Powder inhalation device.

Pantanassis 5, 151 25 - Paradise of Maroussi ^ -536 ^

F. 1785

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Devices for inhalation of powdered medicines

Techn_iko_ped io ___ ^ I_efef £ est2_afti_anafereta j se_d provision In j s_o t which diefkolynoun_tin eispnoi_apo_to_stoma_farmakon OE form okonis n_iki_ypo £ dG rou_ 'There are many commanding facilitating inhalation (aspiration), orally in form of powder drug to the chrisomopoiisi propulsion means, just as the compressed gas , for administration and jX \

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- 2 dispersion of the drug. These devices are usually complex in manufacture and have the disadvantage that, in order to achieve the best results, inhalation should be given at the same time.

There are also many inhalation-activated inhalers for the administration of powdered medicines to the lungs, which have epitopes through which the drug is inhaled. Powdered medicine is usually provided in commercial capsules. comprising a first and a d, a second portion, each comprising a tubular portion with an open end and an end wall opposite the open end, wherein the open end and the tubular portion of one part passes through the end Both tubular parts are held together by friction, immediately containing the drug in powder. In the simpler devices which are actuated by breathing or capsule, it is opened prior to insertion into the device and a portion of the capsule containing the drug, or the same drug, is inserted into the device so that, during breathing, , the drug should be drawn into the air stream and passed to the patient.

Examples of such systems are described in British Patents 1,520,014, 1,504,441, IIIII.34I, 522.063 and 1.520.062

These devices have the disadvantage of being spilled when the capsule is opened before insertion.

medicine can help them

English Patents I.52 I.C.CO., 1.477.650 and 1.502.150 describe more complicated or complete capsules inserted into the device that will not spill the drug before inhalation and

1520.062, provisions thereby ensuring access to the farm

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- 5 is achieved by piercing the capsule or cutting it through the drug delivery device. Upon inhalation the air flows through the capsule and the dust contained therein drifts through the gas and flows through the mouth.

In the provisions described in English Patents 1,485.163, I.331.216, 1.457.352, 1.396.258, 1.182,779, --- 1.404.338, 1.459.426, and I.II8.34I and the patents respectively.

USA. 4.II7.844 and 4.116.195 are indicated to be disrupted or a capsule containing the medicament to facilitate the release and / or dispensing of the drug from the capsule. * The capsule can be agitated in a number of ways, such as creating a turbulent flow of air or rotating or vibrating the capsule using faucets or propellers --- propellers.

These devices are complicated and often difficult to use.

U.S. Patent 4,210,140 describes a device in which access to the drug in the form of a powder is achieved by pulling the two portions so that the drug can be separated and emptied into an appropriate position from which it will be dragged. caused by inhalation.

Our 'pending publication' PCT Publication No. 81/01243 describes inhalation-activated devices for oral aspiration of powdered medicines. These devices include a chamber having at least one inlet for air intake and in direct communication with a mouthpiece, in-chamber systems for. the capsule containing the medicament substantially perpendicular and the systems for separating the capsule portions into a chamber so as to expose the open end of the lower portion of the capsule so as to allow access to it. an aspiration in the abutment of the device, the air passing through the open end of the lower portion of the capsule, thereby obliging the particles of the drug powder to be drawn up by the gas stream.

The devices described in this application are easy and simple to use, reduce the likelihood of dispersal of the drug by the user, and ensure that even the spilled drug can be administered and is very effective when compared © the breathing of the prior art. However, the placement of the systems for separating the capsule components into the chamber presents the air inflow capability within the chamber and limits the possibilities for designing to provide a desired air flow pattern through the chamber.

Description of the Invention The present invention provides a device for breathing-activating or facilitating the inhalation of powdered medicines contained in a capsule, or any device comprising a device which facilitates the user to disassemble the capsule portions and allow the device to have an excellent air flow diagram through the chamber in which the detachable capsule portions are located so as to .

According to the present invention there is provided a device for facilitating the inhalation of the powdered medicaments into a capsule comprising a first portion suitable for containing the powder with an open end and a second portion closing the open end of the first part of the capsule. * The device comprises a main body with walls defining a chamber, at least one chamber inlet for air inlet, and a mouthpiece provided with a central aperture that crosses and communicates with the chamber.

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A hand-actuated midsole mounted on the body is provided for the transfer of the first portion of the capsule from a first position, some distance from the chamber, to a predetermined delivery site within the chamber, with the open end of the first part of the capsule upwards, so that the air flows through the inlet and through the chamber, caused by the aspiration of the clasp; It obligates the powdered medicine into the first portion of the capsule to be drawn by the stream of air. A hand-actuated means mounted on the body is also provided to remove the second portion of the capsule from the first portion of the capsule before moving the first portion of the capsule to the delivery position.

The devices of this invention can be adapted to accommodate. Conventional capsules of the type used in the pharmaceutical industry, which, as described above, consist of two parts, each comprising a tubular portion with an open end and an end wall on either side, where the open end and tubular part of one part enters the open end of the other part and the two parts are held together by friction, Immediately constituting the drug in the form of a powder, Alternatively the devices of our invention may be adapted for use with capsules or shells of other shapes, wherein access to the first portion of the powder capsule is achieved immediately afterwards. capsule from the opening of the first portion of the capsule (e.g. by displacing a back portion in the form of a stopper or a laminated or folded sheet cover from the open end of a first portion of a capsule in any suitable shape). a capsule which may have the first portion of it molded in its entirety into a movable portion, providing means for transportation, whereby a wall

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- 6 soil of the body of the device supplies the second portion of the capsule. All the second portion of the capsule is provided by a laminate on the open end of the first portion of the capsule.

The means of conveyance in a device according to this invention may comprise a cylindrical container rotatably mounted on the body of the device which is designed to transfer the first portions of the capsule one after another. first position at the site of administration. When such a device is adapted to be used with the classical capsules of the type described above, the receptacle may have a plurality of radially extending sockets having openings on its periphery, such that each receptacle may be adapted. and hold the first portion of the capsule frictionally so that the first portion of the capsule is removed from the socket, to have a force exceeding that required for the separation of the capsule parts. The means for removing the second portion of the capsule may include a jaw-type extractor, suitable for frictionally securing the second portion of the capsule, whichever extruder is mounted between the attachments. , in which the jaw walls are located far from the capsule in the container in the first position, and a synchronization site, in which the walls - jaws; a second portion of a capsule in the support in the first position.

In addition, the device may comprise coupling means, between the transducer and the extruder, to move the receptacle so as to transfer an open first portion of the capsule from the first position to the delivery site, while moving the extruder from the transmitter position. remote location. These coupling means may be a coupling system comprising one

- 7 wheel, with teeth on its circumference, fitted axially to the subframe and a ratchet coupled to the extruder and properly arranged to grip and propel the wheel when moving the extruder from the retainer position.

The extruder may be a separate member mounted movably on the body or it may be incorporated on a cover, rotatably mounted on the body, a portion of which is located on the aperture opening where the protuberance is located. its place.

The inlet openings and the chamber can be arranged in such a way as to provide a flow of air that is uniformly directed transversely to the open end of the first position and not the first portion of the capsule. This or air flow has the effect of draining the powder out of the capsule, apparently due to a resonance effect caused inside the capsule in a manner similar to the resonance caused when we blow over the nozzle.

The tests performed show that for air flows transverse to the open end of the first portion of the capsule, there is an excellent position for the open end of the first portion of the capsule relative to the lower sides of the inlets.

This position may vary unnecessarily with the dimensions of the capsule portion and the amount of drug in the capsule portion. It does not tend to become critical for capsule portions relatively shallow (eg up to 10 mm) but becomes more critical when using deeper capsule portions. * It has generally been found that the open end of the capsule should not extend far above the lower side of the inlet opening which is preferably in the same plane or slightly lower than the lower side of the inlet opening, so that the drug in the portion capsule yes

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- 8 is slightly lower than the main stream of gas flow. PCT Publication no. 81 / 0.1243, appended hereto, describe / describe in more detail the relative positions of the air inlets of the capsule portion and the fasteners together with experimental results. *

The device according to the present invention may also be designed such that a portion of the gas stream through the chamber enters the first portion of the capsule to expel the drug powder therefrom. In. a preferred embodiment, comprising said feature, or upper surface of the chamber, has a downward inclination, upstream of the dispensing position for the first portion of the capsule, and inclined upward downstream of the dispensing site with the inclination of the inclinations upper surfaces aligned with the longitudinal axis of the first portion of the capsule in the dispensing position and a short distance from the open end of the first portion of the capsule.

The chamber must be designed so that the velocity of air within the open end of the capsule portion is large. However, the pressure drop along the chamber used should not be high, as this would require the user to perform a significant suction while in a depleted state. With the present invention we can achieve the desired velocity of gas flow along the portion of the capsule and at the same time prevent a pressure drop; along the chamber only 5 cm. about a water column, which is barely noticeable to the user.

A drop of up to 50 cm. water seems to be the upper limit for user comfort.

The mouthpiece is preferably short: both straight and gas-aligned, passing through the open end of the capsule portion, so as to be substantially straight or flowing through the device. However, the mouthpiece may have a shape or a slight inclination relative to the gas stream along the portion of the capsule, without appreciably affecting the efficiency of the device, provided that there are no gaps to trap the particles inside the capsule. . It may be advantageous to increase the surface area of ​​the mouthpiece cross-section, so allow all large or immobilized particles in the drug powder powder to settle into the cuff; rather than end up in the mouth . The mouthpiece of the device can be adapted for inhalation of the nose, and the mouthpiece used herein includes such nose adaptations.

in similar sections to the drawing of a first embodiment, which has a section on the design_of_the invention will further describe with reference to the accompanying drawings, which like numbers refer to different designs and to which?

Fig. I is an open perspective view of a device according to the present invention, so as to illustrate the details.

Fig. 2 is a perspective view of the back side of a receptacle for capsules adjacent the front view in Fig. 1;

Figures 3a to 3it are various sections of the arrangement Fig.

I, which denote the / &lt;&lt;of the function.

Fig. 4 is a section of a second embodiment of the device according to this invention.

Fig. 5 is a cross-sectional view of a third embodiment of the device according to the invention.

- IO

FIG. Is a fractional cross-sectional view along approximately line 6-6 of FIG. 5;

Fig. 7 is an open view of a fourth embodiment of a device according to the present invention and "

Fig. 8 is a sectional view of the arrangement of Fig. 7

Detailed description; Referring now to Figs. 1,2 and 3a to 3 / we have an embodiment of the first embodiment of a device according to the present invention, indicated by reference reference ID 10.

The device IC has been adapted to facilitate oral inhalation of powdered medicines into a capsule II of the type commercially available, or comprising a first and a second portion 12 and 14 of a capsule, each of which 12 and 14 comprises a cylindrical tubular portion with an open end and a hemispherical end wall opposite the open end where the open end and tubular portion of one capsule portion enters the open end of the other tube portions are held together by friction so as not to contain the drug powder directly.

Generally the device comprises a body Lb with walls which partially define a barrier 16 free of obstructions at least one gas inlet opening 17 into chamber 16 and a valve 18 having a central through passage 19 which communicates directly with chamber 16. Manual means, in the form of a cylindrical generally capsule receptacle 20, are mounted on the body 15, so as to rotate around a mirror 22, to transfer the first portion of the capsule 12 from a first position (C). , located some distance from chamber 16, at a predetermined delivery location (Fig. 3i () within chamber 16 (which chamber 16 is partially defined by the periphery of the receptor 20).

At the delivery site δ receptor 20 constitutes^- the open end of the press-Wheat portion of the capsule 12 upwards so that the gas stream through the inlet 17 and through the chamber 16, which is discharged through the mouthpiece 18, flows transversely to the open end will force the powder of the drug into the first portion of capsule 12 to drain the gas stream. They are manually viewed in the form of an extruder 23, mounted so as to slide over the body 15, to remove the second portion of the capsule 14 prior to transferring the first portion of the capsule 12 to the dispensing position 3. 3f).

The body 15, which is injection molded preferably from a suitable polymer material, comprises a central portion 24 with walls comprising a cylindrical side wall from which the pillar 22 protrudes, the walls defining an inferior cylindrical cavity in which the capsule container 20 and the extruder 23 are assembled, and a side portion 25 connected to the main portion 24 by means of a flexible hinge 26, which comprises a circular side wall from which a cylindrical tube centrally protrudes 27. * The inner surface of the tube 27 is properly shaped so that it is frictionally formed around the pole 22, so as to hold the container 20 of the capsules and the extruder 23 into the cavity, and to integrate the center portion 24 and 25 of the body. Also included in the body 15 is a cover 28, connected at one end through a thin portion on the body 15, so that it can rotate between an open position away from the end of the mouthpiece 18 and from the opening 25, above the end wall of body 15, through which it passes and driven by an end portion 30 of the extruder 23 (FIG.,

J? , 3C and / or, and an enclosed position (Fig. 3a) with a portion of the cover 28 extending through the opening 29 and a peripheral portion 31 of the cover 23 extending through the opening of the closure 29, in any closed position cover 28 is retained due to locking of the upper end of the bolt 18 in a groove of the hook portion 31.

The capsule holder 20 comprises a circular wall 32 with a central aperture through which a pole 22 enters, a central peripheral wall 33 with ordered openings passing through the first portions of the capsule 12, and extending radially ( of the capsule 34 extending perpendicular to the side wall 33, which holds by friction the opposite sides of the first portions of the capsule 12 with a force exceeding that required to separate the portions 12 and 14 of the capsule. The rotation of the receptacle 20 obliges capsules II to be moved in turn from an arcuate storage 35, defined by body parts 15 and the receptacle 20, in the first position as well as the precursor capsule II is opened and the first portion 12 is moved of administration. An extension 37 is present in the receptacle 20. * This extension 37 will move to the first position as the first portion 12 of the last unused capsule II is moved to the dispensing position in the device and contributes to the operation of the extractor 23 and closure 28, to indicate to the user that all ol capsules II which were in arrangement 10 have been used (Fig. 3 ^). On the side wall 33, a gear 36 is formed coaxially against the retaining walls of the capsule 35 (Fig. 2). This gear 36 is a part of the coupling system providing the coupling means between the housing 20 and the extruder 23 for moving the housing 20 so as to move the first portion 12 of the capsule from the first position to the delivery position as ejector 23 is moved to remove the second portion of capsule II as explained below.

extruder 23 comprises the end portion 30, which is defined 15 by the walls defining the opening 29 in the body I5&gt; of any end portion 50 projecting retaining walls 58 suitable for holding frictional sides of the second 14 of the capsule II.

A section 59 in general shape ZZ of the extruder 25 projects from the end portion 50 and what is it? opposite its surface properly; configured to slide along and guide the opposing surfaces of the cogwheel 56. This guidance of the extruder 25 enables it to slide radially as far as the outlet 20 between a stand. 5a) with retaining walls 58 removable from a capsule II located in the container 20 in the first position, and of a retention site (Figs. 5a and 5b) with retaining walls 58 engaging with the second portion 14 of a capsule II in first class. Two wavy flexible, elastic spring sections 40 of the extruder 25 also project from the end portion 50 along the opposite sides of the portion 59 in shape and provide spring means between the body 15 and the extruder 25 for holding it 25 . An extension to the inner chest 51. is located at the peripheral end of a portion of section 59 in the shape of KL and is configured to act as a gear 56 to act as a "prosthesis for the mounting system and to propel the wheel 20". so that the first part II of a capsule proceeds from the first position to the dispensing position as the ejector 25 moves from the retention position to its remote position below the effect of the spring sections 40.

Binding means are provided for engaging the ejector 25 in the retention position. The body 15 comprises a plate portion 42 in the shape of a plate having one end attached to the wall defining the side of the opening 29 adjacent to the IS mouthpiece and the opposite side associated with the mouthpiece 18 and the center portion of the portion 42 bending normally upwardly removed from the wall defining the upper surface of the chamber 16. The engagement portion 42 comprises a rim 43 which, when the engagement portion 42 is bent upwards, projects into the opening 29 where it may be engaged with a projection 44 bits long of the end portion 30 of the extruder 23 (Fig. 3b) and so on. Assemble the extractor 23 in the holding position. The engagement portion 42 can be manually pressed against the wall defining the upper surface of the chamber 16 (FIG. 3C) force the rim 43 to divert away from the projection 44 and return to the extruder 23 to move to its remote position.

We will now explain the operation of device 10 by assuming that the puller 23 is first positioned in its locking position with the aid of fastening means, with the jaw walls 37 of the puller 23 being locked in the second position 14 of the first section 14 , and the cover 28 in its closed position (Fig. 3a&gt;. The user first releases the clamping means by bending the hook 31 of the cover 28 to the outside of the clasp 18 and rotating the cover 28 so as to open (Fig. 3b). It then pushes the locking portion 42 toward the wall defining the upper surface of the chamber 16, which is removable / lip 43 from the projection 44, so as to slide the extruder from its locking position to the lower one springs 40. During the first stage of this movement, portions 14 and 12 of the capsule are separated due to their frictional retention by the extractor 23 and the container. 20 Correspondingly (Fig. 3c) · During the second stage of this movement or the rubber 44 of the extractor 23 obliges the gear 36 to advance the first portion 12 of the capsule from the first position to the site of administration. The user can then inhale through the valve 13, forcing the air to enter chamber 16 through the inlet opening 17, crossing the open end of the valve.

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- 15 of the first portion 12 of the capsule at the site of administration, to draw the pharmaceutical powder into the gas stream and drive it to the user's lungs. The user can then return the cover 28 to the closed position, whereby the engagement 28 with the protruding end portion 30, the puller 23 moves the puller 23 to the locking position, so that the second portion 14 is displaced from it. retaining walls 37 from the second portion 14 of the new closed capsule II in the first position (Fig. 3 £), after which the retaining walls 37 catch the second portion 14 of the new capsule. There are enough three-thirds of the body 15 and the receptacle 20 of the capsule, so, as the puller 23 is now moved to its locking position, the portion of the portion 39, which holds the ratchet 41, diverges outward. due to engagement between the ratchet 41 and the convex outer surface of the next tooth of the gear 36, so that the ratchet travels around the tooth of the tooth wheel 36 rather than rotating the retainer 20 of the capsule backwards. When the extruder 23 reaches its locking position, the lip 43 is engaged with the protrusion 44 so as to again engage the extruder 23 in its position. The gripped end portion 31 of the cover 28 is again engaged with the end of the bolt 18 so as to keep it closed and the device 10 is ready for re-use.

In Fig. 4 we have now illustrated a second embodiment of the device according to this invention, generally referred to by reference number 50.

As well as device 10, device 50 is suitably configured to facilitate inhalation of pharmaceutical powder into capsules II of the type commercially described and described above, consisting of a first and a second capsule 12 and 14 , and this arrangement comprises a body 51 with walls defining partially an obstruction-free chamber 52, at least one opening aperture 53 to chamber 52 and a mouthpiece 54 provided with a central through passage 55 which communicated directly with chamber 52. Also as IO device _n manually in the form of a generally cylindrical container 56 of the capsules, is rotatably mounted: on the body 51, to transfer the first portion 12 of the capsule from a first position, distal to the chamber 52, in a predetermined position 52 (each chamber 52 being partially defined by the circumference of the cuff 5b) and in the delivery position the receptacle holds the open end of the first portion 12 of the capsule,)

upwards, so that the gas passes through the inlet 53 and through the chamber 52, 6 which is caused by the suction in the cuff 54, will cross the open end and force the medicinal powder in the first place section 12 of the capsule to be withdrawn from the gas stream.

Manual means are also provided for removing the second portion 14 of the capsule prior to moving the first portion 12 of the capsule to the dispensing position, but unlike device IC, these means consist of a wall or extruder 57, defines an opening and is suitably configured to hold frictionally the second portion 14 of capsule II, any extruder 57 being incorporated into the cover 58 of the device 80.

The body 51 has walls defining a generally cylindrical cavity in which the receptacle 56 of the capsules is rotatably assembled. The cover 58 is molded together with the body 51 and is rotatably connected at one end through a fine portion of the body 51 so that it can * rotate between an open position, which is distal from the distal end 54 in which the extruder 57 is in a distant position from an opening 59

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- 17 of the end wall of the body adjacent to the first position, and of a closed position in which the extruder 57 is positioned in the engaging position in the opening 59 and holding the second portion 14 of the capsule II in the first position and a hook peripheral portion 60 of the cover 58 extending through the opening of the mouthpiece 55 and is formed in this position due to a lip engaging 61 of the peripheral portion 60 with the lower edge of the mouthpiece 54.

The capsule holder 56 comprises a cylindrical peripheral wall 62 with arranged apertures within which the first portions of 12 of capsules II are mounted and frictionally assembled in radially extending sockets with a force or direction that is superimposed of the 12 and 14 portions of the capsule. The rotation of the container forces capsules II to move, or one after another, from an arcuate storage 6b, defined by body parts 51 and the container 56, in the first position, and the former capsule II being opened first part of the carrier at the place of administration. A gear 64 is coaxially formed on one side of the receptacle 56 and together with a ratchet 65 which is mounted on the cover 53 and protrudes from ./ y. These forming a tfuF'typJ * constitute 7 (7 coupling means that engage between the receptacle 56 and the extruder 57, to move the receptacle 56 'so as to transfer the first portion 12 of the capsule from the first position to the delivery site The ejector moves from the lock position to the open position (where it is in which the cover 53 is open).

We will now illustrate the operation of the device 50 assuming that the cover 58 is initially closed, so that the extruder 57 on the cover 58 is in a retention position with the first portion or portion 12 of a capsule II in the first position. '0 user first take cover 5S by bending the hook 60 of the cover 53

IS removes it from the bracket 54 and rotates the cover 58 in its open position, whereby the extruder 57 on the cover 58 is moved from its locking position to its remote position.

In the first stage of this movement, sections 12 and 14 of capsule II are removed in the first place because of their locking due to three

With the extruders 57 and the receptacle 56 respectively and in the second step of this movement or ratchets 65 on the cover 58 it is mandatory for a gear tooth 64 to advance the open first portion 12 of the capsule from the first position of the donor.

The user can then inhale through the mouthpiece 54, which forces the air to penetrate into the chamber 52 through the inlet opening 55, and crosses the open end of the first portion of the capsule 12 in the delivery position, so as to deliver it. pharmaceutical powder into the gas stream and transfer it to the user's minds. The user can then remove the separated second portion of the capsule 14 from the extruder 57 and close the cover 58 so that the extruder 57 can capture the second portion 14 of the new capsule II in the first position. There is enough friction between the body 51 and the capsule receptacle 56 so, as the closure closes 58, or the ratchets 65 and the new tooth of the gear 64 overtake each other because of their angular relationship to their surfaces. Touch, without causing it. rotation to the back of the 56 capsule receptacle. When the.. When the extruder has reached its locking position, the lip 61 compels the mouthpiece 54 to hold the cover closed and the device 50 is ready to be reused.

When the device 50 has been used several times so that the first portion of the last unused capsule II on the receptacle 56 is transported to the delivery site, there will be a disproportionately large IWi of space 63 between the successive teeth on the gear 64 adjacent to the 55 of cover 58 ./.

- 19 '0 space 68 is large enough so that subsequent closure of cover 58 or ratchet 65 will not come into contact with the next tooth of the gear 64 but will overtake it. * The freedom of movement of the cover thus obtained will tell the user that the 5® device is empty.

In Figs. 5 and 6 we illustrate a third embodiment of a device according to the present invention generally indicated by reference number 70.

ⁿLike the devices 10 and 50, the device 7i is suitably configured to facilitate inhalation of pharmaceutical powder into capsules II of the type commercially available and described above, comprising a first and a second capsule portion 12 and 14.

This arrangement comprises a body 71 having walls partially defining a chamber 72. at least one air inlet opening 73 into chamber 72 and a mouthpiece 74 having a through passage 75 communicating directly with chamber 72. Also as in device 10 and 50, manually in the form of a generally cylindrical container 76 of the capsules, are rotatably mounted on the body 71 to convey the first portion 12 of the capsule II. from a first position distant from chamber 72 to a predetermined delivery position within chamber 72 (which chamber 72 is partially defined by the periphery of the receptor 76), and in the delivery site to the receptacle 76 brings the open end of the first portion 12 of capsule upwards, so give the gas stream that passes through the inlet opening 73 and crosses the chamber 72, due to the suction on the clamp 74, It will oblige the pharmaceutical powder in the first section 12 to be drawn into the gas stream. 'As in the device 50 manual means, in the form of a wall or extruder 77 having a surface or which defines an aperture and is adapted to be properly secured /', -

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due to friction the second portion 12 is embedded in the cover 78 for device 70 and removing the second portion of the capsule 14 before transferring the first portion 12 of the capsule to the delivery position.

The body 71 has walls defining a generally cylinder

the cavity within which the receptacle 76 is rotatably mounted. The cover 78 is molded together with the body 72 and connected therewith to rotate an open position remotely from the end of the pivot 74, in which the retractor 77 is located far from an opening 79 in an end wall. body next to the first position, and a closed position in which the extruder 77 is in the retention position in the opening 79 and frictionally holding the second portion 14 of a capsule II in the first position and an angular peripheral portion 80 of the cover 78 extending through the aperture 75 in this position due to a locking of the upper edge of the clasp 74 in a notch of the clamp portion 80 of the cover.

The enclosure 76 of the capsules comprises a cylindrical peripheral wall with ordered wires within which the first portions of 12 of capsules II are located and frictionally formed in radially extending enclosures with a force exceeding that required 12 and 14 of the capsule II. rotation of the container 76 obliges capsules II to be moved one after another from an arched storage 81, defined by the body 71 and the support 76, in the first position, as well as the former capsule being opened and the first portion 12 opened x direction. A gear wheel 84 is axially shaped, one side of the receptacle 76 and with a ratchet 85, protruding from the cover 78 and mounted therein, forms a system containing the coupling means between the sub-21 receptacle 76 and a stroller 77 located on the cover 78, thus allow container 76 to move the first portion 12 of the capsule from the first position to the delivery position during movement of the extruder 77 located on the cover 78 from the engagement position to the open position (corresponding to the opening). of cover 78).

The device 70 is handled by the user in the same substantive manner as described above with reference to the device 70 and differs substantially from that in the shape of an inner surface of the upper wall defined by the chamber 72. In device 70 this portion 87 of the interior surface from the air inlet opening 73 to the dispensing position is inclined downward, while a portion 88 of the interior surface from the dispensing chamber 54 has clasps | upwards. "A longitudinal axis 89 of the first portion of capsule II in the dispensing position is aligned with the intersection of the inclined surface portions 37 and 88, and this section is located a short distance from the open end of the first dispensing portion 12 in the dispenser.

This arrangement apparently forces a part of the air inhaled through chamber 72 to pass through the first portion 12 of the capsule and expel the pharmaceutical powder from it.

As a non-limiting example, we report that good results are obtained; either the angle between the surface portion 87 and the shaft 39 is 45 °, or the angle between the surface portion 88 and the shaft 89 is approximately 55 ° or the cross-section of the surface portions 87 and 38 is about 1 mm above the open end of the first portion 12 of the capsule.

6 and 7 have illustrated a fourth embodiment of a device according to the invention, generally referring to the reference number 90.

"Like the ICs 50, 50 and 70, so forth," fO-el or "HT" is suitably designed to facilitate the inhalation of powders of medicines in capsules consisting of fibers in the morning, and in section two 92 and 95. This arrangement comprises a body 94 having walls defining a barrier 95 without obstructions, at least one inlet 96 for air entry into said chamber 95 and a bar 97 having a central passage 98 directly chamber 95. This arrangement, as well as provisions 10,15 and 70, comprises manual actuators with ^tor the form of a generally cylindrical capsule holder 99 rotary assemblies for use on this body 94 to transfer the first portion (92) of the capsule from a first remote location; from chamber 95 to a predetermined delivery position within this chamber 95 (whichever chamber is partially defined by the circumference of the trunk 99) and in the delivery position the trunk 99 holds the open end of the first portion of the capsule 92 , so that the gas eS current passing through the inlet opening 96 and passing through the chamber 95, the aspiration through the valve 97 will pass transversely to the open end of the first portion of the capsule 92 and will force the pharmaceutical powder contained therein to be withdrawn from the gas.

Devices 10, 50 and 70 also provide manual means for removing the second portion 95 of the capsule before moving the said portion 92 of the capsule to the dispensing position,

In contrast to the arrangement 10.50 and 70, the container 90 has a portion &lt;0 of the capsule 92 formed around its periphery and the second portion 95 of the capsule has a wall on the body 71 covering the first portion 92 in the first place. * Manually rotating the container 98 with the help of a manual button at its end forces the second portion of the capsule or wall 99 to be removed from the first portion of the capsule before moving the first portion of the capsule to the delivery position.

The devices IO, 50 70 or 90 may be made of a suitable polymeric material such as polypropylene or nylon and at least portions of the device may be sufficiently transparent so that the user can easily determine when a first capsule portion is in place. administration site and how many unused capsules remain in the device.

Having thus described the present invention with reference to its embodiments, we believe it will be apparent to those skilled in the art the art of being able to effect many modifications to the arrangement without departing from the spirit of the invention. Thus, the general scope of this invention should not be limited by the embodiments of the embodiments described herein other than the embodiments described in the appended claims and their equivalents.