Nova Patents
ES2146253T3

Biologically active tgf-beta1 and tgf-beta2 peptides

Abstract

THE INVENTION REFERS TO PEPTIDES CORRESPONDING TO REGIONS OF THE AMINO ACID SEQUENCE OF TGF- {BE} 1 AND TGF- {BE} 2, WHICH KEEP, WELL IN MONOMERIC OR POLYMER FORMS, AT LEAST SOME OF THE BIOLOGICAL ACTIVITY OF TGF- {BE } REGARDING COMPLETE LENGTH. THE MONOMERIC FORM OF THE PEPTIDE DERIVED FROM TFG- {BE} 1, INCLUDES THE FOLLOWING AMINO ACID SEQUENCE: CVRQLYIDFRKDLGWKWIHEPKGYHANFCLGP. THE MONOMERICAL FORM OF THE PEPTIDE DERIVED FROM TGF- {BE} 2, INCLUDES THE FOLLOWING AMINO ACID SEQUENCE: CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGA. THE DIMENSIONS CAN BE FORMED BY MEANS OF DISULFIDE LINKS BETWEEN AMINO-TERMINAL CYSTEIN RESIDUES, CARBOXITERMINAL CYSTEINE RESIDUES, OR AMINO- AND CARBOXY-TERMINAL CYSTEINE RESIDUES OF MONOMERIC SUBUNITIES.

Term

Term ended

Projected expiry passed 21 January 2014, 12.7 years ago.

  1. Priority
  2. Filed
  3. Published
  4. Projected expiry
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22 members in 8 offices

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Priority claims5

Priority claims
DocumentOfficeKindDate
19930009448United States of America–
944893United States of AmericaA
944893United States of AmericaA
94907287–––
US19930009448–––

Members22

Family members, oldest first
DocumentOfficeKind
US4323822AUnited States of AmericaA
CA2153789A1CanadaA1
WO9417099A2World Intellectual Property Organization (WIPO)A2
AU6093294AAustraliaA
WO9417099A3World Intellectual Property Organization (WIPO)A3
US5420243AUnited States of AmericaA
JPH08510443AJapanA
US5658883AUnited States of AmericaA
EP0791011A2European Patent Office (EPO)A2
AU4097797AAustraliaA
AU685084B2AustraliaB2
AU697916B2AustraliaB2
JPH10329501AJapanA
EP0791011B1European Patent Office (EPO)B1
DE69424576D1GermanyD1
ES2146253T3This recordSpainT3
US6120104AUnited States of AmericaA
DE69424576T2GermanyT2
JP2001080302AJapanA
JP3170592B2JapanB2
JP3763479B2JapanB2
CA2153789CCanadaC