Substituted heterocycle fused gamma-carbolines synthesis
Abstract
Use of a compound of formula 2G ': ** (See formula) ** where: (i) k is 1 or 2; (ii) m is 0, 1 or 2; (iii) n is 1, 2 or 3; (iv) B is a protecting group; (v) R5 is H or C1-C4 alkyl; (vi) R7, R8, and R9 are independently H or optionally substituted C1-C6 alkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, hydroxy, C1-C6 alkoxy, nitro, halo, C1-C6 haloalkyl, aryl, aryl C1- C6, heteroaryl or C1-C6 heteroarylalkyl; (vii) XY is a ** (See formula) ** (viii) R10 is H or C1-4 alkyl, in free or salt form, in the manufacture of a compound of Formula 2J: ** (See formula) * * where: (i) k is 1 or 2 ;: (ii) m is 0, 1 or 2 ;: (iii) n is 1, 2 or 3 ;: (iv) X is N ;: (v) R5 is H or C1-C4 alkyl ;: (vi) R7, R8 and R9 are independently H or optionally substituted C1-C6 alkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, hydroxy, C1-6 alkoxy, nitro, halo, C1-C6 haloalkyl, aryl, arylC1-alkyl C6, heteroaryl or C1-C6 heteroarylalkyl ;: (vii) R10 is H or C1-4 alkyl ;: ...
Term
1.5 yearsto projected expiry
Projected expiry 12 March 2028, counted from filing; an application has no term until it is granted.
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74 members in 12 offices
Priority claims9
| Document | Office | Kind | Date |
|---|---|---|---|
| 906473P | United States of America | – | |
| 90647307 | United States of America | P | |
| 90647307 | United States of America | P | |
| 2008003340 | United States of America | W | |
| 2008003340 | United States of America | W | |
| 906473P | – | – | – |
| PCTUS2008003340 | – | – | – |
| US20070906473P | – | – | – |
| WO2008US03340 | – | – | – |
Members74
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| AU2008226814A1 | Australia | A1 | |
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| MX2020001497A | Mexico | A | |
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| KR102107954B1 | Republic of Korea | B1 | |
| KR20200047755A | Republic of Korea | A | |
| DK2134710T3 | Denmark | T3 | |
| EP3663294A1 | European Patent Office (EPO) | A1 | |
| ES2776889T3This record | Spain | T3 | |
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| US11407751B2 | United States of America | B2 | |
| MX2022008904A | Mexico | A | |
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Numbers
- Publication
- 2776889
- Publication, DOCDB
- 2776889
- Publication, EPODOC
- ES2776889T
- Application
- 8742074
- Application, DOCDB
- 08742074
- Application, EPODOC
- ES20080742074T
Titles2
- Spanish
- Síntesis de gamma-carbolinas condensadas a heterociclo sustituido
- English
- Synthesis of gamma-carbolines fused to substituted heterocycle
Classification
- CPC, 19
- C07D471/04
- C07D471/16
- A61P1/00
- A61P1/04
- A61P15/00
- A61P15/10
- A61P25/00
- A61P25/04
- A61P25/06
- A61P25/18
- A61P25/20
- A61P25/22
- A61P25/24
- A61P25/26
- A61P3/04
- A61P43/00
- C07D471/02
- C07D471/12
- C07D471/14
- IPC, 2
- C07D471 04
- C07D471 16