ES2776889T3

Substituted heterocycle fused gamma-carbolines synthesis

Abstract

Use of a compound of formula 2G ': ** (See formula) ** where: (i) k is 1 or 2; (ii) m is 0, 1 or 2; (iii) n is 1, 2 or 3; (iv) B is a protecting group; (v) R5 is H or C1-C4 alkyl; (vi) R7, R8, and R9 are independently H or optionally substituted C1-C6 alkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, hydroxy, C1-C6 alkoxy, nitro, halo, C1-C6 haloalkyl, aryl, aryl C1- C6, heteroaryl or C1-C6 heteroarylalkyl; (vii) XY is a ** (See formula) ** (viii) R10 is H or C1-4 alkyl, in free or salt form, in the manufacture of a compound of Formula 2J: ** (See formula) * * where: (i) k is 1 or 2 ;: (ii) m is 0, 1 or 2 ;: (iii) n is 1, 2 or 3 ;: (iv) X is N ;: (v) R5 is H or C1-C4 alkyl ;: (vi) R7, R8 and R9 are independently H or optionally substituted C1-C6 alkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, hydroxy, C1-6 alkoxy, nitro, halo, C1-C6 haloalkyl, aryl, arylC1-alkyl C6, heteroaryl or C1-C6 heteroarylalkyl ;: (vii) R10 is H or C1-4 alkyl ;: ...

Term

1.5 yearsto projected expiry

Projected expiry 12 March 2028, counted from filing; an application has no term until it is granted.

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