Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them

A procedure for the preparation of a cis compound of the general formula: **(See formula)** where R'1 is hydrogen, C1-C8 alkyl or **(See formula)** R4 and R5 are independently hydrogen, C1-C3 alkyl, or halogen; n is 0, 1, 2, or 3; m is 0 or 1, with the exception that when m is 0, n is other than 0; X is CO, CHOH, CH = CH, S u 0, except that when n is 0, X is different from S or O; and R2 is hydrogen, hydroxy or C1-C3 alkoxy; and its non-toxic and pharmaceutically acceptable acid addition salts; whose procedure is characterized by reacting a compound of the general formula: **(See formula)** where R'1 and R2 are as defined above, with a reducing agent, optionally cleaving the compounds of formula (II) where R'1 is C1-C8 alkyl or **(See formula)** to obtain the compounds of formula (II) where R'1 is hydrogen and optionally deesterify the compounds of formula (II) where R2 is C1-C3 alkoxy to obtain the compounds of formula (II) where R2 is hydroxy. (Machine-translation by Google Translate, not legally binding)