Nova Patents
IS7069A

Process for the production of n- 3-(3-cyanopyrazolo 1,5-a pyrimidin-7-yl)phenyl -n-ethylacetamide (zaleplon)

Abstract

The present invention provides a process for the production of N-[3(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.

Term

Term ended

Projected expiry passed 10 December 2023, 2.8 years ago.

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309 members in 21 offices

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Priority claims
DocumentOfficeKindDate
29763501United States of AmericaP
29763501United States of AmericaP
0218567United States of AmericaW
0218567United States of AmericaW
PCTUS0218567–––
US20010297635P–––
WO2002US18567–––

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CA2450384A1CanadaA1
WO02100828A2World Intellectual Property Organization (WIPO)A2
CA2453751A1CanadaA1
WO03011228A2World Intellectual Property Organization (WIPO)A2
US2003040522A1United States of AmericaA1
WO02100828A3World Intellectual Property Organization (WIPO)A3
US2003130291A1United States of AmericaA1
WO03011228A3World Intellectual Property Organization (WIPO)A3
IS7069AThis recordIcelandA
NO20035538D0NorwayD0
KR20040007683ARepublic of KoreaA
IS7128AIcelandA
NO20040887LNorwayL
KR20040019085ARepublic of KoreaA
EP1406871A2European Patent Office (EPO)A2
IL159281D0IsraelD0
MXPA03011485AMexicoA
IL160076D0IsraelD0
MXPA04001035AMexicoA
EP1430054A2European Patent Office (EPO)A2
CN1537113AChinaA
HRP20040016A2CroatiaA2
CZ20033544A3CzechiaA3
CZ200471A3CzechiaA3
TR200402588T3TürkiyeT3
SK16232003A3SlovakiaA3
SK472004A3SlovakiaA3
ZA200309677BSouth AfricaB
HRP20040180A2CroatiaA2
EP1406871A4European Patent Office (EPO)A4
US6852858B2United States of AmericaB2
DE02778962T1GermanyT1
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HU0402253A2HungaryA2
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HUP0402253A2HungaryA2
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JP2005507858AJapanA
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ZA200400378BSouth AfricaB
US6884888B2United States of AmericaB2
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PL372942A1PolandA1
JP2005523874AJapanA
US2005187225A1United States of AmericaA1
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