Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases

1 207609/2

PYRIMIDINE-2-AMINE COMPOUNDS AND USE THEREOF IN THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING JAK KINASES

FIELD OF THE INVENTION

The present invention relates to compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the compounds or salts, and to use thereof in the manufacture of a medicament for inhibiting JAK kinases, particularly JAK2, and for treating diseases and conditions associated with JAK activity.

BACKGROUND OF THE INVENTION

Protein kinases constitute a large family of structurally related enzymes that are responsible for the control of a variety of signal transduction processes within cells (see, e.g., Hardie and Hanks, The Protein Kinase Facts Book, I and II, Academic Press, San Diego, CA, 1995). Protein kinases are thought to have evolved from a common ancestral gene due to the conservation of their structure and catalytic function. Almost all kinases contain a similar 250-300 amino acid catalytic domain. The kinases can be categorized into families by the substrates they phosphorylate (e.g., protein-tyrosine, protein-serine/threonine, lipids, etc.). Sequence motifs have been identified that generally correspond to each of these families (see, e.g., Hanks & Hunter, (1995), FASEB J. 9:576-596; Knighton et al., (1991), Science 253:407-414; Hiles et al., (1992), Cell 70:419-429; Kunz et al., (1993), Cell 73:585-596; Garcia-Bustos et al., (1994), EMBO J. 13:2352-2361). JAK kinases (JAnus Kinases) are a family of cytoplasmic protein tyrosine kinases including JAK1, JAK2, JAK3 and TYK2. Each of the JAK kinases is selective for the receptors of certain cytokines, though multiple JAK kinases can be affected by particular cytokine or signaling pathways. Studies suggest that JAK3 associates with the common gamma (γο) chain of the various cytokine receptors. JAK3, in particular, selectively binds to receptors and is part of the cytokine signaling pathway for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. JAK1 interacts with, among others, the receptors for cytokines IL-2, IL-4, IL-7, IL-9 and IL-21, while JAK2 interacts with, among others, the receptors for IL-9 and TNF-a. Upon the binding of certain cytokines to their receptors (e.g., IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21), receptor oligomerization occurs, resulting in the cytoplasmic tails of associated JAK kinases being brought into proximity and facilitating the transphosphorylation of tyrosine residues on the JAK kinase. This trans-phosphorylation results in the activation of the JAK kinase.

Phosphorylated JAK kinases bind various STAT (Signal Transducer and Activator of Transcription) proteins. STAT proteins, which are DNA binding proteins activated by 2 207609/2 phosphorylation of tyrosine residues, function both as signaling molecules and transcription factors and ultimately bind to specific DNA sequences present in the promoters of cytokine-responsive genes (Leonard et al., (2000), J. Allergy Clin.

Immunol.105:877-888). JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses such as allergies, asthma, autoimmune diseases such as transplant (allograft) rejection, rheumatoid arthritis, amyotrophic lateral sclerosis and multiple sclerosis, as well as in solid and hematologic malignancies such as leukemia and lymphomas. For a review of the pharmaceutical intervention of the JAK/STAT pathway see Frank, (1999), Mol. Med. 5:432:456 and Seidel et al., (2000), Oncogene 19:2645-2656.

As described above, JAK's are crucial components of diverse signal transduction pathways that govern important cellular functions, including cell survival, proliferation, differentiation and apoptosis. Interfering with JAK activity may lead to the loss of a vital signal transduction pathway, thereby disrupting normal cellular processes needed for cell survival. Therefore, it is important to selectively inhibit particular JAK's that are involved in various disease states. JAK2 associates with cytokine receptors and is essential for signal transduction by mediating tyrosine phosphorylation. JAK2 activity is regulated by a series of interactions, beginning with binding to specific domains in receptors, suppression of activation by the pseudokinase domain, and the requirement for phosphorylation within the activation loop. Recent studies have implicated deregulation of JAK2 kinase activity by chromosomal translocations in hematopoietic tumors and mutations within the pseudokinase domain in a spectrum of myeloproliferative diseases (Ihle, J N et al., Current Opinion in Genetics and Development (2007) 17:1, 8-14.

In addition, JAK2 has been suggested to be involved in the upregulation of angiotensinogen promoter activity in hypertrophy and ischemia (Mascareno E, et al. (2000) Mol. Cell. Biochem., 212:171-175; and Mascareno E, et al. (2001) Circulation, 104:1). One particular tyrphostin, AG490, selectively inhibits JAK2 and has been proposed for treating cancer (Meydan N, et al. (1996) Nature, 379:645). Administration of tyrphostin AG490 has been suggested to afford cardioprotection to hearts subjected to ischemia/reperfusion (Mascareno E, et al. (2000) Mol. Cell. Biochem., 212:171 and Mascareno E, et al. (2001) Circulation, 104:1). TG101209, a JAK2-selective compound, has been recently shown to be effective in inhibiting mutations in myeloproliferative disorders (Pardanani A, et al. (2007) Leukemia, 1-11). JAK3, in particular, has been implicated in a variety of biological processes. For example, the proliferation and survival of murine mast cells induced by IL-4 and IL-9 have been shown to be dependent on JAK3- and gamma chain- signaling (Suzuki et al., 3 207609/2 (2000), Blood 96:2172-2180). JAK3 also plays a crucial role in IgE receptor- mediated mast cell degranulation responses (Malaviya et al., (1999), Biochem. Biophys. Res. Commun. 257:807-813), and inhibition of JAK3 kinase has been shown to prevent type I hypersensitivity reactions, including anaphylaxis (Malaviya et al., (1999), J. Biol. Chem. 274:27028-27038). JAK3 inhibition has also been shown to result in immune suppression for allograft rejection (Kirken, (2001), Transpl. Proc. 33:3268-3270). JAK3 kinases have also been implicated in the mechanism involved in early and late stages of rheumatoid arthritis (Muller-Ladner et al., (2000), J. Immunol. 164:3894-3901); familial amyotrophic lateral sclerosis (Trieu et al., (2000), Biochem Biophys. Res. Commun. 267:22-25); leukemia (Sudbeck et al., (1999), Clin. Cancer Res. 5:1569-1582); mycosis fungoides, a form of T-cell lymphoma (Nielsen et al., (1997), Prac. Natl. Acad. Sci. USA 94:6764-6769); and abnormal cell growth (Yu et al., (1997), J. Immunol. 159:5206-5210; Catlett-Falcone et al., (1999), Immunity 10:105-115).

The JAK kinases, including JAK3, are abundantly expressed in primary leukemic cells from children with acute lymphoblastic leukemia, the most common form of childhood cancer, and studies have correlated STAT activation in certain cells with signals regulating apoptosis (Demoulin et al., (1996), Mol. Cell. Biol. 16:4710-6;

Jurlander et al., (1997), Blood. 89:4146-52; Kaneko et al., (1997), Clin. Exp. Immun. 109:185-193; and Nakamura et al.,(1996), J. Biol. Chem. 271:19483-8). They are also known to be important to lymphocyte differentiation, function and survival. JAK-3, in particular, plays an essential role in the function of lymphocytes, macrophages, and mast cells. Given the importance of this JAK kinase, compounds which modulate the JAK pathway, including those selective for JAK3, can be useful for treating diseases or conditions where the function of lymphocytes, macrophages, or mast cells is involved (Kudlacz et al., (2004) Am. J. Transplant 4:51-57; Changelian (2003) Science 302:875878). Conditions in which targeting of the JAK pathway or modulation of the JAK kinases, particularly JAK3, are contemplated to be therapeutically useful include leukemia, lymphoma, transplant rejection (e.g., pancreas islet transplant rejection), bone marrow transplant applications (e.g., graft-versus-host disease), autoimmune diseases (e.g., RA, type I diabetes), and inflammation (e.g., asthma, allergic reactions).

Conditions which can benefit for inhibition of JAK2 are discussed in greater detail below.

In view of the numerous conditions that are contemplated to benefit by treatment involving modulation of the JAK pathway, it is immediately apparent that new compounds that modulate JAK pathways and methods of using these compounds should provide substantial therapeutic benefits to a wide variety of patients.

Related Disclosures 4 207609/2

Patents and patent applications related to modulation of the JAK pathway include: U.S. Pat. Nos. 5728536; 6080747; 6080748; 6133305; 6177433; 6210654; 6313130; 6316635; 6433018; 6486185; 6506763; 6528509; 6593357; 6608048; 6610688; 6635651; 6677368; 6683082; 6696448; 6699865; 6777417; 6784195; 6825190; 6506763; 6784195; 6528509; 6608048; 7105529; 6699865; 6825190; 6815439; 6949580; 7056944; 6998391; 7074793; 6969760; U.S. Pat. App. Pub. Nos. 2001/0007033 A1; 2002/0115173 A1; 2002/0137141 A1; 2003/0236244 A1; 2004/0102455 A1; 2004/0142404 A1; 2004/0147507 A1; and 2004/0214817 A1; and

International Published Patent Application Nos. WO 95/03701A1; WO 99/15500A1; WO 00/00202A1; WO 00/10981A1; WO 00/47583A1; WO 00/51587A2; WO 00/55159A2; WO 01/42246A2; WO 01/45641A2; WO 01/52892A2; WO 01/56993A2; WO 01/57022A2; WO 01/72758A1; WO 02/00661A1; WO 02/43735A1; WO 02/48336A2;

WO 02/060492A1; WO 02/060927A1; WO 02/096909A1; WO 02/102800A1; WO

03/020698A2; WO 03/048162A1; WO 03/101989A1; WO 2004/016597A2; WO 2004/041789A1 2004/046120A2 2004/085388A2 2005/028475A2 WO 2004/041810A1; WO 2004/041814A1; WO 2004/046112A2; WO WO 2004/047843A1; WO 2004/058749A1; WO 2004/058753A1; WO WO 2004/092154A1; WO 2005/009957A1; WO 2005/016344A1; WO and WO 2005/033107A1.

All of the above publications are herein incorporated by reference in their entireties to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference in its entirety.

SUMMARY OF THE INVENTION

This invention is directed to 2-pyrimidineamine compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts thereof, and to use thereof in the manufactuer of a medicament for the treatment of conditions in which inhibition of JAK kinases, particularly JAK2, can be therapeutically useful.

Accordingly, in one aspect, this invention is directed to compounds of formula (Ia):

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(la) or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1 or 2; 5 207609/2 m is 0, 1 or 2; Y is selected from the group consisting of =C(R6)- and =N-; R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, -R8-C(O)OR6, -R9-N(R6)R7 and -R9-OR6; 10 15 20 each R2, when present is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; each R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of aryl and heteroaryl, where the aryl and the heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, N-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted aralkyl, and where the N-heterocyclyl, the N-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5 is an N-heterocyclyl selected from: 25 6 207609/2 10

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each R5a is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)tR6 15 20 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally 25 7 207609/2 substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; and each R9 is independently selected from the group consisting of an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; as an isolated stereoisomer or a mixture thereof.

Other featutres described in the instant application are directed to compounds of formula (I):

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I R1 (I) and pharmaceutically acceptable salts thereof, wherein: Θ is selected from the group consisting of a six-membered aryl and a sixmembered heteroaryl; n is 0, 1 or 2; m is 0, 1, 2, 3 or 4; R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, -R8-C(O)OR6, -R9-N(R6)R7 and -R9-OR6; each R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, haloalkyl, cyano, nitro, -OR6, -N(R6)2, -C(O)OR6 and -C(O)N(R6)2; each R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of aryl and heteroaryl, where the aryl and the heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of oxo, alkyl, halo, haloalkyl, 8 207609/2 cyano, N-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted aralkyl, and where the N-heterocyclyl, the N-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5 is an N-heterocyclyl, wherein a nitrogen atom in the N-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)tR6 (where t is 1 or 2); and a carbon atom in the N-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, haloalkynyl, oxo, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)pR6 (where p is 0, 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, 9 207609/2 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; and each R9 is independently selected from the group consisting of an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; provided at least one of R5 and a substituent on R4 is a bridged N-heterocyclyl; as an isolated stereoisomer or a mixture thereof and when comprising one or more stereoisomeric substituents.

In another aspect, this invention is directed to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a compound of the invention, as described herein, as an isolated stereoisomer or mixture thereof, or a pharmaceutically acceptable salt thereof.

In another aspect, this invention is directed to uses of a compound of the invention for manufacturing a medicament for inhibiting JAK2 activity in a mammal, as described and claimed herein.

Other features described in the instant application are directed to methods of treating a disease or condition associated with JAK activity in a mammal, particularly JAK2, wherein the methods comprise administering to the mammal a therapeutically effective amount of a compound of the invention, as described above, as an isolated stereoisomer or mixture thereof, or a pharmaceutically acceptable salt thereof, or a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the invention, as described herein, as an isolated stereoisomer or mixture thereof, or a pharmaceutically acceptable 9a 207609/2 salt thereof.

Other features described in the instant application are directed to assays to determine the effectiveness of a compound of the invention in inhibiting JAK activity, particularly JAK2 activity, in a cell-based assay.

Other features described in the instant application are directed to a method of inhibiting an activity of a JAK kinase comprising contacting the JAK kinase with an amount of a compound effective to inhibit an activity of the JAK kinase, wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein.

Other features described in the instant application are directed to a method of inhibiting an activity of a JAK kinase comprising contacting in vitro a JAK2 kinase with an amount of a compound effective to inhibit an activity of the JAK kinase, wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein

Other features described in the instant application are directed to a method of inhibiting an activity of a JAK kinase comprising contacting in a cell a JAK2 kinase with an amount of a compound effective to inhibit an activity of the JAK2 kinase, wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein.

Other features described in the instant application are directed to a method of treating a T-cell mediated autoimmune disease comprising administering to a patient suffering from such an autoimmune disease an amount of a compound effective to treat the autoimmune disease, wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein.

Other features described in the instant application are directed to a method of treating allograft transplant rejection in a mammal, preferably a transplant recipient, comprising administering to the mammal a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, as described herein.

Other features described in the instant application are directed to a method of treating a Type IV hypersensitivity reaction in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, as described herein.

Other features described in the instant application are directed to a method of inhibiting a signal transduction cascade in which JAK2 kinase plays a role comprising contacting a cell expressing a receptor involved in such a signaling cascade with an inhibitory amount of a compound of the invention, or a pharmaceutically acceptable salt 9b 207609/2 thereof, as described herein.

Other features described in the instant application are directed to a method of treating a JAK kinase-mediated disease or condition in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, as described herein.

Other features described in the instant application are directed to a method of treating a JAK2 kinase-mediated myeloproli tive disorder (MPD), such as polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) or JAK-dependent malignancies in a mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, as described herein.

Other features described in the instant application are directed to a kit comprising a compound selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, packaging, and instructions for use.

DETAILED DESCRIPTION OF THE INVENTION

DEFINITIONS

As used in the specification and appended claims, unless specified to the contrary, the following terms have the meaning indicated:

Ring A" refers to in compounds of formula (I), as described above in the

Summary of the Invention. "Amino" refers to the -NH2 radical. "Carboxy" refers to the -C(O)OH radical. "Cyano" refers to the -CN radical. "Nitro" refers to the -NO2 radical. "Oxa" refers to the -O- radical. "Oxo" refers to the =O radical. "Thioxo" refers to the =S radical. "Alkyl" refers to a fully saturated, straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, having from one to twelve carbon atoms, one to eight carbon atoms or one to six carbon atoms and which is attached to the rest of a molecule by a single bond, for example, methyl, ethyl, n-propyl, 1-methylethyl (iso-propyl), n-butyl, n-pentyl, 1,1-dimethylethyl (t-butyl), 3-methylhexyl, 10 2-methylhexyl, and the like. For purposes of this invention, the term "lower alkyl" refers to an alkyl radical having one to six carbon atoms. "Optionally substituted alkyl" refers to an alkyl radical, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of halo, cyano, nitro, oxo, thioxo, trimethylsilanyl, -OR20, -OC(O)-R20, -N(R20)2, -C(O)R20, -C(O)OR20, -C(O)N(R20)2, -N(R20)C(O)OR20, -N(R20)C(O)R20, -N(R20)S(O)2R20, -S(O)tOR20 (where t is 1 or 2), -S(O)PR20 (where p is 0, 1 or 2), and -S(O)2N(R20)2 where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20’s, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heterocyclyl or an optionally substituted N-heteroaryl. "Alkenyl" refers to a straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, containing at least one double bond, having from one to twelve carbon atoms, or one to eight carbon atoms, and which is attached to the rest of a molecule by a single bond or a double bond, for example, ethenyl, prop-1-enyl, but-1-enyl, pent-1-enyl, penta-1,4-dienyl, and the like. "Optionally substituted alkenyl" refers to an alkenyl radical, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of halo, cyano, nitro, oxo, thioxo, trimethylsilanyl, -OR20, -OC(O)-R20, -N(R20)2, -C(O)R20, -C(O)OR20, -C(O)N(R20)2, -N(R20)C(0)OR20, -N(R20)C(O)R20, -N(R20)S(O)2R20, -S(O),OR20 (where t is 1 or 2), -$(O)PR20 (where p is 0,1 or 2), and -S(O)2N(R20)2 where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryi, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryi and optionally substituted heteroarylalkyl, or two R20,s, together with the common nitrogen to which they are both attached, form an optionally substituted N-heterocyclyl or an optionally substituted /V-heteroaryl. "Alkynyl" refers to a straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, containing at least one triple bond, optionally containing at least one double bond, having from two to twelve carbon atoms, or two to 10 11 eight carbon atoms, and which is attached to the rest of a molecule by a single bond or a double bond, for example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like. "Optionally substituted alkynyl" refers to an alkynyl radical, as defined above, which is optionally substituted by one or more substituents selected from the group 5 consisting of halo, cyano, nitro, oxo, thioxo, trimethylsilanyl, -OR20, -OC(O)-R20, -N(R20)2, -C(O)R20, -C(O)OR20, -C(O)N(R20)2, -N(R20)C(O)OR20, -N(R20)C(O)R20, -N(R20)S(O)2R20, -S(O)tOR20 (where t is 1 or 2), -S(O)PR20 (where p is 0, 1 or 2), and -S(O)2N(R20)2 where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, 10 optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyciylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20's, together with the common nitrogen to which they are both attached, form an optionally substituted W-heterocyclyl or an optionally substituted N-heteroaryl. 15 "Straight or branched alkylene chain" refers to a straight or branched divalent hydrocarbon chain linking the rest of a molecule to a radical group, consisting solely of carbon and hydrogen, containing no unsaturation and having from one to twelve carbon atoms, for example, methylene, ethylene, propylene, n-butylene, and the like. The alkylene chain is attached to the rest of a molecule through a single bond and to the 20 radical group through a single bond. The points of attachment of the alkylene chain to the rest of a molecule and to the radical group can be through one carbon in the alkylene chain or through any two carbons within the chain. "Optionally substituted straight or branched alkylene chain" refers to an alkylene chain, as defined above, which is optionally substituted by one or more substituents 25 selected from the group consisting of halo, cyano, nitro, aryl, cycloalkyl, heterocyclyl, heteroaryl, oxo, thioxo, trimethylsilanyl, -OR20, -OC(O)-R20, -N(R20)2, -C(O)R20, -C(O)OR20, -C(O)N(R20)2, -N(R20)C(O)OR20, -N(R20)C(O)R20, -N(R20)S(O)2R20, -S(O)tOR20 (where t is 1 or 2), -S(O)PR20 (where p is 0, 1 or 2), and ~S(O)2N(R20)2 where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally 30 substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyciylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20,s, together with the common nitrogen to which they are both attached, form an optionally substituted N-heterocyclyl or an optionally substituted N- 35 heteroaryi. 11 12 "Straight or branched aikenylene chain" refers to a straight or branched divalent hydrocarbon chain linking the rest of a molecule to a radical group, consisting solely of carbon and hydrogen, containing at least one double bond and having from one to twelve carbon atoms, for example, ethenylene, propenylene, n-butenylene, and the like. 5 The aikenylene chain is attached to the rest of a molecule through a double bond or a single bond and to the radical group through a double bond or a single bond. The points of attachment of the aikenylene chain to the rest of the molecule and to the radical group can be through one carbon or any two carbons within the chain. "Optionally substituted straight or branched aikenylene chain" refers to an 10 aikenylene chain, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of halo, cyano, nitro, aryl, cycloalkyl, heterocyclyl, heteroaryl, oxo, thioxo, trimethylsilanyl, -OR20, -OC(O)-R20, -N(R20)2l -C(O)R20, -C(O)OR20, -C(O)N(R20)2i -N(R20)C(O)OR20, -N(R20)C(O)R20, -N(R20)S(O)2R20, -S(O),OR20 (where t is 1 or 2). -S(O)PR20 (where p is 0, 1 or 2), and -S(O)2N(R20)2 where 15 each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycioalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20's, together with the common nitrogen to 20 which they are both attached, form an optionally substituted W-heterocyclyl or an optionally substituted A/-heteroaryl. "Straight or branched alkynylene chain" refers to a straight or branched divalent hydrocarbon chain linking the rest of a molecule to a radical group, consisting solely of carbon and hydrogen, containing at least one triple bond and having from two to twelve 25 carbon atoms, for example, propynylene, n-butynylene, and the like. The alkynylene chain is attached to the rest of a molecule through a single bond and to the radical group through a double bond or a single bond. The points of attachment of the alkynylene chain to the rest of a molecule and to the radical group can be through one carbon or any two carbons within the chain. 30 "Optionally substituted straight or branched alkynylene chain" refers to an alkynylene chain, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkenyl, halo, haloalkenyl, cyano, nitro, aryl, cycloalkyl, heterocyclyl, heteroaryl, oxo, thioxo, trimethylsilanyl, -OR20, -OC(O)-R20, -N(R20)2, -C(O)R20, -C(O)OR20, -C(O)N(R20)2, -N(R20)C(O)OR20, 35 -N(R20)C(O)R20, -N(R20)S(O)2R20, -S(O)|OR20 (where t is 1 or 2), -S(O)PR20 (where p is 0, 12 13 1 or 2), and -S(O)2N(R20)2 where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20's, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heterocyclyl or an optionally substituted N-heteroaryl. "Aryl" refers to a hydrocarbon ring system radical comprising hydrogen, 6 to 14 carbon atoms and at least one aromatic ring. For purposes of this invention, the aryl radical may be a monocyclic, bicyclic, or tricyclic system and which may include spiro ring systems. An aryl radical is commonly, but not necessarily, attached to a parent molecule via an aromatic ring of the aryl radical. Aryl radicals include, but are not limited to, aryl radicals derived from acenaphthylene, anthracene, azulene, benzene, 6,7,8,9-tetrahydro-5H-benzo[7]annulene, fluorene, as-indacene, s-indacene, indane, indene, naphthalene, phenalene, and phenanthrene. "Optionally substituted aryl" refers to an aryl radical, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, haloalkynyl, cyano, nitro, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl. -R2’-OR20, -R21-OC(O)-R20, -R2’-N(R20)2, -R21-C(O)R20, -R2’-C(O)OR20, -R2’-C(O)N(R20)2, -R2,-O-R22-C(O)N(R20)2, -R2,-N(R20)C(0)OR20, -R2’-N(R2°)C(O)R20, -R2’-N(R20)S(O)2R2,), -R21-C(=NR20)N(R20)2, -R2,-S(O),OR20 (where t is 1 or 2), -R2’-S(O)pR2° (where p is 0, 1 or 2), and -R2,-S(O)2N(R20)2, where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20’s, together with the common nitrogen to which they are both attached, form an optionally substituted N-heterocyclyl or an optionally substituted N- 13 14 heteroaryl, each R21 is independently a direct bond or a straight or branched alkylene or alkenyiene chain, and R22 is a straight or branched alkylene or alkenylene chain. "Aralkyl" refers to a radical of the formula -Rb-Rc where Rb is an alkylene chain as defined above and Rc is one or more aryl radicals as defined above, for example, benzyl, 5 diphenylmethyl and the like. "Optionally substituted aralkyl" refers to an aralkyl radical, as defined above, wherein the alkylene chain of the aralkyl radical is an optionally substituted alkylene chain, as defined above, and each aryl radical of the aralkyl radical is an optionally substituted aryl radical, as defined above. 10 "Aralkenyi" refers to a radical of the formula -Rd-Rc where Rd is an alkenylene chain as defined above and Rc is one or more aryl radicals as defined above. "Optionally substituted aralkenyi" refers to an aralkenyi radical, as defined above, wherein the alkenylene chain of the aralkenyi radical is an optionally substituted alkenylene chain, as defined above, and each aryl radical of the aralkenyi radical is an &gt; 15 optionally substituted aryl radical, as defined above. "Aralkynyl" refers to a radical of the formula -ReRc where Re is an alkynylene chain as defined above and Rc is one or more aryl radicals as defined above. "Optionally substituted aralkynyl" refers to an aralkynyl radical, as defined above, wherein the alkynylene chain of the aralkynyl radical is an optionally substituted 20 alkynylene chain, as defined above, and each aryl radical of the aralkynyl radical is an optionally substituted aryl radical, as defined above. "Cycloalkyl" refers to a stable non-aromatic monocyclic or polycyclic hydrocarbon radical consisting solely of carbon and hydrogen atoms, which includes fused, spiro or bridged ring systems, having from three to fifteen carbon atoms, or having from three to 25 ten carbon atoms, or from five to seven carbons and which is saturated or unsaturated and attached to the rest of a molecule by a single bond. For purposes of this invention, a bridged ring system is a system wherein two non-adjacent ring atoms thereof are connected through an atom or a group of atoms, wherein the atom or the group of atoms are the bridging element. An example of a bridged cycloalkyl (monovalent) radical is 30 norbornanyl (also called bicyclo[2.2.1 jheptanyl). For purposes of this invention, a non-bridged ring system is a system which does not contain a bridging element, as described above. For purposes of this invention, a fused ring system is a system wherein two adjacent ring atoms thereof are connected through an atom or a group of atoms. An example of a fused cycloalkyl (monovalent) radical is decahydronaphthalenyl (also called 35 decalinyl). For purposes of this invention, a spiro ring system is a system wherein two 14 15 rings are joined via a single carbon (quaternary) atom. An example of a spiro cycloalkyl (monovalent) radical is spiro[5.5]undecanyl. Monocyclic cycloalkyl radicals do not include spiro, fused or bridged cycloalkyl radicals, but do include for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Polycyclic 5 radicals include fused, spiro or bridged cycloalkyl radicals, for example, Ci0 radicals such as adamantanyl (bridged) and decalinyl (fused), and C7 radicals such as bicyclo[3.2.0]heptanyl (fused), norbornanyl and norbornenyl (bridged), as well as substituted polycyclic radicals, for example, substituted C7 radicals such as 7,7-dimethylbicyclo[2.2.1]heptanyl (bridged), and the like. 10 "Optionally substituted cycloaikyl" refers to a cycloalkyl radical, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, haloalkynyl, oxo, thioxo, cyano, nitro, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloaikyl, 15 cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted 20 heteroarylalkynyl, -R21-OR20, -R21-OC(O)-R20, -R21-N(R20)2, -R21-C(O)R20, -R21-C(O)OR20, -R21-C(O)N(R20)2, -R21-N(R20)C(O)OR2d, -R21-N(R20)C(O)R20, -R21-N(R20)$(O)2R20, -R21-C(=NR20)N(R20)2, -R21-S(O)tOR20 (where t is 1 or 2), -R2t-S(O)PR20 (where p is 0, 1 or 2), and -R21-S(O)2N(R20)2, where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloaikyl, optionally 25 substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20ls, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heterocyclyl or an optionally substituted /V-heteroaryl, and each R21 is independently a 30 direct bond or a straight or branched alkylene or alkenylene chain. "Cycloalkylalkyl" refers to a radical of the formula -RbRg where Rb is an alkylene chain as defined above and Rg is a cycloaikyl radical as defined above. "Optionally substituted cycloalkylalkyl" refers to a cycloalkylalkyl radical, as defined above, wherein the alkylene chain of the cycloalkylalkyl radical is an optionally 35 substituted alkylene chain, as defined above, and the cycloaikyl radical of the 15 16 cycloalkylalkyl radical is an optionally substituted cycloalkyl radical, as defined above. "Cycloalkylalkenyl" refers to a radical of the formula -RdRg where Rd is an alkenylene chain as defined above and Rg is a cycloalkyl radical as defined above. "Optionally substituted cycloalkylalkenyl" refers to a cycloaikylalkenyl radical, as 5 defined above, wherein the alkenylene chain of the cycloalkylalkenyl radical is an optionally substituted alkenylene chain, as defined above, and the cycloalkyl radical of the cycloalkylalkenyl radical is an optionally substituted cycloalkyl radical as defined above. "Cycloalkylalkynyl" refers to a radical ofthe formula -ReRg where Re is an 10 alkynylene radical as defined above and Rg is a cycloalkyl radical as defined above. "Optionally substituted cycloalkylalkynyl" refers to a cycloalkylalkynyl radical, as defined above, wherein the alkynylene chain of the cycloalkylalkynyl radical is an optionally substituted alkynylene chain, as defined above, and the cycloalkyl radical of the cycloalkylalkynyl radical is an optionally substituted cycloalkyl radical as defined 15 above. "Halo" refers to bromo, chloro, fluoro or iodo. "Haloalkyl" refers to an alkyl radical, as defined above, that is substituted by one or more halo radicals, as defined above, for example, trifluoromethyl, difluoromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 1-fluoromethyl-2-fluoroethyl, 3-bromo-2-f!uoropropyl, 20 1-bromomethyl-2-bromoethyl, and the like. "Haloalkenyl" refers to an alkenyl radical, as defined above, that is substituted by one or more halo radicals, as defined above. "Hafoalkynyl" refers to an alkynyl radical, as defined above, that is substituted by one or more halo radicals, as defined above. 25 "Heterocyclyl" refers to a stable 3- to 18-membered non-aromatic ring system radical which comprises one to twelve carbon atoms and from one to six heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur. Unless stated otherwise specifically in the specification, the heterocyclyl radical may be a monocyclic, bicyclic, tricyclic or tetracyclic ring system, which may include spiro or bridged ring 30 systems; and the nitrogen, carbon or sulfur atoms in the heterocyclyl radical may be optionally oxidized; the nitrogen atom may be optionally quaternized; and the heterocyclyl radical may be partially or fully saturated. Examples of a bridged heterocyclyl include, but are not limited to, azabicyclo[2.2.1]heptanyl, diazabicyclo[2.2.1jheptanyl, oxazabicyclo[2.2.1jheptanyl, diazabicyclo[2.2.2]octanyl, 35 azabicyclo[3.2.1]octanyl, diazabicyclo[3.2.1]octanyl, azabicyclo[3.3.1]nonanyl, , 16 17 diazabicyclo[3.3.1]nonanyl, azabicyclo[3.2.2.]nonanyl, diazabicyclo(3.2.2]nonanyl, 6,9-methanooctahydropyrido[1,2-ajpyrazinyl, azabicyclo[3.3.2]decanyl and diazabicyclo[3.3.2]decanyl. A "bridged /V-heterocyclyl" is a bridged heterocyclyl containing at least one nitrogen, but which optionally contains up to four additional heteroatoms selected from Ο, N and S. For purposes of this invention, a non-bridged ring system is a system wherein no two non-adjacent ring atoms thereof are connected through an atom or a group of atoms. Examples of heterocyclyl radicals include, but are not limited to, dioxolanyl, 1,4-diazepanyl, decahydroisoquinolyl, imidazolinyi, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, octahydro-1 H-pyrrolo[3,2-c]pyridinyl, octahydro-1 H-pyrroIo[2,3-cjpyridinyl, octahydro-1H-pyrrolo[2,3-b]pyridinyl, octahydro-1 H-pyrrolo[3,4-b]pyridinyl, octahydropyrrolo[3,4-c]pyrrolyl, octahydro-1 H-pyrido[1,2-ajpyrazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, 3,7-diazabicyclo[3.3.1]nonan-3-yi, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinucltdinyl, thiazolidinyl, tetrahydrofuranyl, thienyl[1,3Jdithianyl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxo-thiomorpholinyl, azetidinyl, octahydropyrrolo[3,4-c]pyrrolyl, octahydropyrrolo[3,4-b]pyrrolyl, decahydroprazino[1,2-a]azepinyl, azepanyl, azabicyclo[3.2.1]octyl, and 2,7-diazaspiro[4.4]nonany!. "Optionally substituted heterocyclyl" refers to a heterocyclyl radical, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, haloalkynyl, oxo, thioxo, cyano, nitro, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R21-OR20, -R21-OC(O)-R20, -R21-N(R20)2, -R21-C(O)R20, -R21-C(O)OR20 -R21-C(O)N(R20)2, -R21-N(R20)C(O)OR2d, -R21-N(R2d)C(O)R20, -R21-N(R20)S(O)2R20, -R^-C(=NR20)N(R20)2, -R21-S(O),OR20 (where t is 1 or 2), -R21-S(O)PR20 (where p is 0, 1 or 2), and -R21-S(O)2N(R20)2, where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, 17 18 optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20,s( together with the common nitrogen to which they are both attached, form an optionally substituted /V-heterocyclyl or an optionally substituted N-heteroaryl, and each R21 is independently a direct bond or a straight or branched alkylene or alkenylene chain. "/V-heterocyclyl’1 refers to a heterocyclyl radical as defined above containing at least one nitrogen and where the point of attachment of the /V-heterocyclyl radical to the rest of a molecule may be through a nitrogen atom in the /V-heterocyclyl radical or through a carbon in the /V-heterocyclyl radical. "Optionally substituted /V-heterocyclyl" refers to an /V-heterocyclyl, as defined above, which is optionally substituted by one or more substituents as defined above for optionally substituted heterocyclyl. "Heterocyclylalkyl" refers to a radical of the formula -RbRh where Rb is an alkylene chain as defined above and Rh is a heterocyclyl radical as defined above, and when the heterocyclyl is a nitrogen-containing heterocyclyl, the heterocyclyl may be attached to the alkylene chain at the nitrogen atom. "Optionally substituted heterocyclylalkyl" refers to a heterocyclylalkyl radical, as defined above, wherein the alkylene chain of the heterocyclylalkyl radical is an optionally substituted alkylene chain, as defined above, and the heterocyclyl radical of the heterocyclylalkyl radical is an optionally substituted heterocyclyl radical, as defined above. "Heterocyclylalkenyl" refers to a radical of the formula -RdRh where Rd is an alkenylene chain as defined above and Rh is a heterocyclyl radical as defined above, and when the heterocyclyl is a nitrogen-containing heterocyclyl, the heterocyclyl may be attached to the alkenylene chain at the nitrogen atom. "Optionally substituted heterocyclylalkenyl’’ refers to a heterocyclylalkenyl radical, as defined above, wherein the alkenylene chain of the heterocyclylalkenyl radical is an optionally substituted alkenylene chain, as defined above, and the heterocyclyl radical of the heterocyclylalkenyl radical is an optionally substituted heterocyclyl radical, as defined above. "Heterocyclylalkynyl" refers to a radical of the formula -ReRh where Re is an alkynylene chain as defined above and Rb is a heterocyclyl radical as defined above, and when the heterocyclyl is a nitrogen-containing heterocyclyl, the heterocyclyl may be attached to the alkynylene chain at the nitrogen atom. "Optionally substituted heterocyclylalkynyl" refers to a heterocyclylalkynyl radical, 18 19 as defined above, wherein the alkynylene chain of the heterocyclyialkynyl radical is an optionally substituted alkynylene chain, as defined above, and the heterocyclyl radical of the heterocyclyialkynyl radical is an optionally substituted heterocyclyl radical, as defined above. "Heteroaryl" refers to a 5- to 14-membered ring system radical comprising hydrogen atoms, one to thirteen carbon atoms, one to six heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and at least one aromatic ring. A heteroaryl radical is commonly, but not necessarily, attached to the parent molecule via an aromatic ring of the heteroaryl radical. For purposes of this invention, the heteroaryl radical may be a monocyclic, bicyclic or tricyclic ring system, which may include spiro or bridged ring systems; and the nitrogen, carbon or sulfur atoms in the heteroaryl radical may be optionally oxidized and the nitrogen atom may be optionally quaternized. For purposes of this invention, the aromatic ring of the heteroaryl radical need not contain a heteroatom, as long as one ring of the heteroaryl radical contains a heteroatom. For example benzo-fused heterocyclyls, like 1,2,3,4-tetrahydroisoquinolin-7-yl, are considered a "heteroaryi" for the purposes of this invention. Examples of heteroaryl radicals include, but are not limited to, azepinyl, acridinyl, benzimidazolyl, benzindolyl, 1.3- benzodioxolyl, benzofuranyl, benzoxazolyl, benzothiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1H-benzo[b]azepinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyi, benzotriazolyi, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 3.4- dihydro-2H-benzo[b][1,4]dioxepinyl, cyclopenta[4,5]thieno[2,3-d]pyrimidinyl such as 6.7- dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 3.4- dihydro-2H-benzo[b][1,4]thiazinyi, 5,6-dihydrobenzo[/?]cinnolinyl, 7’,8’-dihydro-5'/-/-spiro[[1,3]dioxolane-2,6'-quinolinej-3’-yl, 6.7- dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazinyl, 2,3-dihydro-1 H-pyrido[2,3-ri][1,4]oxazinyl, 3’,4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-ri][1,4]oxazinyl, dihydropyridooxazinyi such as 3,4-dihydro-2H-pyrido[3,2-6][1,4]oxazinyl, dihydropyridothiazinyl such as 3,4-dihydro-2H-pyrido[3I2-b][1,4]thiazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo{3,2-c]pyridinyl, furopyrimidinyl, furopyridazinyl, furopyrazinyl, isothiazolyl, imidazolyl, imidazopyrimidinyljmidazopyridazinyl, imidazopyrazinyl, imidazo[1,2-a]pyridinyl, indazolyl, indolyi, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolinyl (isoquinolyl), indolizinyl, isoxazolyl, naphthyridinyl, 19 20 1,6-naphthyridinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6,68,7,8,9,10,1 Oa-octahydrobenzo[b]quinazolinyl, 3'-oxo-3',4'- dihydrospiro[cyclobutane-1,2'-pyndo[3,2-b][1,4]oxazinejyl, 7-oxo-5,6,7)8-tetrahydro-1,8-naphthyridinyl, 1-phenyl-1 H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthaiazinyl, phenanthridinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl (pyridyl), pyrido[3,2-d]pyrimidinyl, pyrido[3,4-cQpyrimidinyl, pyrazinyl, pyrimidinyi, pyridazinyl (pyridazyl), pyrrolyl, pyrrolopyrimidinyl, pyrroiopyridazinyl, pyrrolopyrazinyl, 2H-pyrido[3,2-b][1,4]oxazinonyl, 1H-pyrido[2,3-b][1,4]oxazinonyl, pyrrolopyridinyl such as 1 H-pyrrolo[2,3-b]pyridinyl, quinazolinyl, quinoxalinyl, quinolinyl, quinuclidinyl, tetrahydroquinolinyl, 5.6.7.8- tetrahydroquinazolinyl, 2,3,4,5-tetrahydrobenzoibloxepinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indolyl, 6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridinyi, 6.7.8.9- tetrahydro-5H-pyrido[3,2-c]azepinyl, 5.6.7.8- tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyi, ej.S^-tetrahydro-SH-cycloheptaH^lthienop.S-cQpyrimidtnyl, 5.6.7.8- tetrahydropyndo[4,5-c]pyridaztnyl, 7,8,9,9a-tetrahydro-5H-pyrido[2,3- e]pyrrolo[1,2-a][1,4]diazepin-10(11 H)-onyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, 1,2,3,4-tetrahydroisoquinolin-7-yl, triazinyl, thieno[2,3-d]pyrimidinyl, thienopyrimidinyl (e.g., thieno[3,2-d]pyrimidinyl), thieno[2,3-e]pyridinyl, thienopyridazinyl, thienopyrazinyl, and thiophenyl (thienyl).

Optionally substituted heteroaryl" refers to a heteroaryl radical, as defined above, which is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, haloalkynyl, oxo, thioxo, cyano, nitro, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R21-OR20, -R21-OC(O)-R20, -R21-N(R2O)2, -R21-C(O)R20, -R21-C(O)OR20 -R21-C(O)N(R20)2i -R21-N(R20)C(O)OR20, -R21-N(R20)C(O)R20, -R21-N(R2D)S(O)2R202, -R21-C(=NR2o)N(R2°)2, -R21-S(O)tOR20 (where t is 1 or 2), -R21-S(O)PR20 (where p is 0, 1 or 2), and -R21-S(O)2N(R20)2f where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally 20 21 substituted cycioalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20's, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heterocyclyl or an optionally substituted N-heteroaryl, and each R21 is independently a direct bond or a straight or branched alkylene or alkenylene chain. "N-heteroaryl" refers to a heteroaryl radical as defined above containing at least one nitrogen and where the point of attachment of the N-heteroaryi radical to the rest of the molecule may be through a nitrogen atom in the ΛΖ-heteroaryl radical or through a carbon atom in the N-heteroaryl radical. "Optionally substituted /V-heteroaryl" refers to an ΛΖ-heteroaryl, as defined above, which is optionally substituted by one or more substituents as defined above for optionally substituted heteroaryl. "Heteroarylalkyl" refers to a radical of the formula -RbR} where Rb is an alkylene chain as defined above and R is a heteroaryl radical as defined above, and when the heteroaryl is a nitrogen-containing heteroaryl, the heteroaryl may be attached to the alkylene chain at the nitrogen atom. "Optionally substituted heteroarylalkyl" refers to a heteroarylalkyl radical, as defined above, wherein the alkylene chain of the heteroarylalkyl radical is an optionally substituted alkylene chain, as defined above, and the heteroaryl radical of the heteroarylalkyl radical is an optionally substituted heteroaryl radical, as defined above. "Heteroarylalkenyl" refers to a radical of the formula -RdRj where Rd is an alkenylene chain as defined above and Rj is a heteroaryl radical as defined above, and when the heteroaryl is a nitrogen-containing heteroaryl, the heteroaryl may be attached to the alkenylene chain at the nitrogen atom. "Optionally substituted heteroarylalkenyl" refers to a heteroarylalkenyl radical, as defined above, wherein the alkenylene chain of the heteroarylalkenyl radical is an optionally substituted alkenylene chain, as defined above, and the heteroaryl radical of the heteroarylalkenyl radical is an optionally substituted heteroaryl radical, as defined above. "Heteroarylalkynyl" refers to a radical of the formula -ReRj where Re is an alkynylene chain as defined above and Rj is a heteroaryl radical as defined above, and when the heteroaryl is a nitrogen-containing heteroaryl, the heteroaryl may be attached to the alkynylene chain at the nitrogen atom. "Optionally substituted heteroarylalkynyl" refers to a heteroarylalkynyl radical, as 21 22 defined above, wherein the aikynylene chain of the heteroarylalkynyl radical is an optionally substituted aikynylene chain, as defined above, and the heteroaryl radical of the heteroarylalkynyl radical is an optionally substituted heteroaryl radical, as defined above. "Hydroxyalkyl" refers to an alkyl radical as defined above which is substituted by one or more hydroxy radicals (-OH). "Hydroxyalkenyl" refers to an alkenyi radical as defined above which is substituted by one or more hydroxy radicals (-OH). "Hydroxyalkenyl" refers to an alkynyl radical as defined above which is substituted by one or more hydroxy radicals (-OH).

Certain chemical groups named herein may be preceded by a shorthand notation indicating the total number of carbon atoms that are to be found in the indicated chemical group. For example; C7-C12alkyl describes an alkyl group, as defined above, having a total of 7 to 12 carbon atoms, and C4-C12cycloalkylalkyl describes a cycloalkylalkyl group, as defined above, having a total of 4 to 12 carbon atoms. The total number of carbons in the shorthand notation does not include carbons that may exist in substituents of the group described. "Stable compound" and "stable structure" are meant to indicate a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. "Mammal’' means any vertebrate of the class Mammalia. Humans and domestic animals, such as cats, dogs, swine, cattle, sheep, goats, horses, rabbits, and the like are a particular focus. Frequently, for purposes of this invention, the mammal is a human. "Optional" or "optionally" means that the subsequently described event or circumstances may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not. For example, "optionally substituted aryl" means that the aryl radical may or may not be substituted and that the description includes both substituted aryl radicals and aryl radicals having no substitution. However, when a first functional group is described as "optionally substituted," and in turn, substituents on the first functional group are also "optionally substituted" and so forth, for the purposes of this invention, such iterations for a radical to be optionally substituted are limited to three. Thus, groups described as substituents on the third iteration are not themselves optionally substituted. For example, if an R group herein is defined as being "optionally substituted aryl" (the first iteration) and the optional substituents for the "optionally substituted aryl" include "optionally substituted heteroaryl" 22 23 (the second iteration) and the optional substituents for the "optionally substituted heteroaryl" include "optionally substituted cycloalkyl" (the third iteration), the optional substituents on the cycloalkyl can not be optionally substituted. "Para" for the purposes of this invention refers to the position of a substituent on 5 a phenyl or a six-membered heteroaryl ring relative to another substituent on the ring; the relative position being 1,4-substitution. That is, starting from one substituent as being attached to a first atom of the phenyl or six-membered heteroaryl ring and, counting atoms in the ring from the first atom, another substituent is on atom 4 of the phenyl or the six-membered heteroaryl ring, the substituents' relative orientation about 10 the phenyl or six-membered heteroaryl ring is "para." For example, a compound of formula (I), as set forth above in the Summary of the Invention, depicted below as a compound of formula (la-1), where Rs is on a first atom of the phenyl ring, and the nitrogen bearing R1 is on the fourth atom, then Rs and the nitrogen bearing R1 are "para" in relative orientation. 15 R‘ "Meta" for the purposes of this invention refers to the position of a substituent on a phenyl or a six-membered heteroaryl ring relative to another substituent on the ring; the relative position being 1,3-substitution. That is, starting from one substituent as being attached to a first atom of the phenyl or six-membered heteroaryl ring and, 20 counting atoms in the ring from the first atom, another substituent is on the third atom of the pheny or the six-membered heteroaryl ring, the substituents’ relative orientation about the phenyl or the six-membered heteroaryl ring is "meta." For example, a compound of formula (I), as set forth above in the Summary of the Invention, depicted below as a compound of formula (la-1c), where R2 is on a first atom of the phenyl ring, 25 and the nitrogen bearing hydrogen is on a third atom, then R2 and the nitrogen bearing hydrogen are "para" in relative orientation. R‘ 5a

H 23 24 "Pharmaceutically acceptable excipient" includes without limitation any adjuvant, carrier, excipient, glidant, sweetening agent, diluent, preservative, dye/colorant, flavor enhancer, surfactant, wetting agent, dispersing agent, suspending agent, stabilizer, isotonic agent, solvent, or emulsifier which has been approved by the United States 5 Food and Drug Administration as being acceptable for use in humans or domestic animals. "Pharmaceutically acceptable salt" includes both acid and base addition salts. "Pharmaceutically acceptable acid addition salt" refers to those salts which retain the biological effectiveness and properties of the free bases, which are not biologically or 10 otherwise undesirable, and which are formed with inorganic acids such as, but not limited to, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as, but not limited to, acetic acid, 2,2-dichloroacetic acid, adipic acid, algintc acid, ascorbic acid, aspartic acid, benzenesulfonic acid, benzoic acid, 4-acetamidobenzoic acid, camphoric acid, camphor-10-sulfonic acid, capric acid, 15 caproic acid, caprylic acid, carbonic acid, cinnamic acid, citric acid, cyclamic acid, dodecylsulfonic acid, ethane-1,2-disulfonic acid, ethanesulfonic acid, 2-hydroxyethanesulfonic acid, formic acid, fumaric acid, galactaric acid, gentisic acid, glucoheptonic acid, gluconic acid, glucuronic acid, glutamic acid, glutaric acid, 2-oxo-glutaric acid, glycerophosphoric acid, glycolic acid, hippuric acid, isobutyric acid, lactic 20 acid, lactobionic acid, lauric acid, maleic acid, malic acid, malonic acid, mandeiic acid, methanesulfonic acid, mucic acid, naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, 1-hydroxy-2-naphthoic acid, nicotinic acid, oleic acid, orotic acid, oxalic acid, palmitic acid, pamoic acid, propionic acid, pyroglutamic acid, pyruvic acid, salicylic acid, 4-aminosalicylic acid, sebacic acid, stearic acid, succinic acid, tartaric acid, 25 thiocyanic acid, p-toluenesulfonic acid, trifluoroacetic acid, undecylenic acid, and the like. "Pharmaceutically acceptable base addition salt" refers to those salts which retain the biological effectiveness and properties of the free acids, which are not biologically or otherwise undesirable. These salts are prepared from addition of an inorganic base or an organic base to the free acid. Salts derived from inorganic bases include, but are not 30 limited to, the sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Preferred inorganic salts are the ammonium, sodium, potassium, calcium, and magnesium salts. Salts derived from organic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic 35 amines and basic ion exchange resins, such as ammonia, isopropylamine, 24 25 trimethylamine, diethylamine, triethylamine, tripropylamine, diethanolamine, ethanolamine, 2-dimethylaminoethanol, 2-diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, benethamine, benzathine, ethylenediamine, glucosamine, methylglucamine, 5 theobromine, triethanolamine, tromethamine, purines, piperazine, piperidine, /V-ethylpiperidine, polyamine resins and the like. Particularly preferred organic bases are isopropylamine, diethylamine, ethanolamine, trimethylamine, dicyciohexylamine, choline and caffeine. A "pharmaceutical composition" refers to a formulation of a compound of the 10 invention and a medium generally accepted in the art for the delivery of the biologically active compound to mammals, for example, humans. Such a medium includes all pharmaceutically acceptable carriers, diluents or excipients therefor. "Therapeutically effective amount" refers to that amount of a compound of the invention which, when administered to a mammal, for example a human, is sufficient to 15 effect treatment, as defined below, of a disease or condition of interest in the mammal, preferably a human. The amount of a compound of the invention which constitutes a "therapeutically effective amount" will vary depending on the compound, the disease or condition and its severity, and the age of the mammal to be treated, but can be determined routinely by one of ordinary skill in the art having regard to his own 20 knowledge and to this disclosure. "Treating" or "treatment" as used herein covers the treatment of the disease or condition of interest in a mammal, for example a human, having the disease or condition of interest, and includes: (i) preventing the disease or condition or one of its manifestations or 25 symptoms from occurring in a mammal, in particular, when such mammal is predisposed to the condition but has not yet been diagnosed as having it; (ii) inhibiting the disease or condition, i.e., arresting its development or one or more of its manifestations or symptoms; (iii) relieving the disease or condition, i.e., causing regression of the disease 30 or condition or one if its manifestations or symptoms; or (iv) stabilizing the disease or condition or one of its manifestations or symptoms.

As used herein, the terms "disease" and "condition" may be used interchangeably or may be different in that the particular malady or condition may not have a known 35 causative agent (so that etiology has not yet been worked out) and it is therefore not yet 25 26 recognized as a disease but only as an undesirable condition or syndrome, wherein a more or less specific set of symptoms have been identified by clinicians.

The compounds of the invention, or their pharmaceutically acceptable salts may contain one or more asymmetric centres and may thus give rise to enantiomers, diastereomers, and other stereoisomeric forms that may be defined, in terms of absolute stereochemistry, as (R)- or (S)- or, as (D)- or (L)- for amino acids. The present invention is meant to include all such possible isomers, as well as their racemic and optically pure forms. Likewise, all tautomeric forms of the specifically described structures are also intended to be included. Optically active (+) and (-), (R)- and (S)-, or (D)- and (L)-isomers may be prepared using chiral synthons or chiral reagents, or resolved using conventional techniques, such as HPLC using a chiral column. When the compounds described herein contain olefinic double bonds or other centres of geometric asymmetry, and unless specified otherwise, it is intended that the compounds include both E and Z geometric isomers. Similarly, with reference to bicycltc ring systems present in particular embodiments, such moieties often may have substituents attached in an "endo" or "exo" relative configuration. The stereochemical descriptor "endo" refers to a bridge substituent that points toward the larger of the two remaining bridges, if the substituent points toward the smaller remaining bridge, it is referred to as an "exo" substituent.

When used herein in a formula to indicate a chemical bond and not to indicate the point of attachment of a substituent to the rest of a molecule (as shown in Tables 2 and 3 below), the bond symbol indicates that the chemical bond may be attached in any relative or absolute configuration, for example, the chemical bond may be in an endo or exo relative configuration. Similarly, the chemical bond may be attached in the R or S absolute configuration. A "stereoisomer" refers to a compound made up of the same atoms bonded by the same bonds but having different three-dimensional structures, which are not interchangeable. The present invention contemplates various stereoisomers and mixtures thereof and includes "enantiomers", which refers to two stereoisomers whose molecules are nonsuperimposeable mirror images of one another. A "tautomer" refers to a proton shift from one atom of a molecule to another atom of the same molecule. The present invention includes tautomers of any said compounds. "Atropisomers" are stereoisomers resulting from hindered rotation about single bonds where the barrier to rotation is high enough to allow for the isolation of the conformers (Eliel, E. L.; Wilen, S. H. Stereochemistry of Organic Compounds; Wiley &amp;amp; Sons: New York, 1994; Chapter 14). Atropisomerism is significant because it introduces 26 27 an element of chirality in the absence of stereogenic atoms, The invention is meant to encompass atropisomers, for example in cases of limited rotation around the single bonds emanating from the core pyrimidine structure, atropisomers are also possible and are also specifically included in the compounds of the invention. 5 The chemical naming protocol and structure diagrams used herein are a modified form of the I.U.P.A.C. nomenclature system wherein the compounds of the invention are named herein as derivatives of the central core structure, i.e., the pyrimidine-2-amine structure. For complex chemical names employed herein, a substituent group is named before the group to which it attaches. For example, cyclopropylethyl comprises an ethyl 10 backbone with cyclopropyl substituent. In chemical structure diagrams, all bonds are identified, except for some carbon atoms which are assumed to be bonded to sufficient hydrogen atoms to complete the valency.

For example, a compound of formula (I), as set forth above in the Summary of the 15

Invention, wherein n is 0, m is 1, is phenyl, R1 is hydrogen, R2 is fluoro at the meta position, R4 is 6-(4-acetylpiperazin-1 -yl)pyridin-3-yl and Rs is (1S,4$)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl at the para position relative to the nitrogen bearing hydrogen, i.e., a compound of the following formula (wherein the positions of the pyrimidinyl ring are indicated):

<img img-format="tif" img-content="drawing" file="IL207609AD00025.tif" id="idf0005" />

20 is named herein as 4-(6-(4-acetylpiperazin-1 -yl)pyridin-3-yl)-N-(3-fluoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

EMBODIMENTS OF THE INVENTION

One aspect of the invention are compounds of formula (I), as set forth above in the Summary of the Invention, as an isolated stereoisomer or a mixture thereof, or as a 25 pharmaceutically acceptable salt thereof. Of this aspect, certain embodiments of the compounds of formula (I) are preferred. 27 28

In one embodiment, ring A in the compounds of formula (I) is a phenyl or pyridinyl ring. Of this embodiment, one embodiment is wherein R5 is a bridged N-heterocyclyl. Of this embodiment, a preferred embodiment is wherein the bridged ^/-heterocyclyl is selected from the group consisting of:

<img img-format="tif" img-content="drawing" file="IL207609AD00026.tif" id="idf0006" />

<img img-format="tif" img-content="drawing" file="IL207609AD00027.tif" id="idf0007" />

, where each R5a is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally 10 substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 15 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)2N(R8)R7, and -R8-S(O)tR6 where t is 1 or 2 and each R6, R7, R9 and R9 is as defined above in the Summary of the Invention for compounds of 20 formula (I), and where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl, or two R20's, together with the 25 common nitrogen to which they are both attached, form an optionally substituted 28 29 N-heterocyclyl or an optionally substituted N-heteroaryl.

Another embodiment of the compounds of formula (I), as set forth above in the

Summary of the Invention, are compounds wherein R5 is a bridged N-heterocyclyl, or wherein a R4 substituent is a bridged N-heterocyclyl, or wherein R5 and a R4 substitutent 5 are both bridged N-heterocycyls. In certain embodiments of this invention, R5 is a bridged N-heterooyclyl.

In the compounds of formula (I) wherein R5 is a bridged A/-heterocyclyl or the R4 substituent is a W-heterocyclyl, R5 and the R4 substituent need not be attached to ring A or R4, respectively, via a ring nitrogen of the bridged N-heterocyclyl, but rather can be 10 attached via a ring carbon, for example. In some embodiments, a bridged /V-heterocyclyl as R5 or as a R4 substituent is fused to another ring, part of a spiro ring system or both.

In certain embodiments, a bridged A/-heterocyclyl as R5 or as a R4 substituent, alone or as part of a larger fused, spiro or combination ring system, comprises a substructure geometry selected from the group consisting of [4.4.0], [4.3.0], [4.2.0], [4.1.0], [3.3.0], 15 [3.2.0], [3.1.0], [3.3.3], [3.3.2], [3.3.1], [3.2.2], [3.2.1], [2.2.2] and [2.2.1]. in one embodiment, the bridged N-heterocyclyl as R5 or as an R4 substituent, independently if more than one, is selected from the group consisting of:

<img img-format="tif" img-content="drawing" file="IL207609AD00028.tif" id="idf0008" />

29 30

<img img-format="tif" img-content="drawing" file="IL207609AD00029.tif" id="idf0009" />

5a and

<img img-format="tif" img-content="drawing" file="IL207609AD000210.tif" id="idf0010" />

i5a , where each RSa is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted 5 cycioalkylalkyl, optionally substituted cyctoalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted 10 heteroarylalkynyl, -R8-OR6, -RB-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R8)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O),R6 where t is 1 or 2 and each R6, R7, R8 and R9 is as defined above in the Summary of the Invention for compounds of formula (I) and where each R20 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted 15 cycioalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryi and optionally substituted heteroarylalkyl, or two R20ls, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heterocyclyl or an optionally substituted /V-heteroaryl. 20 In a particular embodiment, Rs is a bridged A/-heterocyclyl and R4 is a heteroaryl optionally substituted with a bridged N-heterocyclyl. In exemplary compounds of the invention for this embodiment, R5 is a bridged N-heterocyclyl containing an additional nitrogen, R4 is a 5- or 6-membered heteroaryl and n is 0. In a specific embodiment, R5 and the nitrogen bearing R1 are in a para regiochemical relationship with each other and 25 R4 is selected from pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl triazolyl, tetrazinyl, tetrazolyl, pyrazolyl, pyrrolyl, imidazolyl and pyrazolyl. In certain embodiments, R4 is substituted with an amino-containing group, e.g., -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a or -R8-N(R6a)-R9-OR7a, where each R6a, R7a, R8 and R9 are as described above in the Summary of the Invention for compounds of formula (I), or R4 is substituted with an 30 optionally substituted heterocyclyl, e.g. an optionally substituted piperidinyl, optionally substituted piperazinyi, optionally substituted morpholinyl, and optionally substituted thiomorpholinyl. In some examples of this embodiment, R4 is substituted with a bridged 30 31 /V-heterocyclyl. In further examples, ring A and/or R4 are substituted with up to three additional substituents selected from the group consisting of halo, alkyl, haloalkyl, cyano, nitro, hydroxy, -OR25, -N(R25)2, -C(O)OR25, -C(O)N(R25)2and combinations thereof; where each R25 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl and cycloalkylalkyl.

Another embodiment of the invention is a compound of formula (I), as set forth above in the Summary of the Invention, according to formula (la):

<img img-format="tif" img-content="drawing" file="IL207609AD000211.tif" id="idf0011" />

wherein: n is 0, 1 or 2; m is 0,1 or 2; Y is selected from the group consisting of =C(R6)- and =N-; R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, -R8-C(O)OR6, -R9-N(R6)R7 and -R9-OR8; each R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; each R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of aryl and heteroaryl, where the aryl and the heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, N-heterocyclyl, A/-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(RSa)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R6-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, 31 32 optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted aralkyl, and where the W-heterocyclyl, the A/-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R5-N(Re)R7, -RB-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted A/-heteroaryl or an optionally substituted AZ-heterocyclyl; R5 is an N-heterocyclyl, wherein a nitrogen atom in the W-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R8, -R8-C(O)OR8, -R9-N(R8)R7, -R8-C(O)N(R8)R7, -R8-C(N=R8)N(Rs)R7, -R8-S(O)2N(R8)R7, and -R8-S(O),R6 (where t is 1 or 2); and a carbon atom in the A/-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, haloalkynyl, oxo, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -Re-C(O)OR6, -R9-N(R6)R7, -Rb-C(O)N(R8)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)PR8 (where p is 0, 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 32 33 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyciylalkyl, optionally substituted heterocydylalkenyl, optionally substituted 5 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; 10 each Ra is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; and each R9 is independently selected from the group consisting of an optionally substituted 15 straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; provided at least one of Rs and a substituent on R4 is a bridged N-heterocyclyl; as an isolated stereoisomer or a mixture thereof, or as a pharmaceutically acceptable 20 salt thereof.

One embodiment of the compounds of formula (la) is a compound of formula (la), as set forth above, wherein: m is 0 or 1; R2, when present, is in a meta position relative to the nitrogen bearing R1; and 25 R5 is in the para position relative to the nitrogen bearing R1.

One embodiment of the compounds of formula (la) is a compound of formula (la), as set forth above, wherein: n is 0 or 1; and R3, when present, is at the 5-position of the pyrimidinyl ring. 30 One embodiment of the compounds of formula (la) is a compound of formula (la), as set forth above, wherein: m is 0 or 1; n is 0 or 1; R2, when present, is in a meta position relative to the nitrogen bearing R1; 35 R3, when present, is at the 5-position of the pyrimidinyl ring: and 33 34 R5 is in the para position relative to the nitrogen bearing R1.

One embodiment of the invention is a compound of formula (I), as set forth above in the Summary of the invention, according to formula (la-1): R‘ wherein: n is 0, 1 or 2; m is 0, 1 or 2; R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkenyl, optionally substituted cycioalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, -R8-C(O)OR6, -R9-N(R6)R7 and -R9-OR6; each R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; each R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of aryl and heteroaryl, where the aryl and the heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, /V-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-Rs-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycioalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted aralkyl, and where the /V-heterocyclyl, the V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, 34 35 alkyl, halo and optionally substituted aryl, and when any RSa and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; 5 R5 is an /V-heterocyclyl, wherein a nitrogen atom in the A/-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, haloaikenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, 10 optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted 15 heteroarylalkynyl, -R8-OR6, -R9-C(O)R6, -R8-C(O)OR6, -R9-N(R8)R7, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)tR6 (where t is 1 or 2); and a carbon atom in the A/-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloaikenyl, haloalkynyl, oxo, optionally substituted aryl, 20 optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 25 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R’-OR6, -R8-C(O)R8, -Re-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-S(O)2N(R8)R7, and -R8-S(O)PR8 (where p is 0, 1 or 2); each R8 and each R7 is independently selected from the group consisting of hydrogen, 30 alkyl, alkenyl, alkynyl, haloalkyl, haloaikenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 35 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted 35 36 heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R8 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heteroaryl or an optionally substituted N-heterocyclyl; 5 each R8 is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; and each R9 is independently selected from the group consisting of an optionally substituted 10 straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; provided at least one of R5 and a substituent on R4 is a bridged /V-heterocyclyl.

Of the compounds of formula (la-1), as set forth above, one embodiment is a 15 compound selected from the following formulae: 36 37

<img img-format="tif" img-content="drawing" file="IL207609AD000212.tif" id="idf0012" />

wherein: each n is 0, 1 or 2; each R2a is independently selected from the group consisting of hydrogen, optionally 5 substituted alkyl, halo, cyano and -OR6; each R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; each R4 is independently selected from the group consisting of aryl and heteroaryl, 37 38 10 15 20 25 30 where the aryl and the heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, A/-heteroaryl, aryl, -R8-OR63, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)RSa, -R8-C(O)OR6a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R8a)-R9-N(R6a)R7a, -R8-N(R8a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R8a)S(O)2R7a, -R8-N(R8a)C(O)-R8-N(R8a)R7a, and -R8-N(R8a)-R9-N(R6a)S(O)2R7a, where each R6a and R73 is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted aralkyl, and where the A/«heterocyclyl, the A/-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R8, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl, and when any R63 and R73 are bonded to a common nitrogen, R63 and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally substituted /V-heterocyclyl; each RSa is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroaryialkynyi, -R8-OR8, -R8-C(O)R8, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R8)N(R6)R7, -Rb-S(O)2N(R8)R7, and -RB-S(O),R8 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted 35 38 39 heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; 5 each R8 is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; and each R9 is independently selected from the group consisting of an optionally substituted 10 straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain.

Of this embodiment, one embodiment is a compound selected from the formulae above wherein: 15 eachnisOorl; each R4 is independently selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 H-benzo[6]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][ 1,4]oxazinyl, 3,4-dihydro-2/-/-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro- 20 2W-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrah yd ro-5/7- pyrido[2,3-bjindolyl, y.e.Q^a-tetrahydro-SW-pyridop.S-eJpynOlotl^-a][1,4]diazepin-10(11/7)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from 25 the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N- heteroary), aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where the 30 /V-heterocyclyl, the /V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R9-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, 35 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 39 40 cycloaikyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 5 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heteroaryl or an optionally substituted /V-heterocyclyl; 10 R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloaikyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both 15 attached, may form an optionally substituted A/-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. 20 One embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 a):

<img img-format="tif" img-content="drawing" file="IL207609AD000213.tif" id="idf0013" />

wherein: n is 0 or 1; 25 R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, 30 benzo[b]azepinyl, 2,3,4,5-tetrahydro-1W-benzo[b]azepinyl, 3,4-dihydro-2H- 40 41 benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2’-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2/7-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5/7-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5H-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, indoiyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, N-heterocyclyl, N-heteroaryl, aryl, -R8-ORea, -R8-S(O)pR8a (where p is 0,1 or 2), -R8-C(O)R8a, -R8-C(O)OR6a,-R8-C(O)N(R8a)R7a, -R8-N(R8a)R7a, -R8-N(R8a)-R9-N(R8a)R7a, -R8-N(R8a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R0a)S(O)2R7a, -R8-N(R0a)C(O)-R8-N(R0a)R7a, and -R8-N(R8a)-R9-N(R8a)S(O)2R7a, where the A/-heterocyclyl, the ΛΖ-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; RSa is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -RS-C(O)R6, -R8-C(O)OR6, -R9-N(R8)R7, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)2N(Rs)R7, and -R8-S(O),R6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted 41 42 heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N- hetero ary I or an optionally substituted A/-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, 5 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally 10 substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-1 a), as set 15 forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and 20 haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of alkyl, haloalkyl, cyano, -R8-OR6a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a and -R8-N(R6a)-R9-OR7a; R5a is independently selected from the group consisting of hydrogen, alkyl, optionally 25 substituted cycloalkyl, -R8-C(O)R6 and -R0-S(O)tR6 (where t is 1 or 2); each R6 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted 30 aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; 35 R6a and R7a are each independently selected from the group consisting of hydrogen, 42 43 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N- hetero ary I or an optionally substituted /V-heterocyclyl; each Rb is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1a), as set forth above, selected from the group consisting of: 4-(6-( N, /V-dimethylamino)pyridin-3-yl)-/V-(3-methyl-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(/7, /V-dimethylamino)pyridin-3-yi)-5-methyl-A/-(3-methy 1-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(A/,/V-dimethylamino)pyridin-3-yl)-5-trifluoromethyl-/V-(3-methyl-4-((1S,4S)-5-methyl- 2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(/7, /7-dimethylamino)pyridin-3-yl)-5-fluoro-/7-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(/7,/V-dimethylamino)pyridin-3-yl)-5-fluoro-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6«(A/,/V-dimethylamino)pyridin-3-yl)-5-methyl-/V-(3-fluoro-4-((1$l4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(/7,/7-dimethylamino)pyridin-3-yl)-/7-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-/7-(3-methyl-4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-/V-(4-((1S,4$)-5-methyl-2,5- diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-y!)ethyl)aminopyridin-3-yl)-/V-(3-fluoro-4-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(cyclohexylamino)pyridin-3-yl)-/7-(3-methyi-4-((1S14S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6~(cyclohexylamino)pyridin-3-yl)-/V-(3-fluoro-4-((1$,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 43 44 4-(6-(benzylamino)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicycfo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(benzylamino)pyridin-3-yl)-N-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 5 4-(6-(cyclohexylamino)pyridin-3-yl)-A/-(3-tifluoromethyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-N-(3-tifluoromethyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pynmidin-2-amine; 4-(6-cyanopyndin‘3-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabieyclo[2.2.1 ]heptan-2 10 yl)phenyl)pyrimidin-2-amine; 4-(5-cyanopyndin-3-yl)-A/-(3-methyl-4((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1jheptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-aminopyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-ethylcarbonyl-2,5- diazabicyclo[2,2.1]heptan-2-y1)pheny1)pyrimidin-2-amine; 15 4-(6-aminopyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-ethoxypyridin-3-yl)~/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclQ[2.2J]heptan- 2-yl)phenyl)pyrirnidin-2-amine; 4-(6-ethoxypyndin-3-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2 20 yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-A/-(4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyc(oi2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 25 4-(6-(propylamino)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-ethylcarbonyl- 2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-dimethylamino)propylaminopyndin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-30 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-{6-(3-methylbutyl)aminopyridin-3-yl)-N-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2,2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3,3-dimethylbutyl)aminopyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 35 4-(6-(2-methoxyethyl)(methyl)aminopyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5- 44 45 di azabi cy clo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(propylamino)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methylsulfonyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(trifluoromethyl)pyridin-4-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2l5- 5 diazabtcyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-chloro-4-((1S,4S)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-chioro-4-((1$,4S)-5-acetyl-2,5« diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 10 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2~amine; and 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-cyclopentyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Of this embodiment, another embodiment is a compound of formula (la-1 a), as 15 set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and 20 haloalkyl; R4 is pyridinyl substituted by an A/-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1]heptanyl and thiamorpholinyl, where the W-heterocyclyl is optionally substituted by one or more substituents selected from the group 25 consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7 and -R8-S(O),R6 (where t is 1 30 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally 35 substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted 45 46 heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 a), as set forth above, selected from the group consisting of: 4-(6-(morpholin-4-yl)pyndin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morphoiin-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo(2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(4-acetylpiperazin«1 -yl)pyridin-3-yl)-N-(3-fluoro-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methy!-4-((1$(4S)-5-ethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-((ethylamino)carbonyl)-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/\/-(3-methyi-4-((1$,4S)-5-(2,2,2-trifluoroethyl)-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morphortn-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-(cyclopropyl)methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine; 4-(3-fluoro-2-(morpholin-4-yl)pyridin-4-yl)-N-(3-fluoro-4-((1S,4S)-5-methyl-2l5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-methyl-6-(morpho!in-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-((1$,4$)-5-methyl-2,5- diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2~amine; 4- (5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-methy 1-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 5- methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methy 1-2,5- diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 5-methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1Rl4R)-5-methyl-2,5- 46 47 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yi)pyridin-3-yl)-/V-(3-fluoro-4-((1fi,4R)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-tifluoromethyl-4-((1S,4S)-5-methyl-2&gt;5- 5 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyndin-3-yl)-N-(3-cyano-4-((1S,4S)-5-acetyl-2l5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/\/-(3-cyano-4-((1S,4$)-5-methylsulfonyl-2,5- diazabicyclo[2.2,1]heptan-2-yl)phenyi)pyrimidin-2-amine; 10 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-cyano-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-cyano-4-((1$,4S)-5-cyclopentyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- 15 yl)phenyi)pyrimidin-2-amine; 4-(6-(c/s-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(dimethylamino)methyimorpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1Sl4S)-5- methyi-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 20 4-(6-(piperidin-1 -yl)pyridin-3-yi)-N-(3-methyl-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-(aminocarbonyl)piperidin-1-yl)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methylsulfonyl-2)5-25 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-ethylcarbonyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyndin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-amidino-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 30 4-(6-(morpho(in-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-isobutyl-2,5- diazabicycio[2.2,1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(1,4-oxazepan-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1 S, 4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-((1 S,4S)-2-oxa-5-azabicycio[2.2.1 ]heptan-5-yl)pyridin-3-yl)-N-(3-methyl-4-((1 S,4S)-35 5-methyi-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 47 48 4-(6-(thiamorpholin-4-yl)pyridirb3-yl)-N-(3-methyi-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2~amine; and 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-cyc!opropyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yf)-N-(3-chloro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/\/-(3-chloro-4-((1S,4S)-5-(methylsulfonyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine; 4-(6-(™οΓρΚοΙίη-4-γΙ)ργπάΐη-3-γΙ)-/ν-(3-οΜοπ&gt;4-((18,48)-5-3θβΙγΙ-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-chloro-4-((1S,4S)-5-(1-methylethyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pynmidin-2-amine; 4-(6-((1 S,4S)-2-oxa-5-azabicycio[2.2.1]heptan-5-yl)pyridin-3-yl)-/V-(3-methyI-4-((1 S, 48)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1jheptan-2-yl)phenyl)pyrimidin-2-amine; and 4-(6-((1 ft,4ft)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyridin-3-yl)-/V-(3-methyi-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2,2.13heptan-2-yl)phenyl)pynmidin-2-amine.

Another embodiment is a compound of formula (la-1 a), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of-R8-C(O)R6a, -R8-C(O)OR6a, -R8-C(O)N(RSa)R7a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-N(R6a)-R9-N(R6a)S(O)2R7a, -R8-N(R8a)C(O)R7a, -R8-N(R6a)S(O)2R7s, -R8-N(R6a)C(O)-R8-N(R6a)R7a and tetrazolyl; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycioalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7 and -R8-S(O)tR6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, 48 49 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyi, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted 5 heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylaikenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heteroaryl or an 10 optionally substituted N-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common 15 nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted A/-heteroaryl or an optionally substituted /V-heterocyclyl; each Rs is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and 20 R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 a), as set forth above, selected from the group consisting of: 4-(6-(methylaminocarbonyl)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2l5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 25 4-(5-((morpholin-4-yl)carbonyl)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2,2.1]heptan-2-y!)phenyl)pyrimidin-2-amine. Bis TFA salt; 4-(5-(methyl)sulfonylpyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2l5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-((2-(cyclopropylsulfonyl)aminoethyl)-amino)pyridin-3-yl)-/V-(3-methyl-4-((1S, 45)-5- 30 methyl-2,5-diazabicyclo[2.2.1]heptan-2-y!)phenyl)pyrimidin-2-amine; 4-(6-( 1 H-tetrazol-5-yl)pyridin-3-y l)-A/-(3-methyl-4(( 1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 4-(6-(acetamido)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 35 4-(6-(2-(morpho!in-4-yl)acetamido)pyridin-3-yl)-/\/-(3-methyl-4-((1S,4$)-5-methyl-2,5- 49 50 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(morphoiin-4-yl)acetamido)pyridin-3-yl)-A/-(4-((1S,4S)-5-methyl-2,5- diazabicycloi2.2.1]heptan-2-y!)phenyl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-N-(3-fluoro-4-((1S,4S)-5-methyl-2,5- 5 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(acetamido)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-ethylcarbonyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(3-methyl-4-((lS,4$)-5-methyl-2,5- diazabicycloi2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine; 10 4-(6-(2-(dimethylamino)acetamido)-pyridin-3-yl)-A/-(3-methy!-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; and 4-(6-(methylsulfonylamino)pyridin-3-yl)-N-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; and 4-(5-(1-methylethoxy)carbonylpropyl-6-aminopyridin-3-yl)-W-(3-methyl-4-((1S,4S)-5- 15 methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 a), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally 20 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[5]azepinyl, 2,3,4,5-tetrahydro-1 tf-benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2H- 25 benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2- b][1,4]oxazinyl, 3,4-dihydro-2/7-pyrido[3,2-b][1,4]thiazinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5H-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, and 3,4-dihydro-2H-pyrido[3,2-b][1,4joxazinyl, each optionally substituted by one or more substituents independently selected from 30 the group consisting of alkyl and oxo; RSa is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8~C(O)N(R6)R7, -R8-C(N=Rs)N(R6)R7, -R8-S(O),R6 (where t is 1 or 2), and -R8-S(O)2N(R6)R7; 35 each R6 and each R7 is independently selected from the group consisting of hydrogen, 50 51 alkyl, alkenyl, alkynyl, haloalkyl, haloaikenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted 5 heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an 10 optionally substituted /V-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 a), as set forth above, selected from the group consisting of: 15 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyi-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-fluoro-4-((1S,4S)-5- methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-fluoro-4- 20 ((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4- ((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4joxazin-7-yl)-/V-(3-methyl-4- ((1 $,4S)-5-(ethylcarbonyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2- 25 amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/V-pyrido[3,2-0][1l4]oxazin-7-yl)-A/-(3-methy!-4- ((1S,4$)-5-(methylsulfonyl)-2,5-diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2- amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido{3,2-0)(1,4]oxazin-7-yl)-/V-(3-methyl-4-30 ((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine; 4-(3’-oxo-3,l4,-dihydrospiro[cyclobutane-1,2,-pyrido[3,2-b][1,4]oxazine]-7'-yl)-A/-(3-methyl- 4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3,-oxo-3',4,-dihydrospiro[cyclobutane-1,2,-pyrido[3,2-b][1,4]oxazine]-7,-yl)-/V-(3-methyl-4-((1 Sl4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 35 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2B-pyrido[3,2-0][1,4]oxazin-7-yl)-N-(3-methyl-4- 51 52 ((1 S,4S)-5-(aminosuifonyi)-2,5-diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2 amine; 4-(7-oxo-5,6,7,8-tetahydro-1,8-naphthyridin-3-yl)-V-(3-methyl-4-((1S,4S)-5-methy!-2l5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 5 4-(2,2-dimethyi-3-oxo-3,4-dthydro-2H-pyrido[3,2-b][1,4Joxazin-7-yl)-V-(3-cyano-4- ((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methy!-4- ((1R,4R)-5-methy!-2,5-diazabicyc!o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2R-pyrido[3)2-b][1,4)oxazin-7-yl)-V-(3-fluoro-4-10 ((1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine; 4-(3,4-dihydro-2H-pyrido[3,2-b]i1l4]oxazin-7-yl)-V-(3-methyi-4-((1Sl4S)-5-methy!-2,5-diazabicyclo[2.2.1 ]heptan-2-y!)phenyl)pyrimidin-2-amine; 4-(3,4-dihydro-2H-pyrido[3,2-bJ[1,4]oxazin-7-yl)-V-(3-f!uoro-4-((1S, 4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 15 4-(3,4-dihydro-2/-/-pyrido[3,2-b][1,4}oxazin-7-yl)- V-(3-tifluoromethyl-4-((1 S,4S)-5-methyl· 2.5- diazabicyclo[2.2.1}heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2H-benzo[bj[ 1,4]oxazin-3(4H)-on-6-y!)-/V-(3-fluoro-4-(( 1 S,4S)-5-methy I-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2,4-trimethyi-3-oxo-3)4-dihydro-2H-pyrido[3,2-bj[1)4]oxazin-7-yl)-V-(3-methyi-4- 20 ((1Sl4S)-5-methyl-2,5-diazabicyclo{2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2,4-trimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-V-(3-fluoro-4- ((1 $,4S)-5-methyl-2,5-diazabicyclo[2,2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-rnethyl-4- ((1S,4$)-5-methyl-2,5-diazabicyclo[2.2.1jheptan-2-yl)phenyl)pyrimidin-2-amine; 25 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b]i1,4}oxazin-7-yl)-V-(4-((1 S,4S)-5- methyl-2,5-diazabicyc!o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3)4-dihydro-2/7-pyrido[3,2-b][1l4]oxazin-7-yi)-V-(3-trifluoromethyl- 4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-methyl-3,4-dihydro-2W-pyridoi3,2-b][1,4]oxazin-7-yl)-V-(4-((1$,4S)-5-methyl-2,5- 30 diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine; 4-(4-methyl-3)4-dihydro-2H-pyrido[3)2-b][1,4]oxazin-7-yi)-V-(3-methyl-4-((1S,4S)-5- methylsulfonyi-2,5-diazabicyclo[2.2.13heptan-2-yl)phenyl)pyrimidin-2-amine; 4-{3-oxo-3,4-dihydro-2H-pyrido[3,2-b]t1)4]oxazin-7-yi)-V-(3-methy!-4-((1S,4S)-5-methy!- 2.5- diazabicyclo[2.2.1 ]heptan-2-y!)phenyl)pyrimidin-2-amine; 35 4-(7-oxo-5,6,7,8-tetahydro-1,8-naphthyridin-3-yl)-V-(3-methyl-4-((1 S,4$)-5- 52 53 methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3,4-dihydro-2H-benzo[b][1l4]thiazin-7-yl)-A/-(4-((1S,4S)-5-methyl-2,5- diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2/-/-benzo[t»][1,4loxazin-7-yl)-A/-(3-methyl-4-((1S,4S)- 5 5-methyl-2,5-diazabicycto[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-/\/-(3-methy 1-4-(( 1S,45)-5-methylsulfonyl-2I5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-oxo-2,3,4,5-tetrahydro-1W-benzo[/?]azepin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl- 2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 10 4-(2-oxo-2,3,4,5-tetrahydro-1 H-benzo[b]azepin-7-yi)-/V-(3-methyl-4-((1 S,4S)-5- methylsulfonyl-2,5-diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2H-pyrido[3,2-b]i1,4]oxazin-7-yl)-/V-(3-methyl-4- ((1 S,45)-5-(1 -methylethyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 15 4-(2,2-dimethyl-3-oxo-3,4-dihydiO-2H-pyrido[3,2-0][1,4]oxazin-7-yl)-/V-(3-methyl-4- ((1 5,45)-5-cycfopropyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-6][1,4]oxazin-7-yl)-A/-(3-chloro-4- ((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 20 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-chloiO-4-

((IS^SJ-S-imethylsulfonyO-Z.S-diazabicyclop^.lJheptan-a-ylJphenyOpyrimidin-Z amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-d][1,4]oxazin-7-yi)-N-(3-methyl-4-((1 5,45)-5-cyclopentyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2- 25 amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4- ((15,4S)-5-acetyt-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6,7,8,9-tetrahydro-5/7-pyrido[2,3-bjindol-3-yl)-A/-(3-methyl-4-((15,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 30 4-(6,7,8,9-tetrahydro-5/7-pyrido[2,3-b]indol-3-yl)-N-(3-methyl-4-((1S,4S)-5- (methylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yi)phenyi)pyrimidin-2-amine; 4-(7,8,9,9a-tetrahydro-5W-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11 H)-on-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.13heptan-2-yl)phenyl)pyrimidin-2-amine; 35 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yi)-A/-(3-cyano-4-((1S,4S)-5· 53 54 methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-oxo-2,3,4l5-tetrahydro-1/-/-benzo[b]azepin-7-yl)-/V-(3-cyano-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3l4-dihydro-2H-benzo[bj[1,4]thiazin-7-yl)-A/-(3-cyano-4-((1Sl4S)-5-methyl-2,5- 5 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; and 4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 a), as set forth above, wherein: 10 nisOorl; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; 15 R4 is phenyl substituted by one or more substituents selected from the group consisting of alkyl, haloalkyl, -R8-OR6a, -R8-N(R6a)R7a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, N-heteroaryl and N-heterocyclyl, where the N-heterocyclyl and the N-heteroaryl are each independently optionally substituted by one or more substituents selected 20 from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 and -R8-S(O)tR6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, 25 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 30 heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N- hetero ary I or an optionally substituted N-heterocyclyl; 35 R6a and R7a are each independently selected from the group consisting of hydrogen, 54 55 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both 5 attached, may form an optionally substituted /V-heteroaryl or an optionally substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 a), as 10 set forth above, selected from the group consisting of: 4-(4-(/V,N-dimethylamino)pheny!)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(A/,A/-dimethylamino)phenyl)-W-(3-fluoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 15 4~(4-(4,5-dihydrothiazol-2-ylcarbamoyl)phenyl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yt)phenyl)pyrimidin-2-amine; 4-(4-(1,1-dimethylethyl)phenyl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine; 4-(4-(morpholin-4-yl)phenyl)-N-(3-fluoro~4-((1S,4S)-5-methyl-2,5-20 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.TFA salt; 4-(4-((methyl)aminocarbonylmethyl)-phenyl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.TFA salt; 4-(4-((cyclopropyl)aminocarbonyl-methyl)phenyl)-/\/-(3-methyl-4-((1S,4$)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 25 4-(4-(5-(4-dimethylaminophenyl)oxazol-2-yl)phenyl)-/V-(3-methyl-4-((1S,4$)-5-methyl-2l5-diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(i-butylcarbonylamino)phenyl)-/\/-(3-fluoro-4-((1$,4S)-5-methyl-2I5- diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine; 4-(4~(f-butylcarbonylamino)phenyl)-/V-(3-methyl-4-((1Sl4S)-5-methyl-2,5-30 diazabicyclo[2.2.1}heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-N-(3-methyl-4-((1Sl4S)-5~methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 35 4-(4-(methylsuifonylamino)phenyl)-/\/-(3-fluoro-4-((1Sl4S)-5-methyl-2,5- 55 56 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(methylsulfonylamino)phenyl)-/\/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(3-cyclopropylureido)phenyl)-/\/-(4-((1S,4$)-5-methyl-2,5-diazabicyclo[2.2.1]heptan- 5 2-yl)phenyl)pyrimidtn-2-amine; 4-(4-( 1 -ethoxyethyl)phenyl)-A/-(3-methyl-4-(( IS, 4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(1-ethoxyethyl)phenyl)-A/-(3-fluoro-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 lheptan-2-yl)phenyl)pyrimidin-2-amine; and 10 4-(4-(trifluoromethyl)phenyl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyf)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 a), as set forth above, wherein: n is 0 or 1; 15 R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of benzimidazolyl, imidazo[1,2-a]pyridinyl, 20 indolyi, indolinyl, pyrazolyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1/7-pyrrolo[2,3- bjpyridinyI and thiazolyl, each independently substituted by one or more substituents selected from the group consisting of alkyl, cyano, oxo, -R8-OR6a, -R8-N(R6a)R7a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)C(O)R7a, -R8-N(R8a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, aryl, N-heteroaryl and /V-heterocyclyl, where the 25 aryl, the /V-heterocyclyl and the /V-heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 30 and -R8-S(O),R6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally 35 substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted 56 57 heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; and each R6 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 a), as set forth above, selected from the group consisting of: 4-(1/-/-indol-6-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine;; 4-(1/-/-pyrrolo[2,3-b]pyridin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2l5-diazabicyclo[2.2,1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1W-pyrrolo[2,3-b]pyridin-5-yl)-/V-(3-fluoro-4-((1$,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1/-/-pyrrolo[2,3-b]pyridin-5-yl)-A/-(3-methyl-4-((1S,4S)-5-(2,2,2-tnfluoroethyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-(cyclopropyl)methyl-2l5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(morpho!in-4-yl)pyrimidin-5-yl)-/V-(4-((1$,4S)-5-methyl-2,5- diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-/V-(3-fluoro-4-((1S,4S)-5-rnethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-((cyc!opropyl)carbonylamino)-pyrimidin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyc!o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 57 58 4-(2-(propyl)aminopyrimidin-5-yl)-/\/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(propyl)aminopyrimidin-5-yl)-N-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 5 4-(imidazo[1,2-a]pyridin-6-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-methoxy-1H-indol-2-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1 -(3-chlorophenyl)-1 H-pyrazol-4-yl)-A/-(3-methy 1-4-((1 S,4S)-5-methyl-2,5-10 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1-methylbenzimidazol-6-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-cyano-1 H-indol-2-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 15 4-(1 -(4-fluorophenyl)-1 /-/-pyrazo!-4-yl)-A/-(3-methy 1-4-((1 S,4$)-5-methyl-2,5- diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-oxoindolin-5-yl)-/\/-(3-methyl-4((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(5-(3-methylpiperidin-1-yl)pyrazin-2-yl)-A/-(3-fluoro-4-((1Sl4S)-5-methyl-2,5-20 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(diethylamino)thiazol-4-yl)-/V-(3-methyl-4-((1S,4S)-5-rnethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(diethylamino)thiazol-4-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yt)phenyl)pyrimidin-2-amine; 25 4-(1/7-pyrrol-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(1 H-py rrol-3-yl)-N-(4-((1 S,4S)-5-methyl-2,5-diazabicycloi2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1 /7-pyrrol-3-yl)-A/-(3-trifluoromethyl-4-(( 1 S,4S)-5-methyl-2,5-diazabicycloI2.2.1 Jheptan 30 2-yl)phenyl)pyrimidin-2-amine; 4-(2-(dimethylamino)thiazol-4-yl)-N-(3~methyl-4-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(dimethylamino)thiazol-4-yl)-W-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1jheptan-2-yl)phenyl)pyrimidin-2-amine; 35 4-(5-(morpholin-4-yl)pyrazin-2-yl)-/V-(3-methyl-4-((1S,4$)-5-methyl-2,5- 58 59 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-(morpholln-4-yl)pyrazin-2-yl)-/V-(3-fluoro-4-((1SI4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1-(pyridin-4-yl)-1/-/-indol-5-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1-(pyridin-4-yl)-1H-indol-5-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1-(pyridin-4-yl)-1/-/-indol-5-yl)-A/-(3-methyl-4-((1S,4S)-5-ethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine; and 4-(1 -(pyridin-4-yl)-1 W-indol-5-yl)-/V-(3-methyl-4-((1 S,4S)-5-isobutyl-2,5- diazabicycto[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 b):

<img img-format="tif" img-content="drawing" file="IL207609AD000214.tif" id="idf0014" />

wherein; n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[bj[1,4]oxazinyl, benzoib]azepinyi, 2,3,4,5-tetrahydro-1 H-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b](1,4jthiazinyl, 3',4'-dihydrospiro[cyclobutane-1, 2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4joxazinyl, 3,4-dihydro-2H-pyrido[3,2-£&gt;][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5H-pyndo[2,3-b]indolyl, 7l8,9,9a-tetrahydro-5H-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11W)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, /V-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, 59 60

<img img-format="tif" img-content="drawing" file="IL207609AD000215.tif" id="idf0015" />

-R8-N(R8a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R8a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where the N-heterocyclyl, the A/-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)RS, -R8-N(R6)R7, -Rs-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R8 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 10 15 20 25 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted ΛΖ-heteroaryl or an optionally substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (Mb), as set 30 forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and 35 haloalkyl; 60 61 R4 is pyridinyl substituted by one or more substituents selected from the group consisting of alkyl, cyano, -R8-OR6a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a and -R8-N(R6a)-R9-OR7a; R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; RSa and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted A/-heteroaryl or an optionally substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1b), as set forth above, selected from the group consisting of: 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-A/-(3-methyl-4-((1$,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(propylamino)pyridin-3-yl)-/\/-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-dimethylamino)propylaminopyridin-3-yl)-A/-(3-methyl-4-((1$,4S)-5-oxa-2-azabicyclo[2.2.1jheptan-2-yl)phenyl)pyrimidin-2-amine; and 4-(6-(2-methoxyethyl)(methyl)aminopyridin-3-yl)-A/-(3-methyl-4-((1S,4$)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (Mb) wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; 61 62 R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an ZV-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, pyrrolidinyl, oxazepanyl, 5-oxa-2- 5 azabicyclo[2,2.1]heptanyl and thiamorpholinyl, where the A/-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R9-N(R6)R7, -R9-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, 10 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 15 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; and 20 each R9 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 b), as set forth above, selected from the group consisting of: 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4$)-5-oxa-2- 25 azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-c/s-216-dimethylmorpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-y!)phenyl)pyrimidin-2-amine; 4-(6-( 1,4-oxazepan-4-yl)pyridin-3-yi)-A/-(3-methyl-4-((1 S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; and 30 4-(6-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)-N-(3-methyl-4-((1 S,4S)- 5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 b), as set forth above, wherein: n is 0 or 1; 35 R2a is independently selected from the group consisting of hydrogen, optionally 62 63 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting 5 of -R8-C(O)R6a, -R8-C(O)N(R6a)R7a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-N(R6a)-R9-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and tetrazolyl; R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted 10 cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted 15 heteroarylalkenyl, and optionally substituted heteroarylalkynyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common 20 nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and 25 R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 b), as set forth above, selected from the group consisting of: 4-(6-((2-(cyclopropylsulfonyl)aminoethyl)-amino)pyridin-3-y!)-W-(3-methyl-4-((1S,4$)-5~ oxa-2-azabicyc!o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 30 4-(5-(methyl)suifonylpyridin-3-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-(methyl)suifonylpyridin-3-yl)-A/-(3-tifluoromethyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; and 4-(6-(acetamido)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2- 35 yl)phenyl)pyrimidin-2-amine. 63 64

Another embodiment is a compound of formula (la-1 b), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2W-benzo[b][1,4]thiaziny1, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][ 1,4]oxazinyl, 3,4-dihydro-2/7-pyrido[3,2-b][1,4]thiazinyl and 3,4-dihydro-2H-pyrido[3,2-0][1,4]oxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; and R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylaikenyl, and optionally substituted heteroarylalkynyl; A specific embodiment of this embodiment is a compound of formula (la-1 b), as set forth above, selected from the group consisting of: 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-0][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-W-(3-methyl-4-((1S,4$)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; and 4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-methyl-4-((1S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 b), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and 64 65 haloalkyl; R4 is selected from the group consisting of benzimidazolyl, imidazo[1,2-a]pyridinyl, indolyl, indolinyl, pyrazoiyi, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1/7-pyrrolo[2,3-b]pyridinyl and thiazolyl, each independently substituted by one or more substituents selected from the group consisting of alkyl, cyano, oxo, -R8-OR6a, -R8-N(Rea)R7a, -R8-C(O)N(R8a)R7a, -R8-N(R8a)C(O)R7a, -R8-N(R8a)S(O)2R7a, -R8-N(R8a)C(O)-R8-N(R8a)R7a, aryl, W-heteroaryl and N-heterocyclyl, where the aryl, the /V-heterocyclyl and the A/-heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R8)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted /7-heteroaryl or an optionally substituted /V-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 b), as set forth above, selected from the group consisting of: 4-(1 /7-pyrrolo[2,3-b]pyridin-5-yl)-/V-(3-methyl-4-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine; and 65 66 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyc!o[2.2.1 ]heptan-2-yl)phenyl)pyrimldin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 c):

<img img-format="tif" img-content="drawing" file="IL207609AD000216.tif" id="idf0016" />

wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; 10 R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 H-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2’-pyrido[3,2- 15 b][1,4]oxazinyl, 3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H- pyrido[3,2-b][ 1,4]thiazinyl, imidazo[1,2-ajpyridinyl, 6,7,8,9-tetrahydro-5/7-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5B-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11B)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each 20 optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, N-heterocyclyl, N-heteroaryl, aryl, -R8-OR8a, -R8-S(O)pR6a (where p is 0,1 or 2), -R8-C(O)R6a, -R8-C(O)ORea,-R8-C(O)N(R6a)R7a, -R8-N(R8a)R7a, -R8-N(R6a)-R9-N(R8a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R8a)S(O)2R7a, 25 -R8-N(R8a)C(O)-R8-N(R8a)R7a, and -R8-N(R8a)-R9-N(R8a)S(O)2R7a, where the /V-heterocyclyl, the N-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; 30 R5a is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, 66 67 haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted 5 heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R®)N(R6)R7, 10 -R8-S(O)2N(R6)R7, and -Ra-S(O){R6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally 15 substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which 20 they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyciyi; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and 25 optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an 30 optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (!a-1c), as set forth above, wherein: n is 0 or 1; 35 R2a is independently selected from the group consisting of hydrogen, optionally 67 68 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting 5 of alkyl, cyano, -R6-OR6a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a and -R8-N(R6a)-R9-OR7a; R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 and -R8-S(O)tR6 (where t is 1 or 2); R6a and R7a are each independently selected from the group consisting of hydrogen, 10 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally 15 substituted N-heterocyclyl; each R6 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted 20 aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyciylalkynyi, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; 25 each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 c), as set forth above, selected from the group consisting of: 30 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3-y!)phenyl)pyrimidin-2-amine; 4-(6-(cyclohexylamino)pyridin-3-yl)-N-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabtcyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-N-(3-fiuoro-4-(1,5,7-trimethyl-3,7- 35 diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 68 69 4-(4-(dimethylamino)phenyl)-N-(3-fluoro-4-(1,5,7-trimethy!-3,7-diazabicyclo[3.3.1 ]nonan- 3-yl)phenyl)pyrimidin-2-amine; 4-(6-(benzyl)pyridin-3-yl)-/V-(3-methy!-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3- yl)phenyl)pyrimidin-2-amine; 5 4-(6-(benzyl)pyridin-3-yl)-/V-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicycio[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-(1)5l7-trimethyl-3,7-10 diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-dimethylamino)propylaminopyrjdin-3-yl)-/V-(3-methy!~4-(1 .S.Z-tnmethyt-S,?-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidtn-2-amine; and 4-(6-(2-methoxyethyl)(methyl)aminopyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine. 15 Another embodiment is a compound of formula (la-1 c), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; 20 R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an /V-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1]heptanyl and thiamorpholinyl, where the /V-heterocyclyl is 25 optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -RS-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, 30 -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R8)R7 and -R8-S(O)tR6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyi, haloalkyl, haloalkenyl, haloaikynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, 35 optionally substituted aralkyl, optionally substituted aralkenyl, optionally 69 70 substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroaryialkenyl, and optionally substituted heteroaryialkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted Λ+heteroaryl or an optionally substituted N-heterocyclyl; each R9 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched aikylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 c), as set forth above, selected from the group consisting of: 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-/\/-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-y!)-/\/-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicycio[3.3.1]nonan-3-yl)pheny!)pyrimidin-2-amine; and 4-(6-((2S,6R)-2,6-dimethy(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 c), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2W-benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2’-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-. pyrido[3,2-b][1,4]thiazinyl and 3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; RSa is independently selected from the group consisting of hydrogen, alky!, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, 70 71 -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O),R6 (where t is 1 or 2), and -R8-S(O)2N(R8)R7; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 5 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted 10 heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N- hetero ary I or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an 15 optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 c), as set forth above, selected from the group consisting of: 4-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(1,5,7-trimethyf-3l7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 20 4-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-fluoro-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1 ]nonan-3-yi)phenyl)pyrimidin-2-amine; and 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-(1,5,7- trimethy!-3,7-diazabicycio[3.3.1]nonan-3-y!)phenyl)pyrimidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a 25 compound according to formula (la-1 d):

<img img-format="tif" img-content="drawing" file="IL207609AD000217.tif" id="idf0017" />

wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally 30 substituted alkyl, halo, cyano and -OR6; 71 72 R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 H-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-£&gt;][ 1,4]oxazinyl, 3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a] pyridinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5/7-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, indoiyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl pyrazinyl, pyrimidinyl, pyrrolyl, 1 W-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, N-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R8a, -R8-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R8-N(R8a)R7a, -R8-N(R8a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R8a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R8a)R7a, and -R8-N(R6a)-R9-N(R8a)S(O)2R7a, where the ΛΖ-heterocyclyl, the N-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R6a is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR8, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R8)N(R8)R7, -R8-S(O)2N(R6)R7, and -Rs-S(O),R6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, 72 73 optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, 10 15 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-1 d), as set 20 forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and 25 haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of alkyl, cyano, -R8-OR6a, -R8-N(R6a)R7a, -RB-N(R6a)-R9-N(R6a)R7a and

<img img-format="tif" img-content="drawing" file="IL207609AD000218.tif" id="idf0018" />

R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 30 35 and -R8-S(O),R6 (where t is 1 or 2); each R6 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloaikenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted 73 74 heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; 5 R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both 10 attached, may form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. 15 A specific embodiment of this embodiment is a compound of formula (la-1d), as set forth above, which is 4-(6-aminopyridin-3-yl)-/V-(4-(8-methyl-3,8-diazabicyclo[3.2.1 ]octan-3-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 d), as set forth above, wherein: 20 n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted aikyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; 25 R4 is pyridinyl substituted by an N-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1 Jheptanyl and thiamorpholinyl, where the A/-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally 30 substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7 and -R8-S(O),R6 (where t is 1 or 2); 35 each R6 and each R7 is independently selected from the group consisting of hydrogen, 74 75 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 d), as set forth above, selected from the group consisting of: 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)pyrimidin-2-amine; and 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3- yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1d), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of -R8-C(O)R6a, -R8-C(O)N(R6a)R7a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-N(R8a)-R9-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and tetrazolyl; RSa is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R8)R7 and -R8-S(O)tR6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 75 76 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, RSa and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted A/-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 d), as set forth above, selected from the group consisting of: 4-(6-(methylsulfonyiamino)pyridin-3-yl)-/V-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3- yl)phenyl)pyrimidin-2-amine; 4-(4-(acetamido)phenyl)-/V-(4-(8-methyl-3,8-diazabicyclo[3.2.i]octan-3- yl)phenyl)pyrimidin-2-amine; 4-(6-(methylsulfonylamino)pyridin-3-yl)-/V-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1joctan-3-yl)pheny!)pyrimidin-2-amine; and 4-(4-(/-butylcarbonylamino)phenyl)-N-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1]octan- 3-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1d), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and 76 77 haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2H~benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H- 5 pyrido[3,2-b][1,4]thiazinyl and 3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; RSa is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, 10 -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)tR6 (where t is 1 or 2), and -R8-S(O)2N(R6)R7; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, 15 optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylaikenyl, and optionally substituted 20 heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. 25 A specific embodiment of this embodiment is a compound of formula (la-1 d), as set forth above, selected from the group consisting of: 4-(2l2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b]i1,4]oxazin-7-yl)-A/-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)pyrimidin-2-amine; and 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-methyl-4-(8- 30 methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)pyrimidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 e): 77 78

<img img-format="tif" img-content="drawing" file="IL207609AD000219.tif" id="idf0019" />

wherein: n is 0 or 1; 10 15 20 25 R is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 H-benzo[b]azepinyl, 3,4-di hydro-2 H-benzo[b][1,4]thiazinyl, 3’,4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2/-/-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2/7-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5W-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5W-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1/-/-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR8a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a,-R8-C(O)N(R8a)R7a, -R8-N(R6a)R7a, -R8-N(R8a)-R9-N(R8a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R8a)S(O)2R7a, -R8-N(R8a)C(O)-R8-N(R8a)R7a, and -R8-N(R8a)-R9-N(R8a)S(O)2R7a, where the /V-heterocyclyl, the N-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -Ra-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloaikenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 30 78 79 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an 5 optionally substituted W-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyciylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common 10 nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted A/-heteroaryl or an optionally substituted A/-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and 15 each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-1e) wherein: R4 is pyridinyl substituted by one or more substituents selected from the group consisting of alkyl, cyano, -R8-OR6a, -R8-N(R6a)R7a, -R8-N(R8a)-R9-N(R6a)R7a and -R8-N(R6a)-R9-OR7a; and 20 R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyciylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R8a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both 25 attached, may form an optionally substituted N-heteroaryl or an optionally substituted /7-heterocyclyl. A specific embodiment of this embodiment is a compound of formula (la-1 e), as set forth above, which is 4-(6-cyanopyridin-3-yl)-N-(3-methyl-4-(7-azabicyclo[2.2.1]heptan-7-yl)phenyl)pyrimidin-2-amine. 30 Another embodiment is a compound of formula (la-1e), as set forth above, wherein: n is 0 or 1; RZa is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; 35 R3, when present, is independently selected from the group consisting of alkyl, halo and 79 80 haloalkyl; R4 is pyridinyl substituted by an A/-heterocyclyl selected from the group consisting of morpholinyl, piperazinyi, piperidinyl, oxazepanyl, 5-oxa-2-azabicycloi2.2.1]heptanyl and thiamorpholinyl, where the N-heterocyclyl is 5 optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R’-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R8 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 10 cycloalkyl, optionally substituted cycioalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted 15 heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R8 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an 20 optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 e), as set forth above, which is 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(7-azabicyclo[2,2.1]heptan-7-yl)phenyl)pyrimidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a 25 compound according to formula (la-1f):

<img img-format="tif" img-content="drawing" file="IL207609AD000220.tif" id="idf0020" />

wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally 30 substituted alkyl, halo, cyano and -OR6; 80 81 R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4Joxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 W-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3’,4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4joxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2/-/-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-bjindolyl, 7l8,9,9a-tetrahydro-5H-pyrido[2,3-e]pyrrolo[1l2-a][1,4]diazepin-10(11H)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -Re-S(O)pR8a (where p is 0, 1 or 2), -R8-C(O)R8a, -R8-C(O)OR8a,-R8-C(O)N(R8a)R7a, -R8-N(R8a)R7a, -R8-N(R8a)-R9-N(R8a)R7a, -R8-N(R8a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R8a)S(O)2R7a, -R8-N(R8a)C(O)-R8-N(R8a)R7a, and -R8-N(R8a)-R9-N(R8a)S(O)2R7a, where the /V-heterocyclyl, the /V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R8, -R8-N(R8)R7, -R8-C(O)N(R8)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common 81 82 nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted W-heteroaryl or an optionally substituted W-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an 5 optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-1f), as set forth above, wherein: n is 0 or 1; 10 R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by -R8-OR6a; 15 or R4 is pyridinyl substituted by an W-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1 Jheptanyl and thiamorpholinyl, where the W-heterocyclyl is optionally substituted by -C(O)R6; and each R6 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, 20 alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 25 heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted W-heteroaryl or an optionally substituted W-heterocyclyl; 30 R6a is selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; and R8 is independently selected from the group consisting of a direct bond and an optionally 35 substituted straight or branched alkylene chain. 82 83 A specific embodiment of this embodiment is a compound of formula (la-1f), as set forth above, selected from the group consisting of: 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4- yl)phenyl)pyrimidin-2-amine; 5 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((R)-1,4-diazabicyclo[3,2.1]octan-4-yl)phenyl)pyrimidin-2-amine; and 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((S)-1,4-diazabicyclo[3.2.1]octan-4-10 yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1f), as set forth above, wherein; n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally 15 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of benzimidazolyl, imidazo[1,2-a]pyridinyl, indolyl, indolinyl, pyrazolyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3- 20 bjpyridinyi, 3,4-dihydro-2H-pyrido[3,2-b]{1,4]oxazinyl and thiazolyl, each independently substituted by one or more substituents selected from the group consisting of alkyl, cyano, oxo, -R8-OR6a, -R8-N(R6a)R7a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, aryl, N-heteroary! and A/«heterocyclyl, where the aryl, the N-heterocyclyl and the N- 25 heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 and -R8-S(O)tR6 (where t is 1 or 2); 30 each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted 35 heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 83 84 heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heteroaryl or an 5 optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloaikyi, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common 10 nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally substituted /V-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. 15 A specific embodiment of this embodiment is a compound of formula (la-1f), as set forth above, selected from the group consisting of: 4-(2-oxoindolin-5-yl)-/V-(3-methyl-4-(1,4-diazabicyc!o[3.2.1]octan-4~yl)phenyl)pyrimidin-2- amine; (1-methylbenzimidazol-6-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4- 20 yl)phenyl)pyrimidin-2-amine; 4-(imidazo[1,2-a]pyridin-6-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2.1 joctan-4- yl)phenyl)pyrimidin-2-amine; and 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2.1 ]octan-4-yl)phenyl)pyrimidin-2-amine. 25 Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (fa-1 g):

<img img-format="tif" img-content="drawing" file="IL207609AD000221.tif" id="idf0021" />

wherein: n is 0 or 1; 30 R2a is independently selected from the group consisting of hydrogen, optionally 84 85 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazotyl, benzo[b][1,4joxazinyl, benzo[b]azeplnyl, 2,3,4,5-tetrahydro-1 /-/-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][ 1,4]oxazinyl, 3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5W-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11 H)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 /7-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N- 6a heteroaryl, aryl, -Ra-ORaa, -Ra-S(O)pR6a (where p is 0, 1 or 2), -Ra-C(O)R -R9-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R6-N(R6a)R7a, -R9-N(R6a)-R9-N(R6a)R7a, -R9-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R8a)-R9-N(R6a)S(O)2R7a, where the /V-heterocyclyl, the A/-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -Rs-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and 85 86 optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted /V-heteroaryl or an optionally substituted N-heterocyclyl; each R9 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

In one embodiment the compound has formula (la-1 g), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an /V-heterocyctyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1jheptanyl and thiamorpholinyl, where the /V-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, aikyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; and each R9 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 g), as set forth above, selected from the group consisting of: 86 87 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2.2]nonan-4-yl)phenyl)pyrimidin-2-amine; and 4-(6-((1 S,4S)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-yl)pyridin-3-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2.2]nonan-4-yl)phenyl)pynmidin-2-amine.

Another embodiment is a compound of formula (la-1 g), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of-R8-C(O)R6a, -R9-C(O)N(R6a)R7a, -R8-S(O)pR6a (where p is 0,1 or 2), -R8-N(R6a)-R9-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and tetrazolyl; R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; R63 and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 g), as set forth above, which is 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-/\/-(3-methy!-4-(1)4- 87 88 diazabicyclo[3.2.2]nonan-4-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 g), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]thiaziny1, 3',4’-dihydrospiro[cyclobutane-1,2'-pyndo[3,2-b][1,4]oxazinyl, 3,4-dihydro-2/7-pyrido[3,2-bj[1,4]thiazinyl and S^-dihydro^H-pyrido^Y-bJlI^Joxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; and R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl. A specific embodiment of this embodiment is a compound of formula (la-1g), as set forth above, which is 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.2jnonan-4-yl)phenyl)pyrimidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 h):

<img img-format="tif" img-content="drawing" file="IL207609AD000222.tif" id="idf0022" />

wherein: n is 0 or 1; R28 is independently selected from the group consisting of hydrogen, optionally 88 89 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 /-/-benzo[b]azepinyl, 3,4-dihydro-2/7-benzo[b][1,4]thiazinyl, 3',4'-dihydrospiroicyclobutane-1 ,2'-pyrido[3,2-b][1,4]oxaztnyl, 3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2B-pyrido[3,2-bj[1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indolyl, 718,9,9a-tetrahydro-5W-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, indolyi, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0,1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(Rea)-R9-N(R8a)S(O)2R7a, where the N-heterocyclyl, the N-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)RS, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyciylalkyl, optionally substituted heterocydylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyciylalkyl, optionally substituted heteroaryl, and 89 90 optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted W-heteroaryl or an optionally substituted W-heterocyclyl; 5 each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

In one embodiment the compound has formula (la-1 h), as set forth above, wherein: 10 nisOorl; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; 15 R4 is pyridinyl substituted by an W-heterocyctyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1 Jheptanyl and thiamorpholinyl, where the W-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally 20 substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally 25 substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which 30 they are both attached, form an optionally substituted W-heteroaryl or an optionally substituted W-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 h), as 35 set forth above, which is 4-(6-(morpholin-4-yl)pyridin-3-yl)-W-(3-methyl-4-((1 S,4R)-2- 90 91 azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1 h), as set forth above, wherein: n is 0 or 1; 5 R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and ~ORS; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl: R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, 10 benzo[b)[1,4]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3',4’- dihydrospiro[cyciobutane-1 .Z-pyridop^-bHI ,4]oxazinyl, 3,4-di hydro-2 W-pyrido[3,2-b][1,4]thiazinyl and 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; and 15 R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycioalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted 20 heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl. A specific embodiment of this embodiment is a compound of formula (la-1 h) which is 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-P][1,4]oxazin-7-yl)-/V-(3-methyl- 25 4-((1 S,4ft)-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrtmidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 i):

<img img-format="tif" img-content="drawing" file="IL207609AD000223.tif" id="idf0023" />

wherein: 30 n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally 91 92 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, 5 benzo[b]azepinyl, 2,3,4,5-tetrahydro-1H-benzo[b]azepinyl, 3,4-dihydro-2H- benzo[t&gt;][1,4Jthiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazinyl, 3f4-dihydro-2H-pyrido[3,2-t&gt;][1,4Joxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][ 1,4]thiazinyl, imidazo[1,2-alpyridinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5/-/-pyrido[2,3-e]pyrrolo[1,2- 10 a][1,4]diazepin-10(11W)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-/)]pyridinyl1 and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R6-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, 15 -R8-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where the /V-heterocyclyl, the /V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of 20 -C(O)R6, -R8-N(R6)R7, -R®-C(O)N(Re)R7, alkyl, halo and optionally substituted aryl; R5a is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally 25 substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted 30 heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O),R6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 35 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, 92 93 optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-1 i), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an /V-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azablcyclo[2.2.1]heptanyl and thiamorpholinyl, where the /V-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(R8)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; RSa is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7 and -R8-S(O)tR6 (where t is 1 or 2); 93 94 each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally 5 substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which 10 they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 i), as 15 set forth above, selected from the group consisting of: 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1 ]heptan-5-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(2-methylsulfony!-2-azabicyclo[2.2.1 ]heptan-6-yl)phenyl)pyrimidin-2-amine; 20 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine, and 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6- yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-1i), as set forth above, 25 wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and 30 haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, benzo[bj[1,4]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyI, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4jthiazinyl and 3,4-dihydro-2B-pyrido[3,2-b][1,4]oxazinyl, each 35 optionally substituted by one or more substituents independently selected from 94 95 the group consisting of alkyl and oxo; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -Re-C(O)N(Re)R7, -R8-C(N=R6)N(Re)R7, -Re-S(O),R8 (where t is 1 or 2), and -R8-S(O)2N(R6)R7; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 i), as set forth above, selected from the group consisting of: 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-y!)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-y!)-W-(4-(2- methylsulfonyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine; and 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(4-(2- methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yl)phenyl)pyrimidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 j): 95 96 10 15 20

<img img-format="tif" img-content="drawing" file="IL207609AD000224.tif" id="idf0024" />

wherein n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR8; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[bj[1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 W-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiaziny!, TA'-dihydrospiroIcyclobutane-l ,2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2W-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5/7-pyrido[2,3-b]indolyl, 7,8l9,9a-tetrahydro-5H-pyridoi2,3-e]pyrrolo[1l2-a][1,4]diazepin-10(11H)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyi, pyrimidinyl, pyrrolyl, 1/-/-pyrrolo[2,3-bjpyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR8a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R6-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where the 25 /V-heterocyclyl, the /V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R5)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 30 96 97 heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted /V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-1j), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an /V-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1]heptanyl and thiamorpholinyl, where the ZV-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(RS)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted 97 98 heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted W-heteroaryl or an optionally substituted W-heterocyclyl; and 5 each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1j), as set forth above, which is 4-(6-(morphoiin-4-yl)pyridin-3-yl)-W-(3-methyl-4-((6R,9S)-6,9-methanooctahydro-1W-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrimidin-2-amine. 10 Another embodiment is a compound of formula (la-1 j), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; 15 R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 W-benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2/7-benzo[b][1,4]thiazinyl, 3’,4'-dihydr0spiroicyclobutane-1,2'-pyrido[3,2- 20 d][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazinyl and 3,4-dihydro-2W- pyrido[3,2-b][1,4]oxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; and R6 is selected selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally 25 substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally 30 substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl. A specific embodiment of this embodiment is a compound of formula (la-1j) selected from the group consisting of: 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2W-benzo[b][1l4]oxazin-7-yl)-W-(3-methyl-4-((6Rl9S)- 6,9-methanooctahydro-1W-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrimidin-2-amine; 35 4-(2-oxo-2,3,4l5-tetrahydro-1/7-benzo[b]azepin-7-yl)-W-(3-methyl-4-((6R,9S)-6,9- 98 99 methanooctahydro-1H-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3,4-dihydro-2W-benzo[d][1,4]thiazin-7-yl)-N-(3-methyl-4-((6R,9S)-6,9- methanooctahydro-1H-pyrido[1,2-a]pyrazin-2-yl)phenyl)pynmidin-2-amine. Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-1 k): 5a wherein n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[6][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 H-benzo[b]azepinyl, 3,4-dihydro-2/7-benzo[b][1,4]thiazinyl, 3‘,4’-dlhydrospiro[cyclobutane-1 ,2'-pyrido[3,2-d][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-d][1,4]oxazinyl, 3,4-dihydro-2/7-pyrido[3,2-d][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-d]indolyl, 7,8,9,9a-tetrahydro-5W-pyrido[2,3-e]pyrrolo(1,2-a][1,4]diazepin-10(11/7)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrroloi2,3-0]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, N-heterocyclyl, N-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR8a (where p is 0,1 or 2), -R8-C(O)R8a, -R8-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R8a)-R9-N(R8a)R7a, -R8-N(R8a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R8a)C(O)-R8-N(R8a)R7a, and -R8-N(R8a)-R9-N(R8a)S(O)2R78, where the /V-heterocyclyl, the A/-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R9-N(R6)R7, -R®-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, 99 100 haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycioalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted ’ heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR8, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R8)R7, -R8-C(N=R6)N(R8)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)tR6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycioalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted V-heteroaryl or an optionally substituted V-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycioalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted V-heteroaryl or an optionally substituted V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-1k), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally 100 101 substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an /V-heterocyclyl selected from the group consisting of 5 morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2- azabicyclo[2.2.1]heptanyl and thiamorpholinyl, where the /V-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; 10 R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloaikyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7 and -R8-S(O),RQ (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, 15 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloaikyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 20 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; and 25 each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1 k) which is 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-cyano-4-(3,9-diazabicyclo[3.3.2]decan-10-on-3-yl)phenyl)pyrimidin-2-amine. 30 Another embodiment is a compound of formula (la-1 k), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; 35 R3, when present, is independently selected from the group consisting of alkyl, halo and 101 102 10 15 20 25 30 haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl,2,3,4,5-tetrahydro-1H-benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazinyl, 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5H-pyrido[2,3-e)pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, and 3,4-dihydro-2W-pyrido[3,2-bj[1,4joxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R8)R7, -R8-C(N=R6)N(R8)R7 and -R8-S(O)tR0 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyi, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroaryialkenyl, and optionally substituted heteroaryialkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-1k) which is 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-cyano-4-(3,9-diazabicyclo[3.3.2]decan-10-on-3-yl)phenyl)pyrimidin-2-amine.

Another embodiment of the compounds of formula (la-1), as set forth above, is a compound according to formula (la-11): 102 103

<img img-format="tif" img-content="drawing" file="IL207609AD000225.tif" id="idf0025" />

wherein n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, benzo[6]azepinyl, 2,3,4,5-tetrahydro-1 H-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3’,4’-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2/-/-pyrido[3,2-b][ 1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5/-/-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5H-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N- 8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, 8 /·&gt;i-)8 ^/r\\MZD6a\c37a r&gt;8 M/c&gt;6a\n7a πθ M/r&gt;6a\ ηθ M/r&gt;63\D7a -R -C(O)OR ,-R -C(O)N(R )R ,-R -N(R a)R , -R0-N(Rba)-R9-N(R6a)R? -R8-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where the /V-heterocyclyl, the /V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R8, -R8-N(R6)R7, -Rs-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyi, haloalkyl, haloalkenyl, haloaikynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally 103 104 substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R5, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O),R6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heteroaryl or an optionally substituted N-heterocyclyl; each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-11), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of alkyl, haloalkyl, cyano, -R8-OR6a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a and -R8-N(R6a)-R9-OR7a; RSa is independently selected from the group consisting of hydrogen, alkyl, -R9-N(R6)R7 and optionally substituted heterocyclyl; each R6 and each R7 is independently selected from the group consisting of hydrogen, 104 105 alkyl, alkenyl, alkynyl, haloalkyl, haloaikenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any Rs and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl, and when any R6a and R7a are bonded to a common nitrogen, R6a and R7a together with the common nitrogen to which they are both attached, may form an optionally substituted N-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-11) selected from the group consisting of: 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-(3-(dimethy!amino)-8-azabicyclo[3.2.1joctan-8-yl)phenyl)pyrimidin-2-amine; and 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-y!)-A/-(3-methyl-4-(3-(morpho!in-4-yl)-8- azabicyclo[3.2.1]octan-8-yl)phenyl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-11), as set forth above, wherein: n is 0 or 1; R2a is independently selected from the group consisting of hydrogen, optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an N-heterocyclyl selected from the group consisting of 105 106 morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1]heptanyi and thiamorpholinyl, where the A/-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally 5 substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, -R9-N(R6)R7 and optionally substituted heterocyclyl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 10 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted 15 heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R8 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heteroaryl or an optionally substituted N-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an 20 optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-11) selected from the group consisting of: 4-(6-(morpholin-4-yl)pyndin-3-yl)-/V-(3-methy!-4-(3-(morpholin-4-y!)-8- 25 azabicyclo[3.2.1]octan-8-yl)phenyl)pyrimidin-2-amine; and 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(3-(dimethylamino)-8- azabicyclo[3.2,1 ]octan-8-yl)phenyl)pyrimidin-2-amine.

Of the compounds of formula (la-1), as set forth above, another embodiment is a compound wherein: 30 n is 0 or 1; m is 0 or 1; R1 is selected from the group consisting of hydrogen or alkyl; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR8; 35 R3, when present, is independently selected from the group consisting of alkyl, halo and 106 107 haloalkyl; R4 is heteroaryl optionally substituted by a bridged /V-heterocyclyl, where the bridged N~ heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo and optionally substituted aryl; 5 Rs is a non-bridged /V-heterocyclyl, wherein a nitrogen atom in the non-bridged ZV-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, optionally substituted aryi, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally 10 substituted heteroaryl, optionally substituted heteroarylalkyl, -R8-C(O)R6, -Re-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R8)R7, -R8-S(O)2N(R6)R7, and -R8-S(O),R6 (where t is 1 or 2); and wherein a carbon atom in the non-bridged /V-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, halo, haloalkyl, optionally substituted aryi, optionally substituted aralkyl, 15 optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)PR6 (where p is 0, 1 or 2); 20 each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloaikyi, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl; or any R6 and R7 25 together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. 30 Of this embodiment, one embodiment is a compound of formula (la-1) wherein: n is 0 or 1; m is 1; R1 is selected from the group consisting of hydrogen or alkyl; R2 is alkyl; 35 R\ when present, is independently selected from the group consisting of alkyl, halo and 107 108 haloalkyl; R4 is pyridinyl substituted by a bridged A/-heterocyclyl, where the bridged N-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo and optionally substituted aryl; and R5 is a non-bridged A/-heterocyclyl selected from the group consisting of piperazinyI, piperidinyl and morpholinyl. A specific embodiment of this embodiment is a compound of formula (la-1) selected from the group consisting of: 4-(6-((1 S,4$)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)-/V-(3-methyl-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine; and 4-(6-((1 S,4S)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yi)-/V-(3-methyl-4-(4-methylpiperazin-1-yi)phenyl)pyrimidin-2-amine.

Another embodiment of the invention is a compound of formula (la), as set forth above in the Summary of the Invention, according to formula (la-2): R' (la-2) wherein: n is 0, 1 or 2; m is 0, 1 or 2; R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, -R8-C(O)OR6, -R9-N(R8)R7 and -R9-OR6; each R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; each R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of aryl and heteroaryl, where the aryl and the heteroaryl are each independently optionally substituted by one or more 108 109 substituents selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, /V-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR6a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R8a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted aralkyl, and where the /V-heterocyclyl, the A/-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5 is an /V-heterocyclyl, wherein a nitrogen atom in the /V-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -Re-OR6, -Re-C(O)R8, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=R8)N(R6)R7, -R8-S(O)jN(R8)R7, and -Re-S(O),R6 (where t is 1 or 2); and a carbon atom in the /V-heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, haloalkynyl, oxo, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(RQ)R7, 109 110 -R8-C(O)N(R6)R7, -Rb-S(O)2N(R6)R7, and -R8-S(O)PR6 (where p is 0, 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycioalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, 5 optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted 10 heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted V-heteroaryl or an optionally substituted V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally 15 substituted straight or branched aikenylene chain and an optionally substituted straight or branched alkynylene chain; and each R9 is independently selected from the group consisting of an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched aikenylene chain and an optionally substituted straight or branched alkynylene 20 chain; provided at least one of R5 and a substituent on R4 is a bridged V-heterocyclyl;

Of the compounds of formula (la-2), as set forth above, one embodiment is a compound selected from the following: 110 111

<img img-format="tif" img-content="drawing" file="IL207609AD000226.tif" id="idf0026" />

wherein: each n is 0, 1 or 2; each m is 0, 1 or 2; 5 each R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; each R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; 111 112 each R4 is independently selected from the group consisting of aryl and heteroaryl, where the aryl and the heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, /V-heteroaryl, aryl, -R8-OR6a, -R8-S(O)pRQa (where p is 0, 1 or 2), -R8-C(O)R8a, -R8-C(O)OR8a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a, -R8-N(R6a)-R9-OR7a, -R8-N(R8a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and -R8-N(R6a)-R9-N(R6a)S(O)2R7a, where each R8a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted aralkyl, and where the /V-heterocyclyl, the /V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; each R5a is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycioalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -R8-C(O)R8, -R8-C(O)OR6, -R9-N(R8)R7, -R8-C(O)N(R6)R7, -Rb-C{N=R6)N(R8)R7, -R8-S(O)2N(R6)R7, and -R8-S(O),R8 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycioalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted 112 113 heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; each R8 is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; and each R9 is independently selected from the group consisting of an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain.

Of this embodiment, one embodiment is a compound selected from the formulae above wherein: each n is 0 or 1; each m is 0 or 1; each R4 is independently selected from the group consisting of phenyl, benzimidazolyl, benzo[b][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1/7-benzo[b]azepinyl, 3,4-dihydro-2H-benzo[b][1,4]thiazinyl, 3’,4'-dihydrospiro[cyclobutane-1,2’-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazinyl, imidazo[1,2-a]pyridiny1, 6,7,8,9-tetrahydro-5/7-pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5W-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N-heteroaryl, aryl, -R8-OR8a, -Rs-S(O)pRea (where p is 0,1 or 2), -R8-C(O)R6a, -Ra-C(O)OR6a,-R8-C(O)N(R6a)R7a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R8a)R7a, -R8-N(R8a)-R9-OR7a, -R8-N(R6a)C(O)R7a, -R8-N(R8a)S(O)2R7a, -R8-N(R6a)C(O)-Re-N(R8a)R7a, and -R8-N(R8a)-R9-N(R6a)S(O)2R7a, where the /V-heterocyclyl, the /V-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R8, -R8-N(R6)R7, -R8-C(O)N(Rs)R7, alkyl, halo and optionally substituted aryl; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted 113 114 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted 5 heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; 10 each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; each R8 is independently selected from the group consisting of a direct bond and an 15 optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

One embodiment of the compounds of formula (la-2), as set forth above, is a compound according to formula (la-2a);

<img img-format="tif" img-content="drawing" file="IL207609AD000227.tif" id="idf0027" />

20 n is 0 or 1; m is 0 or 1; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR8; R3, when present, is independently selected from the group consisting of alkyl, halo and 25 haloalkyl; R4 is selected from the group consisting of phenyl, benzimidazolyl, benzot&amp;amp;][1,4]oxazinyl, benzo[b]azepinyl, 2,3,4,5-tetrahydro-1 /-/-benzo[b]azepinyl, 3,4-dihydro-2/-/-benzo[t»][ 1,4]thiazinyl, 3',4'-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, 3,4-dihydro-2H- 30 pyrido[3,2-b](1,4]thiazinyl, imidazo[1,2-a]pyridinyl, 6,7,8,9-tetrahydro-5W- 114 115 pyrido[2,3-b]indolyl, 7,8,9,9a-tetrahydro-5B-pyrido[2,3-e]pyrrolo[1,2-aj[1,4]diazepin-10(11W)-onyl, indolyl, indolinyl, naphthyridinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1 H-pyrrolo[2,3-b]pyridinyl, and thiazolyl, each optionally substituted by one or more substituents independently selected from the group consisting of oxo, alkyl, halo, haloalkyl, cyano, /V-heterocyclyl, N-heteroaryl, aryl, -R8-OR8a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-C(O)R6a, -R8-C(O)OR8a,-R8-C(O)N(R8a)R7a, -R8-N(R6a)R7a,-R8-N(R6a)-R9-N(R8a)R7a, -R8-N(R6a)-R9-OR7a, -R’-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a -R8-N(R6a)C(O)-R8-N(R8a)R7a, and -R8-N(R8a)-R9-N(R6a)S(O)2R7a, where the /V-heterocyclyl, the A/-heteroaryl and the aryl are each independently optionally substituted by one or more substituents selected from the group consisting of -C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; RSa is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, -R8-OR6, -RS-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R6)R7, -R8-C(N=Rs)N(R6)R7, -R8-S(O)2N(R6)R7, and -R8-S(O)tR6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; 115 116 each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycioalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; each R® is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain.

Of this embodiment, one embodiment is a compound of formula (la-2a) wherein: n is 0 or 1; m is 0 or 1; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of alkyl, cyano, -R8-OR6a, -R8-N(R6a)R7a, -R8-N(R6a)-R9-N(R6a)R7a and -R8-N(R6a)-R9-OR7a; R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 and -R8-S(O)tR6 (where t is 1 or 2); and each R6 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycioalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; R6a and R7a are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycioalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. 116 117 A specific embodiment of this embodiment is a compound of formula (la-2a) selected from the group consisting of: 4-(6-(dimethylamino)pyndin-3-yl)-N-(6-((1Sl4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin~3-yl)pyrimidin-2-amine; and 4-(6-aminopyridin-3-yl)-A/-(5-methyl-6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yi)pyridin-3-yl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-2a) wherein: n is 0 or 1; m is 0 or 1; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by an /V-heterocyclyl selected from the group consisting of morpholinyl, piperazinyl, piperidinyl, oxazepanyl, 5-oxa-2-azabicyclo[2.2.1]heptanyl and thiamorpholinyl, where the /V-heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; RSa is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -R8-C(O)N(R8)R7, -R8-C(N=R6)N(R6)R7 and -R8~S(O)tR6 (where t is 1 or 2); each R8 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloaikenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an 117 118 optionally substituted /V-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-2a) selected from the group consisting of: 4-(6-(4-acetylpiperazin-1-yl)pyridin-3-yl)-N-(6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-/V-(6-((1S,4S)-5-methyl-2,5- diazabicycio[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(4-acetylpiperazin-1-yl)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-((1 S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)- 5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine. Another embodiment is a compound of formula (la-2a) wherein: n is 0 or 1; m is 0 or 1; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is pyridinyl substituted by one or more substituents selected from the group consisting of -R8-C(O)R6a, -R8-C(O)N(R6a)R7a, -R8-S(O)pR6a (where p is 0, 1 or 2), -R8-N(R6a)-R9-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, and tetrazolyl; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, -R8-C(O)R6, -Rs-C(O)N(R6)R7, -R8-C(N=R6)N(R6)R7 and -R8-S(O),R6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, 118 119 optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted A/-heteroaryl or an optionally substituted /V-heterocyclyl; each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain; and each R9 is an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-2a) selected from the group consisting of; 4-(6-(methylcarbonylamino)pyridin-3-yl)-/V-(6-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyi-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(acetamido)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; and 4-(6-(methylsulfonylamino)pyridin-3-yl)-/V-(5-methyl-6-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine.

Another embodiment is a compound of formula (la-2a) wherein; n is 0 or 1; m is 0 or 1; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of naphthyridinyl, benzo[b]azepinyl, benzo[b][1,4]oxazinyl, 3,4-dihydro-2H-benzoib][1,4]thiaziny1, 3',4'-dihydrospiro[cyc!obutane-1,2'-pyrido[3f2-£&gt;][ 1,4]oxazinyl, 3,4-dihydro-2H- 119 120 pyrido[3,2-b][1,4]thiazinyl and 3,4-dihydro-2/7-pyrido[3,2-P][1,4]oxazinyl, each optionally substituted by one or more substituents independently selected from the group consisting of alkyl and oxo; R5a is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloaikyi, optionally substituted cycloalkylalkyl, -R®-C(O)Re, -R8-C(O)N(Re)R7, -R8-C(N=R8)N(R8)R7, -R8-S(O),R6 (where t is 1 or 2), and -R8-S(O)2N(R8)R7; each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloaikyi, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclyialkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted /V-heteroaryl or an optionally substituted /V-heterocyclyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-2a) selected from the group consisting of: 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(5-methyl-6-((1$,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; and 4-(2,2-dimetbyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicycloi2.2.1]heptan-2-yl)pyridin-3-yl)pynmidin-2-amine.

Another embodiment is a compound of formula (la-2a) wherein: n is 0 or 1; m is 0 or 1; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is phenyl substituted by one or more substituents selected from the group consisting 120 121 of alkyl, -R8-OR6a, -R8-N(R6a)R7a, -R8-C(O)N(R6a)R7a, -R8-N(R6a)C(O)R7a, -R8-N(R6a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, N-heteroaryl and N-heterocyclyl, where the A/-heterocyclyl and the N-heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 and -R8-$(O)tR6 (where t is 1 or 2); each R6 and each R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N- hetero ary I or an optionally substituted /V-heterocyclyl; each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; and each R8 is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-2a) selected from the group consisting of: 4-(4-(dimethylamino)phenyl)-/V-(6-((1 S,4S)-5-m ethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(4-(dimethylamino)phenyl)-/V-(5-methyl-6-((1S,4S)-(5-methyl-2,5- diazabicyc!o[2.2.1]heptan-2-yl)pyrtdin-3-yl)pyrimidin-2-amine; 4-(4-(f-butylcarbonylamino)phenyl)-/V-(5-methyt-6-((1S,4S)-5-methyl-2l5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; and 4-(4-(3-cyclopropylureido)phenyl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.13heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine. 121 122

Another embodiment is a compound of formula (la-2a) wherein: n is 0 or 1; m is 0 or 1; R2, when present, is independently selected from the group consisting of optionally substituted alkyl, halo, cyano and -OR6; R3, when present, is independently selected from the group consisting of alkyl, halo and haloalkyl; R4 is selected from the group consisting of benzimidazolyl, imidazo[1,2-a]pyridinyl, indoiyl, indolinyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, 1H- 10 15 pyrrolo[2,3-b]pyridinyl and thiazolyl, each independently substituted by one or more substituents selected from the group consisting of alkyl, cyano, oxo,

<img img-format="tif" img-content="drawing" file="IL207609AD000228.tif" id="idf0028" />

-R8-N(R8a)S(O)2R7a, -R8-N(R6a)C(O)-R8-N(R6a)R7a, aryl, ΛΖ-heteroaryl and N-heterocyclyl, where the aryl, the /V-heterocyclyl and the A/-heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of-C(O)R6, -R8-N(R6)R7, -R8-C(O)N(R6)R7, alkyl, halo and optionally substituted aryl; R5a is independently selected from the group consisting of hydrogen, alkyl, -R8-C(O)R6 and -R8-S(O)tR6 (where t is 1 or 2); 20 each R6 and each R7 is independently selected from the group consisting of hydrogen, 25 30 alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted W-heteroaryl or an optionally substituted /V-heterocyclyl; each R6a and R7a is independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, and optionally substituted aralkyl; and 35 each R8 is independently selected from the group consisting of a direct bond and an 122 123 optionally substituted straight or branched alkylene chain. A specific embodiment of this embodiment is a compound of formula (la-2a) selected from the group consisting of: 4-(2-(dimethylamino)thiazol-4-yl)-/\/-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan- 5 2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(5-(morpholin-4-yl)pyrazin-2-y!)-/V-(6-((1$,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)pyridin-3-yl)pyrimidin-2-amine; and 4-(1-(pyridin-4-yl)-1W-indol-5-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyc!o[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine. 10 In certain embodiments of the compounds of the invention, n is 0 or 1.

In certain embodiments of the compounds of the invention, m is 0 or 1.

In certain embodiments of the compounds of the invention, Y is =C(R6)-.

In certain embodiments of the compounds of the invention Y is =N-.

In certain embodiments of the compounds of the invention, R1 is selected from 15 the group consisting of hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, -R8-C(O)OR6, -R9-N(R6)R7 and -R9-OR6;

In certain embodiments of the compounds of the invention, R5 is an N-heterocyclyl, wherein a nitrogen atom in the N-heterocyclyl is optionally substituted by a 20 substituent selected from the group consisting of alkyl, haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, -Re-OR6, -R8-C(O)R6, -Re-C(O)OR6, -R9-N(R8)R7, -R8-C(O)N(R6)R7, -R8-C(N=R8)N(R8)R7, 25 -R8-S(O)2N(R8)R7, and -R8-S(O)IR8 (where t is 1 or 2); and a carbon atom in the N- heterocyclyl is optionally substituted by a substituent selected from the group consisting of alkyl, halo, haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted 30 heteroaryl, optionally substituted heteroarylalkyl, -R8-OR6, -R8-C(O)R6, -R8-C(O)OR6, -R9-N(R6)R7, -R8-C(O)N(R8)R7, -R8-S(O)2N(R8)R7, and -R8-S(O)PR8 (where p is 0, 1 or 2).

In certain embodiments of the compounds of the invention, each R8 and each R7 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, 35 optionally substituted aryl, optionally substituted aralkyl, optionally substituted 123 124 heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl.

In one embodiment, the compounds of formula (I) are selected from the group consisting of: 4-(6-(V,A/-dimethylamino)pyridin-3-yl)-V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(WlN-dimethylamino)pyridin-3-yl)-5-methyl-/\/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(V,V-dimethylamino)pyridin-3-yl)-5-trifluoromethyl-V-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(V,V-dimethylamino)pyridin-3-yl)-5-fluoro-V-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(A/,N-dimethylamino)pyridin-3-yl)-5-fluoro-A/-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-( A/,A/-cNmethylamino)pyridin-3-yl)-5-methyl-A/-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(V,V-dimethylamino)pyridin-3-yl)-V-(3-fluoro-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-V-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-V-(3-ftuoro-4-(5-methyl-2,5- diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-V-(3-methyl-4-(5-rnethyl-2,5-diazabicyclo[2.2.1jheptan- 2-yl)phenyl)pyrimidin-2-amine, 4-(6-(morpholin-4-yl)pyridin-3-yl)-V-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.13heptan-2 yl)phenyl)pyrimidin-2-amine; 4-(6-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yi)pyridin-3-yl)-V-(3-methyl-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine; 4-(6-(5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)-V-(3-methyl-4-(4· methyipiperazin-1-yl)phenyl)pyrimidin-2-amine; 4-(4-(V,V-dimethylamino)phenyl)-V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan« 2-yl)phenyl)pyrimidin-2-amine; 4-(4-(/V,V-dimethylamino)phenyl)-V-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine; 124 125 4-(6-(4-acetylpiperazin-1 -yl)pyridin-3-yl)-N-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pynmidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/-/-pyrido[3,2-b][ 1,4]oxazin-7-yl)-A/-(3-fluoro-4-(5-methyl-2!5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2B-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1 H-indol-6-yl)-A/-(3-methyl-4-(5-methy!-2,5-diazabtcyclo[2.2.1 ]heptan-2-yl)phenyi)pyrimidin-2-amine; 4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-N-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)pheny!)pyrimidin-2-amine; 4-(1H-pyrrolo[2,3-b]pyndin-5-yl)-N-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.13heptari-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-/\/-(3-methyl-4-(5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methy!-4-(5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(5-((ethylamino)carbonyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2H-pyrido[312-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-(5-oxa 2-azabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-(ethylcarbonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3'-oxo-3’,4’-dihydrospiro[cyclobutane-1,2'-pyrido[3l2-b][1l4]oxazine]-7,-yl)-/V-(3-methyl 4-(5-methyl-2I5-diazabicyclo[2.2J]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3,-oxo-3’)4,-dihydrospiro[cyclobutane-1,2,-pyrido[3,2-b][1,4]oxazine]-7,-yl)-A/-(3-methyl· 4-(5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1 H-pyrrolo[2,3-b]pyridin-5-yl)-A/-(3-methyl-4-(5-oxa-2-azabicyclo[2.2,1 ]heptan-2- yi)phenyl)pyrimidin-2-amine; 4-(1 H-pyrrolo[2,3-b]pyridin-5-yl)-A/-(3-methyl-4-(5-(2l212-trifluoroethyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 125 126 4-(1 H-pyrrolo[2,3-b]pyridin-5-yl)-A/-(3-methyl-4-(5-(cyclopropyl)methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(5-(2,2,2-trifluoroethyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 5 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(5-(cyclopropyl)methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-314-dihydro-2/-/-pyrido[3,2-P][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-(aminosulfonyl)-2,5-diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3-fluoro-2-(morpholin-4-yl)pyridin-4-yl)-/V-(3-fluoro-4-(5-methyl-2,5-10 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-N-(4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-/V-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-y!)phenyl)pyrimidin-2-amine; 15 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-N-(3-methyl-4-(5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-A/-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-( (cyclopropyl)carbonylamino)-pyrimidin-5-y!)-A/-(3-methy]-4-(5-methyl-215-20 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amtne; 4-(4-(4,5-dihydrothiazol-2-ylcarbamoyl)phenyl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(1,1-dimethylethyl)phenyl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2 yl)phenyl)pyrimidin-2-amtne; 25 4-(4-(morpholin-4-yl)phenyl)-N-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine.TFA salt; 4-(4-((methyi)aminocarbonylmethyl)-phenyl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pynmidin-2-amine.TFA salt; 4-(4-((cyclopropyl)aminocarbonyl-methyl)phenyl)-N-(3-methyl-4-(5-methyl-2,5-30 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(methylaminocarbonyl)pyridin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(7-oxo-5l6,7l8-tetrahydro-1,8-naphthyridin-3-yl)-A/-(3-methyl-4-(5-methyl-2l5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.TFA salt; 126 127 4-(5-((rnorpholin-4-yl)carbonyl)pyridin-3-yl)-A/-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine.Bis TFA salt; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/-/-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-cyano-4-(5-methyl-2,5-diazabicyclo[2.2.13heptan-2-yl)phenyl)pyrimidin-2-amine; 5 4-(5-methyt-6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-(5-methyl-2,5-diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4- (5-methyl-6-(morpholin-4-yl)pyndin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 5- methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(5-methyl-2,5- 10 diazabtcyclo[2.2.1 j hepta n-2-y I) pheny l)py ri m id in-2-amine; 5-methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 15 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-N-(3-fluorO’4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-20 2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2 yl)phenyl)pyrimidin-2-amine; 25 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1jnonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(cyclohexylamino)pyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3l7-30 diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(cyclohexylamino)pyridin-3-y!)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(cyclohexylamino)pyridin-3-yl)-/V-(3-fluoro-4-(5-methyl-2,5- diazabicyclo[2.2.1jheptan-2-yl)phenyl)pyrimidin-2-amine; 127 128 4-(6-(benzyl)pyridin-3-yl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(benzyl)pyridin-3-yl)-N-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-fluoro-4-(1l5,7-trimethyi-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-/V-(3-fluoro-4-(1,5,7-trimethyl-3l7-diazabicycloi3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(4-(dimethylamino)phenyf)-/V-(3-fluoro-4-(1 .SJ-trimethyl-SJ-diazabicyclop.S. 1 ]nonan- 3-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-(1,5I7-trimethyl-317-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(3l4-dihydro-2W-pyndo[3,2-b][1l4]oxazin-7-yl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3l4-dihydro-2H-pyrido[3t2-b7[1l4]oxazin-7-yl)-N-(3-fluoro-4-(5-methyl-2t5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3,4-dihydro-2H-pyndo[3,2-b][1,43oxazin-7-yl)-A/-(3-methyl-4-(1,5,7“tnmethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(3l4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(benzyl)pyrίdίn-3-yl)-Λ/-(3-methyl·4-(1,5l7-trimethyl·3l7-diazabicyclo[3.3.1]nonan-3- yl)pheny!)pyrimidin-2-amine; 4-(6-(benzyl)pyridin-3-yl)-A/-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyc!o[3.3.1]nonan-3- yl)phenyl)pyrimidin-2-amine; 4-(2-(propyl)aminopyrimidin-5-yl)-Λ/-(3-methyl·4-(5-methyl-2)5’dίazabicycloί2.2.1]heptan 2-yl)phenyl)pyrimtdin-2-amine; 4-(2-(propyl)aminopyrimidin-5-yl)-A/-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine; 4-(6-(cyclohexylamino)pyridin-3-yl)-N-(3-triftuoromethyl-4-(5-m'ethyl-2,5- diazabicyclo[2.2.1Jheptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-(methyl)sulfonyipyridin-3-y!)-U-(3-methyl-4-(5-methyl-2,5-diazabicyc!o[2,2.1]heptan· 2-yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3-trifluoromethyl-4-(5“methyl-215-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 128 129 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-trifluoromethyl-4-(5-methyl-2,5-diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3l4-dihydro-2H-pyrido[3l2-b][1l4]oxazin-7-yl)-/V-(3-trifluoromethyl-4-(5-methyl-2l5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-((2-(cyclopropylsulfonyl)aminoethyl)-amino)pyridin-3-yl)-N-(3-methyl-4-(5-methyl- 2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-((2-(cyclopropylsulfonyl)aminoethyl)-aniino)pyridin-3-yl)-A/-(3-methyl-4-(5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-(methyl)suifonylpyridin-3-yl)-A/-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(5-(methyl)sulfonylpyridin-3-yl)-/V-(3-trifiuoromethyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(imtdazo[1,2-a]pyridin-6-yi)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyi)pyrimidtn-2-amine; 4-(4-(5-(4-dimethylaminophenyl)oxazol-2-yl)phenyi)-A/-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine; 4-(6-methoxy-1H-indol-2-yl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(1-(3-chlorophenyl)-1H-pyrazoi-4-yl)-A/-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1 -methylbenzimidazol-6-yl)-N-(3-rnethyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(5-cyano-1H-indol-2-yl)-A/-(3-methy!-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(1-(4-fluorophenyi)-1/7-pyrazol-4-yl)-A/-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(7-azabicyclo[2.2.1]heptan-7- yl)phenyl)pyrimidin-2-amine; 4-(6-cyanopyridin-3-yi)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-cyanopyridin-3-yl)-A/-(3-rnethyl-4-(7-azabicyclo[2.2.1]heptan-7-yi)pheny()pyrimidin-2- amine; 4-(2-oxoindolin-5-yl)-A/-(3-methyl-4(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 129 130 4-(5-cyanopyridin-3-yl)-W-(3-methyl-4(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(1 H-tetrazol-5-yl)pyridin-3-yl)-W-(3-methyl-4(5-methyl-2,5-diazabicyclo[2.2.1]heptan· 2-yl)phenyl)pyrimidin-2-amine; 5 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-cyano-4-(5-acetyl-2,5-diazabicyclo[2.2.1 ]heptan-2 yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yi)-W-(3-cyano-4-(5-methylsulfonyl-2,5- diazabicycloi2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-W-(3-cyano-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-10 2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-cyano-4-(5-cyclopentyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4- yl)phenyl)pyrimidin-2-amine; 15 4-(2-oxoindolin-5-yl)-W-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4-yl)phenyl)pyrimidin-2 amine; (1-methylbenzimidazol-6-yl)-W-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4- yl)phenyl)pyrimidin-2-amine; 4-(imidazo[1,2-a]pyridin-6-yl)-W-(3-methyl-4-(1,4-diazabicyclo[3.2.1 ]octan-4-20 yl)phenyl)pyrimidin-2-amine; 4-(2H-benzo[b][1,4]oxazin-3(4H)-on-6-yl)-W-(3-fluoro-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2,4-trimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-W-(3-methyl-4-(5-methyi-2,5-diazabicyclo[2,2.1]heptan-2-yl)phenyl)pynmidin-2-amine; 25 4-(2,2,4-trimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-W-(3-fluoro-4-(5- methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine; 4-(5-(3-methylpiperidin-1-yl)pyrazin-2-yl)-W-(3-fluoro-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(i-butylcarbonylamino)phenyl)-W-(3-fluoro-4-(5-methyl-2,5-30 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(i-butylcarbonyiamino)phenyl)-/\/-(3-methyl-4-(5-methyl-215-diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-methyi-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 130 131 4-(6-(acetamido)pyridin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(4-((pyridin-2-yl)aminocarbonyt)phenyl)-/V-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 5 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyc)o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(methylsulfonylamino)phenyl)-A/-(3-fluoro-4-(5-methyl-2,5’diazabicyclo[2.2.13heptan 2-yl)phenyl)pyrimidin-2-amine; 4-(4-(methylsulfonylamino)phenyl)-A/-(3-methyl-4-(5-methyl-2,5-10 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3l2-b][1,4]oxazin-7-yl)-A/-(4-(5-methyl-2,5- diazabicyc!o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(3-cyclopropylureido)phenyi)-A/-(4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 15 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-A/-(3-methyl-4-(5-methyl-215-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-A/-(4-(5-methyi-2,5- diazabicyc(o[2.2.1]heptan-2-yl)phenyl)pyrimtdin-2-amine; 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-/V-(3-fluoro-4-(5-methyl-2,5-20 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(acetamido)pyridin-3-yl)-N-(3-methyl-4-(5-oxa-2-azabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-aminopyridin-3-yl)-N-(3-methyl-4-(5-ethylcarbonyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 25 4-(6-(acetamido)pyridin-3-yl)-N-(3-methyl-4-(5-ethylcarbonyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6’aminopyridin-3-yl)-/V-(3-methyl-4-(5“methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(methylsulfonylamino)pyridin-3-yl)-N-(3-methyl-4-(5-methyl-2,5-30 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(dimethylamino)acetamido)-pyridin-3-yl)-N-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-y!)phenyl)pyrimidin-2-amine; 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(3-fluoro-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 131 132 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(4-(8-methyl-3,8-diazabicyclo[3.2.1 ]octan-3- yl)phenyl)pyrimidin-2-amine; 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(4-(8-methy!-3,8-diazabicyclo[3.2.1]octan-3~ yl)phenyl)pyrimidin-2-amine; 5 4-(2,2-dimethyl-3-oxo-3,4-dthydro-2H-pyrido[3,2-5)(1,4]oxazin-7-yl)-/V-(4-(8-methyl-3,8- diazabicyclo[3.2.1]octan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-aminopyridin-3-yl)-/V-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3- yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3,2.2]nonan-4-10 yl)phenyl)pyrimtdin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-5][1,4]oxazin-7-yl)-A/-(3-methyl-4-(1l4- diazabicyclo(3.2.2]nonan-4-yl)phenyi)pyrimidin-2-amine; 4-(4-((pyridin-2-yf)arninocarbonyl)phenyl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.2]nonan-4- yl)phenyl)pyrimidin-2-amine; 15 4-(4-(acetamido)phenyl)-A/-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)pyrimidin-2-amine; 4-(2-(diethylamino)thiazol-4-yl)-/\/-(3-methyi-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(2-(diethylamino)thiazol-4-yl)-/V-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-20 yl)phenyl)pyrimtdin-2-amine; 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2W-pyrido[312-b][1,4]oxazin-7-yl)-N-(3-methyl-4-(8-methyl-S.e-diazabicyclop^.lloctan-S-ylJphenyOpyrimidin^-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3· yl)phenyl)pyrimidin-2-amine; 25 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1 )octan-3-yl)phenyl)pyrimidin-2-amine; 4-(4-(Fbutylcarbonylamino)phenyl)-N-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1Joctan 3-yl)phenyl)pyrimidin-2-amine; 4-(1 /7-pyrrol-3-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-30 yl)phenyl)pyrimidin-2-amine; 4-(1H-pyrrol-3-yl)-A/-(4-(5-methyl-2,5-diazabicyclo[2.2.1)heptan-2-yl)phenyl)pyrimidin-2- amine; 4-(1 H-pyrrol-3-yl)-/V-( 3-trifluoromethyl-4-(5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 132 133 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2/-/-pyrido[3,2-t&gt;][1,4]oxazin-7-yi)-A/-(3-trifluoromethyl-4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pheny))pyrimidin-2-amine; 4-(6-ethoxypyridin-3-yl)-A/-(3-methyt-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-ethoxypyridin-3-yl)-A/-(3-fluoro-4-(5-methyl-2,5-diazabicycio[2.2.13heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(2-(dimethylamino)thiazoi-4-yl)-/V-(3-methyl-4-(5-methyl-2l5-diazabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine; 4-(2-(dimethylamino)thiazol-4-yl)-A/-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine, 4-(5-(morpholin-4-yl)pyrazin-2-yl)-/V-(3-methyl-4-(5-methyl-2,5'diazabicyc!o[2.2.1]heptarl· 2-yl)phenyl)pyrimidin-2-amine; 4-(5-(morpholin-4-yl)pyrazin-2-yl)-/V-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine; 4-(4-(1-ethoxyethyl)phenyl)-N-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(1-ethoxyethyl)phenyl)-N-(3-fluoro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-A/-(4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3~yl)-N-(4-(5-methyl-2,5-diazabicycloI2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-6][1,4joxazin-7-yl)-N-(4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5- diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(c/'s-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(5-methyi-215- diazabicyclo[2.2.1]heptan-2-yl)pheny()pyrimidin-2-amine; 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pheny!)pyrimidin-2-amine; 4-(6-(2-(dimethylamino)methylmorpholin-4-yl)pyridin-3-yl)-A/-(3-rnethyl-4-(5-rnethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(piperidin-1-yl)pyridin-3-yl)-/V-(3-methyl-4-(5’methyl-2,5-diazabicyclo[2.2.1]heptan-2 yl)phenyl)pyrimidin-2-amine; 133 134 4-(6-(3-(aminocarbonyl)piperidin-1-yl)pyridin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(5-methylsulfonyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-methyl-3l4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-methy!-4-(5- methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(5-oxa-2-azabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-arnine; 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/\/-(3-methyt-4-(5-oxa-2-azabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(5-ethylcarbonyl-2,5- diazabicyclo(2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(3-methyl-4-(5-ethylcarbonyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-dimethylamino)propylaminopyridin-3-yl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpho(in-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(5-amidino-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine. TFA salt; 4-(6-(3-ethoxypropyl)aminopyridin-3-yi)-A/-(3-methyl-4-(5-oxa-2-azabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine; 4-(6-c/s-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-(5-oxa-2-azabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(6-(3-dimethylamino)propylaminopyridin-3-yl)-A/-(3-methyl-4-(5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(1,4-oxazepan-4-yl)pyridin-3-yl)-N-(3-methyl-4-(5-oxa-2-azabicyclo[2.2.1]heptart-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/\/-(3-methyl-4-(5-isobutyl-2,5-diazabicyclo[2.2.1]heptan 2-yl)phenyl)pyrimidin-2-amine; 4-(6-(1,4-oxazepan-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 134 135 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2K-pyrido[3,2-t&gt;][1,4joxazin-7-yl)-/V-(3-fluoro-4-(1,5,7-tnmethyl-3,7-diazabicyclo[3.3.13nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3,4-dihydro-2H-pyrido[3l2-b][1,4]oxazin-7-yl)-/\/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 5 4-(3-oxo-3,4-dihydro-2H-pyrtdo[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-(5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-A/-(3-methyl-4-(1,5,7-tnmethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-((2S,6R)-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(1,5,7-tnmethyl-3,7 10 diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-(1l5l7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-dimethylamino)propylaminopyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine; 15 4-(6-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyridin-3-yl)-A/-(3-rnethyi-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)-/V-(3-methyl-4-(5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3-methytbutyl)aminopyridin-3-yl)-A/-(3-methyi-4-(5-rnethyl-2,5-20 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(3,3-dimethylbutyl)aminopyridin-3-y!)-/V-(3-rriethyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-y()phenyl)pyrimidin-2-amine; 4-(6-(2-methoxyethyl)(methyl)aminopyridin-3-y^)-^/-(3-methyl-4-(5-methy^-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 25 4-(6-(2-methoxyethyl)(methyl)aminopyridin-3-yl)-/V-(3-methyl-4-(5-oxa-2-azabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-methoxyethyl)(methyl)aminopyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.13nonan-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(2-azabicyclo[2.2.1]heptan-2-30 yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b}[ 1,4]oxazin-7-yt)-A/-(3-methyl-4-(2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/-/-pyrido[3,2-b}[1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine and 4- 35 (2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3l2-6][1,4loxazin-7-yl)-/\/-(3-methyl-4- 135 136 (2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yl)phenyl)pyrimidin-2-amine (68:31); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-rnethyl-4-(2-methylsulfonyl-2- azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine and 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yl)phenyl)pyrimidin-2-amine (85:15); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-d][1,4]oxazin-7-yl)-A/-(4-(2- methylsulfonyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-5- yt)phenyl)pyrimidin-2-amine; 4-(2,2-dlmethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(4-(2- methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6- yl)phenyl)pyrimidin-2-amine; 4-(6-(thiamorpholin-4-y()pyridin-3-yl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyndin-3-yl)-/V-(3-rnethyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan· 2-yl)phenyl)pyrimidin-2-amine; 4-(1 -(pyridin-4-yl)-1H-indol-5-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(1-(pyridin-4-yl)-1H-indol-5-yl)-A/-(3-fluoro-4-(5-methyl-2l5-diazabicyclo[2.2.1]heptan-2 yl)phenyl)pyrimidin-2-amine; 4-(1-(pyridin-4-yl)-1/7-indol-5-yl)-A/-(3-methyl-4-(5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine; 4-(1-(pyridin-4-yl)-1H-indol-5-yl)-A/-(3-methyl-4-(5-isobutyl-2,5-diazabicyclo[2.2.1]heptan 2-yl)phenyl)pyrimidin-2-amine; 4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)-N-(3-methyl-4-(5-methylsulfonyl-2,5- diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine; 4-(6-(propylamino)pyridin-3-yt)-/V-(3-methyl-4-(5-methylsulfonyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3,4-dihydro-2/7-benzo[d][1l4]thiazin-7-yl)-A/-(4-(5-methyl-2l5- diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethy(-3-oxo-3,4-dihydro-2H-benzo[d][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-methyl 2,5-diazabicyclo[2.2.1]heptan-2-yl)pheny))pyrimidin-2-amine; 136 137 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-benzo[b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyi)pynmidin-2-amine; 4-(2-oxo-2,3,4,5-tetrahydro-1/7-benzo[/)]azepin-7-yl)-/\/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-oxo-2,3,4,5-tetrahydro-1/-/-benzo[d]azepin-7-yl)-/V-(3-methyl-4-(5-methylsulfonyl-2,5 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(619-methanooctahydro-1W-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(6,9-methanooctahydro-1H-pyrido[1,2- a]pyrazin-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyndo[3,2-b][1,4]oxazin-7-yl)-/\/-(3-inethy!-4-(5-(1-methylethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-bl[1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-cyclopropyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-t&gt;][1,4]oxazin-7-yl)-N-(3-chloro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-d][1,4]oxazin-7-yl)-A/-(3-chloro-4-(5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(5-cyclopentyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,43oxazin-7-yl)-/V-(3-methyi-4-(5-acetyl-2,5-diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-methyl-4-(1l4- diazabicycio[3.2.1]octan-4-yl)phenyl)pyrimidin-2-amine; 4-(5-(1 -methylethoxy)carbonylpropyl·6-aminopyridin-3-yl)-N-(3-methyl-4-(5-methyl-215-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidln-2-amine;; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(5-cyclopropyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridln-3-yl)-A/-(3-chloro-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)phenyl)pyrimidin-2-amine; 4-(2-(trifluoromethyl)pyridin-4-yl)-A/-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-chloro-4-(5-(rnethylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-y!)phenyl)pyrimidin-2-amine; 137 138 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-chloro-4-(5-(methylsulfonyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-chloro-4-(5-acetyl-2,5-diazabtcyclo[2.2.1]heptan-2' yl)phenyl)pyrimidin-2-amine; 4-(6-(tetrahydropyran-4-yfoxy)pyridin-3-yl)-A/-(3-chloro-4-(5-acetyl-2,5- diazabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-y!)-/V-(3~rnethyl-4-(5-methyl-2l5- diazabicyclo[2.2.1]heptan-2-y!)pheny!)pyrimidin-2-arnine; 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-(5-cyclopentyi-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-W-(3-chloro-4-(5-(1-methylethyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(2-oxa-5-azabicyclo[2.2.1jheptan-5-yl)pyridin-3-yl)-A/-(3-methyl-4-(5- (methy!suffonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6,7,8,9-tetrahydro-5H-pyrido[2,3-6]indol-3-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-3-yl)-A/-(3-methyl-4-(5-(methylsulfonyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(4-(trifluoromethyl)phenyl)-/\/-(3-methyl-4-(5-methyl-2l5-diazabicyclo[2.2.1jheptan-2- yl)phenyl)pyrimidin-2-amtne; 4-(7,8,9,9a-tetrahydro-5H-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11 H)-on-3-yl)-/V-(3-methyl-4-(5-methyl-2,5-diazabicycloi2.2.13heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[0][1,4]oxazin-7-yl)-A/-(3-cyano-4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-yl)-/V-(3-cyano-4-(5-methyl-2,5-dtazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3,4-dihydro-2W-benzo[b][1,4]thiazin-7-yl)-N-(3-cyano-4-(5-rnethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-/\/-(3-methyl-4-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine; 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4 yl)phenyl)pyrimtdin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(1,4-diazabicyclo[3.2.1 ]octan-4-yl)phenyl)pyrimidin-2-amine; 138 139 4-(2-oxo-2I3,4,5-tetrahydro-1H-benzo[b]azepin-7-yl)-/V-(3-methy!-4-(6,9- methanooctahydro-1H-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrimidin-2-amine; 4-(3-oxo-3,4’dihydro-2H-benzoi6][1,4]thiazin-7-yl)’/V-(3-rnethyl-4-(6,9-methanooctahydro 1 H-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrirnidin-2-arnine; 4-(6-(2-oxa-5-azabicycio[2.2.1]heptan-5-yl)pyridin-3-yl)-/V-(3-methyl-4-(1,4- diazabicyclo[3.2.2]nonan-4-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-cyano-4-(3,9-diazabicyclo[3.3.2]decan-10-on-3- yl)phenyl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2H-pyrido[3,2-b][1l4]oxazin-7-yl)-/V-(3-cyano-4-(3,9- diazabicyclo[3.3.2]decan-10-on-3-yl)phenyl)pyrimidin-2-amine; 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-rnethyl-4-(3-(dimethylamino)-8-azabicyclo[3.2.1 ]octan-8-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(3-(morpholin-4-yl)-8- azabicyclo[3.2.1]octan-8-yl)phenyl)pyrimidin-2-amine; 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-methyl-4-(3-(morpholin-4-yl)-8- azabicyclo[3.2.1]octan-8-yl)phenyl)pyrimidin-2-amine; 4-(6-(morpholin~4-yl)pyridin-3-yl)-/V-(3-methyl-4-(3-(dimethylarnino)-8- azabicyclo[3.2.1]octan-8-yl)phenyl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin»3-yl)-/V-(6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(methylcarbonylamino)pyridin-3-yi)-/V-(4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(4-(dimethyfamino)phenyl)-A/-(6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3- yl)pyrimidin-2-amine; 4-(6-(4-acetylpiperazin-1-yl)pyridin-3-yl)-N-(6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(5^θ^Ι-6-(™οΓρΚοΙίη-4^Ι^πάίη-3-^)-Λ/-(6-(5-ΠΊΘΐϊψΙ-215-άΪ3Ζ3ό^οΙο[2.2.1]ήθρί3η- 2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(dimethylamino)pyridin-3-yl)-A/-(5-methyl-6-(5-methyl-2,5~diazabicyclo[2.2.1]heptan- 2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(4-(dimethylamino)phenyl)-A/-(5-methyl-6-((5-methyl-2,5-diazabicyclo[2.2.1jheptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(4-acetyipiperazin-1-yl)pyridin-3-yt)-A/-(5-methyl-6-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 139 140 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-N-(5-methyl’6-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(4-methyl-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(5~methyl-6-(5-methyl-2,5- diazabicycfo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/\/-(5-methyl-6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan- 2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(4-(f-butylcarbonylamino)phenyl)-A/-(5-methyl-6-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-y!)-A/-(5-methyl-6-(5- methyl-2l5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(4-(3-cyclopropylureido)phenyl)-A/-(5-methyl-6-(5-methyl-2,5-diazabicycloi2.2.1]heptan- 2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-N-(5-methyl-6-(5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-aminopyridin-3-yl)-A/-(5-methyl-6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(acetamido)pyridin-3-yl)-/V-(5-methyl-6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(5-methyl-6-(5-methyl-2,5- diazabicycfo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine; 4-(2-(dimethylamino)thiazol-4-yl)-A/-(6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(5-(morpholin-4-yl)pyrazin-2-yl)-A/-(6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)pyridin-3-yl)pyrimidin-2-amine; 4-(1-(pyridin-4-yl)-1H-indol-5-yl)-A/-(5-methyl-6-(5-methyl-2l5-diazabicyclo[2.2.1]heptan- 2-yl)pyridin-3-yl)pyrimidin-2-amine; and 4-(6-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyridin-3-yl)-/V-(5-methyl-6-(5-methyl~2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine.

It is understood that the various embodiments of the compounds of the invention, as set forth above, do not encompass compounds which are specifically disclosed in prior publications, including scientific journals, patents and published patent applications.

Another aspect of the invention are pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a compound of the invention, as set forth above in the Summary of the Invention, as an isolated stereoisomer or a mixture thereof, or as a pharmaceutically acceptable salt 140 141 thereof. In particular, some embodiments of the pharmaceutical compositions of the invention comprise a pharmaceutically acceptable excipient and a therapeutically effective amount of an embodiment of a compound of formula (I), as set forth above.

More specific embodiments are pharmaceutical compositions comprising a 5 pharmaceutically acceptable excipient and a therapeutically effective amount of a compound of formula (la), as set forth above.

Another aspect of the invention are methods of treating diseases or conditions associated with JAK2 activity in a mammal utilizing the compounds and the pharmaceutical compositions of the invention. One embodiment of the methods of the 10 invention disclosed herein is the administration of a therapeutically effective amount of a compound of formula (la), as set forth above, to a mammal, preferably a human, in need thereof. Another embodiment of the methods of the invention disclosed herein are methods of treating the diseases or conditions associated with JAK2 activity in a mammal wherein the disease or conditions is leukemia, lymphoma, multiple myeloma, 15 transplant rejection, bone marrow transplant applications, autoimmune diseases, inflammation, myeloproliferative disorders, polycythemia vera disorder, essential thrombocythemia disorder and primary myelofibrosis.

It is understood that any embodiment of the compounds of the invention, as set forth above, and any specific substituent set forth herein for a particular n, m, R1, R2, R3, 20 R4, R5 or Y in the compounds of the invention, as set forth above, may be independently combined with other embodiments and/or substituents of compounds of the invention to form embodiments of the inventions not specifically set forth above. In addition, in the event that a list of substituents is listed for any particular R group or Y in a particular embodiment and/or claim, it is understood that each individual substituent may be 25 deleted from the particular embodiment and/or claim and that the remaining list of substituents will be considered to be within the scope of the invention.

Specific embodiments of the invention are described in more detail below in the following sections.

UTILITY AND TESTING OF THE COMPOUNDS OF THE INVENTION 30 The present invention provides pyrimidine-2-amine compounds or pharmaceutically acceptable salts thereof, as described above in the Summary of the Invention, for use in treating the diseases or conditions as described herein. The present invention further provides use of the compounds of the present invention in the manufacture of a medicament for the treatment of diseases or conditions in which 141 142 targeting of the JAK pathway or inhibition of JAK kinases, particularly JAK2, can be therapeutically useful. These include diseases or conditions where the function of lymphocytes, macrophages, or mast cells is involved. Accordingly, diseases or conditions associated with JAK2 activity, in particular, are diseases or conditions in 5 which targeting of the JAK pathway or inhibition of the JAK kinases, particularly JAK2, can be therapeutically useful include, but are not limited to, leukemia, lymphoma, multiple myeloma, transplant rejection (e.g. pancreas islet transplant rejection), bone marrow transplant conditions (e.g., graft-versus-host disease), autoimmune diseases (e.g., rheumatoid arthritis), inflammation (e.g., asthma, etc.), myeloproliferative disorders 10 (MPD) (e.g., polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF)), and other diseases or conditions as described in greater detail herein or which are known to one skilled in the art as being associated with JAK2 activity.

As noted previously, numerous diseases or conditions can be treated using the 15 compounds of the invention, or pharmaceutically acceptable salts thereof, and pharmaceutically compositions comprising the compounds or pharmaceutically acceptable salts thereof. As well understood in the art, "treatment" is an approach for obtaining beneficial or desired results, including clinical results. For the purposes of this invention, beneficial or desired results can include one or more, but are not limited to: 20 alleviation or amelioration of one or more symptoms; diminishment of extent of a condition, including a disease; stabilization (i.e., not worsening) of the state of a condition, including diseases; preventing spread of disease; delay or slowing of a condition, including disease progression; amelioration or palliation of the condition, including disease state; and remission (whether partial or total); in each case whether 25 detectable or undetectable. Preferred are compounds that are potent and can be administered locally at very low doses, thus minimizing systemic adverse effects.

The compounds of the invention, or pharmaceutically acceptable salts thereof, described herein are potent and selective inhibitors of JAK kinases, and particularly selective for cytokine signaling pathways containing JAK2. As a consequence of this 30 activity, the compounds can be used in a variety of in vitro, in vivo and ex vivo contexts to regulate or inhibit JAK kinase activity, signaling cascades in which JAK kinases play a role, and the biological responses effected by such signaling cascades. For example, in one embodiment, the compounds can be used to inhibit JAK kinase, either in vitro or in vivo, in virtually any cell type expressing the JAK kinase. 35 In hematopoietic cells in which a JAK kinase is expressed, the compounds of the 142

I 143 invention may be used to regulate signal transduction cascades in which the JAK kinase, particularly JAK2, plays a role. Such JAK-dependent signal transduction cascades include, but are not limited to, the signaling cascades of a wide range of cytokine receptors, including those activated by growth hormone, erythropoietin, prolactin, granulocyte colony stimulating factor (G-CSF), macrophage colony-stimulating factor, ciliary neurotrophic factor, leukemia inhibitory factor, oncostatin M, interferon-y, thrombopoietin, leptin, IL-3, IL-5, IL-6, IL-11, IL-12 and some G-protein-coupled (GPCR) receptor signaling cascades (angiotensin II, bradykinin, endothelin, platelet activating factor, α-melanocyte stimulating hormone, isoproterenol, and phenylephrine). The compounds may also be used in vitro or in vivo to regulate, and in particular inhibit, cellular or biological responses affected by such JAK-dependent signal transduction cascades. Such cellular or biological responses include, but are not limited to, MAPK and AKT pathway activation, IL-3 mediated cell proliferation, etc.

Importantly, the compounds can be used to inhibit JAK kinases in vivo as a therapeutic approach towards the treatment or prevention of diseases or conditions mediated, either wholly or in part, by a JAK kinase activity (referred to herein as "JAK kinase mediated diseases or conditions"). Non-limiting examples of JAK kinase mediated diseases or conditions that can be treated or prevented with the compounds of the invention, or pharmaceutically acceptable salts thereof, include, but are not limited to: allergies; asthma; autoimmune diseases such as transplant rejection (e.g., kidney, heart, lung, liver, pancreas, skin; host versus graft reaction (HVGR), graft versus host reaction (GVHR) etc.), rheumatoid arthritis, and amyotrophic lateral sclerosis; T-cell mediated autoimmune diseases such as multiple sclerosis, psoriasis and Sjogren’s syndrome; Type II inflammatory diseases such as vascular inflammation (including vasculitis, arteritis, atherosclerosis and coronary artery disease); diseases of the central nervous system such as stroke; pulmonary diseases such as bronchitis obliteraus, primary pulmonary hypertension and pulmonary arterial hypertension, and solid, delayed Type IV hypersensitivity reactions; and hematologic malignancies such as leukemia and lymphomas. The compounds of the invention may also be used for treatment of obesity, since in obese animals, JAK2/STAT and MAP kinase pathways are hyperactivated in response to insulin.

This invention also provides a method of inhibiting an activity of a JAK kinase, comprising contacting the JAK kinase with an amount of a compound effective to inhibit an activity of the JAK kinase wherein the compound is selected from the compounds of this invention or pharmaceutically acceptable salts thereof. In certain embodiments of 143 144 the methods described herein, the method is carried out in vivo. In certain embodiments of the methods described herein, the method is carried out in vitro.

In certain embodiments of the methods, the compound is administered to a subject suffering from a T-cell mediated autoimmune disease. In some other embodiments, the subject is a transplant recipient suffering from or predisposed to an allograft transplant rejection. In some other embodiments, the compound is administered to a subject suffering from or predisposed to develop a Type IV hypersensitivity reaction.

This invention also provides a method of inhibiting an activity of a JAK kinase, comprising contacting in vitro a JAK2 kinase with anamountofa compound effective to inhibit an activity of the JAK kinase wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof.

In a specific embodiment, the compounds of the invention, or pharmaceutically acceptable salts thereof, can be used to treat and/or prevent rejection in organ and/or tissue transplant recipients (/. e., treat and/or prevent allograft rejection). Allografts can be rejected through either a cell-mediated or humoral immune reaction of the recipient against transplant (histocompatibility) antigens present on the membranes of the donor’s cells. The strongest antigens are governed by a complex of genetic loci termed human leukocyte group A (HLA) antigens. Together with the ABO blood groups antigens, they are the chief transplantation antigens detectable in humans.

Rejection following transplantation can generally be broken into three categories: hyperacute, occurring hours to days following transplantation; acute, occurring days to months following transplantation; and chronic, occurring months to years following transplantation.

Hyperacute rejection is caused mainly by the production of host antibodies that attack the graft tissue. In a hyperacute rejection reaction, antibodies are observed in the transplant vascular very soon after transplantation. Shortly thereafter, vascular clotting occurs, leading to ischemia, eventual necrosis and death. The graft infarction is unresponsive to known immunosuppressive therapies. Because HLA antigens can be identified in vitro, pre-transplant screening is used to significantly reduce hyperacute rejection. As a consequence of this screening, hyperacute rejection is relative uncommon today.

Acute rejection is thought to be mediated by the accumulation of antigen specific cells in the graft tissue. The T-cell-mediated immune reaction against these antigens (i.e., HVGR or GVHR) is the principle mechanism of acute rejection. Accumulation of these cells leads to damage of the graft tissue. It is believed that both CD4+ helper T- 144 145 cells and CD8+ cytotoxic T-cells are involved in the process, and that the antigen is presented by donor and host dendritic cells. The CD4+ helper T-cells help recruit other effector cells, such as macrophages and eosinophils, to the graft. Accessing T-cell activation signal transduction cascades (for example, CD28, CD40L and CD2 cascades) 5 are also involved.

The cell-mediated acute rejection can be reversed in many cases by intensifying immunotherapy. After successful reversal, severely damaged elements of the graft heal by fibrosis and the remainder of the graft appears normal. After resolution of acute rejection, dosages of immunosuppressive drugs can be reduced to very low levels. 10 Chronic rejection, which is a particular problem in renal transplants, often progresses insidiously despite increased immunosuppressive therapy. It is thought to be due, in large part, to cell-mediated Type IV hypersensitivity. The pathologic profile differs from that of acute rejection. The arterial endothelium is primarily involved, with extensive proliferation that may gradually occlude the vessel lumen, leading to ischemia, fibrosis, a 15 thickened intima and atherosclerotic changes. Chronic rejection is mainly due to a progressive obliteration of graft vasculature, and resembles a slow, vasculitic process.

In Type IV hypersensitivity, CD8 cytotoxic T-cells and CD4 helper T cells recognize either intracellular or extracellular-synthesized antigen when it is complexed, respectively, with either Class I or Class II MHC molecules. Macrophages function as 20 antigen-presenting cells and release IL-1, which promotes proliferation of helper T-cells. Helper T-cells release interferon gamma and IL-2, which together regulate delayed hyperactivity reactions mediated by macrophage activation and immunity mediated by T cells. In the case of organ transplant, the cytotoxic T-cells destroy the graft cells on contact. 25 Since JAK kinases play a critical role in the activation of T-cells, the pyrimidine-2- amine compounds or pharmaceutically acceptable salts thereof described herein can be used to treat and/or prevent many aspects of transplant rejection, and are particularly useful in the treatment and/or prevention of rejection reactions that are mediated, at least in part, by T-cells, such as HVGR or GVHR. The pyrimidine-2-amine compounds can 30 also be used to treat and/or prevent chronic rejection in transplant recipients, and in particular in renal transplant recipients.

This invention also provides a method of treating a T-cell mediated autoimmune disease, comprising administering to a patient suffering from such an autoimmune disease an amount of a compound effective to treat the autoimmune disease wherein the 35 compound is selected from the compounds of the invention or pharmaceutically 145 146 acceptable salts thereof. In certain embodiments of the methods the autoimmune disease is multiple sclerosis (MS), psoriasis, or Sjogren’s syndrome.

Therapy using the pyrimidine-2-amine compounds, or pharmaceutically acceptable salts thereof, described herein can be applied alone, or they can be applied 5 in combination with or adjunctive to other common immunosuppressive therapies, such as, for example, mercaptopurine, corticosteroids such as prednisone, methylprednisolone and prednisolone, alkylating agents such as cyclophosphamide, calcineurin inhibitors such as cyclosporine, sirolimus and tacrolimus, inhibitors of inosine monophosphate dehydrogenase (IMPDH) such as mycophenolate, mycophenolate 10 mofetil and azathioprine, and agents designed to suppress cellular immunity while leaving the recipient’s humoral immunologic response intact, including various antibodies (for example, antilymphocyte globulin (ALG), antithymocyte globulin (ATG), monoclonal anti-T-celi antibodies (OKT3)) and irradiation. These various agents can be used in accordance with their standard or common dosages, as specified in the prescribing 15 information accompanying commercially available forms of the drugs (see also, the prescribing information in the 2006 Edition of The Physician’s Desk Reference), the disclosures of which are incorporated herein by reference. Azathioprine is currently available from Salix Pharmaceuticals, Inc. under the brand name AZASAN; mercaptopurine is currently available from Gate Pharmaceuticals, Inc. under the brand 20 name PURINETHOL; prednisone and prednisolone are currently available from Roxane Laboratories, Inc.; Methyl prednisolone is currently available from Pfizer; sirolimus (rapamycin) is currently available from Wyeth-Ayerst under the brand name RAPAMUNE; tacrolimus is currently available from Fujisawa under the brand name PROGRAF; cyclosporine is current available from Novartis under the brand dame 25 SANDIMMUNE and Abbott under the brand name GENGRAF; IMPDH inhibitors such as mycophenolate mofetil and mycophenolic acid are currently available from Roche under the brand name CELLCEPT and Novartis under the brand name MYFORTIC; azathioprine is currently available from Glaxo Smith Kline under the brand name IMURAN; and antibodies are currently available from Ortho Biotech under the brand 30 name ORTHOCLONE, Novartis under the brand name SIMULECT (basiliximab) and Roche under the brand name ZENAPAX (daclizumab).

In addition, the pyrimidine-2-amine compounds of the invention could be administered either in combination or adjunctively with an inhibitor of a Syk kinase. Syk kinase is a tyrosine kinase known to play a critical role in Fey receptor signaling, as well 35 as in other signaling cascades, such as those involving B-Cell receptor signaling (Turner 146 147 et al., (2000), immunology Today 21:148-154) and integrins beta(1), beta (2) and beta (3) in neutrophils (Mocsavi et al., (2002), immunity 16:547-558). For example, Syk kinase plays a pivotal role in high affinity IgE receptor signaling in mast cells that leads to activation and subsequent release of multiple chemical mediators that trigger allergic 5 attacks. However, unlike the JAK kinases, which help regulate the pathways involved in delayed, or cell-mediated Type IV hypersensitivity reactions, Syk kinase helps regulate the pathways involved in immediate IgE-mediated, Type I hypersensitivity reactions. Certain compounds that affect the Syk pathway may or may not also affect the JAK pathways. 10 Suitable Syk inhibitory compounds are described, for example, in U.S. Patent

Application, Serial No. 10/355,543, filed January 31, 2003 (publication no. 2004/0029902); PCT Published Patent Application No. WO 03/063794; U.S. Patent Application, Serial No. 10/631,029, filed July 29, 2003; PCT Published Patent Application No. WO 2004/014382; U.S. Patent Application, Serial No. 10/903,263, filed July 30, 15 2004; PCT Published Patent Application No. WO 2005/016893; U.S. Patent Application,

Serial No. 10/903,870, filed July 30, 2004; PCT Patent Application No. PCT/US2004/24920, filed July 30, 2004; U.S. Patent Application, Serial No. 60/630,808, filed November 24, 2004; U.S. Patent Application, Serial No. 60/645,424, filed January 19, 2005; and U.S. Patent Application, Serial No. 60/654,620, filed February 18, 2005, 20 the disclosures of which are incorporated herein by reference in their entireties. The pyrimidine-2-amine described herein and Syk inhibitory compounds could be used alone, or in combination with one or more conventional transplant rejection treatments, as described above.

In addition, the pyrimidine-2-amine compounds of the invention, or 25 pharmaceutically acceptable salts thereof, can be used to treat or prevent these diseases or conditions in patients that are either initially non-responsive (resistant) to, or that become non-responsive to treatment with a Syk inhibitory compound, or one of the other current treatments for the particular disease. The pyrimidtne-2-amine compounds of the invention, or pharmaceutically acceptable salts thereof, could also be used in 30 combination with Syk inhibitory compounds in patients that are Syk-compound resistant or non-responsive. Suitable Syk-inhibitory compounds with which the pyrimidine-2-amine compounds of the invention, or pharmaceutically acceptable salts thereof, can be administered are provided supra.

This invention also provides a method of treating a T-cell mediated autoimmune 35 disease, comprising administering to a patient suffering from such an autoimmune 147 148 disease an amount of a compound effective to treat the autoimmune disease wherein the compound is selected from the compounds of the invention, as described herein, or pharmaceutically acceptable salts thereof, and the compound or pharmaceutically acceptable salt thereof is administered in combination with, or adjunctively to, a compound that inhibits Syk kinase with an IC50 in the range of at least 10 μΜ.

This invention also provides a method of treating or preventing allograft transplant rejection in a transplant recipient, comprising administering to the transplant recipient an amount of a compound effective to treat or prevent the rejection wherein the compound is selected from the compounds of the invention, or pharmaceutically acceptable salts thereof, as described herein. In a further embodiment, the compound or pharmaceutically acceptable salt, is administered to a tissue or an organ prior to transplanting the tissue or organ in the transplant recipient.

This invention also provides a method of treating or preventing allograft transplant rejection in a transplant recipient, in which the rejection is acute rejection, comprising administering to the transplant recipient an amount of a compound effective to treat or prevent the rejection wherein the compound is selected from the compounds of the invention, or pharmaceutically acceptable salts thereof.

This invention also provides a method of treating or preventing allograft transplant rejection in a transplant recipient, in which the rejection is chronic rejection, comprising administering to the transplant recipient an amount of a compound effective to treat or prevent the rejection wherein the compound is selected from the compounds of the invention, or pharmaceutically acceptable salts thereof, as described herein.

This invention also provides a method of treating or preventing allograft transplant rejection in a transplant recipient, in which the rejection is mediated by HVGR or GVHR, comprising administering to the transplant recipient an amount of a compound effective to treat or prevent the rejection wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein.

This invention also provides a method of treating or preventing allograft transplant rejection in a transplant recipient, in which the allograft transplant is selected from a kidney, a heart, a liver and a lung, comprising administering to the transplant recipient an amount of a compound effective to treat or prevent the rejection wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein.

This invention also provides a method of treating or preventing allograft 148 149 transplant rejection in a transplant recipient, in which the allograft transplant is selected from a kidney, a heart, a liver and a lung, comprising administering to the transplant recipient an amount of a compound effective to treat or prevent the rejection wherein the compound is selected from the compounds of the invention, or pharmaceutically 5 acceptable salts thereof, as described herein, in which the compound or pharmaceutically acceptable salt is administered in combination with, or adjunctively to, another immunosuppressant.

This invention also provides a method of treating or preventing allograft transplant rejection in a transplant recipient, in which the allograft transplant is selected 10 from a kidney, a heart, a liver and a lung, comprising administering to the transplant recipient an amount of a compound effective to treat or prevent the rejection wherein the compound is selected from the compounds of the invention, or pharmaceutically acceptable salts thereof, as described herein, in which the compound or pharmaceutically acceptable salts is administered in combination with, or adjunctively to, 15 another immunosuppressant, in which the immunosuppressant is selected from cyclosporine, tacrolimus, sirolimus, an inhibitor of IMPDH, mycophenolate, mycophanolate mofetil, an anti-T-Cell antibody and OKT3.

The pyrimidine-2-amine compounds of the invention, or pharmaceutically acceptable salts thereof, described herein are cytokine moderators of IL-4 signaling. As 20 a consequence, the pyrimidine-2-amine compounds of the invention, or pharmaceutically acceptable salts thereof, could slow the response of Type I hypersensitivity reactions. Thus, in a specific embodiment, the pyrimidine-2-amine compounds of the invention, or pharmaceutically acceptable salts thereof, could be used to treat such reactions, and therefore the diseases associated with, mediated by or caused by such hypersensitivity 25 reactions (for example, allergies), prophylactically. For example, an allergy sufferer could take one or more of the JAK selective compounds described herein prior to expected exposure to allergens to delay the onset or progress, or eliminate altogether, an allergic response.

When used to treat or prevent such diseases, the pyrimidine-2-amine compounds 30 of the invention, or pharmaceutically acceptable salts thereof, can be administered singly, as mixtures of one or more pyrimidine-2-amine compounds, or pharmaceutically acceptable salts thereof, or in mixture or combination with other agents useful for treating such diseases and/or the symptoms associated with such diseases. The pyrimidine-2-amine compounds, or pharmaceutically acceptable salts thereof, may also be 35 administered in mixture or in combination with agents useful to treat other disorders or 149 150 maladies, such as steroids, membrane stabilizers, 5-lipoxygenase (5LO) inhibitors, leukotriene synthesis and receptor inhibitors, inhibitors of IgE isotype switching or IgE synthesis, IgG isotype switching or IgG synthesis, β-agonists, tryptase inhibitors, aspirin, cyclooxygenase (COX) inhibitors, methotrexate, anti-TNF drugs, retuxin, PD4 inhibitors, 5 p38 inhibitors, PDE4 inhibitors, and antihistamines, to name a few. The pyrimidine-2- amine compounds, or pharmaceutically acceptable salts thereof, can be administered perse, or in the form of prodrugs or as pharmaceuticai compositions comprising an active compound.

This invention also provides a method of treating or preventing a Type IV 10 hypersensitivity reaction, comprising administering to a subject an amount of a compound of effective to treat or prevent the hypersensitivity reaction wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein.

This invention also provides a method of treating or preventing a Type IV 15 hypersensitivity reaction, which is practical prophylactically, comprising administering to a subject an amount of a compound of effective to treat or prevent the hypersensitivity reaction wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein, and is administered prior to exposure to an allergen. 20 This invention also provides a method of inhibiting a signal transduction cascade in which JAK2 kinase plays a role, comprising contacting a cell expressing a receptor involved in such a signaling cascade with a compound wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein. 25 In another embodiment, this invention provides a method of treating or preventing a JAK kinase-mediated disease, comprising administering to a subject an amount of compound effective to treat or prevent the JAK kinase-mediated disease wherein the compound is selected from the compounds of this invention, or pharmaceutically acceptable salts thereof, as described herein. 30 This invention also provides a method of treating or preventing a JAK kinase- mediated disease, in which the JAK-mediated disease is HVGR or GVHR, comprising administering to a subject an amount of compound effective to treat or prevent the JAK kinase-mediated disease wherein the compound is selected from the compounds of the invention, or pharmaceutically acceptable salts thereof, as described herein. 35 This invention also provides a method of treating or preventing a JAK kinase- 150 151 mediated disease, in which the JAK-mediated disease is acute allograft rejection, comprising administering to a subject an amount of compound effective to treat or prevent the JAK kinase-mediated disease wherein the compound is selected from the compounds of the invention, or pharmaceutically acceptable salts thereof, as described herein.

This invention also provides a method of treating or preventing a JAK kinase-mediated disease, in which the JAK-mediated disease is chronic allograft rejection, comprising administering to a subject an amount of compound effective to treat or prevent the JAK kinase-mediated disease wherein the compound is selected from the compounds of the invention, or pharmaceutically acceptable salts thereof, as described herein.

Active compounds of the invention, or pharmaceutically acceptable salts thereof, typically inhibit the JAK/Stat pathway. The activity of a specified compound as an inhibitor of a JAK kinase can be assessed in vitro or in vivo. In some embodiments, the activity of a specified compound can be tested in a cellular assay. Suitable assays include assays that determine inhibition of either the phosphorylation activity or ATPase activity of a JAK kinase. Thus, a compound is said to inhibit an activity of a JAK kinase if it inhibits the phosphorylation or ATPase activity of a JAK kinase with an IC50 of about 20 μΜ or less,

One means of assaying for such inhibition is detection of the effect of the pyrimidine-2-amine compounds on the upregulation of downstream gene products. In the Ramo$/IL4 assay, B-cells are stimulated with the cytokine lnterleukin-4 (IL-4) leading to the activation of the JAK/Stat pathway through phosphorylation of the JAK family kinases, JAK1 and JAK3, which in turn phosphorylate and activate the transcription factor Stat-6. One of the genes upregulated by activated Stat-6 is the low affinity IgE receptor, CD23. To study the effect of inhibitors (e.g., the pyrimidine-2-amine compounds described herein) on the JAK1 and JAK3 kinases, human Ramos B cells are stimulated with human IL-4. Twenty to 24 hours post stimulation, cells are stained for upregulation of CD23 and analyzed using flow cytometry (FACS). A reduction of the amount of CD23 present compared to control conditions indicates the test compound actively inhibits the JAK kinase pathway. An exemplary assay of this type is described in greater detail in the Biological Examples described below.

The biological activity of the compounds of the invention may further be characterized by assaying the effect of the pyrimidine-2-amine compounds described herein on the proliferative response of primary human T-cells. In this assay, primary 151 152 human T-cells derived from peripheral blood and pre-activated through stimulation of the T-cell receptor and CD28, proliferate in culture in response to the cytokine lnterleukin-2 (IL-2). This proliferative response is dependent on the activation of JAK1 and JAK3 tyrosine kinases, which phosphorylate and activate the transcription factor Stat-5. The 5 primary human T-cells are incubated with the pyrimidine-2-amine compounds in the presence of IL-2 for 72 hours and at the assay endpoint intracellular ATP concentrations are measured to assess cell viability. A reduction in cell proliferation compared to control conditions is indicative of inhibition of the JAK kinase pathway. An exemplary assay of this type is described in greater detail in the Biological Examples described below. 10 The biological activity of the compounds of the invention may additionally be characterized by assaying the effect of the pyrimidine-2-amine compounds described herein on A549 lung epithelial cells and U937 cells. A549 lung epithelial cells and U937 cells up-regulate I CAM-1 (CD54) surface expression in response to a variety of different stimuli. Therefore, using ICAM-1 expression as readout, test compound effects on 15 different signaling pathways can be assessed in the same cell type. Stimulation with IL-1β through the IL-1 β receptor activates the TRAF6 / NFkB pathway resulting in upregulation of ICAM-1. IFNy induces ICAM-1 up-regulation through activation of the JAK1/JAK2 pathway. The up-regulation of ICAM-1 can be quantified by flow cytometry across a compound dose curve and EC50 values are calculated. An exemplary assay of 20 this type is described in greater detail in the Biological Examples described below.

Biologically active compounds of the invention, or pharmaceutically acceptable salts thereof, generally inhibit the JAK kinase pathway with an IC50 in the range of about 1 mM or less, as measured in the assays described herein. Of course, skilled artisans will appreciate that compounds which exhibit lower IC5oS, for example on the order of 100 25 μΜ, 75 μΜ, 50 μΜ, 40 μΜ, 30 μΜ, 20 μΜ, 15 μΜ, 10 μΜ, 5 μΜ, 1 μΜ, 500 ηΜ, 100 ηΜ, 10 ηΜ, 1 ηΜ, or even lower, can be particularly useful in therapeutic applications. In instances where activity specific to a particular cell type is desired, the compound can be assayed for activity with the desired cell type and counter-screened for a lack of activity against other cell types. The desired degree of "inactivity" in such counter screens, or 30 the desired ratio of activity vs. inactivity may vary for different situations, and can be selected by the user.

The pyrimidine-2-amine active compounds of the invention, or pharmaceutically acceptable salts thereof, also typically inhibit IL-4 stimulated expression of CD23 in B-cells with an IC5O in the range of about 20 μΜ or less, typically in the range of about 10 35 pM, 1 pM, 500 nM, 100 nM, 10 nM, 1 nM, or even lower. A suitable assay that can be 152 153 used is the assay described in the Biological Example 1 described below, entitled "Assay for Ramos B-Cell Line Stimulated with IL-4." In certain embodiments, the active pyrimidine-2-amine compounds of the invention have an IC50 of less than or equal to 5 pM, greater than 5 μΜ but less than 20 pM, greater than 20 pM, or greater than 20 pM but less than 50 pM in the assay described in Biological Example 1.

Additionally, the pyrimidine-2-amine active compounds of the invention, or pharmaceutically acceptable salts thereof, also typically inhibit an activity of an human primary T-cells with an IC50 in the range of about 20 pM or less, typically in the range of about 10 pM, 1 pM, 500 nM, 100 nM, 10 nM, 1 nM, or even lower. The IC50 against human primary T-cells can be determined in a standard in vitro assay with isolated human primary T-cells. A suitable assay that can be used is the assay described in the Biological Example 2 below, entitled "Primary Human T-cell Proliferation Assay Stimulated with IL-2." In certain embodiments, the active pyrimidine-2-amine compounds have an IC50 of less than or equal to 5 pM, greater than 5 pM but less than 20 pM, greater than 20 pM, or greater than 20 pM but less than 50 pM in the assay described in Biological Example 2.

The pyrimidine-2-amine active compounds of the invention, or pharmaceutically acceptable salts thereof, also typically inhibit expression of ICAM1 (CD54) induced by IFNy exposure in U937 or A549 cells with an IC50 in the range of about 20 pM or less, typically in the range of about 10 pM, 1 pM, 500 nM, 100 nM, 10 nM, 1 nM, or even lower. The IC50 against expression of ICAM (CD54) in IFNy stimulated cells can be determined in a functional cellular assay with an isolated A549 or U937 cell line.

Suitable assays that can be used are the assays described in Biological Examples 5 and 6 below, entitled "A549 Epithelial Line Stimulated with IFNy," and "U937 IFNy ICAM1 FACS Assay," respectively. In certain embodiments, the active pyrimidine-2-amine compounds have an IC50 of less than or equal to 20 pM, greater than 20 pM, or greater than 20 pM but less than 50 pM in the assays described in Biological Example 5 or Biological Example 6.

For purposes of this invention, the phrase "cell proliferative disorder" refers to a disorder characterized by'abnormal proliferation of cells. A cell proliferative disorder does not imply any limitation with respect to the rate of cell growth, but merely indicates loss of normal controls that affect growth and cell division. Thus, in some embodiments, cells of a cell proliferative disorder can have the same cell division rates as normal cells but do not respond to signals that limit such growth. Within the ambit of "cell proliferative disorder" is neoplasm or tumor, which is an abnormal growth of tissue. Cancer refers to 153 154 any of various malignant neoplasms characterized by the proliferation of cells that have the capability to invade surrounding tissue and/or metastasize to new colonization sites.

Accordingly, cell proliferative disorders treatable with the compounds of the invention, or pharmaceutically acceptable salts thereof, relate to any disorder characterized by aberrant cell proliferation. These include various tumors and cancers, benign or malignant, metastatic or non-metastatic. Cell proliferative disorders include a variety of cancers, including, among others, cancer of the tongue, mouth, pharynx, esophagus, stomach, small intestine, colon, rectum, anus, liver, gallbladder, pancreas, larynx, lung and bronchus, bones and joints including synovial sarcoma and osteosarcoma, melanomas including basal cell carcinoma, squamous carcinoma, breast, cervix, endometrium, ovary, vulva, vagina, prostate, testis, penis, urinary bladder, kidney and renal pelvis, ureter, eye, brain including glioma, glioblastoma, astrocytoma, neuroblastoma, medulloblastoma, and thyroid. For example, cell proliferative disorders treatable with the compounds of the invention, or pharmaceutically acceptable salts thereof, include, but are not limited to, the following: a) proliferative disorders of the breast, which include, but are not limited to, invasive ductal carcinoma, invasive lobular carcinoma, ductal carcinoma, lobular carcinoma in situ and metastatic breast cancer; b) proliferative disorders of the skin, which include, but are not limited to, basal cell carcinoma, squamous cell carcinoma, malignant melanoma and Karposi’s sarcoma; c) proliferative disorders of the respiratory tract, which include, but are not limited to, small cell and non-small cell lung carcinoma, bronchial adema, pleuropuimonary blastoma and malignant mesothelioma; d) proliferative disorders of the brain, which include, but are not limited to, brain stem and hyptothalamic glioma, cerebellar and cerebral astrocytoma, medullablastoma, ependymal tumors, oligodendroglial, meningiomas and neuroectodermal and pineal tumors; e) proliferative disorders of the male reproductive organs, which include, but are not limited to, prostate cancer, testicular cancer and penile cancer; f) proliferative disorders of the female reproductive organs, which include, but are not limited to, uterine cancer (endometrial), cervical, ovarian, vaginal, vulval cancers, uterine sarcoma and ovarian germ cell tumor; g) proliferative disorders of the digestive tract, which include, but are not limited to, anal, colon, colorectal, esophageal, gallbladder, stomach (gastric), pancreatic 154 155 cancer, pancreatic cancer- Islet cell, rectal, small-intestine and salivary gland cancers; h) proliferative disorders of the liver, which include, but are not limited to, hepatocellular carcinoma, cholangiocarcinoma, mixed hepatocellular cholangiocarcinoma, primary liver cancer and metastatic liver cancer; i) proliferative disorders of the eye, which include, but are not limited to, intraocular melanoma, retinoblastoma, and rhabdomyosarcoma; j) proliferative disorders of the head and neck, which include, but are not limited to, laryngeal, hypopharyngeal, nasopharyngeal, oropharyngeal cancers, and lip and oral cancer, squamous neck cancer, metastatic paranasal sinus cancer; k) proliferative disorders of lymphocytic cells, which include, but are not limited to, various T cell and B cell lymphomas, non-Hodgkins lymphoma, cutaneous T cell lymphoma, Hodgkins disease, and lymphoma of the central nervous system; l) leukemias, which include, but are not limited to, acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, and hairy cell leukemia, m) proliferative disorders of the thyroid, which include, but are not limited to, thyroid cancer, thymoma, malignant thymoma, medullary thyroid carcinomas, papillary thyroid carcinomas, multiple endocrine neoplasia type 2A (MEN2A), pheochromocytoma, parathyroid adenomas, multiple endocrine neoplasia type 2B (MEN2B), familial medullary thyroid carcinoma (FMTC) and carcinoids; n) proliferative disorders of the urinary tract, which include, but are not limited to, bladder cancer; o) sarcomas, which include, but are not limited to, sarcoma of the soft tissue, osteosarcoma, malignant fibrous histiocytoma, lymphosarcoma, and rhabdomyosarcoma; p) proliferative disorders of the kidneys, which include, but are not limited to, renal cell carcinoma, clear cell carcinoma of the kidney; and renal cell adenocarcinoma; q) precursor B-lymphobiastic leukemia/lymphoma (precursor B-cell acute lymphoblastic leukemia), B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma, B-cell prolymphocytic leukemia, lymphoplasmacytic lymphoma, splenic marginal zone B-cell lymphoma, hairy cell leukemia, plasma cell myeioma/plasmacytoma, extranodal marginal zone B-cell lymphoma of MALT type, nodal marginal zone B-cell lymphoma, follicular lymphoma, mantle-cell lymphoma, diffuse large B-cell lymphoma, mediastinal large B-cell lymphoma, primary effusion lymphoma and Burkitt's lymphoma/Burkitt cell leukemia 155 156 (r) precursor T-lymphoblastic lymphoma/leukemia (precursor T-cell acute lymphoblastic leukemia), T-cell prolymphocytic leukemia, T-cell granular lymphocytic leukemia, aggressive NK-cell leukemia, adult T-cell lymphoma/leukemia (HTLV-1), extranodal NK/T-cell lymphoma, nasal type, enteropathy-type T-cell lymphoma, hepatosplenic gamma-delta T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, mycosis fungoides/Sezary syndrome, anaplastic large-cell lymphoma, T/nul! cell, primary cutaneous type, peripheral T-cell lymphoma, not otherwise characterized, angioimmunoblastic T-cel! lymphoma, anaplastic large-cell lymphoma, T/null cell, and primary systemic type; (s) nodular lymphocyte-predominant Hodgkin’s lymphoma, nodular sclerosis Hodgkin's lymphoma (grades 1 and 2), lymphocyte-rich classical Hodgkin’s lymphoma, mixed cellularity Hodgkin’s lymphoma, and lymphocyte depletion Hodgkin's lymphoma; (t) myelogenous leukemia (e.g., Philadelphia chromosome positive (t(9;22)(qq34;q11)), multiple myeloma, chronic neutrophilic leukemia, chronic eosinophilic leukemia/hypereosinophilic syndrome, chronic idiopathic myelofibrosis, polycythemia vera, essential thrombocythemia, chronic myelomonocytic leukemia, atypical chronic myelogenous leukemia, juvenile myelomonocytic leukemia, refractory anemia with ringed sideroblasts and without ringed sideroblasts, refractory cytopenia (myelodysplastic syndrome) with multilineage dysplasia, refractory anemia (myelodysplastic syndrome) with excess blasts, 5q-syndrome, and myelodysplastic syndrome with t(9;12)(q22;p12); (u) AML with t&lt;8;21 )(q22;q22), AML1 (CBF-alpha)/ETO, acute promyelocytic leukemia (AML with t(15;17)(q22;q11-12) and variants, PML/RAR-alpha), AML with abnormal bone marrow eosinophils (inv(16)(p13q22) or t(16;16)(p13;q11), CBFb/MYH11X), and AML with 11q23 (MLL) abnormalities, AML minimally differentiated, AML without maturation, AML with maturation, acute myelomonocytic leukemia, acute monocytic leukemia, acute erythroid leukemia, acute megakaryocytic leukemia, acute basophilic leukemia, and acute panmyelosis with myelofibrosis.

The antiproliferative effect of a combination therapy of the invention may be assessed by administering the compound of the invention to a cultured tumor cell line. In the context of an in vitro assay, administration of a compound of the invention may be simply achieved by contacting the cells in culture with the compound in amounts effective to inhibit cell proliferation. Alternatively, the antiproliferative effect of a compound of the invention may be assessed by administering the compound to an animal in an approved in vivo model for cell proliferation. 156 157

Examples of tumor cell lines derived from human tumors and available for use in the in vivo studies include, but are not limited to, leukemia cell lines (e.g., CCRF-CEM, HL-60(TB), K-562, MOLT-4, RPM1-8226, SR, P388 and P388/ADR); non-smali cell lung cancer cell lines (e.g., A549/ATCC, EKVX, HOP-62, HOP-92, NCI-H226, NCI-H23, NCI-H322M, NCI-H460, NCI-H522 and LXFL 529); small cell lung cancer cell lines (e.g.,DMS 114 and SHP-77); colon cancer cell lines (e.g., COLO 205, HCC-2998, HCT-116, HCT-15, HT29, KM12, SW-620, DLD-1 and KM20L2); central nervous system (CNS) cancer cell lines (e.g., SF-268, SF-295, SF-539, SNB-19, SNB-75, U251, SNB-78 and XF498); melanoma cell lines (e.g., LOX I MVI, MALME-3M, M14, SK-MEL-2, SK-MEL-28, SK-MEL-5, UACC-257, UACC-62, RPMI-7951 and M19-MEL); ovarian cancer cell lines (e.g., IGROV1, OVCAR-3, OVCAR-4, OVCAR-5, OVCAR-8 and SK-OV-3); renal cancer cell lines (e.g., 786-0, A498, ACHN, CAKI-1, RXF 393, SN12C, TK-10, UO-31, RXF-631 and SN12K1); prostate cancer cell lines (e.g., PC-3 and DU-145); breast cancer cell lines (e.g., MCF7, NCI/ADR-RES, MDA-MB-231/ATCC, HS 578T, MDA-MB-435, BT-549, T-47D and MDA-MB-468); and thyroid cancer cell lines (e.g., SK-N-SH).

In some embodiments of the invention, the cell proliferative disorder treated by the compounds of the invention, or pharmaceutically acceptable salts thereof, is a hematopoietic neoplasm, which is aberrant growth of cells of the hematopoietic system. Hematopoietic malignancies can have its origins in pluripotent stem cells, multipotent progenitor cells, oligopotent committed progenitor cells, precursor cells, and terminally differentiated cells involved in hematopoiesis. Some hematological malignancies are believed to arise from hematopoietic stem cells, which have the ability for self renewal. For instance, cells capable of developing specific subtypes of acute myeloid leukemia (AML) upon transplantation display the cell surface markers of hematopoietic stem cells, implicating hematopoietic stem cells as the source of leukemic cells. Blast ceils that do not have a cell marker characteristic of hematopoietic stem cells appear to be incapable of establishing tumors upon transplantation (Blaire et al., 1997, Blood 89:3104-3112). The stem cell origin of certain hematological malignancies also finds support in the observation that specific chromosomal abnormalities associated with particular types of leukemia can be found in normal cells of hematopoietic lineage as well as leukemic blast cells. For instance, the reciprocal translocation t(9q34;22q11) associated with approximately 95% of chronic myelogenous leukemia appears to be present in cells of the myeloid, erythroid, and lymphoid lineage, suggesting that the chromosomal aberration originates in hematopoietic stem cells. A subgroup of cells in certain types of CML displays the cell marker phenotype of hematopoietic stem celts. 157 158

Although hematopoietic neoplasms often originate from stem cells, committed progenitor cells or more terminally differentiated cells of a developmental lineage can also be the source of some leukemias. For example, forced expression of the fusion protein Bcr/Abl (associated with chronic myelogenous leukemia) in common myeloid progenitor or granulocyte/macrophage progenitor cells produces a leukemic-like condition. Moreover, some chromosomal aberrations associated with subtypes of leukemia are not found in the cell population with a marker phenotype of hematopoietic stem cells, but are found in a cell population displaying markers of a more differentiated state of the hematopoietic pathway (Turhan et al., 1995, Blood 85:2154-2161). Thus, while committed progenitor cells and other differentiated cells may have only a limited potential for ceil division, leukemic cells may have acquired the ability to grow unregulated, in some instances mimicking the self-renewal characteristics of hematopoietic stem cells (Passegue et al., Proc. Natl. Acad. Sci. USA, 2003, 100:11842-9).

In some embodiments of the invention, the hematopoietic neoplasm treated by the compounds of the invention, or pharmaceutically acceptable salts thereof, is a lymphoid neoplasm, where the abnormal cells are derived from and/or display the characteristic phenotype of cells of the lymphoid lineage. Lymphoid neoplasms can be subdivided into 3-cell neoplasms, T and NK -cell neoplasms, and Hodgkin’s lymphoma. B-cell neoplasms can be further subdivided into precursor B-cell neoplasm and mature/peripheral B-cell neoplasm. Exemplary B-cell neoplasms are precursor B-lymphoblastic leukemia/lymphoma (precursor B-cell acute lymphoblastic leukemia) while exemplary mature/peripheral B-cell neoplasms are B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma, B-cell prolymphocytic leukemia, lymphoplasmacytic lymphoma, splenic marginal zone B-cell lymphoma, hairy cell leukemia, plasma cell myeloma/plasmacytoma, extranodal marginal zone B-cell lymphoma of MALT type, nodal marginal zone B-cell lymphoma, follicular lymphoma, mantle-cell lymphoma, diffuse large B-cell lymphoma, mediastinal large B-cell lymphoma, primary effusion lymphoma, and Burkitt's lymphoma/Burkitt cell leukemia. T-cell and Nk-cell neoplasms are further subdivided into precursor T-cell neoplasm and mature (peripheral) T-cell neoplasms. Exemplary precursor T-cell neoplasm is precursor T-lymphoblastic lymphoma/leukemia (precursor T-cell acute lymphoblastic leukemia) while exemplary mature (peripheral) T-cell neoplasms are T-cell prolymphocytic leukemia T-cell granular lymphocytic leukemia, aggressive NK-cell leukemia, adult T-cell lymphoma/leukemia (HTLV-1), extranodal NK/T-cell lymphoma, nasal type, enteropathy- 158 159 type T-cell lymphoma, hepatosplenic gamma-delta T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, Mycosis fungoides/Sezary syndrome, Anaplastic largecell lymphoma, T/null cell, primary cutaneous type, Peripheral T-cell lymphoma, not otherwise characterized, Angioimmunoblastic T-cell lymphoma, Anaplastic large-cell lymphoma, T/null cell, primary systemic type. The third member of lymphoid neoplasms is Hodgkin’s lymphoma, also referred to as Hodgkin’s disease. Exemplary diagnosis of this class that can be treated with the compounds of the invention, include, among others, nodular lymphocyte-predominant Hodgkin’s lymphoma, and various classical forms of Hodgkin’s disease, exemplary members of which are Nodular sclerosis Hodgkin’s lymphoma (grades 1 and 2), Lymphocyte-rich classical Hodgkin’s lymphoma, Mixed cellularity Hodgkin’s lymphoma, and Lymphocyte depletion Hodgkin’s lymphoma. In various embodiments, any of the lymphoid neoplasms that are associated with aberrant JAK activity can be treated with the JAK inhibitory compounds.

In some embodiments of the invention, the hematopoietic neoplasm treated by the compounds of the invention, or pharmaceutically acceptable salts thereof, is a myeloid neoplasm, This group comprises a large class of cell proliferative disorders involving or displaying the characteristic phenotype of the cells of the myeloid lineage. Myeloid neoplasms can be subdivided into myeloproliferative diseases, myelodysplastic/myeloproliferative diseases, myelodysplastic syndromes, and acute myeloid leukemias. Exemplary myeloproliferative diseases are chronic myelogenous leukemia (e.g., Philadelphia chromosome positive (t(9;22)(qq34;q11)), chronic neutrophilic leukemia, chronic eosinophilic leukemia/hypereosinophilic syndrome, chronic idiopathic myelofibrosis, polycythemia vera, and essential thrombocythemia, Exemplary myelodysplastic/myeloproliferative diseases are chronic myelomonocytic leukemia, atypical chronic myelogenous leukemia, and juvenile myelomonocytic leukemia. Exemplary myelodysplastic syndromes are refractory anemia, with ringed sideroblasts and without ringed sideroblasts, refractory cytopenia (myelodysplastic syndrome) with multilineage dysplasia, refractory anemia (myelodysplastic syndrome) with excess blasts, 5q- syndrome, and myelodysplastic syndrome. In various embodiments, any of the myeloid neoplasms that are associated with aberrant JAK activity can be treated with the JAK inhibitory compounds.

In some embodiments of the invention, the JAK inhibitory compounds of the invention, or pharmaceutically acceptable salts thereof, can be used to treat acute myeloid leukemias (AML), which represent a large class of myeloid neoplasms having its own subdivision of disorders. These subdivisions include, among others, AMLs with 159 160 recurrent cytogenetic translocations, AML with multilineage dysplasia, and other AML not otherwise categorized. Exemplary AMLs with recurrent cytogenetic translocations include, among others, AML with t(8;21)(q22;q22), AML1(CBF-alpha)/ETO, Acute promyelocytic leukemia (AML with t(15;17)(q22;q11-12) and variants, PML/RAR-alpha), 5 AML with abnormal bone marrow eosinophils (inv(16)(p13q22) or t(16; 16)(p13;q 11), CBFb/MYH11X), and AML with 11q23 (MLL) abnormalities. Exemplary AML with multilineage dysplasia are those that are associated with or without prior myelodysplastic syndrome. Other acute myeloid leukemias not classified within any definable group include, AML minimally differentiated, AML without maturation, AML with maturation, 10 Acute myelomonocytic leukemia, Acute monocytic leukemia, Acute erythroid leukemia, Acute megakaryocytic leukemia, Acute basophilic leukemia, and Acute panmyelosis with myelofibrosis.

Animal models useful for testing the efficacy of compounds to treat or prevent the various diseases or conditions described above are well-known in the art. Suitable 15 animal models of hypersensitivity or allergic reactions are described in Foster, (1995) Allergy 50(21 Suppl) :6-9, discussion 34-38 and Turn as et al., (2001), J. Allergy Clin. /mmuno/. 107(6):1025-1033. Suitable animal models of allergic rhinitis are described in Szelenyi et al., (2000), Arzneimitteiforschung 50(11):1037-42; Kawaguchi et at., (1994), Clin. Exp. Allergy 24(3):238-244 and Sugimoto etal., (2000), Immunopharmacology 20 48(1):1-7. Suitable animal models of allergic conjunctivitis are described in Carreras et al., (1993), Br. J. Ophthalmol. 77(8):509-514; Saiga etal., (1992), Ophthalmic Res. 24(1):45-50; and Kunert etal., (2001), Invest. Ophthalmol. Vis. Sci. 42(11):2483-2489. Suitable animal models of systemic mastocytosis are described in O’Keefe et al., (1987), J. Vet. Intern. Med. 1(2):75-80 and Bean-Knudsen etal., (1989), Vet. Pathol. 26(1):90- 25 92. Suitable animal models of hyper IgE syndrome are described in Claman et at., (1990), Clin. Immunol, tmmunopathot. 56(1):46-53. Suitable animal models of B-cell lymphoma are described in Hough et al., (1998), Proc. Natl. Acad. Sci. USA 95:13853-13858 and Hakim et al., (1996), J. Immunol. 157(12):5503-5511. Suitable animal models of atopic disorders such as atopic dermatitis, atopic eczema and atopic asthma 30 are described in Chan et at., (2001), J. Invest. Dermatol. 117(4):977-983 and Suto et al., (1999), tnt. Arch. Allergy Immunol. 120(Suppl 1):70-75. Suitable animal models of transplant rejection, such as models of HVGR are described in O’Shea et al., (2004), Nature Reviews Drug Discovery 3:555-564; Cetkovic-Curlje &amp;amp; Tibbles, (2004), Current Pharmaceutical Design 10:1767-1784; and Chengelian et at., (2003), Science 302:875- 35 878. Suitable animal models of polycythemia vera, essential thrombocythemia and 160 161 primary myelofibrosis are described in Shimoda, (2008) Leukemia 22(1):87-95; Lacout, (2006) Blood 108(5):1652-60; and Wernig, (2006) Blood 107(11):4274-81.

PHARMACEUTICAL COMPOSITIONS OF THE INVENTION AND ADMINISTRATION

Administration of the compounds of the invention, or their pharmaceutically acceptable salts, in pure form or in an appropriate pharmaceutical composition, can be carried out via any of the accepted modes of administration of agents for serving similar utilities. The pharmaceutical compositions of the invention can be prepared by combining a compound of the invention with an appropriate pharmaceutically acceptable carrier, diluent or excipient, and may be formulated into preparations in solid, semi-solid, liquid or gaseous forms, such as tablets, capsules, powders, granules, ointments, solutions, suppositories, injections, inhalants, gels, microspheres, and aerosols. Typical routes of administering such pharmaceutical compositions include, without limitation, oral, topical, transdermal, inhalation, parenteral, sublingual, buccal, rectal, vaginal, and intranasal. The term parenteral, as used herein, includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques. Pharmaceutical compositions of the invention are formulated so as to allow the active ingredients contained therein to be bioavatlable upon administration of the composition to a patient. Compositions that will be administered to a subject or patient take the form of one or more dosage units where, for example, a tablet may be a single dosage unit, and a container of a compound of the invention in aerosol form may hold a plurality of dosage units. Actual methods of preparing such dosage forms are known, or will be apparent, to those skilled in this art; for example, see Remington: The Science and Practice of Pharmacy, 20th Edition (Philadelphia College of Pharmacy and Science, 2000). The composition to be administered will, in any event, contain a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, for treatment of a disease or condition of interest in accordance with the teachings of this invention. A pharmaceutical composition of the invention may be in the form of a solid or liquid. In one aspect, the carrier(s) are particulate, so that the compositions are, for example, in tablet or powder form. The carrier(s) may be liquid, with the compositions being, for example, an oral oil, injectable liquid or an aerosol, which is useful in, for example, inhalatory administration.

When intended for oral administration, the pharmaceutical composition is preferably in either solid or liquid form, where semi-solid, semi-liquid, suspension and gel 161 162 forms are included within the forms considered herein as either solid or liquid.

As a solid composition for oral administration, the pharmaceutical composition may be formulated into a powder, granule, compressed tablet, pill, capsule, chewing gum, wafer or the like form. Such a solid composition will typically contain one or more 5 inert diluents or edible carriers. In addition, one or more of the following may be present: binders such as carboxymethylcellulose, ethyl cellulose, microcrystalline cellulose, gum tragacanth or gelatin; excipients such as starch, lactose or dextrins, disintegrating agents such as alginic acid, sodium alginate, Primogel, corn starch and the like; lubricants such as magnesium stearate or Sterotex; glidants such as colloidal silicon dioxide; sweetening 10 agents such as sucrose or saccharin; a flavoring agent such as peppermint, methyl salicylate or orange flavoring; and a coloring agent.

When the pharmaceutical composition is in the form of a capsule, for example, a gelatin capsule, it may contain, in addition to materials of the above type, a liquid carrier such as polyethylene glycol or oil. 15 The pharmaceutical composition may be in the form of a liquid, for example, an elixir, syrup, solution, emulsion or suspension. The liquid may be for oral administration or for delivery by injection, as two examples. When intended for oral administration, preferred composition contain, in addition to the present compounds, one or more of a sweetening agent, preservatives, dye/colorant and flavor enhancer. In a composition 20 intended to be administered by injection, one or more of a surfactant, preservative, wetting agent, dispersing agent, suspending agent, buffer, stabilizer and isotonic agent may be included.

The liquid pharmaceutical compositions of the invention, whether they be solutions, suspensions or other like form, may include one or more of the following 25 adjuvants: sterile diluents such as water for injection, saline solution, preferably physiological saline, Ringer’s solution, isotonic sodium chloride, fixed oils such as synthetic mono or diglycerides which may serve as the solvent or suspending medium, polyethylene glycols, glycerin, propylene glycol or other solvents; antibacterial agents such as benzyl alcohol or methyl paraben; antioxidants such as ascorbic acid or sodium 30 bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic. Physiological saline is a preferred adjuvant. An injectable pharmaceutical composition is preferably sterile. 35 A liquid pharmaceutical composition of the invention intended for either 162 163 parenteral or oral administration should contain an amount of a compound of the invention such that a suitable dosage will be obtained. Typically, this amount is at least 0.01% of a compound of the invention in the composition. When intended for oral administration, this amount may be varied to be between 0.1 and about 70% of the weight of the composition. Preferred oral pharmaceutical compositions contain between about 4% and about 75% of the compound of the invention. Preferred pharmaceutical compositions and preparations according to the present invention are prepared so that a parenteral dosage unit contains between 0.01 to 10% by weight of the compound prior to dilution of the invention.

The pharmaceutical composition of the invention may be intended for topical administration, in which case the carrier may suitably comprise a solution, emulsion, ointment or gel base. The base, for example, may comprise one or more of the following: petrolatum, lanolin, polyethylene glycols, bee wax, mineral oil, diluents such as water and alcohol, and emulsifiers and stabilizers. Thickening agents may be present in a pharmaceutical composition for topical administration. If intended for transdermal administration, the composition may include a transdermal patch or iontophoresis device. Topical formulations may contain a concentration of the compound of the invention from about 0.1 to about 10% w/v (weight per unit volume).

The pharmaceutical composition of the invention may be intended for rectal administration, in the form, for example, of a suppository, which will melt in the rectum and release the drug. The composition for rectal administration may contain an oleaginous base as a suitable nonirritating excipient. Such bases include, without limitation, lanolin, cocoa butter and polyethylene glycol.

The pharmaceutical composition of the invention may include various materials, which modify the physical form of a solid or liquid dosage unit. For example, the composition may include materials that form a coating shell around the active ingredients. The materials that form the coating shell are typically inert, and may be selected from, for example, sugar, shellac, and other enteric coating agents.

Alternatively, the active ingredients may be encased in a gelatin capsule.

The pharmaceutical composition of the invention in solid or liquid form may include an agent that binds to the compound of the invention and thereby assists in the delivery of the compound. Suitable agents that may act in this capacity include a monoclonal or polyclonal antibody, a protein or a liposome.

The pharmaceutical composition of the invention may consist of dosage units that can be administered as an aerosol. The term aerosol is used to denote a variety of 163 164 systems ranging from those of colloidal nature to systems consisting of pressurized packages, Delivery may be by a liquefied or compressed gas or by a suitable pump system that dispenses the active ingredients. Aerosols of compounds of the invention may be delivered in single phase, bi-phasic, or tri-phasic systems in order to deliver the active ingredient(s). Delivery of the aerosol includes the necessary container, activators, valves, subcontainers, and the like, which together may form a kit. One of ordinary skill in the art, without undue experimentation may determine preferred aerosols.

The pharmaceutical compositions of the invention may be prepared by methodology well known in the pharmaceutical art. For example, a pharmaceutical composition intended to be administered by injection can be prepared by combining a compound of the invention with sterile, distilled water so as to form a solution. A surfactant may be added to facilitate the formation of a homogeneous solution or suspension. Surfactants are compounds that non-covalently interact with the compound of the invention so as to facilitate dissolution or homogeneous suspension of the compound in the aqueous delivery system.

The compounds of the invention, or their pharmaceutically acceptable salts, are administered in a therapeutically effective amount, which will vary depending upon a variety of factors including the activity of the specific compound employed; the metabolic stability and length of action of the compound; the age, body weight, general health, sex, and diet of the patient; the mode and time of administration; the rate of excretion; the drug combination; the severity of the particular disorder or condition; and the subject undergoing therapy. Generally, a therapeutically effective daily dose is (for a 70 kg mammal) from about 0.001 mg/kg (/.e., 0.70 mg) to about 100 mg/kg (/.e., 7.0 gm); preferaby a therapeutically effective dose is (for a 70 kg mammal) from about 0.01 mg/kg (i.e., 0.7 mg) to about 50 mg/kg (i.e., 3.5 gm); more preferably a therapeutically effective dose is (for a 70 kg mammal) from about 1 mg/kg (/.e., 70 mg) to about 25 mg/kg (i.e., 1.75 gm).

Compounds of the invention, or pharmaceutically acceptable salts thereof, may also be administered simultaneously with, prior to, or after administration of one or more other therapeutic agents. Such combination therapy includes administration of a single pharmaceutical dosage formulation which contains a compound of the invention and one or more additional active agents, as well as administration of the compound of the invention and each active agent in its own separate pharmaceutical dosage formulation. For example, a compound of the invention and the other active agent can be administered to the patient together in a single oral dosage composition such as a tablet 164 165 or capsule, or each agent administered in separate oral dosage formulations. Where separate dosage formulations are used, the compounds of the invention and one or more additional active agents can be administered at essentially the same time, i.e., concurrently, or at separately staggered times, i.e., sequentially; combination therapy is understood to include all these regimens.

PREPARATION OF THE COMPOUNDS OF THE INVENTION

The following Reaction Schemes illustrate methods to make compounds of formula (I), as isolated stereoisomers or mixtures thereof, or as pharmaceutically acceptable salts thereof. In particular, the following Reaction Scheme illustrates a method to make certain compounds of formula (I), i.e., the compounds of formula (la):

<img img-format="tif" img-content="drawing" file="IL207609AD000229.tif" id="idf0029" />

where n, m, Y, R1, R2, R3, R4 and R5 are as described above in the Embodiments section for compounds of formula (la), as isolated stereoisomers or mixtures thereof, or as pharmaceutically acceptable salts thereof. It is understood that in the following Reaction Schemes, combinations of substituents and/or variables of the depicted formulae are permissible only if such contributions result in stable compounds. It is also understood that other compounds of formula (I), particularly, compounds of formulae (la-1), (la-1 a), (la-1b), (la-1c), (la-1d), (!a-1e), (la-1f), (la-1g), (la-1 h), (la-1i), (la-1j), (la-1 k), (la-ll), (la-2), (la-2a), (la-2b), (la-2c), (la-2d), (la-2e), (la-2f), (la-2g), (la-2h), (la-2i), (la-2j), (la-2k) and (la-2l), and other compounds of the formula (I) not specifically disclosed herein, may be prepared by one skilled in the organic chemistry field by the methods disclosed herein (by utilizing the appropriately substituted starting materials and modifying the parameters of the synthesis as needed utilizing methods known to one skilled in the art) or by known methods.

Skilled artisans will recognize that in some instances, starting materials and intermediates in the preparation of the compounds of the invention may include functional groups that require protection during synthesis. The exact identity of any protecting group(s) used will depend upon the identity of the functional group being protected, and will be apparent to those of skill in the art. Guidance for selecting appropriate protecting groups, as well as synthetic strategies for their attachment and 165 166 removal, can be found, for example, in Greene &amp;amp; Wuts, Greene'sProtective Groups in

Organic Synthesis, 3d Edition, John Wiley &amp;amp; Sons, Inc., New York (1999) and the references cited therein (hereinafter "Greene &amp;amp; Wuts").

Thus, protecting group refers to a group of atoms that, when attached to a reactive functional group in a molecule, mask, reduce or prevent the reactivity of the functional group. Typically, a protecting group can be selectively removed as desired during the course of a synthesis. Examples of protecting groups can be found in Greene and Wuts, as mentioned above, and additionally, in Harrison etai., Compendium of Synthetic Organic Methods, Vols. 1-8, 1971-1996, John Wiley &amp;amp; Sons, NY. Representative amino protecting groups include, but are not limited to, formyl, acetyl, trifluoroacetyl, benzyl, benzyloxycarbonyl ("CBZ"), terf-butoxycarbonyl ("Boc"), trimethylsilyl ("TMS"), 2-trimethylsilyl-ethanesulfonyl ("TES"), trityl and substituted trityl groups, allyloxycarbonyl, 9-fluoreny!methyloxycarbonyl ("FMOC"), nitro-veratryloxycarbonyl ("NVOC") and the like. Representative hydroxyl protecting groups include, but are not limited to, those where the hydroxyl group is either acylated to form acetate and benzoate esters or alkylated to form benzyl and trityl ethers, as well as alkyl ethers, tetrahydropyranyl ethers, trialkylsilyl ethers (e.g., TMS orTIPPS groups) and allyl ethers.

It will also be appreciated by those skilled in the art, although such protected derivatives of compounds of this invention may not possess pharmacological activity as such, they may be administered to a mammal and thereafter metabolized in the body to form compounds of the invention which are pharmacologically active. Such derivatives may therefore be described as "prodrugs". All prodrugs of compounds of this invention are included within the scope of the invention.

In general, starting components may be obtained from sources such as Sigma Aldrich, Lancaster Synthesis, Inc., Maybridge, Matrix Scientific, TCI, and Fluorochem USA, etc. or synthesized according to sources known to those skilled in the art (see, for example, Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 5th edition (Wiley, December 2000)) or prepared as described herein. 1H NMR spectra are recorded in CDCI3l DMSO-cfe, CD3OD, or Acetone-cfe with trimethylsilane (TMS) as internal reference using Gemini 300 MHz instrument. Reagents and solvents were purchased from commercial sources and used without further purification. Flash column chromatography was conducted using silica gel (230-400 mesh) under a positive pressure of nitrogen. LCMS spectra for purity and mass were recorded using Waters LCMS instruments. Deionized water was used to dilute the reactions and wash the 166 167 products. Brine used was prepared by dissolving sodium chloride into deionized water to saturation point. A. Preparation of Compounds of Formula (Ia1)

Compounds of formula (Ia1) are compounds of formula (la), as described above 5 in the Embodiments, where R4 in the compounds of formula (la) has the following formula: R4a

<img img-format="tif" img-content="drawing" file="IL207609AD000230.tif" id="idf0030" />

Compounds of formula (Ia1) can be prepared as described below in Reaction Scheme 1 wherein n, m, Y. R1, R2 and R3 are as described above in the Embodiments 10 for compounds of formula (la); q is 0, 1 or 2; Y1 is =C(R6) (where R6 is as described above for R6 in the compounds of formula (I), as described above in the Summary of the Invention) or =N-; each Z is chloro or bromo; R4a is -N(Re)R7 (where R6 and R7 are each as described above in the compounds of formula (I), as described above in the Summary of the Invention); and each R4b, if present, is independently selected from the group 15 consisting of alkyl, halo and haloalkyl. Preferably, for compounds of formula (Ia1), q is 0. REACTION SCHEME 1

<img img-format="tif" img-content="drawing" file="IL207609AD000231.tif" id="idf0031" />

<img img-format="tif" img-content="drawing" file="IL207609AD000232.tif" id="idf0032" />

<img img-format="tif" img-content="drawing" file="IL207609AD000233.tif" id="idf0033" />

167 168

Compounds of formula (A), formula (B) and formula (D) are commercially available, or can be prepared according to methods known to one skilled in the art, or by the methods disclosed herein.

In general, compounds of formula (Ia1) can be prepared by methods known to 5 one skilled in the art and/or by the methods depicted above in Reaction Scheme 1 wherein a compound of formula (B) is coupled with a compound of formula (A) under suitable aromatic coupling conditions, such as, but not limited to, Suzuki coupling conditions known to one skilled in the art to provide a compound of formula (C). Compounds (C) are then treated with a compound of formula (D) under SNAr 10 (Substitution Nucleophilic Aromatic) conditions known to one skill in the art to provide a compound of formula (Ia1). A specific example of the preparation of a compound of the invention by the method disclosed above in Reaction Scheme 1 is the preparation of the compound (1), which is a compound of formula (Ia1), as shown below in Reaction Scheme 1 A.

15 REACTION SCHEME 1A

<img img-format="tif" img-content="drawing" file="IL207609AD000234.tif" id="idf0034" />

<img img-format="tif" img-content="drawing" file="IL207609AD000235.tif" id="idf0035" />

Details of the preparation of compound (1) are provided below in the appropriate Synthetic Preparation and/or Synthetic Example below.

Alternatively, compounds of formula (Ia1) (where n is 0) can be prepared, for 20 example, using a convergent synthesis as described below in Reaction Scheme 2. In particular, compounds of formula (la 1-1), which are compounds of formula (Ia1) where n 168 169 ι is 0 and R43 is -N(R6b)R7b (where R6b and R7b are independently selected from hydrogen or alkyl, or together with the common nitrogen to which they are attached, form an optionally substituted N-heterocyclyl), can be prepared as described below in Reaction Scheme 2 wherein m, Y, R1, and R2 are as described above in the Embodiments for 5 compounds of formula (la); q is 0, 1 or 2; Y1 is =C(R6) (where R6 is as described above for R6 in compounds of formula (la)) or =N-; Z is chloro or bromo; each R4b, if present, is independently selected from the group consisting of alkyl, halo and haloalkyl. Preferably, for compounds of formula (Ia1), q is 0, and R6b and R7b are independently selected from hydrogen or alkyl, or together with the common nitrogen to which they are attached, form 10 an optionally substituted N-heterocyclyl.

Compounds of formula (D), formula (E), formula (F), formula (H) and formula (M) are commercially available, or can be prepared according to methods known to one skilled in the art or by the methods disclosed herein. REACTION SCHEME 2

<img img-format="tif" img-content="drawing" file="IL207609AD000236.tif" id="idf0036" />

In general, compounds of formula (Ia1-1) can be prepared by methods known to one of ordinary skill in the art and/or by the methods depicted above in the Reaction Scheme 2 wherein, for example, α,β-unsaturated enamines of formula (G) are formed from the corresponding ketones of formula (E), for example, via Wittig-type homologation 20 using compound (F). Guanidines of formula (K) are prepared, for example, via conversion of anilines of formula (D) to the corresponding BOC-protected guanidines of formula (J), followed by deprotection. Guanidines of formula (K) and α,β-unsaturated enamines of formula (G) are then reacted to form the pyrimidine-2-amines of formula (L), 169

I 170 which can be further converted to the pyrimidine-2-amines of formula (Ia1 -1) via, for example, standard SNAr reaction conditions using, for example, an nucleophilic amine of formula (M). A specific example of the preparation of a compound of the invention by the 5 method disclosed above in Reaction Scheme 2 is the preparation of compound (1), as shown below in Reaction Scheme 2A.

REACTION SCHEME 2A

<img img-format="tif" img-content="drawing" file="IL207609AD000237.tif" id="idf0037" />

Details of the preparation of compound (1) by this method are provided below in 10 the appropriate Synthetic Preparations and Synthetic Examples.

Another specific example of the preparation of a compound of the invention by the method disclosed above in Reaction Scheme 2 is the preparation of compound (10), as shown below in Reaction Scheme 2B. 170 171

REACTION SCHEME 2B

<img img-format="tif" img-content="drawing" file="IL207609AD000238.tif" id="idf0038" />

<img img-format="tif" img-content="drawing" file="IL207609AD000239.tif" id="idf0039" />

In this example, nucleophilic amine (Mb) was added to pyridine (Ea) prior to formation of the enamine, pyrimidine, etc.. Consistent with the prior example, ketone 5 (Eb) is homologated to enamine (Gb). Enamine (Gb) is reacted with guanidine (Ka) to form pyrimidine-2-amine (10). Details of the preparation of compound (10) by this method are provided below in the appropriate Synthetic Preparations and Synthetic Examples.

The pharmaceutically acceptable salts of the compounds of the invention can be 10 formed by conventional means, such as by reacting the free base form of the product with one or more equivalents of the appropriate acid in a solvent or medium in which the salt is insoluble, or in a solvent such as water which is removed in vacuo or by freeze drying or by exchanging the anions of an existing salt for another anion on a suitable ion exchange resin. 15 The following specific Synthetic Preparations (for starting materials and intermediates) and Synthetic Examples (for compounds of the invention) are provided as a guide to assist in the practice of the invention, and are not intended as a limitation on the scope of the invention. The number following each compound below refers to its 171 172 number in Table 2 or Table 3, as discussed in more detail below. SYNTHETIC PREPARATION 1 Compounds of formula (Ca) 2-Chloro-4-(6-dimethylaminopyridin-3-yl)pyrimidine A flask containing 2,4-dichloropyrimidine (0.5 g, 3.35 mmol), [6-(dimethylamino)pyridin-3-yl]boronic acid (0.61 g, 3.67 mmol) and DME (10 mL) was purged with N2 for 10 min. Dichloro[1,1’-bis(diphenylphosphino)]ferrocene-palladium CH2CI2 adduct (0.37 g, 0.50 mmol) and triethylamine (0.85 g, 1.17 mL, 8.33 mmol) were added successively to the flask with continuous bubbling of N2 including 5 min. post addition of the reagents. The reaction mixture was stirred and heated at 90 °C for 5 h. Reaction progress was monitored by TLC (silica gel). The reaction mixture was concentrated and diluted with water, wherein a tan solid formed. The solid was filtered, dried and purified by silica gel column chromatography using 50% EtOAc/hexanes as eluent to provide 2-chloro-4-(6-dimethylaminopyridin-3-yl)pyrimidine as a white solid (0.56 g, 71%); 1H NMR (DMSO-d6): δ 8.91 (s, 1H), 8.60 (d, 1H, J = 5.3 Hz), 8.20 (dd, 1H, J = 2.3 and 9.1 Hz), 7.95 (d, 1H, J = 5.3 Hz), 6.74 (d, 1H, 7 = 9.1 Hz), 3.11 (s, 3H). LCMS: purity: 98%; MS (m/e): 235 (MH+). SYNTHETIC PREPARATION 2 Compounds of formula (Da) 3-Methyi-4-[(1 S,4S)-5-methyl-2, 5-diazabicyclo[2.2.1 ]heptan-2-yIjaniline A. (1S,4S)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane-2HBr (6 g, 21.89 mmol) (which can be prepared by similar methods as described in Braish, T.F et al., J. Org. Chem. (1990), Vol. 55, pp. 1684-1687), 2-fluoro-5-nitrotoluene (2.61 g, 16.82 mmol) and K2CO3 (10.57 g, 76.46 mmol) in 30 mL NMP were heated at 110 °C for 14 h while stirring. The reaction mixture was cooled to ambient temperature, poured onto ice-water and stirred until precipitate formation. The yellow solid formed was collected by filtration and washed with 15%EtOAc/hexanes to provide 2-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-5-nitrotoluene (3.4 g, 79%) in 98% purity; 1H NMR (DMSO-de): δ 7.88-7.55 (m, 2H), 6.69 (d, 1H, 7 = 8.8 Hz), 4.37 (s, 1H), 3.64 (dd, 1H, J = 2.0 and 9.9 Hz), 3.38-3.55 (m, 2H), 2.81 (d, 1H, J= 9.9 Hz), 2.65 (d, 1H, 7= 9.9 Hz), 2.33 (s, 3H), 2.23 (s, 3H), 1.87 (d, 1H, 7 = 9.3 Hz), 1.75 (d, 1H, 7= 9.3 Hz); LCMS: purity: 98%; MS (m/e): 248 (MH+). B. 2-[(1S,4S)-5-Methyl-2l5-diazabicyclo[2,2.1]hept-2-yl]-5-nitrotoluene (3,3 g) 172 173 was dissolved in EtOH (50 mL) and transferred to Parr hydrogenation flask. Catalyst, Pd/C (450 mg), was added and the mixture subjected to hydrogenation at 30 PSI for 2 h. The reaction mixture was filtered through Celite and the Celite filter cake washed with EtOH. Concentration of the combined filtrate provided 3-methyl-4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]ani(ine, as a tan solid (2.52 g, 86%). 1H NMR (DMSO-cfe): δ 6.58 (d, 1H, J = 8.8 Hz), 6.34 (s, 1H), 6.27 (d, 1H, J = 8.8 Hz), 4.46 (s, 2H), 3.61 (s, 1H), 3.24 (s, 1H), 3.16 (d, 1H, 9.3 Hz), 2.93 (dd, 1H, 1.8 and 9.3 Hz), 2.61 (qt, 2H, J = 9.3 Hz), 2.26 (s, 3H), 2.05 (s, 3H), 1.70 (d, 1H, J = 9.1 Hz), 1.63 (d, 1H, J =9.1 Hz). LCMS: purity: 97%; MS (m/e): 218 (MH+). C. Alternatively, a heterogeneous mixture of (1 S,4S)-2-methyl-2,5-diazabicyclo[2.2.1]heptane 2HBr salt (0.544 g, 2 mmol), 2-fluoro-5-nitrotoluene (0.310 g, 2 mmol) and DIPEA (0.387 g, 6 mmol) in NMP was refluxed for 2 days. The resulting residue was purified by column chromatography (silica gel, hexanes then 5-10% EtOAc in hexanes to afford 2-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-5-nitrotoluene, which was reduced by hydrogenation (H2l 10% Pd/C, MeOH, 40 PS!) to afford 3-methyl-4-[(1S,4S)-5-methyl-2, 5-diazabicyclo[2.2.1]heptan-2-yl]aniline; LCMS: purity: 91%; MS (m/e): 218 (MH+). D. Alternatively, (1S, 4S)-2-Methyl-2, 5-diazabicyc!o[2.2.1]heptane.2HBr (24.8 g, 90.5 mmol), 2-fluoro-5-nitrotoluene (12.0 g, 77.3 mmol) and K2CO3(43.7 g, 316.9 mmol) in 90 mL NMP were heated at 110 °C for 14 h by stirring. The reaction mixture was allowed to cool and quenched by pouring into water (500 mL). The contents were then stirred until precipitation was observed (3-4 h). The yellow solid formed was collected by filtration. The resulting filter cake washed with water (700 mL) and dried under vacuum suction. The filter cake was re-suspended in 10% EtOAc / hexanes (100 mL) as a slurry and then filtered to provide the desired material 2-((1 S, 4S)-5-methyl-2,5-diazabicyclo(2.2.1]hept-2-yl]-5-nitrotoluene (14.2 g, 74% based on nitrotoluene; 63% based on diazabicycloheptane) after drying; 1H NMR (DMSO-cfe): δ 7.88-7.55 (m, 2H), 6.69 (d, 1H, J = 8.8 Hz), 4.37 (s, 1H), 3.64 (dd, 1H, J = 2.0 and 9.9 Hz), 3.38-3.55 (m, 2H), 2.81 (d, 1H, J = 9.9 Hz), 2.65 (d, 1H, J = 9.9 Hz), 2.33 (s, 3H), 2.23 (s, 3H), 1.87 (d, 1H, J = 9.3 Hz), 1.75 (d, 1H, J = 9.3 Hz). LCMS: purity: 98%; MS (m/e): 248 (MH+). E. 2-((1 S,4S)-5-Methyl-2, 5-diazabicyclo[2.2.1]hept-2-yl]-5-nitrotoluene (14.2 g), as prepared above in Paragraph D, was dissolved in EtOH (50 mL), transferred to a Parr hydrogenation flask. Pd/C (1.5 g) was introduced to above flask and subjected to hydrogenation at 30 psi for 2 h. The reaction mixture was filtered through Celite and the filter cake was washed further with EtOH (300 mL). Concentration of the filtrate provided 173 174 3-Methyl-4-[(1 S, 4S)-5-methyl-2, 5-diazabicyclo[2.2.1]hept-2-yl]aniline as a white-tan solid (11.7 g, 86%); 1H NMR (DMSO-cfe): δ 6.58 (d, 1H, J = 8.8 Hz), 6.34 (s, 1H), 6.27 (d, 1H, J = 8.8 Hz), 4.46 (s, 2H), 3.61 (s, 1H), 3.24 (s, 1H), 3.16 (d, 1H,7 = 9.3 Hz), 2.93 (dd, 1H, 7= 1.8 and 9.3 Hz), 2.61 (qt, 2H, 7 = 9.3 Hz), 2.26 (s, 3H), 2.05 (s, 3H), 1.70 (d, 5 1H, 7 = 9.1 Hz), 1.63 (d, 1H, 7 = 9.1 Hz). LCMS: purity: 97%; MS (m/e): 218 (MH+). SYNTHETIC PREPARATION 3 Compounds of formula (D) 4-(1,4-Diazabicyclo[3.2.2.]nonan-4-yl)-3-methylaniline A. A mixture of 2-fluoro-5-nitrotoluene (1.08 g, 6.98 mmol), 1,4- 10 diazabicyclo[3.2.2]nonane (0.8 g, 6.34 mmol) and K2CO3 (2.2 g, 15.86 mmol) in 8 mL of DMF was stirred at 100 °C for 16 h. After cooling to ambient temperature, water (40 mL) was slowly added to the mixture. The resulting (yellow) solid was filtered and washed three times with water. Thin layer chromatography showed trace amount of starting aryl fluoride. The solid 4-(2-methyl-4-nitrophenyS)-1,4-diazabicycio[3.2.2]nonane 15 was suspended in 25 mL of Et2O, sonicated for 10 min, collected by filtration and washed with Et2O; 950 mg; Purity (LC-MS): &gt;97%; MS (m/e): 262.4 (MH+). B. 4-(2-Methyl-4-nitrophenyl)-1,4-diazabicyclo[3,2.2]nonane (950m) was dissolved in 30 mL of MeOH. Catalyst, 10% Pd-C (300 mg), was then added, and the mixture was hydrogenated at the atmosphere of H2 (50 psi) for 1 h. The reaction mixture 20 was filtered through Celite and washed with MeOH. 4-(1,4-Diazabicyclo[3.2.2.]nonan-4-yl)-3-methylaniline was obtained as a dark oil in quantitative yield; Purity (LC-MS): 97.48%; MS (m/e): 231.1 (MH+). SYNTHETIC PREPARATION 4 Compounds of formula (Eb) 25 1 -[6-(Morpho I i n-4-y I )py ri d i n-3-y I )]ethan one 1-(6-chloro-3-pyridinyl)ethanone (20 g, 128.55 mmol) and morpholine (43 mL, 43 g, 493 mmol) in ethanol (100 mL) were heated to reflux at 95 °C. Upon consumption of 1-(6-chloro-3-pyridinyl)ethanone (18 h), the reaction mixture was cooled and concentrated to dryness. An ice-cold solution of water (65 mL) was transferred to the 30 . above material, then sonicated for 10 min and stirred at 0 °C for a period of 2 h. The solid formed was collected by filtration and suction dried. Further workup of the solid by reslurrying in ice-cold solution of water (250 mL) and filtration of the slurry provided 18.8 g (70%) of 1-[6-(morphoiin-4-yl)pyridin-3-yl)]ethanone as off-white tan solid after vacuum 174 175 drying; 1H NMR (DMSO-d6): δ 8.71 (d, 1H, J = 2.4 Hz), 8.00 (dd, 1H, J= 1.4 and 9.0 Hz), 6.86 (d, 1H, J= 9.0 Hz), 2.44 (s, 3H). LCMS: purity: 96%; MS (m/e): 207 (MH+). SYNTHETIC PREPARATION 5 Compounds of formula (Ga) 3-(3-(Dimethylamino)prop-2-en-1-onyl)-6-chloropyridine A homogeneous mixture of 3-acetyl-6-chloropyridine (5 mL) (which can be prepared in a similar manner by the methods disclosed in Lee, C-H. et ai., J. Med.

Chem. (2001), Vol. 44, pp. 2133-2138) in N,A/-dimethylform amide dimethylacetal (15 mL) was refluxed for 4 h. After cooling the reaction mixture to ambient temperature, it was diluted with hexanes (100 mL), sonicated for 30 seconds and the solid formed was isolated by filtration. The resulting solid was then washed with hexanes (3 x 25 mL), dried and analyzed to afford 3-(3-(dimethylamino)prop-2~en-1-onyl)-6-chloropyridine; LCMS: purity: 92%; MS (m/e): 212 (MH+). SYNTHETIC PREPARATION 6 Compounds of formula (Gb) 3-[3-(Dimethylamino-2-propen-1-one)-6-(morphoiin-4-yl)pyridine 1-[6-(morpholin-4-yl)pyridin-3-yl)]ethanone (18 g, 87.3 mmol) in Λ/,/V-dimethylformamide dimethylacetal (100 mL) was heated to reflux (110 °C) till complete consumption of 1-[6-(morpholin-4-yl)pyridin-3-yl)]ethanone as determined by silica gel TLC and LC/MS. After 45 h, the heterogeneous reaction mixture was cooled to ambient temperature and the crude product collected by filtration. The filter cake was washed with Et2O (75 mL) and dried under vacuum to provide 18.0 g (78%) of 3-(3-(dimethylamino-2-propen-1-one)-6~(morpholin-4-yl)pyridine; 1H NMR (DMSO-d6): 6 8.69 (d, 1H, J = 2.4 Hz), 8.00 (dd, 1H, J = 2.4 and 9.0 Hz), 7.62 (d, 1H, J =12.3 Hz), 6.80 (d, 1H, 9.0 Hz), 5.76 (d, 1H, J= 12.3 Hz), 3.68-3.65 (m 4H), 3.61-3.59 (m, 4H), 3.30 (s, 3H), 2.87 (s, 3H). LCMS: purity: 99%; MS (m/e): 262 (MH+) SYNTHETIC PREPARATION 7 Compounds of formula (Ja) [3-methyl-4-((1$,4$)-2-methyl-2,5-diazabicyclo[2.2.1]heptan-5-yl)phenyl][A/,A/-bis(terf- butoxycarbonyl)]guanidine A. Compound (Da), 3-methyl-4-[(1$,4S)-5-methy!-2,5-diazabicyclo[2.2.1]heptan-2-yl]aniline, (0.105 g, 0.6 mmol) and 1-(ferf- 175 176 butoxycarbonylamino(ferf-butoxycarbonylimino)methyl)pyrazole (Η) (0.186 g, 0.6 mmol) were combined in DMF (2 mL) and stirred at ambient temperature for 3 days. The reaction was monitored by LCMS. The homogenous reaction mixture was then diluted with water (20 mL), the solid precipitate formed was isolated by filtration, and purified by column chromatography (silica gel, CH2CI2 then 2-5% MeOH in CH2CI2) to give [3-methyl-4-((1$,4S)-2-methyl-2,5-diazabicyclo[2.2.1]heptan-5-yl)phenyl][N,/V-bis(fert-butoxycarbonyl)]guanidine; LCMS: purity: 99%; MS (m/e): 460 (MH+). B. On a larger scale, 3-methyl-4-[(1 S,4S)-5-methyl-2,5-diazabicyc!o[2.2.1]hept-2-yl]aniline(10.0 g, 45.8 mmol) and 1-(iert-butoxycarbonylamino(terf-butoxycarbonylimino)methyl)pyrazole (15.0 g, 48.2 mmol) were combined in DMF (25 mL) and stirred at ambient temperature. The progress of homogenous reaction was monitored by LC/MS. After 36 h, the reaction mixture was added slowly to water (300 mL) in a beaker with vigorous stirring, whereupon a precipitate formed. The reaction flask was rinsed with DMF (2 X 5 mL) and transferred to the beaker. Suction filtration ofthe suspension, further washing ofthe resulting filter cake with water (200 mL) and air drying under suction provided 20.5 g (97%) of [3-methyl-4-((1S,4S)-2-methyl-2,5-diazabicyclo[2.2.1]heptan-5-yl)phenylj[N,N-bis(fert-butoxycarbonyl)lguanidine (Ja) as a off-white purple solid; LCMS: purity: 96%; MS (m/e): 449 (MH*). SYNTHETIC PREPARATION 8 Compounds of formula (Ka) [3-methyl-4-((1S,4$)-2-methyl-2,5-diazabicyclo[2.2.1]heptan-5-yl)phenyl]guanidine A. A solution of [3-methyl-4-((1S,4$)-2-methyt-2,5-diazabicyclo[2.2.1]heptan- 5-yl)phenyl][A/,A/-bis(terf-butoxycarbonyl)]guanidine (0.100 g) in CH2CI2 (20 mL) with TFA (5 mL) was stirred at ambient temperature for 4 h. The reaction progress was monitored by TLC (silica gel). The resulting mixture was concentrated and the lyophilized to afford [3-methyl-4-((1 S,4S)-2-methyl-2,5-diazabicyclo[2.2.1 ]heptan-5-yl)phenyljguanidine, as a TFA salt; LCMS: purity: 89%; MS (m/e): 260 (MH+). B. Alternatively, TFA (80 mL) was added to a stirred solution of [3-methyl-4-((1S,4$)-2-methyl-2,5-diazabicyclo[2,2.1]heptan-5-yl)phenyl][/V,A/-bis(tert-butoxycarbonyl)]guanidine (20.2 g) in CH2CI2 (80 mL) at 0 °C over a period of 30 min. The ice-bath was removed after 1 h and the reaction contents allowed to stir. Progress of the reaction mixture was monitored by LC/MS. The reaction mixture was concentrated after complete conversion of the starting material to [3-methyl-4«((1S,4S)-2-methyl-2,5- 176 177 diazabicycfo[2.2.1 ]heptan-5-yl)phenyl]guanidine, dried overnight under high vacuum and used in the next step without further purification. LCMS: purity: 96%; Crude weight: 45.4 g, back calculation provided approximately 34 g of total amount of TFA present in the crude. 5 SYNTHETIC EXAMPLE 1 4-(6-(/V,N-dimethylamino)pyridin-3-yl)-N“(3-methyl-4-((1$,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine

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A. 2-Chloro-4-(6-dimethylaminopyridin-3-yl)pyrimidine (35 mg, 0.15 mmol) 10 and 3-methy 1-4-((1 S,4S)-5-methyl-2, 5-diazabicyclo[2.2.1]heptan-2-yl]phenylamine (55 mg, 0.25 mmol) in 1.5 mL 2-propanol with TFA (4 drops) were heated at 100 °C for 12 h in a sealed tube. Reaction progress was monitored by LC/MS. Upon completion, the reaction mixture was concentrated and purified by preparative HPLC. The pure concentrate, obtained after purification, was exposed to aq. K2CO3 solution to neutralize 15 any acid remaining. The solid formed upon exposure to aq. K2CO3 solution was collected by filtration, washed with water and dried to provide 4-(6-(Λ/,Λ/-dimethylamino)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #1, as an off-white solid (35 mg, 56%). 1H NMR (DMSO-d6): δ 9.13 (s, 1H), 8.81 (s, 1H), 8.31 (d, 1H, J= 5.3 20 Hz), 8.20 (dd, 1H, J = 2.3 and 8.8 Hz), 7.49 (dd, 1H, J = 2.3 and 8.8 Hz), 7.43 (s, 1H), 7.17 (d, 1H, J = 5.3 Hz), 6.74 (d, 2H, J = 8.8 Hz), 3.88 (s, 1H), 3.20 (app qt, 2H, J = 9.0 Hz), 3.09 (s, 6H), 2.71 (appqt, 2H, J= 9 .0 Hz), 2.27 (s, 3H), 2.19 (s, 3H), 1.77 (d, 1H, J = 9.0 Hz), 1.69 (d, 1H, J = 9.0 Hz); LCMS: purity: 98%; MS (m/e): 416 (MH+). B. Alternatively, a heterogeneous mixture of 3-(3-(dimethylamino)prop-2-en- 25 1-onyl)-6-chloropyridine (0.063 g, 0.75 mmol) and [3-methyl-4-((1 S,4S)-2-methyl-2,5- diazabicyclo[2.2.1]heptan-5-yl)phenyl]guanidine TFA salt ( 0.110 g, 0.75 mmol) with K2CO3( 0.051 g, 2.25 mmol) in isopropanol (1 mL) was shaken in a sealed tube at 100 °C in for 24h. The formation of 4-(6-(chloro)pyridin-3-yl)-N-(3-methyl-4-((1S,45)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine was confirmed by 177 178 LCMS. To this reaction vial 40% of aqueous solution of Me2NH.HCI solution (1 mL) was added and then heated in a sealed tube for 3 h at 100 °C. The resulting reaction mixture was purified by column chromatography (silica gel; CH2CI2 then 1% 2N NH3/MeOH in CH2CI2) to afford 4-(6-(N,N-dimethylamino)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl- 5 2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pynmidin-2-amine, compound #1; LCMS: purity: 99%; MS (m/e): 416 (MH+). SYNTHETIC EXAMPLE 2 4-(6-( NlA/-dimethylamino)pyridin-3-yl)-5-methyl-A/-(3-methyl-4-((1$,4S)-5-methy[-2,5-10 diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine

Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(6-(Λ/,Λ/- 15 dimethylamino)pyridin-3-yl)-5-methyl-/V-(3-methyl-4-((1 $,4S)-5-methyl-2,5- diazabicyc!o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #2, was obtained; AH NMR (DMSO-de): δ 9.04 (s, 1H), 8.48 (d, 1H, J= 1.8 Hz), 8.22 (s, 1H), 7.89 (dd, 1H, J = 2.0 and 8.8 Hz), 7.45 (app d, 1H, J = 8.8 Hz),7.40 (s, 1H), 6.71 (t, 2H, J = 8.8 Hz), 3.84 (s, 1H), 3.18 (d, 1H, J= 9.0 Hz), 3.11 (d, 1H, J = 9.0 Hz), 3.08 (s, 6H), 2.72 (d, 1H, J= 9 20 .0 Hz), 2.64 (d, 1H, J = 9.0 Hz), 2.25 (s, 3H), 2.23 (s, 3H), 2.16 (s, 3H), 1.75 (d, 1H, J = 9.0 Hz), 1.67 (d, 1H, J = 9.0 Hz); LCMS: purity: 99%; MS (m/e): 430 (MH+). 178 179 SYNTHETIC EXAMPLE 3 4-(6-(N,N-dimethylamino)pyridin-3-yi)-5-trifluoromethyl-A/-(3-methyl-4-((1S,4S)-5-methyl- 2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine

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5 Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(6-(/V,N- dimethylamino)pyridin-3-yl)-5-trifluoromethyl-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #3, was obtained; 10 Ή NMR (DMSO-cfe): δ 9.91 (s, 1H), 8.68 (s, 1H), 8.34 (s, 1H), 7.74 (app d, 1H,4=8.8 Hz), 7.40-7.37 (m, 2H), 6.73 (d, 1H, 4 = 8.8 Hz), 6.71 (d, 1H, 4 = 8.8 Hz), 3.90 (s, 1H), 3.18 (s, 2H), 3.08 (s, 6H), 2.72 (d, 1H, 4 = 9 .0 Hz), 2.65 (d, 1H, 4 = 9.0 Hz), 2.25 (s, 3H), 2.17 (s, 3H), 1.77 (d, 1H, 4 = 9.0 Hz), 1.67 (d, 1H, 4 = 9.0 Hz); LCMS: purity: 99%; MS (m/e): 484 (MH+). 15 SYNTHETIC EXAMPLE 4 4-(6-(/V,/V-dimethylamino)pyridin-3-yl)-5-fluoro-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine

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Following substantially one of the procedures as described in SYNTHETIC 20 EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(6-(A/,/\/-dimethylamino)pyridin-3-yl)-5-fluoro-/V-(3-methyl-4-((1S,4$)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #4, was obtained; 179 ) 180 1Η NMR (DMSO-d6): δ 9.23 (s, 1Η), 8.80 (s, 1 Η), 8.40 (d, 1 Η, 4 = 4.1 Hz), 8.15 (app d, 1H, 4 = 9.1 Hz), 7.43-7.38 (m, 2H), 6.79 (d, 1H, 4 = 9.1 Hz), 6.73 (d, 1H, 4 = 8.8 Hz), 3.87 (s, 1H), 3.21 (d, 1H, 4= 9.0 Hz), 3.17 (d, 1H, 4= 9.0 Hz), 3.10 (s, 6H), 2.72 (d, 1H, J = 9.0 Hz), 2.66 (d, 1H, J = 9.0 Hz), 2.26 9s, 3H), 2.18 (s, 3H), 1.76 (d, 1H, J = 9.0 Hz), 5 1.67 (d, 1H, J = 9.0 Hz); LCMS: purity: 99%; MS (m/e): 434 (MH+)· SYNTHETIC EXAMPLE 5 4-(6-(N,A/-dimethyiamino)pyridin-3-yl)-5-fiuoro-W-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine

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10 Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-criticai variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(Q-(N,N- dimethylamino)pyridin-3-yl)-5-fluoro-/\/-(3-fluoro-4-((1S,4S)-5-methyl-2l5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #5, was obtained; 15 1H NMR (DMSO-ck): δ 9.45 (s, 1H), 8.80 (s, 1H), 8.44 (d, 1H, J = 1.4 and 9.0 hz), 7.58 (dd, 1H, J = 9.1 and 16 Hz), 7.29 (d, 1H, 4 = 8.8 hz), 6.80 (d, 1H, 4 = 9.1 H), 6.68 (app t, 1H, 4 = 9.3 Hz), 4.15 (s, 1H), 3,39 (d, 1H, 4= 9.0 Hz), 3.16 (d, 1H, 4 = 9.0 Hz), 3.11 (s, 6H), 2.72 (d, 1H, 4 = 9.1 Hz), 2.59 (d, 1H, 4 = 9.0 Hz), 2.23 (s, 3H), 1.80 (d, 1H,4 = 9.0 Hz), 1.69 (d, 1H, 4 = 9.0 Hz); LCMS: purity: 98%; MS (m/e): 438 (MH+). 20 SYNTHETIC EXAMPLE 6 4-(6-(N,A/-dimethylamino)pyridin-3-yl)-5-methyl-A/-(3-fluoro-4-((1S,4S)-5-rriethyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine

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180 181

Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(6-(Λ/,Ν- dimethylamino)pyridin-3-yl)-5-methyl-/\/-(3-fluoro-4-((1S,4$)-5-methyl-2,5- 5 diazabicyclo[2.2.1]heptan-2«yl)phenyl)pyrimidin-2-amine, compound #6, was obtained; 1H NMR (DMSO-de): δ 9.27 (s, 1H), 8.49 (d, 1H, J = 2.3 Hz), 8.26 (s, H), 7.88 (d, 1H, J = 2.3 and 8.8 Hz), 7.66 (d, 1H, J = 2.3 and 16.8 Hz), 7.31 (d, 1H, J = 8.8 Hz), 6.73 (d, 1H, J = 8.8 Hz), 6.65 (app t, 1H, J = 10.0 Hz), 4.13 (s, 1H), 3.37 (app d, 1H, J = 9.0 Hz), 3.15 (dd, 1H, J = 2.6 and 9.0 Hz), 3.08 (s, 6H), 2.70 (d, 1H, J = 9.0 Hz), 2.59 (d, 1H, J = 9.0 10 Hz), 2.24 (s, 3H), 2.23 (s, 3H), 1.79 (d, 1H, J = 9.0 Hz), 1.69 (d, 1H, J = 9.0 Hz); LCMS: purity: 98%; MS (m/e): 434 (MH+). SYNTHETIC EXAMPLE 7 4-(6-(/7, /V-dimethy lam ino)pyridin-3-yl)-/V-(3-fluoro-4-(( 1S, 4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine

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Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(6-(/7, Λ/- dimethylamino)pyridin-3-yl)-A/-(3-fluoro-4-((1S,4S)~5-methyl-2,5-20 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #7, was obtained; Ή NMR (DMSO-&lt;/6): δ 9.36 &lt;s, 1H), 8.88 (s, 1H), 8.35 (d, 1H. J- 5.3 Hz), 8.19 (dd, 1H, J = 2.3 and 8.8 Hz), 7.64 (d, 1H, J = 2.3 and 16.8 Hz), 7.35 (d, 1H, J = 8.2 Hz), 7.22(d, 1H, J = 5.3 Hz), 6.75 (d, 1H, J = 9.1 Hz), 6.65 (app t, 1H, J =9.0 Hz), 4.16 (s, 1H), 3.39 (app d, 1H, J = 9.0 Hz), 3.18 (app d, 1H, J=9.0 Hz), 3.10 (s, 6H), 2.72 (d, 1H, J = 9.1 Hz), 25 2.59 (d, 1H, J= 9.0 Hz), 2.23 (s, 3H), 1.79 (d, 1H, J = 9.0 Hz), 1.69 (d, 1H, J = 9.0 Hz); LCMS: purity: 98%; MS (m/e): 420 (MH*). 181 182 SYNTHETIC EXAMPLE 8 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5- methyl-2,5-diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine

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5 Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(4-methyl-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #8, was obtained; 10 1H NMR (DMSO-ds): δ 9.13 (s, 1H), 8.49 (app s, 1H), 8.31 (d, 1H, J =5.3 Hz), 7.70 (app s, 1H), 7.45 (app s, 2H), 7.16 (d, 1H, J = 5.3 Hz), 6.73 (d, 1H, J=8.4 Hz), 4.22 (m, 2H), 3.88 (s, 1H), 3.51 (s, 2H), 3.19 (d, 1H, J =9.5 Hz), 3.14 (app d, 1H, J = 9.5 Hz), 3.10 (s, 6H), 2.72 (d, 1H, J = 9.5 Hz), 2.65 (d, 1H, J = 9.5 Hz), 2.26 (s, 3H), 2.18 (s, 3H), 1.76 (d, 1H, J = 9.0 Hz), 1.69 (d, 1H, J = 9.0 Hz); LCMS: purity: 98%; MS (m/e): 444 (MH+). 15 SYNTHETIC EXAMPLE 9 4-(4-rnethyl-3,4-dihydro-2H-pyrido[3,2-bK1,4loxazin-7-yl)-/V-(3-fluoro-4-((1S,4$)-5- methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine

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Following substantially one of the procedures as described in SYNTHETIC 20 EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-fluoro-4-((1S,4S)-5-methy1-2,5-diazabicyclo[2.2.1]heptan-2~yl)phenyl)pyrimidin-2-amine, compound #9, was obtained; 182 183 Ή NMR (DMSO-c/6): δ 9.34 (s, 1 Η), 8.51 (d, 1H, J = 0.9 Hz), 8.35 (d, 1H, J = 5.3 Hz), 7.67 (d, 1H, J = 17.4 Hz), 7.60 (d. 1H, J = 0.9 Hz), 7.31 (d, 1H, J = 8.2 Hz), 7.20 (d, 1H, J = 5.3 Hz), 6.68 (appt, 1H, 7 = 9.5 Hz), 4.23-4.21 (m, 2H), 4.16 (s, 1H), 3.53-3.50 (m, 2H), 3.39 (d, 1H, J = 9.6 Hz), 3.17 (d, 1H, J = 9.6 Hz), 3.11 (s, 3H), 2.72 (d, 1H, 7 = 9.6 5 Hz), 2.59 (d, 1H, 7 = 9.6 Hz), 2.23 (s, 3H), 1.77 (d, 1H,7 = 9.4 Hz), 1.69 (d, 1H, 7 = 9.4 Hz); LCMS: purity: 98%; MS (m/e): 448 (MH+). SYNTHETIC EXAMPLE 10 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine

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A. Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- 15 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #10, was obtained; 1H NMR (DMSO-d6): δ 9.19 (s, 1H), 8.91(d, 1H, 7= 0.9 Hz), 8.35 (d, 1H, J= 5.3 Hz), 8.26 (d, 1H, J = 9.1 Hz), 7.48-7.44 (m, 2H), 7.20 (d, 1H, 7=5.3 Hz), 6.95 (d, 1H, 7=9.1 Hz), 3.66-3.63 (m, 4H), 3.55-3.53 (m, 4H), 3.19 (d, 1H, 7 = 8.8 Hz), 3.17 (d, 1H, 7 = 8.8 Hz), 2.70 (d, 1H, 7=9.1 Hz), 2.68 (d, 1H, 7 = 9.1 Hz), 2.27 (s, 3H), 2.18 (s, 3H), 1.77 (d, 20 1H, 7= 9.1 Hz), 1.69 (d, 1H, 7 = 9.1 Hz); LCMS: purity: 98%; MS (m/e): 459 (MH+). B. Alternatively, [3-methyl-4-((1$,4S)-2-methyl-2,5-diazabicyclo[2.2.1]heptan-5-yl)phenyl]guanidine TFA salt (45.4 g) was dissolved in 2-propanol (200 mL) and basified with 40 g of solid K2CO3 in portions. The pH was measured by diluting the respective aliquots with water drawn upon base addition [20g 25 (pH 5), 25 g (pH 7), 33 g (pH 9) and 40 g (pH 10)]. 3-[3-(Dimethylamino-2-propen-1-one)-6-(morpholin-4-yl)pyridine (10.5 g, 40.1 mmol) and additional 2-propanol (100 mL) were transferred to the above off-white basified guanidine heterogeneous mixture and heated to reflux at 120 °C. Progress of the reaction was monitored by LC/MS. Analysis 183 184 of the reaction after 96 h provided 23%, 6% and 67% of the guanidine, the enamine and the desired product, respectively. The resulting pale yellow heterogeneous mixture was cooled to ambient temperature and diluted with water (200 mL). The pale yellow solid formed upon stirring was filtered to provide 10.2 g of crude product. The collected solid 5 was suspended in water and filtered to provide 8.8 g (47%) of 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(( 1 S,4$)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine as a pale yellow powder upon drying, compound #10,1H NMR (DMSO-de): δ 9.19 (s, 1H), 8.91 (d, 1H, J = 0.9 Hz), 8.35 (d, 1H, J= 5.3 Hz), 8.26 (d, 1H,7 = 9.1 Hz), 7.48-7.44 (m, 2H), 7.20 (d, 1H,7=5.3 Hz), 6.95 (d, 1H,7 = 9.1 Hz), 10 3.66-3.63 (m, 4H), 3.55-3.53 (m, 4H), 3.19 (d, 1H, 7 = 8.8 Hz), 3.17 (d, 1H, 7 = 8.8 Hz), 2.70 (d, 1H, 7= 9.1 Hz), 2.68 (d, 1H, 7 = 9.1 Hz), 2.27 (s, 3H), 2.18 (s, 3H), 1.77 (d, 1H, 7 = 9.1 Hz), 1.69 (d, 1H, 7 = 9.1 Hz); LCMS: purity: 98%; MS (m/e): 458 (MH+). SYNTHETIC EXAMPLE 11 4-(6-(morpholin-4-yi)pyridin-3-yl)-N~(3-fluoro-4-((1$,4$)-5-methyl-2,5- 15 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine

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Following substantially one of the procedures as described in SYNTHETIC EXAMPLE 1 and making non-critical variations in the experimental parameters and using the appropriately substituted starting materials and reagents, 4-(6-(morpholin-4- 20 yl)pyridin-3-yl)-N-(3-fluoro-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2- yl)phenyl)pyrimidin-2-amine, compound #11, was obtained; 1H NMR (DMSO-d6): δ 9.40 (s, 1H), 8.91 (s, 1H), 8.38 (d, 1H, 7 = 5.3 Hz), 8.24 (d, 1H, 7 = 8.8 Hz), 7.67 (d, 1H, 7 = 16.4 Hz), 7.34 (d, 1H, 7 = 8.2 Hz), 7.25 (d, 1H, 7 = 5.3 Hz), 6.96 (d, 1H, 7=9.1 Hz), 6.68 (appt, 1H, 7= 9.9 Hz), 4.16 (s, 1H), 3.69-3.67 (m, 4H), 3.58-3.57 (m, 4H), 3.41 (d, 1H, 7 25 = 9.1 Hz), 3.17 (d, 1H, 7= 9.1 Hz), 2.72 (d, 1H, 7= 9.1 Hz), 2.59 (d, 1H, 7= 9.1 Hz), 2.23 (s, 3H), 1.79 (d, 1H, 7 = 8.8 Hz), 1.69 (d, 1H, 7 = 8.8 Hz); LCMS: purity: 99%; MS (m/e): 462 (MH+). 184 185 SYNTHETIC EXAMPLE 12

In a similar manner as described above utilizing the appropriately substituted starting materials and reagents, the following compounds of formula (la) were prepared: 4-(4-(/7,/V-dimethylamino)phenyl)-N-(3-methyl-4-((1S,4$)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #14, 1H NMR (DMSO-de): δ 9.09 (s, 1H), 8.28 (d, 1H, J = 5.4 Hz), 8.00 (d, 2H, J = 8.4 Hz), 7.48 (bs, 2H), 7.13 (d, 1H, J= 5.4 Hz), 6.78 (d, 2H, J = 8.7 Hz), 6.73 (d, 1H, 7 = 9.6 Hz), 3.87 (s, 1H), 3.17 (m, 2H), 2.98 (s, 6H), 2.69 (m, 2H), 2.26 (s, 3H), 2.19 (s, 3H), 1.76 (d, 1H, J = 9.3 Hz), 1.68 (d, 1H, J = 9.3 Hz); LCMS: purity: 99%; MS (m/e): 415 (MH+); 4-(4-( /Vl/V-dimethylamino)phenyl)-A/-(3-fluoro-4-((1Sl4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #15,1H NMR (DMSO-d6); δ 9.33 (s, 1H), 8.32 (d, 1H, J = 5.1 Hz), 7.99 (d, 2H, J = 9.0 Hz), 7.72 (d, 1H, J= 16.5 Hz), 7.36 (d, 1H, J= 8.7 Hz), 7.18 (d, 1H, J= 5.1 Hz), 6.74 (m, 3H), 4.21 (s, 1H), 3.47 (m, 2H), 3.21 (m, 1H), 2.99 (s, 6H), 2.80 (bs, 2H), 2.34 (s, 3H), 1.87 (d, 1H, J = 8.7 Hz), 1.77 (d, 1H, J = 8.7 Hz); LCMS: purity: 99%; MS (m/e); 419 (MH+); 4-(6-(4-acetylpiperazin-1-yl)pyridin-3-yl)-N-(3“fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #16,1H NMR (DMSO-d6): δ 9.40 (s, 1H), 8.91 (s, 1H), 8.37 (d, 1H, 7=5.4 Hz), 8.24 (d, 1H, 7 = 8.7 Hz), 7.66 (d, 1H, 7 = 16.2 Hz), 7.34 (d, 1H, 7 = 9.3 Hz), 7.25 (d, 1H, 7 = 5.1 Hz), 6.97 (d, 1H, 7 = 9.0 Hz), 6.68 (t, 1H, 7 = 9.6 Hz, 7 = 9.8 Hz), 4.16(s, 1H), 3.59 (m, 8H), 3.40 (m, 1H), 3.16 (m, 1H), 2.72 (d, 1H, 7 = 9.6 Hz), 2.58 (d, 1H, 7 = 9.6 Hz), 2.23 (s, 3H), 2.03 (s, 3H), 1.79 (d, 1H, J = 9.3 Hz), 1.69 (d, 1H, 7 = 9.3 Hz); LCMS: purity: 99%; MS (m/e): 503 (MH+); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/-/-pyrido[3,2-6][1,4]oxazin-7-yl)-/V-(3-fluoro-4- ((1Sl4S)-5-methyl-2l5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #19, 1H NMR (CD3OD, 300 MHz) 8.68 (m, 1H), 8.41 (m, 2H), 7.99 (m, 1H), 7.68 (m, 1H), 7.25 (m, 2H), 6.80 (m, 1H), 4.57 (s, 1H), 4.27 (s, 1H), 3.80 (m, 2H), 4.46 (m, 1H), 3.24 (s, 1H), 2.93 (s, 3H), 2.66 (m, 3H), 2.30 (m, 2H), 1.55 (s, 6H); MS (ES) 476.19 (M+H); 4-(2l2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3l2-b][1,4)oxazin-7-yl)-A/-(3-methyl-4- ((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #20, 1H NMR (CD3OD, 300 MHz) 8.68 (m, 1H), 8.48 (s, 1H), 8.38 (m, 1H), 8.00 (m, 1H), 7.49 (m, 2H), 7.21 (m, 1H), 6.96 (m, 1H), 4.23 (m, 2H), 3.74 185 186 (m, 1H), 3.50 (m, 2H), 3.24 (d, 1H), 2.94 (s, 3H), 2.65 (m, 1H), 2.32 (s, 3H), 2.89 (m, 2H), 1.54 (s, 6H); MS (ES) 472.22 (M+H); 4-(1 W-indol-6-yl)-/\/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicycfo[2.2.1 ]heptan-2- yl)phenyl)pyrimidin-2-amine, compound #21,1H NMR (300 MHz, CDCI3): δ 10.26 (b, 1H), 8.36-8.34 (m, 1H), 8.20 (b, 1H), 7.79-7.76 (d, J = 8.8 Hz, 1H), 7.67-7.64 (d, J = 8.8 Hz, 1H), 7.79-7.41 (m, 3H), 7.31 (b, 1H), 7.13-7.12 (m, 1H), 6.81-6.79 (d, J = 9 Hz, 1H), 6.51( b, 1H), 3.93 (s, 1H), 3.42-3.39 (m, 1H), 3.20-3.17 (d, J = 9.9 Hz, 1H), 2.91-2.82 (m, 1H), 2.69 (s, 4H), 2.41 (s, 3H), 2.31 (s, 3H); LCMS: purity:99%; MS (m/z); 411 (M+H)+; 4-(1/7-pyrrolo[2,3-b]pyridin-5-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine, compound #22, 1H NMR (300 MHz, CDC/3): δ 9.10-9.03 (m, 2H), 8.61 (s, 1H), 8.41-8.40 (d, J = 5.2 Hz, 1H), 7.45-7.35 (m, 3H), 7.14-7.13 (d, J = 4.1 Hz, 1H), 7.01 (s, 1H), 6.83-6.81 (d, J=8.8 Hz, 1H), 6.60 (b, 1H), 3.95 (b, 1H), 3.46-3.43 (m, 2H), 3.22-3.19 (d, J = 9.6 Hz, 1H), 2.96-2.84 (m, 2H), 2.44 (s, 3H), 2.33 (s, 3H), 1.96-1.86 (m, 2H); LCMS: purity; 100%; MS (m/z); 412 (M+H)+; 4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #23,1H NMR (300 MHz, cfe-DMSO): δ 11.86 (b, 1H), 9.55-9.46 (b, 2H), 8.97 (s, 1H), 8.64 (s, 1H), 8.44-8.42 (d, J = 5.2 Hz, 1H), 7.52-7.39 (m, 3H), 6.85 (t, J= 18.7 Hz, 1H), 6.52 (s, 1H), 4.5 (b, 1H), 4.23 (b, 1H), 3.70-3.58 (m, 2H), 3.33-3.29 (b, 1H), 3.06-3.03 (b, 1H), 2.82 (b, 3H), 2.33-2.29 (m, 1H), 2.09-2.05 (m, 1H); LCMS; purity;100%; MS (m/z); 416 (M+H)+; 4-(6-(dimethylamino)pyridin-3-yi)-A/-(3-methyl-4-((1S,4S)-5-ethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #24,1H NMR (300 MHz, CDC/3): δ 8.86 (s, 1H), 8.30 (dd, J = 1.3 and 1.6 Hz, 1H), 8.16- 8.13 (d, J = 9.0 Hz, 1H), 7.47-7.44 (d, J= 9.0 Hz, 1H), 6.96-6.94 (m, 1H), 6.87 (s, 1H), 6.80-6.78 (d, J = 7.9 Hz, 1H), 6.58-6.55 (d, J = 8.8 Hz, 1H), 3.95 (s, 1H), 3.53 (s, 1H), 3.42-3.39 (m, 1H), 3.17 (s, 6H), 3.00-2.97 (d, J=9.6Hz, 1H), 2.79- 2.76 (d, J = 9.4 Hz, 1H), 2.63-2.51 (m, 1H), 2.30 (s, 3H), 1.93-1.85 (m, 2H), 1.59 (b, 2H), 1.11-1.06 (m, 3H); LCMS: purity; 100%; MS (m/z); 430 (M+H)+; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1$,4S)-5-ethyl-2,5- diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #25,1H NMR (300 MHz, CDC/3):6 8.86 (s, 1H), 8.33-8.31 (d, J=5.2Hz, 1H), 8.19-8.17 186 187 (d, J= 8.8 Hz, 1H), 7.44-7.41 (d, J= 8.8 Hz, 1H), 7.23 (s, 1H), 6.97-6.90 (m, 2H), 6.80-6.77 (d, J= 8.5 Hz, 1H), 6.69-6.66 (d, J= 8.5 Hz, 1H). 3.95 (s, 1H), 3.82- 3.81 (m,4H), 3.64-3.61 (m, 5H), 3.43-3.40 (d, J = 9.1 Hz, 1H), 3.21-3.17 (d, J = 9.1 Hz, 1H), 3.01-2.98 (d, J = 8.8 Hz, 1H), 2.80-2.78 (d, J = 8.5 Hz, 1H), 2.64- 5 2.57 (m, 2H), 2.30 (s, 3H), 1.91-1.89 (m, 2H), 1.12-1.07 (m, 3H); LCMS: purity; 98%; MS (m/z); 472 (M+H)+; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-((ethylamino)carbonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yt)phenyl)pyrimidin-2-amine, compound #26,1H NMR (300 MHz, COC/3): δ 8.86 (s,1 H), 8.33 (dd, J= 1.3 and 1.3 Hz, 1H), 8.19 (d, 10 J = 9.4 Hz, 1H), 7.47 (d, J = 8.5 Hz, 1H), 7.29, (s, 1H), 6.98 (d, J = 6.6 Hz, 1H), 6.91-6.79 (m, 2H), 6.69 (d, J = 9.1 Hz, 1H), 4.64 (s, 1H), 4.15 (s, 1H), 4.04 (s, 1H), 3.82 (d, J = 3.5 Hz, 4H), 3.64-3.61 (m, 4H), 3.52 (d, J = 7.9 Hz, 1H), 3.44- 3.24 (m, 3H), 2.28 (s, 3H), 2.03 (d, J = 9.9 Hz, 1H), 1.88 (d, J = 8.8 Hz, 1H), 1.56 (b, 2H), 1.16-1.11 (m, 3H); LCMS: purity:96%; MS (m/z); 515 (M+H)+; 15 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazjn-7-yl)-/V-(3-methyl-4- ((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #27, 1H NMR (300 MHz, d6-DMSO): δ 9.22 (s, 1H), 8.64-8.62 (m, 1H), 8.36 (d, J = 5.2 Hz, 1H), 7.77 (s, 1H), 7.48-7.41 (m, 3H), 7.23 (d, J = 4.9 Hz, 1H), 6.82-6.77 (m, 1H),4.52 (s, 1H), 4.12 (s, 1H), 3.90-3.87 (d, J = 7.1 Hz, 1H), 3.71 20 (d, J= 5.7 Hz, 1H), 3.07-3.02 (m, 1H), 2.18 (s, 3H), 1.88-1.73 (m, 1H), 1.38-1.35 (m, 8H); LCMS: purity; 99%: MS (m/z); 459(M+H)+; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yi)-/\/-(3-iTiethyl-4- ((1S,4S)-5-(ethylcarbonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #28,1H NMR (300 MHz, d6-DMSO): δ 9.31 (s, 1H), 8.68 (s, 25 1H), 8.41-8.39 (m, 1H), 7.92 (s, 1H), 7.49-7.40 (m, 2H), 7.30 (d, J = 5.2 Hz, 1H), 6.83 (t, J= 15.9 Hz, 1H), 4.68 (b, 1H), 4.18 (d, J= 19.5 Hz, 1H), 3.51-3.38 (m, 2H), 3.14-3.05 (m, 1H), 2.19 (s, 6H)1.93-1.77 (m, 2H), 1.42 (s, 6H), 0.99-0.92 (m, 3H); LCMS: purity; 99%; MS (m/z); 514 (M+H)*; 4-(2,2-dimethy!-3-oxo-3,4-dihydro-2H-pyrido[3,2-bj[1,4]oxazin-7-yl)-N-(3-methyl-4- 30 ((1 S,4S)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2· amine, compound #29,1H NMR (300 MHz, c/6-DMSO): δ 11.47 (s, 1H), 9.36 (s, 1H), 8.73 (t, J = 3.3 Hz, 1H), 8.45 (m, 1H), 8.01 (s, 1H), 7.51 (s, 1H), 7.45 (d, J = 8.5 Hz, 1H), 7.34-7.32 (m, 1H), 6.88 (d, J = 6.8 Hz, 1H), 4.33 (s, 1H), 4.15 (s, 1H), 3.41-3.22 (m, 4H), 2.96 (d, J= 1.6 Hz, 3H), 2.21 (d, J = 1.9 Hz, 3H), 1.92- 187 188 1.80 (m, 2H), 1.45 (s, 6H); LCMS: purity; 99%; MS (m/z); 536 (M+H)+; 4-(2I2-dimethyi-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/\/-(3-methyl-4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #30, 1H NMR (300 MHz, CDC/3): δ 8.64 (s, 1H), 8.39 (d, J= 3.8 Hz, 1H), 8.06 (s, 1H), 7.87 (s, 1H), 7.46-7.38 (m, 2H), 7.00 (d, 4 = 4.1 Hz, 1H), 6.79 (d, J = 8.26 Hz, 1H), 3.94 (b, 1H), 3.53 (b, 1H), 3.39 (d, J = 9.3 Hz, 1H), 3.22 (d, J = 9.0 Hz, 1H), 2.94 (b, 4H), 2.29 (s, 3H), 1.89 (d, 7 = 6.6 Hz, 2H), 1.54 (s, 6H), 1.09 (m, 3H); LCMS: purity; 98%; MS (m/z); 486 (M+H)+; 4-(3l-oxO-3',4,-dihydrospiro[cyclobutane-1,2'-pyrido[3,2-bj[1,4]oxazine]-7'-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #31, Ή NMR (300 MHz, CDCi3): δ 8.63 (s, 1H), 8.39 (d, 5.2 Hz; 1H), 7.92 (s, 1H), 7.72 (s, 1H), 7.45-7.36 (m, 3H), 7.00 (d, J = 4.9 Hz, 1H), 6.81 (d, J = 8.2 Hz, 1H), 3.94 (s, 1H), 3.41 (d, J = 4.9 Hz, 2H), 3.22 (d, J = 8.5 Hz, 1H), 2.93-2.82 (m, 3H), 2,67 (b, 4H), 2.41-2.26 (m, 6H), 2.01-1.84 (m, 3H); LCMS: purity; 95%; MS (m/z); 484 (M+H)+; 4-(3,-oxo-3',4,-dihydrospiro[cyclobutane-1t2’-pyrido[3,2-b][1,4]oxazine]-7’-yl)-A/-(3-methyl-4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #32,1H NMR (300 MHz, COC/3): δ 8.63 (s, 1H), 8.39 (d, J = 4.9 Hz, 1H), 7.96 (d, J = 13.7 Hz, 2H), 7.49-7.37(m, 2H), 7.00 (d, J = 5.2 Hz, 1 H)6.79 (d, J = 8.2 Hz, 1H), 3.94 (s, 1H), 3.53 (s, 1H), 3.39 (d, J = 9.0 Hz, 1H), 3.22 (d, J = 9.0 Hz, 1H), 2.98 (d, J = 9.3 Hz, 2H), 2.80 (d, J - 9.3 Hz, 1H), 2.66-2.51 (m, 5H), 2.37-2.25 (m, 5H), 2.03-1.84 (m, 3H), 1.09 (t, 13.7 Hz, 3H); LCMS; purity; 97%; MS (m/z); 498 (M+H)+; 4-(1/-/-pyrrolo[2,3-b]pyridin-5-yl)-A/-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #33,1H NMR (300 MHz, d6-DMSO); δ 9.30 (s, 1H), 9.01 (d, J = 1.6 Hz, 1H), 8.67 (s, 1H), 8.43 (d, J = 5.2 Hz, 1H), 7.55-7.50 (m, 2H), 6.84 (d, J = 8.5 Hz, 1H), 6.56 (d, J = 3.3 Hz, 1H), 4.52 (s, 1H), 4.14 (s, 1H), 3.92 (d, J = 7.1 Hz, 2H),3.73 (d, J = 5.7 Hz, 2H), 3.08 (d, J = 9.3 Hz, 1H), 2.21 (s, 3H), 1.90-1.78 (m, 2H); LCMS: purity 95%; MS (m/z); 399 (M+H)+; 4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-(2,2,2-trifluoroethyl)-2l5-diazabicyclo[2.2,1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #34, 1H NMR (300 MHz, c/6-DMSO): δ 9.30 (s, 1H), 9.02 (t, J= 9.6 Hz, 1H), 8.68 (t, J = 9.9 Hz, 1H), 8.43 (t, J = 5.2 Hz, 1H), 7.55 (m, 4H), 7.38 (m, 1H), 6.80 (d, J = 8.8 Hz, 1H), 6.57-6.52 (m, 1H), 3.96-2.85 (m, 7H), 2.22-2.19 (m, 4H), 1.77 (b, 2H); 188 189 LCMS: purity; 96%; MS (m/z); 480 (M+Hf; 4-(1 A-/-pyrrolo[2,3-£&gt;]pyridir»-5-yl)-/V-(3-methyi-4-((1 S,4S)-5-(cyciopropyl)methyl-2,5-

diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #35,1H NMR (300 MHz, d6-DMSO): δ 9.18 (b, 1H), 8.95 (t, J = 8.2 Hz, 1H), 8.59 (d, J = 5 1.9 Hz, 1H), 8.33 (d, J= 5.2 Hz, 1H), 7.46-7.37 (m, 4H), 7.28 (d, J = 5.5 Hz, 1H), 6.68 (d, J- 8.5 Hz, 1H), 6.47 ( d, J = 3.5 Hz, 1H), 3.82 (b, 1H), 2.81 (d, J = 7.4 Hz, 1H), 2.62 (d, J= 8.8 Hz, 1H), 2.41 (b, 2H), 2.27 (d, J = 6.3 Hz, 2H), 2.13 (s, 3H), 1.65-1.63 (m, 3H), 0.71 (b, 1H), 0.33-0.30 (m, 2H), 0.00-01 (m, 2H); LCMS: purity; 95%; MS (m/z); 452 (M+Hf; 10 4-(6-(morpholin-4-yi)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-(2,2,2-trifluoroethyi)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #36,1H NMR (300 MHz, d6-DMSO): δ 9.21 (b, 1H), 8.90 (b, 1H), 8.37-8.34 (m, 1H), 8.25 (d, J = 6.6 Hz, 1H), 7.46 (b, 2H), 7.24-7.20 (m, 1H), 6.98-6.93 (m, 1H), 6.79-6.74 (m, 1H), 3.95 (b, 1H), 3.70 (b, 4H), 3.57 (b, 4H), 2.97 (b, 2H), 2.87-2.84 (m, 2H), 15 2.21-2.20 (m, 5H), 1.77 (b, 3H); LCMS: purity; 99%; MS (m/z); 526 (M+Hf; 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-(cyclopropyl)methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #37,1H NMR (300 MHz, d6-DMSO): δ 9.18 (b, 1H), 8.89 (b, 1H), 8.35-8.22 (m, 2H), 7.46-7.42 (d, J = 12.1 Hz, 2H), 7.21-7.19 (m, 1H), 6.95 (d, J = 9.0 Hz, 1H), 6.72 (d, d = 20 7.9 Hz, 1H), 3.88 (b, 1H), 3.68 (b, 4H), 3.57 (b, 4H), 3.15 (s, 2H), 2.87 (d, 7 = 8.8

Hz, 1H), 2.69 (d, J = 9.3 Hz, 1H), 2.48 (b, 1H), 2.34 (d, J = 5.7 Hz, 2H), 2.18 (s, 3H), 1.71 (d, J = 6.3 Hz, 2H), 0.78 (b, 1H), 0.40 (t, J = 7.7 Hz, 2H), 0.06 (b, 2H); LCMS: purity; 98%; MS (m/z); 498 (M+Hf; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4- 25 ((1S,4S)-5-(aminosulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2- amine, compound #38,1H NMR (300 MHz, de-DMSO): δ 11.50 (d, J =7.7 Hz, 1H), 9.47 (b, 1H), 8.73 (d, J = 6.33 Hz, 1H), 8.46 (t, J = 13.2 Hz, 1H), 8.02 (d, J = 7.1 Hz, 1H), 7.53-7.33 (m, 4H), 6.94 (b, 3H), 4.23 (d, J = 7.7 Hz, 2H), 3.37 (m, 4H), 1.92-1.85 (m, 2H), 1.47-1.38 (m, 8H); LCMS; purity; 100%; MS (m/z); 537 30 (M+Hf; 4-(3-fiuoro-2-(morpholin-4-yl)pyridin-4-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #39,1H NMR (DMSO-d6): δ 9.68 (s, 1H), 8.55 (dd, 1H, J = 1.4 and 4.9 Hz), 8.15 (d, 1H, J = 4.9 Hz), 7.62 (d, 1H, J= 15.4 Hz), 7.31-7.28 (m, 2H), 7.15-7.14 (m, 1H), 6.67 (t, 189 190 1H, J = 9.1 Hz), 4.15 (s, 1H), 3.73-3.71 (m, 4H), 3.39-3.37 (m, 5H), 3.15 (app d, 1H, 7 = 6.1 Hz), 2.70 (d, 1H, 7 = 9.0 Hz), 2.57 (d, 1H,7 = 9.0 Hz), 2.22 (s, 3H), 1.79 (d, 1H, 7 = 9.0 Hz), 1.68 (d, 1H, 7= 9.0 Hz); LCMS: purity: 99%; MS (m/e): 480 (MH+); 5 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-/V-(4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #40,1H NMR (CD3OD, 300 MHz): δ 9.02 (s, 2H), 8.26 (d, 1H), 7.45 (d, 2H), 7.08 (d, 1H), 6.63 (d, 2H), 4.31 (s, 1H), 3.89 (m, 4H), 3.75 (m, 4H), 3.45 (m, 2H), 2.81 (m, 2H), 2.65 (m, 2H), 2.39 (m, 2H), 2.37 (s, 3H), 1.98 (m, 2H); LCMS (m/z): 445.54 10 (MH+); 4-(2-(morphoiin-4-yl)pyrimidin-5-yl)-/V-(3-methyl-4-((1S,4$)-5-methyl-2,5“ diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #41, 1H NMR (CD3OD, 300 MHz): δ 9.02 (s, 2H), 8.54 (s, 1H), 8.29 (d, 1H), 7.38 (m, 1H), 7.08 (d, 1H), 6.87 (d, 1H), 4.00 (s, 1H), 3.89 (m, 4H), 3.75 (m, 4H), 3.56 (m, 1H), 15 3.42 (m, 1H), 3.25 (m, 1H), 3.04 (m, 1H), 2.86 (m, 1H), 2.65 (m, 1H), 2.49 (s, 3H), 2.29 (m, 3H), 1.96 (m, 2H); LCMS (m/z): 459.57 (MH+); 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-/V-(3-methyf-4-((1Sl4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #42,1H NMR (CD3OD, 300 MHz): δ 9.02 (s, 2H), 8.32 (m, 1H), 7.96 (m, 1H), 7.38 (m, 1H), 7.12 20 (m, 1H), 6.80 (m, 1H), 4.58 (s, 1H), 4.07 (m, 1H), 3.85 (m, 2H), 3.81 (m, 1H), 3.76 (m, 2H), 3.36 (m, 1H), 3.34 (s, 3H), 3.00 (m, 1H), 2.86 (m, 1H), 2.66 (m, 1H), 2.29 (m, 2H), 2.20 (m, 2H), 2.01 (m, 1H), 1.89 (m, 1H); LCMS (m/z): 446.39 (MH+); 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #43,1H 25 NMR (CD3OD, 300 MHz): δ 9.03 (s, 2H), 8.53 (s, 1H), 8.33 (d, 1H), 7.57 (m, 1H), 7.23 (d, 1H), 7.13 (d, 1H), 6.74 (m, 1H), 4.46 (s, 1H), 3.90 (m, 4H), 3.76 (m, 4H), 3.66 (m, 1H), 3.40 (m, 1H), 3.36 (m, 1H), 3.14 (m, 1H), 2.96 (m, 1H), 2.57 (m, 1H), 2.52 (s, 3H), 2.04 (m, 2H); LCMS (m/z): 463 (MH+); 4-(2-( (cyclopropyl)carbonylamino)-pyrimidin-5-yl)-/\/-(3-methyl-4-((1S)4S)-5-methyl-2,5-

30 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #44,1H NMR (CD3OD, 300 MHz): δ 9.17 (s, 2H), 8.36 (s, 1H), 7.41 (d, 1H), 7.18 (m, 1H), 7.08 (d, 1H), 6.80 (d, 1H), 4.30 (s, 1H), 4.16 (m, 1H), 4.05 (m, 1H), 3.78 (m, 1H), 3.58 (m, 1H), 3.32 (m, 1H), 2.89 (s, 3H), 2.47 (m, 1H), 2.65 (m, 1H), 2.26 (m, 3H), 2.21 (m, 1H), 1.13 (m, 2H), 0.92 (m, 2H); LCMS (m/z): 457 (MH+); 190 191 4-(4-(4,5-dihydrothiazol-2-ylcarbamoyl)phenyl)-W-(3-methyl-4-((1 S,4S)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #45, LCMS (m/z): 500 (MH+); 4-(4-(1, l-dimethylethyOphenyO-N-^-methyl-A-^ISASj-S-methy!^, 5-

5 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #46,1H NMR (CD3OD, 300 MHz): δ 8.34 (m, 2H), 8.04 (m, 2H), 7.56 (m, 1H), 7.53 (m, 2H), 7.20 (m, 1H), 6.97 (m, 1H), 4.25 (d, 2H), 3.80 (m, 1H), 3.5 (m, 2H), 2.97 (m, 3H), 2.30 (m, 6H), 1.36 (m, 9H); LCMS (m/z): 428 (MH+); 4-(4-(morpholin-4-yl)phenyl)-W-(3-fluoro-4-((1S,4S)-5-methyl-2,5-10 diazabicyclo(2,2.1]heptan-2-yl)phenyl)pynmidin-2-amine.TFA salt, compound #47, 1H NMR (DMSO-cfe): δ 9.54-9.42 (2H, m), 8.39 (1H, d, J = 5.5 Hz), 8.04 (2H, d, J = 8.8 Hz), 7.80 (1H, dd, J = 16.4, 2.3 Hz), 7.41 (1H, dd, J = 8.7, 2.1 Hz), 7.27 (1H, d, J = 5.2 Hz), 7.05 (2H, d, J = 9.1 Hz), 6.84 (1H, t, J = 9.6 Hz), 4.48 (1H, s), 4.27 (1H, s), 3.79-3.67 (6H, m), 3.34 (1H, d, 7 = 10.7 Hz), 3.26 (4H, app. t, 7 = 4.7 15 Hz), 3.09 (1H, d, 7 = 11.6 Hz), 2.87 (2H, d, 7 = 5.0 Hz), 2.82 (1H, d, 7 = 5.0 Hz), 2.35 (1H, d, J = 11.0 Hz), 2.11 (1H, d, J = 11.0 Hz); MS: 461 (M+H)+; 4-(4-((methyl)arninocarbony!methyl)-phenyl)-W-(3-methyl-4-((1S,4S)-5-methyi-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine.TFA salt, compound #48, 1H NMR (CD3OD): δ 8.32 (1H, d, 7 = 6.1 Hz), 8.15 (2H, d, 7 = 8.5 Hz), 7.46 20 (3H, d, 7 = 8.5 Hz), 7.42 (2H, d, 7 = 6.1 Hz), 7.02 (1H, d, 7 = 8.3 Hz), 4.32 (2H, br s), 3.98 (1H, d, 7 = 11.3 Hz), 3.60 (2H, s), 3.52 (2H, d, J = 9.4 Hz), 3.18 (1H, d, J = 11.6 Hz), 3.00 (3H, s), 2.75 (3H, s), 2.40-2.28 (5H, m); MS: 443 (M+H)-TFA*;

4-(4-((cyc!opropyl)aminocarbonyl-methyl)phenyl)-W-(3-methyl-4-((1$,4S)-5-methyl-2,5-diazabicyclo[2.2.1jheptan-2-yl)phenyl)pyrimidin-2-amine, compound #49, 1H 25 NMR (CD3OD): δ 8.31 (1H, d, 7 = 6.1 Hz), 8.15 (2H, d, 7 = 8.5 Hz), 7.47-7.43 (5H, m), 7.03 (1H, d, 7 = 8.3 Hz), 4.33 (2H, d, 7 = 7.2 Hz), 3.99 (1H, d, 7 = 11.0 Hz), 3.60-3.47 (4H, m), 3.18 (1H, d, 7 = 11.8 Hz), 3.00 (3H, s), 2.71-2.66 (1H, m), 2.40-2.28 (5H, m), 0.77-0.71 (2H, m), 0.53-0.48 (2H, m); MS: 469 (M+H)+; 4-(6-(methylaminocarbonyl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4$)-5-methyl-2,5-

30 dtazabicyclo[2.2.1]heptan-2-yl)phenyl)pynmidin-2-amine, compound #50, 1H NMR (CD3OD): δ 9.31-9.30 (1H, m), 8.60 (1H, dd, 7 = 8.3, 2.2 Hz), 8.51-8.44 (2H, m), 8.16 (1H, d, 7 = 8.3 Hz), 7.54 (1H, dd, 7 = 8.7, 2.6 Hz), 7.49 (1H, d, J = 2.2 Hz), 7.33 (1H, d, 7 = 5,0 Hz), 6.96 (1H, d, 7 = 8.5 Hz), 4.26 (2H, d, 7 = 11.6 Hz), 3.77 (1H, d, 7 = 11.3 Hz), 3.54 (1H, d, 7 = 11.3 Hz), 3.45 (1H, dd, 7 = 11.4, 2.6 191 192

Hz), 3.26 (1H, dd, J = 11.3, 2.2 Hz), 3.00 (3H, s), 2.97 (3H, s), 2.32 (3H, s), 2.30 (2H, d, J = 2.8 Hz); MS: 430 (M+H)+; 4-(7-oxo-5,6,7,8-tetahydro-1,8-naphthyridin-3-yl)-N-(3-methyl-4-((1S,4$)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yi)phenyi)pyrimidin-2-amine.TFA salt, compound #51 x, 1H NMR (DMSO-d6): δ 10.75 (1H, s), 9.44 (1H, s), 8.90 (1H, d, J = 1.9 Hz), 8.46 (1H, d, J = 5.2 Hz), 8.29 (1H, s), 7.59-7.51 (2H, m), 7.34 (1H, d, J = 5.2 Hz), 6.93 (1H, d, J = 8.8 Hz), 4.28-4.22 (2H, m), 3.43-3.38 (2H, m), 3.06-2.87 (7H, m), 2.61-2.53 (4H, m), 2.34-2.08 (3H, m), MS: 442 (M+H)-TFA+; 4-(5-((morpholin-4-yl)carbonyl)pyridin-3-yl)-/V-(3-methyl-4-((1 $,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine. Bis TFA salt, compound #52, Ή NMR (CD3OD): δ 9.36 (1H, d, J = 2.2 Hz), 8.74 (1H, d, J = 1.9 Hz), 8.59 (1H, dd, J = 2.2,1.9 Hz), 8.49 (1H, d, J = 5.2 Hz), 8.47 (1H. s), 7.53-7.50 (2H, m), 7.37 (1H, d, J = 5.2 Hz), 6.97 (1H, d, J = 9.4 Hz), 4.27 (2H, d, J = 11.0 Hz), 3.80- 3.66 (8H, m), 3.54 (2H, d, J= 11.6 Hz), 3.47 (2H, dd, J = 11.6, 2.5 Hz), 2.97 (3H, s), 2.33 (3H, s), 2.30 (2H, br s); MS: 486 (M+H)*; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-cyano-4- ((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #53,1H NMR (DMSO-d6): δ 11.50 (1H, s), 9.69 (1H, s), 8.73 (1H, s), 8.52 (1H, d, J = 5.2 Hz), 8.13 (1H, d, J = 1.9 Hz), 8.03 (1H, s), 7.78 (1H, d, J = 9.4 Hz), 7.43 (1H, d, J = 5.0 Hz), 7.01 (1H, d, J = 9.1 Hz), 4.71 (1H, s), 4.36 (1H, s), 3.98 (1H, d, J = 9.1 Hz), 3.72 (2H, d, J = 10.7 Hz), 3.12 (1H, d, J = 10.7 Hz), 2.86 (2H, d, J = 4.4 Hz), 2.80 (1H, br s), 2.41 (1H, d, J = 11.8 Hz), 2.18 (1H, d, J = 70.7 Hz), 1.47 (6H, s); MS: 483 (M+Hf; 4-(5-methyl-6-(morphoiin-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1Jheptan-2-yl)phenyl)pyrimidin-2-amine, compound #59, LCMS: purity: 99%; MS (m/e): 476 (MH+); 4- (5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #60, LCMS: purity: 99%; MS (m/e): 472 (MH+); 5- methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((15,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine, compound #67, LCMS: purity: 99%; MS (m/e): 472 (MH+); 5-methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-fiuoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #68, LCMS: purity: 99%; MS (m/e): 476 (MH+); 192 193 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #69, LCMS: purity: 99%; MS (m/e): 487 (MH+); 4-(6~(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(3-fluoro-4-((1$,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #70, LCMS: purity: 99%; MS (m/e): 505 (MH+); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido(3,2-5)(1,4joxazin-7-yl)-A/-(3-methyl-4- ((1ft,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #71, 1H NMR (DMSO-d6): 6 9.81 (s, 1H), 9.23 (s, 1H), 8.95 (m, 1H), 8.52 (s, 1H), 7.88 (m, 3H), 7.24 (d, 1H, 7= 3.6 Hz), 4.29 (s, 1H), 3.82 (s, 2H), 3.69 (s, 2H), 3.20 (m, 2H), 2.98 (s, 4H), 2.77 (s, 2H), 2.70 (s, 2H), 1.95 (s, 6H); LCMS: purity: 99%; MS (m/e): 476 (MH+); 4-(6-(morphoiin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1R,4R)-5-methyl-2l5- diazabicyclo(2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #72,1H NMR (DMSO-d6): δ 9.29 (s, 1H), 8.92 (d, 1H, J = 2.4 Hz), 8.37 (d, 1H, J = 5.4 Hz), 8.25 (m, 1H), 7.54 (m, 2H), 7.24 (d, 1H, J = 5.4 Hz), 6.95 (d, 1H, J = 9.3 Hz), 6.85 (d, 1H 7 = 9.3 Hz), 4.07 (s, 1H), 3.69 (m, 4H), 3.58 (m, 4H), 3.32 (m, 4H), 2.65 (s, 3H), 2.19 (s, 3H), 1.95 (m, 2H); LCMS; purity: 99%; MS (m/e): 458 (MH+); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-5)(1,4]oxazin-7-yl)-A/-(3-fluoro-4- ((1 R,4R)-5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #73, LCMS: purity: 99%; MS (m/e): 476 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-fluoro-4-((1R,4R)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #74, LCMS: purity: 99%; MS (m/e): 462 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3l7- diazabicyclo(3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #75,1H NMR (DMSO-d6): δ 8.92 (d, 1H, 7 = 2.1 Hz), 8.38 (d, 1H, 7 = 5.1 Hz), 8.25 (m, 1H), 7.56 (m, 3H), 7.25 (d, 1H, 7 = 4.8 Hz), 6.95 (d, 1H, 7 = 9.3 Hz), 3.68 (m, 4H), 3.58 (m, 4H), 3,31 (m, 8H), 2.91 (s, 2H), 2.31 (s, 3H), 0.87 (s, 6H); LCMS: purity: 99%; MS (m/e): 514 (MH+); 4-(6-(dimethylamino)pyridin-3-yi)-A/-(3-methyl-4-(1,5,7-trimethyl-3l7- diazabicyclo(3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #76, LCMS: purity: 99%; MS (m/e): 472 (MH+); 4-(6-(cyclohexylamino)pyridin-3-y!)-N-(3-methyt-4-(1l5,7-trimethyl-3,7- 193 194 diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #77, LCMS: purity: 99%; MS (m/e): 526 (MH+); 4-(6-(cyclohexylamino)pyridin-3-yi)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5“ diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #78, LCMS: purity: 99%; MS (m/e): 470 (MH+); 4-(6-(cyclohexylamino)pyridin-3-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #79, LCMS: purity; 99%; MS (m/e): 474 (MH*); 4-(6-(benzylamino)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyi-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #80, LCMS; purity: 99%; MS (m/e): 478 (ΜΗ*); 4-(6-(benzylamino)pyridin-3-yl)-/S/-(3-fluoro-4-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #81, LCMS; purity: 99%; MS (m/e): 482 (MH+); 4-(5-methyl-6-(morpholin-4-yi)pyridin-3-yl)-N-(3-fluoro-4«(1,5,7-trimethyl-3,7- diazabicycloi3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #82, LCMS: purity: 99%; MS (m/e): 532 (MH+); 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3~fiuoro-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #83, LCMS: purity: 99%; MS (m/e): 476 (MH+); 4-(4-(dimethylamino)phenyl)-A/-(3-fluoro-4-(1l5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan- 3-yl)phenyl)pyrimidin-2-amine, compound #84, LCMS: purity: 99%; MS (m/e): 475 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-fluoro-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #85, LCMS: purity: 99%; MS (m/e): 518(MH+); 4-(3,4-dihydro-2H-pyndo[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #86, LCMS; purity: 99%; MS (m/e): 430 (MH+); 4-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #87, LCMS; purity: 99%; MS (m/e): 434 (MH+); 4-(3,4-dihydro-2H-pyndo[3,2-b][1l4]oxazin-7-yi)-W-(3-methyl-4-(1,5,7-trimethyi-3)7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #88, LCMS: purity: 99%; MS (m/e): 486 (MH+); 194 195 4-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-fluoro-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyi)pyrimidin-2-amine, compound #89, LCMS: purity: 99%; MS (m/e): 490 (MH+); 4-(6-(benzyl)pyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #90, LCMS: purity: 99%; MS (m/e): 534 (MH+); 4-(6-(benzyl)pyridin-3-yl)-A/-(3-fluoro-4-(1,5,7-tnmethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #91, LCMS: purity: 99%; MS (m/e): 538 (MH+); 4-(2~(propyl)aminopyrimidin-5-yl)-/V-(3-methyl-4-((1Sl4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #92, LCMS: purity: 99%; MS (m/e): 431 (MH+); 4-(2-(propyl)aminopyrimidin-5-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclop^.ljheptan^-yljphenyljpyrimidin^-amine. compound #93, LCMS: purity: 99%; MS (m/e): 435 (MH+); 4-(6-(cyclohexylamino)pyridin-3-yl)-/\/-(3-tifluorornethy!-4-((1S,4S)-5-methyl-215- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #94, LCMS: purity: 99%; MS (m/e): 524 (MH+); 4-(5-(methyl)sulfonylpyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-215- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #95, LCMS: purity: 99%; MS (m/e): 451 (MH+); 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3-tifluoromethyl-4-((1Sl4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #96, LCMS: purity: 99%; MS (m/e): 470 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-tifluoromethyl-4-((1S,4S)-5-methy 1-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #97, LCMS: purity: 99%; MS (m/e): 512 (MH+); 4-(3,4-dihydro-2H-pyrido[3,2-5][1,4]oxazin-7-yl)-A/-(3-tifluoromethyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #98, LCMS: purity: 99%; MS (m/e): 484 (MH+); 4-(6-((2-(cyclopropylsulfonyl)aminoethyl)-amino)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #99, LCMS: purity: 99%; MS (m/e): 535 (MH+); 4-(6-((2-(cyclopropylsulfonyl)aminoethyl)-amino)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5~ oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #100, 195 196 LCMS: purity: 99%; MS (m/e): 522 (MH+); 4-(5-(methyl)sulfonylpyridin-3-yl)-N-(3-fluoro-4-((1S,4S)-5-methy!-2,5- diazabicyclol2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #101, LCMS: purity: 99%; MS (m/e): 455 (MH+); 4-(5-(methyl)sulfonylpyridin-3-yl)-A/-(3-tifluoromethyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #102, LCMS: purity: 99%; MS (m/e): 505 (MH+); 4-(imidazo[1,2-a]pyridin-6-yl)-N-(3-methyl-4-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #103,1H NMR (CD3OD, 300 MHz): δ 9.29 (s, 1H), 8.42 (m, 1H), 8.06 (m, 1H), 7.96 (s, 1H), 7.64 (m, 2H), 7.55 (m, 1H), 7.49 (m, 1H), 7.27 (m, 1H), 6.99 (m, 1H), 4.29 (m, 2H), 3.79 (m, 1H), 3.52 (m, 3H), 2.99 (s, 3H), 2.32 (m, 5H); MS (ES) 412.0 (M+H); 4-(4-(5-(4-dimethylaminophenyl)oxazol-2-yl)phenyl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #104, 1H NMR (CD3OD, 300 MHz): δ 8.32 (m, 1H), 8.22 (m, 2H), 8.06 (m, 2H), 7.61 (m, 2H), 7.43 (m, 4H), 6.98 (m, 3H), 4.31 (m, 2H), 3.98 (m, 1H), 3.52 (m, 2H), 3.17 (m, 1H), 3.05 (m, 9H), 2.33 (m, 5H&gt;; MS (ES) 558.1 (M+H); 4-(6-methoxy-1W-indoi-2-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #105,1H NMR (CD3OD, 300 MHz): δ 7.98 (m, 1H), 7.51 (m, 1H), 7.44 (s, 1H), 7.37 (m, 1H), 7.28 (m, 2H), 7.03 (m, 1H), 6.93 (m, 1H), 6.76 (m, 1H), 4.34 (m, 2H), 3.98 (m, 1H), 3.85 (s, 3H), 3.54 (m, 3H), 2.99 (s, 3H), 2.32 (m, 5H); MS (ES) 441.1 (M+H); 4-(1-(3-chlorophenyl)-1H-pyrazol-4-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #106,1H NMR (CD3OD, 300 MHz): δ 9.10 (m, 1H), 8.35 (m, 1H), 8.20 (m, 1H), 7.92 (m, 1H), 7.79 (m, 1H), 7.50 (m, 1H), 7.40 (m, 3H), 7.27 (m, 1H), 7.03 (m, 1H), 4.34 (m, 2H), 3.98 (m, 1H), 3.54 (m, 2H), 3.18 (m, 1H), 2.99 (s, 3H), 2.32 (m, 5H); MS (ES) 472.0 (M+H); 4-(1-ηιβ0ψΙόθηζίηιίύ3ζοΙ-6^Ι)-Ν-(3-[ΤΐθίΚ^-4-((1δ,45)-5-Γηβ^Ι-215- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #107,1H NMR (CD3OD, 300 MHz): δ 9.41 (s, 1H), 8.73 (s, 1H), 8.47 (m, 2H), 7.96 (m, 1H), 7.53 (m, 3H), 7.02 (m, 1H), 4.31 (m, 2H), 4.21 (s, 3H), 3.97 (m, 1H), 3.51 (m, 2H), 196 197 3.19 (m, 1 Η), 2.99 (s, 3H), 2.34 (m, 5H); MS (ES) 426.1 (M+H); 4-(5-cyano-1H-indol-2-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #108,1H NMR (CD3OD, 300 MHz): δ 8.17 (m, 1H), 8.01 (m, 1H), 7.56 (m, 1H), 7.39 (m, 5H), 7.01 (m, 1H), 4.32 (m, 2H), 3.97 (m, 1H), 3.53 (m, 2H), 3.16 (m, 1H), 2.99 (s, 3H), 2.31 (m, 5H); MS (ES) 436.1 (M+H); 4-(1 -(4-fluorophenyl)-1 /7-pyrazol-4-yl)-A/-(3-methy!-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #109,1H NMR (CD3OD, 300 MHz): δ 8.75 (s, 1H), 8.26 (m, 2H), 7.79 (m, 2H), 7.46 (m, 2H), 7.23 (m, 2H), 7.00 (m, 1H), 6.93 (m, 1H), 4.22 (m, 2H), 3.73 (m, 1H), 3.53 (m, 1H), 3.33 (m, 1H), 3.22 (m, 1H), 2.94 (s, 3H), 2.28 (m, 5H); MS (ES) 456.0 (M+H); 4-(6-(morpholin-4-yl)pyndin-3-yi)-/V-(3-methyl-4-(7-azabicyclo[2.2.1]heptan-7- yl)phenyl)pyrimidin-2-amine, compound #110,1H NMR (CD3OD, 300 MHz): δ 8.87 (m, 1H), 8.58 (m, 1H), 8.50 (m, 1H), 7.81 (m, 2H), 7.60 (m, 1H), 7.36 (m, 2H), 4.80 (m, 2H), 3.85 (m, 4H), 3.76 (m, 4H), 2.57 (s, 3H), 2.22 (m, 4H), 1.98 (m, 4H); MS (ES) 443.1 (M+H); 4-(6-cyanopyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #111,1H NMR (CD3OD, 300 MHz): δ 9.48 (m, 1H), 8.64 (m, 2H), 8.05 (m, 1H), 7.90 (m, 2H), 7.64 (m, 1H), 7.46 (m, 1H), 4.31 (m, 2H), 3.97 (m, 1H), 3.50 (m, 2H), 3.18 (m, 1H), 2.99 (s, 3H), 2.30 (m, 5H); MS (ES) 398.1 (M+H); 4-(6-cyanopyridin-3-yl)-/V-(3-methyl-4-(7-azabicyclo[2.2.1]heptan-7-yl)phenyl)pynmidin-2-amine, compound #112, 1H NMR (CD3OD, 300 MHz): δ 9.47 (m, 1H), 8.66 (m, 2H), 8.03 (m, 1H), 7.87 (m, 2H), 7.60 (m, 1H), 7.51 (m, 1H), 4.81 (m, 2H), 2.57 (s, 3H), 2.22 (m, 4H), 1.98 (m, 4H); MS (ES) 383.0 (M+H); 4-(2-oxoindolin-5-yl)-/V-(3-methyl-4((1S,4S)-5-methyl-2,5-diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #113,1H NMR (CD3OD, 300 MHz): δ 8.25 (m, 3H), 7.41 (m, 3H), 7.02 (m, 2H), 4.32 (m, 2H), 3.98 (m, 1H), 3.54 (m, 2H), 3.18 (m, 1H), 2.99 (m, 5H), 2.33 (m, 5H); MS (ES) 427.0 (M+H); 4-(5-cyanopyridin-3-yl)-/V-(3-methyl-4((1SI4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #114,1H NMR (CD3OD, 300 MHz): δ 8.82 (m, 2H), 7.42 (m, 4H), 6.97 (m, 2H), 4.30 (m, 2H), 3.97 (m, 1H), 3.49 (m, 2H), 3.17 (m, 1H), 2.98 (s, 3H), 2.30 (m, 5H); MS (ES) 398.1 (M+H); 197 198 4-(6-(1 B-tetrazol-5-yl)pyridin-3-yl)-A/-(3-methyl-4((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #115, 1H NMR (CD3OD, 300 MHz); δ 9.49 (m, 1H), 8.72 (m, 1H), 8.51 (m, 1H), 8.36 (m, 1H), 7.53 (m, 2H), 7.40 (m, 1H), 6.98 (m, 1H), 4.29 (m, 2H), 3.96 (m, 1H), 3.49 (m, 2H), 3.16 (m, 1H), 2.65 (s, 3H), 2.32 (m, 5H); MS (ES) 441.1 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-cyano-4-((1S14$)-5-acetyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #116,1H NMR (CD3OD, 300 MHz): δ 8.79 (m, 1H), 8.39 (m, 1H), 8.31 (m, 1H), 7.86 (m, 1H), 7.59 (m, 1H), 7.29 (m, 1H), 7.12 (m, 1H), 6.87 (m, 1H), 4.04 (m, 2H), 3.80 (m, 4H), 3.58 (m, 8H), 2.07 (m, 5H); MS (ES) 497.1 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-cyano-4-((1S,4S)-5-methylsulfonyl-2,5- diazabicyclo[2.2.1jheptan-2-yl)phenyl)pyrimidin-2-amine, compound #117,1H NMR (CD3OD, 300 MHz): δ 8.83 (m, 1H), 8.41 (m, 1H), 8.32 (m, 1H), 7.88 (m, 1H), 7.60 (m, 1H), 7.34 (m, 1H), 7.17 (m, 1H), 6.93 (m, 1H), 4.55 (m, 2H), 4.04 (m, 3H), 3.82 (m, 5H), 3.73 (m, 4H), 2.96 (s, 3H), 2.01 (m, 2H); MS (ES) 533.1 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-cyano-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #118,1H NMR (CD3OD, 300 MHz): δ 8.83 (m, 1H), 8.49 (m, 1H), 8.39 (m, 1H), 8.00 (m, 1H), 7.74 (m, 1H), 7.33 (m, 1H), 7.22 (m, 1H), 6.98 (m, 1H), 4.83 (m, 1H), 4.41 (m, 1H), 4.05 (m, 3H), 3.85 (m, 4H), 3.74 (m, 4H), 3.65 (m, 1H), 3.00 (s, 3H), 2.39 (m, 2H); MS (ES) 469.1 (M+H); 4-(6-(morpholin-4-y!)pyridin-3-yl)-A/-(3-cyano-4-((1S,4S)-5-cyclopentyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #119,1H NMR (CD3OD, 300 MHz): δ 8.83 (m, 1H), 8.49 (m, 1H), 8.40 (m, 1H), 8.01 (m, 1H), 7.75 (m, 1H), 7.34 (m, 1H), 7,23 (m, 1H), 6.99 (m, 1H), 4.57 (m, 1H), 4.08 (m, 1H), 3.81 (m, 11H), 3.46 (m, 1H), 2,33 (m, 2H), 1.76 (m, 8H); MS (ES) 523.1 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4- yl)phenyl)pyrimidin-2-amine, compound #120, 1H NMR (CD3OD, 300 MHz): δ 8.93 (m, 1H), 8.40 (m, 1H), 8.29 (m, 1H), 7.74 (m, 1H), 7.52 (m, 2H), 7.29 (m, 1H), 7.19 (m, 1H), 7.05 (m, 1H), 3.97 (m, 1H), 3.82 (m, 4H), 3.69 (m, 9H), 3.37 (m, 1H), 3.14 (m, 2H), 2.37 (s, 3H), 2.16 (m, 2H); MS (ES) 458.1 (M+H); 4-(2-oxoindolin-5-yl)~A/-(3-methyl-4-(1,4-diazabicyclo[3.2.1 ]octan-4-yl)phenyl)pyrimidin-2- 198 199 amine, compound #121,1H NMR (CD3OD, 300 MHz): δ 8.20 (m, 3H), 7.44 (m, 3H), 7.12 (m, 2H), 3.95 (m, 1H), 3.60 (m, 5H), 3.36 (m, 1H), 3.10 (m, 4H), 2.37 (s, 3H), 2.16 (m, 2H); MS (ES) 427.0 (M+H); (1 -methy lbenzimidazol-6-yl)-A/-(3-methyl-4-(1,4-diazabicycio[3.2.1 ]octan-4- 5 yl)phenyl)pyrimidin-2-amine, compound #122,1H NMR (CD3OD, 300 MHz): δ 8.40 (m, 2H), 8.24 (m, 1H), 8.14 (m, 1H), 7.76 (m, 1H), 7.67 (m, 1H), 7.60 (m, 1H), 7.39 (m, 1H), 7.14 (m, 1H), 3.99 (s, 3H), 3.94 (m, 1H), 3.60 (m, 5H), 3.36 (m, 1H), 3.14 (m, 2H), 2.38 (s, 3H), 2.16 (m, 2H); MS (ES) 426.1 (M+H); 4-(imidazo[1,2-a]pyridin-6-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.1 ]octan-4-10 yl)phenyl)pyrimidin-2-amine, compound #123,1H NMR (CD3OD, 300 MHz): δ 9.30 (m, 1H), 8.45 (m, 1H), 8.39 (m, 1H), 8.07 (m, 1H), 7.96 (m, 1H), 7.60 (m, 3H), 7.30 (m, 1H), 7.15 (m, 1H), 3.95 (m, 1H), 3.60 (m, 5H), 3.36 (m, 1H), 3.14 (m, 2H), 2.37 (s, 3H), 2.16 (m, 2H); MS (ES) 412.1 (M+H);

4-(2H-benzo[b][1,4]oxazin-3(4H)-on-6-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5-15 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #124, 1H NMR (CD3OD, 300 MHz): δ 8.36 (m, 1H), 7.75 (m, 3H), 7.33-6.77 (m, 4H), 4.63 (s, 2H), 4.59 (s, 1H), 4.31 (s, 1H), 3.92 (m, 2H), 3.41 (m, 1H), 3.15 (m, 1H), 2.97 (s, 3H), 2.33 (m, 2H); MS (ES) 447.09 (M+H); 4-(2,2,4-trimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-/\/-(3-methyl-4-20 ((1S,4S)-5-methyi-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #125,1H NMR (CD3OD, 300 MHz) 8.80 (m, 1H), 8.39 (m, 1H), 8.01 (m, 2H), 7.55 (m, 2H), 7.26 (m, 1H), 6.98 (m, 1H), 4.63 (s, 1H), 4.31 (s, 1H), 4.25 (s, 1H), 3.50 (m, 4H), 3.28 (m, 2H), 2.99 (s, 3H), 2.32 (m, 5H), 1.54 (m, 6H); MS (ES) 486.21 (M+H); 25 4-(2,2,4-trimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-5][1,4]oxazin-7-yl)-N-(3-fluoro-4- ((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #126, 1H NMR (CD3OD, 300 MHz): δ 8.75 (m, 1H), 8.39 (m, 2H), 7.96 (m, 1H), 7.65 (m, 1H), 7.25 (m, 2H), 6.79 (m, 1H), 4.57 (s, 1H), 4.29 (s, 1H), 3.84 (m, 2H), 3.48 (m, 5H), 3.30 (m, 6H), 2.94 (m, 3H), 2.30 (m, 2H); MS (ES) 490.19 30 (M+H); 4-(5-(3-methyipiperidin-1-yl)pyrazin-2-yl)-N-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrirnidin-2-amine, compound #127,1H NMR (CD3OD, 300 MHz): δ 9.00 (m, 1H), 8.31 (m, 2H), 7.57 (m, 2H), 7.31 (m, 1H), 6.85 (m, 1H), 4.64 (s, 1H), 4.45 (m, 2H), 4.33 (s, 1H), 4.29 (s, 1H), 3.96 (m, 199 200 2H), 3.45 (m, 1 Η), 3.19 (m, 1H), 3.07 (m, 1H), 2.98 (s, 3H), 2.74 (m. 2H), 2.35 (m, 2H), 1.19-1.26 (m, 4H), 1.00 (d, J= 5.4 Hz, 3H); MS (ES) 475.48 (M+H); 4-(4-(/-butylcarbonylamino)phenyl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine, compound #128,1H 5 NMR (CD3OD, 300 MHz): δ 8.42 (m, 2H), 8.10 (m, 2H), 7.75 (m, 3H), 7.25 (m, 2H), 4.57 (s, 1H), 4.26 (s, 1H), 3.81 (m, 2H), 3.46 (m, 2H), 2.93 (s, 3H), 2.29 (m, 2H), 1.34 (s, 9H); MS (ES) 475.12 (M+H); 4-(4-(i-butylcarbonylamino)phenyl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #129,1H 10 NMR (CD3OD, 300 MHz): δ 8.34 (m, 2H), 8.10 (m, 2H), 7.72 (m, 2H), 7.51 (m, 2H), 7.22 (m, 1H), 6.95 (m, 1H), 4.29 (s, 1H), 4.22 (s, 1H), 3.76 (m, 2H), 3.47 (m, 2H), 2.97 (m, 3H), 2.31 (m, 5H), 1.32 (s, 9H); MS (ES) 471.15 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/-/-pyrido[3,2-d][1,4]oxazin-7-yl)-A/-(3-methyl-4- ((1S,4$)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, 15 compound #130, 1H NMR (CD3OD, 300 MHz); δ 8.68 (m, 1H), 8.48 (m, 1H), 8.39 (m, 1H), 7.49 (m, 2H), 7.27 (m, 1H), 6.96 (m, 1H), 4.23 (m, 2H), 3.72 (m, 1H), 3.50 (m, 2H), 3.26 (m, 1H), 2.95 (s, 3H), 2.66 (m, 1H), 2.32 (s, 3H), 2.30 (m, 2H), 1.54 (s, 6H); MS (ES) 472.22 (M+H); 4-(6-(acetamido)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-

20 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #132,1H NMR (CD3OD, 300 MHz): δ 9.02 (m, 1H), 8.42 (m, 2H), 8.21 (m, 2H), 7.52 (m, 2H), 7.23 (m, 1H), 6.97 (m, 1H), 4.29 (s, 1H), 4.30 (s, 1H), 4.24 (s, 1H), 3.77 (m, 1H), 3.52 (m, 2H), 2.97 (s, 3H), 2.31 (m, 5H), 2.21 (s, 3H); MS (ES) 430.07 (M+H); 25 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #133,1H NMR (CD3OD, 300 MHz): δ 8.50-8.15 (m, 6H), 8.00 (m, 1H), 7.73 (m, 1H), 7.39 (m, 4H), 6.83 (m, 1H), 4.61 (s, 1H), 4.32 (s, 1H), 3.92 (m, 3H), 3.44 (m, 1H), 3.18 (m, 1H), 2.97 (s, 3H), 2.37 (m, 2H); MS (ES) 496.05 (M+H); 30 4-(4-((pyridin-2-yl)aminocarbonyl)phenyi)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #134,1H NMR (CD3OD, 300 MHz): δ 8.45-7.96 (m, 8H), 7.50 (m, 4H), 6.99 (m, 1H), 4.61 (s, 1H), 4.30 (m, 2H), 3.98 (m, 1H), 3.50 (m, 2H), 3.15 (m, 1H), 2.99 (s, 3H), 2.33 (m, 5H); MS (ES) 492.08 (M+H); 200 201 4-(4-(methylsulfonylamino)pheny1)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #135,1H NMR (CD3OD, 300 MHz): δ 8.36 (m, 1H), 8.13 (m, 2H), 7.65 (m, 2H), 7.32 (m, 3H), 6.83 (m, 1H), 4.62 (s, 1H), 4.32 (s, 1H), 3.92 (m, 2H), 3.39 (m, 1H), 3.20 (m, 5 1H), 3.05 (s, 3H), 2.97 (s, 3H), 2.34 (m, 2H); MS (ES) 469.03 (M+H); 4-(4-(methylsulfonylamino)phenyl)-/\/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #136,1H NMR (CD3OD, 300 MHz): δ 8.21 (m, 3H), 7.39 (m, 5H), 7.01 (m, 1H), 4.34 (m, 2H), 3.99 (m, 1H), 3.77 (m, 1H), 3.53 (m, 2H), 3.20 (m, 1H), 3.07 (s, 3H), 2.99 (s, 10 3H), 2.66 (m, 1H), 2.33 (m, 5H); MS (ES) 465.05 (M+H); 4-(2,2-dimethyi-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #137, 1H NMR (CD3OD, 300 MHz): δ 8.67 (m, 1H), 8.48 (m, 1H), 8.39 (m, 2H), 7.98 (m, 1H), 7.54 (m, 2H), 7.20 (m, 1H), 6.69 (m, 2H), 4.63 (s, 1H), 4.33 (s, 1H), 15 3.72 (m, 2H), 3.37 (m, 1H), 3.24 (m, 1H), 2.93 (s, 3H), 2.34 (s, 2H), 1.54 (s, 6H); MS (ES) 458.21 (M+H); 4-(4-(3-cyclopropylureido)phenyl)-A/-(4-((1S,4S)-5-methyl-2,5-diazabicycio[2.2.1]heptan-2-yl)pbenyl)pyrimidin-2-arnine, compound #139,1H NMR (CD3OD, 300 MHz): δ 8.28 (m, 1H), 8.18 (m, 1Ηξ 8.03 (m, 2H), 7.55 (m, 3H), 7.13 (m, 2H), 6.69 (m, 20 2H), 4.64 (s, 1H), 4.35 (s, 1H), 3.77 (m, 2H), 3.36 (m, 2H), 2.95 (s, 3H), 2.61 (m, 1H), 2.35 (m, 3H), 0.76 (m, 1H), 0.53 (m, 3H); MS (ES) 456.52 (M+H); 4-(6-(2-(morphol!n-4-yl)acetamido)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #141,1H NMR (CD3OD, 300 MHz): δ 9.10 (m, 1H), 8.51 (m, 2H), 8.39 (m, 1H), 7.49 (m, 25 2H), 7.31 (m, 1H), 6.99 (m, 1H), 4.28 (m, 4H), 3.97 (m, 6H), 3.48 (m, 4H), 3.34 (m, 1H), 3.21 (m, 1H), 2.99 (s, 3H), 2.32 (m, 6H); MS (ES) 515.72 (M+H); 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yi)-N-(4-((1S,4S)-5-methy!-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #142,1H NMR (CD3OD, 300 MHz): δ 9.10 (m, 1H), 8.51 (m, 1H), 8.36 (m, 2H), 7.52 (m, 30 2H), 7.32 (m, 1H), 6.73 (m, 1H), 4.66 (s, 1H), 4.36 (s, 1H), 4.26 (s, 1H), 4.12-3.78 (m, 6H), 3.46 (m, 4H), 3.21 (m, 2H), 2.97 (s, 3H), 2.33 (m, 3H); MS (ES) 501.06 (M+H);

4-(6-(2-(morpholin-4-y))acetamido)pyridin-3-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #143,1H 201 202 NMR (CD3OD, 300 MHz): δ 9.05 (m, 1H), 8.51 (m, 1H), 8.24 (m, 2H), 7.66 (m, 1H), 7.29 (m, 2H), 6.80 (m, 1H), 4.66 (s, 1H), 4.59 (m, 1H), 4.31 (s, 1H), 3.80 (m, 6H), 3.50 (m, 1H), 3.26 (m, 2H), 2.96 ($, 3H), 2.64 (m, 4H), 2.32 (m, 3H); MS (ES) 519.06 (M+H); 5 4-(6-(acetamido)pyridin-3-yl)-A/-(3-methyl-4-((1S,4$)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #147,1H NMR (CD3OD, 300 MHz): δ 9.03 (m, 1H), 8.42 (m, 2H), 8.22 (m, 2H), 7.41 (m, 1H), 7.20 (m, 1H), 6.88 (m, 1H), 4.58 (s, 1H), 4.17 (s, 1H), 4.05 (m, 1H), 3.82 (m, 1H), 3.23 (m, 2H), 2.28 (m, 3H), 2.21 (s, 3H), 2.03 (m, 1H), 1.91 (m, 1H); MS (ES) 416.97 (M+H); 10 4-(6-aminopyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-ethylcarbonyl-2l5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #148,1H NMR (CD3OD, 300 MHz): δ 8.65 (m, 1H), 8.38 (m, 2H), 8.06 (m, 1H), 7.40 (m, 2H), 7.14 (m, 1H), 6.89 (m, 1H), 4.65 (s, 1H), 4.23 (s, 1H), 4.19 (m, 1H), 3.70- 3.36 (m, 3H), 2.65 (s, 3H), 2.44 (m, 2H), 2.37 (s, 3H), 2.14-1.89 (m, 2H), 1.14 (m, 15 2H); MS (ES) 430.02 (M+H); 4-(6-(acetamido)pyridin-3-yl)-/\/-(3-methyl-4-((1S,4S)-5-ethylcarbonyl-2,5- dfazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #149,1H NMR (CD3OD, 300 MHz): δ 9.03 (m, 1H), 8.39 (m, 2H), 8.22 (m, 2H), 7.42 (m, 2H), 7.21 (m, 1H), 6.91 (m, 1H), 4.65 (s, 1H), 4.25 (s, 1H), 3.68-3.32 (m, 5H),

20 2.66-2.32 (m, 2H), 2.29 (s, 3H), 2.21 (s, 3H), 2.08-1.82 (m, 2H), 1.14 (m, 2H); MS (ES) 472.06 (M+H); 4-(6-aminopyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methylsulfonyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #150,1H NMR (CD3OD, 300 MHz): δ 8.68 (m, 1H), 8.28 (m, 2H), 8.09 (m, 1H), 7.41 (m, 25 2H), 7.09 (m, 1H), 6.75 (m, 1H), 4.65 (s, 1H), 4.20 (m, 1H), 4.19 (m, 1H), 3.71- 3.39 (m, 3H), 2.66-2.39 (m, 2H), 2.29 (s, 3H), 2.21 (s, 3H), 2.13-1.88 (m, 2H), 1.14 (m, 2H); MS (ES) 451.99 (M+H); 4-(6-(methyisulfonylamino)pyridin-3-yl)-/V-(3-methyl-4-((1Sl4S)-5-rnethyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #151, 1H 30 NMR (CD3OD, 300 MHz): δ 8.96 (m, 1H), 8.43 (m, 1H), 8.30 (m, 1H), 7.54 (m, 2H), 7.23 (m, 1H), 7.15 (m, 1H), 6.97 (m, 1H), 4.30 (s, 1H), 4.25 (s, 1H), 3.80- 3.37 (m, 3H), 3.23 (m, 2H), 2.98 (s, 3H), 2.66 (m, 2H), 2.32 (brs, 6H); MS (ES) 466.03 (M+H); 4-(6-(2-(dimethylamino)acetamido)-pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2I5- 202 203 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #152,1H NMR (CD3OD, 300 MHz): δ 8.52 (m, 1H), 8.31 (m, 1H), 8.20 (m, 1H), 7.52 (m, 2H), 7.21 (m, 2H), 6.96 (m, 1H), 4.31 (s, 1H), 4.24 (s, 1H), 3.91-3.48 (m, 5H), 2.99 (s, 3H), 2.83 (s, 3H), 2.65 (s, 3H), 2.32 (m, 6H); MS (ES) 473.04 (M+H); 4-(6-(methyisulfonylamino)pyridin-3-yl)-A/-(3-fluoro-4-((1S,4S)-5-methy!-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrirnidin-2-amine, compound #153,1H NMR (CD3OD, 300 MHz): δ 8.94 (m, 1H), 8.39 (m, 3H), 7.62 (m, 1H), 7.22 (m, 3H), 6.78 (m, 1H), 4.56 (s, 1H), 4.29 (s, 1H), 3.79-3.43 (m, 5H), 2.93 (m, 2H), 2.66 (m, 1H), 2.30 (m, 3H); MS (ES) 469.99 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3- yl)phenyl)pyrimidin-2-amine, compound #155, 1H NMR (CD3OD, 300 MHz): δ 8.90 (m, 1H), 8.49 (m, 1H), 8.25 (m, 2H), 7.59 (m, 2H), 7.13 (m, 1H), 6.94 (m, 1H), 6.87 (m, 1H), 3.93 (m, 2H), 3.78 (m, 4H), 3.61 (m, 6H), 3.13 (m, 2H), 2.81 (s, 3H), 2.19 (m, 4H); MS (ES) 458.03 (M+H); 4-(6-(methylsulfonylamino)pyrid!n-3-yl)-N-(4-(8-methyl-3,8-diazabicyclo[3.2.1joctan-3-yl)phenyl)pyrimidin-2-amine, compound #156,1H NMR (CD3OD, 300 MHz): δ 8.90 (m, 1H), 8.36 (m, 3H), 7.75 (m, 1H), 7.56 (m, 2H), 7.13 (m, 2H), 6.91 (m, 2H), 3.97 (m, 2H), 3.72 (m, 2H), 3.19 (m, 2H), 2.83 (s, 3H), 2.25 (m, 5H); MS (ES) 466.03 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)pyrimidin-2-amine, compound #157,1H NMR (CD3OD, 300 MHz): δ 8.67 (m, 1H), 8.38 (m, 1H), 7.99 (m, 1H), 7.59 (m, 2H), 7.21 (m, 1H), 6.95 (m, 2H), 3.97 (m, 2H), 3.68 (m, 2H), 3.17 (m, 3H), 2.85 (s, 3H), 2.65 (m, 1H), 2.22 (m, 4H), 1.55 (s, 6H); MS (ES) 472.09 (M+H); 4-(6-aminopyridin-3-yi)-A/-(4-(8-methyi-3,8-diazabicyclo[3.2.1]octan-3- y!)phenyl)pyrimidin-2-amtne, compound #158, 1H NMR (CD3OD, 300 MHz): δ 8.87 (m, 1H), 8.28 (m, 2H), 8.15 (m, 1H), 7.58 (m, 2H), 7.09 (m, 1H), 6.93 (m, 2H), 6.65 (m, 1H), 4.03 (m, 2H), 3.68 (m, 2H), 3.25 (m, 3H), 2.89 (s, 3H), 2.64 (m, 1H), 2.23 (m, 4H); MS (ES) 388.04 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-(1,4-diazabicyclo[3.2.2]nonan-4- yl)phenyl)pyrimidin-2-amine, compound #159,1H NMR (CD3OD, 300 MHz): δ 8.27 (m, 3H), 7.51 (m, 2H), 7.15 (m, 2H), 6.86 (m, 1H), 3.80 (m, 4H), 3.60 (m, 7H), 3.46 (m, 4H), 3.30 (m, 2H), 2.41 (m, 2H), 2.35 (s, 3H), 2.07 (m, 2H); MS (ES) 472.12 (M+H); 203 204 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4Joxazin-7-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2,2]nonan-4-yl)phenyl)pyrimidin-2-amine, compound #160,1H NMR (CD3OD, 300 MHz): δ 8.64 (m, 1H), 8.47 (m, 1H), 8.38 (m, 1H), 7.95 (m, 1H), 7.51 (m, 2H), 7.14 (m, 2H), 3.51-3.43 (m, 9H), 2.40 (m, 2H), 2.34 (s, 3H), 2.34 (m, 2H), 1.54 (s, 6H); MS (ES) 486.11 (M+H); 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-A/-(3-methyl-4-(1,4-diazabicyc!o[3.2.2]nonan-4- yl)phenyl)pyrimidin-2-amine, compound #161,1H NMR (CD3OD, 300 MHz): δ 8.47-8.22 (m, 4H), 8.10 (m, 3H), 7.84 (m, 1H), 7.60 (m, 2H), 7.35-7.15 (m, 3H), 3.61-3.48 (m, 9H), 2.44 (m, 2H), 2.37 (s, 3H), 2.12 (m, 2H); MS (ES) 506.06 (M+H); 4-(4-(acetamido)phenyl)-/\/-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3- yl)phenyl)pyrimidin-2-amine, compound #162,1H NMR (CD3OD, 300 MHz): δ 8.34 (m, 1H), 8.10 (m, 2H), 7.66 (m, 4H), 7.19 (m, 1H), 6.95 (m, 2H), 3.99 (m, 2H), 3.68 (m, 2H), 3.13 (m, 2H), 2.86 (s, 3H), 2.23 (m, 4H), 2.16 (s, 3H); MS (ES) 429.32 (M+H); 4-(2-(diethylamino)thiazol-4-yl)-N-(3-methyl-4-((1$,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #163,1H NMR (CD3OD, 300 MHz): δ 8.37 (m, 1H), 7.53 (m, 1H), 7.46 (m, 2H), 7.29 (m, 1H), 6.95 (m, 1H), 4.31 (s, 1H), 4.23 (s, 1H), 3.56 (m, 6H), 2.99 (s, 3H), 2.31 (brs, 5H), 1.27 (m, 8H); MS (ES) 450.30 (M+H); 4-(2-(diethylamino)thiazol-4-yl)-N-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #164,1H NMR (CD3OD, 300 MHz): δ 8.47 (m, 1H), 8.38 (m, 1H), 7.70 (m, 1H), 7.45 (m, 1H), 7.29 (m, 2H), 6.77 (m, 1H), 4.54 (s, 1H), 4.23 (s, 1H), 3.60 (m, 5H), 3.03 (m, 1H), 2.91 (s, 3H), 2.29 (m, 2H), 1.27 (m, 8H); MS (ES) 454.00 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.13octan-3-yl)phenyl)pyrimidin-2-amine, compound #165, 1H NMR (CDgOD, 300 MHz): δ 8.70 (m, 1H), 8.42 (m, 1H), 8.01 (m, 1H), 7.56 (m, 2H), 7.27 (m, 3H), 4.01 (brs, 2H), 3.25-3.10 (m, 3H), 2.89 (s, 3H), 2.41 (s, 3H), 2.31 (m, 5H), 1.55 (s, 6H); MS (ES) 486.08 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(8-methy!-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyi)pyrimidin-2-amine, compound #166,1H NMR (CD3OD, 300 MHz): δ 8.88 (m, 1H), 8.42 (m, 1H), 8.31 (m, 1H), 7.48 (m, 2H), 7.35 (m, 1H), 7.21 (m, 2H), 4.03 (brs, 2H), 3.85-3.74 (m, 7H), 3.34 (m, 1H), 3.12 (m, 2H), 2.89 (s, 3H), 204 205 2.67 (s, 3H), 2.40 (m, 6H); MS (ES) 472.13 (M+H); 4-(6-(methyisulfonylamino)pyridin-3-yl)-/V-(3-methyl-4-(8-methyl-3,8- diazabicycloi3.2.1]octan-3-yl)phenyl)pyrimidin-2-amine, compound #167,1H NMR (CD3OD, 300 MHz): δ 8.39 (m, 1H), 8.15 (m, 2H), 7.56 (m, 2H), 7.34 (m, 2H), 7.26 (m, 2H), 7.16 (m, 2H), 4.01 (brs, 2H), 3.44-3.10 (m, 3H), 3.24 (m, 1H), 3.05 (s, 3H), 2.89 (s, 3H), 2.28 (m, 6H); MS (ES) 479.08 (M+H); 4-(4-(f-butylcarbonylamino)phenyl)-N-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1]octan- 3- yi)phenyl)pyrimidin-2-amine, compound #168,1H NMR (CD3OD, 300 MHz): δ 8.33 (m, 1H), 8.15 (m, 2H), 7.78 (m, 2H), 7.54 (m, 2H), 7.41 (m, 1H), 7.20 (m, 1H), 4.02 (brs, 2H), 3.30-3.08 (m, 3H), 3.08 (s, 3H), 2.66 (s, 3H), 2.40 (m, 5H), 1.32 (s, 9H); MS (ES) 485.62 (M+H); 4-(1 H-pyrrol-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #169,1H NMR (CD3OD, 300 MHz): δ 8.27 (m, 1H), 8.17 (m, 1H), 7.51 (m, 3H), 6.94 (m, 2H), 4.30 (s, 1H), 4.22 (s, 1H), 3.76 (m, 1H), 3.46 (m, 2H), 3.29 (s, 3H), 2.97 (s, 3H), 2.31 (m, 4H); MS (ES) 361.07 (M+H); 4-(1 H-pyrrol-3-yl)-A/-(4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2- yl)phenyl)pyrimidin-2-amine, compound #170, e1H NMR (CD3OD, 300 MHz): δ 8.10 (m, 1H), 7.52 (m, 3H), 6.93 (m, 2H), 6.80 (m, 1H), 6.70 (m, 2H), 4.63 (s, 1H), 4.35 (s, 1H), 3.75 (m, 2H), 3.34 (m, 2H), 2.95 (s, 3H), 2.34 (m, 2H); MS (ES) 347.04 (M+H); 4-(1 H-pyrrol-3-yl)-A/-(3-trifluoromethyl-4-((1 S,4S)-5-methyl-2,5-diazabicyc!o[2,2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #171,1H NMR (CD3OD, 300 MHz): δ 8.41 (m, 2H), 8.23 (m, 1H), 7.82 (m, 1H), 7.55 (s, 1H), 7.38 (m, 1H), 6.99 (m, 1H), 6.81 (m, 1H), 6.73 (m, 1H), 4.33 (s, 1H), 4.03 (s, 1H), 3.70 (m, 3H), 3.24 (m, 2H), 2.97 (s, 3H), 2.34 (m, 2H); MS (ES) 415.04 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2B-pyrido[3,2-b][1,4]oxazin-7-yl)-/\/-(3-trifluoromethyl- 4- ((1S,4S)-2,5-diazabicyclo[2,2.1]heptan-2-yi)phenyl)pyrimidin-2-amine, compound #172, 1H NMR (CD3OD, 300 MHz): δ 8.69 (m, 1H), 8.48 (m, 2H), 8.31 (m, 1H), 8.03 (m, 1H), 7.86 (m, 1H), 7.33 (m, 2H), 4.33 (s, 1H), 4.08 (s, 1H), 3.65- 3.55 (m, 3H), 3.22 (m, 1H), 2.97 (s, 3H), 2.34 (m, 2H), 1.55 (s, 6H); MS (ES) 526.11 (M+H); 4-(6-ethoxypyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #173,1H NMR (DMSO-de): δ 9.30 (s, 205 206 1 Η), 8.92 ($, 1 Η), 8.42 (d, 1 Η, J = 4.3 Hz), 8.37 (dd, 1H, J = 2.3 and 8.8 Hz), 7.47 (d, 1H, J = 8.8 Hz), 7.42 (s, 1H), 7.28 ( d, 1H, J = 4.9 Hz), 6.93 (d, 1H, J = 8.5

Hz), 6.74 (d, 1H, J = 8.5 Hz), 4.36 (qt, 2H, J = 7.0 Hz), 3.88 (s, 1H), 3.17 (app qt, 2H, 7 = 9.1 Hz), 2.73 (d, 1H, 7 = 9.0 Hz), 2.66 (d, 1H, 7 = 9.0 Hz), 2.25 (s, 3H), 5 2.18(s,3H), 1.77 (d, 1H,7 = 9.0Hz), 1.68 (d, 1H,7 = 9.0Hz), 1.32 (t, 3H, 7 = 7.0

Hz); LCMS: purity: 99%; MS (m/e): 417 (MH+); 4-(6-ethoxypyridin-3-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #174, LCMS: purity: 99%; MS (m/e): 421 (MH+); 10 4-(2-(dimethylamino)thiazol-4-yl)-/V-(3-methyl-4-((1S,4S)-5-rnethyl-2,5- diazabicyclo[2.2.1]heptan-2-y!)phenyl)pyrimidin-2-amine, compound #175,1H NMR (DMSO-d6): δ 9.24 (s, 1H). 8.43 (d, 1H, 7 = 4.9 Hz), 7.53 (d, 1H, 7 = 16.7 Hz), 7.51 (m, 1H), 7.44 (s, 1H), 7.19( d, 1H, 7 = 4.9 Hz), 6.76 (d, 1H, 7 = 8.5 Hz), 3.90 (s, 1H), 3.42 (s, 1H), 3.19 (app qt, 2H, 7 = 9.1 Hz), 3.08 (s, 6H), 2.78 (s, 2H), 15 2.34 (s, 3H), 2.18 (s, 3H), 1.83 (d, 1H, 7 = 9.0 Hz), 1.73 (d, 1H, 7 = 9.0 Hz); LCMS: purity: 99%; MS (m/e): 422 (MH+); 4-(2-(dimethylamino)thiazol-4-yl)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #176,1H NMR (DMSO-d6): δ 9.43 (s, 1H), 8.45 (d, 1H, 7 = 4.9 Hz), 7.53 (d, 1H, 7 = 16.7 20 Hz), 7.51 (m, 1H), 7.38 (d, 1H, 7 = 7.3 Hz), 7.21 (d,1 H, 7 = 4.9 Hz), 6.68 (t, 1H, 7 = 9.1 Hz), 4.14 (s, 1H), 3.39 (d, 1H, 7 = 9.3 Hz), 3.16 (d, 1H, 7 = 9.3 Hz), 3.08 (s, 6H), 2.72 (d, 1H, 7 = 9.0 Hz), 2.59 (d, 1H, 7 = 9.0 Hz), 2.23 (s, 3H), 1.79 (d, 1H, 7 = 9.0 Hz), 1.69 (d, 1H, 7= 9.0 Hz); LCMS: purity: 99%; MS (m/e): 426 (MH+); 4-(5-(morpholtn-4-yl)pyrazin-2-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-

25 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #178, 1H NMR (DMSO-ck): δ 9.27 (s, 1H), 8.98 (s, 1H), 8.43 (d, 1H, 7 = 4.9 Hz), 8.40 (s, 1H), 7.49 (d, 1H, 7 = 8.8 Hz), 7.42 (s, 1H), 7.36 (d, 1H, 7 = 4.9 Hz), 6.75 (d, 1H, 7 = 8.8 Hz), 3.88 (s, 1H), 3.69-3.67 (m, 8H), 3.17 (app qt, 2H, 7 = 9.1 Hz), 2.73 (d, 1H, 7 = 9.1 Hz), 2.66 (d,1H, 7=9.1 Hz), 2.25 (s, 3H), 2.19 (s, 3H), 1.76 (d, 1H, 7 30 = 8.8 Hz), 1.69 (d, 1H, 7 = 8.8 Hz); LCMS: purity: 90%; MS (m/e): 459 (MH+); 4-(5-(morpholin-4-yl)pyrazin-2-yl)~A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #179,3H NMR (DMSO-de): δ 9.48 (s, 1H), 8.98 (s, 1H), 8.47 (d, 1H, 7 = 4.9 Hz), 8.42 (s, 1H), 7.64 (d, 1H, 7= 16.7 Hz), 7.40-7.34 (m, 2H), 6.71 (d, 1H, 7 = 9.1 Hz), 4.16 206 207 (s, 1H), 3.69-3.68 (m, 8H), 3.39 (d, 1H, J = 9.6 Hz), 3.17 (d, 1H, 7= 9.6 Hz), 2.72 (d, 1H, 7=9.1 Hz),2.59 (d, 1H, 7=9.1 Hz), 2.22 (s, 3H), 1.79 (d, 1H, J =8.8 Hz), 1.69 (d, 1H, 7= 8.8 Hz); LCMS: purity: 99%; MS (m/e): 463 (MH+); 4-(4-( 1-ethoxyethyl)phenyl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- 5 diazabicyclo[2.2.1 ]heptan-2-yl)phenyi)pyrimidin-2-amine, compound #181, LCMS: purity: 99%; MS (m/e); 444 (MH+); 4-(4-(1-ethoxyethyl)phenyl)-/V-(3-fluoro-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #182, LCMS; purity: 99%; MS (m/e): 447 (MH+); 10 4-(6-(dimethyiamino)pyridin-3-yi)-/V-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #183,1H NMR (DMSO-c/6): δ 9.09 (s, 1H), 8.87 (s, 1H), 8.29 (d, 1H, J = 4.9 Hz), 8.19 (d, 1H, J = 8.8 Hz), 7.53 (d, 2H, J = 8.5 Hz), 7.14 (d, 1H, J= 5.3 Hz), 6.73 (d, 1H, J= 9.1 Hz), 6.53 (d, 2H, J= 8.5 Hz), 4.21 (s, 1H), 3.35 (s, 1H), 3.26 (s, 1H), 3.09-3,04 (m, 7H), 2.73 (d, 1H, 7 = 15 9.6 Hz), 2.21 (s, 3H), 1.82 (d, 1H, J = 8.8 Hz), 1.73 (d, 1H, J = 8.8 Hz); LCMS; purity; 99%; MS (m/e): 402 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(4-((1S,4S)-5-methyl-2,5-diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #184,1H NMR (DMSO-ds): δ 9.13 (s, 1H), 8.90 (d, 1H, J = 2.0 Hz), 8.33 (d, 1H, J = 4.7 Hz), 8.24 (dd, 1H, J = 2.0 and 20 8.8 Hz), 7.52 (d, 2H, J = 8.8 Hz), 7.18 (d, 1H, J = 4.7 Hz), 6.94 (d, 1H, J = 8.8

Hz), 6.53 (d, 2H, J = 8.8 Hz), 4.20 (s, 1H), 3.69-3.67 (m, 4H), 3.56 (brs, 4H), 3.35 (s, 1H), 3.27 (s, 1H), 3.09 (d, 1H, J = 8.8 Hz), 2.73 (d, 1H, J = 8.8 Hz), 2.21 (s, 3H), 1.82 (d, 1H, J = 8.8 Hz), 1.73 (d, 1H, J = 8.8 Hz); LCMS: purity: 99%; MS (m/e): 444 (MH+); 25 4-(4-methyl-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #185,1H NMR (DMSO-de): δ 9.08 (s, 1H), 8.49 (d, 1H, J = 1.8 Hz), 8.28 (d, 1H, J = 4.9 Hz), 7.58 (d, 1H, J = 1.8 Hz), 7.49 (d, 2H, J = 8.8 Hz), 7.14 (d, 1H, J = 4.9 Hz), 6.53 (d, 2H, 7= 8.8 Hz), 4.21 (s, 3H), 3.51-3.50 (m, 2H), 3.35 (s, 1H), 3.26 (s, 1H), 30 3.10 (s, 3H), 3.06 (d, 1H, 7= 8.8 Hz), 2.73 (d, 1H, 7= 8.8 Hz), 2.21 (s, 3H), 1.82 (d, 1H, 7 = 9.1 Hz), 1.72 (d, 1H, 7= 9.1 Hz; LCMS: purity: 99%; MS (m/e); 430 (MH+); 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methy 1-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #186, LCMS: 35 purity: 99%; MS (m/e): 474 (MH+); 207 208 4-(6-(c/s-2,6-dimethylmorpho!in-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #187,1H NMR (DMSO-d6): δ 9.20 (s, 1H), 8.89 (d, 1H, J = 2.3 Hz), 8.34 (d, 1H, J = 5.3 Hz), 8.24 (dd, 1H, J= 2.3 and 9.1 Hz), 7.48 (d, 1H, J = 9.1 Hz), 7.44 (s, 1H), 7.21 (d, 1H, J = 5.3 Hz), 6.97 (d, 1H, 7=9.1 Hz), 6.74 (d, 1H, 7 = 9.1 Hz), 4.30-4.26 (m, 2H), 3.88 (s, 1H), 3.61-3.56 (m, 2H), 3.21-3.13 (m, 2H), 2.73 (app qt, 2H, 7 = 9.1 Hz), 2.27 (s, 3H), 2.18 (s, 3H), 1.77 (d, 1H,7 = 9.0 Hz), 1.68 (d, 1H, 7= 9.0 Hz), 1.15 (d, 6H, 7 = 6.2 Hz); LCMS: purity; 99%; MS (m/e): 486 (MH*); 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #188,1H NMR (DMSO-d6): δ 9.14 (s, 1H), 8.78 (s, 1H), 8.30 (d, 1H, 7 = 5.3 Hz), 8.06 (d, 1H, 7= 8.8 Hz), 7.49 (d, 1H, 7= 8.5 Hz), 7.43 (s, 1H), 7.13-7.12 (m, 2H), , 6.75 (d, 1H, 7= 8.8 Hz), 6.54 (d, 1H, 7 = 8.8 Hz), 3.89 (s, 1H), 3.28-3.14 (m, 5H), 2.76-2.79 (m, 2H), 2.29 (s, 3H), 2.18 (s, 3H), 1.79 (d, 1H, 7 = 9.1 Hz), 1.69 (d, 1H, 7 = 9.1 Hz), 1.60-1.48 (m, 2H), 0.90 (t, 3H, 7 = 7.3 Hz); LCMS: purity: 99%; MS (m/e): 430 (MH*); 4-(6-(2-(dimethylamino)methylmorpholin-4-yl)pyridin-3-yl)-/\/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #189, 1H NMR (DMSO-76): δ 9.20 (s, 1H), 8.90 (s, 1H), 8.35 (d, 1H, 7 = 4.9 Hz), 8.25 (appd, 1H, 7 = 8.8 Hz), 7.48 (d, 1H, 7 = 8.5 Hz), 7.43 (s, 1H), 7.21 (d, 1H, J = 4.9 Hz), 6.94 (d, 1H, 7= 8.5 Hz), 6.74 (d, 1H, 7 = 8.8 Hz), 4.34 (d, 1H, 7= 12.4 Hz), 4.14 (d, 1H, 7= 12.4 Hz), 3.94-2.88 (m, 2H), 3.57-3.49 (m, 2H), 3.21-3.10 (m, 3H), 2.96-2.92 (m, 1H), 2.74-2.58 (m, 3H), 2.41-2.30 (m, 2H), 2.30 (s, 3H), 2.18 (overlaps, 9H), 1.77 (d, 1H, 7 = 9.1 Hz), 1.68 (d, 1H, 7=9.1 Hz); LCMS: purity: 99%; MS (m/e): 515 (MH+); 4-(6-(piperidin-1-yl)pyridin-3-yl)-N-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicyclo{2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #190,1H NMR (DMSO-de): δ 9.17 (s, 1H), 8.86 (s, 1H), 8.33 (d, 1H, 7= 5.3 Hz), 8.20-8.17 (d, 1H, 7 = 9.1 Hz), 7.49 (d, 1H, 7 = 8.8 Hz), 7.43 (s, 1H), 7.17 (d, 1H, J = 5.3 H), 6.91 (d, 1H, 7 = 8.8 Hz), 6.73 (d, 1H, J = 8.8 Hz), 3.87 (s, 1H), 3.62 (br s, 4H), 3.29 (s, 1H), 3.21-3.12 (m,2H), 2.72 (d, 1H,7 = 9.1 Hz), 2.66 (d, 1H, 7 = 9.1 Hz), 2.26 (s, 3H), 2.18 (s, 3H), 1.77-1.52 (m, 8H); LCMS: purity: 99%; MS (m/e): 456 (MH+); 4-(6-(3-(aminocarbonyl)piperidin-1-yl)pyridin-3-yl)-/\/-(3-methyl-4-((1$,4S)-5-methyl-2l5- 208 209 diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #191, LCMS: purity: 99%; MS (m/e): 499 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1$,4$)-5-methylsulfonyl-2,5- diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #192,1H NMR (DMSO-d6): δ 9.48 (s, 1H), 8.92 (s, 1H), 8.35 (s, 1H), 8.29 (d, 1H, J = 8.8 Hz), 7.47 (apps , 2H), 7.28 (s, 1H), 7.01 (d, 1H,7=9.1 Hz), 6.91 (d, 1H, 7=8.8 Hz), 4.35 (s, 1H), 4.18 (s, IH), 3.68 (br s, 4H), 3.60 (br s, 4H), 3.40-3.37 (m, 4H), 2.96 (s, 3H), 2.21 (s, 3H), 1.90-1.85 (m, 2H); LCMS: purity: 99%; MS (m/e): 522 (MH+); 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #193, 1H NMR (DMSO-d6): δ 9.37 (s, 1H), 8.51 (s, 1H), 8.32 (d, 1H, J = 4.3 Hz), 7.64 (s , 1H), 7.48 (s, 2H), 7.23 (d, 1H, J = 4.3 Hz), 6.89 (d, 1H, J = 8.8 Hz), 4.34 (s, 1H), 4.23-4.17 (m, 3H), 3.53 (s, 2H), 3.42-3.23 (m, 4H), 3.12 (s, 3H), 2.95 (s, 3H), 2.21 (s, 3H), 1.91 (d, 1H, J = 9.1 Hz), 1.82 (d, 1H, J =9.1 Hz); LCMS: purity: 99%; MS (m/e): 508 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #194,1H NMR (DMSO-cfe): δ 9.24 (s, 1H), 8.91 (s, 1H), 8.36 (d, 1H, 7 = 5.3 Hz), 8.25 (d, 1H, 7 = 9.1 Hz), 7.52-7.47 (m, 2H), 7.22 (d, 1H, J =5.2 Hz), 6.95 (d, 1H, J = 9.1 Hz), 6.80 (d, 1H, J = 8.5 Hz), 4.50 (s, 1H), 4.12 (s, 1H), 3.89 (d, 1H, J= 7.3 Hz), 3.69-3.67 (br m, 5H), 3,57 (br m, 5H), 3.04 (d, 1H, 7 = 9,6 Hz), 2.18 (s, 3H), 1.87 (d, 1H, J = 8.5 Hz), 1.75 (d, 1H, J= 8.5 Hz); LCMS: purity: 99%; MS (m/e): 445 (MH+); 4-(4-methyl-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)~A/-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #195,1H NMR (DMSO-c/e): δ 9.23 (s, IH), 8.51 (d, 1H, J = 1.8 Hz), 8.32 (d, 1H,7 = 5.3Hz), 7.62 (d, 1H, J = 1.8 Hz), 7.47 (s, 2H), 7.19 (d, 1H, J = 5.3 Hz), 6.81 (d, 1H, 7 = 9.1 Hz), 4.51 (s, 1H), 4.24-4.21 (m, 2H), 4.14 (s, 1H), 3.89 (d, 1H, 7 = 7.3 Hz), 3.70 (d, 1H, J =7.3 Hz), 3.53-3.50 (m, 2H), 3.33 (d, 1H, 7 = 9.1 Hz), 3.11 (s, 3H), 3.06 (d, 1H, 7 = 8.2 Hz), 2.18 (s, 3H), 1.87 (d, 1H, 7= 9.1 Hz), 1.76 (d, 1H,7 = 9.1 Hz); LCMS: purity: 99%; MS (m/e): 431 (MH+); 4-(6-(morpholin-4-yi)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-ethylcarbonyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #196,1H NMR (DMSO-76): δ 9.24 (s, 1H), 8.92 (d, 1H, 7 = 2.0 Hz), 8.36 (d, 1H, 7 = 5.3 Hz), 209 210 8.25 (dd, 1H, J = 2.3 and 9.1 Hz), 7.52-7.47 (m, 2H), 7.22 (d, 1H, J= 5.3 Hz), 6.95 (d, 1H, J = 8.8 Hz), 6.81 (app t, 1H, J = 8.8 Hz), 4.68 (s, 0.5 H), 4.55 (s, 0.5 Hz), 4.17 (s, 0.5 H), 4.11 (s, 0.5 Hz), 3.69-3.59 (m, 4H), 3.56-3.55 (m, 4H), 3.51-3.43 (m, 3H), 3.37-3.30 (m, 1H), 3.13-3.03 (m, 1H), 2.36-2.25 (m, 1H), 2.18 (s, 3H), 2.13-2.10 (m, 1H), 1.96-1.73 (m, 2H), 0.97 (t, 3H, J = 7.6 Hz); LCMS: purity: 99%; MS (m/e): 500 (MH+); 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-W-(3-methyl-4-((1S,4S)-5-ethylcarbonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #197, LCMS: purity: 99%; MS (m/e): 543 (MH+); 4-(6-(3-dimethylamino)propylaminopyridin-3-yl)-N-(3-methyl-4-((1$,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #198,1H NMR (DMSO-dg) δ 9.11 (s, 1H), 8.79 (d, 1H, J = 2.0 Hz), 8.30 (d, 1H, 7= 5.3 Hz), 8.06 (dd, 1H, 7 = 2.3 and 9.1 Hz), 7.48-7.45 (m, 2H), 7.13-7.09 (m, 2H), 6.75 (d, 1H, 7 = 8.8 Hz), 6.54 (d, 1H, 7= 8.8 Hz), 3.88 (s, 1H), 3.30 (m, 3H), 3.22-3.14 (m, 2H), 2.75-2.66 (m, 2H), 2,27-2.24 (m, 5H), 2.18 (s, 3H), 2.12 (s, 6H), 1.79-1.62 (m, 4H); LCMS: purity: 99%; MS (m/e): 473 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/\/-(3-methyl-4-((1Sl4S)-5-amidino-215- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #199, 1H NMR (DM$O-cf6): δ 9.32 (s, 1H), 8.92 (s, 1H), 8.37 (d, 1H, 7= 5.3 Hz), 8.25 (d, 1H, 7 = 9.1 Hz), 7.55 (d, 1H, 7 = 9.1 Hz), 7.51 (s, 1H), 7.31 (s, 2H), 7.24 (d, 1H,7 = 5.3 Hz), 7.17 (br s, 1H), 6.96 (d, 1H, 7 = 8.8 Hz), 6.83 (d, 1H, 7 = 8.8 Hz), 4.70 (s, 1H), 4.28 (s, 1H), 3.69-3.68 (br m, 4H), 3.57-3.56 (br m, 4H), 3.51-3.40 (m, 3H), 3.17 (d, 1H, 7 = 9.3 Hz), 2.20 (s, 3H), 2.06-1.93 (m, 2H); LCMS: purity: 92%; MS (m/e): 486 (MH+-TFA); 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-W-(3-methyl-4-((1S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine, compound #200,1H NMR (DMSO-76): δ 9.17 (s, 1H),8.80 (d, 1H,7 = 2.3 Hz), 8.31 (d, 1H,7 = 5.3Hz), 8.07 (dd, 1H, 7 = 2.3 and 8.8 Hz), 7.51 (d, 1H, 7 = 8.8 Hz), 7.46 (d, 1H, 7 = 2.0 Hz), 7.14-7.09 (m, 2H), 6.80 (d, 1H, J = 8.8 Hz), 6.54 (d, 1H, 7 = 8.8 Hz), 4.50 (s, 1H), 4.11 (s, 1H), 3.89 (d, 1H, 7= 7.3 Hz), 3.70 (d, 1H, 7= 7.3 Hz), 3.41-3.29 (m, 7H), 3.04 (d, 1H, 7= 9.3 Hz), 2.17 (s, 3H), 1.86 (d, 1H, 7= 7.3 Hz), 1.78-1.73 (m, 3H), 1.09 (t, 3H, 7 = 7.3 Hz); LCMS: purity: 99%; MS (m/e): 461 (MH+); 4-(6-c/s-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-W-(3-methyl-4-((1S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine, compound #201, LCMS: purity: 99%; MS (m/e): 473 (MH+); 210 211 4-(6-(propylamino)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine, compound #202,1H NMR (DMSO-76): δ 9.20 (s, 1H), 8.76 (s, 1H), 8.32 (d, 1H, J = 4.7 Hz), 8.11 (d, 1H, 7 = 8.8 Hz), 7.51-7.49 (m, 1H), 7.45 (s, 1H), 7.32 (m, 1H), 7.15 (s, 1H), 6.80 (d, 1H, 7= 8.8 Hz), 6.60 (d, 1H, 7 = 8.8 Hz), 4.50 (s, 1H),4.12(s, 1H), 3.89 (d, 1H, 7 = 7.3 Hz), 3.70 (d, 1H, 7 = 7.3 Hz), 3.32-3.24 (m, 3H), 3.04 (d, 1H, 7 = 8.8 Hz), 2.17 (s, 3H), 1.86 (d, 1H, 7 = 7.3 Hz), 1.76 (d, 1H, 7 = 8.8 Hz), 1.55-1.49 (m, 2H), 0.91 (t, 3H, 7 = 7.3 Hz); LCMS: purity: 99%; MS (m/e): 417 (MH+); 4-(6-(3-dimethylamino)propylaminopyridin-3-y!)-A/-(3-methyl-4-((1S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #203,1H NMR (DMSO-de): δ 9.17 (s, 1H), 8.80 (s, 1H), 8.31 (d, 1H, 7 = 5.3 Hz), 8.07 (dd, 1H, 7 = 2.3 and 9.1 Hz), 7.51 (d, 1H, 7 = 8.8 Hz), 7.46 (s, 1H), 7.14-7.13 (m, 2H), 6.80 (d, 1H, 7 = 8.5 Hz), 6.53 (d, 1H, 7 = 8.8 Hz), 4.50 (s, 1H), 4.12 (s, 1H), 3.89 (d, 1H, 7 = 7.3 Hz), 3.70 (d, 1H, 7= 7.3 Hz), 3.30-3.26 (m, 4H), 3.03 (d, 1H, 7= 8.8 Hz), 2.27 (t, 2H, 7 = 7.0 Hz), 2.17 (s, 3H), 2.11 (s, 6H), 1.87 (d, 1H, 7 = 7.3 Hz), 1.76 (d, 1H, 7 = 8.5 Hz), 1.65 (q, 2H, 7 = 7.0 Hz); LCMS: purity: 99%; MS (m/e): 460 (MH+); 4-(6-(1,4-oxazepan-4-yl)pyridin-3-yl)-N-(3-methyl-4-((1 S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #204,1H NMR (DMSO-de): δ 9.20 (s, 1H), 8.87 (d, 1H, 7 = 2.0 Hz), 8.33 (d, 1H, 7 = 5.3 Hz), 8.21 (d, 1H, 7 = 2.0 and 8.8 Hz), 7.53 (app d, 1H, 7 = 8.8 Hz), 7.45 (d, 1H, 7 = 2.0 Hz), 7.19 (d, 1H, 7= 5.3 Hz), 6.82 (d, 1H, 7= 8.8 Hz), 6.80 (d, 1H, 7= 8.8 Hz), 4.50 (s, 1H), 4.12 (s, 1H), 3.90-3.65 (m, 7H), 3.59 (t, 2H, 7= 5.8 Hz), 3.05-2.97 (m, 2H), 2.18 (s, 3H), 1.87-1.73 (m, 2H), 1.14 (t, 2H, 7 = 7.3 Hz); LCMS: purity: 99%; MS (m/e): 459 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-isobutyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #205,1H NMR (DMSO-de): δ 9.19 (s, 1H), 8.91 (s, 1H), 8.35 (d, 1H, 7 = 5.3 Hz), 8.25 (dd, 1H, 7 = 2.3 and 8.8 Hz), 7.47-7.44 (app m, 2H), 7.20 (d, 1H, 7 = 5.3 Hz), 6.95 (d, 1H, 7 = 8.8 Hz), 6.72 (d, 1H, 7 = 8.8 Hz), 3.89 (s, 1H), 3.70-3.68 (m, 4H), 3.59 - 3.57 (m, 4H), 3.36 (s, 1H), 3.21-3.14 (m, 2H), 2.80 (d, 1H, 7 = 9.1 Hz), 2.66 (d, 1H, 7 = 8.5 Hz), 2.31-2.22 (m, 2H), 2.18 (s, 3H), 1.70 (d, 1H, 7 = 8.5 Hz), 1.66 (d, 1H, 7 = 9.1 Hz), 1.56-1.52 (m, 1H), 0.83 (d, 6H, 7 = 6.4 Hz), LCMS: purity: 99%; MS (m/e): 500 (MH+); 211 212 4-(6-( 1,4-oxazepan-4-yl)pyridin-3-yl)-/V-(3-methyi-4-((1$,4S)-5-methyl-2,5-

diazabicycloi2.2.1]heptan-2-yl)phenyl)pyrimidin-2-aminel compound #206,1H NMR (DMSO-d6): δ 9.16 (s, 1H), 8.87 (d, 1H, 7= 2.0 Hz), 8.33 (d, 1H, J = 5.3 Hz), 8.22 (dd, 1H, 7= 2.3 and 9.1 Hz), 7.50 (d, 1H, 7 = 8.8 Hz), 7.42 (d, 1H, 7 = 2.3 5 Hz),7.18(d, 1H, 7 = 5.3 Hz), 6.82 (d, 1H, 7 = 8.8 Hz), 6.74 (d, 1H,7 = 8.8Hz), 3.87 (s, 1H), 3.82 -3.71 (m, 6H), 3.61-3.57 (m, 2H), 3.21-3.12 (m, 2H), 2.73 (d, 1H, 7 = 9.1 Hz), 2.66 (d, 1H, 7 = 9.1 Hz), 2.62 (s, 3H), 2.18(s, 3H), 1.91-1.83 (m, 2H), 1.76 (d, 1H, 7 = 9.1 Hz), 1.68 (d, 1H, 7=9.1 Hz); LCMS: purity: 99%; MS (m/e): 472 (MH+); 10 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-(1,5,7- trimethy!-3I7-diazabicyclo[3.3.1]nonan-3-yl)pheny!)pyrimidin-2-amine, compound #207, 1H NMR (DMSO-d6): δ 11.51 (s, 1H), 9.57 (s, 1H), 8.75 (d, 1H, 7 = 2.0 Hz), 8.50 (d, 1H, 7 = 5.3 Hz), 8.04 (d, 1H, 7 = 2.0 Hz), 7.66 (d, 1H, 7 = 2.0 Hz), 7.59 (dd, 1H,7 = 2.0 and 8.8 Hz), 7.41 (d, 1H,7=5.3 Hz),7.11 (d, 1H,7 = 8.8 Hz), 15 3.53 (d, 2H, 7 = 10.8 Hz), 3.03 (d, 2H, 7 = 10.8 Hz), 2.94-2.85 (app t, 2H, 7 = 9.9

Hz), 2.75 (s, 3H), 2.67 (d, 2H, 7= 10.8 Hz), 2.31 (s, 3H), 1.54-1.46 (m, 2H), 1.45 (s, 6H), 0.92 (s, 6H); LCMS: purity: 99%; MS (m/e): 528 (MH+); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-d][1,4]oxazin-7-yl)-/V-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine, compound 20 #208, 1H NMR (DMSO-d6): δ 11.53 (s, 1H), 9.79 (s, 1H), 8.75 (d, 1H, 7= 2.0 Hz), 8.53 (d, 1H, 7 = 5.3 Hz), 8.04 (d, 1H, 7 = 1.7 Hz), 7.85 (dd, 1H, 7 = 2.3 and 17.0 Hz), 7.46-7.41 (m, 2H), 7.09 (t, 1H, 7 = 9.1 Hz), 3.44 (d, 2H, 7 = 11.4 Hz), 3.15 (d, 2H, 7= 10.8 Hz), 2.94-2.87 (t, 2H, 7= 9.9 Hz), 2.75 (s, 3H), 2.67 (d, 2H, 7 =

10.8 Hz), 1.54-1.39 (m, 2H), 1.46 (s, 6H), 0.92 (s, 6H); LCMS: purity: 99%; MS 25 (m/e): 532 (MH+); 4-(3-oxo-3,4-dihydro-2/7-pyrido[3,2-d][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-methyi-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #209,1H NMR (DMSO-d6):811.53 (s, 1H), 9.16 (s, 1H), 8.55 (d, 1H, 7 = 2.0 Hz), 8.31 (d, 1H, 7= 5.3 Hz), 7.62 (s, 1H), 7.47-7.42 (m, 2H), 7.18 (d, 1H, 7= 5.3 Hz), 6.73 (d, 30 1H, 7 = 8.5 Hz), 4.29 (s, 2H), 3.81 (s, 1H), 3.21-3.14 (m, 3H), 2.72 (d, 1H, 7 = 9.1

Hz), 2.66 (d, 1H, 7 = 9.1 Hz), 2.26 (s, 3H), 2.19 (s, 3H), 1.76 (d, 1H, 7=9.1 Hz), 1.68 (d, 1H, 7 = 9.1 Hz); LCMS: purity: 99%; MS (m/e): 444 (MH+);

4-(3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-/\/-(3-methyl-4-((1$,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #210,1H NMR 212 213 (DMSO-c/e): δ 11.53 (s, 1H), 9.35 (s, 1H), 8.70 (d, 1H, J= 1.8 Hz), 8.45 (d, 1H, J = 5.3 Hz), 7.99 (d, 1H, J= 1.8 Hz), 7.49 (s, 1H), 7.45 (d, 1H, 7 = 8.8 Hz), 7.33 (d, 1H, 7= 5.3 Hz), 6.80 (d, 1H, 7 = 8.8 Hz), 4.72 (s, 2H), 4.50 (s, 1H), 4.13 (s, 1H), 3.89 (d, 1H, 7 = 7.3 Hz), 3.71 (d, 1H, J = 7.3 Hz), 3.04 (d, 1H, J = 9.3 Hz), 2.18 (s,

5 3H), 1.86 (d, 1H, J = 9.3 Hz), 1.75 (d, 1H, J = 9.3 Hz), LCMS: purity: 99%; MS (m/e): 431 (MH+); 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #211,1H NMR (DMSO-d6): δ 9.19 (s, 1H), 8.79 (s, 1H), 8.32 (d, 1H, 7 = 4.9 Hz), 8.08 (d, 10 1H, 7 = 2.6 and 9.1 Hz), 7.52 (d, 1H, 7 = 9.1 Hz), 7.48 (s, 1H), 7.16-7.11 (m, 2H), 6.86 (d, 1H, 7 = 8.8 Hz), 6.54 (d, 1H, 7= 8.8 Hz), 3.44-3.32 (m, 6H), 3.15-3.13 (m, 2H), 2.85 (d, 2H, J = 9.6 Hz), 2.71 (d, 2H, J = 9.6 Hz), 2.30 (s, 3H), 2.13-2.11 (m, 1H), 2.08 (s, 3H), 1.80-1.73 (m, 5H), 1.10 (t, 3H, 7 = 7.3 Hz), 0.82 (s, 6H); LCMS: purity: 99%; MS (m/e): 530 (MH*); 15 4-(6-((2S,6ft)-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #212, LCMS: purity: 99%; MS (m/e): 542 (MH+); 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7-

diazabicyclo[3.3.1jnonan-3-yl)phenyl)pyrimidin-2-amine, compound #213,1H 20 NMR (DMSO-76): δ 9.18 (s, 1H), 8.78 (s, 1H), 8.32 (d, 1H, 7= 5.3 Hz), 8.07 (dd, 1H, 7= 2.6 and 9.1 Hz), 7.54 (d, 1H, 7= 8.2 Hz), 7.48 (s, 1H), 7.16-7.11 (m, 2H), 6.86 (d, 1H, 7= 8.2 Hz), 6.54 (d, 1H, 7= 9.1 Hz), 3.26-3.24 (m, 2H), 2.85 (d, 2H, 7= 10.2 Hz), 2.70 (d, 2H, 7= 12.5 Hz), 2.30 (s, 3H), 2.08 (s, 3H), 1.76 (d, 2H, 7 = 9.6 Hz), 1.54 (q, 2H, 7 = 7.3 Hz), 1.19-1.03 (m, 2H), 0.09 (t, 3H, 7 = 7.3 Hz), 0.82 25 (s, 6H); LCMS: purity: 99%; MS (m/e): 486 (MH+); 4-(6-(3-dimethylamino)propylaminopyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicycio[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #214,1H NMR (DMSO-cfe): δ 9.18 (s, 1H), 8.78 (d,1 H, 7 = 2.3 Hz), 8.32 (d, 1H, 7 = 5.3 Hz) 8.07 (dd, 1H, 7 = 2.3 and 8.8 Hz), 7.52 (d, 1H, 7 = 8,5 Hz), 7.49 (d, 1H, 7 = 2.3 30 Hz), 7.15-7.09 (m, 2H), 6.85 (d, 1H, 7= 8.5 Hz), 6.54 (d, 1H, 7 = 8.8 Hz), 2.86 (d, 2H, 7= 10.8 Hz), 2.71 (d, 2H, 7= 10.8 Hz), 2.30 (s, 3H), 2.25-2.23 (m, 3H), 2.11 (s, 6H), 2.08 (s, 3H), 1.78 (d, 2H, 7 = 9.5 Hz), 1.68 (q, 2H, 7 = 7.3 Hz), 1.19 (d, 1H, 7 = 12.0 Hz), 1.07 (d, 1H, 7= 12.0 Hz), 0.82 (s, 6H); LCMS: purity: 99%; MS (m/e): 529 (MH+);

I i

I 213 214 4-(6-((1 S145)-2-oxa-5-azabicyclo[2.2.1 jheptan-5-yl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)- 5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pynmidin-2-amine, compound

#215, 1H NMR (DMSO-de): δ 9.16 (s, 1H), 8.87 (d, 1H, J= 2.3 Hz), 8.33 (d, 1H, J = 5.3 Hz), 8.21 (dd, 1H, J = 2.0 and 8.8 Hz), 7.49 (d, 1H, 7 = 9.1 Hz), 7.43 (d, 1H, 5 7= 5.3 Hz), 7.18 (d, 1H, 7 = 5.3 Hz), 7.74 (d, 1H, 7 = 8.8 Hz), 6.64 (d, 1H, 7 = 8.8

Hz), 4.95 (s, 1H), 4.67 (s, 1H), 3.88 (s, 1H), 3.79 (d, 1H, 7 = 6.7 Hz), 3.65 (d, 1H, 7 = 7.6 Hz), 3.50 (d, 1H, 7 = 10.3 Hz), 3.21-3.12 (m, 2H), 2.73 (d, 1H, 7 = 9.4 Hz), 2.67 (d, 1H,7 = 9.4 Hz), 2.27 (s, 3H), 2.19 (s, 3H), 1.93 (d, 1H,7=9.4 Hz), 1.87 (d, 1H, 7=9.4 Hz), 1.77 (d, 1H, 7 = 9.1 Hz), 1.68 (d, 1H, 7 = 9.1 Hz); LCMS: 10 purity: 99%; MS (m/e): 470 (MH+); 4-(6-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yi)-/\/-(3-methyl-4-((1 S,4S)- 5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #216, 1H NMR (DMSO-dg): δ 9.19 (s, 1H), 8.86 (s, 1H), 8.33 (d, 1H, 7= 5.3 Hz), 8.21 (dd, 1H, 7=2.0 and 8.8 Hz), 7.52 (d, 1H, 7 = 8.5 Hz), 7.45 (s, 1H), 7.18 (d, 1H, 7 15 =5.3 Hz), 6.81 (d, 1H, 7 = 8.5 Hz), 6.62 (d, 1H, 7 = 8.8 Hz), 4.95 (s, 1H),4.68($, 1H), 4.50 (s, 1H), 4.12 (s, 1H), 3.89 (d, 1H, 7 = 7.3 Hz), 3.79 (d, 1H, 7 = 7.3 Hz), 3.70 (d, 1H, 7 = 7.0 Hz), 3.49 (d, 1H, 7 = 9.9 Hz), 3.2 (d, 1H, 7 = 9.9 Hz), 3.04 (d, 1H, 7 = 9.6 Hz), 2.18 (s, 3H), 1.94-1.85 (m, 3H), 1.75 (d, 1H, 7 = 9.1 Hz); LCMS: purity: 99%; MS (m/e): 457 (MH*); 20 4-(6-(3-methylbutyl)aminopyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #217, 'H NMR (DMSO-d6): 6 9.12 (s, 1H), 8.79 (d, 1H, J = 2.3 Hz), 8.29 (d, 1H, J = 4.7 Hz) 8.06 (dd, 1H, J = 2.3 and 8.8 Hz), 7.47 (d, 1H, J = 8.8 Hz), 7.43 (d, 1H, J = 2.3 Hz), 7.12 (d, 1H, J = 4.7 Hz), 7.06 (t, 1H, J = 5.3 Hz), 6.74 (d, 1H, J = 8.8 Hz), 25 6.53 (d, 1H, J =8.8 Hz), 3.87 (s, 1H), 3.21-3.12 (m, 2H), 2.72 (d, 1H, J = 9.3 Hz) 2.66 (d, 1H, J= 9.3 Hz), 2.26 (s, 3H), 2.18 (s, 3H), 1.73 (d, 1H, J =8.5 Hz), 1.69-1.63 (m, 2H), 1.46-1.39 (app qt, 2H, J = 7.3 Hz), 0.89 (d, 6H, 7= 6.7 Hz); LCMS: Purity: 99%; MS (m/e): 458 (MH’); 4-(6-(3,3-dimethylbutyl)aminopyridin-3-yl)-W-(3-methyl-4-((1S,4S)-5-methyl-2,5-

30 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #218,1H NMR (DMSO-de): 5 9.12 (s, 1H), 8.79 (d, 1H, J = 2.3 Hz),8.30 (d, 1H, 7 = 5.3 Hz), 8.06 (dd, 1H, J = 2.3 and 8.8 Hz), 7.48 (d, 1H, 7 = 8.5 Hz), 7.43 (d. 1H, 7=2.3 Hz), 7.13 (d, 1H, J= 5.3 Hz), 7.01 (t, 1H, J= 5.3 Hz), 6.74 (d, 1H, J = 8.5 Hz), 6.51 (d, 1H, 7=9.1 Hz), 3.88 (s, 1H), 3.16-3.12 (m, 2H), 2.73 (d, 1H, 7 = 9.3 Hz), 214 215 2.68 (d, 1H, J = 9.3 Hz), 2.27 (s, 3H), 2.18 (s, 3H), 1.77 (d, 1H, J= 9.3 Hz), 1.68 (d, 1H, J = 9.3 Hz), 1.49-1.43 (m, 2H), 0.92 (s, 9H); LCMS: Purity: 99%; MS (m/e): 472 (MH+); 4-(6-(2-methoxyethyi){methyl)aminopyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyi-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #219,1H NMR (DMSO-de): δ 9.16 (s, 1H), 8.86 (d, 1H, J= 2.3 Hz), 8.32 (d, 1H, 7 = 5.3 Hz), 8.20 (dd, 1H, J = 2.3 and 9.1 Hz), 7.49 (d, 1H, J = 8.5 Hz), 7.43 (d, 1H, J = 2.3 Hz), 7.18 (d, 1H, J =5.3 Hz), 6.77 (d, 1H, J = 9.1 Hz), 6.74 (d, 1H, J = 8.5 Hz), 3.88 (s, 1H), 3.75 (t, 2H, J = 5.8 Hz), 3.51 (t, 2H, J = 5.3 Hz), 3.23 (app s, 3H), 3.18-3.12(m, 2H), 3.08 (s, 3H), 2.73 (d, 1H,7 = 9.1 Hz), 2.66 (d, 1H,7 = 9.1 Hz), 2.26 (s, 3H), 2.18 (s, 3H), 1.77 (d, 1H, 7 = 9.4 Hz), 1.68 (d, 1H, J = 9.3 Hz). LCMS: Purity: 99%; MS (m/e): 460 (MH+); 4-(6-(2-methoxyethyl)(methyl)aminopyridin-3-yl)-A/-(3-methyi-4-((1S,4S)-5-oxa-2- azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #220,1H NMR (DMSO-ck): δ 9.19 (s, 1H), 8.87 (d, 1H, J= 2.3 Hz), 8.33 (d, 1H, 7 = 5.3 Hz), 8.20 (dd, 1H, 7=2.3 and 9.1 Hz), 7.53 (d, 1H, J = 9.1 Hz), 7.45 (d, 1H, 7 = 2.3 Hz), 6.81 (d, 1H, 7=9.1 Hz), 6.75 (d, 1H, 7 = 9.1 Hz), 4.50 (s, 1H), 4.12 (s, 1H), 3.89 (d, 1H, 7 = 7.3 Hz), 3.78-3.69 (m, 3H), 3.51 (t, 3H, J = 5.3 Hz), 3.23 (s, 3H), 3.08 (s, 3H), 3.03 (d, 1H, 7 = 9.6 Hz), 2.18 (s, 3H), 1.87 (d, 1H, 7 = 9.1 Hz), 1.75 (d, 1H, 7 = 9.1 Hz); LCMS: Purity: 99%; MS (m/e): 447 (MH+); 4-(6-(2-methoxyethyl)(methyi)aminopyridin-3-yl)-/\/-(3-methyl-4-(1,5,7-trimethyl-3l7-diazabicyclo[3.3.1]nonan-3-yl)phenyl)pyrimidin-2-amine, compound #221,1H NMR (DMSO-cfe): δ 9.23 (s, 1H), 8.87 (d, 1H, 7= 2.3 Hz), 8.34 (d, 1H, 7 = 5.3 Hz) 8.20 (dd, 1H, 7 = 2.3 and 9.1 Hz), 7.55 (d, 1H, 7 = 8.5 Hz), 7.48 (d, 1H, J = 2.3 Hz), 7.20 (d, 1H, 7 = 5.3 Hz), 6.86 (d, 1H, 7 = 8.8 Hz), 6.76 (d, 1H, 7 = 9.1 Hz), 3.76 (t, 2H, 7= 5.3 Hz), 3.51 (t, 2H, 7 = 5.3 Hz), 3.23 (s, 3H), 3.08 (s, 3H), 2.85 (d, 2H, 7= 10.8 Hz), 2.70 (d, 2H, 7= 10.8 Hz), 2.31 (s, 3H), 2.07 (s, 3H), 1.76 (d, 2H, 7= 11.4 Hz), 1.19-1.02 (m, 2H), 0.82 (s, 6H); LCMS: Purity: 99%; MS (m/e): 516 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-((1 $,4/?)-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #222,1H NMR (DMSO-d6): δ 9.17 (s, 1H), 8.91 (d, 1H, 7 = 2.3 Hz), 8.34 (d, 1H, 7 = 5.3 Hz), 8.25 (d, 1H, 7 = 2.3 and 8.8 Hz), 7.45 (d, 1H, 7 = 8.5 Hz), 7.41 (d, 1H, 7 = 2.0 Hz), 7.20 (d, 1H, 7 = 5.3 Hz), 6.95 (d, 1H, 7 = 8.8 Hz), 6.73 (d, 1H, 7 = 8.8 Hz), 3.81 (s, 1H), 3.69-3.67 (m, 215 216 4H), 3.57-3.55 (m, 4H), 2,75 (d, 1H, 7 = 8.5 Hz), 2.18 (s, 3H), 1.81-1.56 (m, 4H), 1.38-1.29 (m, 2H); LCMS: Purity: 99%; MS (m/e): 443 (MH+); 4-(2,2-dimethyi-3-oxo-3,4-dihydro-2B-pyrido[3,2-b][1,4]oxazin-7-yl)-/\/-(3-methyl-4- ((1S,4R)-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #223, LCMS: Purity: 99%; MS (m/e): 457 (MH+); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2B-pyrido[3,2-0][1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicycloi2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine and 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido(3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yl)phenyl)pyrimidin-2-amine (68:31), compound #224, Mixture: LCMS: Purity: 99% (68:31); MS (m/e): 521 (MH+); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2B-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methyisulfonyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine 1H NMR (DMSO-d6): δ 11.50 (s, 1H), 9.52 (s, 1H), 8.75 (d, 1H, J = 2.3 Hz), 8.49 (d, 1H, J = 5.3 Hz), 8.04 (d, 1H, J = 2.3 Hz), 7.62 (s, 1H), 7.55 (dd, 1H, J = 2.3 and 8.5 Hz), 7.39 (d, 1H, J = 5.3 Hz), 7.13 (d, 1H, 7 = 8.5 Hz), 4.10 (s, 1H), 3.26-3.25 (m, 1H), 3.12-3.05 (m, 2H), 2.91 (s, 3H), 2.62 (s, 1H), 2.27 (s, 3H), 2.20-2.17 (m, 1H), 1.70-1.60 (m, 3H), 1.45 (s, 6H); LCMS: Purity: 95%; MS (m/e): 535 (MH+); 4-(6-(morpho!in-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2- azabicyclo[2.2.1]heptan-5-yi)phenyl)pyrimidin-2-amine and 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yl)phenyi)pyrimidin-2-amine (85:15), compound #225, Mixture: LCMS: Purity: 97% (85:15); MS (m/e): 521 (MH+); 4-(2,2-dimethyl-3-oxo-3,4“dihydro-2B-pyrido[312-b][1,4]oxazin-7-yl)-/V-(4-(2-methylsulfonyl-2-azabicycio[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine, compound #226, 1H NMR (DMSO-d6): δ 11.51 (s, 1H), 9.61 (s, 1H), 8.74 (d, 1H, J = 1.8 Hz), 8.50 (d, 1H, J = 4.3 Hz), 8.03 (s,1 H), 7.70-7.69 (d, 2H, J = 8.8 Hz), 7.40 (d, 1H, J = 4.3 Hz), 7.20 (d, 1H, J = 8.5 Hz), 4.10 (s, 1H), 3.26-3.23 (m, 1H), 3.09-2.99 (m, 2H), 2.90 (s, 3H), 2.58 (s, 1H), 2.20-2.13 (m, 1H), 1.79-1.53 (m, 3H), 1.45 (s, 6H); LCMS: Purity: 96%; MS (m/e): 521 (MH"j; 4-(6-(morpholin-4-y0pyridin-3-yl)-/V-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)pyrimidin-2-amine, compound #227,1H NMR (DMSO-d6): δ 9.62 (s, 1H),8.90 (s, 1H),8.43 (d, 1H, 7 = 5.5 Hz), 8.32 (appd, 2H,7 = 9.1 Hz), 7.72-7.69 (m, 2H), 7.33 (d, 1H, J = 5.5 Hz), 7.20 (d, 1H, 7 = 8.8 Hz), 7.04 (d, 1H, 7 = 9.1 Hz), 4.11 (s, 1H), 3.71-3.69 (m, 4H), 3.62-3.60 (m, 4H), 3.25-3.22 (m, 1H), 3.10- 216 217 2.99 (m, 2H), 2.90 (S, 3H), 2.59 (s, 1H), 2.20-2.13 (m, 1H), 1.78-1.54 (m, 3H); LCMS: Purity: 96%; MS (m/e): 507 (MH+); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-/?][1,4]oxazin-7-yl)-N-(4-(2- methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yl)phenyl)pyrimidin-2-amine, compound #228, 1H NMR (DMSO-cfe): δ 11.51 (s, 1H), 9.64 (s, 1H), 8.74 (d, 1H, J = 1.8 Hz), 8.50 (d, 1H, 7= 5.3 Hz), 8.03 (d, 1H, J= 1.8 Hz), 7.72 (d, 2H, J = 8.8 Hz), 7.41 (d, 1H, J = 5.3 Hz), 7.17 (d, 2H, J = 8.8 Hz), 4.01 (s, 1H), 3.22-3.17 (m, 2H), 2.98-2.95 (d, 1H, J = 8.2 Hz), 2.91 (s, 3H), 2.67 (s, 1H), 1.92-1.86 (m, 2H), 1.60-1.50 (m, 2H), 1.45 (s, 6H); LCMS: Purity: 97%; MS (m/e): 521 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1]heptan-6-yi)phenyl)pyrimidin-2-amine, compound #229,1H NMR (DMSO-d6): δ 9.59 (s, 1H), 8.92 (s, 1H), 8.42 (d, 1H, 7= 5.0 Hz), 8.31 (d, 1H, J = 9.1 Hz), 7.73 (d, 2H, J = 8.5 Hz), 7.32 (d, 1H, J = 5.0 Hz), 7.16 (d, 2H, J = 8.5 Hz), 7.02 (d, 1H, J = 9.1 Hz), 4.01 (s, 1H), 3.70-3.68 (m, 4H), 3.61-3.59 (m, 4H), 3.23-3.16 (m, 2H), 2.98- 2.95 (d, 1H, 7 = 8.2 Hz), 2.91 (s, 3H), 2.67 (s, 1H), 1.92-1.89 (m, 2H), 1.60-1.47 (m, 2H); LCMS: Purity: 87%; MS (m/e): 507 (MH+); 4-(6-(thiamorpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #230, 1H NMR (DMSO-d6): δ 9.19 (s, 1H), 8.88 (s, 1H), 8.34 (d, 1H, J = 5.3 Hz), 8.22 (d, 1H, 7 = 8.8 Hz), 7.49 (d, 1H, 7 = 8.8 Hz), 7.44 (s, 1H), 7.20 (d, 1H, J = 5.3 Hz), 6.96 (d, 1H, 7=9.1 Hz), 6.74 (d, 1H, 7 = 9.1 Hz), 3.99 (s, 4H), 3.88 (s, 1H), 3.19 (d, 1H, 7=9.1 Hz), 3.15 (d, 1H, 7=9.1 Hz), 2.73 (d, 1H, 7=9.1 Hz), 2.67 (d, 1H, 7 = 9.1 Hz), 2.61 (s, 4H), 2.26 (s, 3H), 2.18 (s, 3H), 1.77 (d, 1H, 7 = 9.1 Hz), 1.68 (d, 1H, 7= 9.1 Hz); LCMS: Purity: 99%; MS (m/e): 474 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-((1Sl4S)-5-methyl-2,5- diazabicycio[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine as a hemi-succinate salt, compound #231; 4-(1 -(pyridin-4-yl)-1 H-indol-5-yl)-N-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #232,1H NMR (DMSO-d6) 300 MHz): δ 9.27 (s, 1H), 8.72 (m, 2H), 8.50 (s, 1H), 8.43 (d, 1H, 7 = 5.4 Hz), 8.09 (d, 1H. J = 8.7 Hz), 7.92 (m, 2H), 7.75 (dd, 2H, 7 = 1.5 &amp;amp; 4.3 Hz), 7.51 (m, 2H), 7.35 (d, 1H, J = 5.4 Hz), 6.92 (d, 1H, J = 3.3 Hz), 6.76(d, 1H, 7 = 8.4 Hz), 3.90 (s, 1H), 3.19 (m, 3H), 2.72 (q, 2H, 7= 8.4 Hz), 2.28 (s, 3H), 2.22 (s, 3H), 1.79 (d, 1H, 7 = 9.3 Hz),1.70 (d, 1H, 7 = 8.7 Hz); LCMS {m/z}: 488 (MH+); 217 218 4-(1 -(pyridin-4-yl)-1 /7-indol-5-yt)-N-(3-fluoro-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #233,1H NMR ((DMSO-de, 300 MHz): δ 9.48 (s, 1H), 8.71 (d, 1H, 7= 5.1 Hz), 8.49 (s, 1H), 8.46 (d, 1H, J= 5.4 Hz), 8.25 (s, 1H), 8.09 (d, 1H, J= 8.7 Hz), 7.92 (m, 2H), 7.74 (m, 2H), 7.39 (d, 2H, J = 4.8 Hz), 6.92 (d, 1H, J = 3.3 Hz), 6.71 (t, 1H, J = 9.9 Hz), 4.19 (s, 1H), 3.22 (m, 3H), 2.72 (q, 2H, 7 = 8.4 Hz), 2.29 (s, 3H), 1.84 (d, 1H, J = 9.6 Hz),1.74 (d, 1H, J = 9.3 Hz); LCMS (m/z): 492 (MH+); 4-(1-(pyridin-4-y!)-1H-indol-5-yl)-A/-(3-methyl-4-((1S,4S)-5-ethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine, compound #234,1H NMR ((DMSO-de, 300 MHz): δ 9.28 (s, 1H), 8.72 (d, 2H, J = 6.0 Hz), 8.50 (s, 1H), 8.42 (d, 1H, J = 5.4 Hz), 8.09 (d, 1H, J = 9.0 Hz), 7.92 (m, 2H), 7.75 (d, 2H, J = 6.0 Hz), 7.50 (m, 2H), 7.35 (d, 1H, J = 5.4 Hz), 6.92 (d, 1H, J = 3.6 Hz), 6.76(d, 1H, 7= 8.7 Hz), 3.93 (s, 1H), 3.49 (s, 1H), 3.19 (s, 3H), 2.80 (m, 2H), 2.22 (s, 3H), 1.74 (m, 3H), 0.98 (t, 3H, J = 7.2 Hz); LCMS (m/z): 502 (MH+); 4-(1 -(pyridin-4-yl)-1 W-indol-5-yl)-/V-(3-methyl-4-((1 S,4$)-5-isobutyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #235,1H NMR ((DMSO-dg, 300 MHz): δ 9.27 (s, 1H), 8.72 (m, 2H), 8.50 (s, 1H), 8.42 (d, 1H, J = 5.4 Hz), 8.09 (d, 1H, J = 8.7 Hz), 7.92 (m, 2H), 7.75 (dd, 2H, J = 1.5 &amp;amp; 4.3 Hz), 7.51 (m, 2H), 7.35 (d, 1H, 7=5.4 Hz), 6.92 (d, 1H, J = 3.6 Hz), 6.74 (d, 1H, J = 8.7 Hz), 3.91 (s, 1H), 3.39 (m, 1H), 3.20 (s, 2H), 2.81 (s, 1H)), 2.69 (s, 1H), 2.25 (s, 2H), 2.20 (s, 3H), 1.73 (m, 2H),1.56 (s, 1H), 0.85 (d, 6H, 7 = 6.3 Hz); LCMS (m/z): 530 (MH+); 4-(7-oxo-5,6,7,8-tetahydro-1,8-naphthyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5- methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #237, 1H NMR (DMSO-76): δ 10.75 (1H, s), 9.38 (1H, s), 8.89 (1H, d, 7 = 8.5 Hz), 8.45 (1H, d, 7 = 5.2 Hz), 8.34-8.32 (m, 1H), 7.56 (1H, s), 7.48 (1H, d, 7 = 8.5 Hz), 7.32 (1H, d, 7 = 5.2 Hz), 6.89 (1H, d, 7 = 8.8 Hz), 4.35 (1H, s), 4.17 (1H, s), 3.07-2.97 (7H, m), 2.58-2.57 (4H, m), 2.23 (3H, s), 1.88 (2H, dd, J = 25.2, 9.2 Hz); MS; 506 (M+H); 4-(6-(propylamino)pyridin-3-yl)-N-(3-methyl-4-((1Sl4S)-5-methylsulfonyl-2l5- diazabicyclo(2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine&gt; compound #238,1H NMR (DMSO-de): δ 9.23 (s, 1H), 8.77 (s, 1H), 8.33 (d, 1H, 7 = 5.3 Hz), 8.11 (d, 1H, J = 9.1 Hz), 7.53 (d, 1H, 7 = 8.5 Hz), 7.48 (s, 1H), 7.31 (brs, 1H), 7.16 (d, 1H, 7=5.3 Hz), 6.88 (d, 1H, 7 = 8.5 Hz), 6.60 (d, 1H, 7= 9.1 Hz), 4.33 (s, 1H),4.14 218 219 (s, 1 Η), 3.41-3.22 (m, 6H), 2.95 (s, 3H), 2.19 (s, 3H), 1.90 (d, 1H, J= 9.1 Hz), 1.88 (d, 1H, J = 9.1 HZ), 1.55 (m, 2H), 0.90 (t, 3H, J = 7.4 Hz); LCMS: Purity: 99%; MS (m/e): 494 (MH+); 4-(3-oxo-3,4-dihydro-2H-benzo[t»][1,4]thiazin-7-yl)-A/-(4-((1S,4S)-5-methy 1-2,5-

5 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #239,1H NMR (CD3OD, 300 MHz): δ 8.33 (m, 2H), 8.12 (s, 1H), 7.91 (m, 1H), 7.56 (m, 3H), 7.08 (m, 2H), 6.69 (m, 1H), 4.62 (s, 1H), 4.33 (s, 1H), 3.81 (m, 1H), 3.70 (m, 3H), 2.93 (s, 3H), 2.34 (m, 2H), 2.31 (m, 2H); MS (ES) 445.03 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1Sl4$)- 10 5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #240, 1H NMR (CD3OD, 300 MHz): δ 8.35 (m, 1H), 7.75 (m, 2H), 7.52 (m, 2H), 7.20 (m, 1H), 6.96 (m, 2H), 4.25 (m, 2H), 3.95 (m, 1H), 3.48 (m, 2H), 3.16 (m, 1H), 2.97 (s, 3H), 2.32 (m, 5H), 1.50 (s, 6H); MS (ES) 471.06 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-benzo[d][1,4]oxazin-7-yl)-N-(3-methy 1-4-(( 1S, 4$)- 15 5-methy!sulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #241, 1H NMR (CD3OD, 300 MHz): δ 8.31 (m, 1H), 7.71 (m, 2H), 7.46 (m, 2H), 7.10 (m, 2H), 6.95 (m, 2H), 4.44 (s, 1H), 4.19 (s, 1H), 3.63-3.37 (m, 4H), 2.94 (s, 3H), 2.31 (s, 3H), 2.03 (m, 2H), 1.51 (s, 6H); MS (ES) 535.12 (M+H); 4-(2-oxo-2,3,4,5-tetrahydro-1W-benzo[b]azepin~7-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-

20 2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #242,1H NMR (CD3OD, 300 MHz): δ 8.38 (m, 1H), 8.04 (m, 2H), 7.52 (m, 2H), 7.20 (m, 2H), 7.25 (m, 1H), 7.10 (m, 1H), 6.96 (m, 1H), 4.30 (s, 1H), 4.24 (s, 1H), 3.79 (m, 1H), 3.48 (m, 2H), 3.24 (m, 1H), 2.97 (s, 3H), 2.88 (m, 2H), 2.33 (m, 9H); MS (ES) 455.14 (M+H); 25 4-(2-oxo-2,3,4,5-tetrahydro-1 /-/-benzo[b]azepin-7-yl)-N-(3-methyl-4-((1 $,4$)-5- methylsulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #243,1H NMR (CD3OD, 300 MHz): δ 8.23 (m, 1H), 8.16 (m, 2H), 7.52 (m, 3H), 7.15 (m, 2H), 4.50 (s, 1H), 4.42 (s, 1H), 3.65 (m, 4H), 2.97 (s, 3H), 2.88 (m, 2H), 2.36-2.11 (m, 9H); MS (ES) 519.13 (M+H); 30 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-benzo[d][1,4]oxazin-7-yl)-A/-(3-methyl-4-((6R, 9S)- 6,9-methanooctahydro-1W-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrimidin-2-amine, compound #244,1H NMR (CD3OD, 300 MHz): δ 8.42 (s, 1H), 8.36 (m, 1H), 7.76 (m, 2H), 7.55 (m, 2H), 7.21-7.10 (m, 2H), 6.97 (m, 1H), 3.95 (m, 2H), 3.70-3.48(m, 3H), 2.58 (m, 1H), 2.41 (m, 1H), 1.34 (s, 3H), 1.97-1.66 (m, 6H), 1.51 (s, 219 220 6H); MS (ES) 511.13 (M+H); 4-(6-(morpholin-4-yl)pyndin-3-yi)-A/-(3-methyl-4-((6R,9S)-6,9-methanooctahydro-1H-pyrido[1,2-a)pyrazin-2-yl)phenyl)pyrimidin-2-amine, compound #245,1H NMR (CD3OD, 300 MHz): δ 8.90 (m, 1H), 8.40 (s, 1H), 8.32-8.21 (m, 2H), 7.49 (m, 2H), 7.13 (m, 2H), 6.87 (m, 1H), 4.01-3.91 (m, 2H), 3.81-3.48(m, 11H), 3.13 (m, 2H), 2.56 (m, 1H), 2.39 (m, 1H), 2.39 (m, 1H), 2.33 (s, 3H), 1.91-1.66 (m, 6H), 1.51 (s, 6H); MS (ES) 498.13 (M+H); 4-(6-(dimethylamino)pyridin-3-yl)-A/-(6-((1S,4S)-5-rTiethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #54, LCMS: purity: 99%; MS (m/e): 403 (MH+); 4-(6-(methylcarbonylamino)pyridin-3-yl)-/V-(6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #55, LCMS: purity: 99%; MS (m/e): 417 (MH+); 4-(4-(dimethylamino)phenyl)-/V-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyndin-3-yl)pyrimidin-2-amine, compound #56,1H NMR (DMSO-d6): δ 9.15 (s, 1H), 8.44 (s, 1H), 8.28 (d, 1H, J = 6Hz), 7.91 (m, 3H), 7.15 (d, 1H, J=5.6Hz), 6.78 (d, 2H, J= 10 Hz), 6.57 (d, 1H, J = 11.5 Hz), 4.65 (s, 1H), 3.51 (m, 2H), 2.98 (s, 6H), 2.69 (m, 2H), 2.57 (s, 3H), 2.08 (m, 1H), 1.93 (m, 1Hz); LCMS: purity: 99%; MS (m/e): 402 (MH+); 4-(6-(4-acetylpiperazin-1-yl)pyridtn-3-yl)-N-(6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #57,1H NMR (DMSO-c/6): δ 9.21 (s, 1H), 8.88 (s, 1H), 8.41 (s, 1H), 8.34 (d, 1H, J = 6 Hz), 8.20 (m, 1H), 7.83 (m, 1H), 7.22 (d, 1H, J= 5.1 Hz), 6.95 (d, 1H, J = 9.3 Hz), 6.53 (d, 1H, J = 9.3 Hz), 4.60 (s, 1H), 3.59 (m, 12 H), 2.92 (m, 1H), 2.44 (s, 3H), 2.01 (m, 4H), 1.79 (m, 1H); LCMS: purity: 99%; MS (m/e): 486 (MH+); 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-/V-(6-((1S14S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #58, LCMS: purity: 99%; MS (m/e): 459 (MH+); 4-(6-(dimethylamino)pyridin-3-yl)-A/-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #61, LCMS: purity: 99%; MS (m/e): 417 (MH+); 4-(4-(dimethylamino)phenyl)-/V-(5-methyl-6-((1S,4S)-(5-methyl-2,5- diazabicycio[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #62, LCMS: purity: 99%; MS (m/e): 416 (MH+); 4-(6-(4-acetylpiperazin-1-yl)pyridin-3-yl)-/V-(5-methyl-6-((1S,4$)-5-methyl-2,5- 220 221 diazabicyclo[2.2.1 ]heptan-2-yi)pyridin-3-yl)pyrimidin-2-amine, compound #63, LCMS: purity: 99%; MS (m/e): 500 (MH+); 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-A/-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #64, 5 LCMS: purity: 99%; MS (m/e): 473 (MH+); 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yi)-N-(5-methyl-6-((1 S,4$)-5- methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-y!)pyrimidin-2-amine, compound #65, LCMS: purity: 99%; MS (m/e): 445 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(5-methyl-6-((1$,4S)-5-methyi-2,5- 10 diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #66, LCMS: purity: 99%; MS (m/e): 459 (MH+); 4-(4-(i-butylcarbonylamino)phenyl)-N-(5-methyl-6-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #131,1H NMR (CD3OD, 300 MHz): δ 9.26 (m, 1H), 8.64 (m, 1H), 8.41 (m, 1H), 8.11 (m, 15 2H), 7.90 (m, 1H), 7.74 (m, 2H), 7.37 (m, 1H), 4.29 (s, 1H), 4.40 (m, 2H), 3.99 (m, 2H), 3.36 (m, 1H), 3.24 (m, 1H), 3.01 (s, 3H), 2.40 (m, 5H), 1.33 (s, 9H); MS (ES) 472.12 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-(5-methyl-6- ((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2- 20 amine, compound #138, Ή NMR (CD3OD, 300 MHz): δ 8.69 (m, 1H), 8.56 (m, 1H), 8.45 (m, 1H), 8.00 (m, 2H), 7.90 (m, 1H), 7.31 (m, 1H), 4.78 (m, 1H), 4.38 (s, 1H), (m, 1H), 4.08 (m, 1H), 3.96 (m, 1H), 3.63 (m, 1H), 3.23 (m, 1H), 3.00 (s, 3H), 2.38 (m, 5H), 1.54 (s, 6H); MS (ES) 473.10 (M+H); 4-(4-(3-cyciopropylureido)phenyi)-N-(5-methyl-6-((1S,4S)-5-methyl-2,5-

25 diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #140,1H NMR (CD3OD, 300 MHz): δ 8.46 (m, 1H), 8.33 (m, 1H), 8.15 (m, 1H), 8.03 (m, 2H), 7.85 (m, 1H), 7.53 (m, 2H), 7.20 (m, 1H), 4.65 (s, 1H), 4.31 (s, 1H), 3.92 (m, 2H), 3.58 (m, 1H), 2.96 (s, 3H), 2.61 (m, 1H), 2.30 (m, 5H), 0.76 (m, 2H), 0.53 (m, 3H); MS (ES) 471.57 (M+H); 30 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-/V-(5-methyl-6-((1S,4$)-5-methyJ-2,5- diazabicycio[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #144, 1H NMR (CD3OD, 300 MHz): δ 9.10 (m, 1H), 8.53 (m, 3H), 8.25 (m, 1H), 7.87 (m, 1H), 7.33 (m, 1H), 4.23 (m, 4H), 3.98 (m, 4H), 3.46 (m, 4H), 3.34 (m, 1H), 3.23 (m, 1H), 2.99 (s, 3H), 2.35 (m, 6H); MS (ES) 516.07 (M+H); 221 222 4-(6-aminopyridin-3-yl)-W-(5-methyl-6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2- yi)pyridin-3-yl)pyrimidin-2-amine, compound #145,1H NMR (CD3OD, 300 MHz): δ 8.70 (m, 1H), 8.39 (m, 1H), 8.33 (m, 1H), 8.20 (m, 3H), 7.84 (m, 1H), 7.14 (m, 1H), 6.66 (m, 1H), 4.64 (s, 1H), 4.30 (s, 1H), 3.99 (m, 1H), 3.86 (m, 1H), 3.58 (m, 5 1H), 2.96 (s, 3H), 2.65 (m, 1H), 2.30 (m, 5H); MS (ES) 389.01 (M+H); 4-(6-(acetamido)pyridin-3-yi)-/\/-(5-methyl-6-((1S,4S)-5-rnethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #146,1H NMR (CD3OD, 300 MHz): δ 9.02 (m, 1H), 8.44 (m, 2H), 8.23 (m, 2H), 7.83 (m, 1H), 7.25 (m, 1H), 4.65 (s, 1H), 4.30 (s, 1H), 4.00 (m, 1H), 3.85 (m, 1H), 3.59 (m, 10 2H), 2.96 (s, 3H), 2.65 (m, 1H), 2.30 (s, 3H), 2.21 (m, 2H); MS (ES) 431.05 (M+H); 4-(6-(™β^ΐ8υΙίοηνΐ8™ίηο)ργπύίη-3ψ)-Ν-(5-™β^Ι-6-((15,45)-5-ωβ1ΐΊνΙ-2Ι5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #154,1H NMR (CD3OD, 300 MHz); δ 8.96 (m, 1H), 8.41 (m, 2H), 8.20 (m, 2H), 7.83 (m, 15 1H), 7.20 (m, 2H), 4.65 (s, 1H), 4.30 (s, 1H), 4.02-3.57 (m, 3H), 2.97 (s, 3H), 2.30 (m, 6H); MS (ES) 467.02 (M+H); 4-(2-(dimethylamino)thiazol-4-yl)-A/-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #177,1H NMR (DMSO-d6): δ 9.20 (s, 1H), 8.41 (d, 1H, J = 4.7 Hz), 8.33 (s, 1H), 7.86 (d, 1H, J = 8.5 Hz), 7.47 (s, 20 1H), 7.18 (d, 1H, 7 = 4.7 Hz), 6.47 (d, 1H, 7 = 9.1 Hz), 4.48 (s, 1H), 3.40-3.37 (m, 2H), 3.23 (d, 1H, 7 = 9.7 Hz), 3.07 (s, 6H), 2.77 (d, 1H, 7= 9.1 Hz), 2.42 (d, 1H, 7 = 9.7 Hz), 2.24 (s, 3H), 1.83 (d, 1H, 7=9.1 Hz), 1.70 (d, 1H, 7=9.1 Hz); LCMS: purity: 99%; MS (m/e): 409 (MH+); 4-(5-(morpholin-4-yl)pyrazin-2-yl)-A/-(6-((1$,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan- 25 2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #180,1H NMR (DMSO-d6): δ 9.25 (s, 1H), 8.94 (s, 1H), 8.42-8.36 (m, 3H), 7.83 (dd, 1H, 7 = 2.0 and 9.1 Hz), 7.35 (d, 1H, 7 = 4.9 Hz), 6.51 (d, 1H, 7=9.1 Hz), 4.50 (s, 1H), 3.69-3.67 (m, 8H), 3.41-3.38 (m, 2H), 3.23 (d, 1H, 7 = 9.4 Hz), 2.77 (d, 1H, 7 = 9.4 Hz), 2.43 (d, 1H, 7 = 9.4 Hz), 2.23 (s, 3H), 1,83 (d, 1H, 7 = 9.7 Hz), 1.71 (d, 1H, 7=9.7 Hz); LCMS: 30 purity: 90%; MS (m/e): 446 (MH+); 4-(1 -(pyridin-4-yl)-1 H-indol-5-yl)-A/-(5-methyi-6-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yi)pyrimidin-2-amine, compound #236,1H NMR ((DMSO-d6, 300 MHz): δ 9.33 (s, 1H), 8.72 (d, 2H, 7 = 6.3 Hz), 8.50 (s, 1H), 8.48 (s, 1H), 8.43 (d, 1H, 7 = 5.1 Hz), 8.32 (s, 1H), 8.07 (d, 1H, J = 9.0 Hz), 7.92 222 223 (m, 2H), 779 (s, 1H), 775 (d, 2H, J = 6.3 Hz), 7.38 (d, 1H, 7= 5.4 Hz), 6.91 (d, 1H, 7 = 3.6 Hz), 4.36 (s, 1H), 3.38 (m, 2H), 279 (m, 2H), 2.27 (s, 3H), 2.23 (s, 3H), 1.77 (d, 1H, 7 = 87 Hz), 1.64 (d, 1H, 7= 9.0 Hz); LCMS (m/z): 489 (MH+); 4-(2,2-dimethyl-3-oxo-3)4-dihydro-2H~pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4- ((1S,4S)-5-(1-methylethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)pheny!)pyrimidin-2-amine, compound #246,1H NMR (DMSO-76, 300 MHz): δ 11.48 (b, 1H), 9.44 (d, 7 = 4.96 Hz, 1H), 8.73 (b, 1H), 8.46 (d, 7 = 4.95 Hz, 1H), 8.02 (b, 1H), 7.57 (tr, 7 = 19.53 Hz, 2H), 7.37(d, 7 = 4.40 Hz, 1H), 6.94 (m, 1H), 2.25-2.08 (m, 8H), 1.47 (s, 6H),1.36-1.23 (m, 9H); LCMS:purity; 95%; [M+H]+ = 500; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2W-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-cyclopropyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #247, 1H NMR (DMSO-d6, 300 MHz): δ 11.48 (b, 1H), 9.44 (d, 7 = 4.96 Hz, 1H), 873 (b, 1H), 8.46 (d, 7 = 4.95 Hz, 1H), 8.02 (b, 1H), 7.57(tr, 7 = 19.53 Hz, 2H), 7.37 (d, 7 = 4.40 Hz 1H), 6.94 (m, 1H), 2.5 (b, 8H), 2.21 (b, 3H), 1.86 (b, 1H), 1.47 (s, 6H), 0.91-0.87 (b, 4H); LCMS: purity; 100%;[M+H] += 498; 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yi)-/\/-(3-chloro-4- ((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pheny1)pyrimidin-2-amine, compound #248,1H NMR ( CD3OD, 300MHz): δ 8.68 (s, 1H), 8.42 (m, 1H), 8.31 (s, 1H), 7.98 (m, 2H), 7.53 (m, 1H), 7.27 (m, 1H), 7.08 (m, 1H), 4.40 (m, 2H), 3.81 (m, 2H), 3.61 (m, 1H), 2.97 (s, 3H), 2.66 (m, 4H), 2.29 (m, 2H), 1.55 (s, 6H); LCMS (m/z): 492.09 (MH+); 4-{2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-chloro-4- ((1$,4S)-5-(methyisulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #249, LCMS (m/z): 556.00 (ELSD); 4-(2,2-dimethyl-3-oxo-3)4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yi)-A/-(3-methyl-4-((1S,4S)-5-cyciopentyl-2,5-diazabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #250,1H NMR (CD3OD, 300 MHz): δ 8.44 (m, 2H), 8.09 (m, 1H), 8.00 (m, 1H), 7.77 (m, 1H), 7.27 (m, 1H), 6.95 (m, 1H), 478 (m, 1H), 4.50 (m, 1H), 4.05 (m, 1H), 3.71 (m, 3H), 3.51 (m, 1H), 2.31 (s, 3H), 2.27 (m, 4H), 174 (m, 4H), 1.54 (s, 6H) ppm; MS (ES) 526.2 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/-/-pyrido[3,2-Z&gt;][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-acetyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyt)pyrimidfn-2-amine, compound #251,1H NMR (CD3OD, 300 MHz): δ 8.67 (m, 1H), 8.42 (m, 1H), 8.00 (m, 2H), 771 (m, 1H), 7.24 (m, 1H), 6.88 (m, 1H), 3.63 (m, 3H), 3.38 (m, 3H), 223 224 2.15 (s, 3H), 2.01 (m, 2H), 1.54 (s, 6H) ppm; MS (ES) 500.2 (M+H); 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.1]octan-4-yl)phenyl)pyrimidin-2-amine, compound #252,1H NMR (CD3OD, 300 MHz): δ 8.71 (m, 1H), 8.41 (m, 1H), 7.59 (m, 2H), 7.25 (m, 2H), 7.12 (m, 1H), 3.91 (m, 1H), 3.57 (m, 5H), 3.27 (m, 2H), 3.07 (m, 1H), 2.36 (s, 3H), 2.13 (m, 2H), 1.54 (s, 6H) ppm; MS (ES) 472.1 (M+H); 4-(5-(1-methylethoxy)carbonylpropyl-6-aminopyridin-3-yl)-A/-(3-methyl-4-((1 $,48)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #253, 1H NMR (DMSO-d6, 300 MHz): δ 9.16 (s, 1H), 8.62 (b, 1H), 8.30 (d, J = 5.23Hz, 1H), 7.94 (b, 1H), 7.53 (b, 1H), 7.43 (d, J=8.53Hz, 1H), 7.16 (d, J = 5.22 Hz, 1H), 6.78(d, J = 8.52 Hz, 1H), 6.37 (b, 2H), 4.88-4.84 (m, 1H), 2.82 (b, 1H), 2.49-2.48 (m, 5H), 2.39-2.30 (m, 3H), 2.20 (s, 3H), 1.85-1.76 (m, 5H), 1.16 (d, J = 6.5Hz, 9H); LCMS:purity; 96.5%; [M+H]+ =516; 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1$,4S)-5-cyclopropyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amin,; compound #254,1H NMR (DMSO-d6, 300 MHz): δ 9.18 (s, 1H), 8.90 (b, 1H), 8.35 (d, J = 5.22 Hz, 1H), 8.26 (d, J = 9.08Hz, 1H), 7.48 (b, 2H), 7.21 (d, J = 5.23Hz, 1H), 6.96 (d, J = 9.36Hz, 1H), 6.76 (d, J = 8.80 Hz, 1H), 3.93 (b, 1H), 3.70 (d, J = 4.4Hz, 4H), 3.59 (d, J = 4.67 Hz, 4H) 2.87 (b, 2H), 2.49 (b,3H), 2.20 (s, 3H), 1.95 (b, 1H), 1.74 (d, J = 4.68 Hz, 2H), 0.37 (d, J = 23.39 Hz, 4H); LCMS: purity; 97%;[M+H]+ =484; 4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-chloro-4-((1Sl4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #255,1H NMR (CD3OD, 300MHz): δ 8.94 (s, 1H), 8.34 (m, 1H), 8.32 (s, 1H), 8.22 (m, 1H), 7.82 (m, 1H), 7.53 (Μ, 1H), 7.19 (m, 1H), 7.08 (m, 1H), 6.82 (m, 1H), 4.36 (m, 2H), 3.79 (m, 6H), 3.61 (m, 6H), 2.97 (s, 3H), 2.29 (m, 2H); LCMS (m/z): 478.05 (MH+); 4-(2-(trifluoromethyl)pyridin-4-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #256, LCMS (m/z): 441.05 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-chloro-4-((1S,4S)-5-(methylsulfonyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #257, LCMS (m/z): 541.00 (ELSD);

4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-chloro-4-((1$,4$)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #258, LCMS 224 225 (m/z): 557.02 (MH+); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-chloro-4-((1S,4S)-5-acetyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #259, LCMS (m/z): 506.01 (MH+); 5 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yi)-A/-(3-chloro-4-((1$,4S)-5-acetyl-2,5- diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine, compound #260, LCMS (m/z): 521.08 (MH+); 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-methyl-4-((1S,4$)-5-methyl-2,5-

diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #261,1H 10 NMR (CD3OD, 300 MHz): δ 8.89 (m, 1H), 8.36 (m, 2H), 7.55 (m, 1H), 7.45 (m, 1H), 7.18 (m, 1H), 6.99 (m, 1H), 6.88 (m, 1H), 5.28 (m, 1H), 4.25 (m, 2H), 3.94 (m, 2H), 3.76 (m, 1H), 3.55 (m, 5H), 2.97 (s, 3H), 2.30 (s, 3H), 2.06 (m, 3H), 1.76 (m, 3H) ppm; MS (ES) 473.2 (M+H); 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yi)-A/-(3-methyl-4-((1S,4S)-5-cyclopentyl-2,5-

15 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #262,1H NMR (CD3OD, 300 MHz): δ 8.88 (m, 1H), 8.42 (m, 1H), 8.34 (m, 1H), 8.05 (m, 1H), 7.79 (m, 1H), 7.23 (m, 1H), 6.94 (m, 1H), 6.86 (m, 1H), 5.29 (m, 1H), 4.00 (m, 4H), 3.62 (m, 7H), 2.32 (m, 7H), 1.75 (m, 10H) ppm; MS (ES) 527.2 (M+H); 4-(6-(morphoiin-4-yl)pyridin-3-yl)-/V-(3-chloro-4-((1S,4S)-5-(1-methylethyl)-2,5-

20 diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #263,1H NMR (DMSO-d6, 300 MHz): δ 9.18 (s, 1H), 8.90 (b, 1H), 8.35 (d, J= 5.22 Hz, 1H), 8.26 (d, J = 9.08 Hz, 1H), 7.48 (b, 2H), 7.21 (d, J = 5.23 Hz, 1H), 6.96 (d, J = 9.36 Hz, 1H), 6.76 (d, J = 8.80 Hz, 1H), 3.93 (b, 1H), 3.70 (d, J = 4.4 Hz, 4H), 3.59 (d, J = 4.67 Hz, 4H), 3.23-2.96 (m, 3H), 2.49 (b, 3H), 2.20 (s, 3H), 1.72 (b, 25 2H), 0.97 (d, J = 4.13 Hz, 6H); LCMS:purity; 99.7%; [M+H]+ =486; 4-(6-((1 $,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyridin-3-yl)-N-(3-methyl-4-((1$,4S)- 5-(methylsulfonyi)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #264, Ή NMR (DMSO-d6): δ 9.30 (s, 1H), 8.84 (s, IH), 8.35 (d, 1H, J = 5.0 Hz), 8.25 (d, 1H, J = 7.3 Hz), 7.53 (d, 1H, J= 8.8 Hz), 7.47 (s, 1H), 7.22 (d, 30 1H, J= 5.0 Hz), 6.88 (d, 1H, J = 8.5 Hz), 6.72 (d, 1H, J- 7.3 Hz), 4.98 (s, 1H), 4.69 (s, 1H), 4.33 (s, 1H), 4.15 (s, 1H), 3.79 (d, 1H, J = 6.7 Hz), 3.66 &lt;d, 1H, J = 6.7 hz), 3.53-3.39 (m, 6H), 2.95 (s, 3H), 2.20 (s, 3H), 1.95-1.80 (m, 4H). LCMS: Purity: 99%; MS (m/e): 534 (MH+); 4-(6-((1 R, 4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyridin-3-yl)-W-(3-methyl-4-((1S,4S)- 225 226 5-methyl-2,5-diazabicyclo[2.2J]heptan-2-yl)pheny0pyrimidin-2-amine, compound #265, 1H NMR (DMSO-76): δ 9.27 (s, 1H), 8.87 (d, 1H, J= 2.3 Hz), 8.33 (d, 1H, J = 5.3 Hz), 8.21 (dd, 1H, J = 2.0 and 8.8 Hz), 7.56 (d, 1H, 9.1 Hz), 7.48 (d, 1H, J = 5.3 Hz), 7.20 (d, 1H, J = 5.3 Hz), 6.86 (d, 1H, J = 8.8 Hz), 6.64 (d, 1H, J = 8.8 Hz), 4.96 (s, 1H), 4.68 (s, 1H), 3.79 (d, 1H, J = 6.7 Hz), 3.65 (d, 1H, J = 7.6 Hz), 3.5 (d, 1H, J= 10.2 Hz), 3.16 (m, 2H), 2.75 (d, 1H, J = 9,3Hz), 2.67 (d, 1H, J = 9.3 Hz), 2.29 (s, 3H), 2.20 (s, 3H), 1.90 (m, 4H); LCMS: purity: 99%; MS (m/e): 470 (MH*); 4-(6-((1 S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyridin-3-yl)-A/-(5-methyl-6-(( 1 S,4S)- 5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine, compound #266, 1H NMR (DMSO-d6): δ 9.22 (s, 1H), 8.85 (s, 1H), 8.34-8.33 (m, 2H), 8.18 (d, 1H, J = 6.7 Hz), 7.70 (s, 1H), 7.20 (d, 1H, J = 5.3 Hz), 6.65 (d, 1H, J = 8.8 Hz), 4.96 (s, 1H), 4.67 (s, 1H), 4.34 (s, 1H), 3.78 (d, 1H, J = 7.0 Hz), 3.64 (d, 1H, J = 7.0 Hz), 3.49 (d, 1H, J = 9.5 Hz), 3.42-3.36 (m, 4H), 2.74 (s, 2H), 2.24 (s, 3H), 2.19 (s, 3H), 1.92 (d, 1H, J = 9.1 Hz), 1.85 (d, 1H, J = 9.1 Hz), 1.74 (d, 1H, 7 = 9.1 Hz), 1.62 (d, 1H, 7 = 9.1 Hz). LCMS: Purity: 99%; MS (m/e): 471 (MH+); 4-(6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indo!-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #267,1H NMR (DMSO-d6l 300 MHz): δ 9.24 (b, 1H), 8.47 (d, 7 = 5.50 Hz, 1H), 8.20 (b, 1H), 7.88 (d, 7 = 7.1 6Hz, 1H), 7.55 (d, 7 = 5.50 Hz, 1H), 7.38 (b, 1H), 7.24-7.17 (m, 2H), 6.74 (d, 7 = 8.52 Hz, 1H), 3.91 (b, 1H), 3.20 (b, 4H), 3.05 (b, 3H), 8.30 (m, 3H), 2.32 (s, 3H), 2.18 (s, 3H), 1.81-1.71 (m, 5H); LCMS:purity; 98.1 %;[M+H] * =466; 4-(6,7,8,9-tetrahydro-5W-pyrido[2,3-b]indo!-3-yi)-A/-(3-methyl-4-((1 S,4S)-5- (methylsuJfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yf)phenyl)pyrimidin-2-amine, compound #268,1H NMR (DMSO-d6l 300 MHz): δ 9.24 (b, 1H), 8.47 (d, 7= 5.50 Hz, 1H), 8.20 (b, 1H), 7.88 (d, 7 = 7.16 Hz, 1H), 7.55 (d, 7= 5.50 Hz, 1H), 7.38 (b, 1H), 7.29-7.17 (m, 2H), 6.86 (b, 1H), 4.34 (b, 1H), 4:17 (b, 2H), 3.37-3.25 (m, 5H), 3.04 (b, 1H), 2.96 (s, 3H), 2.67 (b, 2H), 2.20 (b, 3H), 1.89-1.81 (m, 5H); LCMS:purity; 98.7%; [M+H] * = 530; 4-(4-(trifluoromethyl)phenyl)-/V-(3-methyl-4-((1S,4$)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #269, LCMS (m/z): 440.09 (MH+); 226 227 4-(7,8,9,9a-tetrahydro-5H-pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(11 H)-on-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #270,1H NMR (CD3OD, 300 MHz); δ 9.28 (m, 1H), 8.63 (m, 1H), 8.43 (m, 1H), 7.42 (m, 3H), 7.01 (m, 1H), 4.78 (m, 2H), 4.55 (m, 1H), 4.41 (m, 2H), 4.30 (s, 1H), 3.99 (m, 3H), 3.50-3.36 (m, 3H), 3.16 (m, 1H), 2.99 (s, 3H), 2.82 (m, 1H), 2.32 (m, 5H), 2.10 (m, 3H); MS (ES) 497.10 (M+H); 4-(2t2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[£&gt;][1,4]oxazin-7-yl)-A/-(3-cyano-4-((1S,4S)-5~ methyl-2,5-diazabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #271, 1H NMR (CD3OD, 300 MHz): δ 8.39 (m, 2H), 8.16 (m, 1H), 7.72 (m, 3H), 7.20 (m, 1H), 6.94 (m, 2H), 4.76 (s, 1H), 4.32 (s, 1H), 4.04 (m, 1H), 3.69 (m, 2H), 3.31 (m, 2H), 2.93 (s, 3H), 2.35 (m, 2H), 1.51 (s, 6H); MS (ES) 482.08 (M+H); 4-(2-oxo-2,3,4,5-tetrahydro-1/7-benzo[b]azepin-7-yl)-/V-(3-cyano-4-((1S,4S)-5-methyl-2l5-diazabicyclo[2,2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #272, 1H NMR (CD3OD, 300 MHz); δ 8.41 (m, 3H), 8.08 (s, 1H), 7.99 (m, 1H), 7.66 (m, 1H), 7.28 (m, 1H), 7.11 (m, 1H), 6.93 (m, 1H), 4.77 (s, 1H), 4.34 (s, 1H), 4.07 (m, 1H), 3.69 (m, 2H), 3.35 (m, 2H), 2.95 (s, 3H), 2.89 (m, 2H), 2.32 (m, 6H); MS (ES) 466.08 (M+H); 4-(3-oxo-3,4-dihydro-2H-benzo[£&gt;][1,4]thiazin-7-yl)-N-(3-cyano-4-((1$,4S)-5-rnethyl-2,5-diazabicyc!o[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #273,1H NMR (CD3OD, 300 MHz); δ 8.39 (m, 2H), 8.12 (s, 1H), 7.93 (m, 1H), 7.71 (m, 1H), 7.23 (m, 1H), 7.05 (m, 1H), 6.92 (m, 1H), 4.77 (s, 1H), 4.30 (s, 1H), 4.07 (m, 1H), 3.69 (m, 2H), 3.48 (s, 2H), 3.30 (m, 3H), 2.93 (s, 3H), 2.33 (m, 2H); MS (ES) 470.06 (M+H); 4-(3-oxo-3,4-dihydro-2/-/-benzo[d][1t4]thiazin-7-yl)-W-(3-methyi-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine, compound #274,1H NMR (CD3OD, 300 MHz): δ 8.36 (m, 2H), 8.17 (s, 1H), 7.91 (m, 1H), 7.48 (m, 2H), 7.19 (m, 1H), 7.04 (m, 1H), 6.96 (m, 1H), 4.29 (s, 1H), 4.24 (s, 1H), 3.81 (m, 1H), 3.52 (m, 4H), 2.97 (s, 3H), 2.33(s, 3H), 2.31 (s, 2H); MS (ES) 459.07 (M+H); 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-N-(3-methyl-4-(1l4-diazabicyclo[3.2.1]octan-4-yl)phenyl)pyrimidin-2-amine, compound #275,1H NMR (CD3OD, 300 MHz); δ 8.92 (m, 1H), 8.38 (m, 2H), 7.62 (m, 1H), 7.53 (m, 1H), 7.21 (m, 1H), 7.11 (m, 1H), 6.88 (m, 1H), 5.30 (m, 1H), 3.95 (m, 4H), 3.58 (m, 8H), 3.11 (m, 1H), 2.35 (s, 3H), 2.12 (m, 4H), 1.78 (m, 3H) ppm; MS (ES) 473.2 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/~(3-methyl-4-((R)-1,4-diazabicyclo[3.2.1joctan-4- 227 228 yl)phenyl)pynmidin-2-amine, compound #276, 1H NMR (CD3OD, 300 MHz): δ 8.92 (m, 1H), 8.32 (m, 1H), 8.24 (m, 1H), 7.59 (m, 1H), 7.55 (m, 1H), 7.13 (m, 2H), 6.86 (m, 1H), 3.92 (m, 1H), 3.79 (m, 4H), 3.61 (m, 9H), 3.31 (m, 1H), 3.10 (m, 2H), 2.35 (s, 3H), 2.13 (m, 2H) ppm; MS (ES) 458.1 (M+H); 4-(6-(morpholin-4-yl)pyndin-3-yl)-A/-(3-methyl-4-(($)-1,4-diazabicycloi3.2.1 ]octan-4-yl)phenyi)pyrimidin-2-amine, compound #277, 1H NMR (CD3OD, 300 MHz): δ 8.92 (m, 1H), 8.31 (m, 1H), 8.25 (m, 1H), 7.58 (m, 2H), 7.14 (m, 2H), 6.88 (m, 1H), 3.93 (m, 1H), 3.77 (m, 4H), 3.59 (m, 9H), 3.32 (m, 1H), 3.11 (m, 2H), 2.36 (s, 3H), 2.14 (m, 2H) ppm; MS (ES) 458.1 (M+H); 4-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-yl)-A/-(3-methyl-4-((6R,9S)-6,9-methanooctahydro-1H-pyrido[1,2-a]pyrazin-2-yl)phenyl)pynmidin-2-amine, compound #278, 1H NMR (CD3OD, 300 MHz): δ 8.37 (m, 2H), 8.05 (m, 2H), 7.58 (m, 1H), 7.25 (m, 1H), 7.10 (m, 2H), 4.01 (m, 3H), 3.55 (m, 5H), 3.14 (m, 2H), 2.88 (m, 2H), 2.57 (m, 1H), 2.34 (m, 7H), 1.80 (m, 6H); MS (ES) 495.14 (M+H); 4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-A/-(3-methyl-4-((6R, 95)-6,9- methanooctahydro-1H-pyndo[1,2-ajpyrazin-2-yl)phenyl)pyrimidin-2-amine, compound #279, 1H NMR (CD3OD, 300 MHz): δ 8.34 (m, 1H), 8.21 (s, 1H), 7.98 (m, 1H), 7.53 (m, 2H), 7.32 (m, 1H), 7.08 (m, 2H), 4.03 (s, 1H), 3.96 (m, 2H), 3.63 (m, 5H), 3.12 (m, 3H), 2.59 (s, 2H), 2.37 (s, 3H), 1.92-1.63 (m, 6H); MS (ES) 499.04 (M+H); 4-(6-((1 S,4S)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-y l)py ridin-3-y l)-A/-(3-methyl-4-( 1,4-diazabicyclo[3.2.2jnonan-4-yl)phenyl)pyrimidin-2-amine, compound #280,1H NMR (CD3OD, 300 MHz): δ 8.88 (m, 1H), 8.32 (m, 3H), 7.52 (m, 2H), 7.22 (m, 2H), 6.63 (m, 1H), 4.74 (s, 1H), 3.92-3.81 (m, 2H), 3.58 (m, 4H), 3.43 (m, 4H), 2.65 (m, 2H), 2.43 (m, 2H), 2.36 (s, 3H), 2.13-2.03 (m, 4H); MS (ES) 484.16 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-cyano-4-(3,9-diazabicyclo[3.3,2]decan-10-on-3-yl)phenyl)pyrimidin-2-amine, compound #281,1H NMR ( CD3OD, 300MHz): δ 8.88 (s, 1H), 8.37 (d, 1H), 8.25 (m, 1 H),8.17 (d, 1H), 7.82 (m, 1H), 7.24 (m, 2H), 6.87 (d, 1H), 3.80 (m, 4H), 3.62 (m, 4H), 3.41 (m, 2H), 3.14 (m, 2H), 2.85 (m, 1H), 2.25 (m, 4H), 2.01 (m, 2H), 1.55 (m, 1H); LCMS (m/z): 510.00 (ELSD); 4-(2l2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-cyano-4-(3,9-diazabicyclo[3.3.2jdecan-10-on-3-yl)phenyl)pyrimidin-2-amine, compound #282, Ή NMR ( DMSO, 300MHz): δ 11.5 (s, 1H), 9.87 (s, 1H), 8.73(s, 1H), 8.54 (d, 1H), 228 229 8.24 (s, 1H), 8.03 (d, 1H), 7.84 (m, 2H), 7.46 (d, 1H), 7.31 (d, 1H), 3.41 (m, 1H), 3.11 (m, 1H), 3.02 (m, 2H), 2.68 (m, 1H), 2.11 (m, 4H), 1.83 (m, 1H), 1.46 (s, 6H); LCMS (m/z): 525.01 (MH+); 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-(3-(dimethylamino)-8- azabicyclo[3.2.1]octan-8-yi)phenyl)pyrimidin-2-amine, compound #283,1H NMR (CD3OD, 300 MHz): δ 8.90 (m, 1H), 8.36 (m, 2H), 7.46 (m, 2H), 7.17 (m, 1H), 6.86 (m, 2H), 5.28 (m, 1H), 3.94 (m, 4H), 3.60 (m, 3H), 2.86 (s, 6H), 2.37 (s, 3H), 2.02 (m, 9H), 1.79 (m, 3H) ppm; MS (ES) 515.2 (M+H); 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(3-(morpholin-4-yl)-8- azabicyclo[3.2.1]octan-8-yl)phenyl)pynmidin-2-amine, compound #284, 1H NMR (CD3OD, 300 MHz): δ 8.92 (m, 1H), 8.26 (m, 2H), 7.46 (m, 2H), 7.12 (m, 1H), 6.87 (m, 2H), 3.82 (m, 11H), 3.55 (m, 6H), 2.37 (s, 3H), 2.06 (m, 8H), 1.78 (m, 2H) ppm; MS (ES) 542.3 (M+H); 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/V-(3-methyl-4-(3-(morpholin-4-yl)-8- azabicyclo[3.2.1]octan-8-yl)phenyl)pyrimidin-2-amine, compound #285,1H NMR (CD3OD, 300 MHz): δ 8.93 (m, 1H), 8.25 (m, 2H), 7.47 (m, 2H), 7.13 (m, 1H), 6.88 (m, 2H), 5.28 (m, 1H), 3.84 (m, 11H), 3.54 (m, 6H), 2.37 (s, 3H), 2.08 (m, 8H), 1.79 (m, 2H) ppm; MS (ES) 557.3 (M+H); and 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(3-(dimethylamino)-8- azabicyclo[3.2.1]octan-8-yl)phenyl)pyrimidin-2-amine, compound #286, 1H NMR (CD3OD, 300 MHz): δ 8.89 (m, 1H), 8.27 (m, 1H), 8.21 (m, 1H), 7.45 (m, 2H), 7.08 (m, 1H), 6.84 (m, 2H), 3.87 (m, 2H), 3.77 (m, 2H), 3.54 (m, 3H), 2.84 (s, 6H), 2.37 (s, 3H), 2.02 (m, 9H), 1.77 (m, 3H) ppm; MS (ES) 500.3 (M+H).

TESTING OF THE COMPOUNDS OF THE INVENTION

Exemplary compounds of the invention were tested in the following biological assays for their ability to inhibit JAK activity. BIOLOGICAL EXAMPLE 1 Assay for Ramos B-Cell Line Stimulated with IL-4 B-cells stimulated with cytokine lnterleukin-4 (IL-4) activate the JAK/Stat pathway through phosphorylation of the JAK family kinases, JAK-1 and JAK-3, which in turn phosphorylate and activate the transcription factor Stat-6. One of the genes upregulated by activated Stat-6 is the low affinity IgE receptor, CD23. To study the effect of inhibitors 229 230 on the JAK family kinases, human Ramos B cells are stimulated with human IL-4.

The Ramos B-cell line was acquired from ATCC (ATCC Catalog No. CRL-1596).

The cells were cultured in RPMI 1640 (Cellgro, MediaTech, Inc., Herndon, VA, Cat No. 10-040-CM) with 10 % fetal bovine serum (FBS), heat inactivated (JRH Biosciences, Inc, 5 Lenexa, Kansas, Cat No. 12106-500M) according to ATCC propagation protocol. Cells were maintained at a density of 3.5 x 105. The day before the experiment, Ramos B-cells were diluted to 3.5 x 105cells/mL to ensure that they were in a logarithmic growth phase.

Cells were spun down and suspended in RPMI with 5% serum. 5 x 104 cells 10 were used per point in a 96-well tissue culture plate. Cells were pre-incubated with compound or DMSO (Sigma-Aldrich, St. Louis, MO, Cat No. D2650) vehicle control for 1 hour in a 37 °C incubator.

Cells were then stimulated with IL-4 (Peprotech Inc., Rocky Hill, NJ, Cat No. 200-04) for a final concentration of 50 units/mL for 20-24 hours. Cells were then spun down 15 and stained with anti-CD23-PE(BD Pharmingen, San Diego, CA, Cat No. 555711) and analyzed by FACS (Fluoroescence Activated Cell Sorting). Detection was performed using a BD LSR I System Flow Cytometer, purchased from Becton Dickinson Biosciences of San Jose, California. BIOLOGICAL EXAMPLE 2 20 Primary Human T-cell Proliferation Assay Stimulated with IL-2

Primary human T-cells derived from peripheral blood and pre-activated through stimulation of the T-celi receptor and CD28, proliferate in vitro in response to the cytokine lnterleukin-2 (IL-2). This proliferative response is dependent on the activation of JAK-1 and JAK-3 tyrosine kinases, which phosphorylate and activate the transcription 25 factor Stat-5.

Human primary T cells were prepared as follows. Whole blood was obtained from a healthy volunteer, mixed 1:1 with PBS, layered on to Ficoll Hypaque (Amersham Pharmacia Biotech, Piscataway, NJ, Catalog #17-1440-03) in 2:1 biood/PBS:fico(l ratio and centrifuged for 30 min at 4 °C at 1750 rpm. The lymphocytes at the serum: ficoll 30 interface were recovered and washed twice with 5 volumes of PBS. The cells were resuspended in Yssel’s medium (Gemini Bio-products, Woodland, CA, Catalog #400-103) containing 40 U/mL recombinant IL2 (R and D Systems, Minneapolis, MN, Catalog #202-IL (20 pg)) and seeded into a flask pre-coated with 1 pg/mL anti-CD3 (BD Pharmingen, San Diego, CA, Catalog #555336) and 5 pg/mL anti-CD28 (Immunotech, 230 231

Beckman Coulter of Brea California, Catalog #1M1376). The primary T-cells were stimulated for 3-4 days, then transferred to a fresh flask and maintained in RPM! with 10% FBS and 40 U/mL IL-2.

Primary T-cells were washed twice with PBS to remove the IL-2 and resuspended in Yssel’s medium at 2 x 106 cells/mL. Cell suspension, 50 pL, containing 80 U/mL IL-2 was added to each well of a flat bottom 96 well black plate. For the unstimulated control, IL-2 was omitted from the last column on the plate. Compounds were serially diluted in dimethyl sulfoxide (DMSO, 99.7% pure, cell culture tested, Sigma-Aldrich, St. Louis, MO, Catalog No. D2650) from 5 mM in 3-fold dilutions, and then diluted 1:250 in Yssel’s medium. Compound, 50 pL per well, was added (done in duplicate, two rows per dilution factor) and the cells were allowed to proliferate for 72 hours at 37 °C.

Proliferation was measured using CellTiter-Glo® Luminescent Cell Viability Assay (Promega), which determines the number of viable cells in culture based on quantitation of the ATP present, as an indicator of metabolically active cells. The substrate was thawed and allowed to come to ambient temperature. After mixing the Cell Titer-Gio reagent and diluent together, 100 pL was added to each well. The plates were mixed on an orbital shaker for two minutes to induce lysis and incubated at ambient temperature for an additional ten minutes to allow the signal to equilibrate. Detection was performed using a Wallac Victor2 1420 multilabel counter purchased from Perkin Elmer, Shelton, CT. BIOLOGICAL EXAMPLE 3

Stat5 Assay using Primary Human T-cells or Mouse T-cell Leukaemia CTLL-2 cells Stimulated with IL-2

Stimulation of pre-activated primary human T-cells or mouse CTLL-2 cells with lnterleukin-2 (IL-2) signals to JAK-1 and JAK-3 tyrosine kinases to phosphorylate their immediate downstream target, transcription factor Stat5. The effects can then be quantified using FACS.

Pre-activated human primary T cells are prepared as described in Biological Example 2. CTLL-2 cells are grown in RPMI containing 10% FBS and 10% T-STIM with Con A (Becton Dickinson). CTLL-2 cells or human primary T-cells, which have been washed twice with PBS to remove any residual IL-2, are resuspended in RPMI with 10% FBS medium at 2 x 106 cells/mL 40 pL of T cells and 50 pL of 2X test compound are added to each well of a 96-well round-bottom plate and mixed. After 1 hour incubation with the text compound at 231 232 37 °C, the cells are stimulated by addition of 10 pL per well of 10x IL-2 (400 U/mL) so that the final concentration is 40 U/mL. Cells are incubated further at 37 °C for 15 min. Stimulation is stopped and cells are fixed by addition of 100 pL per well of 3.2% paraformaldehyde and incubation for 10 min at ambient temperature. Following a wash, cells are permeabilized by addition of 150 pL per well of ice-cold methanol and incubation at 4 °C for 30 min. Pelleted cells are washed once with 150 pL per well FACS buffer (PBS + 2% FCS) and stained with 50 pL per well of anti-phospho-Stat5 AlexaFluor488 1:100 in FACS buffer. Following overnight incubation at ambient temperature, the samples are analyzed by FACS after initial wash with FACS buffer. BIOLOGICAL EXAMPLE 4

Stat5 Assay of Unstimulated Human Erythroleukaemia SET2 Cells and Mouse Pre-B Ba/F3 Cells Expressing Human V617F JAK2 Kinase

Human erythroleukaemia SET2 cells and mouse pre-B Ba/F3 cells both express constitutively active form of JAK2 containing mutation V617F in a pseudokinase domain of the enzyme, leading to constitutive phosphorylation of Stat5 transcription factor in the absence of any stimulation. 40 pL ofthe corresponding cell suspension and 50 pL of 2X text compound are mixed together in each well of a 96-well round-bottom plate and incubated for 1 hr at 37 °C. The reaction is stopped by addition of 100 pL per well of 3.2% para-formaldehyde for 10 min followed by permeabilization step with 150 mL of ice-cold methanol at 4 °C for 30 min. After a wash, the cells are stained with 50 pL per well of anti-phospho-Stat5 AlexaFluor488 1:100 in FACS buffer. Following overnight incubation at ambient temperature, the samples are analyzed by FACS. BIOLOGICAL EXAMPLE 5 A549 Epithelial Line Stimulated with IFNy A549 lung epithelial cells up-regulate ICAM-1 (CD54) surface expression in response to a variety of different stimuli. Therefore, using ICAM-1 expression as readout, compound effects on different signaling pathways can be assessed in the same cell type. IFNy up-regulates ICAM-1 through activation ofthe JAK/Stat pathway. In this example, the up-regulation of ICAM-1 by IFNy was assessed.

The A549 lung epithelial carcinoma cell line originated from the American Type Culture Collection. Routine culturing was with F12K media (Mediatech Inc., Lenexa, KS, Cat. No. 10-025-CV) with 10% fetal bovine serum, 100 I.U. penicillin and 100 ng/mL 232 233 streptomycin (complete F12k media). Cells were incubated in a humidified atmosphere of 5% CO2 at 37 °C. Prior to use in the assay, A549 cells were washed with PBS and trypsinized (Mediatech Inc., Cat. No. 25-052-CI) to lift the cells. The trypsin cell suspension was neutralized with complete F12K media and centrifuged to pellet the cells. The cell pellet was resuspended in complete F12K media at a concentration of 2.0x105/mL. Cells were seeded at 20,000 per well, 100 pL total volume, in a flat bottom tissue culture plate and allowed to adhere overnight.

On day two, A549 cells were pre-incubated with test compound or DMSO (control) (Sigma-Aldrich, St. Louis, MO, Catalog No. D2650) for 1 hour. The cells were then stimulated with IFNy (75 ng/mL) (Peprotech Inc., Rocky Hill, NJ, Cat. No. 300-02) and allowed to incubate for 24 hours. The final test compound dose range was 30 μΜ to 14 nM in 200 pL F12K media containing 5% FBS, 0.3% DMSO.

On day three, the cell media was removed and the cells were washed with 200 pL PBS (phosphate buffered saline). Each well was trypsinized to dissociate the cells, then neutralized by addition of 200 pL complete F12K media. Cells were pelleted and stained with an APC conjugated mouse anti-human ICAM-1 (CD54) (BD Pharmingen, San Diego, CA, Catalog #559771) antibody for 20 minutes at 4 °C. Cells were washed with ice cold FACS buffer (PBS + 2% FBS) and surface ICAM-1 expression was analyzed by flow cytometry. Detection was performed using a BD LSR I System Flow Cytometer, purchased from BD Biosciences of San Jose, California. Events were gated for live scatter and the geometric mean was calculated (Becton-Dickinson CellQuest software version 3.3, Franklin Lakes, NJ). Geometric means were plotted against the compound concentration to generate a dose response curve. BIOLOGICAL EXAMPLE 6 U937 IFNy ICAM1 FACS Assay

Human U937 monocytic cells up-regulate ICAM-1 (CD54) surface expression in response to a variety of different stimuli. Therefore, using ICAM-1 expression as readout, compound effects on different signaling pathways can be assessed in the same cell type. IFNy up-regulates ICAM-1 through activation of the JAK/Stat pathway. In this example, the up-regulation of ICAM-1 by IFNy was assessed.

The U937 human monocytic cell line was obtained from ATCC of Rockville Maryland, catalog number CRL-1593.2, and cultured in RPM1-1640 medium containing 10% (v/v) FCS. U937 cells were grown in 10% RPMI. The cells were then plated at a concentration of 100,000 cells per 160 pL in 96 well flat bottom plates. The test 233 234

compounds were then diluted as follows: 10 mM test compound was diluted 1:5 in DMSO (3 pL 10 mM test compound in 12 μί. DMSO), followed by a 1:3 serial dilution of test compound in DMSO (6 pL test compound serially diluted into 12 pL DMSO to give 3-fold dilutions). Then 4 pL of test compound was transferred to 76 pL of 10% RPMI 5 resulting in a 10X solution (100 pM test compound, 5% DMSO). For control wells, 4 pL of DMSO was diluted into 76 pL 10% RPMI.

The assay was performed in duplicate with 8 points (8 3-fold dilution concentrations from 10 pL) and with 4 wells of DMSO only (control wells) under stimulated conditions and 4 wells of DMSO only under unstimulated conditions. 10 The diluted compound plate was mixed 2X using a multimek (Beckman Coulter of

Brea, California) and then 20 pL of the diluted compounds was transferred to the 96 well plate containing 160 pL of cells, which were then mixed again twice at low speeds. The cells and compounds were then pre-incubated for 30 minutes at 37 °C with 5% CO2.

The 10X stimulation mix was made by preparing a 100 ng/ml_ solution of human 15 IFNy in 10% RPMI. The cells and compound were then stimulated with 20 pL of IFNy stimulation mix to give a final concentration of 10 ng/mL IFNy, 10 pM test compound, and 0.5% DMSO. The cells were kept under conditions for stimulation for 18-24 hours at 37 °C with 5% CO2.

The cells were transferred to a 96 well round bottom plate for staining and then 20 kept on ice for the duration of the staining procedure. Cells were spun down at 1000 rpm for 5 minutes at 4 °C, following which the supernatant was removed. Following removal of the supernatant, 1 pL APC conjugated mouse anti-human ICAM-1 antibody was added per 100 pL FACS buffer. The cells were then incubated on ice in the dark for 30 minutes. Following incubation, 150 pL of FACS buffer was added and the cells were 25 centrifuged at 1000 rpm for 5 minutes at 4 °C, following which the supernatant was removed. After removal of the supernatant, 200 pL of FACS buffer was added and the cells were resuspended. After suspension, the cells were centrifuged at 1000 rpm for 5 min at 4 °C. Supernatant was then removed prior to resuspension of the cells in 150 pL FACS buffer. 30 Detection was performed using a BD LSR I System Flow Cytometer, purchased from BD Biosciences of San Jose, California. The live cells were gated for live scatter and the geometric mean of ICAM-APC was measured (Becton-Dickinson CellQuest software version 3.3, Franklin Lakes, NJ). Both % live cells and ICAM-1 expression was analyzed. The assays for the test compounds were carried out in parallel with a control 234 235 compound of known activity. The EC5o for the control compound is typically 40-100 nM. BIOLOGICAL EXAMPLE 7 Fluorescence Polarization Kinase Assay

This assay may be utilized to determine the potency of a compound of the 5 invention against certain JAK kinases and the selectivity of a compound of the invention in inhibiting certain JAK kinase activity in vitro.

Reagents and buffers

Tyrosine Kinase Kit Green (Invitrogen, Cat# P2837)

Acetylated Bovine Gamma Globulin (BGG) (Invitrogen, Cat# P2255) 10 Active JAK1 (Carna Biosctences)

Active JAK2 (Carna Biosciences)

Active JAK3 (Carna Biosciences) TK2 Peptide (Biotin-EGPWLEEEEEAYGWMDF-CONH2) (SynPep Custom Synthesis)

Methods 15 Test compounds were serially diluted in DMSO starting from 500x the desired final concentration and then diluted to 1% DMSO in kinase buffer (20 mM HEPES, pH 7.4, 5 mM MgCI2, 2 mM MnCI2, 1 mM DTT, 0.1 mg/mL acetylated BGG). Test compound in 1% DMSO (0.2% DMSO final) was mixed with ATP and substrate in kinase buffer at ambient temperature. 20 The kinase reactions were performed in a final volume of 20 pL containing peptide substrate and ATP and started by addition of kinase in kinase buffer. The reactions were allowed to proceed at ambient temperature. Final substrate, ATP and enzyme concentrations and reaction times for the different kinase assays are listed in Table 1.

25 TABLE 1: FINAL SUBSTRATE, ATP, ENZYME CONCENTRATIONS AND

REACTION TIMES

Enzyme Enzyme Amount per Reaction Substrate Substrate Concentration ATP Concentration Assay Time JAK1 20 ng TK2 10 μΜ 5 μΜ 20 min JAK2 0.3 ng TK2 10 μΜ 5 μΜ 20 min JAK3 2 ng TK2 10 μΜ 5 μΜ 20 min

The reactions were stopped by adding 20 pL of PTK quench mix containing 235 236 EDTA/anti-phosphotyrosine antibody (1X final)/fluorescent phosphopeptide tracer (0.5X final) diluted in FP Dilution Buffer according to manufacturer’s instructions (Invitrogen). The plates were incubated for 30 minutes in the dark at ambient temperature and then read on a Poiarion fluorescence polarization plate reader (Tecan).

Data were converted to amount of phosphopeptide present using a calibration curve generated by competition with the phosphopeptide competitor provided in the Tyrosine Kinase Assay Kit, Green (Invitrogen). For IC50 determination, the compounds were tested at eleven concentrations in duplicate and curve-fitting was performed by non-linear regression analysis using Matlab version 6.5 (MathWorks, Inc., Natick, MA, USA). BIOLOGICAL EXAMPLE 8 Proliferation Assay

Reagents and Buffers

Dimethyl Sulfoxide (DMSO) (Sigma-Aldrich, Cat No. D2650) (Control)

Iscove’s DMEM, ATCC Catalog #30-2005 1 M HEPES, Celigro Catalog #25-060-CI (100 mL) 100 mM Sodium Pyruvate, Celigro Catalog #25-000-0 (100 mL)

Pennicillin/streptomycin, 10000 U/mL each, Celigro Catalog #30-002-0 (100 mL) RPMI 1640 (Celigro, Cat No. 10-040-CM)

Fetal Bovine Serum (JRH, Cat No. 12106-500M)

Donor Equine Serum, Hyclone Catalog #SH30074.02 (100 mL) 50 μΜ hydrocortisone solution, Sigma Catalog #H6909-10ml (10 mL)

Culture conditions

Ba/F3 V617F cells are maintained and plated in RPMI with 10% FBS. Plating density for these cells is 1 X 105 cells/mL. UKE-1 are maintained and plated in Iscove’s DMEM containing 10% FBS, 10% equine serum, 1% pennicillin/streptomycin and 1 uM hydrocortisone. Plating density for these cells is 0.4 X 106 cells/mL. SET2 cells are maintained and plated in RPMI with 20% FBS. Plating density for these cells is 2 X 105 cells/mL.

CTLL-2 cells are maintained and plated in RPMI containing 10% FBS and 10% T-STIM with Con A (Becton Dickinson). Plating density for these cells is 0.4 X 105 cells/mL 236 237

Methods

The cells were resuspended in a corresponding medium at a required cell density (see above). 100 μ of cell suspension was added to each well of a flat bottom 96 well white plate. The compound was serially diluted in DMSO from 5 mM in 3-fold dilutions, 5 and then diluted 1:250 in the RPMI 1640 medium containing 5% FBS and pen/strep. 100 pL of resulting 2X compound solution was added per well in duplicate and the cells were allowed to proliferate for 72 hours at 37°C.

Proliferation was measured using Cell Titer-Gio. The substrate was thawed and allowed to come to ambient temperature. After removal of top 100 μΐ_ of medium from 10 each well, 100 μΐ_ of the premixed Cell Titer-Gio reagent was added to each well. The plates were mixed on an orbital shaker for three minutes to induce lysis and incubated at ambient temperature for an additional five minutes to allow the signal to equilibrate. The Luminescence was read on the Wallac Plate Reader.

The results of the ability of the compounds of the invention to inhibit JAK2 activity, 15 when tested in the above assay utilizing Ba/F3 V617F ceils, are shown in the following Tables 2-3 wherein the level of activity (i.e., the IC50) for each compound is indicated in Tables 2-3. The compound numbers in Tables 2-3 refers to the compounds disclosed herein as being prepared by the methods disclosed herein: 237 P2

TABLE 2 (Rfy (R2k, ft j £ J &lt;|a-i&gt; IC50 activity: A = &lt;1 pM B = 1to10pM C = &gt;10to 20 pM D = &gt;20 pM Cpd# Compound Name n m R1 R2 R3 R4 R5 icM 1 4-(6-(/V,/V-dimethyiamino)pyridin-3- yl)-/V-(3-methyl-4-((1S,4S)-5-methyl- 2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ch3 A 2 4- (6-(/V,A/-dimethylamino)pyridin-3-yl)-5-methyl-A/-(3-methyl-4-((1S,4S)- 5- methyl-2,5- diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 1 1 H -ch3 -ch3 „= IT ch3 A 3 4-(6-( N, A/-dimethylamino)pyridin-3-yl)-5-trifluoromethyl-A/-(3-methyl-4-((1S,4S)-5-methyJ-2,5-diazabicyclo[2.2.1 ]heptan-2-y0phenyl)pyrimidin-2-amine 1 1 H -ch3 -cf3 ίΎ "•C'N'V ch3 B 4 4- (6-(A/,A/-dimethylamino)pyridin-3-yl)-5-fluoro-A/-(3-methyl-4-((1S,4S)- 5- methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 1 1 H -ch3 -F ίΎ ch3 A 238 239

TABLE 2 (Rfy, (R2)m /R5 IC50 activity: A = &lt;1 μΜ ίΡ T \ Ii B = 1to10pM JL JJ (,a_1) C = &gt;10to20pM R4^ dj D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ιθ50 5 4-(6-(A,/V-dimethylamino)pyridin-3- yl)-5-fluoro-A/-(3-fluoro-4-((1S,4S)-5- methyl-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 1 1 H -F -F HC iT H3C'n^n^ ch3 XT™’ B 6 4- (6-(A/,/V-dimethylamino)pyridin-3-yf)-5-methyl-/V-(3-fluoro-4-((1S,4S)- 5- methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 1 1 H -F -ch3 „= XT ch3 A 7 4-(6-( N, /V-dimethylamino)pyridin-3-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - TX "•C^AX ch3 A 8 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-Z?][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - ςσ ch3 A 239 240

TABLE 2 &lt;R\)n (R2)m nr5 ic50 activity: A = &lt;1 (P T \ H B=1to10pM (,a"1) C = &gt;10to20pM FT in IjT D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 9 4-(4-methyl-3,4-dihydro-2H-pyrido(3,2-b][1,4]oxazin-7-yl)-A/-(3-fluoro-4-((1 S,4S)-5-methy!-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - r°YV ch3 A 10 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrirnidin-2-amine 0 1 H -ch3 - op AT- A 11 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-fluoro-4-((1 S, 4 S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - IT &lt;u A 12 4-(6-((1 S, 4 S)-5-m ethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)-/V-(3-methyl-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XT An-CH3 B 240 241

TABLE 2 (0n (R2)m y. ^R5 ICso activity: A = &lt;1 μΜ IP Τ \ II B = 1to10pM Ji /X (la"1) C = &gt;10to20pM R4^ rT Ijf D = &gt;20 μΜ Cpd # Compound Name n m R1 R2 R3 R4 R5 IC50 13 4-(6-((1S,4S)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)-/V-(3-methyl-4-(4-methylpiperazin-1-yl)phenyl)pyrim!din-2-amine 0 1 H -ch3 - et «.Υ A 14 4-(4-(/V,/V-dimethylamino)phenyl)-/V-(3-methyi-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yi)phenyl)pyrimidin-2-amine 0 1 H -CH3 - tpjv H3%AT ch3 A 15 4-(4-(/V,/V-dimethylamino)phenyl)-A/-(3-f I uoro-4-(( 1 S,4S)-5-methy I-2,5-diazabicyclo[2.2.1 jheptan-2-yi)phenyl)pyrimidin-2-amine 0 1 H -F - H.CY0V ch3 ,T"‘ B 16 4-(6-(4-acetylpi perazi n-1 -yl) py rid in-3-yl)-/V-(3-fluoro-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - XT p/V o A 241 242

TABLE 2 &lt;Pn (R2)m /R5 IC50 activity: A = &lt;1 μΜ ίΡ ϊ \ II Β = Ηο10μΜ A (l3'1) C = &gt;10to20pM N D = &gt;20 μΜ A' Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 19 4-(2,2-dimethyf-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yJ)-/V-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - H3C H,ci ii'" H A 20 4-(2,2-dimethyl-3-oxo-3,4-dibydro-2H-pyrido[3,2-5][1,4]oxazin-7-yl)-A/-(3-methy 1-4-((1 S,4S)-5-methyi-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H3C ΖΛ Η·ρχγ H A 21 4-(1 H-indol-6-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H A 22 4-(1 H-pyrroio[2,3-5]pyridin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - €OV H ' A 23 4-(1H-pyrrolo[2,3-5jpyridin-5-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyt-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - CQV H N A 242 243

TABLE 2 (Rfy, (R2)m /R5 IC50 activity: A = &lt;1 μΜ fp T I II Β = Ηο10μΜ Jl b. JL J {la*1) c = &gt;10 to 20 μΜ R^ TT TjT D = &gt;20 μΜ A1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 24 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3-methy 1-4-(( 1 S,4S)-5-ethy I-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - „c n ch3 ^N^CHj A 25 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(( 1 S,4S)-5-ethyl-2,5-diazabicycio[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - nv u |&lt;?N^CH3 A 26 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V- (3-methyl-4-((1S,4S)-5- ((ethylamino)carbonyl)-2,5- diazabicycloi2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - it X^N 'N op o A 27 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methy 1-4-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h3Hc-V°Y^A' H x6° A 243 244

TABLE 2 (RX (R2)m r5 IC50 activity: A = &lt;1 μΜ il" T \ Π B = 1 Io 10 μΜ λΑ,Υ/yJ (|31) 0 = &gt;10Ιο20μΜ FT Yr Yr D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 28 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-(ethylcarbonyl)-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimtdin-2-amine 0 1 H -ch3 - hW°yY Cr NI H A 29 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido(3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1 S,4S)-5-(methylsulfonyl)-2,5- diazabicyclo[2.2.1 ]heplan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h3c π "•TXT H °v° &gt;YM- A 30 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yi)-A/-(3-methyl-4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2 2.1 ]heptan-2-yi)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H3C n H,ci xt r/Tx H |&lt;?N^CH3 A 31 4-(3’-oxo-3’,4'- dihydrospiro[cyclobutane-1,2'- pyrido[3,2-b][1,4]oxazine]-7'-yl)-/V- (3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - T°rx crY^hr H Y' A 244 245 TABLE 2

<img img-format="tif" img-content="drawing" file="IL207609AD000250.tif" id="idf0050" />

(la-1) IC50 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10to 20 μΜ D = &gt;20 μΜ

Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 32 4-(3’-oxo-3',4'- dihydrospiro[cyclobutane-1,2'-pyrido[3,2-b][1,4]oxazine]-7'-yl)-A/-(3-methyl-4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - H |&lt;?N^CH3 A 33 4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-A/-(3-methyl-4-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 i 1 H -ch3 - €OV H N A 34 4-(1H-pyrro!oi2,3-b]pyridin-5-yl)-/V-(3-methyl-4-((1 S,4S)-5-(2,2,2-trifluoroethyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - CQV H N -,6TCF· A 35 4-( 1 H-pyrrolo[2,3-b] py rid in-5-y l)-/V-(3-methyl-4-«1S,4S)-5-(cyclopropyl)methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimjdjn-2-aniine 0 1 H -ch3 - CQV H IN A 245 246

TABLE 2 (R^)n (R2)m Jk5 IC50 activity: A = &lt;1 μΜ (P Ύ \ H B=1to10pM JL.JJ (la’1) C = &gt;10to20pM R4^ Pr Pr D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R* R3 R4 R5 IC50 36 4-(6-(morphoiin-4-yl)pyridin-3-yl)-A/-(3-methyi-4-((1 S,4S)-5-(2,2,2-trifiuoroethyi)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrirnidin-2-amine 0 1 H -ch3 - xi oU X$TCF· B 37 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1 S, 48)-5-(cyclopropyl)methyl-2,5-diazabicycio[2.2.1 ]heptan-2-yl)phenyi)pyrimidin-2-amine 0 1 H -ch3 - nv u A 38 4-(2,2-dimethyl-3-oxo-3,4-dihydro- 2H-pyrido[3,2-b][1,4]oxazin-7-yi)-A/- (3-methyl-4-((1S,4S)-5- (aminosulfonyl)-2,5- diazabicyclo[2.2.1 ]heptan-2-yi)phenyl)pyrimidin-2-amine 0 1 H -ch3 - Y°xr cAP Η °y;O |&lt;?N' 'NH2 A 39 4-(3-fluoro-2-(morphoiin-4-yl)pyridin-4-yl)-/V-(3-fluoro-4-((1 S,48)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yI)phenyl)pyrimidin-2-amine 0 1 H -F - F B 246 247

TABLE 2 (&lt; (R2)m b5 IC50 activity: A = &lt;1 μΜ ip 7 ί Η B = 1to10pM JI Υΐ J (ίθ’1) C = &gt;10to20pM Fu Yr Yr D = &gt;20 μΜ K1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 40 4-(2-{morpholin-4-yl)pyrimidin-5-yl)-Λ/-(4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 0 H - - nU- oY B 41 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yf)phenyl)pyrimidin-2-amine 0 1 H -ch3 - T'YrA oY A 42 4-(2-(morpholin-4-yl)pyrimidin-5-yl)-A/-(3-methy 1-4-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - °Y B 43 4-(2-(morpholin-4-yl)pyrimidin-5-yl)- A/-(3-fiuoro-4-((1S,4S)-5-methyi-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -F - /A oY A 247 248

TABLE 2 (R/ (R2)m /R5 ICso activity; A = &lt;1 μΜ ip 7 \ Π Β = 1ίθ10μΜ JL AL JLD C = &gt;10to20pM TT TjT D = &gt;20 μΜ 61 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 44 4-(2-((cyclopropyl)carbonylamino)-pyrimidin-5-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - O ,//· A 45 4-(4-(4,5-dihydroth iazol-2-ylcarbamoyl)phenyl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - \^N O B 46 4-(4-(1,1 -dimethylethyl)phenyl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H3C 1h3 A 47 4-(4-(morphohn-4-yl)phenyl)-A/-(3-fluoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine.TFA salt 0 1 H -F - ,/rv B 248 249

TABLE 2 &lt;R^\ (R2(m Ii J Γ J (la-1) IC50 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 48 4-(4- ((methyl)aminocarbonylmethyl)- phenyi)-A/-(3-methyl-4-((1S,4S)-5- methyi-2,5- diazabicycio[2.2.1]heptan-2- yl)pheny?)pyrimidin-2-amine.TFA salt 0 1 H -ch3 - H (&lt;?N'CH3 B 49 4-(4-((cyclopropyl)aminocarbonyl- methyl)phenyl)-A/-(3-methyl-4- ((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1jheptan-2- yl)phenyl)pyrimidin-2-arnine 0 1 H -CH3 - H B 50 4-(6-(methylaminocarbonyl)pyridin-3-yl)-A/-(3-methyJ-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H,A¥OV 0 A 51 4-(7-oxo-5,6,7,8-tetrahydro-1t8-naphthyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine.TFA sail | 0 1 H -ch3 - fTjv H A 249 250

TABLE 2 (R^n (R2U λ5 'θ50 activity: A = &lt;1 μΜ (P T B = 1 to 10 μΜ Jl (la'1) C = &gt;10to20pM FC D = &gt;20 μΜ fV Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 52 4-(5-((morpholin-4-yl)carbonyl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yi)phenyl)pyrimidin-2-amine.Bis TFA salt 0 1 H -CH3 - 6¼ A 53 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b] [ 1,4]oxazin-7-yl)-A/-(3-cyano-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - H A 59 4-(5-methyl-6-(morpholin-4- yl)pyridin-3-yl)-A/-(3-fluoro-4- ((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -F - oU A 60 4-(5-methyl-6-(morpholin-4-yl)pyridiri“3-yi)-A/-(3-methyi-4-((1$,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - op ,,βΥ A 250 251

TABLE 2 (Υη (R2)m vA. p5 IC50 activity: A = &lt;1 μΜ ίΡ T \ N B = 1 to 10 μΜ JLAJkJ (la’1) 0 = &gt;101ο20μΜ rA D _ &gt;2Q μΜ R1 Cpd # Compound Name n m R1 R2 R3 R4 R5 IC50 67 5-methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)pheny()pyrirnidin-2-amine 1 1 H -ch3 -ch3 XY A"’ A 68 5-methyl-4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3‘fluoro-4-((1 S,4S)-5-methy 1-2,5-diazabtcyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 1 1 H -F -ch3 A oU A A 69 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(4-((1S,4S)-5-methyi-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 0 H - - °P PTV Ax/Ay H A B 70 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(3-fiuoro-4-((1 S,4S)-5-methyl-2,5-diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - H A 251 252

TABLE 2 (Rfy, (R2)m IC50 activity: A = &lt;1 μΜ IP ϊ l Η B = 1to10pM (la'1) C = &gt;10to20pM FT D = &gt;20 μΜ f^1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 71 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-h][1,4]oxazin-7-yO-A/-(3-methyl-4-((17?,4/?)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H A 72 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1R,4/?)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyJ)pyrimidin-2-amine 0 1 H -ch3 - ry op A 73 4-(2,2-dimethyl-3-oxo-3,4-dihydro- 2W-pyrido[3,2-b][1,4Joxazin-7-yl)-/V- (3-fluoro-4-((1R,4R)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H F - H XTCH' A 74 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-fluoro-4-((1R,4R)-5-methyi-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H F - XT r"N^N;' &lt;U A 252 253 TABLE 2

<img img-format="tif" img-content="drawing" file="IL207609AD000251.tif" id="idf0051" />

(la-D IC50 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10 to 20 μΜ D = &gt;20 μΜ

Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 75 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methy 1-4-( 1,5,7-trimethy I-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XT A A 76 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ίΎ "./rf’ ch3 At \na4h3 A 77 4-(6-(cyclohexylamino)pyridin-3-yl)-/V-(3-methy 1-4-( 1,5,7-trimethy I-3,7-diazabicyclo[3.3.1 jnonan-3-yf)phenyl)pyrimidin-2-amine 0 1 H -ch3 - CA H Af"' VAch, A 78 4-(6-(cyclohexylamino)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-d!azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - α,σ H A A 79 4-(6-(cyclohexylamino)pyridin-3-yl)-A/-(3-ffuoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-y!)phenyl)pyrimidin-2-amine 0 1 H -F - QA H A A 253 254 TABLE 2

<img img-format="tif" img-content="drawing" file="IL207609AD000252.tif" id="idf0052" />

.5 IC50 activity: A = &lt;1 μΜ B=1to10pM C = &gt;10to20pM D = &gt;20 μΜ

Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 80 4-(6-(benzyl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicycio(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ΧΎ 0+ “ xteCH· A 81 4-(6-(benzyl)pyridin-3-yl)-A/-(3-fluoro-4-((1 S,4S)-5-methy 1-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - XT A 82 4-(5-methyl-6-(morpholin-4- y I) py ri d i n-3-y I )-/V- (3 -f luoro-4-( 1,5,7- trimethyl-3,7- diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -F - A 83 4-(6-(dimethylamino)pyridin-3-yl)-A/-(3“fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 Jnonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -F - HC XT ch3 A 84 4-(4-(dimethylamino)phenyl)-A/-(3-fluoro-4-(1 .SJ-trimethyl-SJ-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -F - .cP" ch3 rter \n_+Ch3 A 254 255

TABLE 2 &lt;R?)n (R2)m /R5 IC50 activity: A = &lt;1 μΜ ίΡ T l· II B = 1to10pM JL /UxJ (la"1) C = &gt;10to20pM FT rl tjT D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 85 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/- (3-fluoro-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3- yl)phenyl)pyrimidin-2-amine 0 1 H -F - iV Y'Y op Ρ», A 86 4-(3,4-dihydro-2H-pyrido[3,2-0][1,4Joxazin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - c°iV H A 87 4-(3,4-d i hydro-2 H-py rid o [3,2-b/[1,4]oxazin-7-yl)-A/-(3-fiuoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - c°ry w H A 88 4-(3,4-dihydro-2/7-pyrido[3,2-0][1,4]oxazin-7-yl)-A/-(3-methyl-4-(1,5,7-trimethyI-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyf)pyrimidin-2-amine 0 1 H -ch3 - N N H A 255 256

TABLE 2 (R^n (R2)m XR5 *θ50 actW A = &lt;1 μΜ (ΛηΙ [ B = 1 to 10 μΜ (la'1) 0 = &gt;1(Ηο20μΜ R4^ ΤΓ TjT D = &gt;20 μΜ R1 Cpd # Compound Name n m R1 R2 R3 R4 R5 ICso 89 4-(3,4-dihydro-2/-/-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyf)pyrimidin-2-amine 0 1 H -F - f°YY H Ρ^ΧΧη3 B 90 4-(6-(benzyl)pyridin-3-yl)-A/-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicycio[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - IT Λ? ‘ A 91 4-(6-(benzyl)pyridin-3-yl)-A/-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -F - XT CPS “ A 92 4-(2-(propyl)aminopyrimidin-5-yl)-A/-(3-methy 1-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H3C / H A 93 4-(2-(propyl)aminopyrimidin-5-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2. 2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - ΝΠτν H3C'^"N^N^ H Y"· A 256 257

TABLE 2 &lt;RT (R2)m Tt5 ICso activity: A = &lt;1 μΜ Pi I II B = 1 to 10 μΜ J* JL JJ (la'1) 0 = &gt;10ΐο20μΜ R4^ ΤΨ PP D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 94 4-(6-(cyclohexylamino)pyridin-3-yl)- A/-(3-trifluoromethyl-4-((1S,4S)-5- methyl-2,5- diazabicyc!o[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -cf3 - O,U H A 95 4-(5-{methyl)sulfonylpyridin-3-yl)-/V-(3-methy!-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyi)pyrimidin-2-amine o ; 1 H -ch3 - XT0"' A 96 4-(6-{dimethylamino)pyridin-3-yl)-/V- (3-trifluoromethyl-4-((1S,4S)-5- methyl-2,5- diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -cf3 - „c XT ch3 A 97 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V- (3-trifluoromethyl-4-((1S,4S)-5- methyi-2,5- diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -cf3 - η* ιχΛ- op „60 A 257 258

TABLE 2 (R^n (R2k, Jl 1 I j &lt;|a-1) R000^0 ICso activity: A = &lt;1 μΜ B = 1to10pM C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R® ICso 98 4-(3,4-dihydro-2H-pyrido[3,2-0][1,4]oxazin-7-yl)-/V-(3-trifluoromethyl-4-((1S,4S)-5-methyl· 2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -cf3 - cTT N N H A 99 4-(6-((2- (cyclopropylsulfonyJ)aminoethyl)-amino)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 6' ο H B 100 4-(6-((2- (cyclopropylsulfonyl)aminoethyl)-amino)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-oxa-2- azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - o' ο η A 101 4-(5-(methyl)sulfonylpyridin-3-yl)-/V-(3-f luoro-4-(( 1S, 4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yi)phenyl)pyrimidin-2-arnine 0 1 H -F - A 258 259

TABLE 2 (B'bn (R2)m ^R5 IC50 activity: A = &lt;1 μΜ ίΡ Ύ I II ,, ., B=1to10pM JI A. L. JJ (|3'υ C = &gt;10 to 20 μΜ R"/ X X D = &gt;20 μΜ A1 Cpd# Compound Name n m R1 R2 R3 R4 Rs IC50 102 4-(5-(methyl)sulfonylpyridin-3-yl)-A/- (3-triffuoromethyl-4-((1S,4S)-5- methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -cf3 - V , „·= χγ N A 103 4-(imidazo[1,2-a]pyridin-6-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicycfo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - xt C'C \z=J &lt;?n'ch° A 104 4-(4-(5-(4- dimethylaminophenyl)oxazoL2- yl)phenyl)-/V-(3-methyl-4-((1S,4S)-5- methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - &lt;vov yi C) H3C-N ch3 Xn'ch° yO B 105 4-(6-methoxy-1 H-indol-2-y 1)-/7-( 3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine 0 1 H -ch3 - h3%XXX υ H A 259 260

TABLE 2 &lt;Rfy&gt; (R2)m X p5 IC50 activity: A = &lt;1 μΜ IP Ύ \ IT B = 1to10pM Jl Λ. I) (la"1) C = &gt;10 to 20 μΜ P. TjT D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 ic5o 106 4-(1 -(3-chlorophenyl)-1 H-pyrazol-4-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - N-ZZ B 107 4-(1-methylbenzimidazol-6-yl)-A/-(3-methyl-4-((1 S,4 S)-5-m ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h3c CO" A 108 4-(5-cyano-1 H-indol-2-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - "cxx&gt; H A 109 4-(1-{4-fluorophenyl)-1H-pyrazol-4- yl)-A/-(3-methyl-4-((1S,4S)-5-methyl- 2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 0 F A 260 261

TABLE 2 (R^n (R2)m J45 IC50 activity: A = &lt;1 μΜ (P T \ Η Β = Ηο10μΜ ALAk /AJ (la'1) C = &gt;10to20pM R4^ rT TsT D = &gt;20 μΜ R1 Cpd# Compound Name n m R4 R2 R3 R4 R5 Ιθ50 110 4-(6-(morpholin-4-yl)pyndin-3-yl)-/V-(3-methyl-4-(7-azabicyclo[2.2.1 ]heptan-7-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - jprv &lt;U Y7 B 111 4-(6-cyanopyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ίΥ ncAA B 112 4-(6-cyanopyridin-3-yl)-A/-(3-methyl-4-(7-azabicyclo[2.2.1 ]heptan-7-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - yY Y7 B 113 4-(2-oxoindolin-5-yl)-A/-(3-methyl-4((1S,4S)-5-methyi-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - °YOV H A 114 4-(5-cyanopyridin-3-yl)-/V-(3-methyl-4((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ,Υ"· B 261 262

TABLE 2 (R^n (R2)m r5 IC50 act’v‘ty; A = &lt;1 μΜ (P T Γ II B = 1 to 10 μΜ JppL J^JJ (la’1) 0 = &gt;10ίο20μΜ PP PP D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 Ιθ50 115 4-(6-( 1 H-tetrazol-5-yl)pyridin-3-yl)-A/-(3-methyl-4((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h iP γκ A A &lt; w N N"N c 116 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-cyano-4-((1S,4S)-5-acetyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - jlY oP P“· A 117 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-cyano-4-((1S,4S)-5-methylsulfonyl-2,5-diazabicycfo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - xT PP^N op A 118 4-(6-(morphoHn-4-yl)pyridin-3-yl)-/V-(3-cyano-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - rp PP^rP op xsf"· A 262 263 TABLE 2

P (R2)m Vx IC50 activity: A = &lt;1 μΜ ίΓ T \ Η B = 1to10pM J* JL JL U (!a"1) C = &gt;10 to 20 μΜ FC AT TjT D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 119 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-cyano-4-(( 1 S,4S)-5-cyclopenty I-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - jV PXP A 120 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methy 1-4-(1,4-diazabicyclo[3.2.1 ]octan-4-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - xP p. A 121 4-(2-oxoindolin-5-yl)-/V-(3-methyl-4-(1,4-diazabicyclo[3.2.1 joctan-4-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - °pov H P" XP' A 122 (1-methylbenzimidazol-6-y!)-/V-(3- methyl-4-(1,4- diazabicyclo[3.2.1]octan-4- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H3C P A 123 4-(imidazo[1,2-a]pyridin-6-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.1 ]octan-4-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ζ/ P A 263 264

TABLE 2 (R^n (R2)m V\ IC50 activity: A = &lt;1 μΜ ίΡ T \ Η Β = 1ίο10μΜ (la'1) C = &gt;10to20pM D = &gt;2θ μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 Ιθ50 124 4-(2H-benzo[P][1,4Joxazin-3(4/7)-on-6-yl)-A/-(3-fiuoro-4-((1 S,4S)-5-methyl-2,5- diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - χσ AXCH3 A 125 4-(2,2,4-tri methyl-3-oxo-3,4-d i hyd ro-2H-pyrido[3,2-6][1,4]oxazin-7-yl)-A/-(3-methy 1-4-(( 1 S,4S)-5-methy I-2,5-diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H3C x&gt; "A IT ch3 ^N'CH3 A 126 4-(2,2,4-tri methyl-3-oxo-3,4-di hyd ro- 2H-pyrido[3,2-Z&gt;][1,4]oxazin-7-yl)-A/- (3-fluoro-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -F - h3HcP°Y%A ch3 &lt;Xn'CH3 A 127 4-(5-(3-methylpiperidin-1-yl)pyrazin-2-yl)-A/-(3-fluoro-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pynmidin-2-amine 0 1 H -F - ifV B 264 265

TABLE 2 A" &lt;r2!"&gt; V\ A5 IC50 activity: A = &lt;1 μΜ ίσ i \ il B=1to10pM Jl J. JL JJ (la"1) C = &gt;10 to 20 μΜ rA D = &gt;20 μΜ f^1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 128 4-(4-(i-butylcarbonylamino)phenyl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - H3C jtNLL ' h43 h A A 129 4-(4-(i-butylcarbonylamino)phenyl)-A/-(3-methy 1-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - hsC JtN JO H43 ” A"' A 130 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,43oxazin-7-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - An &lt;AV H A"’ A 132 4-(6-(acetamido)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyi)pyrimidin-2-amine 0 1 H -ch3 - 3 H A"’ A 265 266

TABLE 2 X" (R2)m /H5 IC50 activity: A = &lt;1 μΜ [p T I Η B = 1to10pM JI PL PP P &lt;la'1) C = &gt;10to20pM Fv rv Pr D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 133 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-A/-(3-fluoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - Β 134 4-(4-((pyridin-2-yl)aminocarbonyl)phenyl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - cyP A 135 4-(4-(methylsulfonylamino)phenyl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - ° Pv H3C-S. ΛΧ ο H A 136 4-(4-(methylsulfonylamino)phenyl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ° iP" h3cTn-AX 0 H A 266 267 TABLE 2 (R^)n (R2)m J&lt;5 IC50 activity: A = &lt;1 μΜ (Λ Τ ΓΗ B = 1to10pM JJ J. JL JJ {la'1) C = &gt;10to20pM R4^ NT XT D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 137 4-(2,2-di methyl-3-oxo-3,4-d i hyd ro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 0 H - - H3C XW οΛνΛν^ Η A 139 4-(4-(3-cyclopropylureido)phenyl)-A/-(4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 0 H - - Η Η A 141 4-(6-(2-(morpholin-4-yt)acetamido)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pheny!)pyrimidin-2-amine 0 1 H -ch3 - Ο ^ν_ΛνΛΥ Η A 142 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-/V-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yJ)phenyl)pyrimidin-2-amine 0 · ' 0 H - - Η Β 267 268

TABLE 2 (R^n (R2)m ps IC50 activity: A = &lt;1 μΜ fp T \ (I B = 1to10pM Jl Jl (la'1) C = &gt;10to20pM fv IT ΊΡ D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 Rs IC50 143 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-/V-(3-fluoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - H B 147 4-(6-(acetamido)pyridin-3-yl)-A/-(3-m ethyl -4-(( 1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - O 3 H A 148 4-(6-aminopyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-ethylcarbonyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H2N^ &lt;&gt;NPCH3 A 149 4-(6-(acetamido)pyridin-3-yl)-/V-(3- methyl-4-((1S,4S)-5-ethylcarbonyl- 2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H X-Ο A 150 4-(6-aminopyridin-3-yl)-/V-(3-methyl-4-(( 1S, 4S)-5-methylsu lfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h2NA^ %&gt;° „6"CHl A 268 269

TABLE 2 &lt;Rfy&gt; (R2)m Pa A5 IC50 activity: Α = &lt;1μΜ ίΡ T I Υ B = 1to10pM J* PL JL U (la"1) C = &gt;10to20pM Fn rP PjP D = &gt;20 μΜ P Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 151 4-(6-(methylsulfonylamino)pyridin-3- yl)-/V-(3-methyl-4-((1S,4S)-5-methyi- 2,5-diazabicyclo[2.2.1]heptan-2- yi)phenyl)pyrimidin-2-amine 0 1 H -ch3 - O H3C-,PNAY Ο H A"’ B 152 4- (6-(2-(dimethylarnino)acelamido)-pyridin-3-yi)-A/-(3-rnethyl-4-((1S,4S)- 5- methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - CH3 O N^P h3c^N^P 3 H A""' A 153 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(3-fluoro-4-((1S,4S)-5-rnethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yi)phenyl)pyrimidin-2-amine 0 1 H -F - O N^rP h3c&lt;nAJ Ο H A B 155 4-(6-(morpholin-4-yl)pyridin-3-yI)-A/-(4-(8-methyl-3,8-diazabicyclo[3.2.1 joctan-3-yl)phenyf)pyrimidin-2-amine 0 0 H - - ΓΤ op A 156 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(4-(8-methyl-3,8-diazabicyclo[3.2.1 ]octan-3-yl)phenyl)pyrimidin-2-amine 0 0 H - - ο ν'ΎΡ h3&lt;ppnAp ο H A"’ B 269 270

TABLE 2 (RY (R2)m y. r5 IC5o activity: A = &lt;1 μΜ ίΚ T \ II B = 1 to 10 μΜ Jl JL JL U (la"1) C = &gt;10 to 20 μΜ FY rv IjT D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 157 4-(2,2-dimethyl-3-oxo-3,4-dihydro- 2H-pyrido[3,2-h][1,4]oxazin-7-yl)-A/- (4-(8-methyl-3,8- diazabicyclo[3.2.1 ]octan-3-yl)phenyl)pyrimidin-2-amine 0 0 H - - H X"'CHI A 158 4-(6-aminopyndin-3-yl)-/V-(4-{8-methyl-3,8-diazabicyclo[3.2.1 ]octan-3-yl)phenyl)pyrimidin-2-amine 0 0 H - - A 159 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V- (3-methyl-4-(1,4- diazabicyclo[3.2.2]nonan-4- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ίΎ op A 160 4-(2,2-dimethyl-3-oxo-3,4-dihydro- 2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V- (3-methyi-4-(1,4- diazabicyclo[3.2.2]nonan-4- yl)pheny!)pyrimidin-2-amine 0 1 H -ch3 - h3c-y°y^A' H A 270 271

TABLE 2 &lt;R^n (R2L· IC50 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 1C 50 161 4-(4-((pyridin-2- yl)aminocarbonyl)phenyl)-A/-(3- methyl-4-(1,4- diazabicyclo[3.2.2]nonan-4- yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - o-J A 162 4-(4-(acetamido)phenyl)-A/-(4-(8-methyi-3,8-diazabicyc!o[3.2.1 joctan-3-yl)phenyl)pyrimidin-2-amine 0 0 H - - o Η3γΑν^ 3 H A 163 4-(2-(diethylamino)thiazof-4-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H3C^ \ N&lt;V H3c-^N J; J A 164 4-(2-(diethyiamino)thiazol-4-yl)-A/-(3-fluoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - h3c-^ h3c^nAz jr 3 A 165 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1 joctan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h3c ~ s h3c-V γ+Λ cAA? H +-N'CH3 -\nV A 271 272

TABLE 2 (Rbn (R2)m /R5 IC50 act'v'ty: A = &lt;1 μΜ in Ύ r N Z, B = 1to10pM J* PL L. U C = &gt;10to20pM ΤΓ TjT D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 166 4-(6-(morpholin-4-yi)pyridin-3-yl)-A/-(3-methyl-4-(8-methyi-3,8-diazabicyclo[3.2.1 ]octan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - &lt;U A 167 4-(6-(methylsulfonylamino)pyridin-3-yl)-A/-(3-methyI-4-(8-methyl-3,8-diazabicyclo[3.2.1 joctan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 0 II f| H3C-^nA^I ο H A 168 4-(4-(/-butylcarbonylamino)phenyl)-A/-(3-methyl-4-(8-methyl-3,8-diazabicyclo[3.2.1 ]octan-3-yl)pheny0pyrimidin-2-amine 0 1 H -ch3 - H3C^Xn-O hPh3 h A""' A 169 4-(1H-pyrrol-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - xX"· B 170 4-(1 H-pyrrol-3-yl)-A/-(4-((1 S,4S)-5-methyl-2,5- diazabtcyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 0 H - - A""' B 272 273

TABLE 2 (RX (R2)m Vk t?5 iC50 activity: A = &lt;1 μΜ ίΡ I \ Η B = 1to10pM J* PL P. ϋ (la'1) C = &gt;10to20pM R Pr PP D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 171 4-(1 /-/-pyrrol-3-yl)-A/-(3-trifluoromethy 1-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-am!ne 0 1 H -cf3 - opH3 A 172 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-trif I uoromethyi-4-(( 1 S,4 S)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -cf3 - H3C H3PP" H A 173 4-(6-ethoxypyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yi)phenyi)pyrimidin-2-amine 0 1 H -ch3 - IT H3C Ο N A 174 4-(6-ethoxypyridin-3-yl)-A/-(3-fluoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - H3C 0 N B 175 4-(2-(dimethylamino)thiazol-4-yl)-/V-(3-methyl-4-((1S,4S)-5-methyI-2,5-diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h3c ., J ' N v «J/f' B 273 274

TABLE 2 (R^n (R2)m JX5 IO50 activity: A = &lt;1 μΜ ίΡ Ύ \ Η B = 1to10pM {la’1) C = &gt;10to20pM R4^ PP PP D = &gt;20 μΜ R1 Cpd # Compound Name n m R1 R2 R3 R4 Rs IC50 176 4-(2-(dimethylamino)thiazol-4-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - h3c m hZXT B 178 4-(5-(morpholin-4-yl)pyrazin-2-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 ; H -CH3 - .N. V Jt J P XT”’ B 179 4-(5-(morphoiin-4-yl)pyrazin-2-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - IT ΡνΡ^ op χτ“· B 181 4-(4-( 1 -ethoxyethyl)phenyl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ίΎ h3cvo^PPP ch3 .5"“· B 182 4-(4-(1-ethoxyethyl)phenyl)-A/-(3-fiuoro-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - iT h3c^oPV ch3 XT”’ B 274 275

TABLE 2 (RY (R2)m p5 IC50 activity: A = &lt;1 μΜ ίρ T I II B=1to10pM JIAL (la"1) C = &gt;10to20pM R^V V+Y D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 183 4-(6-(dimethylamino)pyridin-3-yl)-/V-(4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 0 H - - iY η·%λ,ζ ch3 A 184 4-(6-(morpholin-4-yl)pyridin-3-yi)-/V-(4-((1 S,4S)-5-methy 1-2,5-diazabicyc!o[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 0 H - - iY r ' n^n' op A 185 4-(4-methyl-3,4-d i hyd ro-2/7- pyrido[3,2-Z&gt;J[1,4]oxazin-7-yl)-A/-(4- ((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 0 H - - C°IY N N ch3 A 186 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-/V-(3-methy 1-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - o/^ch3 p# H γ/Η· A 275 276

TABLE 2 (Rfy. &lt;R2)m T?5 IC50 activity: A = &lt;1 μΜ fp T l· ll B=1to10pM JAY. {,a"1) C = &gt;10to20pM Fc Yr Yr D = &gt;20 μΜ fV Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 187 4-(6-(c/'s-2,6-dimethylmorphoiin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - V ch3 Y' A 188 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - rx H Y”’ A 189 4-(6-(2- (dimethylamino)methylmorpholin-4- yl)pyridin-3-yl)-/V-(3-methyl-4- ((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - Ύ ch3 A 190 4-(6-(piperidin-1-yl)pyridin-3-yl)-/V-(3-methy 1-4-(( 1 S,4S)-5-methy I-2,5-diazabicycJo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - rx A 276 277

TABLE 2 (R^)n (R2)m d5 IC50 activity: A = &lt;1 μΜ IP T I Pi B = 1to10pM JI PL JPP (,a‘1) C = &gt;10to20pM Fv θ = &gt;2θ μΜ I1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 191 4-(6-(3-(aminocarbonyl)piperidin-1-yl)pyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - X H2N"X) B 192 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyi-4-((1S,4S)-5-methylsulfonyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XT A 193 4-(4-methy 1-3,4 -dihydro-2/7-pyrido[3,2-b]i1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4S)-5-methylsulfonyl-2,5-d iazabicycio[2.2.1 jhepta n-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - cXX N N ch3 p'“· A 194 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - fX op A 277 278

TABLE 2 (RXn (R2)m ^R5 IC50 activity: A = &lt;1 μΜ [ΛΥ I ll Β=11ο10μΜ bi JL U C = &gt;10 to 20 μΜ FT Yr Yr D = &gt;20 μΜ fV Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 195 4-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-/\/-(3-methyl-4-{(1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - s-V ch3 33° A 196 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyf-4-((1S,4S)-5-ethylcarbonyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - Yn oY 3SY A 197 4-(6-(2-(morpholin-4-yl)ethyl)aminopyridin-3-yl)-A/-(3-methy 1-4-(( 1 S,4S)-5-ethy Icarbony I-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - Ο P7 H &lt;YCHi B 198 4-(6-(3- dimethylamino)propylaminopyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H C _ IT ch3 h &lt;Xn'CH3 B 278 279

TABLE 2 (RY (R2)n&gt; IC50 activity: A = &lt;1 μΜ |pX 1 11 Β = Πο10μΜ XL JL· Jl (Ιθ"1) C = &gt;10to20pM &gt;r TjT D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ic50 199 4-(6-{morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-amidino-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine. TFA salt 0 1 H -ch3 - /y &lt;U NH (&lt;?Xnh2 TFA B 200 4-(6-(3-ethoxypropyl)aminopyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - o^ch3 ikyk H A 201 4-(6-c/s-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-A/-{3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - V ch3 .6° A 202 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - fY H A 279 280

TABLE 2 (R^)n (R2)m /R5 'θ50 activity: A = &lt;1 μΜ ίΡ T I If Β=Ήο10μΜ J! JL JL y &lt;la"1) C = &gt;10to20pM FU NT Tjf D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 1C5O 203 4-(6-(3- dimethylamino)propylaminopyridin-3-yl)-/V-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - _____XX CH3 H xt A 204 4-(6-( 1,4-oxazepan-4-yl)pyridin-3-yl)-A/-(3-meihyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 , H -ch3 - XT ! N N O xt A 205 4-(6-(morpholin-4-yi)pyridin-3-yl)-/\/-(3-methyl-4-((1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XX &lt;XXX A 206 4-(6-( 1,4-oxazepa n-4-yl) pyridi n-3-y l)-A/-(3-methyl-4-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XT 0 ” 0-/ A 280 281

TABLE 2 (R2)m j^5 ic50 activi{y: A = &lt;1 mm ip 7 1 H B = 1 to 10 μΜ J· JL JL JJ (ta'1) C = &gt;10to20pM R4^ ΤΓ Ijf D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ic50 207 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2“d][1,4]oxazin-7-yi)-A/-(3-methyl-4-(1,5,7-trimethy!-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - h-T°xt οΛνΛνζ&gt; H PL A 208 4-(2,2-di methyl-3-oxo-3,4-d i hyd ro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-fluoro-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 }nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -F - η·Τ°ϊυ H Ταη3 ,AT, B 209 4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4Joxazin-7-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - X°T? H XO'“· A 210 4-(3-oxo-3,4-dihydro-2A7-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1 S,4S)-5-oxa-2- azabicycfo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - /XT H ,,6° A 281 282

TABLE 2 (R^n (R2)m IC5o activity: A = &lt;1 μΜ ίΡ I \ II B = 1to10pM a1) C = &gt;10to20pM R TV *|T D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 Ιθ50 211 4-(6-(3-ethoxypropyi)aminopyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yi)phenyl)pyrimidin-2-amine 0 1 H -ch3 - &lt;Pch3 PP H Λρ \ΝχΛη, A 212 4-(6-((2S, 6/7)-2,6- dimethylmorpholin-4-yl)pyridin-3-yl)- A/-(3-methyl-4-(1,5,7-trimethyl-3,7- diazabicyclo[3.3.1]nonan-3- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - V ch3 Λρ A 213 4-(6-(propylamino)pyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ΓΧ H Λ”'“· A 214 4-(6-(3- dimethylamino)propylaminopyridin-3-yl)-/V-(3-methyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyi)pyrimidin-2-amine 0 1 H -CH3 - ΓΫ h3cn-^nTnX ch3 h ΛΡ \n^PCh3 B 282 283

TABLE 2 (R$n (R2)m Vk IC50 act'v*y; A = &lt;1 μΜ Γ Τ \ \\ Β = 1ίο10μΜ Jl JL L. Jl (la'1) C = &gt;10 to 20 μΜ R4^ ΥΓ ητ D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 215 4-(6-((1 S,4S)-2-oxa-5-azabtcyclo[2.2.1 ]heptan-5-yl)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - £Y A 216 4-(6-((1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yi)pyridin-3-yi)-A/-(3-methyl-4-((1S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - xY A 217 4-(6-(3-rnethylbutyJ)aminopyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-d iazabicyclo[2.2.1 ] heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - ΧΥίΥ H3C N N H A 218 4-(6-(3,3- dimethylbutyl)aminopyridin-3-yl)-/\/- (3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2- yi)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 3 H X6Y A 283 284

TABLE 2 (R^n (R2)m Y\. A5 IC5o act'vity: A = &lt;1 μΜ fP T I II Β = 1ίο10μΜ AaJAA (la’1) C = &gt;10to20pM rA AT Υ/ D = &gt;2θ μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 219 4-(6-(2- methoxyethyl)(methyl)aminopyridin-3-yl)-/V-(3-methy 1-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - IT h3c n n ch3 A""’ A 220 4-(6-(2- methoxyethyl)(methyl)aminopyridin-3-y l)-A/-(3-methyl-4-(( 1 S,4S)-5-oxa-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H ; -ch3 - XT H3C N N ch3 A A 221 4-(6-(2- methoxyethyl)(methyl)aminopyridin-3-yl)-A/-(3-meihyl-4-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1 ]nonan-3-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - iY ch3 Ay A 222 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((1S,4/7)-2-azabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XT A/ °A A A A 284 285

TABLE 2 (R+_ &lt;R% ji J JX Jf (la-1) ICS0 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 223 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-((1S,4R)-2-azabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H Y A 224 4-(2,2-dimethyJ-3-oxo-3,4-dihydro-2H-pyrido(3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1 ]heptan-5-yJ)phenyl)pyrimidin-2-amine and 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1 ]heptan-6-yl)phenyl)pyrimidin-2-amine (68:31) 0 1 H -ch3 - h^V°'Ptv οΑΛυ H ApN-S-CH3 ° and A,,° o' xch3 A 285 286

TABLE 2 (Rfy (R2)m r5 IC50 activity: A = &lt;1 μΜ ίΡ T I II B = 1to10pM J· J. kJ) (la’1) C = &gt;10to20pM fv IT Ijf D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 Rs ICso 225 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1 Jheptan-5-yl)phenyl)pyrimidin-2-amine and 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-(2-methylsulfonyl-2-azabicyclo[2.2.1 ]heptan-6-yl)phenyl)pyrimidin-2-amine (85:15) 0 1 H -ch3 - 0 A and oZ/ "ch3 B 226 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-5][1,4]oxazin-7-yl)-A/-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1 ]heptan-5-yl)phenyl)pyrimidin-2-amine 0 0 H - - Pit H ^ApN-S-CH3 B 227 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/- (4-(2-methylsulfonyf-2- azabicyclo[2.2.1Jheptan-5- yi)phenyl)pyrimidin-2-amine 0 0 H - - IT oP ApN-S-CH3 ρΡΡ o A 286 287

TABLE 2 A (R2)m JR5 IC50 activity: A = &lt;1 μΜ fp 1 1 H B=1to10pM J1 0L JL JJ &lt;la"1) C = &gt;10to20pM tr XjX D = &gt;20 μΜ R’ Cpd# 228 Compound Name n m R1 R2 R3 R4 Rs Ιθ50 4-(2,2-dimethyi-3-oxo-3,4-dihydro-2/7-pyrido[3)2-b][1,4]oxazin-7-yl)-/V-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1 ]heptan-6-yl)phenyl)pyrimidin-2-amine 0 0 H - - H3C ΖΛ AIT H o=s-° ch3 A 229 4-(6-(morphofin-4-yl)pyridin-3-yl)-A/-(4-(2-methylsulfonyl-2-azabicyclo[2.2.1 ]heptan-6-yl)phenyl)pyrimidin-2-amine 0 0 H - - XT XYT &lt;U o=s-° ch3 B 230 4-(6-(thiamorpholin-4-yl)pyridin-3-y l)-/V-(3-methy 1-4-(( 1 St4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XT 0 A 231 4-(6-(morpholin-4-yJ)pyridin-3-yl)-A/-(3-methy 1-4-(( 1 S,4S)-5-mei hyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimjdin-2-amine 0 1 H -ch3 - XT' χΑΎ &lt;U A 287 288

TABLE 2 &lt;R% R " IC50 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 232 4-(1 -(py rid i n-4-yl)-1 W-indoJ-5-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 0 P A 233 4-(1-(pyridin-4-yl)-1H-indol-5-yl)-A/-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -F - ca ό P aa A 234 4-(1-(pyridin-4-yl)-1H-indol-5-yl)-A/-&lt;3-methyl-4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ca ό P I&lt;Cn^ch3 A 288 289

TABLE 2 (RX_ {R2L· IC50 activity: A = &lt;1 μΜ B = 1 tolOpM C = &gt;10 to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC54) 235 4-( 1 -(py ridi n-4-yl)-1 H-indol-5-yl)-W-(S-methyM-iilS^SJ-S-isobutyl^.S-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - xov A CH3 A 237 4-(7-oxo-5,6,7,8-tetrahyd ro-1,8-naphthyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-methylsulfonyi-2t5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - m Cr bJ N H A' A 238 4-(6-(propylamino)pyridin-3-yi)-/V-(3- methyl-4-((1S,4S)-5-methylsulfonyl- 2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - XT H %&gt;° A A 239 4-(3-oxo-3,4-dihydro-2H- benzo[Z?][1,4]thiazin-7-yl)-W-(4- ((1S,4S)-5-methyl-2,5- diazabfcyclo[2.2.1]heptan-2- yi)phenyl)pyrimidin-2-amine 0 0 H - - aJ A" A 289 290

TABLE 2 iRY (R2)m p5 IC50 activity: A = &lt;1 μΜ (P T I II B = 1to10pM J! P. JL J) C = &gt;10 to 20 μΜ PP PP D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 240 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyc!o[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - P H ^n'CH3 A 241 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[Z&gt;][1,4Joxazin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-methylsulfonyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H %&gt;O X" "Hl A 242 4-(2-oxo-2,3,4,5-tetra hydro-1H-benzo[b]azepin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 0 H ,XH· A 243 4-(2-oxo-2,3,4,5-tetrahydro-1 H-benzo[b]azepin-7-yl)-/V-(3-methyi-4-((1 S,4S)-5-methylsulfonyf-2t5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - .,;o‘ 0 H %&gt;O X' A 290 291

TABLE 2 (Rfy (R2)m x5 IC50 activity: A = &lt;1 μΜ (P T \ Η B = 1to10pM (l3_1) C = &gt;10to20pM P D = &gt;20 pM A1 Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 244 4-(2,2-d imethyl-3-oxo-3,4-di hyd ro- 2H-benzo[h3[1,4]oxazin-7-yl)-A/-(3- methyl-4-((6R,9S)-6,9- metha nooctahydro- 1/7-pyrido[1,2- a]pyrazin-2-yl)phenyl)pyrimidin-2- amine 0 1 H -ch3 - Pr H X5 A 245 4-{6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-methyl-4-((6/?,9S)-6,9-methanooctahydro-1 /7-pyrido[1,2-a]pyrazin-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - fp oP ,χ A 246 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-(1-methylethyl)-2,5- diazabicyclo[2.2.1 Jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - οΛνΛΧ Η ch3 X CHI A 247 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b][1,4]oxazin-7-yl)-/V-(3-methyl-4-((1S,4S)-5-cyclopropyl-2,5-diaza bicyclo[2.2.1] hepta n-2-yl)phenyl)pyrimjdin-2-amine 0 1 H -ch3 - οΡ/ Η Ρ A 291 292

TABLE 2 (T? (RT XXXF &lt;ia'i&gt; IC50 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 248 4-(2,2-dimethyl-3-oxo-3l4-dihydro-2H-pyrido[3,2-b]ί1,4]oxazin-7-yl)-Λ/-(3-chloro-4-{(1S,4S)-5-methyl-2,5-diazabicycJo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -Cl - H3C zx "TXT H ^n-CH3 A 249 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyridoi3,2-b][1,4]oxazin-7-yl)-A/-(3-chloro-4-((1S,4S)-5-(methylsulfonyl)-2,5- diazabicyclo[2.2.1 ]heptan-2-yJ)phenyl)pyrimidin-2-amine 0 1 H -Cl - Ύχχ H Οχ zO - A 250 4-(2,2-dimethyl-3-oxo-3,4-dihydro- 2H-pyrido[3,2-b}[1,4]oxazin-7-yl)-A/- (3-methy!-4-((1S,4S)-5-cyclopentyl- 2,5-diazabicyclo[2.2.1]heptan-2- yl)phenyf)pyrimidin-2-amine 0 1 H -ch3 - h3c o hicxxx ASP H Y A 251 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(S-methyM-KIS^sj-b-acetylYb-diazabicyclo(2.2.1 ]heptan-2-yl)phenyl)pyrimidtn-2-amine 0 1 H -ch3 - Ax H 0 &lt;Qn'^'ch3 A 292 293

TABLE 2 (R^)n (R2)m JR5 ICso activity: A = &lt;1 μΜ ίΡ ϊ \ Η B = 1to10pM apL.PP J (ΐ3’υ C = &gt;10to20pM R' Pr Pr D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 252 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2/7-pyrido[3,2-b](1,4]oxazin-7-yl)-/V-(3-methy 1-4-( 1,4- diazabicyclo[3.2.1 ]octan-4-yi)phenyl)pyrimidin-2-amine 0 1 H -ch3 - iVw (TV ¥ H P" \P; A 253 4-(5-(1- methylethoxy)carbonylpropyl-6-aminopyridin-3-yl)-A/-(3-methyi-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine; 0 1 H -ch3 - CH3° wV fON'CH3 A 254 4-(6-(morpholin-4-yl)pyridin-3-y!)-/V-(3-methyl-4-(( 1 S,4S)-5-cyclopropy I-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyi)pyrimidin-2-amine 0 1 H -ch3 - /7 o TP A 255 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-chloro-4-((1S,4S)-5-methyl-2,5-diazabicycio[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -Cl - jQv oP pr A 293 294

TABLE 2 (RY (R2)m J35 IC50 activity: A = &lt;1 μΜ ίΡ Ϊ ill B = 1to10pM J· JL &lt;la'1) C = &gt;10to20pM R*^ Τ[Γ D = &gt;20 μΜ Cpd# 256 Compound Name n m R1 R2 R3 R4 R5 ΙΟβο 4-(2-(trifluoromethyl)pyridin-4-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yJ)phenyi)pyrimidin-2-amine 0 1 H -ch3 - rf’ CF3 γΡ A 257 4-(6-(morpholin-4-yl)pyndin-3-yl)-A/-(3-chloro-4-((1S,4S)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -Cl - XY Οχ /0 A 258 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-/\/-(3-chloro-4-((1S,4S)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -Cl - Οχ /0 - Β 259 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(3-chloro-4-((1S,4S)-5-acetyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -Cl - op ο ,&lt;ΡνΎη3 A 294 295

TABLE 2 ya Xj (,a'i) IC5, o activity: A = &lt;1 μΜ B = 1to10pM C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 260 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-chloro-4-((1S,4S)-5-acetyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -Cl - Y O (OAch, χΥ B 261 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-y!)phenyl)pyrimidin-2-amine 0 1 H -ch3 - CY Y A 262 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-((1 S,4S)-5-cyclopentyl-2,5-diazabicyclo[2.2.1 Jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - Y ,D Y A 263 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-chloro-4-((1 S,4S)-5-(1-methylethyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - rY CH3 33 CHI A 295 296

TABLE 2 &lt;RT (R2K f| 1 i Jj (la-1) IC50 activity: A = &lt;1 μΜ B = 1to10pM C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 264 4-(6-((1 S,4S)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-yl)pyridin-3-yl)-/V-(3-methyl-4-((1 S,4S)-5-(methylsulfonyl)-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - rX &amp;amp; “ Ox ZO XT “· A 265 4-(6-((1 R,4R)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-yl)pyridin-3-yl)-A/-(3-methy 1-4-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - rx a&gt; XT A 267 4- (6,7,8,9-tetrahydro-5H-pyrido[2,3-d]indol-3-yl)-/V-(3-methyl-4-((1S,4S)- 5- methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)phenyJ)pyrimidin-2-amine 0 1 H -ch3 - Qty H ™ yr B 268 4- (6,7,8,9-tetrahyd ro-5/-/-py rido[2,3-6]indoi-3-yl)-A/-(3-methyl-4-((1S,4S)- 5- (methylsulfonyl)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - H ox zo B 296 297

TABLE 2 (RX (R2)m X5 IC50 activity: A = &lt;1 μΜ ίΡ T \ Pr B = 1to10pM PlP^PPP (la'1) 0 = &gt;10ίο20μΜ Fv Pr Pr D = &gt;20 μΜ I1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 269 4-(4-(trifluoromethyl)phenyJ)-/V-(3-methyl-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - P ^n'CH2 xP A 270 4-(7,8,9,9a-tetrahydro-5H- pyrido[2,3-e]pymoio(1,2- a][1,4]diazepin-10(11 /7)-on-3-yl)-/V- (3-methyl-4-((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2- yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - py Ο H xP A 271 4-(2,2-dimethyl-3-oxo-3,4-dihydro-27/-benzo[b][1,4Joxazin-7-yl)-/V-(3-cyano-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - H3C χσ H JP A 272 4-(2-oxo-2,3,4,5-tetrahydro-1 H-benzo(b]azepin-7-yl)-/V-(3-cyano-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - :o" Ο H JP A 297 298

TABLE 2 (R^n (R2U /R5 IC50 activity: A = &lt;1 μΜ [p T r" Ii B = 1to10pM Jl JL JL Jj {,a"1) C = &gt;10to20pM FT Pr PjT D = &gt;20 μΜ fV Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 273 4-(3-oxo-3,4-dihydro-2H-benzo[2&gt;][1,4]thiazin-7-yl)-A/-(3-cyano-4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -CN - p AN ρρ A 274 4-(3-oxo-3,4-dihydro-2H-benzo[dJ[1,4]thiazin-7-yl)-/V-(3-methyl-4-((18,48)-5-ΓηθηψΙ-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - an A 275 4-(6-(tetrahydropyran-4-yloxy)pyridin-3-yl)-A/-(3-methyl-4-(1,4-diazabicycio[3.2.1 ]octan-4-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - ' ,0' P- A 276 4-(6-(morpholin-4-yJ)pyridin-3-yl)-/V- (3-methyi-4-((/?)-1,4- diazabicycio[3.2.1]octan-4- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - ......O' op P A 298 299

TABLE 2 (R^n (R2)m JX5 IC5O activity: A = &lt;1 μΜ ίΡ Ύ PH B = 1to10pM J! JL JLU &lt;la'1) C = &gt;10to20pM R^V γ V D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 277 4-(6-(morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-((S)-1,4-diazabicyclo[3.2.1 ]octan-4-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 10 cee oP o A 278 4-(2-oxo-2,3,4,5-tetrahydro-1/7-benzo[b]azepin-7-yl)-/V-(3-methyl-4-((6R,9S)-6,9-metha nooctahydro-1/7-pyrido[1,2-ajpyrazin-2-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 03' Ο H .X A 279 4-(3-oxo-3,4-dihydro-2/7- benzo[b][1,4jthiazin-7-yl)-A/-(3- Γηθ^-4-((6/?,95)-6,9- methanooctahydro-1H-pyrido[1,2- a]pyrazin-2-yl)phenyl)pyrimidin-2- amine 0 1 H -ch3 - .0" 0P .X A 280 4-(6-((1 S,4S)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-yl)pyridin-3-yl)-A/-(3-methyl-4-(1,4-diazabicyclo[3.2.2]nonan-4-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 10 P P A 299 300

TABLE 2 fR^n R " IG50 activity: A = &lt;1 μΜ B=1to10pM C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 ICso 281 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/- (3-cyano-4-(3,9- diazabicyclo(3.3.2]decan-10-on-3- yl)phenyl)pyrimidin-2-amine 0 1 H -CN - iY O - 282 4-(2,2-dim ethyl-3-oxo-3,4-di hyd ro- 2B-pyrido[3t2-b][1,4]oxazin-7-yl)-A/- (3-cyano-4-(3,9- diazabicyclo[3.3.2]decan-10-on-3- yl)phenyl)pyrimidin-2-amine 0 1 H -CN - η2Ϊ°ΧΤ crS-^tY H Y5h - 283 4-(6-(tetrahydropyran-4- yloxy)pyridin-3-yl)-/V-(3-methyl-4-(3- (dimethylamino)-8- azabicyclo[3.2.1 ]octan-8-yl)phenyl)pyrimidin-2-amine 0 1 H -CH3 - a 0' QH3 γγ- A 284 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/- (3-methyl-4-(3-(morpholin-4-yl)-8- azabicyclo[3.2.1]octan-8- yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - 0 ac A 300 301

TABLE 2 &lt;R^n 5 R xx IC50 activity: A = &lt;1 μΜ B = 1 to 10 μΜ C = &gt;10to 20 μΜ D = &gt;20 μΜ Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 285 4-(6-(tetrahydropyran-4- yloxy)pyridin-3-yl)-A/-(3-methyl-4-(3- (morpholin-4-yl)-8- azabicyclo[3.2.1 joctan-8-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - A 286 4-(6-&lt;morpholin-4-yl)pyridin-3-yl)-/V-(3-methyl-4-(3-(dimethylamino)-8-azabicyclo[3.2.1 ]octan-8-yl)phenyl)pyrimidin-2-amine 0 1 H -ch3 - &lt;fH3 00“· A 301 302 TABLE 3 (R^)n (R2)m y&lt; P IC50 activity: Α = &lt;1μΜ fp T I II Β=1ίο10μΜ {la‘2) C = &gt;10to20pM R4^ rv PP D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 54 4-(6-(dimethylamino)pyridin-3-yl)-/\/-(6-((1 S,4S)-5-methyl-2,5-diazabicycio[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 0 H - - ΓΫ' ch3 YY Β 55 4-(6-(methylcarbonylarnino)pyridin-3-yl)-A/-(4-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrim!din-2-amine 0 0 H - - ° h3c^n^u 3 H Β 56 4-(4-(dimethylamino)phenyl)-A/-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrirnidin-2-amine 0 0 H - - ch3 YY Β 57 4-(6-(4-acetylpiperazin-1-yl)pyridin-3-y l)-/V-(6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 0 H - - XY o γΧΗ· Β 302 303

TABLE 3 (R^n (R2)m XR5 IC50 activity: A = &lt;1 μΜ IP T rY Β = 1ίο10μΜ 1· JL JL (,a'2) C = &gt;10 to 20 μΜ FT ΤΓ TjT D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 58 4-(5-methyl-6-(morpholin-4- yi)pyridin-3-yl)-A/-(6-((1S,4S)-5- methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 0 H - - P'tbb °L 33'“' B 61 4-(6-(dimethylamino)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin“3-yl)pyrimidin-2-amine 0 1 H -CH3 - iY ch3 33'“' A 62 4-(4-(dimethylamino)phenyl)-A/-(5-methyl-6-((1S,4S)-(5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - ch3 B 63 4-(6-(4-acetylpiperazin-1-yl)pyridin-3-yi)-A/-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - /T 0 33'“' B 303 304

TABLE 3 (Rfyi (R2)m A\ r5 IC50 activity: A = &lt;1 μΜ (P Τ \ II B = 1 to 10 μΜ JyJyJaJ (la'2) C = &gt;10to20pM rA Άγ D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 Rs ICso 64 4-(5-methyl-6-(morpholin-4-yl)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - °A A A 65 4-(4-methyl-3,4-dihydro-2/7-pyrido[3,2-bH1,4]oxazin-7-yl)-A/-(5-methyl-6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yi)pyrimidin-2-amine 0 1 H -ch3 - A N N ch3 A A 66 4-(6-(morpholin-4-yl)pyridin-3-yl)-A/-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yJ)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - A oO " A B 131 4-(4-(/-butylcarbonylamino)phenyl)-A/-(5-methy 1-6-(( 1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - H3C H Ah3 h A A 304 305 TABLE 3 (R^)n (R2)m Vz\ r5 IC50 activity: A = &lt;1 μΜ ίΡ T \ il B = 1to10pM Jil (,a'2) C = &gt;10to20pM FC ΤΓ TjT D = &gt;20 μΜ fV Cpd# Compound Name n m R1 R2 R3 R4 R5 IC5o 138 4-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-A/-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - -rxr Η A 140 4-(4-(3-cyclopropylureido)pheny!)-/V-(5-methyi-6-((1 SASTS-methyl^S-diazabicycic^T. 1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - ΤΑΧΥ Η Η Β 144 4-(6-(2-(morpholin-4-yl)acetamido)pyridin-3-yl)-/V-(5-methyl-6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - Η Β 145 4-(6-aminopyridin-3-yl)-A/-(5-rnethyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - η2Α^ A 146 4-(6-(acetamido)pyridin-3-yl)-A/-(5-methyl-6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine | 0 1 H -ch3 - ηΛ^ Η Β 305 306

TABLE 3 (R^n (R2)m p5 icso aciivity; A = MM ίΡ Ύ I N B=1to10pM J· JL JL k (,a'2) C = &gt;10to20pM P PP PP D = &gt;20 μΜ FV Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 154 4-(6-(methylsulfonylamino)pyridin-3-yl)-/V-(5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 jheptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - 0 H3C-,1NA&gt; ο H P"' D 177 4-(2-(dimethylamino)thiazol-4-yl)-A/-(6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amtne 0 0 H - - h3c m TT P“· D 180 4-(5-(morpholin-4-yl)pyrazin-2-yl)-A/-(6-((1 S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]hepian-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 0 H - - IT O " B 236 4-(1 -(pyridi n-4-y 1)-1 H-indol-5-yl)-A/~ (5-methyl-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - TQV ό A 306 307

TABLE 3 (R^)n (R2)m NR5 IC50 activity: A = &lt;1 μΜ ίΡ T \ ii Β = 1Ιο10μΜ J* P. Jij (la’2) C = &gt;10to20pM R' PP PP D = &gt;20 μΜ R1 Cpd# Compound Name n m R1 R2 R3 R4 R5 IC50 266 4-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yi)pyridin-3-yl)-/V-(5-methy!-6-((1 S,4S)-5-methyl-2,5- diazabicyclo[2.2.1 ]heptan-2-yl)pyridin-3-yl)pyrimidin-2-amine 0 1 H -ch3 - rx 00 " A 307 308

All ofthe U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specification and/or listed in the Application Data Sheet are 5 incorporated herein by reference, in their entireties.

Although the foregoing invention has been described in some detail to facilitate understanding, it will be apparent that certain changes and modifications may be practiced within the scope ofthe appended claims. Accordingly, the described embodiments are to be considered as illustrative and not restrictive, and the invention is 10 not to be limited to the details given herein, but may be modified within the scope and equivalents of the appended claims. 308