Wild silkworm silk fiber

Description: TECHNICAL FIELD [Detailed description of the invention]

【0001】

[Technical field to which the invention belongs]

The present invention relates to an application to a cosmetic composition containing silk fibers produced by wild silkworms and one or more of a whitening agent, an antioxidant, an antibacterial agent, and a moisturizing agent.

【0002】

[Conventional technology]

The application of silk moth silk fiber to cosmetics has been practiced for a long time. For example, the silk moth silk fiber itself is applied to soap (Tokukosho 25-3733), and the silk moth silk fiber is processed into a solution or powder. Applied to cosmetics in (Japanese Patent Laid-Open No. 26-4947) (Japanese Silk Moth 27-299) (Japanese Silk Moth 40-24920) (Japanese Patent Laid-Open No. 54-138131) (Japanese Patent Laid-Open No. 55-27120) (Japanese Patent Laid-Open No. 55-66929) ) (Japanese Patent Laid-Open No. 57-4909) (Japanese Patent Laid-Open No. 57-4910) (Japanese Patent Laid-Open No. 57-3827) (Japanese Patent Laid-Open No. 58-15905) (Japanese Patent Laid-Open No. 60-4114) (Japanese Patent Laid-Open No. 59-65008) ( Japanese Patent Application Laid-Open No. 62-36308) is known.

【0003】

However, these use silk fibers produced by the silk moth "Bombyx mori Linne" (Silkworm family), and these silk fibers are called "raw silk" before scouring, and their composition is called "fibroin". It is made up of a protein that is the main component of fiber and a protein that surrounds fibroin called "sericin". Generally, fibroin protein is called silk fiber, and it is crushed into fine powder or hydrolyzed to make a solution and applied to cosmetics. On the other hand, sericin protein is removed at the stage of refining raw yarn, but recently it has been purified and applied to cosmetics. Fibroin protein fine powder is known to be applied as a functional material for cosmetics, as a feel improver for foundations, and as a moisturizer that makes use of hygroscopicity or moisture release as a protein, but other functionality is currently present. , Not reported.

【0004】

On the other hand, as for wild silk moths, various kinds of silk moths are known, for example, Saku silk moth "Antheraea pernyi", Eri silk moth "Samia cynthia ricini", Tasar silk moth "Anthraea mylitta", Anafé "Anaphe reteculata", Muga silk moth " "Antheraea assama", Cricula "Cricula trifenestrata", silk moth "Antheraea yamamai" and the like can be mentioned.

【0005】

The silk fibers produced from the silk moth have a dense structure, but when the silk fibers produced from the silk moth were observed with a scanning electron microscope, no pores were observed in the cross section, and the silk fibers were produced from the above-mentioned wild silk moth. Very small pores are found in silk fibers, and the application of ultraviolet (UV) cut natural materials that take advantage of this structural feature is known (Japanese Patent Laid-Open No. 11-181399).

【0006】

[Problems to be Solved by the Invention]

Therefore, the present inventors have focused on the pore property, which is a characteristic of silk fibers produced from wild silkworms, and further studied the application to effective cosmetics in combination with various functional ingredients. It was.

【0007】

[Means for solving problems]

In view of these circumstances, the present inventors are extremely excellent in cosmetic compositions containing silk fibers produced from wild silkworms and one or more of whitening agents, antioxidants, antibacterial agents, and moisturizers. They have found that they have a whitening effect, an antioxidant effect, an antibacterial effect, and a moisturizing effect, and have completed the present invention.

【0008】

BEST MODE FOR CARRYING OUT THE INVENTION

The "silk fibers produced from wild silk moths" used in the present invention include the silk moth "Antheraea pernyi", the silk moth "Samia cynthia ricini", the tasar silk moth "Anthraea mylitta", the silk moth "Anaphe reteculata", and the silk moth "Anaphe reteculata". Silk fibers (cocoon or cocoon thread) produced from "Antheraea assama", "Cricula trifenestrata", silk moth "Antheraea yamamai" and the like can be used.

【0009】

The particle size of the "silk fiber produced from wild silkworms" used in the present invention is not particularly limited, but a silk finely divided into fine particles of usually 0.01 to 500 μm, preferably 0.1 to 50 μm can be used. The fibers can also be washed and colored before use. The means for atomizing is not particularly limited, and examples thereof include means for physically pulverizing.

【0010】

The "whitening agent" used in the present invention includes benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5). -Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-Dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivatives (para-aminobenzoic acid, ethyl para-aminobenzoate, glyceryl para-aminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamic acid derivatives (Ethyl paramethoxycinnamic acid, isopropyl paramethoxycinnamic acid, octyl paramethoxycinnamic acid, 2-ethoxyethyl paramethoxycinnamic acid, sodium paramethoxycinnamic acid, potassium paramethoxycinnamic acid, mono-2-ethyl glyceryl hexate of diparamethoxy cinnamic acid, etc.), salicylate derivatives (Octyl salicylate, phenyl salicylate, homomentyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranic acid derivative (methyl anthranylate, etc.), urocannic acid derivative (urocanic acid, ethyl urocanate, etc.), Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivatives (hydroquinone benzyl ether, etc.), coumarin or its derivatives, amino acid compounds, benzotriazole or its derivatives, tetrazol or its derivatives , Imidazoline or its derivatives, pyrimidine or its derivatives, dioxane or its derivatives, camphor or its derivatives, furan or its derivatives, pyron or its derivatives, nucleic acids or its derivatives, allantin or its derivatives, nicotinamic acid or its derivatives, vitamin B6 or Derivatives thereof, Vitamin E or its derivatives, Kodiic acid or its derivatives, Umberiferone, Esculin, benzyl cinnamic acid, Synoxate, Oxybenzon, Dioxybenzon, Octabenzon, Slysobenzoic acid, Benresorcinol, Arbutin, Guiazulene, Sikonin, Bicarin, Bicarein, Belverin, neoheliopan, escalol, zinc oxide, zinc peroxide, talc, cinnamic acid, placenta extract (human, cow, pig, horse), N-acetyltyrosine or soDerivatives, glutathione, hydrogen peroxide, silk extract, ellagic acid, lucinol, plant extract (Asenyaku, sweet tea, artea, aloe, aloe vera, ginkgo, agetsu, prolongation grass, artemisia montana, younger brother cut grass, odorikosou, kudzu root, chamomile, mulberry Or Yamagwa, licorice, bellflower, kina, kihada, clara, mulberry, mountain sardine, katsura, geranium thunbergii, quintuplet, tea, saiko, salvia, mountain sardine, sardine, sardine, birch, watermelon, sardine, sequel, Soybeans, Cloves, Toki, Mamedaoshi, Dokudami, Shishiudo or Udo, Hakunanten or Akananten, Hatomugi, Hamago or Mitsuba Hamago, Hamamelis, Hama windbreak, Hops, Red flowers, Peony, Mao, Matsuhodo, Mannenrou, Melissa, Hiougi, Yukinoshita Eucalyptus, yomogi or artemisia montana, green tea, mulberry, brown algae, red algae, green algae) and the like can be used, and one or more species selected from these can also be used in combination.

【0011】

The "antioxidant" used in the present invention includes SOD (super oxide dismutase), catalase, glutathione peroxidase, vitamin C or a derivative thereof (vitamin C phosphate magnesium salt). , Vitamin C glucoside, etc.), stearic acid ester, vitamin E or a derivative thereof, nordihydroguaseletic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosole, parahydroxyanisole, propyl gallate, Sesamol, sesamolin, gosipole, propolis, β-carotene, plant extracts (sweet tea, ginkgo, ages, prolongation grass, younger cut grass, sesame, salvia, birch, cloves, white south heaven or red south heaven, hamamelis, mannenrou, melissa, green tea), etc. It can be used, and one or more selected from these can be used in combination.

【0012】

The "antibacterial agent" used in the present invention includes acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, hypochlorite. Sodium, chloramine T, salashi powder, iodine compound, iodoform, sorbic acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenoic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, Phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, timol, phenethyl alcohol, O-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, Isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zincpyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl) Phenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, potassium lauroyl sarcosin, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, etc.) , Methyl Rosaniline Chloride), Formaldehyde, Hexamine, Brilliant Green, Malakite Green, Crystal Violet, German, Photoreceptor No. 101, Photoreceptor No. 201, Photoreceptor No. 401, N-Long Chain Acylbasic Amino Acid Derivatives and Acid Additive Salts, Zinc oxide, hinokithiol, clara extract, propolis and the like can be used, and one or more selected from these can be used in combination.

【0013】

The "moisturizer" used in the present invention includes glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidone carboxylic acid or its salt , Sodium lactate, urea, sorbitol, trehalose, amino acids or derivatives thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxy Proline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids), fats and oils "Avocado oil, almond oil, uikyo oil, Egoma oil, olive oil, orange oil, orange raffer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef fat fatty acid, quince seed oil, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, Camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, sunflower oil, sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, palm oil, Eucalyptus oil, beef fat, pork fat, squalane, squalane, pristan or hydrogenated additives of these fats and oils (hardened oil) ", waxes (mitsurou, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, Montan wax, cellac wax, rice wax), mineral oil (liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystan wax), natto fungus metabolite, natto extract, silk fiber extract, plant extract (red pine or red pine sap, aloe) , Aloe vera, kudzu root, chamomile, licorice, cucumber, rice or rice bran, shiitake mushroom, birch or birch sap, assembly, mulberry, Himematsutake, bib leaf, hechima, peony, purple, yomogiCan be used, such as Artemisia montana, and one or more selected from these can be used in combination.

【0014】

As the "whitening agent", "antioxidant", "antibacterial agent", and "moisturizing agent" used in the present invention, various commercially available ingredients may be used, and the plant extract is not particularly specified. , Various parts of each plant (whole plant, flower, flower head, flower ear, female flower ear, fruit ear, fruit, bud, peel, glandular body, stem, leaf, branch, branch leaf, trunk, bark, rhizome, tuber, root Bark, roots, tuberous roots, seeds, umbrellas or stalks, offspring, mycelia, mycelia, etc.) are squeezed as they are or after crushing. Alternatively, it may be extracted as it is or after pulverization with a solvent, and the extraction solvent may be selected in consideration of the purpose of use, the type of the product to be provided, the processing treatment to be performed later, etc., but usually, water is used. Lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin, or hydrous polyhydric alcohols, acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more selected from the various organic solvents of. However, if the content of the organic solvent is not preferable due to the purpose of use, only water may be used, or ethanol or the like which is easily removed after extraction may be used and used alone or in an arbitrary mixed solution with water. Alternatively, it may be exploited and extracted. Furthermore, it can be used in a state where each solvent extract is combined. Further, in addition to hydrolysis extraction of various plant extracts by enzymatic decomposition, those obtained by hydrolysis with acid / alkali can also be used.

【0015】

The "silk fiber produced from wild silkworms" of the present invention can be contained in the cosmetic composition as it is, but the content thereof is not particularly specified, and the type, quality and expectation of the dosage form for the cosmetic composition. It varies slightly depending on the degree of action to be applied, and is usually 0.001% by mass or more (hereinafter, expressed as%), preferably 0.01 to 20%. In the case of a bathing agent, the prescription may be considered so that the concentration is about the same by pouring it into 200 to 300 L of bath water.

【0016】

Similarly, each of the "whitening agent", "antioxidant", "antibacterial agent", and "moisturizer" of the present invention can be contained in the cosmetic composition, and the content thereof is not particularly specified. It varies slightly depending on the type, quality, and degree of expected action of the composition, and is usually 0.001% or more, preferably 0.1 to 20%. In the case of a bathing agent, the prescription may be considered so that the concentration is about the same by pouring it into 200 to 300 L of bath water.

【0017】

The method of adding the silk fiber produced by the wild silkworm of the present invention to a cosmetic composition containing any one or more of a whitening agent, an antioxidant, an antibacterial agent, and a moisturizer is particularly limited. However, in the method of adding various components (one or more of whitening agent, antioxidant, antibacterial agent, and moisturizer) to the silk fiber produced by wild silkworm in advance, and in the cosmetic composition, There is a method of adding a mixture of silk fibers produced by wild silkworms and various components (one or more of whitening agents, antioxidants, antibacterial agents, and moisturizers). In the above method, silk fibers produced by wild silkworms are added. It can be contained in the formulation in powder form.

【0018】

The dosage form and form of the cosmetic composition of the present invention are arbitrary, and may be blended and used in the form of capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments, sheets and the like. it can.

【0019】

The field of application can be applied to various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, lotions, tablets, powders, granules, solids, liquids, gels. , Bubbles, emulsions, sheets, mists, sprays, etc. Appropriate forms for use 1) Pharmaceuticals, 2) Non-pharmaceutical products, 3) Topical or systemic skin cosmetics (eg, lotion, emulsion) , Creams, ointments, lotions, oils, basic cosmetics such as packs, pigments and skin lotions, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, after-shave lotions, pre-show lotions, Makeup cosmetics such as shaving cream, foundation, lipstick, cheek red, eye shadow, eyeliner, mascara, perfume, beautiful nail agent, beautiful nail enamel, beautiful nail enamel remover, poultice, plaster, tape, sheet Agents, patches, aerosols, etc.), 4) Medicinal and / and cosmetic formulations applied to the scalp / hair (eg shampoos, rinses, hair treatments, pre-hair treatments, permanent solutions, hair dyes) , Hair styling products, hair styling products, hair growth / hair growth agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) Lotions used by throwing in bath water, 6) Others, axillary odor Examples thereof include preventive agents, deodorants, deodorants, antiperspirants, sanitary products, sanitary cottons, wet tissues, toothpastes, mouth lotions, mouthwashes, dishwashing agents and the like.

【0020】

The cosmetic composition of the present invention is produced by arbitrarily selecting and using the ingredients and additives exemplified below, if necessary, in addition to the above-mentioned essential ingredients, as long as the effects of the present invention are not impaired. The content in the formulation is not particularly specified, but is usually preferably 0.0001 to 50%.

【0021】

(1) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, bechenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acids, etc. Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanic acid.

【0022】

(2) Alcohol Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

【0023】

(3) Multivalent alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Pentyl glycol, glycerin, pentaerythritol, traytoll, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, martitol, etc.

【0024】

(4) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

【0025】

(5) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylate, etc.

【0026】

(6) Gum, sugar or water-soluble polymer compound Arabic rubber, benzoin rubber, dammar rubber, guayaku fat, Irish moss, karaya rubber, tragant rubber, carob rubber, chitin seed, agar, casein, lactose, fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, Hydroxyalkyl (C2 to C4) chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus to which alkylene (C2 to C4) oxides such as carrageenan, carboxymethyl chitin or chitosan, ethylene oxide are added. Chitin or chitosan oxide, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose , Polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, polyethylene imine and the like.

【0027】

(7) Surfactant Anionic surfactants (alkyl carboxylic acid salts, alkyl sulfonates, alkyl sulfate ester salts, alkyl phosphate ester salts), cationic surfactants (alkyl amine salts, alkyl quaternary ammonium salts), amphoteric surfactants: carboxylic acids Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agents, ether ester-type nonionic surfactants, ester-type nonionic surfactants, block polymer-type nonionic surfactants, nitrogen-containing nonionic surfactants), and other surfactants (natural surfactants, proteins) Hydrolyzate derivatives, high-molecular-weight surfactants, surfactants containing titanium / silicon, fluorocarbon-based surfactants), etc.

【0028】

(8) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxin (vitamin B6), cyanocobalamine (vitamin B12), folic acid, nicotinic acid, pantothenic acid, biotin, choline, inositol, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2) ), Cholecalciferol (vitamin D3), dihydrotaxterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadion (vitamin K3), menadiol (Vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-orizanol, ollotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U, etc.

【0029】

(9) Various additives derived from plant or animal raw materials These are commonly processed processes (eg, crushing, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powdering) depending on the product type and form to be added. , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. can be arbitrarily selected and combined), and can be arbitrarily selected from various materials.

【0030】

The solvent used for extraction may be selected in consideration of the purpose and type of the product to be provided, the processing treatment to be performed later, etc., but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol may be selected. , Isobutanol and other lower alcohols or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, glycerin and other polyhydric alcohols or hydrous polyhydric alcohols, acetone, ethyl acetate and other organic solvents. Alternatively, it is desirable to use a mixed solution of two or more types. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which can be easily removed after extraction may be adopted and used alone or in an arbitrary mixed solution with water. It may be exploited and extracted.

【0031】

When additives derived from plant or animal raw materials are used for whole body or topical external preparations and cosmetics, it not only protects the skin and hair, but also moisturizes, improves the feel and texture, imparts flexibility, and stimulates. Relief of stress by fragrance, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin / hair quality, prevention of rough skin and its improvement, hair growth, hair growth, prevention of hair loss, addition of luster, cleansing effect, In addition to cosmetic effects such as alleviating fatigue, promoting blood flow, and warm bathing effects, it can also be expected to have effects such as scenting, deodorizing, thickening, antiseptic, and buffering.

【0032】

Specific plants (raw medicines) used as raw materials include, for example, almonds (hen peaches), eyes (indigo leaves), aokazura (seifufuji), aoki (Aoki), aogiri or kenasiaogiri (Aokiri), and Aotsuzurafuji (Kibomi). , Aotenma, Acacia, Akasuguri "Fruit", Akatsumekusa, Aka grape, Akaminoki (Logwood), Akamega wrinkle (Akamega wrinkle), Akamino Akane or Seiyou Akane or Akane (Akane grass root), Akayaziou or Jio (Jihuang), Agi (Akikaramatsu), Akikaramatsu , Akinire, Aguai Guasu, Aguahe (Omitengayashi), Akebii (Kidori), Asa (Asakojin), Maruba Asagao or Asagao (Cow cow), Hydrangea (hydrangea), Ashitaba (Tomorrow's leaf), Azuki (Red apricot), Asunaro, Acerola, Achilla (Shokuyoukanna), Anis, Abiu, Abiulana, Abrana, Abemaki "fruit", Avocado, Ama, Amachazuru, Amadokoro (Tamatake), Amana (Hiyu, Hiyu) Hagaytou, Himogatetou, Senninkoku, Sugimorigatetou, Hosoaogateu, Aogaito, Haribiyu, Aosuzuran, Amarantus hypochondriax), Amigasayuri or Baimo (shell mother), Aristromelia (Yurizuisen), Arcana (Arcanna) Alpinia or Katsumadai (Souzuku), Angelica, Apricot or Hongans (Apricot), Ansokko (Asamu), Yellow Sapote, Igakozorina (Gibito), Ikarisou or Yachimataikarisou (Inyoukaku), Igusa (Light-hearted grass), Itadori (Tiger root) ), Ichii (1st place), Strawberry, Ichijiku (no flower fruit "fruit, leaf"), Ichihatsu (Ichihatsu), Ichibi (Fuyu Aiko), Ichiyakuso (Ichiyakuso), Itohimehagi (Distant), Inagomame, Inunazuna (Teilexi) , Inubiyu (Honaga Inubiyu), Rice "Seed, Seed", Inondo "Seed", Ibukijakousou, Irakusa, Iran Iran, Iwa Tobacco (Iwabachi), Iwahiba or Iwamatsu (Makikashiwa), Ingenmame, Woolong Tea (ChiBusanoki), Ukiyagara (Sanryo), Uguisukagra "Fruit", Echinops, Turmeric (Depression), Ukikusa (Floating), Usbasaishin or Keirinsaishin or Oshusaishin (Spicy), Usvenia oi, Usbenita Chiaoi, Uchoran , Utsubogusa (summer dead grass), Udo or Shishiudo (Echinops, Echinops, Echinops), Unyadegato (Uncaria, Cat's Claw), Ubacha, Ume (Elecampane "seed, fruit"), Echinops, Echinops (Kusakokemomo), Unshuumikan (Elecampane) Echinops), turmeric, estragon, elecampane (Echinops goka), elecampane, echinashi (hosobamurasakibarengiku), enishida, enokitake (enokitake), ebisgusa or cassia tora (decision), elcampre, eldermi berry "fruit" Or Prelotus eringi, Enju (Echinops), Peas, Ougi or Kibana Ougi (Yellow), Narco lily or Kagikrumaba Naruko lily (Yellow spirit), Ohisasanoyuki or Sasanoyuki, Ouren (Huangren), Ogatahoken, Okarasuuri (Karokon) Elecampane (Civil engineering incense), Otsuzurafuji (self-defense), Obako (car front child, car front grass), Oobana thistle (Gyoshu leak, white head), Ohashibami (Haruko), Ohashira cactus, Obana Okera or Okera Salsbury (banaba), Obayashabushi "fruit", Oohoshigusa (grain spirit), Omiakatetsu, Omiyayashi, Omugi (barley), Oka, Okazeri (snake bed), Okura "fruit", Oguruma (turning), Okurihigotai ( Echinops, Echinops, Echinops or Echinops(Ginseng), Onamomi (Aoiko), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tenma), Oniyuri or Sasayuri or Hakatayuri (Yuri), Onoeran, Ononis, Ohyo (Split leaf ), Ominaeshi (Defeat) Soy sauce), Oyuko, Dutch karashi (creson), Dutch jelly, Dutch biu, Dutch honeybee, olive "fruit, seed, leaf", oregano, orange "fruit, peel", kaikeigio (ripe yellow), cacao "fruit, peel," Seeds, oysters (persimmon Lol "leaves"), key lizards (fishing wisteria), oysters or citrus fruits (lotus grass), oysters, gaku hydrangeas, cassia, casinoki (fruits), gajutsu (), kashiwa (Maki tree, Maki leaf), Cascarilla, Cascara sagrada, Kasumisou, Kasensou, Kanikusa (Kin Sato), Kaniwa, Carnation, Kanokosou (Yoshikusa root), Gerbera, Pumpkin, Capoknoki "seed", Kahokusansho (Pepper), Gama (Kamao), Kamiyatsude (Tsukusa), Kamukam (Kamokamo), Color, Karakusakeman, Karasuuri or Sinakarasuuri (Wang Gourd), Karasubishak (Half-summer), Karasumugi, Galana "Seeds", Karahoo (Thick), Karaya, Garyu, Karin (wooden gourd), Garusina, Kawamidori, Kawara Psycho (Koryo greens, fluffy grass), Kawajisha, Kawaratake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko (Burning barley, Barley barley), Kawaraninjin (green ), Kawaraninjin ), Kansui (sweet), cantara asa, candelilla, canto, canna, canlan, kistrawberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, nawashiro strawberry, maple strawberry, European ki strawberry), kiwi "fruit, leaf", kikarasuuri (urone), Kiku (Chrysanthemum flower, Shimakangiku, Chosennogiku), Kikutanigiku, Kisage (Azusa), Gishigishi (Sheep root), Kijitsu (Mitsumi), Kizuta, Kidachihakka, Kinua (Kinoa), Kimame, Gymnema sylvestre, Kimenkaku, Cabbage "Immature fruit", Caraway, Gyoryu (Nishikawayanagi, Teiyanagi), Kiraja Saponaria, Kiraya, Lingonberry (Lingonberry), Kinkan "Fruit", Kinkiju, Ginsekai, Kimbusen, Kinma, Kinmizuhiki (Sentsuru grass), Kinran, Ginran, Kinryohen, Guapeva Vermelya, Guava "Fruit", Guayure, Quercus Infectria ), Kukui nuts, Kugenumaran, Kuko (Lingonberry, Lingonberry, Lingonberry leaf, skeleton bark), Kusasugi Kazura (Tenmon Fuyu), Kusunoki, Gooseberry "fruit", Xoninjin (Lingonberry), Kutiti River, Kunugi (Lingonberry) ), Kupuas, Kubeba, Kumazasa, Kumatsuzura (horse whip grass), Cranberry "fruit", chestnut "seed, fruit, astringent skin", Kurukurigo latifolia "fruit", grapefruit "fruit / leaf", bilberry, bilberry (relief) , Gunbainazuna (Sekimei, Sekimeishi), Keigai (Schizonepeta, ), Keito (chicken crown flower, chicken crown), Gekkavidin, Geckage (laurel tree), Kenashi Sartori Ibara (mountain return), Gentiana, Kenponashi (Lingonberry), Lingonberry Lingonberry (Koji, Tachibana, Obeni Mikan, Fukure Mikan, Sagami Koji, Ponkan, Santara (Tachibana bark)), Lingonberry (Monthly flower), Lingonberry, Lingonberry "fruit", Kohone (river bone), Lingonberry (straw book, Kara straw book), Kouryan, Koryokyo (Kora Ginger), Koendoro "Fruit", Koouren (Kohuangren), Koganebana (Yellow Gon), Lingonberry (Koshitachibana), Cocoyashi "Fruit", Goshuyu (Wu Silverberry), Gosho Strawberry (Covered Bonko), Kosho (Kousho) Lingonberry), Cosmos, Copaiba Balsam, Coffee "Seeds, Leaves", Kobushi or Mokuren (Spicy), Gobo (Beef, Beef), Kobotanzuru, Gomanohagusa (Genjin), Garbage (Gomiko), Sanekazura or Binankazura or Matsubusa (Wheat), Cola Acminata "Seeds", Cola Bella "Seeds", Colony Lha, Koroha "Fruits", Colombo, Conzlango, Lingonberry, Lingonberry, Comfrey (Lingonberry), Sesal (Sesal Asa), Saihailan, Sakaneran Ezosakaneran), Sakishima Button Duru or Sina Button DuruPerilla frutescens (perilla), cherry (Oshimazakura, Yamazakura, Oyamazakura, Edohigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaves, flowers, fruits, bark (cherry bark)") Cherry, pomegranate, sasa, sasabaginran, southernka, sagiomodaka (sawataki), sweet potato, sugar cane, sugar cane, sanebutonatsume (sour vine), saffron (banbokuhana, saibokuhana), saposira, sapotea mariyo, zabon "fruit" "Fruit", Saranshito (sand indigo sashimi), Sawagikyo (Sankyosai), Sawagurumi (Sankoto), Sankaku cactus, Sangre degrad (Croton), Sanshikuyousou, Sanshichininjin (37 carrots), Sanshuyu (Sanshuyu) ), Sansho (Sansho), Sandscon (Yamazukon), Shea (Karite), Cyanoki "Fruit", Shiitake (Shiitake), Zion (Shien), Shikakumame, Jikitaris, Shikunshi (Emperor), Perilla or Aojiso or Chirimendiso Or Katamenjiso (Shiso leaf, Shisoko), Shitan, Shinanoki, Shinahoonoki, Shinarengyo (Cherry), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishimeji, Bunashimeji, Hongjimeshi, Shirotamogitake), Shimokuren (Spicy) Shajin (perilla), jasmine (matsurika), janohige (wheat gate winter), juurokusasage, shukukonkasumiso, shukushamitsu (sand), shuro "fruit", shunran, ginger, ginger ), Japanese pepper (Tsuneyama), Japanese pepper (iris, iris root), Japanese pepper "fruit", perilla "seed", silane (byakyu), white butterfly "seed", white pepper (clover), white perilla (chicken bone grass), white perilla Iris (Nioiirisu), Shirobanatsuta "Flower", Shirobana Rupin, Shinkonasaku Silbra, Jinchoge (Mizuika, Mizukahana, Shinchohana), Shinnamon, Watermelon (Pepper), Suiba (Acid), Swimberry "Fruit", Star Apple, Stevia , StrikeRoberry "Fruit", Suzusaiko (Sir Xu Chang), Sugina (Question), Suberihiyu (Dendrobium moniliformis, Dendrobium moniliformis), Sumomo "Fruit", Surugaran (Oran), Dendrobium moniliformis, Dendrobium moniliformis, Dendrobium moniliformis , Dendrobium moniliformis, Dendrobium moniliformis, Dendrobium moniliformis, Dendrobium moniliformis (Maronier), Dendrobium moniliformis, Dendrobium moniliformis, Dendrobium moniliformis (Elder), Dendrobium moniliformis (Juniper, Dendrobium moniliformi), Dendrobium moniliformis, Dendrobium moniliformis, Dendrobium moniliformis Hakka or Seiyoyama Hakka, Seiyouwasabi, Sekisho (Stone iris), Sekoku (Sakura Sekoku, Kouki Sekoku, Oobana Sekoku, Okinawa Sekoku, Hon Sekoku, Kocho Sekoku, Shikaku Sekoku, Kibanano Sekoku) , Zeniaoi, Hiroha Senega, Senega, Seri, Celoli, Senshinren (Dendrobium moniliformis), Sendan, Sennin cactus, Senna "fruit, leaf", Senninsou (Dandelion), Senboku, Souka (grass), Elephant gechu, Soshinroubai, Soba " Seeds, Somemonoimo, Soramame, Daiou (Dandelion), Daikon, Daidai (Orange bark, Dendrobium moniliformis), Takasagorurihigotai (Southeastern indigo sashimi), Takasaburo (Dendrobium moniliformis), Takatodai (Dandrobium moniliformis), Takawarabi , Dark Sweet Cherry "Fruit", Tachiaoi, Tachijakousou (Time, Hyakurika), Tachidokoro (Hikai), Tachiyanagi, Tamaland "Seed", Onion, Tamashiba (Spicy), Taranoki "Fruit, Leaf, Root bark", Tarayou (Large leaf) Winter blue, one-leaf tea, bittersweet tea, bittersweet tea), dalia (tenjiku button), tarwi, tankirimame, tanshiuchiwa, tanjin (tanjin), dandelion (Kamoei) or white dandelion or mouko dandelion, dammar, cherry "fruit", chigaya "Fruits, roots, buds", Dendrobium moniliformis (Takebushi carrot), Chicoli, Chankapiedra (Kidachikomikansou), Tulip, Choconostay, Chosen thistle (Artichoke), Chosendaiou (Dandelion), Chosennile (Dandelion),Choreimaitake (Inori), Chorogi, Tsukimisou, Tsukushisakaneran, Tsukuritake (Mushroom), Tsuchiakebi, Tsubaki, Tsubokusa, Tsumekusa (lacquer grass), Tsuyukusa (duck peanut), Tsuruazuki (red peanut) ), Tsuruna (Apricot), Tsuruninjin (Four leaf ginseng), Tsurumame, Tsuwabuki, Deiko, Teuchigurumi, Duberry "Fruit", Tengusa, Tencha (Chinese tea), Tendaiuyaku (Peanut), Touga (Winter melon), Toukagikazura, Togarashi (Bansho), Tokinsenka (Marigold), Tosaikachi, Tounabena (Kawadashi), Corn or corn hair (Southern barbarian hair), Tounezumimochi (Sadako), Torindou or Chosenrindou (Ryubori), Tokusa (Wooden), Tokon (spitting root), Tochu (Tochu "bark, leaf, root"), Toneriko (hata bark), tomato, tragant, triacanthos "seed", tormentilla, dronoki, trolley aoi, sword bean, niece rear berry "fruit", sword bean or yamanoimo (Yamayaku), Nagiikada (Butcher Bloom), Naginatakouju, Nazuna, Rapeseed, Sword Bean or Tatehaki (Sword Bean), Natsumikan, Natsume (Otsubo), Naniwaibara (Kinsakurako), Navena (Continued), Nameko, Nankinmame ( Peanuts), sword bean (sword bean), sword bean, nigaki (bitter tree), sardine, rice bean, sword bean, sword bean (bone-bearing tree "fruits, flowers, stems, leaves"), garlic (daiseki), onion, Nemunoki or Nebu or Nebi or Nemurinoki or Jigokubana (Gaijo), Noazami (Oyabu), Nozenkazura (Ryokan), Nogeito, Nodake (Maekhu), Novara, Nomomo, Peanut "Fruit", Hibiscus (Bussouge, Fuulinbusel) Hailindou, Hauchiwa, Pau Dose, Hakamaurabosi (bone crushing supplement), Hakukayumatou, Hakusanchidori, Hakusen (Peanut skin), Hakuruberry "fruit", Hakobe (Proliferation), Hashibami (Haruko), Hashiridokoro (Roto root), Basil , Hass (lotus, lotus meat, lotus), peanuts (Dutch jelly), sword bean, sword bean, beeOr Madake (boiled bamboo), patchouli, hazelnut (lightly loaded, lightly loaded leaves), hassho bean, hanasuge (knowing mother), banana, hanahakka, hanabishi (bitter melon, shishitsuri), vanilla bins, papaya, hahacogusa (steamed grass), pahalobobo, hub "Whole plant, stem, leaf", paprika, hazelnut, hazelnut (bitter melon), hazelnut (bitter melon), hamanasu (maikai flower), palm, rose (rose), balata, agaricus, agaricus, agaricus, Usukimori no Casa), Haran, Pariurus (Agaricus campestris), Parietaria, Halkanran, Balsamina (Bitter melon, Nigauri), Harunire (Bitter melon, Agaricus campestrum, Leaf leaf), Barbasco, Harlindou, Handaikai (Agaricus campestris), Pannoki, Hikaru (Party), Pecan nuts, Higanbana (Stone sardine, Saka vine), Higurumadaria, Higotai, Hishi (Ryomi), Pistachio, Beet, Hitotsuba (Stone reed), Hitotsuba Enishida, Hinagiku (Daisy), Hinatainokozuchi ( Cow knee), Hinachiyodori, Hinoki, Hiba, Himashi, Sunflower, Peaman, Himeuzu (Ten Aoi), Himegama (Agaricus), Himemuyouran, Pimenta "Fruit", Byakushi, Byakukyu, Hiyu "Fruit", Hiyokomame, Hiramame , Hirohaokinagusa (white-headed old man), Biwa "fruits, leaves, stems", binro (large clothing skin, bitter melon), puer tea, futoukazura (southern rattan), fuki, fukitanpopo (fufuyuhana, subfuyuha), Fujibakama (orchid grass) , Fujimame (Hazelnut), Fujimodoki (Chojizakura, Ashihana), Grape "Fruits, Peel, Seeds, Leaves", Beech, Fuyumusinatsukusatake (Winterworm summer grass), Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant " "Fruits", Blackberry, Branchen, Plum "Fruits", Full Celaria, Blueberries (Agaricus campestris), Prunes, Floral Blanca, Blonde psyllium, Bundo (green beans), Hazelnuts, Bitter melon, Heneken, Veradonna, Berry "Fruits", Persair, Perbianberg, Pereschia grandifolia, BenkeisouIs Ikikusa (Keiten), Boysenberry "fruit", Magnolia obovata or Niwakusa or Nendo or Hahakigi Kokia (Ginko), Magnolia obovata, Pouteria obovata (Pouteria obovata, Acute child, Pouteria obovata), Pouteria sapota, Pouteria lucuma, Magnolia obovata, Magnolia obovata, Magnolia obovata (Torone), Magnolia obovata (Wakopaku, Park), Bokeh (Wooden), Pouteria obovata (Bitter yok), Pouteria obovata, Pouteria obovata (Aoi), Pouteria obovata (Keiten 37), Pouteria obovata Bodaiju (Bodhi), Magnolia obovata, Borigi (Rurichisha), Bordeaux, Whiterberry "Fruit", Pouteria obovata (Magnolia obovata, Daigei), Magnolia obovata (Tetsukin Ishibuki, Jakuyama Ishibuki), Maizuru Tennansho (Tennansei) , Maitake (Magnolia obovata), Maca, Macademia nuts, Margaret (Mokushungiku), Makuri (Seaman grass), Magnolia splengeri, Masalanduba, Masalanzuva de Searer, Machelia de Boy, Mashua (Tamanouzenharen, Kyukon) Kinrenka), Matatabi (tree heaven), Matsukasa, pine "leaves, bark, roots", Matta Oryo, Matico (Cordoncillo), Mayoram (Hanahakka), Mulberry "Fruits", Marumero, Malein (Biroudomouzuika), Mango , Mangostin, Mansagna, Manshugurumi, Mandarin "Fruit", Mannentake (Reishi), Kijitsu (Magnolia obovata "Fruit"), Magnolia obovata or Mizuasagao (Ryutongusa), Mizokakushi (Half-side lotus), Misohagi (Senbana) , Michiyanagi or Niwayanagi (Hen), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle fruit "fruit", Mirula, Mirobaran, Wheatwaragiku, Mukuge (wooden persimmon), Mukunoki, Mukuroji Magnolia obovata (purple pearl), murasaki corn, murasaki natsufuji (konmei chicken blood wisteria), megakansa opuntica, mehajiki (masu mother grass), mebougi, mematsuyoigusa (evening primrose), melaloika, melilote, melon "fruit", moso chiku, mokukirin (Koshoboku), Mochinoki, Mokko (Wood incense), Momijibadaio, Peach (Peach "leaves, seeds, flowers, fruits"), Moyashi, Morero cherry "Fruits", Moroheiya (yellow hemp), Yakawamurasakiimo, Yakuchi (Masuchi), Willow (willow) , Yagurumahakka, Yakon, Yashabushi (Yaguruma) or Himeyashabushi or Obayashabushi "Fruit, peel, fruit ear", Yachiyanagi, Yatsude (octagonal plate), Yadorigi (willow parasite), Yanagi (Kawayanagi, Tachiyanagi, Shidareyanagi, Akameyanagi) Willow, Willow, Willow, Willow, Willow, Willow, Palm, Willow, Willow, Willow, Willow, Willow, Willow, Stem, Willow, Willow, Willow, Willow, Willow , Yamagobo (Commercial Land), Willow (Yamaharu), Yamamomo (Yang Plum Skin), Yukka or Frevifolia, Yuzu "Fruit", Yuri, Yoroigusa, Rygan (Raimaru), Lime "Fruit", Willow, Lacanca "Fruit", Raspberry "leaves, fruits", ratania (clameria), lacquer or echalot (willow), lavender, willow (willow), willow (willow, willow, willow), apples "fruits, seeds, leaves, roots", willow, rubas or Suabisimusu (Jinryo), Ruritama thistle (Willow willow, Willow indigo), Reishi (willow, willow nucleus), lettuce (chisha), red currant "fruit", red pitaya, lemon "fruit", lemongrass, willow or Examples include willow (willow), willow, willow (willow), willow, locon (yoshi, willow), loganberry "fruit", rose hip (nobara), wasabi, and willow (willow).Yukka or Frevifolia, Yuzu "Fruit", Yuri, Yoroigusa, Lychee (Raimaru), Lime "Fruit", Limegi, Lacanca "Fruit", Raspberry "Leaf, Fruit", Latania (Clameria), Lakkyo or Eshalot (Small White), Lavender, Ryugan (dragon eye meat), Ryuzetsuran (Aonoryu Zetsuran, Fukurin Ryuzetsuran), apple "fruits, seeds, leaves, roots", Lindou, Rubas or Suabisimus (Ryo), Ruritama thistle (Urajirohigotai, Shinsai indigo stab), Lychee (Litchi, Lychee nuclei), Lettuce (Chisha), Red currant "Fruit", Red Pitaya, Lemon "Fruit", Lemongrass, Litchi or Shinarengyo (Litchi), Litchi, Litchi, Litchi, Lokon (Yoshi, Lychee), Loganberry "fruit", rose hips (nobara), wasabi, cotton squirrel (lychee flower), etc.

【0033】

Seaweeds include seaweeds [green algae: Chlorella bulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usbaaonori, Sujiaonori, Hiraaonori, Bowaonori, Hosoedaaonori), Anaaosa (Aosa)], Seaweed (Macomb, Risilimb, Hosomecomb, Mitsuishikonbu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis pirifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usbaumiuchiwa Seaweed, Akabaumiuchiwa, Konaumiuchiwa, Okinawauchiwa, Usuyukiuchiwa, Etsukiumiuchiwa], Seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hirakusa, Onikusa, Obakusa, Kataobakusa, Yatabegusa Kirinsai, Byakushin Kirinsai, Tsunomata, Green laver, Tochaka (Yahazutsunomata), Ezotsunomata, Togetsunomata, Hirakotoji, Kotojitsunomata, Ibotsunomata, Marubatsunomata, Hiracotoji, Suginori, Shikinnori Listed as a thing.

【0034】

In addition, other algae, for example, green algae (genus Cramidomonas: genus Cramidomonas, Akayukimo, genus Dunariella: Dunaliera, genus Chlorococcus: chlorococcus, genus Quanomimo: genus Quanomimo, genus Volvox: genus Ohigemawari, genus Volvox, genus Palmera, genus Yotsumemo Hizaori, Aomidoro, Tsurugimidoro, Hibimidoro: Hibimidoro, Aosa: Anaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Frichera, Shiogusa: Oshiogusa, Asamidori Shiogusa, Kawashiogusa, Marimo, Baronia Genus Magatamamo: Genus Magata, Genus Iwazuta: Genus Fusaiwazuta, Surikogizuta, Herai Wazuta, Kurokizuta, Genus Hanemo, Genus Mill: Mill, Cromil, Sakibuchimil, Nagamil, Hiramil, Genus Kasanori: Kasanori Genus, Tsuzumimo, Kikkogusa: Kikkogusa, Hitoegusa: Hitoegusa, Hirohanohitoegusa, Usuhitoegusa, Motsukihitoe, Sayamidoro, Kunshoumo, Sumiremo: Sumiremo, Hoshimidoro, Fushinashimidoro, etc.).

【0035】

Cyanobacteria (Suizenji nori: Suizenji nori, Aoko, Nostoc: Kawatake, Nostoc commune, Hassai, Oscillatoria, Lasenmo (Spirulina): Spirulina, Trichodesmium (Aiacasio), etc.).

【0036】

Brown algae (Piraela: Pyraela, Shiomidoro: Nagami Shiomidoro, Isogrape: Isogrape, Isogawara: Isogawara, Kurogashira: Gunsenkurogashira, Kashirazaki: Kashirazaki, Muchimo: Muchimo, Hiramuchimo, Keberigusa, Amijigusa: , Sanadagusa: Sanadagusa, Fukurinamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahazu, Yahazugusa, Uraboshiyahazu, Jigamigusa: Jigamigusa, Umiuchiwa: Umiuchiwa, Konaumiuchiwa : Nabarimo, Chasomen genus: Motsukichasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawamozuku genus: Okinawamozuku, Nisefutomozuku genus: Nisefutomozuku, Futomozuku genus: Futomozuku, Ishimozuku genus: Ishimozuku Fake genus, Mozuku genus: Mozuku, Ishige genus: Ishige, Iroro, Ichimegasa genus: Ichimegasa, Keyari genus: Keyari, Umibosu genus: Umibos, Urushigusa genus: Urushigusa, Keurusigusa, Tobaccogusa : Habanori, Seiyohabanori: Seiyohabanori, Common Bukuro: Common Bukuro, Ezobukuro: Ezobukuro, Fukuronori: Fukuronori, Watamo, Chishimafukuronori: Chishimafukuronori, Kagomenori: Kagomenori, Muraridori: Murachidori Genus: Iwahige, Yokojimanori: Yokojimanori, Kayamonori: Kayamonori, Uikyomo: Uikyomo, Tsurumo: Tsurumo, Aname: Aname, Sujime: Sujime, Misujikonbu: Misujikonbu, Atsubamisujikonbu, Onikombu, Goheikonbu, Nagakombu, Peascomb, Ochijimikonbu, Tororokonbu: Tororokonbu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikonbu:Kikuishikonbu, Nejirekonbu: Nejirekonbu, Kuroshiome: Kuroshiome, Nekoashikonbu: Nekoashikonbu, Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakame Ezoishige: Ezoishige, Yabanemoku Genus: Uganomoku, Joromoku, Hiemoku, Hondawara Genus: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yatsumatamoku, Umitoranoo, Oobamoku Genus Sargassum: Genus Sargassum, Genus Arthrothamnus: Genus Oukimo, Genus Sargassum: Genus Sargassum, Genus Kayamonori: Kayamonori, etc.)

【0037】

Red algae (genus Ushikenori: Ushikenori, Funori no Ushike, Amanori: Asakusanori, Susabinori, Upruinori, Oniamanori, Tasa, Firitasa, Benitasa, Rodcolton: Milnobeni, Akebonomozuku Genus: Pyropia, Pyropia, Pyropia, Pyropia, Pyropia: Pyropia, Pyropia, Pyropia: Pyropia, Pyropia: Pyropia, Pyropia: Pyropia, Pyropia, Pyropia, Pyropia, Pyropia, Pyropia, Pyropia Genus: Tamai Tadaki, Kagikenori Genus: Kaginori, Kagikenori, Tengusa Genus: Himetengusa, Hitengusa, Oobusa, Nambugusa, Kohira, Yohira, Kinukusa, Hibiroudo genus: Hibiroudo, Himehibiroud, Isomememodoki Genus Michigaesou: Genus Michigaesou, Genus Ryumonsou: Genus Ryumonsou, Hera Ryumon, Genus Nisekarekigusa: Genus Nisekarekigusa, Genus Okitsubara: Genus Oobaokitsubara, Genus Akaba: Akaba, Maruba Akaba, Genus Naminohana: Genus Akaba, Maruba Akaba, Genus Naminohana: Genus Hosoba Naminohana Genus Ivanokawa: Genus Etsuki Iwanokawa, Genus Kainokawa: Genus Kainokawa, Genus Caninote: Genus Caninote, Genus Coral: Genus Coral, Genus Mukadenori: Mukadenori, Sujimukade, Katanori, Hiramukade, Kyonohimo, Sakuranori, Nikumukade Kuronurakusa, Omukadenori, Hirakintoki: Hirakintoki, Matabo: Matabo, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Hitotsumatsu, Fushikintoki, Tsunomukade, Nagakintoki Genus Nagaobane: Genus Nagaobane, Genus Funori: Hanafunori, Fukurofunori, Mafunori, Genus Karekigusa: Genus Karekigusa, Genus Tosakamodoki: Hosobanotosakamodoki, Hirohanotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodoki Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada genus: Kinuhada, Ezotosaka genus: Ezotosaka, Tsukasanori genus: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo genus: Honoo, Hikagenoi Genus: Venice nago, Suskakebeni: Suskakebeni, Okamuragusa: Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari Tachiibara, Kagiibaranori, Genus Kijinoo: Genus Kijinoo, Genus Isodantsu: Genus Isodantsu, Genus Atsubanori: Genus Atsubanori, Genus Ogonori:Gracilaria, vine sardine, shiramo, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine, sardine Genus: Hachijotengusamodoki, Fushikrenori genus: Fushikrenori, Namiiwatake genus: Namiiwatake, Kaimensou genus: Gracilaria, Gracilaria: Gracilaria, Saimi genus: Itanigusa, Saimi, Harigane, Hasujigusa Genus Kurohaginnansou: Genus Kurohaginnansou, Genus Akabaginnansou: Genus Akabaginnansou, Genus Hishibukuro: Genus Hishibukuro, Genus Madaragusa: Togemadara, Etsukimadara, Genus Taoyagisou: Genus Gracilaria, Genus Gracilaria, Genus Gracilaria, Genus Gracilaria Genus: Gracilaria, Darus: Darus, Masagoshibari, Anadarus, Uevagusa: Uevagusa, Benifukuronori: Benifukuronori, Fushitsunagi: Fushitsunagi, Himefushitsunagi, Hirohafushitsunagi, Watunagisou , Hariigisu, Hanegis, Amixa, Egonori genus: Egonori, Futoigis, Saeda genus: Saeda, Chirimomiji genus: Chirimomiji, Konohanari family: Habutaenori, Konohanori, Gracilaria, Usbeni genus: Usbeni, Hasujiginusu : Sujiginu, Atsubasujiginu, Haiusbanori: Gracilaria, Jaleusbanori, Sujiusbanori, Haiusbanori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Ayanishiki: Ayanishiki Genus Dajimomodoki, Genus Itogusa: Genus Gracilaria, Genus Futoigusa, Genus Makuri: Genus Gracilaria, Genus Gracilaria:Hanayanagi, Yuna, Yanaginori, Motsureyuna, Benyanagikori, Mosayanagi, Sasabayanaginori, Sozo: Kurosozo, Kobusozo, Hanesozo, Sozonohana, Hanegusa: Hanegusa, Kehanegusa, Kozanemo Genus: Kikuhiodoshi, Hiodoshigusa, Usubahiodoshi, Isomegusa Genus: Isomegusa, Sujinashigusa Genus: Sujinashigusa, Isobasho Genus: Isobasho, Fujimatsumo: Fujimatsumo, Nokogirihiba: Fujimatsumo, Nokogirihiba: Hakesakikinokogirihiba Ideyukogome, genus Okichimozuku: genus Okichimozuku, genus Itogusa, genus Chinorimo: chinorimo, genus Chisujinori: genus Chisujinori, etc.).

【0038】

Axial algae (Charales, Shiratamamo, Nitellopsis obtusa: Nitellopsis obtusa, Rycnotamunus, Flaskoli: Nitella flexilis, Chaboflax, Tripera, etc.), Yellow algae (Ochromonas vische: Hikarimo, etc.), etc.

【0039】

In addition, as materials derived from animal-based raw materials, chicken crown extract, cow or pig, human placenta extract, stomach of cow or pig, duodenum, intestine, extract of spleen or its decomposition product, brain tissue of cow or pig. Extracts, collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle / pigs or fish, collagen derivatives such as water-soluble collagen or acylated collagen, elastin or elastin hydrolyzate of cattle or pigs (acid, alkali, Enzymes, etc.) or water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk proteins and their degradation products or their derivatives, pig or bovine blood cell proteolytic products (globin peptides), bovine or pig hemeglobin degradation products (Hemin, hemetin, heme, protoheme, heme iron, etc.), milk, casein and its decomposition products or their derivatives, defatted milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, Nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

【0040】

Further, as a material derived from a plant or animal-based raw material, any site, cell, tissue, organ, metabolite or the like derived from a genetically modified product or a cell fusion can be used. Further, for example, an undifferentiated cell group or a cell group in the process of differentiation, which is obtained by culturing an arbitrary site, cell, tissue, organ or the like, can also be used.

【0041】

(10) Marine components Seawater such as deep water, such as seawater salt, dried seawater, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the dead sea or the Atlantic or Pacific sea, sea mud or mud (fango), for example. , Italy Fango, Germany Fango, Eifel Fango, Freiburg Fango, etc. Sea mud or mud (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide , Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitokuishi, Kuroyaishi, etc.

【0042】

(11) Microbial culture metabolites Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or lactic acid bacterium metabolite, mold or lactic acid bacterium extract, natto bacterium metabolite, natto extract, fermented rice extract, rice bran (red bran, white bran) ) Fermented extract, Euglena extract or its decomposition product or its water-soluble derivative, trehalose or its derivative, lactic acid fermented product of raw milk or defatted milk powder, lactic acid bacterium fermented product of legume family plant, lactic acid bacterium fermented product of coconut palm plant, etc.

【0043】

(12) α-Hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

【0044】

(13) Inorganic pigment Silica anhydride, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjo, chromium oxide, chromium hydroxide, carbon black, caramine, etc.

【0045】

(14) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercury oxide, mercury chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether), etc.

【0046】

(15) Turnover promoting action / cell activator Hydroquinone, Lactobacillus extract, Placenta extract, Reishi extract, Vitamin A, Vitamin E, Allantin, Spleen extract, Chest gland extract, Yeast extract, Fermented milk extract, Plant extract (Aloe, Aloe vera, Ogon, Sugina, Gentiana, Gobo, Murasaki, Carrot, Hamamelis, Hop, Yokuinin, Odorikosou, Senburi, Touki, Tokinsenka, Amacha, Otogirisou, Cucumber, Tachijakousou, Mannenrou, Parsley) etc.

【0047】

(16) Astringent Succinic acid, allantin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds), etc.

【0048】

(17) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

【0049】

(18) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camfur, dl-campur, hydrocortisone, guaiazulene, chamazulene, chlorpheniramine maleate, glycyrrhizinic acid or its salts, glycyrrhetinic acid or its salts. Salt, agetsu extract, licorice extract, purple extract, propolis, etc.

【0050】

(19) Elastase activity inhibitor Diisopropyl floolophosphate, plant extracts (Ogon, comfrey, clara, mulberry leaves, comfrey, geranium thunbergii, comfrey, salvia, elderberry, bodaiju, buttonpi), seaweed extract, etc.

【0051】

(20) Hair preparation Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantoll, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, thioglycolic acid, etc.

【0052】

(21) Antiandrogen Follicular hormones (estron, estradiol, ethinyl estradiol, etc.), isoflavones, oxendolone, etc.

【0053】

(22) Peripheral vascular blood flow promoter Vitamin E or its derivatives, Swertia japonica extract, garlic extract, ginseng extract, aloe extract, gentiana extract, touki extract, cepharanthin, carpronium chloride, minoxidil, etc.

【0054】

(23) Stimulant Togarashi tincture, nonyl acid vanilamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate, etc.

【0055】

(24) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

【0056】

(25) Anti-seborrheic agent Pyridoxine or its derivatives, sulfur, vitamin B6, etc.

【0057】

(26) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

【0058】

(27) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate peroxide, sodium bromide, potassium bromide, sodium pyrophosphate peroxide, sodium orthophosphate peroxide , Sodium hydrogen peroxide adduct, Sodium hydrogen peroxide adduct, Sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

【0059】

(28) Hair remover Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.

【0060】

(29) Hair swelling agent Ethanolamine, urea, guanidine, etc.

【0061】

(30) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, hydrochloric acid 2,4-diaminophenoxyethanol , Hydrochloride 2,4-diaminophenol, Toluene Hydrochloride-2,5-Diamine, Nitroparaphenylenediamine Hydrochloride, Paraphenylenediamine Hydrochloride, N-Phenylparaphenylenediamine Hydrochloride, Metaphenylenediamine Hydrochloride, Orthoaminophenol, N-Phenyl Acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, para-phenylenediamine, paramethylaminophenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2) -Hydroxyethylamino) -2-methylphenol, N-phenylparaminophenol, metaaminophenol, metaphenylenediamine, 5-amino orthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthosulfate Chlorparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaminophenol sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, parasulfate Nitrometaphenylenediamine, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, fluoroglucolcin, gallic acid, resorcin, tannic acid, 2- Hydroxy-5-nitro-2',4'-Diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

【0062】

(31) Fragrance Natural animal fragrances such as jaco, civet, castorium, amberglis, anis essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, uikyo essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamon essential oil, guayakwood essential oil, cumin essential oil, black letters Essential oil, Kay skin essential oil, Cinnamon essential oil, Geranium essential oil, Copaiba balsam essential oil, Korean del essential oil, Perilla essential oil, Cedarwood essential oil, Citronella essential oil, Jasmine essential oil, Gingergrass essential oil, Cedar essential oil, Sparemint essential oil, Western pepper essential oil, Otsuka essential oil, Tuberose essential oil, Dingji essential oil, Orange flower essential oil, Winter green essential oil, Trubalsam essential oil, Bachury essential oil, Rose essential oil, Palmarosa essential oil, Higashi essential oil, Hiba essential oil, Sandan essential oil, Petitgrain essential oil, Bay essential oil, Bechiba essential oil, Bergamot essential oil, Peruvian essential oil Essential oils, boad rose essential oils, sardine essential oils, mandarin essential oils, eucalyptus essential oils, lime essential oils, lavender essential oils, linaroe essential oils, lemongrass essential oils, lemon essential oils, rosemary (mannen wax) essential oils, Japanese hacker essential oils and other vegetable fragrances, and other synthetics Perfume etc.

【0063】

(32) Pigments / colorants Red cabbage pigment, red rice pigment, red rice pigment, annatto pigment, squid pigment, corn pigment, enju pigment, okiami pigment, persimmon pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, Whole buckwheat pigment, cherry pigment, seaweed pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple annatto pigment, lac pigment, rutin, etc.

【0064】

(33) Other Hormones, metal ion blockers, pH regulators, chelating agents, preservatives / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products , Animal / vegetable polysaccharides and their degradation products, blood flow promoters, anti-inflammatory agents / anti-inflammatory agents / anti-allergic agents, wound healing agents, foam thickeners, thickeners, enzymes, purified water (electronic water, small clusters) , Etc.), oral agents, deodorant / deodorant, etc., and when used in combination with these, additive or synergistic improvement of the effect of the present invention or other cosmetic effects can be expected.

【0065】

The method of addition to the cosmetic composition of the present invention may be added in advance or may be added during production, and may be appropriately selected in consideration of workability.

【0066】

[Example]

Hereinafter, production examples, test examples, and prescription examples will be described, but the present invention is not limited thereto.

【0067】

(Production Example 1) Silk fibers produced by wild silkworms are crushed and powdered, and 100 g of a 5% aqueous solution of vitamin C phosphate magnesium salt (manufactured by Sigma) is added to 500 g of silk fibers and mixed well. Then, after drying in a vacuum dryer, it is pulverized to obtain about 500 g of powder.

【0068】

(Production Example 2) Silk fibers produced by wild silkworms are crushed and powdered, and 100 g of a 5% ethanol aqueous solution of vitamin E (manufactured by Sigma) is added to 500 g of the silk fibers and mixed well. Then, after drying in a vacuum dryer, it is pulverized to obtain about 500 g of powder.

【0069】

(Production Example 3) Silk fibers produced by wild silkworms are crushed and powdered, and 50 g of a 5% ethanol aqueous solution of methyl parahydroxybenzoate (manufactured by Sigma) is added to 500 g of silk fibers and mixed well. Then, after drying in a vacuum dryer, it is pulverized to obtain about 500 g of powder.

【0070】

(Production Example 4) Silk fibers produced by wild silkworms are crushed and powdered, and 50 g of a 10% aqueous solution of glycerin (manufactured by Sigma) is added to 500 g of the powdered silk fibers and mixed well. Then, after drying in a vacuum dryer, it is pulverized to obtain about 500 g of powder.

【0071】

(Test 1) Whitening test In order to evaluate the whitening effect, a pigmentation inhibitory test using brown guinea pigs was conducted. "Test method and evaluation method" Brown guinea pig (WM guinea pig 13-week-old male) 1 group 3 animals, 6 animals in total, hair clippers were used to cut the back hair, and the test site (3 x 3 cm)²) Was prepared in 4 places. Apply 72 μL of 0.005% (w / v) 8-methoxypsoralen (Acrs) dissolved in acetone to the test site in an appropriate amount, and then UVA (2J / cm) using a Toshiba FL-20BLB lamp.²) Was irradiated. After irradiation, an appropriate amount of sample or control was applied to the test site at two locations. The number of applications was once a day, 5 days a week for a total of 3 weeks. The day after the final application, the lightness of the skin was measured at 3 points on each test site using a color difference meter (CR-200 manufactured by Minolta), and the value obtained by subtracting the lightness of the test site measured before the test was used as the pigmentation index and used as the sample. The pigmentation index is calculated from the average value by measuring the brightness of each test site 6 times (total number of measurements of the two test sites where the sample was applied) (the larger the index, the stronger the pigmentation), and the results are shown in the table. Shown in 1. The sample is a powder obtained by adsorbing a 5% aqueous solution of vitamin C phosphate magnesium salt (manufactured by Sigma) on the silk fiber produced by the wild silkworm obtained in Production Example 1 of the present invention in the following emulsion formulation. Prepared by adding. As a control, 0.05% of vitamin C phosphate magnesium salt (manufactured by Sigma) was added to the following emulsion to prepare the mixture.

【0072】

(Emulsion prescription) (mass%) 1. Stearic acid 2.5 2. Cetyl alcohol 1.5 3. Vaseline 5.0 4. Liquid paraffin 10.0 5.NIKKOL TO-10 (manufactured by Nikko Chemicals) 2.0 6. Polyethylene glycol 1500 3.0 7. Triethanolamine 1.0 8. Carboxypolymer 0.05 9. Sodium bisulfite 0.01 10. Ethylparaben 0.3 11. Residual with 100 purified water [0073]

<img file="JP2003192530A_D0001.tif" />【0074】

(Test Results) As shown in Table 1, the powder obtained by adsorbing a 5% aqueous solution of vitamin C phosphate magnesium salt on the silk fiber produced by the wild silkworm of the present invention was compared with the control (vitamin C phosphate magnesium salt only). It was confirmed that the pigmentation index was low and the whitening effect was high.

【0075】

(Test 2) Antioxidant test In order to evaluate the antioxidant effect, an antioxidant test was performed on the skin of guinea pigs. "Test method and evaluation method" Hair clippers were used to cut the back hair of a total of 6 guinea pigs, 3 per group, and the test site (3 x 3 cm).²) Was prepared in 6 places. An appropriate amount of the sample or control shown below was applied to the test site at two locations each, and one non-applied plot was provided as a blank plot. In addition, the number of applications is once a day, 5 days a week for a total of 3 weeks, and on the day after the final application, lipids are extracted from the skin using acetone by the cup method, and the lipid peroxidation inhibitory effect (peroxidation) The lipid production inhibition rate) was tested using the TBA method. The results are shown in Table 2. As a sample, 1 mg of powder obtained by adsorbing a 5% ethanol aqueous solution of vitamin E (manufactured by Sigma) on silk fibers produced by wild silkworms obtained in Production Example 2 of the present invention is liquid paraffin (manufactured by Wako Pure Chemical Industries, Ltd.). The one prepared by dispersing in 100 mg was used. As a control, 1 mg of vitamin E (manufactured by Sigma) was dispersed in 100 mg of liquid paraffin (manufactured by Wako Pure Chemical Industries, Ltd.).

【0076】

<img file="JP2003192530A_D0002.tif" />【0077】

(Test Results) As shown in Table 2, the powder obtained by adsorbing a 5% aqueous solution of vitamin E on the silk fiber produced by the wild silkworm of the present invention has a stronger inhibitory effect on lipid peroxide production as compared with the control (vitamin E only). It was confirmed that it had.

【0078】

(Test 3) Antibacterial test An antibacterial test on human skin was performed to evaluate the anti-acid effect. "Test method and evaluation method" As a monitor, 5 men and women in their 20s to 50s were tested on the inside of the left and right forearms (3 x 3 cm).²) Was prepared in 3 places each on the left and right. An appropriate amount of each sample or control (0.5 mg of methyl parahydroxybenzoate dispersed in liquid paraffin) was applied to the test site, and one non-applied group was provided as a blank group. The number of applications was once a day, 7 days a week for a total of 3 weeks. The day after the final application, the skin was wiped with acetone by wiping with cotton wool, and the number of bacteria was measured from the obtained cotton wool by the agar plate method to obtain the antibacterial effect (bacterial suppression rate), and the results are shown in the table. Shown in 3. In addition, no one complained of abnormalities during the test period. As a sample, 1 mg of powder obtained by adsorbing a 5% ethanol aqueous solution of methyl parahydroxybenzoate (manufactured by Sigma) on silk fibers produced by wild silkworms obtained in Production Example 3 of the present invention was added to liquid paraffin (Wako Pure Chemical Industries, Ltd.). (Manufactured by the company) The one prepared by dispersing in 100 mg was used. As a control, 1 mg of methyl parahydroxybenzoate (manufactured by Sigma) was dispersed in 100 mg of liquid paraffin (manufactured by Wako Pure Chemical Industries, Ltd.).

【0079】

<img file="JP2003192530A_D0003.tif" />【0080】

(Test Results) As shown in Table 3, the powder obtained by adsorbing a 5% aqueous solution of methyl parahydroxybenzoate on the silk fiber produced by the wild silkworm of the present invention is stronger than the control (methyl parahydroxybenzoate only). Bacterial suppression rate was observed, and it was confirmed that it had an antibacterial effect.

【0081】

(Test 4) Moisturizing test In order to evaluate moisturization, the time course of transepidermal water loss was measured by a monitor. "Test method and evaluation method" As a monitor, apply each sample aqueous solution (1 mL) to the inside of the left and right forearms of 5 men and women in their 20s to 30s 3 times a day. After application for 1 week, stabilize in a constant temperature and humidity chamber (24 ° C, 50% RH) for 1 hour, and then use TEWAMETER TM210 (manufactured by COURAGE + KHAZAKA Electronic Gmbh) to transepidermal water loss (moisture evaporation). Amount) measurement was started. The measurement was performed at 2-second intervals for 3 minutes, and the average value of all the values was taken as the TEWL value of the test site. In addition, each blank was measured under the same conditions before application of the sample, and the results are shown in Table 4 (the lower the amount of water evaporation, the higher the moisturizing property of the skin). In addition, no one complained of abnormalities during the test period. The sample was prepared by dispersing 1 mg of a powder obtained by adsorbing a 10% aqueous solution of glycerin (manufactured by Wako Pure Chemical Industries, Ltd.) on silk fibers produced by wild silkworms obtained in Production Example 4 of the present invention in 100 mL of purified water. I used the one. As a control, a 0.1% aqueous solution of glycerin (manufactured by Wako Pure Chemical Industries, Ltd.) was used.

【0082】

<img file="JP2003192530A_D0004.tif" />【0083】

(Test Results) As shown in Table 4, the powder obtained by adsorbing a 10% aqueous solution of glycerin on the silk fiber produced by the wild silkworm of the present invention has a smaller amount of water evaporation from the skin than the control (glycerin only). confirmed. Therefore, it was found to prevent the evaporation of water related to moisturizing.

【0084】

(Test 5) Safety test (1) Primary skin irritation test Wild silk fiber powder containing various components obtained in Production Examples 1 to 4 was prepared with purified water so that the dry content concentration was about 5.0 W / V%, and the back was shaved. It was applied to the skin (female, 3 animals per group, weight around 2.3 kg). Erythema and edema were used as indicators for evaluation 24, 48, and 72 hours after application based on the Draize criteria. As a result, it was judged that no erythema and edema were observed in all the animals, and there was no problem with the primary skin irritation.

【0085】

(Test 6) Safety test (2) Cumulative skin irritation test Similarly, the wild silk fiber powder containing various components obtained in Production Examples 1 to 4 was prepared with purified water so that the dry content concentration was about 5.0 W / V%, and the back was shaved. 0.5 mL / animal was applied to the skin of guinea pigs (female, 3 animals per group, body weight around 320 g) once a day, 5 times a week. Application was performed over 2 weeks and shaving was performed on the last application day of each week. Erythema and edema were used as indicators for evaluation based on the Draize criteria on each application day and the day after the final application day. As a result, it was judged that no erythema or edema was observed in all the animals for 2 weeks, and there was no problem with the cumulative skin irritation.

【0086】

(Test 7) Safety test (3) Single-dose toxicity test The wild silk fiber powder containing various components (prepared with purified water so as to have a concentration of 12.5%) obtained in Production Examples 1 to 4 of the present invention was prepared in an amount of 16 mL / kg per animal before the test. The ddy mice (male and female, 5 animals per group, 5 weeks old) fasted for 4 hours were orally administered, and the onset and degree of toxic symptoms were observed over time. As a result, no abnormalities were observed in all the mice for 14 days, and the autopsy results were also normal. Therefore, LD₅₀Was 2,000 mg / kg or more, and was judged to be a safe substance.

【0087】

(Prescription example) Manufacture of cosmetic composition According to the above evaluation results, the formulation examples are shown below, but each formulation example may be produced by a conventional method in the production of each product, and only the blending amount is shown. Moreover, the present invention is not limited to these.

【0088】

(Prescription example 1) Emulsion mass% 1. Squalan 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Polyoxyethylene (20) soorbitan monoolate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10.A: Manufacturing example 1 B: Manufacturing example 2 C: Manufacturing example 3 D: Manufacturing example 4 * One of A to D silk fiber powder 5.0 11. Appropriate amount of fragrance 12. Residual with 100 purified water [0089]

(Prescription example 2) Emulsion mass% 1. Squalan 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Vitamin C Phosphate Magnesium Salt 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monoolate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12.1,2-Pentanediol 3.0 13. Silk fiber produced by wild silk moth (Eri or Saku silk moth) 3.0 14. Hypericum leaf or stem 70% ethanol extract 3.0 15. Silk protein enzyme decomposition solution 3.0 16. Pig placenta water extract 1.0 17. Antibacterial / preservative (paraoxybenzoic acid ester) Appropriate amount 18. Purified water Residual to be 100 [0090]

(Prescription example 3) Cosmetic oil mass% 1. Liquid paraffin 30.0 2. Squalan 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Silk fiber powder of Production Example 4 3.0 6. Clove bud hot water extract 1.0 7. Grapefruit fruit or leaf hot water extract 1.0 8. Tochu leaf hot water extract 1.0 9. Soybean seed hot water extract 1.0 10. Olive oil 1.0 11. Shea butter 1.0 12. Butylated hydroxyanisole 0.1 13. Vitamin E derivative 0.1 14. Antibacterial / preservative (benzalkonium chloride) Appropriate amount 15. Fragrance (rose water) Appropriate amount 16. Residual with 100 purified water [0091]

(Prescription example 4) Flexible lotion mass% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Silk fiber powder of Production Example 2 2.0 6. Silk fiber powder of Production Example 4 2.0 7. Blackberry Lily Root Bark or Rhizome 30% Ethanol Extract 1.0 8. Bodaiju flower or fruit 50% 1,3-butylene glycol extract 1.0 9. Yuzu fruit 30% ethanol extract 1.0 10. Grape stalk or leaf 30% ethanol extract 1.0 11. Japanese pepper peel or fruit 30% 1,2-pentanediol extract 1.0 12. Kiwifruit 50% ethanol extract 1.0 13. Antibacterial (lactoferrin solution) Appropriate amount 14. Antibacterial / preservative (paraoxybenzoic acid ester) Appropriate amount 15. Fragrance (Western Mentha) Appropriate amount 16. Residual with 100 purified water [0092]

(Prescription example 5) Convergent lotion mass% 1. Sorbitol 2.0 2. POE (20) Oleyl alcohol 1.0 3. Ethanol 15.0 4.1,2-Pentanediol 3.0 5. Silk fiber powder of Production Example 3 3.0 6. Blackberry Lily 50% 1,3-butylene glycol extract 3.0 7. Sweet William leaf 50% 1,3-butylene glycol extract 2.0 8. Gentiana whole plant 50% ethanol extract 2.0 9. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0 10. Yeast 50% 1,3-butylene glycol extract 1.0 11. Allantoin 0.2 12. Astringent (Zinc Sulfonate) 0.2 13. Antibacterial / preservative (thiamine lauryl sulfate) Appropriate amount 14. Fragrance (lavender water) Appropriate amount 15. Residual with 100 purified water [0093]

(Prescription example 6) Two-layer lotion (liquid to liquid type) Mass% 1. Squalan 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbitol 1.0 4. Ethanol 15.0 5. Silk fiber produced by wild silk moth 3.0 6. Hypericum flower or spike 50% propylene glycol extract 2.0 7. Blackberry Lily or Fruit 50% Propylene Glycol Extract 2.0 8. Rehmannia glutinosa rhizome or root bark 50% propylene glycol extract 2.0 9. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0 10. Sage whole plant 50% ethanol extract 1.0 11. Bodaiju Flower or Fruit 30% Ethanol Extract 1.0 12. Ascorbic acid 0.2 13. Astringent (calamine) 0.1 14. Antibacterial / preservative (phenoxyethanol) Appropriate amount 15. Fragrance (apple water) Appropriate amount 16. Residual with 100 purified water [0094]

(Prescription example 7) Carmine lotion (liquid to solid) Mass% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengala) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. Silk fiber produced by wild silk moth (Eri silk moth) 3.0 8. Blackberry Lily Root Bark or Rhizome 50% Propylene Glycol Extract 2.0 9. Peony root 50% propylene glycol extract 2.0 10. Cheeses flower or leaf 50% propylene glycol extract 2.0 11. Chamomile Flower 50% Propylene Glycol Extract 2.0 12. Comfrey Leaf and Stem 50% Ethanol Extract 1.0 13. Pig placenta enzymatic decomposition solution 1.0 14. Silk protein alkaline decomposition solution 2.0 15. Camphor 0.2 16. Phenol 0.03 17. Antibacterial / preservative (photoreceptor 201 &amp; 401) Appropriate amount 18. Fragrance (Bodhi tree water) Appropriate amount 19. Residual with 100 purified water [0095]

(Prescription example 8) Pack mass% 1. Polyvinyl alcohol 15.0 2. Sodium Carboxymethyl Cellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Silk fiber powder of Production Example 2 0.5 6. Blackberry Lily or Rhizome 50% Glycerin Extract 3.0 7. Hypericum flower or spike 50% glycerin extract 1.0 8. Rubus fruit 50% diglycerin extract 1.0 9. Clove bud 50% diglycerin extract 1.0 10. Citrus unshiu 50% 1,3-butylene glycol extract 1.0 11. Green tea leaf hot water extract 1.0 12. Momoba hot water extract 1.0 13. Pig placenta hot water extract 1.0 14. Antibacterial / preservative (paraoxybenzoic acid ester) Appropriate amount 15. Fragrance (rose water) Appropriate amount 16. Residual with 100 purified water [0096]

(Prescription example 9) Peel-off pack mass% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Silk fiber produced by wild silk moth (Eri silk moth) 3.0 8. Ginkgo biloba 50% glycerin extract 2.0 9. Blackberry Lily Flower or Ear 50% Glycerin Extract 2.0 10. Safflower whole plant 50% ethanol extract 2.0 11. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0 12. Eucalyptus leaf or stem 30% ethanol extract 2.0 13. Royal Jelly 50% Ethanol Extract 1.0 14. Trehalose solution 1.0 15. Antibacterial / preservative (paraoxybenzoic acid ester) Appropriate amount 16. Fragrance (chamomile water) Appropriate amount 17. Residual with 100 purified water [0097]

(Prescription example 10) Cold cream mass% 1. Beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Silk fiber powder of Production Example 1 3.0 9. Yarrow whole plant extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10. Birch bark extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 11. Panax ginseng root 50% propylene glycol extract 2.0 12. China root sclerotium 50% 1,2-butylene glycol extract 1.0 13. Soybean seed water extract 1.0 14. Liquid shea butter 1.0 15. Dipotassium glycyrrhizinate 0.1 16. Antibacterial / preservative (acrinol) 0.1 17. Fragrance (lavender water) Appropriate amount 18. Residual with 100 purified water [0098]

(Prescription example 11) Emollient cream mass% 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalan 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glycerin monostearate 2.0 8. Propylene glycol 2.0 9.1,2-pentanediol 2.0 10. Silk fiber produced by wild silk moth (Eri silk moth) 2.0 11. Silk fiber produced by wild silk moth (Muga silk moth) 2.0 12. Blackberry Lily or Rhizome 50% Propylene Glycol Extract 1.0 13. Houttuynia cordata leaf hot water extract 1.0 14. Perilla leaf 50% propylene glycol extract 2.0 15. Murasaki (purple root) root 50% propylene glycol extract 2.0 16. Soybean seed Bacillus natto fermented liquid 1.0 17. Glycyrrhetinic acid 0.1 18. Pig placenta enzymatic decomposition solution 1.0 19. Antibacterial (lactoferrin solution) 0.5 20. Antibacterial / preservative (zinc pyridion) Appropriate amount 21. Fragrance (clove water) Appropriate amount 22. Residual with 100 purified water [0099]

(Prescription example 12) Facial cleansing cream mass% 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Beef tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Silk fiber powder of Production Example 4 0.3 8. Apple fruit 20% 1,3-butylene glycol extract 2.0 9. Capillary wormwood leaf 20% 1,3-butylene glycol extract 2.0 10. Rosehip fruit 30% ethanol extract 1.0 11. Kakkonto hot water extract 2.0 12. Glycyrrhizic acid 1.0 13. Apricot kernel grain 0.1 14. Antibacterial / preservative (2-phenoxyethanol) 0.1 15. Fragrance (Angelica acutiloba ) Appropriate amount 16. Residual with 100 purified water [0100]

(Prescription example 13) Facial cleansing cream mass% 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Glycerin 18.0 6. dl-Sodium pyrrolidone carboxylate solution 1.0 7. Dioctyl adipate 1.0 8. Setostearyl alcohol 3.0 9. Triethanolamine 3.0 10. Ergocalciferol 1.0 11. Oleyl alcohol 1.5 12. Lanolin derivative (EO adduct) 1.0 13. Potassium hydroxide 6.0 14. Silk fiber produced by wild silk moth 0.1 15. Silk fiber produced by wild silkworm (Cricula) 0.1 16. Royal Jelly Extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 17. Oil-soluble chamomile flower or leaf extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 18. Oil-soluble licorice root or rhizome extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 19. Edetoate 2.0 20. Glycyrrhiretinic acid 1.0 21. Antibacterial / preservative (Photoreceptor No. 401) 0.1 22. Perfume (mugwort water) Appropriate amount 23. Residual with 100 purified water [0101]

(Prescription example 14) Body soap mass% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Alkanediol 1.0 5. Silk fiber powder of Production Example 3 1.0 6. Blackberry Lily Root Bark or Rhizome 70% 1,3-butylene Glycol Extract 1.0 7. Wakame seaweed 70% 1,3-butylene glycol extract 0.5 8. Amacha leaf or stem 70% 1,3-butylene glycol extract 0.5 9. Soybean seed Bacillus natto fermented liquid 0.5 10. Aloe pulp 70% ethanol extract 2.0 11. Polyethylene powder 0.5 12. Hydroxypropyl chitosan solution 0.5 13. Amino acids (arginine, glycine, glutamine, etc.) 0.5 14. Monoammonium glycyrrhizinate 0.1 15. Antibacterial / preservative (undecylenic acid, phenol) Appropriate amount 16. Acidity regulator Appropriate amount 17. Fragrance (lavender water) Appropriate amount 18. Purified water Residual to be 100 [0102]

(Prescription example 15) Body soap mass% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Silk fiber produced by wild silk moth (silk moth or wild silk moth) 1.0 5. Angelica acutiloba 70% 2,3-butylene glycol extract 0.5 6. Kakkonto 70% 1,3-butylene glycol extract 0.5 7. Chlorella 70% 1,3-butylene glycol extract 0.5 8. Hydrolyzed collagen solution derived from fish (salmon or flatfish) 0.5 9. Amino acids (glutamine, proline, lysine, etc.) 0.5 10. Monoammonium glycyrrhizinate 0.1 11. Antibacterial / preservative (undecylenic acid, phenoxyethanol) Appropriate amount 12. Acidity regulator Appropriate amount 13. Fragrance (orange water) Appropriate amount 14. Residual with 100 purified water [0103]

(Prescription example 16) Sunscreen cosmetics (O / W type) Mass% 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Dihydroxymethoxybenzophenone 0.2 4. Squalan 10.0 5. Vaseline 5.0 6. Stearyl alcohol 3.0 7. Stearic acid 3.0 8. Glyceryl monostearate 2.0 9. Ethyl polyacrylate 1.0 10.1,3-butylene glycol 6.0 11. Disodium edetate 0.1 12. Triethanolamine 1.0 13. Titanium dioxide 5.0 14. Silk fiber powder of Production Example 1 3.0 15. Birch bark 70% dipropylene glycol extract 1.5 16. Cornflower leaf 50% propylene glycol extract 0.5 17. Kakkonto 50% Propylene Glycol Extract 0.5 18. Yuzu fruit 50% dipropylene glycol extract 0.5 19. Antibacterial / preservative (benzyl paraoxybenzoate) Appropriate amount 20. Fragrance (jasmine water) Appropriate amount 21. Residual with 100 purified water [0104]

(Prescription example 17) Sunscreen cosmetics (oil type) Mass% 1. Liquid paraffin 70.0 2. Tetrahydroxybenzophenone 1.0 3. Cetyl octanoate 23.8 4.A: Manufacturing example 1 B: Manufacturing example 2 C: Manufacturing example 3 D: Manufacturing example 4 * One of A to D silk fiber powder 2.0 5. Chamomile flower 10% 1,3-butylene glycol extract 1.0 6. Burdock root hot water extract 0.5 7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5 8. Mallow flower or leaf 50% propyl alcohol extract 0.5 9. Coix seeds 50% 1,3-butylene glycol extract 0.5 10. Peony root or leaf hot water extract 0.5 11. Ethyl para-aminobenzoate 0.2 12. Antioxidant (butylhydroxytoluene) Appropriate amount 13. Perfume (Fennel perfume) Appropriate amount [0105]

(Prescription example 18) Cream foundation (O / W type) Mass% 1. Stearic acid 4.0 2. Glycerin monostearate 3.0 3. Cetanol 1.5 4. Isopropyl myristate 7.0 5. Liquid paraffin 10.0 6. Beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-Dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Coloring pigment (yellow iron oxide) 1.0 15. Silk fiber produced by wild silk moth (Eri silk moth or Taszár silk moth) 1.0 16. Houttuynia cordata leaf hot water extract dry powder 0.2 17. Citrus unshiu or fruit hot water extract dry powder 0.2 18. Yukinoshita whole plant hot water extract dry powder 0.2 19. Antibacterial / preservative (phenoxyethanol) 0.1 20. Fragrance (rose water) Appropriate amount 21. Residual with 100 purified water [0106]

(Prescription example 19) Shampoo mass% 1. Triethanolamine lauryl sulfate 5.0 2. Polyoxyethylene lauryl ether sodium sulfate 12.0 3.1,3-butylene glycol 4.0 4. Lauric acid diethanolamide 2.0 5. Disodium edetate 0.1 6. Silk fiber produced by wild silk moth (silk moth or wild silk moth) 2.0 7. Hypericum whole plant 20% 2,3-butylene glycol extract 2.0 8. Blackberry Lily Root Bark or Rhizome Hot Water Extract 2.0 9. Iris flower or rhizome 30% 1,4-butylene glycol extract 2.0 10. Angelica acutiloba 30% 1,4-butylene glycol extract 2.0 11. Hydroxypropyl chitosan solution 1.0 12. Hyaluronic acid solution 1.0 13. Dipotassium glycyrrhizinate 0.1 14. Antibacterial / preservative (Photoreceptor No. 101) Appropriate amount 15. Acidity regulator Appropriate amount 16. Fragrance (sandalwood water) Appropriate amount 17. Purified water [0107]

(Prescription example 20) Rinse mass% 1. Stearyltrimethylammonium chloride 3.0 2. Setostearyl alcohol 3.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5.1,2-Pentanediol 2.0 6. Silk fiber produced by wild silk moth (silk moth or wild silk moth) 3.0 7. Calendula officinalis flower 50% 1,3-butylene glycol extract 1.0 8. Astragalus leaf 50% 2,3-butylene glycol extract 1.0 9. Fennel fruit 30% 1,2-butylene glycol extract 1.0 10. Coptis chinensis 50% 1,3-butylene glycol extract 1.0 11. Comfrey Leaf or Stem 50% 1,3-butylene Glycol Extract 1.0 12. Soybean seed Bacillus natto fermented liquid 0.5 13. Hydroxyethyl chitosan solution 0.5 14. Fish (salmon or tuna) -derived hydrolyzed collagen solution 0.5 15. Trehalose solution 0.5 16. Hydrolyzed silk solution 0.5 17. Antibacterial / preservative (benzalkonium chloride) Appropriate amount 18. Fragrance (grape water) Appropriate amount 19. Residual with 100 purified water [0108]

(Prescription example 21) Rinse mass% 1. Stearyltrimethylammonium chloride 2.0 2. Setostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Silk fiber produced by wild silk moth (Taszár silk moth or Anafé) 3.0 7. Blackberry leaf or stem 50% 1,3-butylene glycol extract 3.0 8. Tilia or fruit 50% 1,4-butylene glycol extract 1.0 9. Olive leaf 50% 1,2-butylene glycol extract 1.0 10. Loquat leaf 50% ethanol extract 1.0 11. Mukuge fruit or flower 50% 1,3-butylene glycol extract 1.0 12. Trehalos solution 1.0 13. Hydrolyzed keratin solution 1.0 14. Antibacterial / preservative (benzalkonium chloride) Appropriate amount 15. Fragrance (chamomile water) Appropriate amount 16. Residual with 100 purified water [0109]

(Prescription example 22) Hair liquid mass% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Silk fiber produced by wild silk moth (Tasar silk moth or Cricula) 3.0 6. Tormentilla root or rhizome 50% 1,3-butylene glycol extract 1.0 7. Hop female spike 50% ethanol extract 1.0 8. Melissa whole plant 50% ethanol extract 1.0 9. Wild ginger rhizome 30% ethanol extract 1.0 10. Birch sap 1.0 11. Carpronium chloride 0.3 12. Hinokitiol 0.5 13. Keratin decomposition solution 0.5 14. Stearyl glycyrrhetinate 0.1 15. Antibacterial / preservative (paraben, benzalkonium chloride) Appropriate amount 16. Fragrance (rosehip water) Appropriate amount 17. Residual with 100 purified water [0110]

(Prescription example 23) Hair liquid mass% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5.1,2-Hexanediol 1.0 6. Swertia japonica leaf or stem 50% 1,2-butylene glycol extract 3.0 7. Panax ginseng root hot water extract 3.0 8. Lemongrass leaf 50% 1,3-butylene glycol extract 1.0 9. Apple fruit 30% ethanol extract 1.0 10. Sesamolin 0.3 11. Silk fiber produced by wild silk moth (Tasar silk moth or Anafé) 0.5 12. Azulene 1.0 13. Antibacterial / preservative (paraben, benzalkonium chloride) Appropriate amount 14. Fragrance (orange water) Appropriate amount 15. Residual with 100 purified water [0111]

(Prescription example 24) Hair liquid mass% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hardened castor oil 2.0 4. Silk fiber produced by wild silk moth (Eri silk moth or Anafé) 0.3 5. Comfrey leaf or stem 50% ethanol extract 3.0 6. Yuzu leaf or fruit 50% ethanol extract 3.0 7. Soybean seed Bacillus natto fermented liquid 2.0 8. Hamamelis leaf or bark hot water extract 2.0 9. Comfrey leaf or stem 50% ethanol extract 2.0 10. Loquat leaf 30% ethanol extract 2.0 11. Carpronium chloride 0.3 12. Pantothenic acid aqueous solution 0.3 13. Amino acids or their derivatives 3.0 (Lysine, alanine, pyrrolidone carboxylic acid, etc.) 14. Antibacterial / preservative (paraben, benzalkonium chloride) Appropriate amount 15. Fragrance (rose water) Appropriate amount 16. Residual with 100 purified water [0112]

(Prescription example 25) Hair tonic mass% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hardened castor oil 2.0 4. Silk fiber produced by wild silk moth (Eri silk moth or Taszár silk moth) 1.0 5. Clove leaf 30% ethanol extract 2.0 6. Antibacterial / preservative (propyl paraoxybenzoate) 0.2 7. Residual with 100 purified water [0113]

(Prescription example 26) Hair tonic mass% 1. l-menthol 0.2 2. Ethanol 32.5 3. Polyoxyethylene hydrogenated castor oil 0.5 4. Propylene glycol 5.0 5. Diphenhydramine hydrochloride 0.3 6.A: Manufacturing example 1 B: Manufacturing example 2 C: Manufacturing example 3 D: Manufacturing example 4 * One of A to D silk fiber powder 2.0 7. Otogirisou fruit or peel hot water extract 3.0 8. Lavender flower or spike hot water extract 1.0 9. Below oil rhizome or root bark 50% ethanol extract 1.0 10. Scutellaria rhizome or root bark 50% ethanol extract 1.0 11. Soybean seed hot water extract 1.0 12. Carboxymethyl chitin solution 1.0 13. Comb extract 0.2 14. Pantothenic acid aqueous solution 0.2 15. Antibacterial / preservative (phenoxyethanol) Appropriate amount 16. Fragrance (sage water) Appropriate amount 17. Purified water Residual to be 100 [0114]

(Prescription example 27) Hair restorer / hair restorer Mass% 1. Ethanol 60.0 2. Blackberry Lily 50% Glycerin Extract 5.0 3. Tachijakousou whole plant 50% propylene glycol extract 2.0 4. Vitamin E derivative 0.5 5. Silk fiber produced by wild silk moth (Eri or Saku silk moth) 1.0 6. Togarashi tinki 0.5 7. Resorcin 0.5 8. Dipotassium glycyrrhizinate 0.5 9. Carboxymethyl chitin solution 0.5 10. Collagen protein enzyme decomposition solution 2.0 11. Pork hematin solution 0.5 12. Pork mucin solution 0.5 13. Amino acids (arginine, glycine, glutamine, etc.) 0.5 14. Antibacterial / preservative (paraben) 0.1 15. Fragrance (rosemary water) Appropriate amount 16. Residual with 100 purified water [0115]

(Prescription example 28) Hair restorer / hair restorer Mass% 1. Ethanol 60.0 2. Blackberry Lily Root Bark or Rhizome Hot Water Extract 3.0 3. Swertia japonica 60% ethanol extract 3.0 4. Peony rhizome or root bark 60% ethanol extract 3.0 5. Mugwort leaf or stem 50% 1,3-butylene glycol extract 1.0 6. Soybean seed Bacillus natto fermented liquid 1.0 7. Silk fiber produced by wild silk moth (Eri or Muga silk moth) 1.0 8. Cantalis tincture 0.5 9. Pantothenic acid derivative 0.2 10.β-Glycyrrhetinic acid 0.2 11. Resorcin 0.2 12. Hydroxyethyl chitosan solution 0.2 13. Elastin Hydrolyze 0.2 14. Keratin protein enzymatic degradation solution 0.2 15. Preservative (paraben) 0.1 16. Fragrance (lavender water) Appropriate amount 17. Residual with 100 purified water [0116]

(Prescription example 29) Granule bath agent Mass% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 6.0 4. Silk fiber produced by wild silk moth (Eri silk moth or Clicula) 3.0 5. Sorbitol 2.0 6. Peach leaf 70% ethanol extract dry powder 1.0 7. Dye (Gunjo Green) Appropriate amount [0117]

(Prescription example 30) Granule bath agent Mass% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Silk fiber produced by wild silk moth (silk moth or wild silk moth) 3.0 5. Hyaluronic acid powder 3.0 6. Elderberry flower or berry hot water extract dry powder 1.0 7. Apple juice powder 1.0 8. Dye (Gunjo, Chromium Hydroxide) Appropriate amount 9. Fragrance (grape water) Appropriate amount [0118]

(Prescription example 31) Coating protective agent A gauze or liniment cloth is impregnated with a prescription solution containing an appropriate amount of a silk fiber ethanol solution produced by wild silk moth (Ery silk moth or Clicula), an antibiotic, an anti-inflammatory agent, etc. Alternatively, a silk fiber ethanol solution produced by wild silk moth (Ery silk moth or Clicula) may be directly and locally sprayed and coated with gauze or the like.

【0119】

(Prescription example 32) Toothpaste weight% 1. Silica anhydride 20.0 2. Sorbitol liquid 50.0 3. Glycerin 10.0 4. Silk fiber produced by wild silk moth (Eri silk moth or Taszár silk moth) 5.0 5. Sodium lauryl sulfate 2.0 6. Saccharin sodium 0.05 7. Sodium Carboxymethyl Cellulose 1.5 8. Fragrance Appropriate amount 9. Appropriate amount of colorant 10. Appropriate amount of purified water [0120]

(Prescription example 33) Mouth refreshing agent mass% 1. Ethanol 20.0 2. Glycerin 15.0 3. Polyoxyethylene hydrogenated castor oil 1.0 4. Saccharin 0.2 5. Chlorohexidine 0.01 6. Hypericum leaf or stem hot water extract dry powder 0.1 7. Silk fiber produced by wild silk moth (Eri silk moth or Clicula) 0.1 8. Green tea leaf hot water extract dry powder 0.1 9. Dye (Gunjo Green) Appropriate amount 10. Residual with 100 purified water [0121]

(Prescription example 34) Dishwashing detergent Mass% 1. Alkyl (C12) glucoside 20.0 2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0 3. Glycerin 2.0 4. Ethanol 5.0 5. Blackberry root bark hot water extract dry powder 1.5 6. Silk fiber produced by wild silk moth (Eri or Saku silk moth) 3.0 7. Rubus peel or fruit hot water extract dry powder 2.0 8. Residual with 100 purified water [0122]

(Test 8) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The usage test is conducted with 10 panelists each of women aged 20 to 40 who suffer from dry skin, dull skin, or spots, freckles, and dark skin, and prescribe it twice daily, morning and evening, after washing their face. An appropriate amount of the emulsion of Example 1 was applied to the face for 3 months. As a control, a milky lotion obtained by removing the product of the present invention was formulated by the same method. The evaluation method is based on the following criteria, and the results are shown in Tables 5 to 6, and the numerical values in the table indicate the number of people. No one complained of skin abnormalities during the period of use.

【0123】

"Skin feel improvement effect" Effective: Increased dry skin and skin gloss and tension, and improved skin. Slightly effective: Dry skin, slightly increased gloss and tension, and slightly improved skin. No effect: No change from before use.

【0124】

"Blemish, freckles &amp; skin color improvement effect" Effective: Spots, freckles and skin color were white and alleviated. Slightly effective: White spots, freckles and skin color were slightly reduced. No effect: No change from before use.

【0125】

<img file="JP2003192530A_D0005.tif" />【0126】

<img file="JP2003192530A_D0006.tif" />【0127】

(Test Results) As shown in Tables 5 to 6, a cosmetic composition containing silk fibers produced from the wild silkworms of the present invention and one or more of a whitening agent, an antioxidant, an antibacterial agent, and a moisturizer It was confirmed that it significantly improved dry skin, gave gloss and tension to the skin, improved spots and freckles, and reduced skin color to white.

【0128】

[Effect of the invention]

A cosmetic composition containing a silk fiber produced from a wild silkworm of the present invention in combination with any one or more of a whitening agent, an antioxidant, an antibacterial agent, and a moisturizer has an excellent whitening effect and antioxidant effect. It has an effect, an antibacterial effect, and a moisturizing effect, and can significantly improve dry skin, give gloss and tension to the skin, improve stains and buckwheat, and reduce the color of the skin white. Therefore, it is effective in preventing skin aging and can be applied to all forms of preparations (pharmaceuticals, quasi-drugs, cosmetics). It is safe for humans and animals, and can also be used for general food and drink.