Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Abstract
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
Term
Term ended
Projected expiry passed 19 December 2021, 4.8 years ago.
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106 members in 54 offices
Priority claims6
| Document | Office | Kind | Date |
|---|---|---|---|
| 14213099 | United States of America | P | |
| 0018263 | United States of America | W | |
| 60142130 | – | – | – |
| PCTUS0018263 | – | – | – |
| US19990142130P | – | – | – |
| WO2000US18263 | – | – | – |
Members106
| Document | Office | Kind | |
|---|---|---|---|
| CA2383630A1 | Canada | A1 | |
| DZ3191A1 | Algeria | A1 | |
| WO0102369A2 | World Intellectual Property Organization (WIPO) | A2 | |
| AU5785200A | Australia | A | |
| UY26231A1 | Uruguay | A1 | |
| PE20010306A1 | Peru | A1 | |
| NO20015797D0 | Norway | D0 | |
| IS6207AThis record | Iceland | A | |
| GT200000107A | Guatemala | A | |
| NO20015797L | Norway | L | |
| NO20060596L | Norway | L | |
| KR20020027379A | Republic of Korea | A | |
| WO0102369A3 | World Intellectual Property Organization (WIPO) | A3 | |
| BR0012352A | Brazil | A | |
| EP1218348A2 | European Patent Office (EPO) | A2 | |
| IL146710D0 | Israel | D0 | |
| PA8498001A1 | Panama | A1 | |
| CO5190686A1 | Colombia | A1 | |
| EA200200120A1 | Eurasian Patent Organization (EAPO) | A1 | |
| MXPA01012795A | Mexico | A | |
| CZ20014634A3 | Czechia | A3 | |
| BG106380A | Bulgaria | A | |
| CN1374950A | China | A | |
| SK19252001A3 | Slovakia | A3 | |
| HU0202490A2 | Hungary | A2 | |
| SV2002000121A | El Salvador | A | |
| HU0202490A3 | Hungary | A3 | |
| JP2003503481A | Japan | A | |
| ZA200110061B | South Africa | B | |
| EE200100717A | Estonia | A | |
| US6531491B1 | United States of America | B1 | |
| US6534524B1 | United States of America | B1 | |
| HK1048813A1 | Hong Kong, China | A1 | |
| NZ516676A | New Zealand | A | |
| HRP20020109A2 | Croatia | A2 | |
| CN1137884C | China | C | |
| EA004460B1 | Eurasian Patent Organization (EAPO) | B1 | |
| CN1495171A | China | A | |
| PL355757A1 | Poland | A1 | |
| UA66933C2 | Ukraine | C2 | |
| AR035554A1 | Argentina | A1 | |
| US2004171634A1 | United States of America | A1 | |
| YU92901A | Yugoslavia, later Serbia and Montenegro (until 2006) | A | |
| AU777701B2 | Australia | B2 | |
| US2004220248A1 | United States of America | A1 | |
| MA26803A1 | Morocco | A1 | |
| HK1065037A1 | Hong Kong, China | A1 | |
| US2005038097A1 | United States of America | A1 | |
| US6884890B2 | United States of America | B2 | |
| US6891044B2 | United States of America | B2 | |
| US2005124662A1 | United States of America | A1 | |
| JO2319B1 | Jordan | B1 | |
| AP1486A | African Regional Intellectual Property Organization (ARIPO) | A | |
| TNSN00146A1 | Tunisia | A1 | |
| CN1234693C | China | C | |
| EP1614683A1 | European Patent Office (EPO) | A1 | |
| KR100529639B1 | Republic of Korea | B1 | |
| OA11980A | African Intellectual Property Organization (OAPI) | A | |
| GEP20063885B | Georgia | B | |
| HK1085470A1 | Hong Kong, China | A1 | |
| CR6517A | Costa Rica | A | |
| TWI262914B | Taiwan Province of China | B | |
| NO322507B1 | Norway | B1 | |
| US7141581B2 | United States of America | B2 | |
| US7141587B2 | United States of America | B2 | |
| JP2006348043A | Japan | A | |
| JP3878849B2 | Japan | B2 | |
| JP3969669B2 | Japan | B2 | |
| EP1218348B1 | European Patent Office (EPO) | B1 | |
| AT376543T | Austria | T | |
| EP1614683B1 | European Patent Office (EPO) | B1 | |
| DE60036879D1 | Germany | D1 | |
| PT1218348E | Portugal | E | |
| DE60037211D1 | Germany | D1 | |
| PT1614683E | Portugal | E | |
| DE60036879T2 | Germany | T2 | |
| DK1218348T3 | Denmark | T3 | |
| SI1218348T1 | Slovenia | T1 | |
| SI1614683T1 | Slovenia | T1 | |
| DK1614683T3 | Denmark | T3 | |
| ES2293906T3 | Spain | T3 | |
| ES2296014T3 | Spain | T3 | |
| HRP20020109B1 | Croatia | B1 | |
| CR10194A | Costa Rica | A | |
| CA2383630C | Canada | C | |
| DE60037211T2 | Germany | T2 | |
| MY137622A | Malaysia | A | |
| SK286936B6 | Slovakia | B6 | |
| AR065937A2 | Argentina | A2 | |
| RS50339B | Serbia | B | |
| MY139999A | Malaysia | A | |
| CZ301667B6 | Czechia | B6 | |
| BG66070B1 | Bulgaria | B1 | |
| ME00385B | Montenegro | B | |
| MEP45108A | Montenegro | A | |
| IS2791B | Iceland | B | |
| PL212108B1 | Poland | B1 | |
| EE05585B1 | Estonia | B1 | |
| CY1107147T1 | Cyprus | T1 | |
| NO2013004I1 | Norway | I1 |
Numbers
- Publication
- 6207
- Publication, DOCDB
- 6207
- Publication, EPODOC
- IS6207
- Application
- 6207
- Application, DOCDB
- 6207
- Application, EPODOC
- IS20010006207
Titles
- Icelandic
- Indazol efnasambönd og lyfjafræðilegar blöndur til að hindra prótín kínasa og aðferð til að nota þau
Classification
- CPC, 33
- C07D403/12
- A61P3/00
- A61P3/10
- C07D209/18
- A61P9/00
- C07D231/56
- C07D401/04
- A61P9/10
- C07D401/06
- A61P17/00
- A61P17/06
- C07D401/12
- A61P19/00
- C07D401/14
- A61P19/02
- C07D403/04
- C07D405/04
- A61P27/00
- C07D405/06
- A61P27/02
- A61P27/06
- C07D405/14
- C07D409/06
- A61P29/00
- A61P35/00
- C07D409/14
- C07D413/12
- A61P43/00
- C07D417/06
- C07D417/12
- C07D417/14
- C07D471/04
- C07D491/04
- IPC, 47
- C07D231 00
- A61K31 416
- A61K31 4178
- A61K31 4184
- A61K31 4188
- A61K31 4196
- A61K31 4245
- A61K31 427
- A61K31 437
- A61K31 4439
- A61K31 444
- A61K31 454
- A61K31 4709
- A61K31 496
- A61K31 5377
- A61P3 10
- A61P9 10
- A61P17 06
- A61P19 02
- A61P27 02
- A61P27 06
- A61P29 00
- A61P35 00
- A61P43 00
- C07D209 18
- C07D231 56
- C07D401 04
- C07D401 06
- C07D401 12
- C07D401 14
- C07D403 04
- C07D403 12
- C07D403 14
- C07D405 04
- C07D405 06
- C07D405 14
- C07D409 06
- C07D409 12
- C07D409 14
- C07D413 12
- C07D413 14
- C07D417 06
- C07D417 12
- C07D417 14
- C07D471 04
- C07D491 04
- C07D491 056