Combination formulation of two antiviral compounds
Abstract
A pharmaceutical composition in the form of a fixed dose combination tablet comprising: a) from 1% to 25% w/w of a solid dispersion comprising Compound I dispersed within a polymeric matrix formed by copovidone, where the ratio in weight of Compound I to copovidone in the solid dispersion is 1:1 and wherein Compound I is substantially amorphous having the formula: **(See formula)** b) 35% to 45% w/w of sofosbuvir characterized by 2θ reflections of XRPD (º ± 0.2θ) at: 6.1 and 12.7 or at: 6.1, 20 .1 and 20.8, where sofosbuvir is substantially crystalline having the formula: **(See formula)** c) from 1% to 40% w/w of microcrystalline cellulose; d) from 1% to 8% w/w croscarmellose sodium; and e) from 0.5% to 2.5% w/w of magnesium stearate; for use in the treatment of hepatitis C.
Term
7.4 yearsto projected expiry
Projected expiry 30 January 2034, counted from filing; an application has no term until it is granted.
- Priority and filed
- Published
- Today
- Projected expiry
54 members in 21 offices
Members54
| Document | Office | Kind | |
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| CA2921160A1 | Canada | A1 | |
| US2015064253A1 | United States of America | A1 | |
| WO2015030853A1 | World Intellectual Property Organization (WIPO) | A1 | |
| UY35300A | Uruguay | A | |
| TW201511756A | Taiwan Province of China | A | |
| AR095133A1 | Argentina | A1 | |
| AU2014311827A1 | Australia | A1 | |
| SG11201600919UA | Singapore | A | |
| CN105517540A | China | A | |
| IL243988A0 | Israel | A0 | |
| IL243988D0 | Israel | D0 | |
| KR20160047522A | Republic of Korea | A | |
| MX2016002185A | Mexico | A | |
| EP3038601A1 | European Patent Office (EPO) | A1 | |
| JP2016529293A | Japan | A | |
| EA201690473A1 | Eurasian Patent Organization (EAPO) | A1 | |
| US2017095499A1 | United States of America | A1 | |
| HK1220392A | Hong Kong, China | A | |
| HK1220392A1 | Hong Kong, China | A1 | |
| NZ716840A | New Zealand | A | |
| US9757406B2 | United States of America | B2 | |
| AU2014311827B2 | Australia | B2 | |
| HK1225626A | Hong Kong, China | A | |
| HK1225626A1 | Hong Kong, China | A1 | |
| JP2017222718A | Japan | A | |
| AU2017276223A1 | Australia | A1 | |
| US2018021362A1 | United States of America | A1 | |
| TWI626048B | Taiwan Province of China | B | |
| JP6360607B2 | Japan | B2 | |
| US10086011B2 | United States of America | B2 | |
| US2019240246A1 | United States of America | A1 | |
| CN105517540B | China | B | |
| AU2017276223B2 | Australia | B2 | |
| AU2019264624A1 | Australia | A1 | |
| EP3038601B1 | European Patent Office (EPO) | B1 | |
| EP3650014A1 | European Patent Office (EPO) | A1 | |
| PT3038601T | Portugal | T | |
| SI3038601T1 | Slovenia | T1 | |
| PL3038601T3 | Poland | T3 | |
| ES2792503T3 | Spain | T3 | |
| US2021000854A1 | United States of America | A1 | |
| KR102239196B1 | Republic of Korea | B1 | |
| CA2921160C | Canada | C | |
| US11116783B2 | United States of America | B2 | |
| EP3650014B1 | European Patent Office (EPO) | B1 | |
| AU2019264624B2 | Australia | B2 | |
| PT3650014T | Portugal | T | |
| PL3650014T3 | Poland | T3 | |
| SI3650014T1 | Slovenia | T1 | |
| US2022072021A1 | United States of America | A1 | |
| ES2900570T3This record | Spain | T3 | |
| EP4005560A1 | European Patent Office (EPO) | A1 | |
| US11707479B2 | United States of America | B2 | |
| EP4005560B1 | European Patent Office (EPO) | B1 |
Numbers
- Publication
- 2900570
- Application
- 19211345
Titles2
- Spanish
- Formulación de combinación de dos compuestos antivirales
- English
- Combination formulation of two antiviral compounds
Classification
- CPC, 12
- A61K31/4188
- A61K31/7072
- A61K9/1623
- A61K9/1635
- A61K9/2054
- A61P1/16
- A61P31/12
- A61P31/14
- A61P43/00
- A61K9/284
- A61K31/7056
- A61K2300/00
- IPC, 9
- A61K9 16
- A61K9 20
- A61K31 4188
- A61K31 513
- A61K31 7072
- A61P1 16
- A61P31 14
- A61P43 00
- A61P31 12