any other lubricating oil substance. Sesame oil can be cold squeezed oil, which contains vitamin E, known as an antioxidant. Antioxidants can be used to eliminate unwanted substances produced in the body. Antioxidants are free radicals O that can be present in the body₂It becomes useful for neutralizing harmful molecules in the body, thereby neutralizing oxygen. Sesame oil also contains large amounts of triglycerides such as linoleic acid, which are naturally present in the outer part of the cells of the mucosa. Sesame oil can also be used to lubricate the mucous membranes and prevent unwanted drying of the mucous membranes. Washing the nose with a completely conventional salt solution tends to dry the mucous membranes. The first sesame oil component is about 0.02% to about 0.10%, preferably about 0.03% to 0.07%, most preferably 0.05% by weight. If the amount of the first component added is too large, it will be difficult to dissolve the first component in water. If an insufficient amount of the first ingredient is used, the bactericidal and anti-inflammatory effects of the first ingredient will be lost.

The second component in the present invention comprises an aromatic bactericidal component, which has a cleaning effect and an effect of preventing the excessive growth or development of harmful bacteria. The second component is to reduce the anti-inflammatory and swelling of dry mucous membranes. This ingredient is an essentially volatile oil, such as peppermint oil and / or eucalyptus oil. The second component is contained in the composition from 0.003% to about 0.040%. More specifically, when the second component is peppermint, this component contains about 0.005% to 0.040%, preferably about 0.012% to 0.020%, most preferably about 0.016% by weight. When the second component is eucalyptus oil, this component is contained from about 0.003% to 0.020%, preferably about 0.006% to 0.010%, most preferably 0.008% by weight. If the amount of the second ingredient used is excessive, the user will find the solution to be very irritating.

The compositions according to the invention can be provided in powder form, tablets or any other suitable form. The examples shown below illustrate further embodiments within the scope of the present invention. These examples are given individually to illustrate the examples, but should not be construed as limiting the invention, and many variants are provided without departing from the spirit and scope of the invention. It is possible.

The following ingredients were mixed to prepare a drug composition for the nasal cavity. Ingredients Weight% Sodium chloride 0.90% Sesame oil 0.05% Eucalyptus oil 0.008% Water 100.00%

Tablets or an appropriate amount of particulate matter was added to a glass of water to make it soluble in water. Appropriate amounts of mixing were made as appropriate to ensure that the composition was well soluble in water. The dissolved composition is injected into the nostrils with a nasal irrigation device.

The following ingredients were mixed to prepare a drug composition for the nasal cavity. Ingredients Weight% Sodium Chloride 0.9% Sesame oil 0.05% Peppermint oil 0.016% Water 100.0%

This composition is dissolved in water prior to injecting the dissolved composition into the nostrils with a nasal irrigation device.

Although the present invention has been described by suitable composition and embodiments, it should be appreciated that some substitutions and exchanges are possible without departing from the spirit and scope of the following claims.

<figref num="1">It is a figure which shows one Embodiment of the outlet part of the nasal cavity cleaning device by this invention.</figref><figref num="2">It is a figure which shows the syringe type nasal cavity cleaning apparatus which concerns on 1st Embodiment of this invention.</figref><figref num="3">It is a figure which shows the balloon-shaped nasal cavity cleaning apparatus which concerns on the 2nd Embodiment of this invention.</figref><figref num="4">It is a figure which shows the nasal cavity cleaning apparatus which concerns on the 3rd Embodiment of this invention.</figref>

Code description

1,20 Outlet part 2 Outlet end 3,22 Connection end 4,26 Channel 5 Aperture part 6 Outlet part 8 Syringe 9 tip 9 Syringe 10 Hollow tip of instrument body 11 11 Instrument body (balloon) 24 Outer end Part 28 End of connection 22 22 30 Tip of outer end 24