Activity-based probe compounds, compositions, and methods of use

Activity-based probe compounds are provided for use in labeling a cysteine ​​protease. The compounds target the protease through a specific targeting element. The compounds further include a detectable element, such as a fluorescent label, a radiolabel or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example to label a protease in an animal and visualize a tumor in an animal. (Automatic translation with Google Translate, without legal value)