Inhibitors of sodium glucose cotransporter 1

Compound of formula: ** (See formula) ** ** (See formula) ** or a pharmaceutically acceptable salt thereof, in which: R1 is hydrogen or optionally substituted C1-10 alkyl, C1-5 cycloalkyl, or 5-membered heterocycle, wherein the optional substitution is with one or more R1A, each R1A is independently amino, ester, amide, thiol, acid carboxylic, cyano, halo, hydroxyl, or optionally substituted C1-4 alkoxy, C1-5 cycloalkyl or 5-membered heterocycle, wherein the optional substitution is with one or more R1B, each R1B is independently C1-4 alkyl, halo or hydroxyl, n is 0, 1 or 2, each R2A is independently hydrogen, C1-4 alkyl or acyl, R3 is independently halo, hydroxyl, or optionally substituted C1-10 alkyl, or C1-10 alkoxy, wherein the optional substitution is with one or more R3A , each R3A is, independently, amino, ester, amide, thiol, carboxylic acid, cyano, halo, hydroxyl, or optionally substituted C1-4 alkoxy, C1-5 cycloalkyl or 5-membered heterocycle, wherein the optional substitution is with one or more R3B, each R3B is, independently, C1-4 alkyl, amino, cyano, halo, or hydroxyl, R4 is -R4A or -OR4A R4A is: -C 1-10 alkyl-N (R4C) 2, -C 1-10 alkyl-N (R4C) C (O) R4C, -C 1-10 alkyl-C (O) N (R4C) 2, -C 1-10 alkyl- C (O) N (R4C) -C0-6-alkyl-C (O) R4C, -C1-10-C (O) N (R4C) -C0-6-alkyl-C (O) N (R4C) 2, -C1-10-alkyl-N (R4C) C (O) -C0-6-alkyl-N (R4C) 2, or -C1-10-N alkyl (R4C) C (O) -C0-6-N alkyl (R4C) C (O) R4C each R4C is, independently, amino, amido, azo, carbonyl, carboxyl, cyano, formyl, guanidino, halo, hydroxyl, imido, imino, isothiocyanate, nitrile, nitro, nitroso, nitroxy, oxo, sulfanyl, sulfinyl, sulfonyl, thial, thiocyanate, thione, thiourea, urea, or X1, X1-L1-X2, or X1-L1-X2-L2-X3, wherein each of X1, X2, and X3 is independently optionally substituted C1-4 alkyl , C1-6 cycloalkyl, 5- or 6-membered heterocycle, or aryl, wherein the optional substitution is with one or more R4D, and each of L1 and L2 is independently optionally substituted C1-6 alkyl or heteroalkyl of 1 to 10 elements, in which the optional substitution is with one or more R4E, each R4D is, independently, R4E or C1-6 alkyl optionally substituted with one or more R4E, and each R4E is independently amino, amido, azo, carbonyl, carboxyl, cyano, formyl, guanidino, halo, hydroxyl, imido, imino, isothiocyanate, nitrile, nitro , nitroso, nitroxy, oxo, sulfanyl, sulfinyl, sulfonyl, thial, thiocyanate, thione or urea, for use as a medicament.