Disinfection of substrates
30 claims: 4 independent, 26 dependent
- 1RIVENDICAZIONI 1. Un procedimento per disinfettare uri substrato, g il quale procedimento comprende il mettere a contatto detto substrato con una composizione comprendente un composto che libera biossido di cloro e una quantità ► li » sufficiente di un acido organico diverso dall'acido lat tico, per abbassare il pH dì detta composizione a meno di circa 7, detto acido organico avendo la formula ll C-OH I (I) r1_C-OH *2 j 2 in cui R e R possono essere gli stessi o differenti e possono essere scelti, dal gruppo costituito da idrogeno, metile, -CIL COOH, -CH OH, -CHOHCOOH, e -CHCH, in
- 22 2 2 b b cui il pK di detto acido organico è da circa 2,8 fino a circa 4,2. 2. Il procedimento della rivendicazione 1, in cui detto acido organico è almeno un membro scelto dal grup po costituito dagli acidi citrico, malico, tartarico, glicolico e mandelico.
- 3Il procedimento della rivendicazione 2, in cui detto acido organico è acido citrico.
- 4Il procedimento della rivendicazione 2, in cui detto acido organico è acido malico.
- 5Il procedimento della rivendicazione 2, in cui detto acido organico ò acido tartarico.
- 6Il procedimento della rivendicazione 2, in cui detto acido organico è acido gllcolico.
- 7Il procedimento della rivendicazione 2, in cui detto acido organico è acido mandelico.
- 8Il procedimento della rivendicazione 1 in cui detto pK è da circa 3 fino a circa 3,9.
- 9Il procedimento della rivendicazione 1, in cui detto composto che libera biossido di cloro è un clorito solubile in acqua.
- 10Il procedimento della rivendicazione 9, in cui detto clorito solubile in acqua è clorito di sodio e detto acido organico è almeno un membro scelto dal gru£ po costituito dagli acidi citrico, malico, tartarico, glicolico e mandelico.
- 11Il procedimento della rivendicazione 1, in cui detto composto che libera biossido di cloro e detto aei^ do organico sono entrambi forniti sotto forma di polvere.
- 12Il procedimento della rivendicazione 1, in cui detto composto che libera biossido di cloro e detto aci. do organico sono forniti in una confezione singola a due scompartimenti in cui gli scompartimenti sono separati mediante una chiusura a tenuta solubile in acqua.
- 13Un procedimento per disinfettare un substrato, il’ quale procedimento comprende ii mettere a contatto ' detto substrato con una composizione comprendente un clorito solubile in acqua e sufficiente acido organico per abbassare il pii di detta composizione a meno di cir » “ bi ca 7, detto acido organico essendo almeno uri membro scelto dal gruppo costituito dagli acidi citrico, malico, tartarico, glicolico e mandelico.
- 14Il procedimento della rivendicazione 13,in cui il clorito solubile in acqua è clorito di sodio.
- 15Una composizione sinergizzata per disinfettare un substrato, detta composizione comprendendo (a) un composto che libera biossido di cloro, (b) sufficiente acido organico diverso dall'acido lattico per abbassare il pH di detta composizione a meno di circa 7, detto acido organico avendo la formula (I) f-° H (I) r4 -C-OH I R 2 in cui e R 2 possono essere gli stessi o differenti e possono essere scelti dal gruppo costituito da idrogeno, metile, -CH^COOH, -CH^OH, -CHOHCOOH, e -CH n C^H,. , in cui il pK di detto acido organico è da circa 2,8 a circa 4,2;e - 21 (c) un composto poliidrossi vicinale.
- 16La composizione della rivendicazione 15, in cui detto acido organico è almeno un membro scelto dal gruppo costituito dagli acidi citrico, malico, tartari co, glicolico, e mandelico.
- 17La composizione della rivendicazione 16, in cui detto acido organico è acido citrico.
- 18La composizione della rivendicazione 16,in cui detto acido organico è acido malico.
- 19La composizione della rivendicazione 16, in cui detto acido organico è acido tartarico.
- 20La composizione della rivendicazione 16, in cui detto acido organico è acido glicolico.
- 21La composizione della rivendicazione 16, in cui detto acido organico è acido mandelico.
- 22La composizione della rivendicazione 15, in cui detto pK è da circa 3 fino a circa 3,9.
- 23La composizione della rivendicazione 15, in cui detto composto che libera biossido di cloro è un clorito solubile in acqua.
- 24La composizione della rivendicazione 23, in cui detto clorito solubile in acqua è clorito di sodio e det;to acido organico è almeno un membro scelto dal gruppo costituito dagli acidi citrico, malico, tartarico, glicolico e mandelico. ncc tctu i.jr A iHMMUrn
- 25La composizione della rivendicazione 15, in cui detto composto poliidrossi vicinale è un composto diidrojs si.
- 26La composizione della rivendicazione 15, in cui detto composto poliidrossi vicinale è almeno un membro scelto dal gruppo costituito da destrosio, xilosio, galattosio, mannosio, lattosio, ribosio, idrossietiic®l= luiosa, glicerina, sorbitolo, inositoli e 1,2-propilenglicol.
- 27Un procedimento per disinfettare un substrato, il quale procedimento comprende il mettere a contatto detto substrato con una composizione sinergizzata comprendente (a) un composto che libera biossido di cloro;(b) sufficiente acido organico diverso dall'acido lattico per abbassare il pH di detta composizione a meno di circa 7, detto acido organico avendo la formula (I) C-OH I f T \ R^-C-OH k I R 2 p in cui R 4 e R possono essere gli stessi o differenti e possono essere scelti dal gruppo costituito da idrogeno, metile, -CH^COOH, -C1H0H, -CHOHCOOH, e -CH,,C Η , in cui il pK di detto acido organico è da circa 2,8 fino a circa 4,2;e (c) un composto poliidrossi vicinale.
- 2811 procedimento della rivendicazione 27, in cui detto composto che libera biossido di cloro è clorito di sodio, detto acido organico è almeno un membro scelto dal gruppo costituito dagli acidi citrico, malico, tartarico, glicolico e mandelico, e detto composto pollidrossi vicinale è almeno un membro scelto dal gruppo costituito da destrosio, xilosio, galattosio, mannosio, lattosio, ribosio, idrossietilcelluiosa, glicerina, sor bitolo, inositoli e 1,2-propilen~glìcol.
- 29Il procedimento della rivendicazione 27, in cui detto composto che libera biossido di cloro e detto aci do organico sono entrambi forniti sotto forma di polvere .
- 30Il procedimento della rivendicazione 27, in cui detto composto che libera biossido di cloro e detto aci do organico sono forniti in una confezione singola solu bile in acqua a due scompartimenti^, in cui gli scompartì, menti sono separati mediante una chiusura sigìllabile col calore. FIRENZE 1 9 MAR. 1985 ICARO MAMNUCCI
Independent claims30
173 paragraphs in 28 sections, as filed
TITLE PROCEDURE FOR DISINFECTIONS IN
GENDER AND COMPOSITION 0 COMPOSITIONS WITH A COMPOUND THAT RELEASES CHLORINE DIOXIDE, FOR SUCH DISINFECTIONS
INVENTOR
DAVIDSON EUGENE A. AND KROSS ROBERT D.
ANNOT.NE THE OFFICE REFUSED THE
RECOGNITION OF THE PRIORITY ARISING FROM THE DLLA APPLICATION NO. 591787 SUBMITTED IN THE USA ON 21 3 1984 BECAUSE<sup>1</sup> THE APPLICANT HAS NOT PROVEN TO HAVE THE RIGHT
ROME, 31/05/1993
THE MANAGER (ATTILIO RONCACCI)
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PROVINCIAL OFFICE OF COMMERCE AND CRAFTS INDUSTRY
FLORENCE
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A / 86
MINUTES OF DEPOSIT FOR INDUSTRIAL INVENTION PATENT
The year 198 ..5 ... the day ......................... of the month of .......... .... mar.Z.0 .....................................
the firm
...................................................................................................................................
= Signordì nationality .Sftai.atà ... (ieX..J) .elawai ^ sÉ £ _ i „...................
(USA) = sxsidcntc ^
Street ................................................. ........................... n ................... by authorized representative £ 3Xs, IiU.Ì.S.iìi «~ Bj« ì-.GC £ lX & .. XÌ9EinU-C electively domiciled ..tt. to the effect of law to ..ElW.QSfi ........................................ .................................................. ...........
Street ................................................. ........... ..4 ..,. at .WLT.fic., ItlK..ZL.JMmUfifiÌ ...............................
has ..................... presented to me, undersigned:
1. - Application, stamp duty of L. 3,000. of PATENT FOR INDUSTRIAL INVENTION having for
TITLE
..<sup>,</sup>.<sup>,</sup>.I? Xo.Gfiiiij »ejxt.Q ... j? .Ex ... disÌai.Q2 <x, Qm .... ixi ... £ .eufìi; to ... to ... c.oap .QBàziaaa ... o .... aQw.pjQsitions for said disinfections 'ΤΓθτσ ^: ^ ιΐ) ^^ ΰ§ΘηΘΑ; ·· ^ · πίσ5'3 ·' ΤόΈέΓτ ··· ΰ ·; ..... .........
'' ♦ to * »» »****» ··
2. - Description in duplo, of w ....... 2.4, ............ pjZT.c of painting,
3. - Drawings, tables n ........................; r. mourning,
4. - Letter of appointment, (with reservation)
5. - Italian priority documents and translation, (with reservation)
6. - Authorization or Deed of Transfer, (subject to reservation)
7. - Designation of the inventor.
8. - Certificate of payment (on c / c post, n, 00668004 in the name of the Registry Office for government concessions taxes
Rome) of lire .2.7.2 .. ·. .9.9.9 ........... ... issued by the Post office. by ffflilWJ} ......... in dau13.a3. ".. 85 ...... n ..... 0.93
9. - Revenue stamp of L. 3,000 for 1<sup>1</sup> patent certification.
Priority; InUSA patent application ... d.el ... 2.1 ... March ... 1.9.84 · n?., 5.9.1 * 7.SX - a..xicma..JiAVJCI) SDK ... Eugene J and KROSS Robert D.
The application, the descriptions and the above-mentioned drawings were signed by ......... riehiedent .......... and the ladies countersigned and stamped with the official stamp.
A copy of these minutes has been signed by me and cohjej ^^ to the interested party,> · THE OFFICIAL ROGANTE <7 ^ / _ lj fc. 'i <' '·' / stXZZ-LiL IV -. ϋ £?
<sup>fl</sup> 'λ-Λ-Η
The Depositor / Vanna V
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A ........... r <sup>f</sup> : (,.......
(Case 0104-014) \;
: THE MINISTER OF INDUSTRY, COMMER C IO AND AR TI GI AN ATO
Central Patent Office - R Ο Μ A) a
ALCIDE CORPORATION
A / 85 in NORWALK, CONNECTICUT (USA)
Delaware Society, ,,. . nationality: /<sub>TTO</sub>* \ through the appointee
Ir.Ing.Gianfranco MANNUCCI and / or Dr. Luisa BACCARO MANNUCCI 2/0 Uff .Tee. Ing. A. MANNUCCI Florence, Via della Scala | where domicile is elected, a PATENT D'III ~ is requested
MENTION for:
.PROCESS FOR DISINFECTIONS IN GENERAL; 1
E COMPOSITION 0 COMPOSITION For these disinfections
INVENTORS: DAVIDSON Eugene A. and KROSS Robert D.
...............................//........../7
20η PRIORITY * (Conv.Intemaz.): US Patent Application March 21, 1964 N ° 591.787 in the name of DAVIDSON Eugene and KROSS Robert D,
TO.
in order to acquire the right by law, to adp = operate in the said industry, manufacture it and sell it exclusively. To this end, they combine:
1. Certificate of payment N ° 00¾ of Lire 272.00 = p<sub>er</sub> tax amount;
2. Description in duplo (pages, £ Z |);
4. Revenue stamp for the certificate;
1:3 «11985
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$ · Letter of assignment; (WITH RESERVE)
$. Designation of inventor.
6. Priority rights transfer document (with risi
7. Doc, priority with translation (with risejf FLORENCE 1 9 «1385
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LIST OF TAXES
Demanda ............................ Lire
1,
2.3 years ..................... Lire
Print description
Print drawings ...................... Lire
........- i i-4 ·: · .....
Total
<td>.Lire</td><td> 21.000.=</td>
<td>Lire</td><td> 56.000.=</td>
<td>Lire</td><td> 180.000.=</td>
<td>Lire</td><td> //</td>
<td>Lire</td><td> 15.000.=</td>
<td>Lire</td><td> 27 2*000,-</td>
WITH A COMPOUND THAT RELEASES CHLORINE DIOXIDE, /? A
Dr. Luisa BACCARO MANNUCCl tÌ] 1811 Order of Consultants
FLORENCE 2 5 OCT. 1383 erva) va)
ANNEX A
Corrections to the description of Patent Application No. 9366 A / 85 filed on 19.03.1985 in the name
ALCIDE CORPORATION, contained in n ° 1 note, requested with Application filed on the Provincial Office of Industry, Commerce and Crafts of Florence;
THE<sup>1</sup> adde on page 24 row 22:
31. A composition useful for the disinfection of a substrate, comprising from about 0.01 to about 0.3 per cent by weight, referred to the total weight of said composition, of a compound which releases chlorine dioxide, and a suitable quantity of an acid organic having a pK within the range of from about 2.8 to about 4.2, the pH of said composition being lower than about 7, with the proviso that said composition does not contain substantially lactic acid.
32. A composition useful for the disinfection of a substrate, comprising a compound containing at least two neighboring hydroxyl groups, from about 0.01 to about 0.3 percent by weight, based on the total weight of said composition, of a compound that releases dioxide chlorine and a suitable amount of an organic acid having a pK in the range of from about 2.8 to about
4.2, the pH of said composition being less than co about 7.
33. A process for producing a composition useful for disinfecting a substrate, said process comprising contacting from about 0.01 to about 0.3 percent by weight, based on the total weight of said composition, of a compound which liberates chlorine dioxide with a suitable quantity of an organic acid having a pK in the range from about 2.8 to about 4.2, the pH of said composition being lower than about 7, with the proviso that said composition does not contain substantially lactic acid.
34. A method for disinfecting a substrate comprising placing said substrate in contact with a composition comprising an amount of about one lo
0.01 to about 0.3 per cent by weight, based on the total weight of said composition, of a compound which releases chlorine dioxide with a suitable quantity of an organic acid having a pK in the range from about
2.8 to about 4.2, the pH of said composition being less than about 7, with the condition that said component 7; sition does not contain substantially lactic acid.
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FLORENCE - 5 FED. 15
?. TO.
> L. Eli, · BACCARO MANNUCCI
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- X
2 £ ® ££ i £ Ì £££ _É £ ìlii £££££££££ _iH ^ ££ Ì £ Ì £ Ì £ _
PROCEDURE FOR GENERAL DISINFECTIONS AND COMPOSITION-
<td>NEITHER</td><td>0 COMPOSITIONS WITH A</td><td>COMPOSED</td><td>THAT</td><td>FREE DIOXIDE</td>
<td>OF</td><td colspan="2">CHLORINE, FOR SUCH DISINFECTIONS</td><td>of</td><td>ALCIDE CORPORATION</td>
<td>a</td><td>Delaware company</td><td>(USA),</td><td>to</td><td>NORWALK, Oonnecticut</td>
(USA); filed on 9 MAR- 198θ__N ^^ Pro ΐ ^ _9 3 6 6 _A / 8 5
SUMMARY
From a first point of view, a procedure is described
UFF. IKK. ING. k MÀNUCC1
Description modified (ert. 49 DPR n. 338 / 197S) instances dep. 6. action to disinfect a substrate. This process comprises contacting the substrate with a composition comprising a compound which liberates chlorine dioxide, such as sodium chlorite, with a sufficient amount of an organic acid other than lactic acid to lower the pH of the composition to less than about 7 Organic acid has the formula
II
C-OH "
R -C-OH I ρ R ^ (I) where R<sup>1</sup> and R<sup>2</sup> they can be the same or different and they can be chosen from the group consisting of hydrogen, methyl, -CH ^ COOH,
-CH OH, -CHOHCOOH, and -CH CH. The pK of organic acid 2 2 6 5 ranges from about 2.8 to about 4.2. In another aspect, the present invention provides a synergized composition for disinfecting a substrate. This composition you understood! compound that releases chlorine dioxide and the organic acid mentioned above as well as a neighboring polyhydroxy compound such as glycerin. In a further aspect, a method is disclosed for disinfecting a substrate using this synergized composition.
DESCRIPTION
This invention refers generally to compositions for disinfecting substrates as well as procedures for preparing and using such compositions.
The term disinfectant is used in this description to generally understand any substance or composition that disinfects, determines hygienic situations, deodorises, sterilizes, or kills germs.
The use of chlorine compounds in various types of compositions, disinfectants is well known. The chlorine compounds suggested for use for this purpose include, for example, sodium hypochlorite, used in the first world war for washing wounds, and chlorinated phenols such as 1-m-chlorophenol. These compounds exhibit increased bactericidal activity and reduced toxicity, in some cases, when compared to non-chlorinated phenols. Therefore, 1'm-chlorophenol has a phenol coefficient of 5.8 (S. aureus) up to 7.4 (B. of typhus). Other chlorine compounds having some form of disinfectant effect include, for example, the same chlorine gas, chlorine bios, chloramine-T, mercuric chloride,
Calcium hypochlorite (a normal swimming pool disinfectant), chloropìcrine (a larvicide), chloroform (a fumigant), chlordane (an insecticide), zinc chloride (a preservative) and eloromycetin (an antibiotic) .
Chlorine dioxide in particular has been found to be a remarkably effective disinfectant. This compound is somewhat versatile and has long been used as a bleaching agent for example in the oxidation of the natural color present in cotton, wood pulp and other cellulose fibrous materials. Therefore, chlorine dioxide, while exhibiting an oxidizing function, is not however harmful with respect to the fibrous material.
Furthermore, chloride dioxide has been used for a long time in the treatment of water reserves and a precursor (i.e. a base product from which said dioxide can be released) is currently commercially available in the form of a powder for use in swimming pools and in the form of liquid for domestic and industrial cleaning and disinfection. In general, chlorine dioxide is superior to gaseous chlorine in the removal of odors, flavors, and in the destruction and removal of algae or other organic material. Furthermore, chlorine dioxide is considered at least equally effective if not £ * higher than chlorine gas as bactericidal, sporicidal and
YES to kill viruses. Chlorine dioxide is further advantageous in that its antiseptic properties are not as sensitive to pH as in the case of chlorine, i.e. chlorine dioxide maintains its disinfectant capacity to a considerably higher degree and over a wider pH range than I know chlorine gas.
Despite the multiple advantages obtainable through the use of chlorine dioxide for the purposes described and indicated above, however, in practice there are difficulties. Therefore chlorine dioxide as a concentrated gas is explosive and poisonous and consequently is not usually shipped in the gaseous state to an average or small user. It has therefore become common practice to employ a compound that releases chlorine dioxide as sodium chlorite powder which is much safer from the point of view of storage, shipping and handling. The formation of chlorine dioxide from sodium chlorite or other compounds that release chlorine dioxide is usually carried out by the addition of either an acid, or a bleaching product (hypochlorite), or chlorine to the compound that liberates dioxide chlorine.
Formation by means of a dioxide acid of this is generally carried out with the use of a relatively convenient inorganic acid: for example hydrochloric acid, sulfuric acid and the like. The acid fo1 acid sfico ο<sup>Λ</sup>βοοΐίοο (vinegar) soctoa sometimes recommended for home use since they are relatively safe to handle and generally available with ease.
Canadian patent 959.238 registered to Calerame describes a conventional method for producing chlorine dioxide by reacting a chlorite of an alkali metal or an alkaline earth metal, such as sodium chlorite, with an acid. In general, any acid can be used comprising strong acids such as sulfuric acid and hydrochloric acid and relatively dole acids such as citric and tartaric.
The acidic formation of chlorine dioxide from sodium chlorite as recommended and practiced so far has proven ineffective in most cases. The composition resulting from the acidification of the sodium chlorite does not usually explain the desired disinfectant efficacy, especially from the point of view of the germ destruction rate. To compensate for this deficiency, it becomes necessary to use a higher concentration of sodium chlorite and acid, which can lead to problems of
UlUUt '/ Y toxicity, especially when the composition is used in an air space i.e. in a closed environment.
ck
Another problem stems from the fact that the composition <sub>t</sub> tion obtained from the interaction between sodium chlorite and the acidic material does not provide a truly effective solvent environment for the active chlorine containing products such as chlorine dioxide, chlorine acid and the like.
Inhalation of these components in any significant measure can be harmful to health. Significantly, the problem of toxicity imposes severe limitations on the general usefulness of the disinfectant composition, particularly with regard to the treatment of human beings.
These previous methods result in the almost complete and rapid conversion of the precursor (or base product), that is, chlorite into chlorine dioxide, which is then used in the form of gas or, less frequently, in solution.
The problems in the use of chlorine dioxide as a disinfectant indicated above have been solved to some extent by the use of a composition comprising a water soluble chlorite such as sodium chlorite and lactic acid. As described in the U.S. patent 4.084.747 registered to Alliger, this particular composition has improved disinfectant properties, i.e. properties that cannot be obtained using the same composition but by completely replacing lactic acid with other acids such as phosphoric acid, acetic acid, acid sorbic, fumaric acid, sdlfamic acid, succinic acid, boric acid, tannic acid and citric acid. It would be preferable, from the point of view of the cheapness and availability of the acid, to be able to use acids other than lactic acid, still obtaining the disinfectant effect, and to keep control over the speed of formation of the chlorine acid and therefore of the dioxide of chlorine.
The search for improved compositions for disinfecting substances carrying various germs and for improved disinfection methods has therefore continued. This invention was made as a result of that research.
Consequently, it is a general object of the present invention to avoid or substantially decrease the problems mentioned above.
A more specific object of the present invention is to provide improved compositions for cleaning, sterilization and disinfection.
A further purpose of the<sup>1</sup> The invention is to provide such disinfectant compositions which have negligible toxicity under conditions normally prescribed for use and are therefore very useful in the germicidal treatment of substrates such as containers and utensils for food, medical equipment, human or animal skin diseases, and the like.
Another object of the present invention is to provide such compositions so that they have controlled stability over a relatively wide pH range.
A further object of the present invention is to provide a method for disinfecting various substrates.
Another object of the present invention is to provide a method for disinfecting substrates using compositions having negligible toxicity and controlled stability over a relatively wide pH range.
Other objects and advantages of the present invention will become apparent from the following summary of the invention and from the description of the preferred embodiments.
The present invention provides, in a first aspect, a method for disinfecting a substrate.
This process comprises contacting the substrate with a composition comprising a compound which liberates chlorine dioxide with a sufficient amount of an organic acid other than lactic acid, to lower the pH of the composition to less than about 7.
UFF. TUR. WS. A. MAIS
Organic acid has the formula
II
C-OH
R ^ -C-OH <sub>R</sub>2 where R ^ and R ^ can be the same or different and can be selected from the group consisting of hydrogen, methyl, -C1LCOOH, -CH OH, -CHOHCOOH, and "CH C H. The pK 2 2 2 b ό of the acid organic is from about 2.8 up to about 4.2.
In another aspect, the present invention provides a synergized composition for disinfecting a substrate. This composition comprises (a) a compound which releases chlorine dioxide;
(b) a sufficient amount of the organic acid described above to lower the pH of the composition to less than about 7; and (c) a neighboring polyhydroxy compound.
In a further aspect, the present invention provides a method for disinfecting a substrate using the synergized composition described above.
The present composition employs a compound which releases chlorine dioxide as one of the components of the disinfectant composition. By compound that releases chlorine dioxide is meant any compound that, if treated properly, releases chlorine dioxide.
While any compound which liberates chlorine dioxide can be used, water soluble chlorites are preferred since they are readily available and inexpensive.
Typical water soluble chlorites include alkali metal chlorites and alkaline earth metal chlorites.
Sodium chlorite and potassium chlorite are preferred.
Sodium chlorite is particularly preferred.
The disinfectant composition can be used uni.
only to an application medium. The application medium can be any compatible medium comprising a gel or a liquid such as water. An aqueous application medium is preferred. The application medium may contain other additives such as chelating agents (for example Na EDTA), surfactants (for example PluronicFee or Nacconal alkylaryl sulfonate), or preservatives (for example sodium benzoate).
The amount of the chlorine dioxide releasing compound, which is used in this composition, can generally be from about 0.01 to about 1, typically from about 0.02 to about 0.5, and preferably from about 0.03 to about 0.3% by weight of the total composition (including the application medium).
The organic acid used in the present invention can be citric, malic, tartaric, glycolic, mandelic or other structurally similar acids as described in Formula I above. They can also perform IECN A MAMMHfTì “jii<sup>: ι</sup> mixtures of two or more of these organic acids are used. Ht
The pK of these organic acids can be generated- - '<sup>:</sup>From about 2.0 to about 4.2 and preferably from about 3.0 to about 4.0.
I Γ · Ι'Λ
F
The amount of organic acid used should be sufficient to lower the content of the composition to less than about 7, typically from about 2 to about 5, and preferably from about 2.2 to about 2.7. Furthermore, this amount can generally be from about 0.01 to about 6, typically from about 0.05 to about 3, and preferably from about 0.1 to about 2% by weight of the total composition (comprising the application medium) .
The chlorine dioxide releasing compound is generally kept separate from the organic acid prior to use in order to avoid a premature reaction of the ingredients.
In a preferred embodiment, the disinfectant composition contains a vinylic polyhydroxy compound, preferably a neighborhood hydroxy compound, and more preferably a dihydroxy compound with cis hydroxyl groups. The neighboring polyhydroxy compounds are well known to those skilled in the art and include dextrose and other sugars, such as xylose, galactose, mannose, lactose and ribose, hydroxyethylcellulose, glin cerin, sorbitol, inositols, and 1,2-propylene glycol.
The use of such neighboring polyhydroxy compounds together with the compound which releases chlorine dioxide and organic acid gives rise to a synergized composition.
For example, the rate of formation of the entity of
active medium using a composition comprising sodium chlorite and mandelic acid is substantially increased by the addition of a relatively inconsistent amount of a neighboring polyhydroxy compound. Therefore, the use in the composition of little dextrose, such as the
2%, substantially increases the rate of formation of the entity or active medium in comparison with a composition containing only sodium chlorite and one of the organic acids indicated above. In other words, a composition comprising the neighborhood polyhydroxy compound can be prepared, which substantially, over a specified period of time, has the same germ-destroying efficacy as a composition that does not contain the polyhydroxy compound even if the composition containing the compound polyhydroxy contains substantially much smaller amounts of organic acid and sodium chlorite.
The amount of polyhydroxy compound can vary widely, but in the present invention less than about 50 is typically employed typically from about to about 20 and preferably from about 2 to about: 10 weight percent of the total composition.
The compositions described above can be used to disinfect various substrates. The term abstract used in the present description is intended to indicate any type of surface or support which could provide a locus for the accumulation of germs, viruses, spores, bacteria, fungi, i.e. all types of parasitic microorganisms. Clear examples include surgical and dental instruments, containers for food, human and animal skin, tissue and mucous membranes (mouth tissue), swimming pools, domestic water tanks, waste containers, bathroom appliances etc. The cleaning action can be improved with the addition of a wetting agent, the latter being compatible with or devoid of any tendency to react with chlorine dioxide. Particularly effective wetting agents for such use are anionic surfactants which are commercially available. The present compositions in the form of aerosols can be used effectively to destroy airborne or atmospheric germs such as those present in an air space or closed environment.
When these compositions are used on human or animal hair, they can also be applied in a typical way together with an application medium consisting of a gel given the ability of the gel to adhere to the skin. Any salifying or thickening agent can be used, which is non-toxic and does not tend to react.
turn with the compound that releases chlorine dioxide and with <sup>£</sup> is
organic acid. Cellulose gels, particularly methyl cellulose gels and polyamide and silica based gels are preferred. Preservatives can also be used when the gel form is used. For example, sodium benzoate can be used as stored in the gel of an organic acid.
The amount of thickener in the gel varies according to the type of acid and chlorine dioxide liberating compound used. However, the amount can generally be from about 0.5 to about 8, typically from about to about 3, and preferably from about 2.5 to about 2.7 weight percent of the gel. The amount of preservative in the gel can generally be from about 0.01 to about 0.05, typically from about 0.01 to about 0.04, and preferably from about 0.02 to about 0.03 weight percent of the total composition.
When the compound which releases chlorine dioxide and organic acid are present in separate gels, the quantities of each present in the respective gel are regulated so that, when the gels are mixed, the specified percentages are present in the resulting composition. For example, when the gels are intended to be mixed in equal parts, which is preferred, the amount of the compound which releases chlorine dioxide «
present in the first gel can generally be from approx
0.02 to about 2, typically from about 0.01 to about 1, and preferably from about 0.1 to about 0.6 percent by weight of the first gel. The amount of organic acid in the second gel can be from about 0.1 to about 12, typically from about 0.5 to about 10, and preferably from about 1 to about 6 weight percent of the second gel.
In addition, when the compound that releases chlorine dioxide and organic acid are present in separate gels, the preservative is present only in that gel that contains organic acid and the thickener is present in both gels.
Therefore, when the gels are expected to be chosen in equal parts, the amount of preservative present in the second gel, the organic acid gel, is generally from about 0.02 to about 0.1, typically from about 0 , 02 to about 0.08, and preferably from about 0.04 to about 0.06 weight percent of the second gel, and the amount of thickener present in both the first and second gels is generally from about 0.5 to about 4, typically from about 2 to about 3, and preferably from about
2.5 to about 2.7 weight percent of each gel.
These gels can be mixed immediately before application or can be simultaneously mixed and applied on site.
A small but effective amount of the composition can be applied to the infected area of the skin using any means known to those skilled in the art, including, for example, an applicator such as a cotton swab. The composition is left to remain on the infected area for a sufficient period of treatment. The composition can be applied again to maintain an effective level of the composition throughout the period of the treatment.
For most skin irritations, a repeat of one or two applications provides relief. In most cases the composition can be applied freely on the affected spot, preferably as soon as possible after inflammation appears. If applied in the form of a liquid, a suitable applicator is a cotton gauze moistened with a liquid formulation. The lesion or infected area must be kept in contact with the wet gauze for a few minutes.
When a gel is used, it must be applied freely. If the gel is accidentally absorbed or removed, it can be applied again as needed.
These compositions can also be used in flFF TFCN. In B. A. MAHHtìCCI soap products, toothpaste pastes, mouthwashes and the like.
In addition to the gel and the solution form, the organic acid and the compound that releases chlorine dioxide can also be supplied in the form of a powder in two packages or in a single two-compartment package in which the compartments are separated by a suitable sealing. One embodiment of such a package uses as a material for the packaging a material based on polyvinyl alcohol and water-soluble cellulose, heat-sealable. Other materials suitable for packaging, compatible with the ingredients of the composition, are well known to those skilled in the art.
packaging material may contain neighboring hydroxy groups and therefore also serve as a synergist.
This Invention is illustrated by the Example below. All parts and percentages in the Example, as well as in the description and claims, are by weight, unless otherwise specified.
EXAMPLE
This Example illustrates the use of this composition as a mouthwash.
A first solution is prepared by dissolving
0.4 grams of technical grade sodium chlorite, 0.17 grams of Na ^ EDTA4H<sub>?</sub>0 in powder form, 0.5 grams of 1-carvone (mint flavor) and the appropriate quantity of a compatible yellow food coloring in 500 mil_liter of aqueous solution. A second solution is prepared by dissolving 1,375 grams of anhydrous citric acid and the appropriate amount of FD&C bleu in a dozen 500 milliliters of a 10 percent aqueous solution by weight of glycerin.
The two solutions are mixed, preferably immediately before use, in substantially equal quantities and the mixture is used as a mouthwash in the usual way. This results in improved bactericidal, fungicidal and taste properties compared to the currently available commercial antiseptic mouthwashes.
The principles, the preferred embodiments and the operating modes of the invention have been illustrated in the above description. The invention which is intended to be protected here must not however be conceived as limited to the particular forms described below.
for these are to be regarded as illustrative rather than restrictive. Variations and modifications can be made by those skilled in the art without departing from the spirit of the invention.
Sri
SS1
Contents28
9 sheets
Sheet 1 Sheet 2 Sheet 3 Sheet 4 Sheet 5 Sheet 6 Sheet 7 Sheet 8 Sheet 9
46 members in 27 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 59178784 | United States of America | A | |
| 59178784 | United States of America | A | |
| 8509366 | – | – | – |
| US19840591787 | – | – | – |
Members46
| Document | Office | Kind | |
|---|---|---|---|
| IT8509366A0 | Italy | A0 | |
| IT8509366D0 | Italy | D0 | |
| GR850689B | Greece | B | |
| WO8504107A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU4151785A | Australia | A | |
| FI854497A | Finland | A | |
| FI854497A0 | Finland | A0 | |
| FI854497L | Finland | L | |
| DK531885A | Denmark | A | |
| DK531885D0 | Denmark | D0 | |
| NO854623L | Norway | L | |
| ZA852033B | South Africa | B | |
| BR8506045A | Brazil | A | |
| EP0176558A1 | European Patent Office (EPO) | A1 | |
| JPS61501495A | Japan | A | |
| EP0176558A4 | European Patent Office (EPO) | A4 | |
| MC1721A1 | Monaco | A1 | |
| HUT40335A | Hungary | A | |
| ES541411A0 | Spain | A0 | |
| ES8702793A1 | Spain | A1 | |
| OA08138A | African Intellectual Property Organization (OAPI) | A | |
| IN160430B | India | B | |
| MW3785A1 | Malawi | A1 | |
| RO95098A | Romania | A | |
| RO95098B | Romania | B | |
| NZ211434A | New Zealand | A | |
| AU584080B2 | Australia | B2 | |
| IL74684A | Israel | A | |
| MX161768A | Mexico | A | |
| US4986990A | United States of America | A | |
| EG17596A | Egypt | A | |
| US5100652A | United States of America | A | |
| EP0176558B1 | European Patent Office (EPO) | B1 | |
| AT84224T | Austria | T | |
| ATE84224T1 | Austria | T1 | |
| NO171881B | Norway | B | |
| US5185161A | United States of America | A | |
| DE3586959D1 | Germany | D1 | |
| CA1314477C | Canada | C | |
| DE3586959T2 | Germany | T2 | |
| NO171881C | Norway | C | |
| IT1237359BThis record | Italy | B | |
| DK168362B1 | Denmark | B1 | |
| AR246433A1 | Argentina | A1 | |
| JPH0745368B2 | Japan | B2 | |
| USRE36064E | United States of America | E |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Fee payment date (situation as of event date), data collected since 19931001TA | TA |
Numbers
- Publication, DOCDB
- 1237359
- Publication, EPODOC
- IT1237359
- Application
- 8509366
- Application, DOCDB
- 936685
- Application, EPODOC
- IT19850009366
Titles2
- English
- Disinfection of substrates
- Italian
- PROCEDIMENTO PER DISINFEZIONI IN GENERE E COMPOSIZIONE O COMPOSIZIONI CON UN COMPOSTO CHE LIBERA BIOSSIDO DI CLORO, PER DETTE DISINFEZIONI
Classification
- CPC, 2
- C01B11/024
- A01N59/00
- IPC, 11
- A61L2 20
- A01N
- A01N37 02
- A01N59 00
- A01N59 08
- A61L
- A61L2 00
- A61L2 18
- C01B
- C01B11 00
- C01B11 02
