Packaging body

Description: TECHNICAL FIELD [Detailed description of the invention]

【0001】

[Technical field to which the invention belongs]

The present invention relates to a packaging body that wraps an instrument such as a catheter.

【0002】

[Conventional technology]

The surface of medical instruments such as the trachea, gastrointestinal tract, urethra, blood vessels, other body cavities, catheters inserted into various organs, living tissues, etc., and guide wires inserted into the catheters are generally clots, tissue adhesion, or Many foreign body reactions are confirmed. Therefore, it is necessary to reduce the damage to the living tissue and to surely insert it into the target site. In addition, it is necessary to provide lubricity to the surface of the instrument in order to suppress mucosal inflammation and mucosal damage during placement in living tissues.

【0003】

For this reason, a low-friction material is used as a base material, or water, a physiological isotonic solution, or a lubricant is applied to the surface of the device prior to use. More specifically, the base material of the catheter has a multi-layered laminated structure, and a low friction material such as fluororesin or polyethylene resin is used for the outermost layer (or innermost layer) of the base material, or water, a physiological isotonic solution, or glycerin is used on the surface of the device. , Oil or other lubricants are applied.

【0004】

However, in selecting the material of the catheter base material, there is a limit to the improvement of slidability, and it is difficult to reach a satisfactory level.

【0005】

In addition, when a lubricant or the like is applied, if it is attempted to commercialize the product in contact with the medical device, the lubricant will deteriorate or deteriorate during a long period of time until the medical device is used. In addition, there are concerns about peeling from the surface of medical instruments, and there are problems in terms of stability (preservation) and safety associated therewith.

【0006】

Further, it is very difficult to aseptically contact the medical instrument and the lubricant at the time of use, and there is a problem that there is a risk of bacterial infection or the like.

【0007】

In addition, in an emergency, maintaining the life of the patient is the highest priority, so the work of applying the lubricant becomes troublesome, and in some cases, the surface is used in a dry state without applying the lubricant. There are times.

【0008】

As a method for allowing a compound that exhibits lubricity when wetted on the surface of a medical device to be present, the international application WO9001344 states that the surface of a polyurethane is coated with an alkali metal alcoholate, an amino group, an alkali metal amide group, a carboxylic acid group, or a sulfone. A technique has been disclosed in which at least one of an acid group, a magnesium halide group and a fluoroboron-based complex group is introduced, and a hydrophilic polymer capable of reacting with these functional groups is immobilized on the surface by a coating operation.

【0009】

Similarly, methods for allowing a compound that exhibits lubricity when wetted on the surface of a medical device are described in JP-A-6-32652, Japanese Patent Application Laid-Open No. 6-7426, International Application WO9219289, and Japanese Patent Application Laid-Open No. 10-502854. , Special Table No. 10-502855, Special Table No. 10-502856, etc.

【0010】

However, in these methods, lubricity is not exhibited by drying, and at the time of use, the medical device is taken out from the packaging material, and a liquid such as water or a physiological isotonic solution is supplied to the surface of the medical device. The operation of contact is essential. Moreover, it was very difficult to perform this operation aseptically except when using a special operation or facility. Therefore, as mentioned above, there is a risk of infection, and in an emergency, the surface may be directly inserted into the trachea, digestive tract, urethra, blood vessels, etc. while the surface is dry, and there is concern about damage to the mucous membranes, etc. It was to be done.

【0011】

On the other hand, when blood comes into contact with a foreign substance other than vascular endothelial cells, plasma protein, platelet adhesion, and blood coagulation are induced on the surface of the foreign substance, and a thrombus is formed. This thrombus formation becomes a problem when using medical instruments such as catheters and guide wires.

【0012】

Therefore, a blood anticoagulant such as heparin is administered into the blood, a blood anticoagulant or the like is applied to the surface of a medical device, or an antithrombotic material is used as a base material. ..

【0013】

However, in the former case, the patient has an adverse effect such as bleeding tendency, and in the latter case, a contact operation with a liquid is required at the time of use, and it is very difficult to perform this operation aseptically. It is similar to the above in that it is difficult.

【0014】

Furthermore, in an emergency, maintaining the life of the patient is the highest priority, so it may be used directly without anticoagulant operation, and there is concern about the harmful effects of thrombus formation.

【0015】

In addition, after using these medical devices, they are disposed of as medical waste, but usually, they are not inactivated (disinfected / sterilized) or deodorized for bacteria and viruses in body fluids and blood. , Was discarded while remaining infectious or allowing the release of odors.

【0016】

Therefore, after the use of the medical device and before it is incinerated, the odor may be dissipated or body fluids such as urine and blood may leak out, causing contamination and infection of the surroundings.

【0017】

[Problems to be Solved by the Invention]

The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to enable simple and aseptic contact between an instrument and a liquid, and to dissipate odor to the outside after the instrument is used. The purpose is to provide a package that can prevent contamination, infection, etc.

【0018】

[Means for solving problems]

Such an object is achieved by the present invention of the following (1) to (15).

【0019】

(1) A packaging material having a first space and a second space that are separated from each other by a partition and can communicate with each other when necessary, and an instrument that is stored in the first space and inserted or attached to a living body. And a substance stored in the first space to eliminate or reduce the odor, and a fluid substance stored in the second space and capable of contacting the surface of the device to reduce its frictional resistance. A packaging body characterized by being provided with.

【0020】

(2) The package according to (1) above, wherein the main component of the substance that eliminates or reduces the odor is titanium oxide.

【0021】

(3) A packaging material having a first space and a second space that are separated from each other by a partition and can communicate with each other when necessary, and an instrument that is stored in the first space and inserted or attached to a living body. A substance that is stored in the first space and has a function of suppressing the growth of microorganisms at least, and a substance that is stored in the second space and can come into contact with the surface of the device to reduce its frictional resistance. A packaging body comprising a fluid substance.

【0022】

(4) The package according to (3) above, wherein the main component of the substance having a function of suppressing the growth of the microorganism is titanium oxide.

【0023】

(5) A packaging material having a first space, a second space, and a third space that are separated from each other by a partition and can communicate with each other when necessary, and a packaging material that is stored in the first space and inserted or attached to a living body. A fluid substance that is stored in the second space and can contact the surface of the device to reduce its frictional resistance, and a fluid substance that is stored in the third space and absorbs a liquid. A packaging body comprising, with a substance that can be retained.

【0024】

(6) A packaging material having a first space, a second space, and a third space that are separated from each other by a partition and can communicate with each other when necessary, and a packaging material that is stored in the first space and inserted or attached to a living body. A packaging body comprising the device used, a blood anticoagulant stored in the second space, and a substance stored in the third space and capable of absorbing and holding a liquid.

【0025】

(7) The first space and the second space are formed adjacent to each other, and the first space and the third space are formed adjacent to each other (5) or (. The packaging described in 6).

【0026】

(8) The package according to any one of (1) to (7) above, wherein the second space is formed inside the first space.

【0027】

(9) The packaging body according to any one of (1) to (8) above, wherein the partition portion is composed of a sealing portion formed by fusing the sheet material constituting the packaging material.

【0028】

(10) The package according to any one of (1) to (9) above, wherein at least a part of the partition portion is composed of a weak seal portion having a weaker joint strength than the other portion.

【0029】

(11) Any of the above (1) to (10) having an opening portion for taking out the device from the first space and a sealing means for sealing the opening after opening the opening portion. The packaging described in.

【0030】

(12) The package according to any one of (1) to (11) above, wherein the packaging material has a water vapor barrier property.

【0031】

(13) The package according to any one of (1) to (12) above, wherein the device is a catheter or a guide wire.

【0032】

(14) The package according to any one of (1) to (12) above, wherein the device is a catheter used by being inserted into the urethra.

【0033】

(15) The package according to any one of (1) to (14) above, wherein a compound that exhibits lubricity by wetting is applied to the surface of at least a part of the device.

【0034】

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the package of the present invention will be described in detail based on the preferred examples shown in the accompanying drawings.

【0035】

FIG. 1 is a plan view (internal perspective view) showing a first embodiment of the package of the present invention. As shown in the figure, the packaging body 1 has a packaging material 2 having a first space and a second space.

【0036】

The packaging material 2 is formed by sealing a sheet material as described later into a desired pattern by fusion (or adhesion) to form a bag. A band-shaped seal portion 21 is formed on the outer peripheral portion of the packaging material 2 and the like.

【0037】

Further, a partition portion 22 is formed in the middle of the packaging material 2. The partition portion 22 is formed by fusing (or adhering) a sheet material in a strip shape in the same manner as the sealing portion 21. The partition portion 22 divides the inside of the packaging material 2 into a first space 4 and a second space 5 which are independent (isolated from each other).

【0038】

As shown by diagonal lines in FIG. 1, a part of the partition portion 22 is composed of a weak seal portion (easy peel seal portion) 23 having a weaker joint strength (peeling strength) than the other portion (seal portion 21). There is. By peeling (breaking) the weak seal portion 23, the first space 4 and the second space 5 communicate with each other.

【0039】

The sealing portion 21 is in a strong bonded state in which the opposing sheet materials are completely fused to each other, whereas the weak sealing portion 23 is fused to the opposing sheet materials due to fusion at a lower temperature or the like. It is said that the clothes are incomplete to some extent. However, the liquidtightness (airtightness) is ensured even in the weak seal portion 23. And the effect lasts over time.

【0040】

The weak seal portion 23 can be peeled (broken) by pressing (compressing) the portion of the packaging material 2 that defines the second space 5 and increasing the internal pressure of the second space 5. In addition, the weak seal portion 23 may be kneaded and loosened by hand, and these methods may be used in combination. In this way, the first space 4 and the second space 5 can be communicated with each other with an extremely simple operation.

【0041】

The weak seal portion 23 may be formed at two or more locations of the partition portion 22, or may be formed over almost the entire partition portion 22.

【0042】

Further, a weak seal portion (opening portion) 24 similar to the weak seal portion 23 is also formed in the seal portion 21 at the upper end portion in FIG. 1 of the packaging material 2. The weak seal portion 24 can be peeled (broken) to open the packaging material 2, and the stored items in the first space 4 can be taken in and out.

【0043】

Further, a zipper (sealing means) 3 that can be opened and closed is provided in the vicinity of the upper end side of FIG. 1 of the weak seal portion 24. Even after the weak seal portion 24 is peeled (broken) and the packaging material 2 is opened, the opening can be sealed by closing the zipper 3. Also, if the zipper 3 is opened, the opening can be opened again.

【0044】

As the zipper 3, any known zipper 3 can be used, for example, one having a groove and a ridge that are fitted to each other.

【0045】

The first space 4 contains an instrument that is inserted or attached to a living body and used, and a substance that eliminates or reduces odor. A catheter or a guide wire is preferable as an instrument to be inserted or attached to a living body, and in this embodiment, a catheter 7 and a deodorant (deodorant) 8 are housed in the first space 4. There is.

【0046】

The catheter 7 includes various types of catheters 7 that are inserted into, for example, the trachea, digestive tract, urethra, vagina, blood vessels, lymph vessels, bile ducts, other body cavities, various organs such as lungs, hearts, kidneys, and other biological tissues. Examples thereof include a catheter and a balloon catheter, and a catheter (urethral catheter, urethral catheter) used by being inserted into the urethra is particularly preferable.

【0047】

As the urinary catheterization method for dysuria, a sterile intermittent catheterization method is preferable to an indwelling catheter, but in recent years, self-catheterization in which the patient himself / herself discharges urine using a catheter has become widespread as an effective treatment method. Dysuria is caused by urethral obstruction due to benign prostatic hyperplasia, stones, tumors, and neurogenic bladder caused by disorders of the brain, spinal cord, and pelvic nerves. It is necessary to drain urine regularly because the internal pressure rises and puts a strain on the kidneys. The self-cathetering method performed at this time has advantages such as reduction of existing urine infection, cure of pollakiuria and urinary incontinence, and no burden on the bladder and kidneys because urine can be completely discharged at low pressure. , The patient himself inserts a catheter into the bladder from the urethra about 4 to 6 times a day, and removes it when urine is completely discharged. The frequency is, for example, every 4 to 5 hours during the day and before bedtime at night.

【0048】

It is preferable that the surface of the catheter 7 is provided with, for example, a substance that exhibits lubricity by wetting. Examples of such a substance include hydrophilic polymers as described in JP-A-60-259269 and JP-A-1-195863. In addition, for example, Japanese Patent Application Laid-Open No. 6-32652, Japanese Patent Application Laid-Open No. 6-7426, International Application WO8802623, International Application WO8907521, International Application WO8909246, International Application WO9001344, International Application WO9219289, International Application WO9311751, International Application WO9529722, Special Table 10 The substances and methods disclosed in -502854, Special Table 10-502855, and Special Table 10-502856 may be used. Such a substance is present on the surface of the catheter 7 in a non-wet state (dry state).

【0049】

Such a substance is a polymer chemically bonded to the surface of the base material of the catheter 7, and peeling from the surface of the base material of the catheter 7 is unlikely to cause elution into water, a physiological isotonic solution, other lubricants, or the like. Those are preferable from the viewpoint of sustainability of lubricity and safety.

【0050】

As the deodorant (deodorant) 8, any commercially available deodorant, deodorant, fragrance, or the like may be used. In this case, even in the odor removal mechanism of the deodorant 8, the physical deodorant method (porous substances such as activated charcoal and zeolite) and the chemical deodorant method (various organic / inorganic compounds, plant extracts, ozone, noble metal-based oxidation). (Catalyst), biological deodorant method (microorganism, artificial enzyme), sensory deodorant method (aromatic compound, vegetable oil), etc., as long as they can be stored in the first space 4.

【0051】

Titanium oxide (TiO) is particularly preferable as the deodorant 8.₂). This titanium oxide has the following advantages.

【0052】

1) It is a harmless inorganic oxide and can be harmonized with the environment. 2) As a result of ultraviolet light excitation, it has a strong oxidizing power and can decompose the adsorbed organic matter at room temperature. 3) The adsorbed oxygen is changed to oxygen radicals, and the adsorbed organic substances can be decomposed at room temperature by these radicals. 4) The effects of 2) and 3) above are evoked by the illumination light of the daily living space.

【0053】

Due to such excellent functions of titanium oxide, not only a deodorizing effect but also an antibacterial and antifungal effect can be obtained. Such titanium oxide is preferably supported on a base material of an organic synthetic fiber such as paper or non-woven fabric or a fiber composed of an organic compound such as pulp.

【0054】

Such a deodorant 8 is stored in a breathable container (packaging material) 81. The container 81 is preferably made of a material that allows gas to permeate but not liquid to permeate. Examples of the constituent material of such a container 81 include a water-impermeable porous body such as a polyethylene non-woven fabric and a polytetrafluoroethylene porous body.

【0055】

The second space 5 contains (fills) a fluid substance (liquid or semi-liquid substance) 10 that can come into contact with the surface of the catheter 7 and reduce its frictional resistance.

【0056】

Examples of the fluid substance 10 include water, physiological isotonic solution (saline), glycerin, silicone oil, olive oil and other oils, xylocaine jelly and the like (hereinafter, these are collectively referred to as "lubricant"). Say).

【0057】

When the surface of the catheter 7 is provided with a substance that exhibits lubricity by wetting as described above, the fluid substance 10 may be any substance that can moisten this substance, and a typical example thereof. As, water, a physiological isotonic solution (physiological saline solution), a glycerin aqueous solution, or the like is selected.

【0058】

The packaging material 2 (preferably the entire packaging material 2) preferably has a water vapor barrier property. Here, the water vapor barrier property means that the water vapor permeability is preferably 30 g / m.² 24hrs 25μm thickness 40 ° C 90% RH or less, more preferably 10g / m² 24hrs 25μm thickness 40 ° C 90% RH or less, more preferably 1g / m² 24hrs 25μm thickness 40 ° C 90% RH or less. This water vapor permeability is measured by the method described in JIS K 7129 (Method A).

【0059】

Since the packaging material 2 has a water vapor barrier property in this way, it is possible to prevent the evaporation of water from the inside of the packaging material 2, particularly from the second space 5. As a result, it is possible to prevent a decrease and concentration of the liquid agent (fluid substance 10, etc.) in the second space 5, and the amount of the liquid agent can be the minimum necessary amount, and the volume of the entire package 1 and the volume of the package 1 can be increased. The weight can be reduced. In addition, it is possible to prevent water vapor from entering the outside of the packaging material 2 and the first space 4 from the second space 5.

【0060】

Examples of the sheet material (film) constituting the packaging material 2, particularly the sheet material having the water vapor barrier property, include polyolefin resins such as polyethylene and polypropylene, blend resins of these polyolefin resins, polyester resins such as polyethylene terephthalate, and polyvinylidene chloride. Single-layer films such as vinylidene and vinylidene chloride-vinylidene chloride copolymers, those obtained by depositing aluminum, silica, etc. on these films, and metal foils such as aluminum films and aluminum laminate films, or films containing metal foils can be used. it can. Further, a film obtained by laminating two or more layers of each of these films can also be used.

【0061】

In the weakly sealed portions 23 and 24, a blend resin of two or more types of polyolefin resins in which the layers (sealant layers) directly involved in the direct fusion are incompatible with each other, or two or more types of polyolefins incompatible with each other are used as segments. It is preferably composed of a random or block copolymer having.

【0062】

In the present invention, it is preferable that the entire packaging material 2 or the portion of the packaging material 2 that defines at least the second space 5 is made of a sheet material having a water vapor barrier property. Such sheet materials include, for example, [1] a single-layer film composed of one type of polyolefin resin, [2] a single-layer film composed of two or more types of incompatible polyolefin resin blend resins, [2] 3] Examples thereof include a polyolefin resin or a polyester resin multilayer film using a polyolefin resin (a blended resin of a polyolefin resin can also be used) for the sealant layer (layer involved in fusion).

【0063】

To obtain higher steam barrier properties, for example, [4] a film in which the sealant layer is made of a polyolefin resin (a blended resin of a polyolefin resin can also be used), a polyolefin or polyester film in which the outer layer is coated with polyvinylidene chloride, or the like. Multilayer film composed of [5] film whose sealant layer is composed of polyolefin resin (blend resin of polyolefin resin can also be used), multilayer film whose outer layer is aluminum-deposited or silica-deposited polyolefin film or polyester film, etc. Film, for example.

【0064】

Further, in order to obtain extremely high water vapor barrier property, for example, [6] a film in which the sealant layer is made of a polyolefin resin (a blend resin of a polyolefin resin can also be used), an intermediate layer is an aluminum film, an outermost layer is a polyester film, or the like. A multilayer film composed of. In this case, if one of the pair of facing sheet materials is an opaque aluminum film and the other is a transparent water vapor barrier film such as a silica-deposited film, the contents of the packaging material 2 can be visually confirmed. More preferred. The aluminum film may be partially or completely peelable and removable, if necessary.

【0065】

The thickness of the sheet material (single-layer or multi-layer laminate) constituting the packaging material 2 is appropriately determined according to the layer structure and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.). Although not particularly limited, it is usually preferably about 60 to 700 μm, and more preferably about 100 to 500 μm.

【0066】

The sheet material constituting such packaging material 2 includes, for example, an inflation method, a T-die method, a blow molding method, a dry laminating method, a hot melt laminating method, a coextrusion inflation method, a coextrusion T die method, a hot press method, and the like. It can be produced by various methods of.

【0067】

Next, the second embodiment of the package of the present invention will be described focusing on the differences from the first embodiment, and the description of the same matters will be omitted.

【0068】

The package of the second embodiment contains a substance having at least a function of suppressing the growth (propagation) of microorganisms (bacteria, viruses, etc.) in place of the deodorant 8 in the package 1 shown in FIG. .. A typical example of this substance is an antibacterial agent, and the antibacterial agent will be described below. Here, the antibacterial agent is a general term for substances having bactericidal, disinfecting, sterilizing, antibacterial or antibacterial effects.

【0069】

The antibacterial agent may be either an organic antibacterial agent or an inorganic antibacterial agent, but in terms of placing more importance on safety such as prevention of the emergence of resistant bacteria, for example, metals, metal oxides, various ceramics and the like Inorganic antibacterial agents are preferred.

【0070】

In addition, antibacterial agents can be classified into cell wall synthesis inhibition, cell membrane disorder, protein synthesis inhibition, DNA synthesis disorder, intracellular metabolism disorder and the like according to their mechanism of action, but in the present invention, any action mechanism may be used.

【0071】

Particularly preferred such antibacterial agents are the aforementioned titanium oxide (TiO).₂). This titanium oxide is as described above.

【0072】

Further, the antibacterial agent is stored in a container (packaging material) having breathability and liquid permeability composed of, for example, a woven fabric, a mesh (mesh), or the above-mentioned container (packaging material) 81. , It is preferable that it is stored in the first space 4.

【0073】

FIG. 2 is a plan view (internal perspective view) showing a third embodiment of the package of the present invention. Hereinafter, the packaging body of the third embodiment will be described mainly on the differences from the first embodiment, and the description of the same items will be omitted.

【0074】

As shown in FIG. 2, the package 1 of the third embodiment is a sheet-shaped antibacterial agent as an antibacterial agent (at least a substance having a function of suppressing the growth of microorganisms) in the first space 4 of the packaging material 2. That is, the antibacterial sheet 9 is stored.

【0075】

Examples of the antibacterial sheet 9 include those in which an organic antibacterial agent, a metal having antibacterial activity such as silver, copper and zinc, and an antibacterial agent such as ceramics are supported on a base material such as a sheet or a porous body. .. Inorganic antibacterial agents, which are less likely to cause the emergence of resistant bacteria, are particularly preferable.

【0076】

In the illustrated configuration, the antibacterial sheet 9 is arranged in a part of the first space 4, but an antibacterial sheet having a size that covers almost the entire area of the first space 4 can also be used. Further, a plurality of antibacterial sheets 9 may be stored.

【0077】

By storing the antibacterial agent in the first space 4 as in the second and third examples, not only the catheter 7 before or after opening the packaging material 2 but also the used catheter 7 can be used. Even when it is returned to the space 4 of 1, it can exert an antibacterial effect on the catheter 7, and it is possible to carry out transportation and disposal until disposal in a hygienic and safe manner.

【0078】

FIG. 3 is a plan view (internal perspective view) showing a fourth embodiment of the package of the present invention. Hereinafter, the packaging body of the fourth embodiment will be described mainly on the differences from the first embodiment, and the description of the same items will be omitted.

【0079】

As shown in FIG. 3, in the package 1 of the fourth embodiment, the second space 5 is formed inside the first space 4. That is, the packaging material 2 has a first space 4, in which the above-mentioned catheter 7, the deodorant 8 (or antibacterial agent), and the packaging material (bag body) 11 are housed. ..

【0080】

The small packaging material 11 is formed by stacking sheet materials similar to the sheet materials constituting the packaging material 2 described above and sealing the outer peripheral portion thereof by fusion (or adhesion) to form a bag shape. A second space 5 is formed. The above-mentioned fluid substance 10 is stored (filled) in the second space 5.

【0081】

The seal portion on the outer periphery of the packaging material 11 constitutes a partition portion 22 that separates the second space 5 and the first space 4. A weak seal portion 23 similar to the above is formed in a part of the partition portion 22. By peeling (breaking) the weakly sealed portion 23, the first space 4 and the second space 5 communicate with each other, and the fluid substance 10 can flow into the first space 4.

【0082】

The package 1 having such a configuration has the following effects (advantages). First, by selecting the capacity of the packaging material 11 to be put in the first space 4, the amount and weight of the contents (fluid substance 10 and the like) of the packaging material 11 can be easily set. Secondly, since the parcel material 11 can move in the first space 4, the operation of peeling (breaking) the weak seal portion 23 and the operation of squeezing the fluid substance 10 etc. from the parcel material 11 after that are performed. It can be done easily. Thirdly, since it is a double package, the level of water vapor barrier property required for the packaging material 11 which is a container for the fluid substance 10 may be lower than that in the first to third embodiments. , The degree of freedom in selecting the constituent material of the packaging material 11 is widened, and the sheet thickness can be made thinner, which is advantageous in manufacturing. Fourth, since the parcel material 11 can be manufactured independently, it is easy to manufacture and manage.

【0083】

In the case of the package 1 of the fourth embodiment, only the packaging material 11 may have a water vapor barrier property.

【0084】

Next, the usage (action) of each of the above-mentioned packaging bodies 1 will be described.

【0085】

For example, when the weak seal portion 23 is peeled (broken) by the method as described above, the first space 4 and the second space 5 communicate with each other, and the fluid substance 10 stored in the second space 5 is released. It flows into the first space 4 and comes into contact with the surface of the catheter 7. As a result, lubricity is developed on the surface of the catheter 7, and frictional resistance is reduced. After peeling (breaking) the weak seal portion 23, if necessary, the fluid substance 10 or the like is squeezed out from the second space 5 by manually pressing (pressing) the packaging material 2 from the outside. You may go.

【0086】

The first space 4 and the second space 5 have been sterilized in advance, and such an operation of developing lubricity on the surface of the catheter 7 is performed with the outside air inside the sealed packaging material 2. Since it is performed without contact, the catheter 7 can maintain sterility.

【0087】

Since the fluid substance 10 that has flowed into the first space 4 cannot permeate the container 81, the deodorant 8 in the container 81 does not get wet with the fluid substance 10, and therefore has a deodorizing function ( Deterioration of deodorant function) is prevented.

【0088】

Conventionally, in order to prevent bacterial infection, the catheter is immersed in a disinfectant solution such as 1% povidone iodine glycerin solution to disinfect the catheter before it is inserted into the living body. However, there are many cases where the adjustment of the disinfectant solution is very complicated and it is difficult to obtain the disinfectant solution itself, which puts a heavy burden on the patient himself and the safety is not sufficiently ensured. In addition, when the same catheter is repeatedly disinfected and used multiple times, it may become a hotbed for bacterial growth due to the formation of a biofilm on the surface of the catheter. On the other hand, in the present invention, as described above, the catheter 7 can be made usable (low friction state) without opening the packaging material 2, and the sterility of the catheter 7 is maintained. Since such a state can be obtained, such a conventional problem is solved.

【0089】

When the operation of developing lubricity on the surface of the catheter 7 is completed, the weak seal portion 24 is peeled (broken), the zipper 3 is opened, the catheter 7 in the first space 4 is taken out, and the catheter 7 is inserted into the target site of the living body. Or attach it. When the catheter 7 is a urethral catheter (urinary catheter), the catheter 7 is inserted into the urethra and the bladder, and urination is performed through the catheter 7. At this time, the catheter 7 can be inserted smoothly and safely because the surface of the catheter 7 has lubricity. When urination is complete, remove catheter 7 from the urethra.

【0090】

The used catheter 7 is discarded, but instead of discarding the catheter 7 alone, the catheter 7 is returned to the first space 4 of the packaging material 2, the zipper 3 is closed, and the packaging material 2 is discarded together. It is preferable to do so.

【0091】

In particular, in self-catheterization by patients, it is difficult to throw the catheter 7 into the trash can that is installed after using the catheter 7 in the private room of the toilet when going out, so it is desirable to take it home and dispose of it. .. In addition, it is not preferable that the urine odor emitted from the catheter 7 used leaks to the outside on the way home (during transportation). Further, there is a concern that bacteria, viruses, etc. in the urine may propagate due to the urine remaining in the catheter 7, which is not hygienic.

【0092】

In the present invention, when the used catheter 7 is housed in the first space 4 of the packaging material 2, the deodorant 8 eliminates or reduces odors such as urine odor emitted from the catheter 7. In addition, antibacterial agents (titanium oxide, antibacterial sheet 9, etc.) suppress the growth of bacteria, viruses, etc. As a result, the above-mentioned problems are solved, and the used catheter 7 can be hygienically transported without causing odor emission.

【0093】

FIG. 4 is a plan view (internal perspective view) showing a fifth embodiment of the package of the present invention. Hereinafter, the packaging body of the fifth embodiment will be described mainly on the differences from the first embodiment and the like, and the description of the same items will be omitted.

【0094】

As shown in FIG. 4, the packaging body 1 of the fifth embodiment has a first space 4, a second space 5, and a third space 6 partitioned by a partition portion 25 in the packaging material 2. Is.

【0095】

A band-shaped sealing portion 21 is formed on the outer peripheral portion of the packaging material 2 by fusing (or adhering) the sheet materials constituting the packaging material 2.

【0096】

The partition portion 25 is formed by fusing (or adhering) a sheet material in a strip shape like the seal portion 21, and has a T-shape. The partition portion 25 divides the inside of the packaging material 2 into an independent (isolated from each other) first space 4, a second space 5, and a third space 6, respectively.

【0097】

In this case, the first space 4, the second space 5, and the third space 6 are arranged adjacent to each other. Therefore, the movement of the liquid from the second space 5 to the first space 4, the movement from the first space 4 to the third space 6, and the like, which will be described later, can be performed quickly and reliably.

【0098】

The partition portion 22 is formed with weak seal portions 26 and 27 similar to the weak seal portion 23. By peeling (breaking) the weak seal portion 26, the first space 4 and the second space 5 communicate with each other, and by peeling (breaking) the weak seal portion 27, the first space 4 and the third space 3 It communicates with the space 6 of.

【0099】

The catheter 7 described above is housed in the first space 4, and the fluid substance 10 described above is housed in the second space 5.

【0100】

In the third space 6, the water-absorbent material 12 is stored as a substance capable of absorbing and retaining the liquid. Examples of the water-absorbent material 12 include synthetic polymers such as polyacrylate-based, polyvinyl alcohol-based, polyacrylamide-based, polyoxyethylene-based or maleic acid-based materials, and polysaccharide materials such as starch, cellulose and alginic acid. Polymer water-absorbent materials such as natural materials such as are preferred. In addition, for example, sponge, cotton, gauze, non-woven fabric, and those on which the above superabsorbent polymer material is supported (for example, those used for diapers, sanitary products, etc.) can be mentioned. These water-absorbent materials 12 can take various forms such as powder, film, sheet, and fibrous (aggregate of fibers).

【0101】

The deodorant and / or antibacterial agent described above may be stored in the first space 4 or the third space 6. In particular, when these are stored in the third space 6, the water-absorbent material 12 is supported with a deodorant (component having a deodorizing function) and / or an antibacterial agent (component having an antibacterial function) as described above. Is preferable.

【0102】

FIG. 5 is a plan view (internal perspective view) showing a sixth embodiment of the package of the present invention. Hereinafter, the packaging body of the sixth embodiment will be described mainly on the differences from the fifth embodiment and the like, and the description of the same items will be omitted.

【0103】

As shown in FIG. 5, in the packaging body 1 of the sixth embodiment, the first space 4 and the third space 6 are separated by a partition portion 25 having a weak seal portion 27, and the second space 5 is the second space. It is formed inside the space 4 of 1. That is, the catheter 7 described above and the parcel material (bag body) 11 similar to the above are housed in the first space 4 of the packaging material 2.

【0104】

The outer peripheral portion of the packaging material 11 is composed of a partition portion 22 having a weak seal portion 23, and a second space 5 is formed inside the partition portion 22. The above-mentioned fluid substance 10 is stored (filled) in the second space 5. By peeling (breaking) the weakly sealed portion 23, the first space 4 and the second space 5 communicate with each other, and the fluid substance 10 can flow into the first space 4.

【0105】

Further, in the third space 6, a water-absorbent material (substance capable of absorbing and retaining a liquid) 12 similar to the above is stored.

【0106】

The package 1 having such a configuration has the same effect (advantage) as the package 1 of the fourth embodiment.

【0107】

FIG. 6 is a plan view (internal perspective view) showing a seventh embodiment of the package of the present invention. Hereinafter, the packaging body of the 7th embodiment will be described mainly on the differences from the 5th embodiment, the 6th embodiment, and the like, and the description of the same items will be omitted.

【0108】

As shown in FIG. 6, in the package 1 of the seventh embodiment, the second space 5 and the third space 6 are formed inside the first space 4, respectively. That is, the catheter 7 and the parcel material (bag body) 14 described above are housed in the first space 4 of the packaging material 2.

【0109】

The small packaging material 14 is formed by stacking sheet materials similar to the sheet material constituting the packaging material 2 described above, and sealing the outer peripheral portion and the middle thereof by fusion (or adhesion) to form a bag shape. The second space 5 and the third space 6 are formed through the partition portion 28.

【0110】

The above-mentioned fluid substance 10 is stored (filled) in the second space 5, and the above-mentioned water-absorbent material (substance that can absorb and retain liquid) 12 is stored in the third space 6. ..

【0111】

The outer peripheral portion of the packaging material 14 and the sealing portion that crosses the middle form a partition portion 28 that isolates (partitions) the first space 4, the second space 5, and the third space 6. A weak seal portion 26 for opening the second space 5 and a weak seal portion 27 for opening the third space 6 are formed in a part of the partition portion 28. In this embodiment, the weak seal portions 27 are provided at two locations.

【0112】

The package 1 having such a configuration has the following effects (advantages). First of all, by selecting the capacity of the packaging material 14 to be put in the first space 4 (the respective capacities of the second space 5 and the third space 6), the contents (fluidity) of the packaging material 14 are selected. The amount and weight of the substance 10 and the water-absorbent material 12) can be easily set. Secondly, since the packaging material 14 can move in the first space 4, the operation of peeling (breaking) the weak seal portions 26 and 27 and the fluid substance 10 and the like are squeezed out from the second space 5. The operation and the operation of collecting the liquid into the third space 6 can be easily performed (at an appropriate position). The same applies to the third and fourth advantages of the packaging material 11 described above.

【0113】

In this embodiment, the second space 5 and the third space 6 are formed in one packaging material 14, but the present invention is not limited to this, and two separated packaging materials are formed in the first space 4. A second space 5 and a third space 6 may be formed in each of the packaging materials. Also in the case of this configuration, the same effect as described above can be obtained.

【0114】

FIG. 7 is a plan view (internal perspective view) showing an eighth embodiment of the package of the present invention. Hereinafter, the packaging body of the eighth embodiment will be described mainly on the differences from the fifth embodiment and the like, and the description of the same items will be omitted.

【0115】

As shown in FIG. 7, the package 1 of the eighth embodiment has a U-shaped second space 5 on the lower end side thereof, and the above-mentioned fluid substance is contained in the second space 5. 10 are stored (filled).

【0116】

A third space 6 is formed inside the second space 5 (on the center side of the packaging material 2) via a U-shaped partition 29, and the third space 6 is described above. Contains 12 water-absorbent materials (substances that can absorb and retain liquids).

【0117】

The partition 25 separates the first space 4 and the second space 5, and the first space 4 and the third space 6, respectively. A weak seal portion 27 for opening the third space 6 is formed in the partition portion 25.

【0118】

A sealing member 13 that can be broken and opened is installed on one side of the partition 25. The sealing member 13 is sandwiched between the partition portions 25 and fused so as to intersect the partition portion 25. Hereinafter, the configuration of the sealing member 13 will be described.

【0119】

FIG. 8 is a vertical cross-sectional view showing a configuration example of the sealing member 13. As shown in the figure, the sealing member 13 is liquid-tightly fitted into a short tube 131 made of a flexible resin such as soft polyvinyl chloride and the short tube 131, and is solid. It is composed of a tubular body 132 whose one end is closed by a columnar portion 133.

【0120】

The upper middle end of FIG. 8 of the short tube 131 communicates with the first space 4, and the lower middle end of FIG. 8 of the tubular body 132 communicates with the second space 5.

【0121】

A thin and fragile broken portion 134 is formed on the outer periphery of the cylinder 132 in the middle. The internal flow path of the sealing member 13 is opened by bending the solid columnar portion 133 together with the short tube 131 from the outside of the short tube 131 with a finger or the like to break the broken portion 134 and separating the solid columnar portion 133. .. As a result, the first space 4 and the second space 5 communicate with each other, and the fluid substance 10 in the second space 5 can flow into the first space 4.

【0122】

Examples of the constituent material of the tubular body 132 include hard materials such as hard polyvinyl chloride, polycarbonate, and polyester.

【0123】

Further, the upper end portion 135 of the solid columnar portion 133 has a wedge shape (flat shape). As a result, after the solid columnar portion 133 is fractured and separated, the solid columnar portion 133 does not block the short tube 131, and sufficient liquid flow can be ensured.

【0124】

Further, the inner diameter of the upper end portion of the short tube 131 in FIG. 8 is reduced so that the solid columnar portion 133 after fracture separation cannot pass through the reduced diameter portion 136. As a result, it is possible to prevent the fracture-separated solid columnar portion 133 from entering the first space 4 and freely moving in the first space 4.

【0125】

In the 5th, 6th, 7th, and 8th examples, the fluid substance 10 was stored in the second space 5, but in each of these examples, the fluidity Instead of the substance 10, a liquid containing a blood anticoagulant (antithrombotic agent) may be stored in the second space 5. Thereby, when the catheter 7 is used, the catheter 7 can be provided with a blood anticoagulant function. Examples of the blood anticoagulant include those shown in Table 1 below.

【0126】

[table 1]

<img file="JP2000281144A_D0001.tif" />【0127】

In each of the above examples, as the packaging material 2, a material made of a flexible sheet material is mentioned, but the present invention is not limited to this, and for example, a material partially made of a relatively hard material may be used. Good. Specific examples thereof include so-called blister containers. This blister container is made of a relatively hard material, and is composed of a main body having a recess forming a storage space (for example, a first space) and a film that airtightly seals the opening of the recess. The film is opened by peeling it off.

【0128】

Next, the usage (action) of each package 1 of the fifth to eighth examples will be described. When the weak seal portion 23 or 26 is peeled (broken) (in the case of the eighth embodiment, the solid columnar portion 133 of the sealing member 13 is broken and separated), the first space 4 and the second space 5 are separated. The fluid substance 10 stored in the second space 5 flows into the first space 4 and comes into contact with the surface of the catheter 7. As a result, lubricity is developed on the surface of the catheter 7, and frictional resistance is reduced. If necessary, the fluid substance 10 or the like may be squeezed out from the second space 5 by manually pressing (pressing) the packaging material 2 from the outside.

【0129】

The first space 4 and the second space 5 have been sterilized in advance, and such an operation of developing lubricity on the surface of the catheter 7 is performed with the outside air inside the sealed packaging material 2. Since it is performed without contact, the catheter 7 can maintain sterility. In this way, the catheter 7 can be put into a usable state (low friction state) without opening the packaging material 2, and the catheter 7 can be put into such a state while maintaining the sterility of the catheter 7. Therefore, the above-mentioned conventional problems are solved.

【0130】

When the operation of developing lubricity on the surface of the catheter 7 is completed, the weak seal portion 24 is peeled (broken), the zipper 3 is opened, the catheter 7 in the first space 4 is taken out, and the catheter 7 is inserted into the target site of the living body. Or attach it. When the catheter 7 is a urethral catheter (urinary catheter), the catheter 7 is inserted into the urethra and the bladder, and urination is performed through the catheter 7. At this time, the catheter 7 can be inserted smoothly and safely because the surface of the catheter 7 has lubricity. When urination is complete, remove catheter 7 from the urethra.

【0131】

The used catheter 7 is discarded, but instead of discarding the catheter 7 alone, the catheter 7 is returned to the first space 4 of the packaging material 2, the zipper 3 is closed, and the packaging material 2 is discarded together. It is preferable to do so.

【0132】

At this time, the weak seal portion 27 is peeled (broken) and opened by the method as described above. As a result, the first space 4 and the third space 6 communicate with each other, and body fluid such as urine that adheres to the surface of the catheter 7 or remains in the catheter 7 is stored in the third space 6. It can be absorbed and retained by the water-absorbent material 12 that has been used. As a result, the leakage of body fluid such as urine can be prevented more reliably, and the used catheter 7 can be hygienically transported together with the packaging material 2 and discarded.

【0133】

In particular, when a deodorant (component having a deodorizing function) and / or an antibacterial agent (component having an antibacterial function) is carried on the water-absorbent material 12, the emission of odor and the growth of bacteria, viruses, etc. are suppressed. However, it can be transported and disposed of more hygienically and safely.

【0134】

As described above, according to the package 1 of the present invention, it is possible to easily and aseptically contact the lubricant, blood anticoagulant, etc. with the catheter, and the transportation, opening operation, etc. by the patient, etc. are easy. Not only that, the catheter can be transported and disposed of hygienically and safely after use.

【0135】

In the present invention, examples of the appliance housed in the first space 4 include the following.

【0136】

Oral or nasal insertion of gastrointestinal catheters, feeding catheters, tube feeding tubes, oxygen catheters, oxygen canulas, endotracheal tube tubes and cuffs, tracheostomy tube tubes and cuffs, endotracheal suction catheters, etc. Catheter to be indwelled.

【0137】

-Catheters that are inserted and placed in various body cavities, organs, tissues such as suction catheters, drainage catheters, abdominal cavity catheters, rectal catheters, and trocars.

【0138】

-Catheters that are inserted and placed in blood vessels such as angiography catheters, PTCA balloon catheters, IABP balloon catheters, intravenous indwelling catheters, and intraarterial infusion catheters.

【0139】

-Various guide wires used alone or with each of the above catheters. Artificial blood vessels, stents, artificial anus, artificial bones, artificial joints, prostheses, artificial eyes. Injection needle, indwelling needle, sheath, catheter introducer.

【0140】

Endoscope, cardiac output measuring instrument, ultrasonic measuring / diagnostic instrument, ultrasonic crushing probe, pacemaker, thermometer. Thread for suturing or tying Enema · contact lens Contraceptives such as condoms [0141]

Further, in the present invention, the arrangement of the first space 4, the second space 5, and the third space 6 is not limited to that of each of the illustrated embodiments, and for example, the second space, the first space, and the like. The third space may be arranged in a row in this order. Further, the packaging material may further have a fourth space.

【0142】

Further, the first space 4, the second space 5, and the third space 6 may each contain arbitrary items other than those described above.

【0143】

[Example]

Hereinafter, the present invention will be specifically described with reference to examples.

【0144】

(Example 1A) Inflation sheet (thickness) by coextrusion molding using 60 parts by weight of polypropylene (XF1800, manufactured by Chisso Co., Ltd.) and 40 parts by weight of styrene elastomer (Hybra HVS-3, manufactured by Kuraray Co., Ltd.) 300 μm, water vapor permeability 15 g / m² 24hrs 25μm thickness 40 ° C 90% RH) was obtained. This sheet was sealed by heat fusion to form a packaging material having the configuration shown in FIG.

【0145】

In the first space of the packaging material, there are a Neraton catheter (Sufeed, 14Fr, manufactured by Terumo Corporation) as a catheter used by inserting it into the urethra, and a polyethylene non-woven fabric (trademark) which is a water-impermeable porous body. Name: Typec, deodorant / fragrance packaged by Asahi Dupont Flash Span Products Co., Ltd. (trade name: Airnip, manufactured by Tact Co., Ltd.) was added. The surface of this Neraton catheter is coated with 0.2 wt% polyvinylpyrrolidone-chloroform solution (trade name: Corridon K30, manufactured by BASF Japan Ltd.) to form a layer of hydrophilic polymer material. Was used. In addition, 10 ml of water was placed in the second space of the packaging material and sealed.

【0146】

The sealing part of the packaging material (the part other than the weakly sealed part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized by high-pressure steam at 110 ° C for 60 minutes.

【0147】

After sterilization, the package was vibrated violently, but no peeling of the weak seal was observed, and there was no contact between water and the catheter.

【0148】

Next, when the packaging material was pressed and pressed by hand to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the water in the second space flowed out into the first space. Contacted the catheter. As a result, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other.

【0149】

In addition, after the contact between water and the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. As a result, the surface showed lubricity and frictional resistance was reduced, and the insertion operation into the body cavity was performed. It was suggested that the operability of the

【0150】

Then, the catheter was immersed in artificial urine having the components shown in Table 2 below for 30 seconds, then the catheter was returned to the first space of the packaging material, the zipper was closed and sealed, and the catheter was left for a predetermined time. The face was brought close to the packaging material, but no unpleasant feeling such as urine odor was confirmed.

【0151】

Therefore, after using the catheter, the patient can easily take the catheter home without worrying about the surroundings, which not only relieves the mental burden but also prevents the urine odor from leaking to the outside air. Therefore, it was suggested that it is also preferable in terms of hygiene.

【0152】

[Table 2]

<img file="JP2000281144A_D0002.tif" />【0153】

(Examples 2A, 3A, 4A) The same inflation sheet as in Example 1A was sealed by heat fusion to form a packaging material having the structure shown in FIG.

【0154】

The same Neraton catheter (without surface coating) was placed in the first space of the packaging material, and a lubricant having the composition shown in Table 3 below was placed in the second space, and each was sealed. In addition, a deodorant, a fragrance, etc. packaged in a water-impermeable porous body shown in Table 3 below were placed in the first space.

【0155】

[Table 3]

<img file="JP2000281144A_D0003.tif" />【0156】

The sealing part of the packaging material (the part other than the weakly sealed part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized by high-pressure steam at 110 ° C for 60 minutes.

【0157】

After sterilization, the package was vibrated violently, but no peeling of the weak seal was observed, and there was no contact between the liquid in the second space and the catheter.

【0158】

Next, when the packaging material was pressed and pressed by hand to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the liquid in the second space flowed out into the first space. Contacted the catheter. As a result, it was confirmed that the liquid can be easily and aseptically contacted with the catheter.

【0159】

In addition, after the liquid in the second space came into contact with the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. The dynamic resistance value was reduced, suggesting that the operability of the insertion operation into the body cavity was improved.

【0160】

The catheter was then immersed in artificial urine of the components shown in Table 2 for 30 seconds, then the catheter was returned to the first space of the packaging material, the zipper was closed and sealed and left for a predetermined time. The face was brought close to the packaging material, but no unpleasant feeling such as urine odor was confirmed.

【0161】

Therefore, after using the catheter, the patient can easily take the catheter home without worrying about the surroundings, which not only relieves the mental burden but also prevents the urine odor from leaking to the outside air. Therefore, it was suggested that it is also preferable in terms of hygiene.

【0162】

(Examples 5A and 6A) The same inflation sheet as in Example 1A was sealed by heat fusion to form a packaging material having the structure shown in FIG.

【0163】

The same Neraton catheter (without surface coating) was placed in the first space of the packaging material, and a lubricant having the composition shown in Table 4 below was placed in the second space, and each was sealed. In addition, the antibacterial sheet shown in Table 4 below was placed in the first space.

【0164】

[Table 4]

<img file="JP2000281144A_D0004.tif" />【0165】

The sealing part of the packaging material (the part other than the weakly sealed part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized by high-pressure steam at 110 ° C for 60 minutes.

【0166】

After sterilization, the package was vibrated violently, but no peeling of the weak seal was observed, and there was no contact between the liquid in the second space and the catheter.

【0167】

Next, when the packaging material was pressed and pressed by hand to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the liquid in the second space flowed out into the first space. Contacted the catheter. As a result, it was confirmed that the liquid can be easily and aseptically contacted with the catheter.

【0168】

In addition, after the liquid in the second space came into contact with the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. The dynamic resistance value was reduced, suggesting that the operability of the insertion operation into the body cavity was improved.

【0169】

The catheter was then immersed in artificial urine of the components shown in Table 2 for 30 seconds, then the catheter was returned to the first space of the packaging material, the zipper was closed and sealed and left for a predetermined time. The face was brought close to the packaging material, but no unpleasant feeling such as urine odor was confirmed. Furthermore, the antibacterial action of the antibacterial sheet suppressed the growth of bacteria, viruses, etc. in the urine that adhered to and remained on the catheter.

【0170】

Therefore, after using the catheter, the patient can easily take the catheter home without worrying about the surroundings, which not only relieves the mental burden but also leaks the urine odor to the outside air. It was suggested that it is also preferable in terms of hygiene because there is no risk of bacterial infection.

【0171】

(Example 7A) The same inflation sheet as in Example 1A was sealed by heat fusion to form a packaging material having the structure shown in FIG.

【0172】

The same Neraton catheter (the surface was coated as in Example 1A) was placed in the first space of the packaging material, and 10 ml of water was placed in the second space, and each was sealed. .. In addition, a deodorant / antibacterial sheet containing titanium oxide (trade name: PM-IN-CD, manufactured by Mitsubishi Paper Mills Limited) was placed in the first space.

【0173】

The sealing part of the packaging material (the part other than the weakly sealed part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized by high-pressure steam at 110 ° C for 60 minutes.

【0174】

After sterilization, the package was vibrated violently, but no peeling of the weak seal was observed, and there was no contact between the liquid in the second space and the catheter.

【0175】

Next, when the packaging material was pressed and pressed by hand to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the water in the second space flowed out into the first space. Contacted the catheter. As a result, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other.

【0176】

In addition, after the water in the second space came into contact with the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. The dynamic resistance value was significantly reduced, suggesting that the operability of the insertion operation into the body cavity was improved.

【0177】

The catheter was then immersed in artificial urine of the components shown in Table 2 for 30 seconds, then the catheter was returned to the first space of the packaging material, the zipper was closed and sealed and left for a predetermined time. The face was brought close to the packaging material, but no unpleasant feeling such as urine odor was confirmed. Furthermore, the antibacterial action of the deodorizing / antibacterial sheet suppressed the growth of bacteria, viruses, etc. in the urine that adhered to and remained on the catheter.

【0178】

Therefore, after using the catheter, the patient can easily take the catheter home without worrying about the surroundings, which not only relieves the mental burden but also leaks the urine odor to the outside air. It was suggested that it is also preferable in terms of hygiene because there is no risk of bacterial infection.

【0179】

(Example 8A) The same inflation sheet as in Example 1A was sealed by heat fusion to form a packaging material containing a small packaging material having the structure shown in FIG.

【0180】

The same Neraton catheter and parcel material as in Example 1A were placed in the first space of the packaging material and sealed. The second space of the packaging material was filled with 20 ml of water and sealed. In the first space, a deodorant / fragrance (trade name) packaged with a polyethylene non-woven fabric (trade name: Typec, manufactured by Asahi DuPont Flash Span Products Co., Ltd.), which is a water-impermeable porous body, is used. : Air nip, manufactured by Tact Co., Ltd.) was added.

【0181】

The sealing part of the packaging material and the small packaging material (the part other than the weak sealing part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized by high-pressure steam at 110 ° C for 60 minutes.

【0182】

After sterilization, the package was vibrated violently, but no peeling of the weak seal was observed, and there was no contact between the liquid in the second space and the catheter.

【0183】

Then, pressing by hand the parcel material over the packaging material, compress, or the load on the weak seal part 23 where digits, only the weak seal portion 23 is peeled off, the water in the second space is the first space It spilled in and came into contact with the catheter. As a result, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other. Since the parcel material was moved to a suitable position in the packaging material and this operation was performed, the opening operation of the parcel material could be performed more easily and reliably.

【0184】

In addition, after the water in the second space came into contact with the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. The dynamic resistance value was significantly reduced, suggesting that the operability of the insertion operation into the body cavity was improved.

【0185】

The catheter was then immersed in artificial urine of the components shown in Table 2 for 30 seconds, then the catheter was returned to the first space of the packaging material, the zipper was closed and sealed and left for a predetermined time. The face was brought close to the packaging material, but no unpleasant feeling such as urine odor was confirmed. Furthermore, the antibacterial action of the deodorant / antibacterial agent suppressed the growth of bacteria, viruses, etc. in the urine that adhered to and remained on the catheter.

【0186】

Therefore, after using the catheter, the patient can easily take the catheter home without worrying about the surroundings, which not only relieves the mental burden but also leaks the urine odor to the outside air. It was suggested that it is also preferable in terms of hygiene because there is no risk of bacterial infection.

【0187】

(Example 1B) Inflation sheet (thickness) by coextrusion molding using 60 parts by weight of polypropylene (XF1800, manufactured by Chisso Co., Ltd.) and 40 parts by weight of styrene elastomer (Hybra HVS-3, manufactured by Kuraray Co., Ltd.) 300 μm, water vapor permeability 15 g / m² 24hrs 25μm thickness 40 ° C 90% RH) was obtained. This sheet was sealed by heat fusion to form a packaging material having the structure shown in FIG.

【0188】

A Neraton catheter similar to that in Example 1A was placed in the first space of the packaging material, 10 ml of water was placed in the second space, and crosslinked polyacrylic acid, which is a water-absorbing material, was placed in the third space. 1 g of sodium (trade name: Aquaric, manufactured by Nippon Shokubai Kagaku Kogyo Co., Ltd.) was added and each was sealed.

【0189】

The sealing part of the packaging material (the part other than the weakly sealed part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized with γ-rays at 2Mrad.

【0190】

After sterilization, the package was vibrated violently, but no peeling of the weak seal was observed, and there was no contact between water and the catheter or between water and the water-absorbent material.

【0191】

Next, when the packaging material was pressed and pressed by hand to apply a load to the weak seal portion 26, only the weak seal portion 26 was peeled off, and the water in the second space flowed out into the first space. Contacted the catheter. As a result, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other.

【0192】

In addition, after the contact between water and the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. As a result, the surface showed lubricity and frictional resistance was reduced, and the insertion operation into the body cavity was performed. It was suggested that the operability of the

【0193】

The catheter was then immersed in bovine blood for 30 seconds, then the catheter was returned to the first space of packaging and the zipper was closed and sealed.

【0194】

Next, when the weak seal portion 27 was opened to communicate the first space and the third space and the packaging material was vibrated, the blood adhering to and remaining on the surface and inside of the catheter became the third. It was absorbed and retained by the water-absorbent material in the space. Therefore, blood leakage did not occur even when the zipper was opened.

【0195】

Therefore, it was suggested that even if the used catheter is carried in the packaging material and discarded together with the packaging material, there is no blood leakage during that time, blood contamination and infection are prevented, and the safety is high.

【0196】

(Example 2B) An inflation sheet similar to that in Example 1B was sealed by heat fusion to form a packaging material containing a small packaging material having the structure shown in FIG.

【0197】

In the first space of the packaging material, the Neraton catheter and the guide wire (in the state of being inserted into the lumen of the catheter) similar to those in Example 1A, and the packaging material were placed and sealed. In the second space of the packaging material, 18 ml of the CPDA-1 solution shown in Table 1 was placed as a blood anticoagulant solution and sealed. In the third space of the packaging material, 2 g of crosslinked sodium polyacrylate (trade name: Aquaric, manufactured by Nippon Shokubai Kagaku Kogyo Co., Ltd.), which is a water-absorbent material, was placed and sealed.

【0198】

The sealing part of the packaging material and the small packaging material (the part other than the weak sealing part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized with γ-rays at 2Mrad.

【0199】

After sterilization, the package was violently vibrated, but no peeling of the weak seal was observed, and there was no contact between the anticoagulant solution and the catheter or contact between the anticoagulant solution and the water-absorbent material.

【0200】

Next, when the small packaging material was pressed and pressed by hand from above the packaging material and a load was applied to the weak sealing portion 23, only the weak sealing portion 23 was peeled off, and the anticoagulant liquid in the second space was released. It spilled into space 1 and came into contact with the catheter. As a result, it was confirmed that the anticoagulant solution and the catheter can be easily and aseptically contacted. Since the parcel material was moved to a suitable position in the packaging material and this operation was performed, the opening operation of the parcel material could be performed more easily and reliably.

【0201】

In addition, after the contact between the anticoagulant solution and the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. It was suggested that the operability of the insertion operation into the body cavity was improved. Further, since an anticoagulant is attached to the surface of the catheter, it is considered that the catheter exhibits an excellent anticoagulant effect when inserted into a blood vessel.

【0202】

The catheter was then immersed in bovine blood for 30 seconds, then the catheter was returned to the first space of packaging and the zipper was closed and sealed.

【0203】

Next, when the weak seal portion 27 was opened to communicate the first space and the third space and the packaging material was vibrated, the blood adhering to and remaining on the surface and inside of the catheter became the third. It was absorbed and retained by the water-absorbent material in the space. Therefore, blood leakage did not occur even when the zipper was opened.

【0204】

Therefore, it was suggested that even if the used catheter is carried in the packaging material and discarded together with the packaging material, there is no blood leakage during that time, blood contamination and infection are prevented, and the safety is high.

【0205】

(Example 3B) An inflation sheet similar to that in Example 1B was sealed by heat fusion to form a packaging material containing a small packaging material having the structure shown in FIG.

【0206】

In the first space of the packaging material, the Neraton catheter and the guide wire (in the state of being inserted into the lumen of the catheter) similar to those in Example 1A, and the packaging material were placed and sealed. 18 ml of the heparin solution shown in Table 1 above was placed in the second space of the packaging material as a blood anticoagulant solution, and in the third space, crosslinked sodium polyacrylate (trade name: Aquaric), which is a water-absorbing material, was placed. , Nippon Shokubai Kagaku Kogyo Co., Ltd.) 2 g was put in and each was sealed.

【0207】

The sealing part of the packaging material and the small packaging material (the part other than the weak sealing part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized with γ-rays at 2Mrad.

【0208】

After sterilization, the package was violently vibrated, but no peeling of the weak seal was observed, and there was no contact between the anticoagulant solution and the catheter or contact between the anticoagulant solution and the water-absorbent material.

【0209】

Next, when the upper half of the small packaging material in FIG. 6 was manually pressed and pressed from above the packaging material to apply a load to the weak seal portion 26, only the weak seal portion 26 was peeled off and the inside of the second space was filled. The anticoagulant solution spilled into the first space and came into contact with the catheter. As a result, it was confirmed that the anticoagulant solution and the catheter can be easily and aseptically contacted. Since the small packaging material was moved to a suitable position in the packaging material and this operation was performed, the opening operation of the weak seal portion 26 could be performed more easily and reliably.

【0210】

In addition, after the contact between the anticoagulant solution and the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. It was suggested that the operability of the insertion operation into the body cavity was improved. Further, since an anticoagulant is attached to the surface of the catheter, it is considered that the catheter exhibits an excellent anticoagulant effect when inserted into a blood vessel.

【0211】

The catheter was then immersed in bovine blood for 30 seconds, then the catheter and guide wire were returned to the first space of the encapsulant and the zipper was closed and sealed.

【0212】

Next, when the weakly sealed portion 27 of the parcel material was opened to communicate the first space and the third space and the packaging material was vibrated, the blood adhering to and remaining on the surface and inside of the catheter was found. It was absorbed and retained by the water-absorbent material in the third space. Therefore, blood leakage did not occur even when the zipper was opened. Since the small packaging material was moved to a suitable position in the packaging material and this operation was performed, the opening operation of the weak seal portion 27 and the absorption of residual blood could be performed more easily and reliably.

【0213】

Therefore, it was suggested that even if the used catheter is carried in the packaging material and discarded together with the packaging material, there is no blood leakage during that time, contamination and infection due to the leakage are prevented, and the safety is high.

【0214】

(Examples 4B, 5B, 6B) The same inflation sheet as in Example 1B was sealed by heat fusion to form a packaging material having the structure shown in FIG.

【0215】

A Neraton catheter (without surface coating) similar to that in Example 1B was placed in the first space of the packaging material, and a lubricant having the composition shown in Table 5 below was placed in the second space. Sealed. In addition, the water-absorbent material shown in Table 5 below was placed in the third space and sealed.

【0216】

[Table 5]

<img file="JP2000281144A_D0005.tif" />【0217】

The sealing part of the packaging material (the part other than the weakly sealed part) is 200 ° C, 4 seconds, 0.25 kgf / cm.²And the weak seal part is 105 ° C, 4 seconds, 0.25kgf / cm²Each was heat-sealed and sterilized with γ-rays at 2Mrad.

【0218】

After sterilization, the package was violently vibrated, but no peeling of the weak seal portion or breakage of the sealing member was observed, and there was no contact between the lubricant and the catheter or contact between the lubricant and the water-absorbent material.

【0219】

Next, the sealing member (structure shown in FIG. 8) was manually bent from the outside of the packaging material, the solid columnar portion was fractured and separated at the fractured portion, and the second space portion of the packaging material was pressed. The lubricant in the second space spilled into the first space and came into contact with the catheter. As a result, it was confirmed that the lubricant and the catheter can be easily and aseptically contacted with each other.

【0220】

In addition, after contact between the lubricant and the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. As a result, the surface showed lubricity, frictional resistance was reduced, and insertion into the body cavity. It was suggested that the operability of the operation was improved.

【0221】

The catheter was then immersed in artificial urine of the components shown in Table 2 for 30 seconds, then the catheter was returned to the first space of the packaging material and the zipper was closed and sealed.

【0222】

Next, when the weak seal portion 27 was opened to communicate the first space and the third space and the packaging material was vibrated, the artificial urine that had adhered to and remained on the surface and inside of the catheter was the third. Was absorbed and retained by the water-absorbent material in the space. Therefore, even if the zipper was opened, no leakage of artificial urine occurred.

【0223】

Therefore, even if the used catheter is transported in the packaging material and discarded together with the packaging material, there is no leakage of body fluid such as urine during that time, which prevents contamination and infection, suggesting that it is highly safe. Was done.

【0224】

(Example 1C) As a sheet constituting the packaging material, a polypropylene (manufactured by Mitsubishi Chemical Corporation, SPX9600) single-layer film (film thickness 300 μm, water vapor permeability 21 g / m)²A package having the configuration shown in FIG. 1 was produced in the same manner as in Example 1A except that 24 hrs, 25 μm thickness, 40 ° C, 90% RH) was used. The contents in the first space and the second space of the packaging material are the same as in Example 1A.

【0225】

(Example 2C) As a sheet constituting the packaging material, a simple polymer blend of linear low-density polyethylene (manufactured by Japan Polychem Corporation, Novatec LL UF340) and polypropylene (manufactured by Chisso Corporation, Chisso Polypro K7714) is used. Layer film (film thickness 300 μm, water vapor permeability 18 g / m²A package having the configuration shown in FIG. 1 was produced in the same manner as in Example 1A except that 24 hrs, 25 μm thickness, 40 ° C, 90% RH) was used. The contents in the first space and the second space of the packaging material are the same as in Example 1A.

【0226】

(Example 3C) As a sheet constituting the packaging material, a two-layer laminated film composed of a first layer made of a polymer blend film of linear low-density polyethylene and polypropylene and a second layer made of a silica-deposited polyethylene terephthalate film (Example 3C). Made by Dainippon Printing Co., Ltd., film thickness 300 μm, water vapor permeability 0.6 g / m²A package having the configuration shown in FIG. 1 was manufactured in the same manner as in Example 1A except that 24 hrs, 25 μm thickness, 40 ° C, 90% RH) was used so that the first layers were joined to each other. .. The contents in the first space and the second space of the packaging material are the same as in Example 1A.

【0227】

(Example 4C) The sheet constituting the packaging material is composed of a first layer made of a polymer blend film of linear low-density polyethylene and polypropylene, a second layer made of an aluminum film, and a third layer made of a polyethylene terephthalate film. 3-layer laminated film (manufactured by Toyo Aluminum Co., Ltd., film thickness 300 μm, water vapor permeability 0.3 g / m²A package having the configuration shown in FIG. 1 was manufactured in the same manner as in Example 1A except that 24 hrs, 25 μm thickness, 40 ° C, 90% RH) was used so that the first layers were joined to each other. .. The contents in the first space and the second space of the packaging material are the same as in Example 1A.

【0228】

(Example 5C) A package similar to that of Example 4C was produced except that the liquid stored in the second space was 10 ml of an aqueous glycerin solution (manufactured by Kenei Pharmaceutical Co., Ltd., glycerin concentration: 84 to 87%). ..

【0229】

&lt;Test 1&gt; Each package of Examples 1C to 5C was left in an environment of a temperature of 40 ° C. and a humidity of 75% RH for 4 weeks, and after 1 week, 2 weeks, and 4 weeks, respectively, a second space was used. The time course of the decrease rate of the liquid stored in the container was investigated. The results are shown in Table 6 below. Here, the reduction rate of the liquid was calculated by the following formula.

【0230】

Decrease rate (%) = (W₀-W) / W₀× 100 Where W₀: Total liquid weight at the start of the test (10g) W: Weight of each liquid after 1, 2 and 4 weeks [0231]

[Table 6]

<img file="JP2000281144A_D0006.tif" />【0232】

As shown in Table 6, in each of the packages of Examples 1C to 5C, the liquid reduction rate is low because the packaging material has a water vapor barrier property, and therefore the liquid in the second space is reduced and concentrated. It was confirmed that the invasion of water vapor into the first space can be prevented as well as the invasion of water vapor.

【0233】

In particular, the water vapor permeability is 1 g / m²-The packaging of Examples 3C to 5C having a thickness of 24 hrs, 25 μm, 40 ° C, and 90% RH or less has an extremely small reduction rate of liquid, and such an effect is more prominently exhibited. In Example 5C, since the liquid stored in the second space was an aqueous glycerin solution having a lower volatility than water, there was almost no decrease in the liquid.

【0234】

&lt;Test 2&gt; Each of the packages of Examples 1C to 5C was left to stand in the above environment for another 4 weeks, but the weak seal portions 23 and 24 were not peeled off, and water leaked from the second space. It did not occur.

【0235】

After that, when the portion forming the second space of the packaging material was manually pressed and pressed, the weak seal portion 23 could be easily and surely peeled off from any of the packages, and the easy peel seal property was obtained. Was confirmed to be secured.

【0236】

&lt;Examination of Effective Storage Period of Package&gt; In the package of this example, when the liquid stored in the second space is reduced by transpiration and its weight is reduced to about half or less, the weakly sealed portion due to pressurization. It becomes difficult to open (peeling). Therefore, under the conditions of this test, the time for the amount of liquid stored in the second space to decrease by half was calculated by the following formula.

【0237】

Time (year) = (5g / ΔW) × (28 days / 365 days) Here, ΔW: Amount of decrease in liquid after 4 weeks ΔW = 10g × (decrease rate of liquid after 4 weeks / 100) [0238]

As a result, Example 1C is 1.9 years, Example 2C is 2.2 years, Example 3C is 5.4 years, Example 4 is 12.7 years, and Example 5C is 38.0 years.

【0239】

From the above results, it was found that by using a packaging material having a water vapor barrier property as in Examples 1C to 5C, it is possible to suppress the decrease of the stored liquid and maintain it for a long period of time.

【0240】

[Effect of the invention]

As described above, according to the present invention, an instrument such as a catheter and a liquid can be easily and aseptically brought into contact with each other. In particular, it is possible to easily and reliably perform the communication operation between the isolated spaces in the packaging material and the opening operation of the packaging material.

【0241】

In addition, depending on the type, composition, amount, etc. of the liquid to be stored in the second space, various functions for the device, especially the surface lubricity, anticoagulant (antithrombotic), etc., can be applied to the living body. It is possible to impart an advantageous function when inserting or mounting.

【0242】

In addition, by storing the used equipment in the packaging material, it is possible to prevent the emission of odor to the outside, the growth of microorganisms, the contamination due to the leakage of the liquid adhering to or remaining on the equipment, infection, etc. It also contributes to improving safety. It is also advantageous for miniaturization of the package. Therefore, it is advantageous for disposal of used appliances, or transportation and storage until disposal.

【0243】

In particular, in self-catheterization in which the patient himself urinates using a catheter, the labor and mental burden of transporting and disposing of the used catheter when going out are reduced, so that the patient's comfortable life (quality of life). It greatly contributes to life).

[Simple explanation of drawings]

[Figure 1]

It is a top view (internal perspective view) which shows 1st Example of the package body of this invention.

[Figure 2]

It is a top view (internal perspective view) which shows 3rd Example of the package body of this invention.

[Fig. 3]

It is a top view (internal perspective view) which shows 4th Example of the package body of this invention.

[Fig. 4]

It is a top view (internal perspective view) which shows 5th Example of the package body of this invention.

[Fig. 5]

It is a top view (internal perspective view) which shows 6th Example of the package body of this invention.

[Fig. 6]

It is a top view (internal perspective view) which shows 7th Example of the package body of this invention.

[Fig. 7]

It is a top view (internal perspective view) which shows 8th Example of the package body of this invention.

[Fig. 8]

It is a vertical cross-sectional view which shows the structural example of the sealing member.

[Explanation of symbols]

1 Package 2 Packaging material 21 Seal part 22 Partition 23, 24 Weak seal part 25 dividers 26, 27 Weak seal 28, 29 dividers 3 zipper 4 First space 5 Second space 6 Third space 7 catheter 8 deodorant 81 container 9 Antibacterial sheet 10 Liquid substances 11 Defoamer 12 Water-absorbent material 13 Sealing member 131 short tube 132 Cylinder 133 Solid columnar part 134 Broken part 135 Top 136 Reduced diameter 14 Defoamer