3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivatives as kinase inhibitors

A compound selected from the group consisting of: 3- [4 - ({[(2-fluoro-5-methylphenyl) amino] carbonyl} amino) phenyl] -5 - ({[(3-methoxypropyl) amino] carbonyl} amino) isothiazole-4-carboxamide; Ethyl {4- (aminocarbonyl) -3- [4 - ({[(2-fluoro-5-methylphenyl) amino] carbonyl} amino) phenyl] isothiazol-5-yl} carbamate; 3- [4 - ({[(2-fluoro-5-methylphenyl) amino] carbonyl} amino) phenyl] -5 - ({[(3-morpholin-4-ylpropyl) amino] carbonyl} amino) isothiazole-4- carboxamide; 3- {4- [3- (2-Fluoro-5-methyl-phenyl) -ureido] -2-methyl-phenyl} -5- [3- (3-morpholin-4-yl-propyl) - acid amide ureido] -isothiazole-4-carboxylic; 3- [3- (4-carbamoyl-3- {4- [3- (2-fluoro-5-methyl-phenyl) -ureido] -phenyl} -isothiazol-5-yl) -ureido] -propionic acid; 3- [3- (4-carbamoyl-3- {4- [3- (2-fluoro-5-methyl-phenyl) -ureido] -2-methyl-phenyl} -isothiazol-5-yl) -ureido] acid -propionic; 3- [4 - ({[(3-methylphenyl) amino] carbonyl} amino) phenyl] -5 - ({[(3-morpholin-4-ylpropyl) amino] carbonyl} amino) isothiazole-4-carboxamide; 3- [2-methyl-4- (3-m-tolyl-ureido) -phenyl] -5- [3- (3-morpholin-4-yl-propyl) -ureido] -isothiazole-4-carboxylic acid amide ; 3- (3- {4-carbamoyl-3- [4- (3-m-tolyl-ureido) -phenyl] -isothiazol-5-yl} -ureido) -propionic acid; 3- (3- {4-carbamoyl-3- [2-methyl-4- (3-m-tolyl-ureido) -phenyl] -isothiazol-5-yl} -ureido) -propionic acid; 3- {4 - [({[2-fluoro-5- (trifluoromethyl) phenyl] amino} carbonyl) amino] phenyl} -5 - ({[(3-morpholin-4-ylpropyl) amino] carbonyl} amino) isothiazole -4-carboxamide; 3- {4- [3- (2-Fluoro-5-trifluoromethyl-phenyl) -ureido] -2-methyl-phenyl} -5- [3- (3-morpholin-4-yl-propyl) - acid amide ureido] -isothiazole-4-carboxylic; 3- [3- (4-carbamoyl-3- {4- [3- (2-fluoro-5-trifluoromethyl-phenyl) -ureido] -phenyl} -isothiazol-5-yl) -ureido] -propionic acid; 3- [3- (4-carbamoyl-3- {4- [3- (2-fluoro-5-trifluoromethyl-phenyl) -ureido] -2-methylphenyl} -isothiazol-5-yl) -ureido] -propionic acid ; 3- {4 - [(anilinocarbonyl) amino] phenyl} -5 - ({[(3-morpholin-4-ylpropyl) amino] carbonyl} amino) isothiazole-4-carboxamide; 3- [2-methyl-4- (3-phenyl-ureido) -phenyl] -5- [3- (3-morpholin-4-yl-propyl) -ureido] -isothiazole-4-carboxylic acid amide; 3- (3- {4-carbamoyl-3- [4- (3-phenyl-ureido) -phenyl] -isothiazol-5-yl} -ureido) -propionic acid; 3- (3- {4-carbamoyl-3- [2-methyl-4- (3-phenyl-ureido) -phenyl] -isothiazol-5-yl} -ureido) -propionic acid; 3- [4 - ({[(4-methylphenyl) amino] carbonyl} amino) phenyl] -5 - ({[(3-morpholin-4-ylpropyl) amino] carbonyl} amino) isothiazole-4-carboxamide; 3- [2-methyl-4- (3-p-tolyl-ureido) -phenyl] -5- [3- (3-morpholin-4-yl-propyl) -ureido] -isothiazole-4-carboxylic acid amide ; 3- (3- {4-carbamoyl-3- [2-methyl-4- (3-p-tolyl-ureido) -phenyl] -isothiazol-5-yl} -ureido) -propionic acid; 3- (3- {4-carbamoyl-3- [4- (3-p-tolyl-ureido) -phenyl] -isothiazol-5-yl} -ureido) -propionic acid; 5 - ({[(3-morpholin-4-ylpropyl) amino] carbonyl} amino) -3- (4 - {[3- (trifluoromethyl) benzoyl] amino} phenyl) isothiazole-4-carboxamide; 3- [4 - ({[(4-methylphenyl) amino] carbonyl} amino) phenyl] -5 - {[(2-oxopyrrolidin-1-yl) carbonyl] amino} isothiazole-4-carboxamide; 4 - {[({4- (aminocarbonyl) -3- [4 - ({[(4-methylphenyl) amino] carbonyl} amino) phenyl] isothiazol-5-yl} amino) carbonyl] amino} butanoic acid; Methyl 4 - {[({4- (aminocarbonyl) -3- [4 - ({[(4-methylphenyl) amino] carbonyl} amino) phenyl] isothiazol-5-yl} amino) carbonyl] amino} butanoate; 5 - ({[(3-hydroxypropyl) amino] carbonyl} amino) -3- [4 - ({[(4-methylphenyl) amino] carbonyl} amino) phenyl] isothiazole-4-carboxamide; 5-amino-3- [4 - ({[(4-methylphenyl) amino] carbonyl} amino) phenyl] isothiazole-4-carboxamide; 5-amino-3- [4 - ({[(2-fluoro-5-methylphenyl) amino] carbonyl} amino) phenyl] isothiazole-4-carboxamide; and 3- [4 - ({[(4-methylphenyl) amino] carbonyl} amino) phenyl] -5 - ({[(3-pyrrolidin-1-ylpropyl) amino] carbonyl} amino) isothiazole-4-carboxamide; or a pharmaceutically acceptable salt thereof.