Annuloplasty systems and locking tools therefor

CROSS-REFERENCES TO RELATED APPLICATIONS

0001The present application is claims priority from: <ol id="ol0001"><li>a) <patcit id="pcit0001" dnum="US62697186"><text>US Provisional Patent Application 62/697,186 to Brauon et al., entitled: "Annuloplasty system and locking tool therefor," filed on July 12, 2018</text></patcit>; and</li><li>b) <patcit id="pcit0002" dnum="US62811693"><text>US Provisional Patent Application 62/811,693 to Brauon et al., entitled: "Annuloplasty system and locking tool therefor," filed on February 28, 2019</text></patcit>.</li></ol>

0002Both of these applications are incorporated herein by reference.

FIELD OF THE INVENTION

0003The present invention relates in general to valve repair, for example, to repair of an atrioventricular valve of a patient.

BACKGROUND

0004Ischemic heart disease can cause valvular regurgitation. For example, mitral regurgitation can be caused by the combination of ischemic dysfunction of the papillary muscles, and the dilatation of the left ventricle that is present in ischemic heart disease, with the subsequent displacement of the papillary muscles and the dilatation of the mitral valve annulus.

0005Dilation of the annulus of the mitral valve can prevent the valve leaflets from fully coapting when the valve is closed. Mitral regurgitation of blood from the left ventricle into the left atrium results in increased total stroke volume and decreased cardiac output, and ultimate weakening of the left ventricle secondary to a volume overload and a pressure overload of the left atrium.

SUMMARY

0006This summary is meant to provide some examples and is not intended to be limiting of the scope of the invention in any way. For example, any feature included in an example of this summary is not required by the claims, unless the claims explicitly recite the features. Also, the features, components, steps, concepts, etc. described in examples in this summary and elsewhere in this disclosure can be combined in a variety of ways. The description herein relates to systems, assemblies, methods, devices, apparatuses, combinations, etc. that may be utilized for valve repair. Various features and steps as described elsewhere in this disclosure can be included in the examples summarized here.

0007In some applications, a multi-component tubular system is provided for accessing a heart of a patient. The system can comprise one or more steerable guiding catheters (e.g., 1, 2, 3, or more) configured for directing the passage of devices therethrough into the heart. The multi-component tubular system can be configured to deliver an implant in a desired orientation to an annulus of a cardiac valve of the patient and to facilitate anchoring of the implant to the annulus. For some applications, the guiding system can be advanced/advanceable transluminally or transthoracically accessing an atrium of the heart. For some applications, the guiding system can be advanced surgically. The system can comprise two or more steerable catheters. A first catheter has a distal portion that is steerable to a first desired spatial orientation. A second catheter is disposed within the first catheter and has a distal portion that is steerable to a second desired spatial orientation. The system provides techniques and relative-spatial-orientation-controlling devices for controlling the orientation of the distal portion of the second catheter with respect to the first catheter without substantially distorting the first spatial orientation of the distal portion of the first catheter. For some applications, the relative-spatial-orientation-controlling device comprises a rotational locking mechanism provided by components of the catheter system.

0008The distal portion of the first catheter can be steered in a suitable direction following advancement of the first catheter through vasculature of the patient. Following the advancement of the first catheter and steering of the distal portion of the first catheter in any one or more suitable planes, the second catheter is advanced through the first catheter. The first and second catheters can be rotationally locked in order to enable steering of the distal portion of the second catheter in any one or more suitable planes with respect to the distal portion of the first catheter in a manner which substantially maintains the spatial orientation of the first catheter during the steering of the second catheter. Additionally, the first catheter can be further steered without substantially disrupting the spatial orientation of the distal portion of the second catheter.

0009The distal portions and//or distal ends of the first and second catheters can be configured such that once they have been positioned within an atrium of the heart of the patient, an implantable, adjustable annuloplasty structure (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, or other annuloplasty device) can be deployed, e.g., from within the second catheter and anchored to the annulus of the cardiac valve of the patient. The annuloplasty structure can comprise a flexible primary body portion and a contracting member having a first portion extending along a longitudinal length of the primary body portion. A second portion of the contracting member can extend away from the primary body portion of the annuloplasty structure and outside the body of the patient. From a location outside the body of the patient, contracting-member-snare of a contracting-member-uptake tool is used to ensnare a proximal end portion of the contracting member that is disposed outside of the body of the patient. Using the snare, the proximal end portion of the contracting member can then be fed through a distal portion of a primary tube of the tool and subsequently through a lumen of a secondary tube of the tool. The contracting-member-uptake-tool can then be advanced toward the annulus of the patient along the contracting member. During the advancing of the tool toward the annulus, the secondary tube of the tool can move distally along the contracting member as the contracting member passes through the lumen of the secondary tube of the tool by being pulled by the snare.

0010The contracting-member-uptake-tool can comprise an ejector movable a distal end portion of the tool. The ejector can be removably coupled to a suture fastener which comprises a clamping structure that can be flexed to an open condition through which the contracting member can pass and is biased toward a closed position or closed state which clamps onto the contracting member passed therethrough. The tool can have at least one stop that maintains the suture fastener (e.g., the clamping structure thereof) in its open condition.

0011The snare portion can be configured or adapted to capture and pull the contracting member proximally through the suture fastener and out of the aligned ports in the tool. The tool can then be advanced toward the annuloplasty structure implanted along the annulus. The tool can then uptake successive portions of the contracting member in order to contract the annuloplasty structure. Subsequently, the ejector of the tool can be moved and converts the suture fastener (e.g., the clamping structure thereof) from its open condition to its closed condition to clamp onto the contracting member passed therethrough.

0012The tool can comprise a handle portion which can comprise a contracting-member-uptake device which uptakes successive portions of the contracting member. The handle portion can comprise a tension meter configured to measure a degree of tension of the contracting member.

0013For some applications, an annuloplasty structure (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, or other annuloplasty device) comprises a primary body portion comprising a contractible sleeve, a contracting member threaded along the contractible sleeve, and a housing comprising a fastener through which the contracting member passes. Once the annuloplasty structure or annuloplasty ring structure has been contracted, the fastener is deployed within the housing in order to maintain contraction of the annuloplasty structure or annuloplasty ring structure.

0014A contracting-member-severing tool is provided in which severing of the contracting member running through the tool is possible only once the contracting member has been locked in place by a fastener coupled thereto. The contracting-member-severing tool can be configured in a variety of ways to apply a cutting surface to the contracting member, e.g., with a sharp edge that moves toward the contracting member; multiple edges and/or surfaces that move relative to each other such as in a scissoring motion or like a wire cutter tool; etc.

0015There is therefore provided, in accordance with some applications, a system and/or an apparatus, including an implantable annuloplasty structure. The annuloplasty structure including a primary body portion and a contracting member. In some implementations, the contracting member can have (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary portion of the annuloplasty structure.

0016The system and/or apparatus can include a contracting-member-uptake tool. The contracting-member-uptake tool can include a primary tube terminating at a distal end portion of the contracting-member-uptake tool, the distal end portion of the contracting-member-uptake tool having a distal tip, and a secondary tube disposed alongside the primary tube, the secondary tube having a secondary-tube lumen being configured for passage therethrough of the contracting member. In some implementations, the contracting-member-uptake tool also includes a contracting-member snare including a distal snare portion and an elongate flexible body portion coupled to the distal snare portion, the distal snare portion being configured to ensnare a portion of the contracting member. The contracting-member snare can be sized to pass through the secondary-tube lumen of the secondary tube in order to pull the second portion of the contracting member through a length of the secondary tube.

0017For some applications, the distal snare portion is configured to pull the second portion of the contracting member through the distal tip of the contracting-member-uptake tool and subsequently through the length of the secondary tube.

0018For some applications, the contracting-member-snare includes a wire including stainless steel. For some applications, the contracting-member-snare includes a wire having a diameter of 0.2-0.25 mm.

0019For some applications, the primary tube and/or the secondary tube is flexible.

0020For some applications, the annuloplasty structure defines a full annuloplasty ring structure. For some applications, the annuloplasty structure defines a partial annuloplasty ring structure.

0021For some applications, the secondary tube is shaped to define a longitudinal slit.

0022For some applications, the contracting-member-uptake tool includes a handle portion and the first and second tubes are connected to the handle portion.

0023For some applications, the handle portion includes a contracting-member-uptake device configured to uptake successive portions of the contracting member; and a tension meter configured to measure a degree of tension of the contracting member.

0024For some applications, the contracting-member-uptake device is actuatable to increase tension of the contracting member.

0025For some applications, the contracting-member-uptake device includes a knob coupled to a proximal portion of the contracting member, the knob being configured to increase tension of the contracting member by pulling the contracting member proximally. For some applications, the knob is fixedly coupled to the proximal portion of the contracting member.

0026For some applications, the contracting-member-uptake device includes a wheel having a groove configured to couple the contracting member to the wheel. For some applications, the groove is shaped so as to receive a middle portion of the contracting member.

0027For some applications, the secondary-tube lumen of the secondary tube is sized so as to maintain coupling between the distal snare portion and the contracting member.

0028For some applications, the snare portion includes a flexible loop, and the secondary-tube-lumen is configured to collapse the loop around the contracting member as the elongate flexible body portion is pulled through the secondary-tube-lumen. For some applications, the secondary-tube lumen of the secondary tube has a diameter of 0.5-1.5 mm.

0029For some applications, the contracting-member-snare includes a metal wire.

0030For some applications, at least the distal snare portion of the contracting-member-snare is corrugated to increase friction between the snare portion and the contracting member.

0031For some applications, the distal snare portion is configured pull the second portion of the contracting member through an entire length of the secondary tube.

0032For some applications, the contracting member-uptake tool includes: at least one contracting-member-fastener disposed within the distal end portion of the contracting-member-uptake tool, the contracting-member-fastener including a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move; and a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state.

0033For some applications, the at least one contracting-member-fastener includes at least first and second contracting-member-fastener disposed within the distal end portion of the contracting-member-uptake tool.

0034For some applications, the distal snare portion and the elongate flexible body portion of the contracting-member-snare are sized to pass distally through the contracting-member-fastener in the open state, the snare portion being adapted to capture and pull the contracting member proximally through the contracting-member-fastener and through aligned ports in the distal end portion of the contracting-member-uptake tool.

0035For some applications, the contracting-member-uptake tool includes a fastener-ejector movable within the distal end portion of the contracting-member-uptake tool, and movement of the fastener-ejector contacts and converts the contracting-member-fastener from the open state to the closed state to clamp onto the contracting member passed therethrough.

0036For some applications, the fastener-ejector is coupled to the stop and moves the stop that is removably coupled to the fastener.

0037For some applications, the distal end portion of the contracting-member-uptake tool is shaped so as to define a sharp edge, and the contracting member is disposed in proximity to the sharp edge such that movement of the fastener-ejector against the sharp edge severs the contracting member extending through the fastener.

0038For some applications, the system and/or apparatus further includes: at least one contracting-member-fastener configured to surround the contracting member, the contracting-member-fastener including a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move; and a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state.

0039For some applications, the contracting-member-uptake tool includes a fastener-ejector movable within the distal end portion of the contracting-member-uptake tool, and movement of the fastener-ejector is configured to convert the contracting-member-fastener from the open state to the closed state to clamp onto the contracting member passed therethrough.

0040For some applications, the fastener-ejector is removably coupled to the stop and moves the stop that is removably coupled to the fastener.

0041For some applications, the tool includes a moveable cutting element having a sharp edge, and movement of the stop hammers the stop against the moveable cutting element such that movement of the moveable cutting element severs the contracting member extending through the fastener and through the moveable cutting element.

0042For some applications, the system and/or apparatus further includes a lock slidable along the contracting member, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member. The lock can be shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock. The lock can define a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock. The lock lumen can be configured to surround the contracting member. In some applications, when the lock is compressed, the slit enables the lock to close around the contracting member and thereby lock the lock to the contracting member.

0043For some applications, the annuloplasty structure is shaped so as to define a recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.

0044For some applications, the recess is dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.

0045For some applications, the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion of the lock lumen.

0046For some applications, the recess is shaped so as to define a proximal portion that is narrower than any other portion of the recess distal to the proximal portion.

0047For some applications, the lock is disposed within the distal end portion of the contracting-member-uptake tool.

0048For some applications, when the contracting-member-uptake tool is coupled to the annuloplasty structure, the lock is disposed at least in part within the recess.

0049For some applications, when the contracting-member-uptake tool is coupled to the annuloplasty structure, the lock is disposed entirely proximally to the recess.

0050For some applications, the lock is disposed within the distal end portion of the contracting-member-uptake tool.

0051For some applications, the distal snare portion and the elongate flexible body portion of the contracting-member-snare are sized to pass distally through lock, the snare portion adapted to capture and pull the contracting member proximally through the lock and through aligned ports in the distal end portion of the contracting-member-uptake tool.

0052There is further provided, in accordance with some applications, a system and/or an apparatus, including an implantable annuloplasty structure. The implantable annuloplasty structure including a primary body portion and a contracting member. The contracting member can have (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty ring structure, and (2) a second portion extending away from the primary body portion of the annuloplasty ring structure.

0053The system and/or apparatus can also include a housing configured to be positionable against the primary body portion of the annuloplasty ring structure.

0054The system and/or apparatus can also include a contracting-member-fastener disposed at least in part within the housing, the contracting-member-fastener including a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move.

0055The system and/or apparatus can also include a stop removably coupled to the fastener and configured to maintain the contracting-member-fastener in the open state; and a fastener-ejector engageable with the stop such that movement of the fastener-ejector moves the stop removably coupled to the fastener and converts the clamping structure from the open state to the closed state to clamp onto the contracting member passed therethrough.

0056For some applications, the fastener-ejector is shaped such that movement thereof facilitates severing of the contracting member extending through the fastener.

0057For some applications, the fastener includes a deformable element having a slanted state and a straight state, the stop is configured to maintain the fastener in the slanted state, and, upon removal of the stop, the fastener is configured to transition to the straight state and claim the contracting member between the fastener and a surface of the housing.

0058For some applications, the fastener is shaped so as to define a plurality of teeth configured to increase friction between the contracting member and the fastener.

0059There is further provided, in accordance with some applications, a method, including advancing toward a heart of a patient an implantable annuloplasty structure including a primary body portion and a contracting member. The contracting member be the same as or similar to other contracting members herein and can have (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary portion of the annuloplasty ring structure.

0060The method further includes threading the second portion of the contracting member through a contracting-member-uptake tool. The contracting-member-uptake tool can include a primary tube terminating at a distal end portion of the contracting-member-uptake tool, the distal end portion of the contracting-member-uptake tool having a distal tip and a secondary tube disposed alongside the primary tube, the secondary tube having a secondary-tube lumen being configured for passage therethrough of the contracting member. The contracting-member-uptake tool can also include a contracting-member-snare including a distal snare portion and an elongate flexible body portion coupled to the distal snare portion, the distal snare portion being configured to ensnare a portion of the contracting member and being sized to pass through the secondary-tube lumen of the secondary tube in order to pull the second portion of the contracting member through a length of the secondary tube.

0061For some applications, the threading includes using the distal snare portion, ensnaring the portion of the contracting member; using the contracting-member-snare, pulling the portion of the contracting member through the secondary tube; and subsequently to the threading, advancing the contracting-member-uptake tool along the contracting member toward the annuloplasty structure.

0062For some applications, threading the second portion of the contracting member includes threading the second portion of the contracting member subsequently to the advancing.

0063For some applications, pulling the portion of the contracting member through the secondary tube includes pulling the second portion of the contracting member through the distal tip of the contracting-member-uptake tool and subsequently through the length of the secondary tube.

0064For some applications, pulling the portion of the contracting member through the secondary tube includes strengthening a coupling between the contracting member and the snare portion.

0065For some applications, the method further includes, subsequently to the advancing of the contracting-member-uptake tool, contracting the annuloplasty structure using the contracting-member-uptake tool.

0066For some applications, contracting the annuloplasty structure using the contracting-member-uptake tool includes advancing successive portions of the contracting member with respect to a contracting-member-uptake device.

0067For some applications, the method further includes, subsequently to the contracting, maintaining the annuloplasty structure in a contracted state by clamping a contracting-member-fastener around a portion of the contracting member.

0068For some applications, clamping includes deploying the fastener from within the distal end portion of the contracting-member-uptake tool.

0069For some applications, the method further includes, subsequently to the maintaining the annuloplasty structure in the contracted state, using a sharp edge of the contracting-member-uptake tool, severing the contracting member.

0070For some applications, advancing the contracting-member-uptake tool includes advancing the contracting-member-uptake tool through vasculature of the patient.

0071For some applications, contracting-member-uptake tool includes a handle portion including a contracting-member-uptake device configured to uptake successive portions of the contracting member; and a tension meter configured to measure a degree of tension of the contracting member.

0072For some applications, the method further includes increasing tension of the contracting member using the contracting-member-uptake device.

0073For some applications, the contracting-member-uptake device includes a wheel and having a groove, and the method further includes coupling the contracting member to the wheel.

0074For some applications, coupling the contracting member to the wheel includes coupling a middle portion of the contracting member to the wheel.

0075The method can be performed in a procedure on a living animal or in a simulation/simulated procedure (e.g., on a cadaver, cadaver heart, simulator with a simulated heart, tissue, etc., anthropomorphic ghost, etc.).

0076There is further provided, in accordance with some applications, a method, including advancing toward a heart of a patient an implantable annuloplasty structure. The implantable annuloplasty structure can be the same as or similar to other annuloplasty structures herein or otherwise known, and can include, for example, a primary body portion, a contracting member, and a housing coupled to the primary body portion of the annuloplasty structure. For some applications the contracting member has (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary body portion of the annuloplasty structure.

0077For some applications, a contracting-member-fastener is disposed within the housing, the contracting-member-fastener including a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move. For some applications, a stop is removably coupled to the fastener and configured to maintain the contracting-member-fastener in the open state.

0078For some applications, the method further includes converting the contracting-member-fastener from the open state to the closed state in order to clamp onto the contracting member passed therethrough by moving a fastener-ejector engageable with the stop such that movement of the fastener-ejector moves the stop removably coupled to the fastener.

0079For some applications, the method further includes, subsequently to the advancing, contracting the annuloplasty structure using the contracting member, and converting the contracting-member-fastener from the open state to the closed state including converting subsequently to the contracting.

0080For some applications, contracting the annuloplasty structure includes contracting the annuloplasty structure using a contracting-member-uptake tool.

0081For some applications, contracting the annuloplasty structure using the contracting-member-uptake tool includes advancing successive portions of the contracting member with respect to a contracting-member-uptake device.

0082For some applications, the method further includes, subsequently to the converting of the contracting-member-fastener from the open state to the closed state, using a sharp edge of the contracting-member-uptake tool, severing the contracting member.

0083The method can be performed in a procedure on a living animal or in a simulation/simulated procedure (e.g., on a cadaver, cadaver heart, simulator with a simulated heart, tissue, etc., anthropomorphic ghost, etc.).

0084There is further provided, in accordance with some applications, a system, including an implantable annuloplasty structure including a primary body portion and a contracting member extending at least partially along a longitudinal length of the primary body portion of the annuloplasty structure. The system also includes a contracting-member-uptake tool. The contracting-member-uptake tool can include a tube having a lumen configured for passage therethrough of the contracting member and a contracting-member-snare. The contracting-member snare can include a distal snare portion and an elongate flexible body portion coupled to the distal snare portion, the distal snare portion being configured to ensnare a portion of the contracting member and pull it into the lumen.

0085For some applications, the distal snare portion is configured to pull the portion of the contracting member through an entire length of the lumen.

0086For some applications, the contracting-member-snare includes a wire including stainless steel. For some applications, the tube is flexible.

0087For some applications, the contracting-member-uptake tool includes a handle portion and the tube is connected to the handle portion.

0088For some applications, the handle portion includes a contracting-member-uptake device configured to uptake successive portions of the contracting member; and a tension meter configured to measure a degree of tension of the contracting member.

0089For some applications, the contracting-member-uptake device is actuatable to increase tension of the contracting member.

0090For some applications, the contracting-member-uptake device includes a wheel having a groove configured to couple the contracting member to the wheel.

0091For some applications, the groove is shaped so as to receive a middle portion of the contracting member.

0092For some applications, the lumen of the tube is sized so as to maintain coupling between the distal snare portion and the contracting member.

0093For some applications, the distal snare portion includes a flexible loop, and the lumen is configured to collapse the loop around the contracting member as the portion of the contracting member is pulled through the lumen.

0094For some applications, at least the distal snare portion of the contracting-member-snare is corrugated to increase friction between the snare portion and the contracting member.

0095For some applications, the distal end portion of the contracting-member-uptake tool is shaped so as to define a sharp edge, and the contracting member-uptake tool is configured to dispose the contracting member in proximity to the sharp edge such that the sharp edge can sever the contracting member.

0096For some applications, the contracting member-uptake tool includes: <ul id="ul0001" list-style="none" compact="compact"><li>a contracting-member-fastener disposed within the distal end portion of the contracting-member-uptake tool, the contracting-member-fastener including a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move; and</li><li>a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state.</li></ul>

0097For some applications, the distal snare portion and the portion of the contracting-member are sized to pass distally through the contracting-member-fastener in its open state, the distal snare portion being adapted to capture and pull the portion of the contracting member proximally through the contracting-member-fastener and through aligned ports in the distal end portion of the contracting-member-uptake tool.

0098For some applications, the contracting-member-uptake tool includes a fastener-ejector movable within the distal end portion of the contracting-member-uptake tool, and movement of the fastener-ejector contacts and can convert the contracting-member-fastener from its open state to its closed state to clamp onto the contracting member when passed therethrough.

0099For some applications, the fastener-ejector is coupled to the stop and moves the stop that is removably coupled to the fastener.

0100For some applications, the distal end portion of the contracting-member-uptake tool is shaped so as to define a sharp edge, and the contracting-member-uptake tool is configured to dispose the contracting member in proximity to the sharp edge such that movement of the fastener-ejector against the sharp edge severs the contracting member after where it extends through the fastener.

0101For some applications, the implantable annuloplasty structure is a closed annuloplasty structure.

0102There is further provided, in accordance with some applications, a system and/or apparatus, including an implantable annuloplasty structure including a primary body portion having a lateral wall and a contracting member. In some applications, the contracting member has (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary body portion of the annuloplasty structure, the contracting member being configured to adjust a perimeter of the annuloplasty structure.

0103The primary body portion of the annuloplasty structure can be shaped to define a recess having a recess axis, the recess extending from an opening in a first surface of the lateral wall of the primary body portion toward an opposite second surface of the lateral wall of the primary body portion, the lateral wall of the primary body portion extending away from the recess along a longitudinal axis that is at a non-zero angle with respect to the recess axis, the contracting member extending through the recess and away from the primary body portion of the annuloplasty structure via the recess.

0104The system and/or apparatus can include a lock slidable along the contracting member and toward the recess, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member, the recess being shaped so as to facilitate fixed coupling of the lock to the contracting member.

0105For some applications, the lock is disposable at least in part within the recess.

0106For some applications, the annuloplasty structure includes a full annuloplasty ring structure; in others the annuloplasty structure includes a partial annuloplasty ring structure.

0107For some applications, the lock is configured to lock the contracting member when the lock is moved at least in part within the recess.

0108For some applications, the lock is configured to fit entirely within the recess.

0109For some applications the primary body portion includes a housing, the housing defines at least a portion of the lateral wall, and the housing defines the recess.

0110For some applications, the lock is shaped so as to define a lock-threaded-portion, and the annuloplasty structure is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.

0111For some applications, the recess defines a recess lumen extending along the recess axis. For some applications, the recess axis is disposed at the non-zero angle.

0112For some applications the lock is shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock, the lock defines a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock, the lock lumen is configured to surround the contracting member, and when the lock is disposed within the recess, the slit enables the lock to close around the contracting member and thereby lock the lock to the contracting member.

0113For some applications, the recess is dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.

0114For some applications, the slit is shaped so as to define a distal portion that is wider than a proximal portion of the slit.

0115For some applications, the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion of the lock lumen.

0116For some applications, the recess is shaped so as to define a proximal-most portion that is narrower than any other portion of the recess distal to the proximal-most portion.

0117For some applications, the annuloplasty structure includes a housing, and the housing is shaped so as to define the recess, the recess having a recess axis.

0118For some applications, the lock is shaped so as to define a lock-threaded-portion, and the housing is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.

0119For some applications, the housing is shaped so as to define a contracting-member lumen that is disposed at a non-zero angle with respect to the recess axis.

0120For some applications, the housing is shaped so as to provide a contracting-member-lumen wall which is disposed along the contracting-member lumen, and when the lock is disposed within the recess, a distal end of the lock is configured to pinch a first portion of the contracting member against the contracting-member-lumen wall in order to lock the contracting member at least a first pinching point.

0121For some applications the recess is shaped so as to define a recess-distal-tapered-portion. For some applications, the lock is shaped so as to define a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock, and a lock-distal-tapered-portion. The lock lumen can be configured to surround the contracting member.

0122For some applications, when the lock is disposed within the recess, the recess-distal-tapered-portion is configured to compress the lock-distal-tapered-portion which, in turn, is configured to pinch a second portion of the contracting member within the lock lumen at the recess-distal-tapered-portion in order to lock the contracting member at least a second pinching point.

0123For some applications, the system and/or apparatus further includes a delivery tool, the delivery tool and the contracting member being slidable with respect to each other, the delivery tool being configured to deliver the annuloplasty structure to an annulus of a heart of a patient.

0124For some applications, the delivery tool includes a knob coupled to a proximal portion of the contracting member, the knob being configured to increase tension of the contracting member by pulling the contracting member proximally.

0125For some applications, the knob is fixedly coupled to the proximal portion of the contracting member.

0126For some applications, when the delivery tool is coupled to the annuloplasty structure, a portion of the contracting member is disposed within a lumen of the delivery tool and the lock surrounds a part of the contracting member.

0127For some applications, when the delivery tool is coupled to the annuloplasty structure, the lock is disposed at least in part within the recess.

0128For some applications, when the delivery tool is coupled to the annuloplasty structure, the lock is disposed entirely proximally to the recess.

0129For some applications, the delivery tool includes a lock-ejector movable within a distal end portion of the delivery tool, and movement of the lock-ejector contacts and converts the lock from an open state to a closed state to clamp onto the contracting member passed therethrough.

0130For some applications, the distal end portion of the delivery tool is shaped so as to define a sharp edge, and the contracting member is disposed in proximity to the sharp edge such that movement of the lock-ejector against the sharp edge severs the contracting member extending through the lock.

0131There is further provided, in accordance with some applications, a system and/or an apparatus, including an implantable annuloplasty structure including a primary body portion and a contracting member. The contracting member can be the same as or similar to other contracting members herein and can, for example, have a (1) first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and a (2) second portion extending away from the primary portion of the annuloplasty structure. The system and/or apparatus can include a lock slidable along the contracting member, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member. The lock can be shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock.

0132For some applications, the lock defines a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock. The lock lumen can be configured to surround the contracting member. When the lock is compressed, the slit can enable the lock to close around the contracting member and thereby lock the lock to the contracting member.

0133For some applications, the annuloplasty structure includes a full annuloplasty ring structure, in others, the annuloplasty structure includes a partial annuloplasty ring structure.

0134For some applications, the annuloplasty structure is shaped so as to define a recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.

0135For some applications, the lock is disposable at least in part within the recess.

0136For some applications, the lock is configured to fit entirely within the recess.

0137For some applications, the slit is shaped so as to define a distal portion that is wider than a proximal portion of the slit.

0138For some applications, the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion of the lock lumen.

0139For some applications, the recess is shaped so as to define a proximal portion that is narrower than any other portion of the recess distal to the proximal portion.

0140For some applications, the lock is shaped so as to define a lock-threaded-portion, and the annuloplasty structure is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.

0141For some applications, the annuloplasty structure includes a housing, and the housing is shaped so as to define the recess, the recess having a recess axis.

0142For some applications, the lock is shaped so as to define a lock-threaded-portion, and the housing is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.

0143For some applications, the housing is shaped so as to define a contracting-member lumen that is disposed at a non-zero angle with respect to the recess axis.

0144For some applications, the housing is shaped so as to provide a contracting-member-lumen wall which is disposed along the contracting-member lumen, and when the lock is disposed within the recess, a distal end of the lock is configured to pinch a first portion of the contracting member against the contracting-member-lumen wall in order to lock the contracting member at least a first pinching point.

0145For some applications the recess is shaped so as to define a recess-distal-tapered-portion, and the lock is shaped so as to define a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock, and a lock-distal-tapered-portion. The lock lumen can be configured to surround the contracting member. When the lock is disposed within the recess, the recess-distal-tapered-portion can be configured to compress the lock-distal-tapered-portion which, in turn, is configured to pinch a second portion of the contracting member within the lock lumen at the recess-distal-tapered-portion in order to lock the contracting member at least a second pinching point.

0146For some applications, the system and/or apparatus further includes a delivery tool, the delivery tool and the contracting member being slidable with respect to each other, the delivery tool being configured to deliver the annuloplasty structure to an annulus of a heart of a patient.

0147For some applications, the delivery tool includes a knob coupled to a proximal portion of the contracting member, the knob being configured to increase tension of the contracting member by pulling the contracting member proximally.

0148For some applications, the knob is fixedly coupled to the proximal portion of the contracting member.

0149For some applications, when the delivery tool is coupled to the annuloplasty structure, a portion of the contracting member is disposed within a lumen of the delivery tool and the lock surrounds a part of the contracting member.

0150For some applications, the annuloplasty structure is shaped so as to define a recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess, and when the delivery tool is coupled to the annuloplasty structure, the lock is disposed at least in part within the recess.

0151For some applications, the annuloplasty structure is shaped so as to define a recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess, and when the delivery tool is coupled to the annuloplasty structure, the lock is disposed entirely proximally to the recess.

0152For some applications, the delivery tool includes a lock-ejector movable within a distal end portion of the delivery tool, and movement of the lock-ejector contacts and converts the lock from an open state to a closed state to clamp onto the contracting member passed therethrough.

0153For some applications, the distal end portion of the delivery tool is shaped so as to define a sharp edge, and the contracting member is disposed in proximity to the sharp edge such that movement of the lock-ejector against the sharp edge severs the contracting member extending through the lock.

0154There is further provided, in accordance with some applications, a method, including advancing toward a heart of a patient an implantable annuloplasty structure. The implantable annuloplasty structure can be the same as or similar to other annuloplasty structures herein or otherwise known, such as for example, having a primary body portion having a lateral wall and a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary body portion of the annuloplasty structure, the contracting member being configured to adjust a perimeter of the annuloplasty structure.

0155The primary body portion of the annuloplasty structure can be shaped to define a recess having a recess axis, the recess extending from an opening in a first surface of the lateral wall of the primary body portion toward an opposite second surface of the lateral wall of the primary body portion, the lateral wall of the primary body portion extending away from the recess along a longitudinal axis that is at a non-zero angle with respect to the recess axis, the contracting member extending through the recess and away from the primary body portion of the annuloplasty structure via the recess; and

0156The method can further include locking the contracting member by sliding a lock along the contracting member to fit within the recess, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member, the recess being shaped so as to facilitate fixed coupling of the lock to the contracting member.

0157For some applications, advancing includes advancing the annuloplasty structure while the lock is disposed at least in part within the recess.

0158For some applications, advancing includes advancing the annuloplasty structure while the lock is disposed entirely proximally to the recess.

0159For some applications, locking the contracting member includes sliding the lock fully within the recess.

0160For some applications, the annuloplasty structure includes a full annuloplasty ring structure or a partial annuloplasty ring structure.

0161For some applications the lock is shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock, the lock defines a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock, the lock lumen is configured to surround the contracting member, and when the lock is disposed within the recess, the slit enables the lock to close around the contracting member and thereby lock the lock to the contracting member.

0162For some applications, the recess is dimensioned so as to compress the lock when the lock is disposed at least in part within the recess, and locking includes positioning the lock at least in part within the recess so as to compress the lock.

0163For some applications, the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion of the lock lumen.

0164For some applications, the recess is shaped so as to define a proximal portion that is narrower than any other portion of the recess distal to the proximal portion.

0165For some applications, advancing includes advancing the annuloplasty structure using a delivery tool, and the method further includes sliding the delivery tool and the contracting member with respect to each other.

0166For some applications, advancing includes advancing the lock within the delivery tool and locking includes sliding the lock using the delivery tool.

0167For some applications, the delivery tool includes a knob coupled to a proximal portion of the contracting member, and the method further includes using the knob, increasing tension of the contracting member by pulling the contracting member proximally.

0168For some applications, the knob is fixedly coupled to the proximal portion of the contracting member.

0169For some applications, the delivery tool includes a lock-ejector movable within a distal end portion of the delivery tool, and the method further includes clamping the lock onto the contracting member passed therethrough by moving the lock-ejector to contact and convert the lock from an open state to a closed state.

0170For some applications the distal end portion of the delivery tool is shaped so as to define a sharp edge, the contracting member is disposed in proximity to the sharp edge, moving the lock-ejector includes moving the lock-ejector against the sharp edge, and severing the contracting member extending through the lock by the moving of the lock-ejector against the sharp edge.

0171The method can be performed in a procedure on a living animal or in a simulation/simulated procedure (e.g., on a cadaver, cadaver heart, simulator with a simulated heart, tissue, etc., anthropomorphic ghost, etc.).

0172There is further provided, in accordance with some applications, a method, including advancing toward a heart of a patient an implantable annuloplasty structure. The annuloplasty structure can be the same as or similar to other annuloplasty structures herein or otherwise known, and can, for example, include a primary body portion having a lateral wall and a contracting member. The contracting member can have (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary body portion of the annuloplasty structure, the contracting member being configured to adjust a perimeter of the annuloplasty structure.

0173The method further includes locking the contracting member by sliding a lock along the contracting member, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member. The lock can be shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock. The lock can define a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock. The lock lumen can be configured to surround the contracting member. For some applications, when the lock is compressed, the slit enables the lock to close around the contracting member and thereby lock the lock to the contracting member.

0174For some applications, the annuloplasty structure includes a full annuloplasty ring structure or a partial annuloplasty ring structure.

0175For some applications, the annuloplasty structure is shaped so as to define a recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess, and locking the contracting member includes sliding the lock at least in part within the recess.

0176For some applications, advancing includes advancing the annuloplasty structure while the lock is disposed at least in part within the recess.

0177For some applications, advancing includes advancing the annuloplasty structure while the lock is disposed entirely proximally to the recess.

0178For some applications, locking the contracting member includes sliding the lock fully within the recess.

0179For some applications, the recess is dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.

0180For some applications, the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion of the lock lumen.

0181For some applications, the recess is shaped so as to define a proximal portion that is narrower than any other portion of the recess distal to the proximal portion.

0182For some applications, advancing includes advancing the annuloplasty structure using a delivery tool, and the method further includes sliding the delivery tool and the contracting member with respect to each other.

0183For some applications, advancing includes advancing the lock within the delivery tool and locking includes sliding the lock using the delivery tool.

0184For some applications, the delivery tool includes a knob coupled to a proximal portion of the contracting member, and the method further includes using the knob, increasing tension of the contracting member by pulling the contracting member proximally.

0185For some applications, the knob is fixedly coupled to the proximal portion of the contracting member.

0186For some applications, the delivery tool includes a lock-ejector movable within a distal end portion of the delivery tool, and the method further includes clamping the lock onto the contracting member passed therethrough by moving the lock-ejector to contact and convert the lock from an open state to a closed state.

0187For some applications the distal end portion of the delivery tool is shaped so as to define a sharp edge, the contracting member is disposed in proximity to the sharp edge, moving the lock-ejector includes moving the lock-ejector against the sharp edge, and severing the contracting member extending through the lock by the moving of the lock-ejector against the sharp edge.

0188The method can be performed in a procedure on a living animal or in a simulation/simulated procedure (e.g., on a cadaver, cadaver heart, simulator with a simulated heart, tissue, etc., anthropomorphic ghost, etc.)

0189There is further provided, in accordance with some applications, a system and/or an apparatus, including an implantable annuloplasty structure including a primary body portion and a contracting member. The contracting member can be the same as or similar to other contracting members herein or otherwise known, and can, for example, have (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary portion of the annuloplasty structure.

0190The system and/or apparatus further comprising at least one contracting-member-fastener configured to surround the contracting member. the contracting-member-fastener can include a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move.

0191The system and/or apparatus further comprising a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state and a contracting-member-severing tool. The contracting-member-severing tool can include a static cutting element having a first cutting surface, a dynamic cutting element having a second cutting surface that opposes the first cutting surface, and one or more graspers configured to pull the stop proximally and remove the stop from the contracting-member-fastener. For some applications, a portion of the contracting member passes through the static cutting element and through the dynamic cutting element, and once pulled proximally, the stop contacts the cutting element and is configured to push against and move the dynamic cutting element with respect to the static cutting element in order to facilitate severing of the contracting member.

0192For some applications, the first and second cutting surfaces are each concave. For some applications, the first and second cutting surfaces are each diagonal.

0193For some applications, the tool is arranged such that the tool provides a safety mechanism whereby movement of the dynamic cutting element with respect to the static cutting element is possible only with pushing of the stop against the dynamic cutting element.

0194For some applications, the system and/or apparatus further includes a housing that houses the fastener and the stop, and the tool is coupled to the housing as the graspers grasp the stop.

0195For some applications, the tool is configured to deliver the housing, the fastener, and the stop to the implantable annuloplasty structure.

0196For some applications, the implantable annuloplasty structure includes the housing.

0197For some applications, the stop is shaped so as to define an overhang, and the graspers are configured to grip the overhang in order to initially couple the tool to the fastener.

0198For some applications, the system and/or apparatus further includes an outer sleeve portion configured to surround the graspers in order to lock the graspers with respect to the overhang.

0199There is further provided, in accordance with some applications, a system and/or an apparatus, including a contracting-member fastener configured to fasten to a contracting member. For some applications, at least one contracting-member-fastener is configured to surround the contracting member. The contracting-member-fastener can include a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move.

0200The system and/or apparatus can include a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state.

0201The system and/or apparatus can include a contracting-member-severing tool. The contracting-member-severing tool can include a cutting element configured to cut the contracting member and one or more graspers configured to pull the stop proximally and remove the stop from the contracting-member-fastener. For some applications, once pulled proximally, the stop contacts the cutting element and is configured to push against and move the cutting element in order to facilitate severing of the contracting member by the cutting element.

0202For some applications, the tool is arranged such that the tool provides a safety mechanism whereby movement of the cutting element is possible only with pushing of the stop against the cutting element.

0203For some applications, the system and/or apparatus further includes a housing that houses the fastener and the stop, and the tool is coupled to the housing as the graspers grasp the stop.

0204For some applications, the system and/or apparatus further includes an implantable annuloplasty structure, the tool is configured to deliver the housing, the fastener, and the stop to the implantable annuloplasty structure.

0205For some applications, the system and/or apparatus further includes an implantable annuloplasty structure, the implantable annuloplasty structure includes the housing.

0206For some applications, the stop is shaped so as to define an overhang, and the graspers are configured to grip the overhang in order to initially couple the tool to the fastener.

0207For some applications, the system and/or apparatus further includes an outer sleeve portion configured to surround the graspers in order to lock the graspers with respect to the overhang.

0208There is further provided, in accordance with some applications, a method, including threading a contracting-member-severing tool along a contracting member, the contracting-member-severing tool including a cutting element in proximity with the contracting member during the threading. The method can also include engaging the tool with a stop that is removably coupled to a contracting-member-fastener surrounding a portion of the contracting member, the stop being configured to maintain the contracting-member-fastener in an open state.

0209For some applications, the method further includes using the tool, disengaging the stop from the contracting-member-fastener by pulling the stop with the tool, and by the pulling, contacting the stop with the cutting element and facilitating pushing of the stop against the cutting element, and by the pushing, facilitating moving of the cutting element, and thereby facilitating severing of the contracting member by the cutting element.

0210For some applications, the tool is arranged such that the tool provides a safety mechanism whereby the moving of the cutting element is possible only by the pushing of the stop against the cutting element.

0211For some applications, the method further includes a housing that houses the fastener and the stop, and the method includes coupling the tool to the housing by gasping the stop with the tool.

0212For some applications, the method further includes, using the tool, delivering the housing, the fastener, and the stop to an implantable annuloplasty structure.

0213For some applications, coupling the tool to the housing includes coupling the tool the housing that is coupled to an implantable annuloplasty structure.

0214For some applications, the stop is shaped so as to define an overhang, and engaging the tool with a stop includes initially coupling the tool to the fastener by gripping the overhang with the tool with graspers.

0215For some applications, the method further includes locking the graspers with respect to the overhang by passing an outer sleeve portion over the graspers.

0216The method can be performed in a procedure on a living animal or in a simulation/simulated procedure (e.g., on a cadaver, cadaver heart, simulator with a simulated heart, tissue, etc., anthropomorphic ghost, etc.)

0217There is further provided, in accordance with some applications, a system and/or an apparatus including an implant including an implantable structure and a flexible elongated contracting member that extends away from the implantable structure; and a contracting-member-uptake tool, which includes a handle portion, which includes an outer housing, a tubular shaft, disposed at least partially within the outer housing, and an inner shaft.

0218For some application, the inner shaft (a) is partially disposed within a proximal longitudinal portion of the tubular shaft, such that the inner shaft is axially slidable with respect to the tubular shaft, (b) is shaped so as to define an inner-shaft contracting-member-receiving channel, and (c) includes a lock, which is configured (i) when in an unlocked state, to allow sliding of the contracting member with respect to the inner-shaft contracting-member-receiving channel, and (ii) when in a locked state, to axially lock the contracting member with respect to the inner shaft.

0219For some applications, the system and/or apparatus (e.g., in the handle) further includes a distal force applicator, which (a) is disposed at least partially within a distal longitudinal portion of the tubular shaft, and (b) is shaped so as to define a distal-force-applicator contracting-member-receiving channel, which allows sliding of the contracting member therethrough.

0220For some applications, the system and/or apparatus (e.g., in the handle) further includes a spring, which is disposed within the tubular shaft, connecting the distal force applicator and a distal portion of the inner shaft; and a contraction-facilitating knob, which is accessible from outside the outer housing,

0221For some applications, the handle portion is shaped so as to define a handle contracting-member-receiving channel from a distal end through to a proximal end of the handle portion, the handle contracting-member-receiving channel includes the inner-shaft contracting-member-receiving channel and the distal-force-applicator contracting-member-receiving channel,

0222For some applications, the handle portion is configured such that actuation of the contraction-facilitating knob, when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel and the lock is in the locked state, causes the handle portion to uptake successive portions of the contracting member by advancing the tubular shaft proximally with respect to the outer housing, which advances the distal force applicator proximally with respect to the outer housing, which applies a proximally-directed force to the spring, which pushes the inner shaft proximally with respect to the outer housing, and which proximally pulls the contracting member.

0223For some applications, the handle portion is configured such that upon the actuation of the contraction-facilitating knob when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel, the lock is in the locked state, and the contracting member is tensed: the spring pushes the inner shaft proximally with respect to the outer housing to a lesser extent than the tubular shaft proximally advances with respect to the outer housing, and proximal pulling of the contracting member by the inner shaft increases tension in the contracting member.

0224For some applications, the contraction-facilitating knob is configured to be actuated by rotation thereof.

0225For some applications, the tubular shaft and the contraction-facilitating knob are in threaded connection with each other, and the handle portion is configured such that actuation of the contraction-facilitating knob rotates the tubular shaft, thereby advancing the tubular shaft proximally with respect to the outer housing.

0226For some applications, the inner shaft partially protrudes out of a proximal end of the outer housing, and the tubular shaft and the inner shaft together provide a non-electrical mechanical force gauge, in which a relative axial position of the tubular shaft with respect to the inner shaft provides a visual indication of a measure of the tension in the contracting member.

0227For some applications, the inner shaft is marked with a plurality of fiduciary markers, which are arranged along the inner shaft to indicate the relative axial position of the tubular shaft with respect to the inner shaft.

0228For some applications, the handle portion further includes a tension-limiting locking assembly, which is configured to axially lock the inner shaft with respect to the outer housing when the handle portion increases the tension in the contracting member to a predetermined threshold level, thereby limiting a maximum tension that the inner shaft can apply to the contracting member.

0229For some applications, the tension-limiting locking assembly is configured to axially lock the inner shaft with respect to the outer housing when the tubular shaft is disposed at a predetermined relative axial position with respect to the inner shaft, thereby limiting the maximum tension that the inner shaft can apply to the contracting member.

0230For some applications, the tension-limiting locking assembly includes a detent, which is arranged to axially lock the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft, thereby limiting the maximum tension that the inner shaft can apply to the contracting member.

0231For some applications, the detent is coupled in axial fixation with the inner shaft and is configured to move radially outward so as to engage the outer housing in order to axially lock the inner shaft with respect to the outer housing.

0232For some applications, the tension-limiting locking assembly further includes a plurality of indentations that the outer housing is shaped so as to define, the detent is engageable with the indentations to axially lock the inner shaft with respect to the outer housing, and the handle portion is arranged such that the particular one of the indentations with which the detent engages depends upon a relative axial position of the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft.

0233For some applications, the proximal longitudinal portion of the tubular shaft is shaped so as to define an elongate opening through which the detent passes when the detent axially locks the inner shaft with respect to the outer housing.

0234For some applications, the tubular shaft includes one or more tracks that run alongside a longitudinal portion of the elongate opening and are arranged to: <ol id="ol0002"><li>(a) prevent the detent from axially locking the inner shaft with respect to the outer housing when the tubular shaft is disposed distally to the predetermined relative axial position with respect to the inner shaft, and</li><li>(b) allow the detent to axially lock the inner shaft when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft.</li></ol>

0235For some applications, the one or more tracks are shaped so as to define one or more respective sloping portions, such that after the detent axially locks the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft, subsequent distal motion of the tubular shaft and consequently the one or more tracks with respect to the inner shaft disengages the detent from the outer housing.

0236For some applications, the inner shaft partially protrudes out of a proximal end of the outer housing, and the tubular shaft and the inner shaft together provide a non-electrical mechanical force gauge, in which a relative axial position of the tubular shaft with respect to the inner shaft provides a visual indication of a measure of the tension in the contracting member.

0237For some applications, the implantable structure includes an implantable annuloplasty structure.

0238For some applications, the implantable annuloplasty structure includes a flexible sleeve, and the contracting member extends along and away from the sleeve.

0239There is further provided, in accordance with some applications, a system and/or an apparatus includes an implant including an implantable structure and a flexible elongated contracting member that extends away from the implantable structure; and a contracting-member-uptake tool. The contracting-member-uptake tool can include a handle portion, which (a) is shaped so as to define a handle contracting-member-receiving channel from a distal end through to a proximal end of the handle portion, and (b) includes: an outer housing; a non-electrical mechanical force gauge; a lock; and a contraction-facilitating knob, which is accessible from outside the outer housing. The lock can be configured (i) when in an unlocked state, to allow sliding of the contracting member with respect to the force gauge, and (ii) when in a locked state, to axially lock the contracting member with respect to an axially-movable portion of the force gauge, the axially-movable portion of the force gauge is axially-movable with respect to the outer housing.

0240For some applications, the handle portion is configured such that actuation of the contraction-facilitating knob, when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel and the lock is in the locked state, causes the handle portion to uptake successive portions of the contracting member by advancing the force gauge proximally with respect to the outer housing so as to proximally pull the contracting member.

0241For some applications, the handle portion is configured such that upon the actuation of the contraction-facilitating knob when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel, the lock is in the locked state, and the contracting member is tensed, proximal pulling of the contracting member by the axially-movable portion of the force gauge increases tension in the contracting member, and the force gauge is configured to provide a visual indication of a measure of the tension in the contracting member.

0242For some applications, the force gauge includes a spring.

0243For some applications, the force gauge is configured such that the spring applies a proximally-directed force to the axially-movable portion of the force gauge.

0244For some applications, the handle portion further includes a tension-limiting locking assembly, which is configured to axially lock the axially-movable portion of the force gauge with respect to the outer housing when the handle portion increases the tension in the contracting member to a predetermined threshold level, thereby limiting a maximum tension that the axially-movable portion of the force gauge can apply to the contracting member.

0245There is further provided, in accordance with some applications, a method including advancing toward a heart of a patient an implantable structure of an implant and a flexible elongated contracting member that extends away from the implantable structure, and threading a portion of the contracting member through a handle contracting-member-receiving channel of a handle portion of a contracting-member-uptake tool. The contracting-member-uptake tool can be the same as or similar to other contracting-member-uptake tools described elsewhere herein, and can, for example, include one, all, or some of an outer housing, a tubular shaft, disposed at least partially within the outer housing, an inner shaft, a distal force applicator, a spring, and a contraction-facilitating knob, which is accessible from outside the outer housing.

0246The inner shaft can (a) be partially disposed within a proximal longitudinal portion of the tubular shaft, such that the inner shaft is axially slidable with respect to the tubular shaft, (b) be shaped so as to define an inner-shaft contracting-member-receiving channel, and (c) include a lock, which is configured (i) when in an unlocked state, to allow sliding of the contracting member with respect to the inner-shaft contracting-member-receiving channel, and (ii) when in a locked state, to axially lock the contracting member with respect to the inner shaft.

0247The distal force applicator can (a) be disposed at least partially within a distal longitudinal portion of the tubular shaft, and (b) be shaped so as to define a distal-force-applicator contracting-member-receiving channel, which allows sliding of the contracting member therethrough, the handle contracting-member-receiving channel (a) extends from a distal end through to a proximal end of the handle portion, and (b) includes the inner-shaft contracting-member-receiving channel and the distal-force-applicator contracting-member-receiving channel.

0248The spring can be disposed within the tubular shaft, connecting the distal force applicator and a distal portion of the inner shaft.

0249The method further includes transitioning the lock from the unlocked state to the locked state.

0250For some applications, the method includes, thereafter, actuating the contraction-facilitating knob to cause the handle portion to uptake successive portions of the contracting member until the contracting member is tensed, by: advancing the tubular shaft proximally with respect to the outer housing, which advances the distal force applicator proximally with respect to the outer housing, which applies a proximally-directed force to the spring, which pushes the inner shaft proximally with respect to the outer housing, which proximally pulls the contracting member; and thereafter, once the contracting member is tensed, actuating the contraction-facilitating knob to increase tension in the contracting member by proximal pulling of the contracting member by the inner shaft caused by the spring pushing the inner shaft proximally with respect to the outer housing to a lesser extent than the tubular shaft proximally advances with respect to the outer housing.

0251For some applications, actuating the contraction-facilitating knob includes rotating the contraction-facilitating knob.

0252For some applications, the tubular shaft and the contraction-facilitating knob are in threaded connection with each other, and the handle portion is configured such that actuation of the contraction-facilitating knob rotates the tubular shaft, thereby advancing the tubular shaft proximally with respect to the outer housing.

0253For some applications, the inner shaft partially protrudes out of a proximal end of the outer housing, the tubular shaft and the inner shaft together provide a non-electrical mechanical force gauge, in which a relative axial position of the tubular shaft with respect to the inner shaft provides a visual indication of a measure of the tension in the contracting member, and the method further includes viewing the visual indication.

0254For some applications, the inner shaft is marked with a plurality of fiduciary markers, which are arranged along the inner shaft to indicate the relative axial position of the tubular shaft with respect to the inner shaft.

0255For some applications, the handle portion further includes a tension-limiting locking assembly, which is configured to axially lock the inner shaft with respect to the outer housing when the handle portion increases the tension in the contracting member to a predetermined threshold level, thereby limiting a maximum tension that the inner shaft can apply to the contracting member.

0256For some applications, the tension-limiting locking assembly is configured to axially lock the inner shaft with respect to the outer housing when the tubular shaft is disposed at a predetermined relative axial position with respect to the inner shaft, thereby limiting the maximum tension that the inner shaft can apply to the contracting member.

0257For some applications, the tension-limiting locking assembly includes a detent, which is arranged to axially lock the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft, thereby limiting the maximum tension that the inner shaft can apply to the contracting member.

0258For some applications, the detent is coupled in axial fixation with the inner shaft and is configured to move radially outward so as to engage the outer housing in order to axially lock the inner shaft with respect to the outer housing.

0259For some applications, the tension-limiting locking assembly further includes a plurality of indentations that the outer housing is shaped so as to define, the detent is engageable with the indentations to axially lock the inner shaft with respect to the outer housing, and the handle portion is arranged such that the particular one of the indentations with which the detent engages depends upon a relative axial position of the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft.

0260For some applications, the proximal longitudinal portion of the tubular shaft is shaped so as to define an elongate opening through which the detent passes when the detent axially locks the inner shaft with respect to the outer housing.

0261For some applications, the tubular shaft includes one or more tracks that run alongside a longitudinal portion of the elongate opening and are arranged to: <ol id="ol0003"><li>(a) prevent the detent from axially locking the inner shaft with respect to the outer housing when the tubular shaft is disposed distally to the predetermined relative axial position with respect to the inner shaft, and</li><li>(b) allow the detent to axially lock the inner shaft when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft.</li></ol>

0262For some applications, the one or more tracks are shaped so as to define one or more respective sloping portions, such that after the detent axially locks the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft, subsequent distal motion of the tubular shaft and consequently the one or more tracks with respect to the inner shaft disengages the detent from the outer housing.

0263For some applications, the inner shaft partially protrudes out of a proximal end of the outer housing, the tubular shaft and the inner shaft together provide a non-electrical mechanical force gauge, in which a relative axial position of the tubular shaft with respect to the inner shaft provides a visual indication of a measure of the tension in the contracting member, and the method further includes viewing the visual indication.

0264For some applications, the implantable structure includes an implantable annuloplasty structure, and advancing the implantable structure includes advancing the implantable annuloplasty structure toward the heart.

0265For some applications, the implantable annuloplasty structure includes a flexible sleeve, and advancing the implantable annuloplasty structure and the contracting member toward the heart such that the contracting member extends along and away from the sleeve.

0266There is further provided, in accordance with some applications, a method including advancing toward a heart of a patient an implantable structure of an implant and a flexible elongated contracting member that extends away from the implantable structure, and threading a portion of the contracting member through a handle contracting-member-receiving channel of a handle portion of a contracting-member-uptake tool.

0267The contracting-member-uptake tool can be the same as or similar to other contracting-member-uptake tools described elsewhere herein or otherwise known. For example, in some applications, the contracting-member-uptake tool comprises an outer housing, a non-electrical mechanical force gauge, a lock, and a contraction-facilitating knob. The lock can be configured (i) when in an unlocked state, to allow sliding of the contracting member with respect to the force gauge, and (ii) when in a locked state, to axially lock the contracting member with respect to an axially-movable portion of the force gauge, the axially-movable portion of the force gauge is axially-movable with respect to the outer housing. The contraction-facilitating knob can be accessible from outside the outer housing.

0268The method further includes transitioning the lock from the unlocked state to the locked state; and thereafter, actuating the contraction-facilitating knob to cause the handle portion to uptake successive portions of the contracting member by advancing the force gauge proximally with respect to the outer housing so as to proximally pull the contracting member.

0269The method can thereafter include, once the contracting member is tensed, actuating the contraction-facilitating knob to increase tension in the contracting member by proximal pulling of the contracting member by the axially-movable portion of the force gauge, and viewing a visual indication of a measure of the tension in the contracting member, the visual indication provided by the force gauge.

0270For some applications, the force gauge includes a spring.

0271For some applications, the force gauge is configured such that the spring applies a proximally-directed force to the axially-movable portion of the force gauge.

0272For some applications, the handle portion further includes a tension-limiting locking assembly, which is configured to axially lock the axially-movable portion of the force gauge with respect to the outer housing when the handle portion increases the tension in the contracting member to a predetermined threshold level, thereby limiting a maximum tension that the axially-movable portion of the force gauge can apply to the contracting member.

0273The method can be performed in a procedure on a living animal or in a simulation/simulated procedure (e.g., on a cadaver, cadaver heart, simulator with a simulated heart, tissue, etc., anthropomorphic ghost, etc.)

0274There is also provided, in accordance with some applications, a system and/or an apparatus, which can include an implantable annuloplasty structure (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, or other annuloplasty device). The implantable annuloplasty structure can comprise a primary body portion and a contracting member extending at least partially along a longitudinal length of the primary body portion of the annuloplasty structure. The implantable annuloplasty structure can be the same as or similar to other annuloplasty structures described elsewhere herein.

0275The system and/or apparatus can also comprise a contracting-member-uptake tool. The contracting-member-uptake tool can be the same as or similar to other contracting-member-uptake tools described elsewhere herein. The contracting-member-uptake tool can comprise one or more tubes (e.g., one tube, a primary tube and a secondary tube, etc.). At least one tube has a lumen configured for passage therethrough of the contracting member. The tube can be flexible, semi-rigid, or rigid. The contracting-member-uptake tool can also comprise a contracting-member-snare. The contracting-member snare can comprise a distal snare portion and an elongate flexible body portion coupled to the distal snare portion. The distal snare portion can be configured to ensnare a portion of the contracting member and pull it into the lumen. The distal snare portion can be configured to pull the portion of the contracting member through some of the lumen or through an entire length of the lumen (e.g., from end to end). The contracting-member-snare can comprise a wire comprising stainless steel. The lumen of the tube can be sized so as to maintain coupling between the distal snare portion and the contracting member.

0276The contracting-member-uptake tool can comprise a handle portion, and the tube can be connected to the handle portion. The handle portion can comprise a contracting-member-uptake device configured to uptake successive portions of the contracting member. The handle portion can also include a tension meter configured to measure a degree of tension of the contracting member. The contracting-member-uptake device can be actuatable to increase tension of the contracting member. The contracting-member-uptake device can optionally comprise a wheel having a groove configured to couple the contracting member to the wheel. The groove can be shaped so as to receive a middle portion of the contracting member.

0277The distal snare portion can comprise a flexible loop. The lumen can be configured to collapse the flexible loop around the contracting member as the portion of the contracting member is pulled through the lumen. At least the distal snare portion of the contracting-member-snare can be corrugated to increase friction between the snare portion and the contracting member.

0278The distal end portion of the contracting-member-uptake tool can be shaped so as to define a sharp edge, and the contracting member-uptake tool can be configured to dispose the contracting member in proximity to the sharp edge such that the sharp edge can sever the contracting member.

0279The contracting member-uptake tool can comprise a contracting-member-fastener disposed within the distal end portion of the contracting-member-uptake tool. The contracting-member-fastener can comprise a clamping structure. The clamping structure can be biased toward assuming a closed state or closed position, and in the closed state/position, the clamping structure can be configured to clamp onto the contracting member passed therethrough. The clamping structure can also be configured such that it can be flexed to an open state or open position, wherein in the open state/position, the contracting member can move therethrough. The contracting member-uptake tool can also comprise a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state/position.

0280The distal snare portion, the portion of the contracting-member, and the clamping structure can be configured and sized to pass distally through the contracting-member-fastener and clamping structure in the open state/position. The distal snare portion can be adapted to capture and pull the portion of the contracting member proximally through the contracting-member-fastener and clamping structure, and through aligned ports in the distal end portion of the contracting-member-uptake tool.

0281The contracting-member-uptake tool can comprise a fastener-ejector movable within the distal end portion of the contracting-member-uptake tool, which can be configured such that movement of the fastener-ejector contacts and can convert the contracting-member-fastener and clamping structure from the open state/position to the closed state/position to clamp onto the contracting member when passed therethrough. The fastener-ejector can be coupled to the stop and can be configured to move the stop that is removably coupled to the fastener. The distal end portion of the contracting-member-uptake tool can be shaped so as to define a sharp edge, and the contracting-member-uptake tool can be configured to dispose the contracting member in proximity to the sharp edge such that movement of the fastener-ejector against the sharp edge severs the contracting member after or proximate where it extends through the fastener.

0282The various apparatuses, systems, methods, etc. described above can incorporate and/or substitute various features and components of other embodiments described elsewhere herein.

0283The present inventions will be more fully understood from the following detailed description of embodiments thereof, taken together with the drawings, in which:

BRIEF DESCRIPTION OF THE DRAWINGS

0284<ul id="ul0002" list-style="none"><li><figref idref="f0001 f0002">Figs. 1-2</figref> are schematic illustrations of an example of a multi-component tubular system for delivering and anchoring an implant and for controlling a relative spatial orientation of components of the catheter system;</li><li><figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref> are schematic illustrations of an example procedure for implanting an annuloplasty structure to repair a mitral valve;</li><li><figref idref="f0009 f0010">Figs. 4A-B</figref> are schematic illustrations of an example contracting-member-uptake tool which is configured to contract a contracting member of the annuloplasty structure of <figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref> and sever any excess portions of the contracting member;</li><li><figref idref="f0011 f0012">Figs. 5A-D</figref> are schematic illustrations of the example contracting-member-uptake tool of <figref idref="f0009 f0010">Figs. 4A-B</figref> used to uptake the contracting member;</li><li><figref idref="f0013 f0014">Figs. 6A-B</figref> are schematic illustrations of the example contracting-member-uptake tool of <figref idref="f0009 f0010">Figs. 4A-B</figref> used to uptake the contracting member in order to contract the annuloplasty structure coupled to the contracting member;</li><li><figref idref="f0015 f0016">Figs. 7A-E</figref> are schematic illustrations of the example contracting-member-uptake tool of <figref idref="f0009 f0010">Figs. 4A-B</figref> used to lock and secure the annuloplasty structure in its contracted state and subsequently, sever excess portions of the contracting member;</li><li><figref idref="f0017 f0018 f0019 f0020">Figs. 8A-D</figref> are schematic illustrations of an example of a system for contracting the annulus of the patient using an annuloplasty structure comprising a housing which houses a contracting-member-fastener;</li><li><figref idref="f0021 f0022">Figs. 9A-D</figref> are schematic illustrations of an example contracting-member-uptake tool used to lock and secure the annuloplasty structure of <figref idref="f0017 f0018 f0019 f0020">Figs. 8A-D</figref> in its contracted state and subsequently, sever excess portions of the contracting member;</li><li><figref idref="f0023">Figs. 10A-B</figref> are schematic illustrations of an example of a contracting-member-uptake tool useable to engage a contracting member and sever any excess portions of the contracting member;</li><li><figref idref="f0024">Figs. 11A-C</figref> are schematic illustrations of an example of a contracting-member-uptake tool used to lock and secure the annuloplasty structure in its contracted state and subsequently, sever excess portions of the contracting member;</li><li><figref idref="f0025">Figs. 12A-C</figref> are schematic illustrations of an example of a system comprising an example annuloplasty structure comprising a sleeve, a contracting member, and a lock;</li><li><figref idref="f0026">Figs. 13A-C</figref> are schematic illustrations of an example of a system comprising an example annuloplasty structure comprising a sleeve, a contracting member, and a lock;</li><li><figref idref="f0027">Fig. 14</figref> is a schematic illustration of an example lock useable to lock a perimeter of an annuloplasty structure;</li><li><figref idref="f0028">Figs. 15A-C</figref> are schematic illustrations of an example of a system comprising an example annuloplasty structure comprising a sleeve, a contracting member, and a lock;</li><li><figref idref="f0029">Fig. 16</figref> is a schematic illustration of an example of a system comprising an example annuloplasty structure comprising a sleeve, a contracting member, and a lock;</li><li><figref idref="f0029">Fig. 17</figref> is a schematic illustration of an example of a system comprising an example annuloplasty structure comprising a sleeve, a contracting member, and a lock;</li><li><figref idref="f0030">Fig. 18</figref> is a schematic illustration of an example of a system for contracting the annulus of the patient using an annuloplasty structure comprising a housing which houses a contracting-member-fastener;</li><li><figref idref="f0031">Figs. 19A-B</figref> are schematic illustrations of an example of a system for contracting the annulus of the patient using an annuloplasty structure comprising a housing which houses a contracting-member-fastener;</li><li><figref idref="f0032 f0033 f0034">Figs. 20A-F</figref> are schematic illustrations of an example of a contracting-member-uptake and contracting-member severing tool for use with an annuloplasty structure comprising a housing which houses a contracting-member-fastener;</li><li><figref idref="f0035">Figs. 21A-B</figref> are schematic illustrations of an example of a contracting-member-uptake tool of the multi-component tubular system of <figref idref="f0032 f0033 f0034">Figs. 20A-F</figref>, before insertion of a flexible elongated contracting member, in accordance with some applications;</li><li><figref idref="f0036">Figs. 22A-B</figref> are schematic illustrations of the contracting-member-uptake tool of <figref idref="f0035">Figs. 21A-B</figref> after insertion of the flexible elongated contracting member, in accordance with some applications;</li><li><figref idref="f0037">Figs. 23A-B</figref>, <figref idref="f0038">24A-B</figref>, and <figref idref="f0039">25A-B</figref> are schematic illustrations of the contracting-member-uptake tool of <figref idref="f0035">Figs. 21A-B</figref> after successive levels of actuation of a contraction-facilitating knob of the tool, in accordance with some applications; and</li><li><figref idref="f0040">Figs. 26A-B</figref> are schematic illustrations of a portion of an outer housing and a tubular shaft of the contracting-member-uptake tool of <figref idref="f0035">Figs. 21A-B</figref>, in accordance with some applications.</li></ul>

DETAILED DESCRIPTION OF EMBODIMENTS

0285Reference is now made to <figref idref="f0001 f0002">Figs. 1-2</figref>, which are schematic illustrations of an example of a multi-component tubular system 10 providing one or more rotationally-controlled steering catheters configured for delivering an implant to a heart of a patient. System 10 provides an implant-delivery tool. System 10 can comprise a first, outer catheter 12 comprising a sheath configured for advancement through vasculature of a patient. For some applications, outer catheter 12 comprises a sheath configured for advancement through a femoral artery toward an interatrial septum of a heart of a patient. A distal steerable end portion of outer catheter 12 is configured to pass through the septum and be oriented in a desired spatial orientation. System 10 comprises a second catheter, or guide catheter 14, comprising a steerable distal end portion. Catheter 14 is configured for advancement through a lumen of outer catheter 12. Outer catheter 12 provides a first coupling 152 (e.g., a slit 52) at a distal portion thereof (e.g., a portion of catheter 12 that is proximal to the steerable distal end portion). Guide catheter 14 can comprise a second coupling 154 (e.g., a depressible engager 54) that is coupled to a displaceable tab 56 coupled to a base. As is described herein, depressible engager 54 (or the second coupling 154) is configured so as to protrude within slit 52 (or the first coupling 152). Thus, slit 52 defines a second-coupling-receiving element.

0286In some embodiments, first coupling 152 of catheter 12 defines a longer coupling, the second coupling 154 of catheter 14 defines a shorter coupling. The first and second couplings 152 and 154 of outer catheter 12 and guide catheter 14, respectively, enable axial advancement and rotational motion of guide catheter 14 through the lumen of outer catheter 12 until engager 54 of catheter 14 is aligned with and engages slit 52 of catheter 12, as will be described hereinbelow. As shown in cross-section A-A of <figref idref="f0001">Fig. 1</figref>, guide catheter 14 is configured to be concentrically disposed within a lumen of outer catheter 12. In some embodiments, catheter 12 provides the shorter coupling, and catheter 14 provides the longer coupling. For example, catheter 14 can be shaped so as to provide slit 52, and catheter 12 can comprise engager 54, which is configured to engage slit 52 of catheter 14.

0287As shown in the exploded view of view B, first coupling 152 can be shaped so as to define slit 52. For some applications, slit 52 is provided by a metal frame 50, as shown. Metal frame 50 can have a length L22 of, for example, between 7 and 15 mm, e.g., 13 mm. For such applications, a slit is created in material of catheter 12 (e.g., by creating a slit in the polymer material of catheter 12 during manufacturing of catheter 12), and frame 50 is coupled to catheter 12. Second coupling 154 can comprise an engager 54 which can comprise a protrusion disposed at a distal portion of displaceable tab 56 of a base of engager 54. The base of engager 54 can be shaped so as to define slits 57 which form tab 56. Engager 54 is depressible when a force is applied thereto, and tab 56 facilitates movement of engager 54 in response to and in the absence of force applied to engager 54. For some applications, during manufacture of catheter 14, catheter 14 is manipulated in order to couple thereto engager 54 and tabs 56, e.g., engager 54 and tabs 56 are embedded within the polymer of catheter 14.

0288Although slit 52 and a depressible engager 54 are shown on outer catheter 12 and guide catheter 14, respectively, at distal portions of catheters 12 and 14, slit 52 and engager 54 can be provided along any suitable portion of catheters 12 and 14, respectively (e.g., respective proximal portions of catheters 12 and 14).

0289First and second couplings 152 and 154, respectively, can be provided on any standard catheter. That is, coupling 152 comprises frame 50 which can be coupled to an external surface of any standard catheter (in which case, a corresponding slit would be made in the standard catheter). Additionally coupling 154 can be coupled to any standard catheter by coupling the base portion of coupling 154 to any standard catheter. Suitable adjustments to the standard catheter would be made to accommodate the displacing of tab 56 and engager 54 in response to pushing forces applied to engager 54.

0290<figref idref="f0002">Fig. 2</figref> shows an example concentric relationship between components of tubular system 10 (in an exploded view on the left side of <figref idref="f0002">Fig. 2</figref>). As described hereinabove, a distal end portion of outer catheter 12 is steerable. The distal end portion of outer catheter 12 can comprise a pull ring 11 that is coupled to two or more steering or pull wires 29a and 29b, that are disposed within respective secondary lumens within a wall of catheter 12 (as shown in section A-A). As shown in the exploded view, guide catheter 14 can be configured to be concentrically disposed within the lumen of catheter 12. As described hereinabove, the distal end portion of guide catheter 14 is steerable. The distal end portion of catheter 14 can comprise a pull ring 13 that is coupled to two or more pull wires 31a and 31b, that are disposed within respective secondary lumens within a wall of catheter 14 (as shown in sections A-A and B-B).

0291Guide catheter 14 is steerable to a desired spatial orientation in order to facilitate advancing and implantation of an implant in a body cavity of the patient. As shown, the implant comprises an annuloplasty structure 222 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) comprising a flexible sleeve 26 (shown in the exploded view of <figref idref="f0002">Fig. 2</figref>). Sleeve 26 can comprise a braided fabric mesh, e.g., comprising DACRON (TM). Sleeve 26 can be configured to be placed only partially around a cardiac valve annulus (i.e., to assume a C-shape), and, once anchored in place, to be contracted so as to circumferentially tighten the valve annulus. Although, the ring structure can also be configured to be placed entirely around the valve annulus. In order to tighten the annulus, annuloplasty structure or annuloplasty ring structure 222 comprises a flexible elongate contracting member 226 that extends along sleeve 26. Elongate contracting member 226 can comprise a wire, a ribbon, a rope, or a band, which can comprise one or more of a variety of materials, for example, a flexible and/or superelastic material, e.g., nitinol, polyester, stainless steel, or cobalt chrome. For some applications, the wire comprises a radiopaque material. For some applications, contracting member 226 comprises a braided polyester suture (e.g., Ticron). For some applications, contracting member 226 is coated with polytetrafluoroethylene (PTFE). For some applications, contracting member 226 comprises a plurality of wires that are intertwined to form a rope structure.

0292For applications in which system 10 is used to deliver an implant to the mitral valve of the patient, outer catheter 12 can be configured for initial advancement through vasculature of the patient until a distal end 102 (which can be a distal-most end or tip) of catheter 12 is positioned in the left atrium. The distal steerable end portion of catheter 12 is then steered such that distal end 102 of catheter 12 is positioned in a desired spatial orientation within the left atrium. The steering procedure can be performed with the aid of imaging, such as fluoroscopy, transesophageal echo, and/or echocardiography. Following the steering of the distal end portion of catheter 12, guide catheter 14 (which houses annuloplasty structure 222) is advanced through catheter 12 in order to facilitate delivery and implantation of structure 222 along the annulus of the mitral valve. During the delivery, at least a portion of the steerable distal end portion of catheter 14 can be exposed from distal end 102 of catheter 12 and is thus free for steering toward the annulus of the mitral valve, as is described hereinbelow.

0293In addition, system 10 comprises an attachment mechanism (e.g., anchor(s), adhesive, clamp(s), clip(s), fastener(s), etc.), such as a plurality of anchors 32, which can be, for example, between about 5 and about 20 anchors, such as about 10 or about 16 anchors. Each anchor 32 can comprise a tissue-engaging element 60 (e.g., a helical tissue-engaging element), and a tool-coupling head 62, fixed to one end of the tissue-engaging element. One anchor 32 is shown in <figref idref="f0002">Fig. 2</figref> as being reversibly coupled to a deployment element 38 of a rotating anchor driver 36 of an anchor deployment manipulator 61. When sleeve 26 is disposed along the annulus of the cardiac valve, deployment manipulator 61 is configured to advance within a lumen of sleeve 26 and deploy each anchor 32 from within sleeve 26 through a wall of sleeve 26 and into cardiac tissue, thereby anchoring sleeve 26 around a portion of the valve annulus. The insertion of the anchors into the sleeve and deployment of the anchors into cardiac tissue is described in detail hereinbelow.

0294Anchors 32 can comprise a biocompatible material, such as stainless steel 316 LVM. For some applications, anchors 32 comprise nitinol. For some applications, anchors 32 are coated fully or partially with a non-conductive material.

0295Deployment manipulator 61, as shown in <figref idref="f0002">Fig. 2</figref>, comprises anchor driver 36 and deployment element 38.

0296As shown in the exploded view of <figref idref="f0002">Fig. 2</figref>, sleeve 26 is disposed within a lumen of guide catheter 14. A force is applied to a proximal end of sleeve 26 by a distal end of a reference-force tube 19. As shown, an implant-decoupling channel 18 is advanceable within a lumen of reference-force tube 19 and through a lumen of sleeve 26 such that a portion of channel 18 that is disposed within the sleeve is coaxial with the sleeve. As shown in the enlarged image of <figref idref="f0001">Fig. 1</figref>, a distal end 17 of implant-decoupling channel 18 is disposed in contact with an inner wall of sleeve 26 at a distal end thereof. Additionally, a distal end portion of channel 18 comprises a radiopaque marker 1018. As shown, tube 19 and sleeve 26 are longitudinally and coaxially disposed with respect to each other.

0297Anchor driver 36 can be advanced within channel 18. For some applications, system 10 comprises a plurality of anchor drivers 36, each driver being coupled to a respective anchor 32. Each driver 36 can be advanced within channel 18 in order to advance and implant anchor 32 in tissue. Following implantation of anchor 32, anchor 32 is decoupled from driver 36, as described herein, and driver 36 is removed from within channel 18. Subsequently, a new driver 36 coupled to another anchor 32 is then advanced within channel 18.

0298As will be described hereinbelow, a first anchor 32 is configured to be deployed through the wall of the sleeve into cardiac tissue, when sleeve 26 is positioned along the annulus of the valve. Following the deployment of the first anchor, a distal portion of sleeve 26 is slid distally off a portion of implant-decoupling channel 18. In order to decouple sleeve 26 distally from a portion of outer surface of channel 18, (1) a proximal force is applied to channel 18, while (2) reference-force tube 19 is maintained in place in a manner in which a distal end of tube 19 provides a reference force to sleeve 26 in order to facilitate freeing of a successive portion of sleeve 26 from around channel 18. Channel 18 is then positioned at a successive location within the lumen of sleeve 26 while either tube 19 and/or catheter 14 is steered toward a successive location along the annulus of the valve (as will be described hereinbelow). Consequently, the successive portion of sleeve 26 provides a free lumen for advancement of a successive anchor 32 and deployment of the anchor through the wall of the sleeve at the successive portion thereof. Such freeing of the successive portion of sleeve 26 creates a distance between successive anchors deployed from within the lumen of sleeve 26.

0299For some applications, sleeve 26 comprises a plurality of radiopaque markers 25, which are positioned along the sleeve at respective longitudinal sites. The markers can provide an indication in a radiographic image (such as a fluoroscopy image) of how much of the sleeve has been deployed at any given point during an implantation procedure, in order to enable setting a desired distance between anchors 32 along the sleeve. For some applications, the markers comprise a radiopaque ink.

0300Often, at least a portion (e.g., three, at least three, some, all, etc.) of the longitudinal sites of the radiopaque markers are longitudinally spaced at a constant interval. The longitudinal distance between the distal edges of adjacent markers, and/or the distance between the proximal edges of adjacent markers, can be set equal to the desired distance between adjacent anchors. For example, the markers can comprise first, second, and third markers, which first and second markers are adjacent, and which second and third markers are adjacent, and the distance between the proximal and/or distal edges of the first and second markers equal the corresponding distance between the proximal and/or distal edges of the second and third markers. For example, the distance can be between 3 and 15 mm, such as 6 mm, and the longitudinal length of each marker can be between 0.1 and 14 mm, such as 2 mm. (If, for example, the distance were 6 mm and the length were 2 mm, the longitudinal gaps between adjacent markers would have lengths of 4 mm.)

0301Each anchor 32 can be coupled to deployment element 38 of anchor driver 36. Anchor driver 36 comprises an elongate tube having at least a flexible distal end portion. The elongate tube of driver 36 extends within a lumen of channel 18, through system 10 toward a proximal end of a proximal handle portion 101 of system 10. The tube of anchor driver 36 provides a lumen for slidable advancement therethrough of an elongate rod 130. Rod 130 facilitates the locking and unlocking of anchor 32 to deployment element 38, as is described hereinbelow. As shown in Section E-E of <figref idref="f0002">Fig. 2</figref>, a proximal end of rod 130 is coupled to a component of an anchor-release mechanism 28 at a proximal end of system 10. Mechanism 28 comprises a housing 135 and a finger-engager 131 that is coupled to the proximal end of rod 130. Finger-engager 131 is coupled to a housing 135 via a spring 133 (section E-E of <figref idref="f0002">Fig. 2</figref>). A proximal end of the tube of anchor driver 36 is coupled to housing 135. As is described hereinbelow, the user (e.g., a physician, health care professional, etc.) releases anchor 32 from deployment element 38 when finger-engager 131 is pulled proximally, thereby pulling rod 130 proximally.

0302For some applications, anchor driver 36 (e.g., rotation and/or proximal-distal movement thereof, and/or release of anchor 32) is electronically controllable, such as by using an extracorporeal controller and/or electric motor coupled to a proximal end of the anchor driver and/or housing 135.

0303Proximal handle portion 101 can be supported by a stand having support legs 91 and a handle-sliding track 90. Handle portion 101 comprises an outer-catheter handle 22, a guide-catheter handle 24, an implant-manipulating handle 126, and anchor-release mechanism 28. Handle 22 is coupled to a proximal end of outer catheter 12. Handle 24 is coupled to a proximal portion of guide catheter 14. Handle 126 is coupled to a proximal portion of reference-force tube 19, and linear movement of handle 126 with respect to handle 24 moves reference-force tube 19 (and thereby typically structure 222) through catheter 14. As described hereinabove, housing 135 of anchor-release mechanism 28 is coupled to a proximal portion of the tube of anchor driver 36. The relative positioning of each of the concentrically-disposed components of system 10 is shown in the exploded view and sections A-A, B-B, C-C, and D-D of <figref idref="f0002">Fig. 2</figref>.

0304The stand supporting proximal handle portion 101 can be moved distally and proximally to control a position of the entire multi-component system 10, particularly so as to adjust a distance of distal end 102 of catheter 12 from the interatrial septum. Handle 22 comprises a steering knob 210 that is coupled to pull wires 29a and 29b disposed within respective secondary lumens in the wall of outer catheter 12. Rotation of knob 210 adjusts a degree of tension of wires 29a and 29b which, in turn, apply a force to pull ring 11 at the distal end portion of outer catheter 12. Such force steers the distal end portion of catheter 12 within the atrium of the heart of the patient in a manner in which the distal end portion of catheter 12 is steered in a first plane that is parallel with the plane of the annulus of the valve (e.g., in a direction from the interatrial septum toward surrounding walls of the atrium). For some applications, the distal end portion of catheter 12 can be pre-shaped so as to point downward toward the valve. For other applications, the distal end portion of catheter 12 can be pulled to assume an orientation in which the distal end portion points downward toward the valve. For some applications, the distal end portion of catheter 12 is not made to point downward toward the valve.

0305Handle 24 can be coupled to track 90 via a first mount 92. Mount 92 can be slidable proximally and distally along track 90 in order to control an axial position of guide catheter 14 with respect to outer catheter 12. Mount 92 can be slidable via a control knob 216. For example, control knob 216 of mount 92 can control the proximal and distal axial movement of the distal steerable portion of guide catheter 14 with respect to distal end 102 of outer catheter 12. Handle 24 can comprise a steering knob 214 that is coupled to pull wires 31a and 31b disposed within respective secondary lumens in the wall of guide catheter 14. Rotation of knob 214 adjusts a degree of tension of wires 31a and 31b which, in turn, apply a force to pull ring 13 at the distal end portion of guide catheter 14. Such force steers the distal end portion of catheter 14 in a second plane within the atrium of the heart of the patient downward and toward the annulus of the cardiac valve. As described hereinbelow, the distal end portion of guide catheter 14 can be steered in the second plane that is substantially perpendicular with respect to the first plane in which the distal end portion of outer catheter 12 is steered.

0306The combined steering of the respective distal end portions of catheters 12 and 14 directs sleeve 26 down toward the annulus (e.g., via the steering of the distal end portion of catheter 14) and along the perimeter of annulus (e.g., from the posterior section of the valve to the anterior section of the valve, and vice versa), via the steering of the distal end portion of catheter 12.

0307For some applications, handle 22 can be tilted by the user (e.g., an operating physician, etc.), in order to further adjust a position of the distal end of catheter 12.

0308For some applications, handle 22 comprises an indicator that indicates a degree of steering (e.g., bending) of the distal end portion of catheter 12 that has been produced using knob 210. For some applications, handle 24 comprises an indicator that indicates a degree of steering (e.g., bending) of the distal end portion of catheter 12 that has been produced using knob 214.

0309As described herein, first and second couplings 152 and 154 of outer catheter 12 and guide catheter 14, respectively (e.g., slit 52 and engager 54, respectively), provide a controlled steerable system in which, during the steering and bending of the distal end portion of guide catheter 14, the distal end portion of outer catheter 12 is maintained in its steered configuration, or in its spatial orientation, without substantially affecting the steering or the bending of the distal end portion of guide catheter 14. Thus, first and second couplings 152 and 154, respectively, minimize the effect of the distal end portion of outer catheter 12 on the steering and bending of catheter 14. That is, first and second couplings 152 and 154 of outer catheter 12 and guide catheter 14, respectively, collectively define a relative-spatial-orientation-controlling device which rotationally locks the relative spatial orientation of the steerable distal end portion and the bending section of outer catheter 12 with respect to the steerable distal end portion and the bending section of guide catheter 14.

0310Contracting member 226 exits from the lumen in the wall of guide catheter 14 at a portion of handle portion 101 that is between handles 22 and 24.

0311Handle 126 can be coupled to track 90 via a second mount 93. Mount 93 can be slidable proximally and distally along a track, in order to control an axial position of reference-force tube 19 and at least a proximal portion of sleeve 26 with respect to guide catheter 14. Mount 93 can be slidable via a control knob. For example, the control knob of mount 93 can control the proximal and distal axial movement of the tube 19 and at least the proximal portion of sleeve 26 with respect to distal end 104 of guide catheter 14. Taken together with the steering of the distal end portion of guide catheter 14, such movement of tube 19 and at least the proximal portion sleeve 26 moves the proximal portion of sleeve 26 toward a desired portion of tissue of the annulus of the valve during deployment of anchors 32 from within the lumen of sleeve 26, as is described hereinbelow.

0312As is described hereinabove, in order to decouple sleeve 26 from a portion of an outer surface of channel 18, (1) channel 18 can be pulled proximally, while (2) reference-force tube 19 is maintained in place. A proximal end of channel 18 can be coupled to a knob 94 which adjusts an axial position of channel 18 proximally and distally with respect to reference-force tube 19 and sleeve 26.

0313Handle portion 101 can comprise a release-decision-facilitation member 127, such as a latch or button, that automatically engages when a given length of sleeve 26 has advanced off channel 18 (e.g., when channel 18 is at a given position with respect to tube 19); often just before sleeve 26 becomes completely decoupled from channel 18. Engagement of member 127 inhibits proximal movement of channel 18 with respect to tube 19, thereby reducing a likelihood of (e.g., preventing) inadvertent release of sleeve 26. In order to release sleeve 26 (e.g., to decouple channel 18 from the sleeve), the user (e.g., an operating physician) must disengage member 127, such as by pushing the button, before continuing to withdraw channel 18 proximally. When engaged, member 127 can also inhibit distal movement of channel 18 with respect to tube 19.

0314Handle portion 101 (comprising handles 22, 24, and 126 and anchor-release mechanism 28) can have a length L1 of between 65 and 85 cm, e.g., 76 cm. As shown, a majority of the body portion of outer-catheter handle 22 can be disposed at a non-zero angle with respect to a longitudinal axis 7 of the multiple components of system 10. The steering mechanism provided by handle 22 in order to steer the distal end portion of catheter 12 is disposed within the portion of handle 22 that is disposed at the non-zero angle with respect to axis 7. Handle 22 comprises an in-line tubular portion 21 which is longitudinally disposed in-line along axis 7 and coaxially with respect to handles 24 and 126 and release mechanism 28. Tubular portion 21 is shaped so as to define a lumen for inserting guide catheter 14 therethrough and subsequently into the lumen of outer catheter 12. Tubular portion 21 has a length L24 of between 7 and 11 cm, e.g., 7 cm. Such spatial orientation of the majority of handle 22 at an angle with respect to axis 7 reduces an overall functional length of handle portion 101.

0315Reference is now made to <figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref>, which are schematic illustrations of an example of a procedure for implanting an annuloplasty structure 222 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) to repair a mitral valve 230. This procedure is one example of a procedure that can be performed using system 10.

0316Annuloplasty structure or annuloplasty ring structure 222 can be used to repair a dilated valve annulus of an atrioventricular valve, such as mitral valve 230. For some applications, the annuloplasty structure is configured to be placed only partially around the valve annulus (e.g., to assume a C-shape), and, once anchored or otherwise secured in place, to be contracted so as to circumferentially tighten the valve annulus. For some applications, the annuloplasty structure is configured to be placed fully around the valve annulus (e.g., to assume a closed shape, such as a circle, oval, D-shape, etc.), and, once secured in place, to be contracted so as to circumferentially tighten the valve annulus. The annuloplasty structure can comprise a flexible sleeve 26. The annuloplasty structure can also comprise and/or be used with an attachment means (e.g., anchor(s), fastener(s), clamp(s), suture(s), clip(s), etc.), such as a plurality of anchors 32. Anchor deployment manipulator 61 is advanced into a lumen of sleeve 26, and, from within the lumen, deploys the anchors through a wall of the sleeve and into cardiac tissue, thereby anchoring the sleeve around a portion of the valve annulus. For some applications, annuloplasty structure or annuloplasty ring structure 222 is implemented using techniques described in <patcit id="pcit0003" dnum="US12437103B"><text>US Application No. 12/437,103, filed May 7, 2009</text></patcit> which issued as <patcit id="pcit0004" dnum="US8715342B"><text>US 8,715,342</text></patcit>, and/or <patcit id="pcit0005" dnum="US12689635B"><text>US Application No. 12/689,635, filed January 19, 2010</text></patcit> which issued as <patcit id="pcit0006" dnum="US8545553B"><text>US 8,545,553</text></patcit>, both of which are assigned to the assignee of the present application and are incorporated herein by reference.

0317As shown in <figref idref="f0003">Fig. 3A</figref>, the procedure can begin by advancing a semi-rigid guidewire 202 into a right atrium 220 of the patient. The procedure can be performed with the aid of imaging, such as fluoroscopy, transesophageal echo, and/or echocardiography.

0318As show in <figref idref="f0003">Fig. 3B</figref>, guidewire 202 provides a guide for the subsequent advancement of outer catheter 12 therealong and into the right atrium. Once a distal portion of catheter 12 has entered the right atrium, guidewire 202 is retracted from the patient's body. Catheter 12 can comprise a 14-24 F sheath, although any size may be selected as appropriate for a given patient. Catheter 12 is advanced through vasculature into the right atrium using a suitable point of origin determined for a given patient. For example: <ul id="ul0003" list-style="bullet"><li>catheter 12 can be introduced into the femoral vein of the patient, through an inferior vena cava 223, into right atrium 220, and into a left atrium 224 transseptally, for example, through the fossa ovalis;</li><li>catheter 12 can be introduced into the basilic vein, through the subclavian vein to the superior vena cava, into right atrium 220, and into left atrium 224 transseptally, for example, through the fossa ovalis; or</li><li>catheter 12 can be introduced into the external jugular vein, through the subclavian vein to the superior vena cava, into right atrium 220, and into left atrium 224 transseptally, for example, through the fossa ovalis.</li></ul>

0319For some applications, catheter 12 is advanced through inferior vena cava 223 of the patient (as shown) and into right atrium 220 using a suitable point of origin for a given patient.

0320Catheter 12 can be advanced distally until the sheath reaches the interatrial septum, and guidewire 202 is withdrawn, as shown in <figref idref="f0004">Fig. 3C</figref>.

0321As shown in <figref idref="f0004">Fig. 3D</figref>, a resilient needle 206 and a dilator (not shown) are advanced through catheter 12 and into the heart. In order to advance catheter 12 transseptally into left atrium 224, the dilator is advanced to the septum, and needle 206 is pushed from within the dilator and is allowed to puncture the septum to create an opening that facilitates passage of the dilator and subsequently catheter 12 therethrough and into left atrium 224. The dilator is passed through the hole in the septum created by the needle. The dilator can be shaped to define a hollow shaft for passage along needle 206, and the hollow shaft is shaped to define a tapered distal end. This tapered distal end is first advanced through the hole created by needle 206. The hole is enlarged when the gradually increasing diameter of the distal end of the dilator is pushed through the hole in the septum. For some applications, a distal end 102 of catheter 12 is tapered so as to facilitate passage of the distal portion of catheter 12 through the opening in the septum.

0322The advancement of catheter 12 through the septum and into the left atrium can be followed by the extraction of the dilator and needle 206 from within catheter 12, as shown in <figref idref="f0005">Fig. 3E</figref>. Once the distal portion of catheter 12 is disposed within atrium 224, the steerable distal end portion of catheter 12 (e.g., a bending section 1203 of catheter 12) can be steered in a first plane that is parallel to a plane of the annulus of mitral valve 230. Such steering moves the distal end portion of catheter 12 in a direction from the interatrial septum toward surrounding walls of the atrium, as indicated by the arrow in atrium 224. As described hereinabove, steering of the distal portion of catheter 12 can be performed via steering knob 210 of handle 22 in handle portion 101 (in <figref idref="f0001">Figs. 1</figref> and <figref idref="f0002">2</figref>).

0323As shown in <figref idref="f0005">Fig. 3F</figref>, annuloplasty structure or annuloplasty ring structure 222 (not shown for clarity of illustration, with anchor deployment manipulator 61 therein) is advanced through guide catheter 14, which is in turn, advanced through catheter 12 into left atrium 224. As shown in <figref idref="f0005">Fig. 3F</figref>, an exposed distal end portion 114 (e.g., a bending section 1403) of catheter 14 extends beyond distal end 102 of catheter 12. Exposed distal end portion 114 is then (1) steered toward the annulus of valve 230 along a plane that is perpendicular with respect to the steering plane of catheter 12 and that is perpendicular with respect to valve 230, and is (2) bent, via bending section 1403 toward valve 230. As described hereinabove, steering of the distal portion of catheter 14 is performed via steering knob 214 of handle 24 in handle portion 101 (in <figref idref="f0001">Figs. 1</figref> and <figref idref="f0002">2</figref>).

0324As shown in <figref idref="f0006">Fig. 3G</figref>, a distal end 251 of sleeve 26 is positioned in a vicinity of a left fibrous trigone 242 of an annulus 240 of mitral valve 230. (It is noted that for clarity of illustration, distal end 251 of sleeve 26 is shown schematically in the cross-sectional view of the heart, although left trigone 242 is in reality not located in the shown cross-sectional plane, but rather out of the page closer to the viewer.) Alternatively, the distal end of sleeve 26 is positioned in a vicinity of a right fibrous trigone 244 of the mitral valve (configuration not shown). Further alternatively, the distal end of the sleeve is not positioned in the vicinity of either of the trigones, but is instead positioned elsewhere in a vicinity of the mitral valve, such as in a vicinity of the anterior or posterior commissure. Once positioned at the desired site near the selected trigone, deployment manipulator 61 deploys a first anchor 32 through the wall of sleeve 26 (by penetrating the wall of the sleeve in a direction in a direction parallel to a central longitudinal axis of deployment manipulator 61, or anchor driver 36, through the distal end of channel 18, and/or parallel to central longitudinal axis of tissue-engaging element 60 of anchor 32) into cardiac tissue near the trigone. Following the deployment of anchor 32 in the cardiac tissue, deployment element 38 is decoupled from anchor 32 by moving rod 130 proximally.

0325Anchors 32 can be deployed from a distal end of manipulator 61 while the distal end is positioned such that a central longitudinal axis through the distal end of manipulator 61 forms an angle with a surface of the cardiac tissue of between about 20 and 90 degrees, e.g., between 45 and 90 degrees, such as between about 75 and 90 degrees, such as about 90 degrees. Anchors 32 can be deployed from the distal end of manipulator 61 into the cardiac tissue in a direction parallel to the central longitudinal axis through the distal end of manipulator 61. Such an angle can be provided and/or maintained by channel 18 being more rigid than sleeve 26. Distal end 17 (shown in <figref idref="f0002">Fig. 2</figref>) of channel 18 can be brought close to the surface of the cardiac tissue (and the wall of sleeve 26 that is disposed against the surface of the cardiac tissue), such that little of each anchor 32 is exposed from channel 18 before penetrating the sleeve and the tissue. For example, distal end 17 of channel 18 can be placed (e.g., pushed) against the wall of the sleeve, sandwiching the sleeve against the cardiac tissue.

0326For some applications, this placement of distal end 17 of channel 18 against the cardiac tissue (via the wall of the sleeve), stabilizes the distal end during deployment and anchoring of each anchor 32, and thereby facilitates anchoring. For some applications, pushing of distal end 17 against the cardiac tissue (via the wall of the sleeve) temporarily deforms the cardiac tissue at the site of contact. This deformation can facilitate identification of the site of contact using imaging techniques (e.g., by identifying a deformation in the border between cardiac tissue and blood), and thereby can facilitate correct positioning of the anchor.

0327For some applications, anchors 32 can be deployed from a lateral portion of manipulator 61.

0328Reference is now made to <figref idref="f0006">Figs. 3G</figref> and <figref idref="f0002">2</figref>. Following the deployment of the first anchor, a distal portion of sleeve 26 can be decoupled from a portion of implant-decoupling channel 18. In order to decouple the portion of sleeve 26 from outer surface of channel 18, (1) channel 18 can be pulled proximally, while (2) reference-force tube 19 is maintained in place in a manner in which a distal end of tube 19 provides a reference force to sleeve 26 in order to facilitate retraction freeing of a successive portion of sleeve 26 from around channel 18. In order to decouple sleeve 26 from the outer surface of channel 18, (1) channel 18 can be pulled proximally, while (2) reference-force tube 19 is maintained in place. An indicator (such as indicator 2120 described in PCT patent application <patcit id="pcit0007" dnum="IL2012050451W"><text>PCT/IL2012/050451 to Sheps et al.</text></patcit>, which published as <patcit id="pcit0008" dnum="WO2013069019A"><text>WO/2013/069019</text></patcit>, which is incorporated herein by reference) on handle 126 provides an indication of how much channel 18 is withdrawn from within sleeve 26 (i.e., how much the delivery tool is decoupled from sleeve 26, and how much the sleeve has advanced off channel 18 and against tissue). A proximal end of channel 18 is coupled to a knob 94 (<figref idref="f0002">Fig. 2</figref>) which adjusts an axial position of channel 18 proximally and distally with respect to reference-force tube 19 and sleeve 26. As shown in <figref idref="f0007">Fig. 3H</figref>, deployment manipulator 61 is repositioned along annulus 240 to another site selected for deployment of a second anchor 32. Reference is now made to <figref idref="f0001">Figs. 1</figref> and <figref idref="f0007">3H</figref>. Such repositioning of manipulator 61 is accomplished by: <ol id="ol0004"><li>(1) the steering of the distal end portion of catheter 12 (e.g., by steering knob 210 of handle 22) in the first plane that is parallel with respect to annulus 240 of valve 230 to a desired spatial orientation and in a manner which bends a bending section 1203 of catheter 12,</li><li>(2) the steering of the distal end portion of portion of catheter 14 (e.g., by steering knob 214 of handle 24) in the second plane that is perpendicular with respect to annulus 240 of valve 230 to a desired spatial orientation, and in a manner which bends bending section 1405 of catheter 14 (specifically bending section 1403),</li><li>(3) by axially moving catheter 14 with respect to catheter 12 via knob 216,</li><li>(4) by axially moving the stand supporting handles 22 and 24 to move both catheters 12 and 14,</li><li>(5) by moving tube 19 and sleeve 26 axially by sliding mount 93 along track 90 via knob 95, and/or</li><li>(6) by moving channel 18 relative to tube 19 by actuating knob 94.</li></ol>

0329Often, the first anchor is deployed most distally in the sleeve (generally at or within a few millimeters of the distal tip of the sleeve), and each subsequent anchor is deployed more proximally, such that the sleeve is gradually decoupled from channel 18 of deployment manipulator 61 in a distal direction during the anchoring procedure (i.e., channel 18 is withdrawn from within sleeve 26, and handle 126 is moved distally so as to retract the tool to make the successive proximal portion sleeve 26 ready for implantation of a subsequent anchor). The already-deployed first anchor 32 holds the anchored end of sleeve 26 in place, so that the sleeve is drawn from the site of the first anchor towards the site of the second anchor. As sleeve 26 is decoupled from channel 18, deployment manipulator 61 can be moved generally laterally along the cardiac tissue, as shown in <figref idref="f0007">Fig. 3H</figref>. Deployment manipulator 61 deploys the second anchor through the wall of sleeve 26 into cardiac tissue at the second site. Depending on the tension applied between the first and second anchor sites, the portion of sleeve 26 therebetween can remain tubular in shape, or can become flattened, which may help reduce any interference of the ring with blood flow.

0330As shown in <figref idref="f0008">Fig. 3I</figref>, deployment manipulator 61 can be repositioned along the annulus to additional sites, at which respective anchors are deployed, until the last anchor is deployed in a vicinity of right fibrous trigone 244 (or left fibrous trigone 242 if the anchoring began at the right trigone). Optionally, the last anchor is not deployed in the vicinity of a trigone, but is instead deployed elsewhere in a vicinity of the mitral valve, such as in a vicinity of the anterior or posterior commissure. Then, system 10 is removed, leaving behind implant structure 222 and contracting member 226. As is described hereinbelow, a contracting-member-uptake tool is then threaded over and advanced along contracting member 226 and toward structure 222, and is used to contract structure 222 by adjusting a degree of tension of contracting member 226 (not shown in <figref idref="f0008">Fig. 3I</figref>, but (i) advancing of contracting-member-uptake tool over contracting member 226 is described with reference to <figref idref="f0009 f0010 f0011 f0012">Figs. 4A-5D</figref>, mutatis mutandis, and (ii) applying tension to member 226 is described hereinbelow with reference to <figref idref="f0013 f0014">Figs. 6A-B</figref>).

0331Once the desired level of adjustment of structure 222 is achieved (e.g., by monitoring the extent of regurgitation of the valve under echocardiographic and/or fluoroscopic guidance), the contracting-member-uptake tool (1) locks contracting member 226 so as to maintain a degree of tension of member 226 in order to maintain structure 222 in a contracted state, and (2) severs any excess portion of contracting member 226 which is then removed from the heart. For some applications, a distal portion of guide member 86 may be left within the heart of the patient and the proximal end can be accessible outside the body, e.g., using a port. For such applications, adjusting mechanism 40 can be accessed at a later stage following initial implantation and adjustment of ring structure 222.

0332For some applications, a re-access wire 288 can be provided, coupled to a proximal portion of the implant (e.g., a portion of the implant that is deployed last), such as to a last anchor 32 (as shown in <figref idref="f0008">Fig. 3I</figref>) or sleeve 26, such that, upon anchoring, the wire extends proximally, e.g., out of the body of the subject, such as via catheter 14 and/or catheter 12. Should it be determined, after implantation (e.g., and after adjustment) of annuloplasty structure 222, that one or more anchors 32 require adjustment or retrieval, re-access wire 288 facilitates guidance of an anchor-manipulation tool to annuloplasty structure 222 and/or into the lumen thereof. For example, such an anchor-manipulation tool can comprise an anchor-manipulation tool described in a PCT patent application <patcit id="pcit0009" dnum="IL2013050861W"><text>PCT/IL2013/050861 to Herman et al, titled "Percutaneous tissue anchor techniques", filed on October 23, 2013</text></patcit>, and incorporated herein by reference. Systems, apparatuses, and techniques described in the present patent application can be used in combination with systems, apparatuses, and techniques described in said PCT patent application <patcit id="pcit0010" dnum="IL2013050861W"><text>PCT/IL2013/050861</text></patcit>.

0333As shown, sleeve 26 of ring structure 222 comprises a plurality of radiopaque markers 25, which are positioned along the sleeve at respective longitudinal sites to indicate anchor-designated target areas. The markers can provide an indication in a radiographic image (such as a fluoroscopy image) of how much of sleeve 26 has been deployed at any given point during an implantation procedure, in order to enable setting a desired distance between anchors 32 along the sleeve 26.

0334For some applications, and as shown in <figref idref="f0008">Fig. 3I</figref>, anchors 32 are deployed at longitudinal sites of sleeve 26 at which radiopaque markers 25 are disposed (e.g., the anchors are driven through a radiopaque ink of the radiopaque markers). Alternatively, anchors 32 can be deployed at longitudinal sites of sleeve 26 between markers 25. For example, when dispensing sleeve 26 from channel 18 (i.e., when advancing sleeve 26 with respect to channel 18 and/or withdrawing channel 18 from sleeve 26), the appearance of a marker 25 at the distal end of channel 18 (e.g., the marker 25 becoming aligned with marker 1018 of channel 18) can indicate that a correct length of sleeve 26 has been dispensed. Subsequent limited movement of the channel with respect to the sleeve may occur. For example, when channel 18 is placed against the annulus, the channel may tension the portion of sleeve 26 between the previously-deployed anchor and the distal end of the channel, such that when the anchor is deployed, it passes through the sleeve slightly proximally to the marker 25 (e.g., 1-2 mm proximally to the marker).

0335Alternatively, annuloplasty structure 222 is implanted by right or left thoracotomy, mutatis mutandis.

0336For some applications, following implantation of sleeve 26 along the annulus, an excess portion of sleeve 26 may be present at the proximal portion of sleeve. In such applications, following removal of manipulator 61, a cutting tool (not shown) can be advanced within channel 18 and into the lumen of the excess portions of sleeve 26 (e.g., from within sleeve 26) in order to cut the sleeve proximal to the proximal-most-deployed anchor 32.

0337Reference is now made to <figref idref="f0009 f0010">Figs. 4A-B</figref>, which are schematic illustrations of an example system 10 comprising an example contracting-member-uptake tool 300 which is configured to contract contracting member 226 and sever any excess portions of contracting member 226. Tool 300 comprises a handle portion 320 and an elongate sheath 310 coupled thereto. Sheath 310 encases a primary tube 330 and a secondary tube 340 disposed alongside primary tube 330. Both primary tube 330 and secondary tube 340 are coupled to handle portion 320 at respective proximal ends of tubes 330 and 340. Secondary tube 340 has a secondary-tube-lumen configured for passage therethrough of contracting member 226. Tool 300 defines a longitudinal axis 301.

0338For some applications, sheath 310 is shaped so as to define a lumen in a wall of sheath 310. For such applications, tool 300 does not comprise secondary tube 340, but rather, the lumen in the wall of sheath 310 functions as secondary tube 340 and the primary lumen defined by the wall of sheath 310 functions as primary tube 330.

0339Sheath 310, primary tube 330, and secondary tube 340 can be flexible such that sheath 310, primary tube 330, and secondary tube 340 are configured for passage through vasculature of the patient during a transvascular, transcatheter procedure. However, similar features can be used for surgical procedures. For some applications, sheath 310, primary tube 330, and secondary tube 340 comprise silicone. For some applications, sheath 310, primary tube 330, and secondary tube 340 comprise polyurethane.

0340Tool 300 can comprise a contracting-member-snare 350 comprising a distal snare portion 352 and an elongate flexible body portion 354 coupled to distal snare portion 352. Distal snare portion 352 is configured to ensnare a portion of contracting member 226 as will be described hereinbelow and is sized to pass through the secondary-tube lumen of secondary tube 340 in order to pull contracting member 226 through a length of secondary tube 340.

0341Distal snare portion 352 can define a looped portion, as shown. For some applications, distal snare portion 352 is shaped so as to define a hook.

0342Tool 300 can comprise a distal end portion 333 having a distal tip 331 which defines a distal end of tool 300. Primary tube 330 terminates at distal end portion 333. Distal end portion 333 comprises a housing 332 which is shaped so as to hold and be removably coupled to a contracting-member-fastener 360. Contracting-member-fastener 360 comprises a clamping structure that can be biased toward assuming a closed state or closed position, and in the closed state/position, the clamping structure can be configured to clamp onto the contracting member 226 passed therethrough (not shown). The clamping structure can also be configured such that it can be flexed to an open state through which contracting member 226 (not shown) can move.

0343Tool 300 can comprise a fastener-ejector 335 movable within distal end portion 333 of contracting-member-uptake tool 300. Movement of fastener-ejector 335 converts contracting-member-fastener 360 (or clamping structure thereof) from its open state to its closed state to clamp onto contracting member 226 passed therethrough, as will be described hereinbelow. Tool 300 comprises a stop 362 removably coupled to contracting-member-fastener 360 and configured to maintain contracting-member-fastener 360 in the open state, as shown in Section A-A of <figref idref="f0009">Fig. 4A</figref>. Stop 362 comprises one or more, e.g., two, prongs 337 which maintain fastener 360 in the open state. Ejector 335 is coupled to stop 362 and moves stop 362 that is removably coupled to fastener 360 in order to convert fastener 360 from the open state to a closed state, as is described hereinbelow.

0344<figref idref="f0010">Fig. 4B</figref> shows handle portion 320 of tool 300 with a casing removed in order to view the inside of handle portion 320. Handle portion 320 comprises a contracting-member-uptake device 322 configured to uptake successive portions of contracting member 226 (not shown), as is described hereinbelow. Contracting-member-uptake device 322 is actuatable to increase tension of the contracting member, as is described hereinbelow. Tension of contracting member 226 is measured by a tension meter 324 of handle portion 320.

0345Contracting-member-uptake device 322 can optionally comprise a wheel, which can have two opposing wedged portions 325 which together define a groove 326 configured to couple contracting member 226 to the wheel of device 322. Wedged portions 325 can be shaped so as to receive any portion of contracting member 226, e.g., a proximal end of member 226 and/or a middle portion of member 226. For some applications, opposing wedged portions 325 are configured to grip contracting member 226. As shown, the wheel of device 322 can have a numerical indicator to indicate the number of turns of the wheel.

0346As shown, handle portion 320 is coupled to respective proximal portions of primary tube 330 and secondary tube 340.

0347Handle portion 320 can be shaped so as to define a lumen 328 for passage therethrough of snare 350 from within the lumen of secondary tube 340. Snare 350 passes through lumen 328 and beyond groove 326 of contracting-member-uptake device 322. Often, but not necessarily, device 322 does not uptake snare 350 but rather, snare 350 passes through groove 326. As is described hereinbelow, pulling on snare 350 pulls on contracting member 226 coupled thereto such that contracting member 226 is pulled through secondary tube 340, through lumen 328 and ultimately toward contracting-member-uptake device 322. Once the proximal end of contracting member 226 (or a portion in a vicinity of the proximal end of member 226) is pulled through tube 340 and through lumen 328, contracting member 226 is coupled to contracting-member-uptake device 322 by being fed into groove 326. Contracting-member-uptake device 322 is then actuated in order to apply tension to contracting member 226, and thereby to annuloplasty structure 222 implanted along the annulus. With each rotation of the wheel of device 322, successive portions of contracting member 226 are wound within groove 326 of device 322.

0348<figref idref="f0011 f0012">Figs. 5A-D</figref> are schematic illustrations of an example contracting-member-uptake tool 300 useable to uptake contracting member 226. At this stage, annuloplasty structure or annuloplasty ring structure 222 has been implanted along annulus 240, as described hereinabove with reference to <figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref>. Once structure 222 has been implanted along the annulus, contracting member 226 extends away from structure 222 and through vasculature of the patient such that a proximal end portion of member 226 is disposed outside the body of the patient.

0349Contracting member 226 can exit sleeve 26 of structure 222 at any suitable location along structure 222. For example, contracting member 226 can exit sleeve 26 of structure 222 at a portion of structure 222 in a vicinity of a left fibrous trigone of the valve, as shown. For some applications, contracting member 226 exits sleeve 26 of structure 222 at a portion of structure 222 in a vicinity of a right fibrous trigone of the valve. For some applications, contracting member 226 exits sleeve 26 of structure 222 at a middle portion of structure 222.

0350As shown, structure 222 comprises sleeve 26 which defines the primary body portion of structure 222. Contracting member 226 has a first portion 420 extending along a longitudinal length of the primary body portion of annuloplasty structure 222. The first portion 420 can extend along the longitudinal length of structure 222 when structure 222 is in a linear state as well as in a curved state, as shown in <figref idref="f0011">Fig. 5A</figref>. Contracting member 226 also defines a second portion 422 extending away from the primary body portion of annuloplasty structure 222.

0351In <figref idref="f0011">Fig. 5A</figref>, the user (e.g., an operating physician, etc.) can hold a distal end of tool 300 in one hand and a proximal end portion of contracting member 226 in another hand. The user or physician threads the proximal end portion of contracting member 226 through distal snare portion 352 of contracting-member-snare 350.

0352<figref idref="f0012">Fig. 5B</figref> shows tool 300 in a state in which distal snare portion 352 ensnares contracting member 226. For some applications, distal snare portion 352 is shaped so as to increase the coupling between snare 350 and contracting member 226. For example, for some applications, distal snare portion 352 is corrugated to increase friction between snare portion 352 and contracting member 226. For some applications, distal snare portion 352 can comprise a coiled section to increase friction between snare portion 352 and contracting member 226. For some applications, snare 350 comprises a metal wire. For some applications, snare 350 comprises a metal wire comprising stainless steel. Snare 350 (including distal snare portion 352) can have a variety of sizes, for example, a diameter of 0.15-0.5 mm or 0.15-0.35 mm.

0353Reference is now made to <figref idref="f0009">Figs. 4A</figref> and <figref idref="f0012">5B</figref>. As shown in Section A-A of <figref idref="f0009">Fig. 4A</figref>, contracting-member-snare 350 passes through aligned ports 339 and 341 in distal end portion 333 of tool 300.

0354Snare 350 can be pulled proximally, e.g., by the user or physician holding the proximal exposed end portions 351 of snare 350 proximally away from tool 300. Pulling on snare 350 proximally, as shown in <figref idref="f0012">Fig. 5C</figref>, pulls distal snare portion 352 and contracting member 226 looped therethrough through distal tip 331 of tool 300, through the fastener disposed within distal end portion 333 of tool 300, through aligned ports 339 and 341 in distal end portion 333 of tool 300, and subsequently, through the lumen of secondary tube 340.

0355Snare 350 is pulled until distal snare portion 352 enters the lumen of secondary tube 340. As a result, the looped portion of distal snare portion 352 is compressed and collapses around contracting member 226 looped therethrough, in order to maintain coupling between snare portion 352 and contracting member 226 as elongate flexible body portion 354 (shown in <figref idref="f0012">Fig. 5B</figref>) is pulled through the lumen of secondary tube 340. As the looped portion of snare portion 352 collapses within the lumen of secondary tube 340, the portion of contracting member 226 ensnared by snare portion 352 bends, and coupling between contracting member 226 and snare portion 352 is strengthened. This strengthening is also brought about as a result of the relatively small diameter of secondary tube 340 of 0.5-1.0 mm.

0356In <figref idref="f0012">Fig. 5D</figref>, snare 350 is pulled entirely through secondary tube 340, through lumen 328 of handle portion 320 and beyond groove 326 of contracting-member-uptake device 322 in order to pull contracting member 226 along this path. All the while, sheath 310 of tool 300 is advanced through vasculature and toward annuloplasty structure 222 implanted along annulus 240 of the valve. Once distal snare portion 352 and the portion of contracting member 226 coupled thereto exit lumen 328 of handle portion 320, the portion of contracting member 226 is coupled to contracting-member-uptake device 322 by being positioned within groove 326. For some applications, the proximal end portion of contracting member 226 is fed within groove 326. For some applications, a middle portion of contracting member 226 (e.g., a portion in a vicinity of the proximal end of contracting member 226) is fed within groove 326. Contracting member 226 is then tightened by actuating, e.g., rotating, contracting-member-uptake device 322 such that successive portions of contracting member 226 are wound within contracting-member-uptake device 322 and contracting-member-uptake device 322 uptakes the successive portions.

0357Once snare 350 has been pulled through tool 300, snare 350 can be discarded.

0358Reference is now made to <figref idref="f0013 f0014">Figs. 6A-B</figref>, which are schematic illustrations of an example tool 300 used to pull on contracting member 226 in order to contract contracting member 226 and thereby annuloplasty structure or annuloplasty ring structure 222 coupled thereto. Contracting-member-uptake device 322 is rotated in order to facilitate the uptake of successive portions of contracting member 226.

0359As shown in <figref idref="f0013">Fig. 6A</figref>, prior to rotating contracting-member-uptake device 322, tension meter 324 of handle portion 320 reads a tension of contracting member 226 at zero or close to zero. Similarly, sleeve 26 of annuloplasty structure 222 coupled to annulus 240 is in a relaxed, non-tense state. At this point, tool 300 has been sufficiently advanced through vasculature of the patient such that distal tip 331 is in proximity to structure 222 disposed along the annulus, while a proximal portion of contracting member 226 is disposed outside the body of the patient.

0360In <figref idref="f0014">Fig. 6B</figref>, contracting-member-uptake device 322, is rotated to contract and apply tension to contracting member 226. Tension meter 324 of handle portion 320 reads a tension of contracting member 226 between 4 and 5. Similarly, sleeve 26 of annuloplasty structure 222 coupled to annulus 240 is in a tense, contracted state. As shown in <figref idref="f0014">Fig. 6B</figref>, contracting member 226 is in a tense state with respect to tool 300.

0361Reference is now made to <figref idref="f0015 f0016">Figs. 7A-E</figref>, which are schematic illustrations of an example tool 300 used to lock and secure annuloplasty structure 222 in its contracted state and subsequently, sever excess portions of contracting member 226.

0362<figref idref="f0015">Fig. 7A</figref> shows annuloplasty structure or annuloplasty ring structure 222 in a non-contracted state. Distal tip 331 of tool 300 can be brought close to structure 222. Contracting member 226 can be threaded along sleeve 26 and out of a portion of sleeve 26 of structure 222. As described hereinabove, contracting member 226 can be threaded through tool 300 in a manner in which member 226 passes through distal tip 331, through contracting-member-fastener 360 that can be held in the open state, such as by prongs 337 of stop 362, through aligned ports 339 and 341 in distal end portion 333 of tool 300, and through secondary tube 340.

0363As shown in <figref idref="f0015">Fig. 7B</figref>, once distal tip 331 of tool 300 contacts sleeve 26 of structure 222, tool 300 can be used to contract structure 222 by tool 300 pulling on contracting member 226. During contraction of structure 222, fastener 360 is not deployed.

0364In <figref idref="f0015">Fig. 7C</figref>, contracting member 226 has been pulled tight, and annuloplasty structure 222 has been contracted and in a tense, contracted state. Distal end portion 333 of tool 300 is then used to eject and deploy fastener 360 from within tool 300 in order to lock structure 222 in the contracted state.

0365Reference is now made to <figref idref="f0014">Figs. 6B</figref> and <figref idref="f0015">7C</figref>. Once distal tip 331 contacts sleeve 26, a trigger 321 (shown in <figref idref="f0014">Fig. 6B</figref>) at handle portion 320 of tool 300 is pulled partially, in order to facilitate ejecting and deploying of contracting-member-fastener 360 from within housing 332 of distal end portion 333. As described hereinabove, fastener-ejector 335 is movable within distal end portion 333 of contracting-member-uptake tool 300. Movement of fastener-ejector 335 converts contracting-member-fastener 360 from its open state to its closed state to clamp onto contracting member 226 passed therethrough. Fastener-ejector 335 is coupled to prongs 337 of stop 362 in a manner in which when ejector 335 is moved proximally within portion 333, stop 362 is decoupled from contracting-member-fastener 360 as prongs 337 move proximally away from contracting-member-fastener 360. Once contracting-member-fastener 360 is no longer held in the open state by stop 362, fastener 360 closes, as it tends to do, and clamps around contracting member 226 passing therethrough.

0366A proximal portion of fastener-ejector 335 can be coupled to a distal end of a movement tube 343 which can be coupled at a proximal end thereof to trigger 321. Movement tube 343 is movable proximally in response movement of trigger 321, and consequently, fastener-ejector 335 is moved proximally with respect to distal tip 331 of tool 300 and with respect to fastener 360. As shown in <figref idref="f0015">Fig. 7B</figref>, fastener 360 has been ejected and deployed from within housing 332 of ejector 335.

0367In <figref idref="f0016">Fig. 7D</figref>, fastener-ejector 335 can be moved further proximally in response to the further pulling of trigger 321, in order to sever excess portions of contracting member 226. Tool 300 can be shaped so as to define a cutting-facilitating edge 370 in distal end portion 333 of tool 300. For some applications, cutting-facilitating edge 370 defines a sharp edge. While contracting member 226 passes through aligned ports 339 and 341 in distal end portion 333 of tool 300, as shown in <figref idref="f0015">Figs. 7A-C</figref>, contracting member 226 is in proximity with cutting-facilitating edge 370. Movement of fastener-ejector 335 proximally brings a cutting-facilitating edge 372 of ejector 335 against cutting-facilitating edge 370 of tool 300, thus sandwiching a portion of contracting member 226 between edges 370 and 372, in order to sever and cut contracting member 226 extending through ports 339 and 341. For some applications, cutting-facilitating edge 372 defines a sharp edge. <figref idref="f0016">Fig. 7D</figref> shows contracting member 226 severed once cutting-facilitating edge 372 of ejector 335 has been brought against cutting-facilitating edge 370 of tool 300.

0368As shown in <figref idref="f0016">Fig. 7E</figref>, once contracting member 226 has been severed, tool 300 is withdrawn proximally, bringing together with it the excess portion of contracting member 226.

0369Reference is now made to <figref idref="f0017 f0018 f0019 f0020">Figs. 8A-D</figref>, which are schematic illustrations of an example of a system 510 for contracting annulus 240 of the patient using an annuloplasty structure 522 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.), which can comprise a housing 530. Housing 530 can house a contracting-member-fastener 360. Except for the differences described hereinbelow, annuloplasty structure 522 can be the same as or generally similar to annuloplasty structure 222, described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016">Figs. 1-7E</figref> and like reference numerals refer to like parts.

0370Annuloplasty structure or annuloplasty ring structure 522 can comprise sleeve 26 which can define a primary body portion of structure 522. Structure 522 comprises contracting member 226 having a first portion 526 extending along a longitudinal length of the primary body portion of annuloplasty structure 522. The first portion 526 can extend along the longitudinal length of structure 522 when structure 522 is in a linear state as well as in a curved state, as shown in <figref idref="f0017">Fig. 8A</figref>. Contracting member 226 also defines a second portion 524 extending away from the primary body portion of annuloplasty structure 522.

0371Contracting member 226 can extend through housing 530 and through a stop 570 (e.g., a holder) that is disposed within an opening of contracting-member-fastener 360. Stop 570 is shown as being cylindrical by way of illustration and not limitation. The outer surface of stop 570 maintains fastener 360 in the open state. Stop 570 is shaped so as to define a threaded portion 572 which enables coupling thereto of a contracting-member-uptake tool, as is described hereinbelow.

0372Annuloplasty structure or annuloplasty ring structure 522 is implanted as described hereinabove with reference to <figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref> using the system described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008">Figs. 1-3I</figref>.

0373Housing 530 can be coupled to sleeve 26 of structure 522 at any suitable location along structure 522. For example, housing 530 can be coupled to sleeve 26 of structure 522 at a portion of structure 522 in a vicinity of a left fibrous trigone of the valve, as shown. For some applications, housing 530 can be coupled to sleeve 26 of structure 522 at a portion of structure 522 in a vicinity of a right fibrous trigone of the valve. For some applications, housing 530 can be coupled to sleeve 26 of structure 522 at a middle portion of structure 522. As shown, housing 530 can be coupled to a lateral surface of sleeve 26. In such applications, housing 530 does not block them lumen of sleeve 26 of structure 522.

0374<figref idref="f0018">Fig. 8B</figref> shows a contracting-member-uptake tool 600 through which contracting member 226 has been threaded. Contracting member 226 can be ensnared by tool 600 using a snare as described herein above with regard to snare 350 with reference to <figref idref="f0009 f0010 f0011 f0012">Figs. 4A-5D</figref>. Tool 600 can be advanced along contracting member 226 toward housing 530 of structure 522, in a manner similar to tool 300 advancing along contracting member 226, as described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012">Figs. 4A-5D</figref>.

0375Tool 600 can comprise a distal tip 631 and a distal end portion 633 which is generally similar to distal end portion 533 of tool 300, described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016">Figs. 4A-7E</figref> and like reference numerals refer to like parts. Since annuloplasty structure 522 comprises contracting-member-fastener 360 and stop 570 removably coupled to fastener 360, distal end portion 633 of tool 600 is unlike distal end portion 533 of tool 300 of <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016">Figs. 4A-7E</figref>, remaining parts of tool 600 correspond to the remaining parts of tool 300.

0376Once tool 600 is threaded along contracting member 226, contracting member 226 extends from sleeve 26, through stop 570, through a stop-coupler 672 of tool 600, through distal tip 631, and then through aligned ports 339 and 341 of distal end portion 633 of tool 600.

0377Stop-coupler 672 of tool 600 screws into and engages threaded portion 572 of stop 570 coupled to contracting-member-fastener 360 disposed within housing 530 of structure 522.

0378As described hereinabove with reference to <figref idref="f0013 f0014">Figs. 6A-B</figref>, a contracting-member-uptake device of tool 600 (not shown, but similar to contracting-member-uptake device 322 of tool 300) can be used to contract contracting member 226. Once contracting member 226 is contracted and structure 522 is contracted, as shown in <figref idref="f0019">Fig. 8C</figref>, tool 600 removes stop 570 by pulling stop 570 proximally away from fastener 360. Since fastener 360 tends to close, in the absence of stop 570, fastener 360 closes and clamps around contracting member 226 passing through fastener 360. In such a manner, structure 522 is locked by fastener 360 and the contracted state of structure 522 is maintained.

0379<figref idref="f0020">Fig. 8D</figref> shows contracting member 226 being severed proximal to fastener 360 and excess portions of contracting member 226 being removed from the body of the patient using tool 600. Severing of contracting member 226 is performed in a manner as described hereinabove with reference to <figref idref="f0015 f0016">Figs. 7A-E</figref>, <i>mutatis mutandis.</i>

0380Reference is now made to <figref idref="f0021 f0022">Figs. 9A-D</figref>, which are schematic illustrations of an example contracting-member-uptake tool 600 used to lock and secure annuloplasty structure 522 of <figref idref="f0017 f0018 f0019 f0020">Figs. 8A-D</figref> in its contracted state and subsequently, sever excess portions of contracting member 226.

0381<figref idref="f0021">Fig. 9A</figref> shows annuloplasty structure 522 in a partially, contracted state. Contracting member 226 can be threaded along sleeve 26 and out of a portion of sleeve 26 of structure 222. As described hereinabove, contracting member 226 can be threaded through tool 600 in a manner in which member 226 passes through a stop-coupler 672 of tool 600, through distal tip 631, through aligned ports 339 and 341 in distal end portion 633 of tool 600, and through secondary tube 340.

0382In <figref idref="f0021">Fig. 9B</figref>, contracting member 226 has been pulled tight, and annuloplasty structure 522 has been contracted and in a tense, contracted state. Distal end portion 633 of tool 300 is brought closely to annuloplasty structure 522 (e.g., tip 631 contacts housing 530 or is brought close, as shown) in order to eject and deploy fastener 360 within housing 530 in order to lock structure 522 in the contracted state.

0383Once distal end portion 633 is brought into proximity with sleeve 26, trigger on the handle portion of tool 600 (similar to trigger 321 of tool 300 as shown in <figref idref="f0014">Fig. 6B</figref>) can be pulled partially, in order to facilitate ejecting and deploying of contracting-member-fastener 360 distally within housing 530 of annuloplasty structure 522. Fastener-ejector 335 is movable within distal end portion 633 of contracting-member-uptake tool 600. Movement of fastener-ejector 335 converts contracting-member-fastener 360 (e.g., a clamping structure thereof) from its open state to its closed state to clamp onto contracting member 226 passed therethrough. Fastener-ejector 335 is coupled to stop-coupler 672 of tool 600 which screws into and engages threaded portion 572 of stop 570 in a manner in which when ejector 335 is moved proximally within portion 633 of tool 600, stop 570 is pulled away from fastener 630 and decoupled therefrom. Once contracting-member-fastener 360 is no longer held in the open state by stop 570, fastener 360 closes, as it tends to do, and clamps around contracting member 226 passing therethrough.

0384In <figref idref="f0022">Fig. 9C</figref>, fastener-ejector 335 can be moved further proximally (in response to the further pulling of the trigger of the handle portion of tool 600), in order to sever excess portions of contracting member 226. Tool 600 can be shaped so as to define a cutting-facilitating edge 370 in distal end portion 633 of tool 600. For some applications, cutting-facilitating edge 370 defines a sharp edge. While contracting member 226 passes through aligned ports 339 and 341 in distal end portion 633 of tool 600, as shown in <figref idref="f0021">Fig. 9B</figref>, contracting member 226 is in proximity with cutting-facilitating edge 370. Movement of fastener-ejector 335 proximally brings a cutting-facilitating edge 372 of ejector 335 against cutting-facilitating edge 370 of tool 300, thus sandwiching a portion of contracting member 226 between edges 370 and 372, in order to sever and cut contracting member 226 extending through ports 339 and 341. For some applications, cutting-facilitating edge 372 defines a sharp edge. <figref idref="f0022">Fig. 9C</figref> shows contracting member 226 severed once cutting-facilitating edge 372 of ejector 335 has been brought against cutting-facilitating edge 370 of tool 600.

0385As shown in <figref idref="f0022">Fig. 9D</figref>, once contracting member 226 has been severed, tool 600 is withdrawn proximally, bringing together with it the excess portion of contracting member 226.

0386Reference is now made to <figref idref="f0017 f0018 f0019 f0020 f0021 f0022">Figs. 8A-9D</figref>. System 510 provides an annuloplasty structure 522 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) in which housing 530 houses contracting-member-fastener 360, rather than fastener 360 being disposed outside sleeve 26. In such a manner, system 510 reduces the possibility of embolism and/or clotting.

0387Reference is now made to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022">Figs. 4A-9D</figref>. Contracting-member-uptake tools 300 and 600 can be used to (1) apply tension to the contracting member, (2) deploy a lock in order to secure tension of the contracting member, and (3) subsequently cut and sever the contracting member of any annuloplasty structure, e.g., a full annuloplasty ring structure, a partial annuloplasty ring structure, etc.

0388Reference is again made to <figref idref="f0017 f0018 f0019 f0020">Figs. 8A-D</figref> and <figref idref="f0021 f0022">9A-D</figref>. It is to be noted that although tool 600 is described as being advanceable toward housing 530 that is already coupled to annuloplasty structure 522, the scope herein includes tool 600 being coupled to housing 530 from a site outside the body of the patient and being configured to deliver housing 530 along contracting member 226 to sleeve 26 of structure 522 that is already implanted at the annulus. For such applications, housing 530 is configured to be positionable against the primary body portion of structure 522.

0389Reference is now made to <figref idref="f0023">Figs. 10A-B</figref>, which are schematic illustrations of an example system 700 comprising an example contracting-member-uptake tool 702 which is configured to contract contracting member 226 and sever any excess portions of contracting member 226.

0390Except for the differences described hereinbelow, contracting-member-uptake tool 702 can be the same as or generally similar to contracting-member-uptake tools 300 and 600, described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022">Figs. 4A-9D</figref>, used to (1) apply tension to the contracting member, (2) deploy a lock in order to secure tension of the contracting member, and (3) subsequently cut and sever the contracting member of any annuloplasty structure, e.g., a full (or closed) annuloplasty ring structure or a partial (or open) annuloplasty ring structure.

0391Example contracting-member-uptake tool 702 is useable to uptake contracting member 226 of an annuloplasty structure 730. Annuloplasty structure 730 can be the same as or generally similar to annuloplasty structures 222 or 522, described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022">Figs. 1-9D</figref> and like reference numerals refer to like parts. At this stage, annuloplasty structure 730 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) has been implanted along the annulus, as described hereinabove with reference to <figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref>. Once structure 730 has been implanted along the annulus, contracting member 226 extends away from structure 730 and through vasculature of the patient such that a proximal end portion of member 226 is disposed outside the body of the patient.

0392Except for the differences described hereinbelow, annuloplasty structure 730 can be the same as or generally similar to annuloplasty structures 222 and 522, described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022">Figs. 1-9D</figref> and like reference numerals refer to like parts. Annuloplasty structure 730 can be a full (or closed) or partial (or opened) annuloplasty structure.

0393As shown, structure 730 comprises sleeve 26 which defines the primary body portion of structure 730. Contracting member 226 has a first portion 732 extending along a longitudinal length of the primary body portion of annuloplasty structure 730. Contracting member 226 also defines a second portion 734 extending away from the primary body portion of annuloplasty structure 730.

0394Although tool 702 is used to implant a full (or closed) annuloplasty structure 730, as shown, the annuloplasty structure can be an annuloplasty ring structure and can comprise a partial (or open) annuloplasty structure.

0395For some applications, annuloplasty structure 730 is implemented using techniques described in <patcit id="pcit0011" dnum="US12341960B"><text>US Application No. 12/341,960, filed December 22, 2008</text></patcit>, which issued as <patcit id="pcit0012" dnum="US8241351B"><text>US 8,241,351</text></patcit>, <patcit id="pcit0013" dnum="US12437103B"><text>US Application No. 12/437,103, filed May 7, 2009</text></patcit> which issued as <patcit id="pcit0014" dnum="US8715342B"><text>US 8,715,342</text></patcit>, and/or <patcit id="pcit0015" dnum="US12689635B"><text>US Application No. 12/689,635, filed January 19, 2010</text></patcit> which published as <patcit id="pcit0016" dnum="US8545553B"><text>US 8,545,553</text></patcit>, both of which are assigned to the assignee of the present application and are incorporated herein by reference.

0396Tool 702 can be configured in various ways. In some applications, tool 702 comprises an elongate sheath 310. In some applications, sheath 310 encases a primary tube 330 and a secondary tube 340 disposed alongside primary tube 330. For such applications, sheath 310 is shaped to as to define secondary tube 340. Secondary tube 340 is shaped so as to define a longitudinal slit 740. Slit 740 facilitates ease of coupling and engagement of contracting member 226 within the lumen of tube 340. Slit 740 also enables ease of release of contracting member 226 from within the lumen of tube 340. For some applications, slit 740 facilitates ease of coupling and/or release of the contracting-member-snare as described hereinabove with reference to <figref idref="f0009 f0010">Figs. 4A-B</figref>. For some applications, a distal-most section of slit 740 is at a longitudinal position along tube 340 that is proximal to a distal-most end of tube 340, e.g., a part of tube 340 that is configured to be disposed proximally to a ventricle of the heart of the patient, such that leaking of blood from within the heart through slit 740 is prevented.

0397Tool 702 is used to deploy one or more (e.g., two as shown) contracting-member-fasteners 360a and 360b. Fasteners 360a and 360b are similar to or the same as fasteners 360 described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022">Figs. 4A-9D</figref>. The use of two fasteners 360a and 360b can provide redundant and more secure fastening of a perimeter of structure 730 following contraction thereof. Fasteners 360a and 360b can be disposed coaxially around a portion of contracting member 226

0398For some applications, a pushing tube (not shown) is used to deploy contracting-member-fasteners 360a and 360b. The pushing tube comprises a semi-rigid material used to deploy by pushing fasteners 360a and 360b. Fasteners 360a and 360b can be disposed coaxially around a portion of contracting member 226 and distally to a distal end of the pushing tube. For some applications, fasteners 360a and 360b are removably disposed around a portion of the pushing tube.

0399Following the deployment of fasteners 360a and 360b, tool 702 is used to sever any excess portions of contracting member 226, as described hereinbelow with reference to tools 300 and 600 as described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022">Figs. 4A-9D</figref>.

0400For some applications, oversheath 710 is not used and tool 702 is coupled to the annuloplasty structure using male and female couplings, as shown hereinbelow with reference to <figref idref="f0025">Figs. 12</figref>, <figref idref="f0026">13</figref>, and <figref idref="f0028">15</figref>.

0401Reference is now made to <figref idref="f0024">Figs. 11A-C</figref>, which are schematic illustrations of an example system 800 comprising an example contracting-member-uptake tool 810 used to lock and secure annuloplasty structure 222 in its contracted state and subsequently, sever excess portions of contracting member 226, in accordance with some applications.

0402Except for the differences described hereinbelow, contracting-member-uptake tool 810 can be the same as or generally similar to contracting-member-uptake tools 300 and 600, described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022">Figs. 4A-9D</figref>, used to (1) apply tension to the contracting member, (2) deploy a lock in order to secure tension of the contracting member, and (3) subsequently cut and sever the contracting member of any annuloplasty structure, e.g., a full (or closed) annuloplasty ring structure, a partial (or open) annuloplasty structure, etc.

0403<figref idref="f0024">Fig. 11A</figref> shows annuloplasty structure or annuloplasty ring structure 222 in a non-contracted state. Distal tip 331 of tool 810 can be brought close to structure 222. Contracting member 226 can be threaded along sleeve 26 and out of a portion of sleeve 26 of structure 222. As described hereinabove, contracting member 226 can be threaded through tool 810 in a manner in which member 226 passes through distal tip 331, through contracting-member-fastener 360 that can be held in the open state, such as by prongs 337 of stop 362, through aligned ports 339 and 341 in distal end portion 333 of tool 810, and through secondary tube 340. For some applications, the distal end portion of tool 810 is similar to the distal end portion of tool 702 as described hereinabove with reference to <figref idref="f0023">Figs. 10A-B</figref>. For some applications, the distal end portion of tool 810 is similar to the distal end portion of tool 920 as shown hereinbelow with reference to <figref idref="f0025">Figs. 12</figref>, <figref idref="f0026">13</figref>, and <figref idref="f0028">15</figref>. For such applications, tool 920 comprises male coupling 925 and annuloplasty structure 222 comprises housing 930 shaped so as to define female coupling 927.

0404Tool 810 comprises a proximal handle portion 820. Handle portion 820 comprises a proximal contraction-facilitating knob 830. Knob 830 is fixedly coupled to a proximal end 832 of contracting member 226. Rotation of contraction-facilitating knob 830 as shown in <figref idref="f0024">Fig. 11A</figref> moves knob 830 proximally. As knob 830 is pulled proximally, contracting member 226 is pulled proximally. Responsively, annuloplasty structure 222 is contracted. Tool 810 comprise a gauge 834 indicating a level of contraction of the ring responsively to the number of rotations of knob 830.

0405As shown in <figref idref="f0024">Fig. 11B</figref>, once distal tip 331 of tool 810 contacts sleeve 26 of structure 222 (or for some applications a housing of annuloplasty structure, as described hereinabove with reference to <figref idref="f0025">Figs. 12</figref>, <figref idref="f0026">13</figref>, and <figref idref="f0028">15</figref>), tool 810 can be used to contract structure 222 by tool 810 pulling on contracting member 226 responsively to rotation of the knob 830 as described hereinabove with reference to <figref idref="f0024">Fig. 11A</figref>. During contraction of structure 222, fastener 360 is not deployed.

0406In <figref idref="f0024">Fig. 11C</figref>, contracting member 226 has been pulled tight, and annuloplasty structure 222 has been contracted and in a tense, contracted state. Distal end portion 333 of tool 810 is then used to eject and deploy fastener 360 from within tool 810 in order to lock structure 222 in the contracted state.

0407In some applications, once distal tip 331 contacts sleeve 26, a trigger knob 840 at handle portion 820 of tool 810 is pulled partially, in order to facilitate ejecting and deploying of contracting-member-fastener 360 from within a housing 332 of distal end portion 333. Fastener-ejector 335 is movable within distal end portion 333 of contracting-member-uptake tool 810. A proximal portion of ejector 335 is coupled to a distal portion of an actuating wire 842. A proximal end 844 of actuating wire 842 is coupled to trigger knob 840. Proximal movement of trigger knob 840 pulls proximally on actuating wire 842, which, in turn, pulls maximally fastener-ejector 335. Movement of fastener-ejector 335 proximally converts contracting-member-fastener 360 from its open state to its closed state to clamp onto contracting member 226 passed therethrough. Fastener-ejector 335 is coupled to prongs 337 of stop 362 in a manner in which when ejector 335 is moved proximally within portion 333, stop 362 is decoupled from contracting-member-fastener 360 as prongs 337 move proximally away from contracting-member-fastener 360. Once contracting-member-fastener 360 is no longer held in the open state by stop 362, fastener 360 closes, as it tends to do, and clamps around contracting member 226 passing therethrough.

0408Actuating wire 842 is disposed within an inner sheath 841 which runs the length of elongate sheath 310. For such applications, as shown in <figref idref="f0024">Figs. 11A-C</figref>, elongate sheath 310 comprises a multi-lumen sheath defining (1) a first lumen for passage therethrough of inner sheath 841 housing within it actuating wire 842, and (2) a second lumen for passage therethrough of contracting member 226.

0409As shown in <figref idref="f0024">Fig. 11C</figref>, fastener 360 has been ejected and deployed from within housing 332 of ejector 335. Subsequently, fastener-ejector 335 is moved further proximally in response to the further pulling proximally of trigger knob 840, in order to sever excess portions of contracting member 226. Similar to tool 300 and 600 described hereinabove, tool 810 is shaped so as to define a cutting-facilitating edge 370 in distal end portion 333 of tool 810. For some applications, cutting-facilitating edge 370 defines a sharp edge. While contracting member 226 passes through aligned ports 339 and 341 in distal end portion 333 of tool 810, as shown in <figref idref="f0024">Figs. 11A-C</figref>, contracting member 226 is in proximity with cutting-facilitating edge 370. Movement of fastener-ejector 335 proximally brings a cutting-facilitating edge 372 of ejector 335 against cutting-facilitating edge 370 of tool 810, thus sandwiching a portion of contracting member 226 between edges 370 and 372, in order to sever and cut contracting member 226 extending through ports 339 and 341. For some applications, cutting-facilitating edge 372 defines a sharp edge. <figref idref="f0024">Fig. 11C</figref> shows contracting member 226 severed once cutting-facilitating edge 372 of ejector 335 has been brought against cutting-facilitating edge 370 of tool 300.

0410Following the severing of contracting member 226, tool 810 is removed from the body of the patient by being withdrawn proximally, bringing together with it the excess portion of contracting member 226.

0411Reference is now made to <figref idref="f0024">Figs. 11A-C</figref>. For some applications, trigger knob 840 is coupled to a safety mechanism in order to prevent unintentional deployment of fastener 360.

0412Reference is now made to <figref idref="f0025">Figs. 12A-C</figref>, which are schematic illustrations of an example of a system 900 comprising an example annuloplasty structure 910 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) comprising a sleeve 26, a contracting member 226, and a lock 950. Implantable annuloplasty structure 910 comprises a primary body portion 912. Contracting member 226 has a first portion 914 extending along a longitudinal length of primary body portion 912 of annuloplasty structure 910, and a second portion 916 extending away from primary body portion 912 of annuloplasty structure 910. Contracting member 226 is configured to adjust a perimeter of annuloplasty structure 910.

0413Except for the differences described hereinbelow, annuloplasty structure 910 can be the same as or generally similar to annuloplasty structures 222, 522, and 730 described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024">Figs. 1-11C</figref> and like reference numerals refer to like parts. Annuloplasty structure 910 can be a full (or closed) or partial (or opened) annuloplasty structure.

0414Primary body portion 912 of structure 910 has a lateral wall and is shaped so as to define a recess 960 having a recess axis 940. Recess 960 extends from an opening 932 in a first surface 934 of the lateral wall of primary body portion 912 toward an opposite second surface 936 of the lateral wall of the primary body portion 912 (illustrated in <figref idref="f0025">Fig 12C</figref>). The lateral wall of primary body portion 912 extends away from recess 960 along a longitudinal axis 942 that is at a non-zero angle with respect to recess axis 940. Contracting member 226 extends through recess 960 and away from primary body portion 912 of annuloplasty structure 910 via recess 960.

0415Recess 960 is shaped so as to define a recess lumen 962. Recess lumen 962 is disposed along recess axis 940.

0416For some applications, primary body portion 912 comprises a housing 930 coupled to sleeve 26. For such applications, housing 930 defines at least a portion of the lateral wall and housing 930 defines recess 960. Sleeve 26 defines the remaining portion of the lateral wall.

0417For some applications, structure 910 does not comprise a housing 930, and sleeve 26 defines the lateral wall.

0418Recess 960 is shaped so as to receive lock 950. Recess 960 is dimensioned so as to compress lock 950 when lock 950 is disposed at least in part within recess 960. Lock 950 is shaped to as to define a series of tapered segments 951. Each segment 951 having a longest length L1 of 0.2-1.5 mm. A proximal-most section of lock 950 has a length L2 of 0.2-2 mm. Correspondingly, recess 960 corresponds to the shape of lock 950 and is slightly smaller than the shape of lock 950 such that the walls that define recess 960 compress lock 950 as it slides into recess 960. That is, the section of recess 960 that receives longest length L1 of segment 951 has a longest length L3 of 0.2-1.5 mm. A proximal-most section of recess 960 has a length L4 of 0.2-2 mm.

0419Lock 950 is shaped so as to define a lock lumen configured to surround contracting member 226. Lock 950 is shaped so as to define a longitudinal slit 952 which extends from a proximal surface of lock 950 toward a distal surface of lock 950. For some applications, slit 952 defines the lock lumen of lock 950. Slit 952 enables lock 950 to squeeze into the smaller recess 960 and thereby be compressed. When lock 950 is compressed, slit 952 enables lock 950 to close around contracting member 226 and thereby lock 950 to contracting member 226.

0420For some applications (not shown), the lock lumen has a dimension (e.g., a diameter) that is consistent along a length of the lock lumen from the proximal surface of lock 950 to a distal surface of lock 950.

0421As shown, for some applications, the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion of the lock lumen. For such applications, the proximal-most section of recess 960 is narrower than any other portion of recess 960 distal to the proximal-most portion.

0422A delivery tool 920 is used to deliver lock 950 to recess 960. Except for the differences described hereinbelow, delivery tool 920 can be the same as or generally similar to tools 300, 600, 702, and 810 described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024">Figs. 4A-11C</figref> and like reference numerals refer to like parts. Tool 920 comprises a contracting-member severing section 921 which can comprise elements of tools 300, 600, 702, and 810 described hereinabove with respect to the cutting elements.

0423As shown in <figref idref="f0025">Fig. 12A</figref>, delivery tool 920 delivers annuloplasty structure or annuloplasty structure 910 and lock 950 together toward the annulus. Delivery tool 920 and contracting member 226 are slidable with respect to each other. When delivery tool 920 is coupled to annuloplasty structure 910, a portion of contracting member 226 (e.g., second portion 916) is disposed within a lumen of delivery tool 920 and lock 950 surrounds a part of the contracting member. When delivery tool 920 is coupled to annuloplasty structure 910, lock 950 is disposed entirely proximally to recess 960.

0424<figref idref="f0025">Fig. 12B</figref> shows partial position of lock 950 within a proximal portion of recess 960. During the partial positioning of lock 950, the distal portion of lock 950 is compressed (e.g., a distal-most tapered segment 951). Since the distal portion of the lock lumen of lock 950 is wider than the proximal portion of the lock lumen, as the distal portion of lock 950 is compressed within the proximal portion of recess 960, the distal portion of lock 950 doesn't fully close around contracting member 226 such that at this stage, lock 950 is not locked with respect to contracting member 226 which would pull contracting member distally as lock 950 is pushed further distally within recess 960. Only once lock 950 has been pushed entirely within recess 960, since the proximal-most section of recess 960 is narrower than any other portion of recess 960 distal to the proximal-most portion, and since the lock lumen of lock 950 is narrower at a proximal portion 953 of lock 950, at least proximal portion 953 of lock 950 closes around contracting member 226 in order to lock 950 to contracting member and, thereby, maintain the perimeter of annuloplasty structure 910. That is, tool 920 pushes lock 950, often using a lock-ejector 923 which is similar to fastener-ejector 335 described hereinabove. Lock-ejector 923 is movable within a distal end portion of tool 920. Movement of lock-ejector 923 contacts and converts lock 950 from an open state (shown in <figref idref="f0025">Fig. 12A</figref>) to a closed state (shown in <figref idref="f0025">Fig. 12C</figref>) in order to clamp lock 950 onto contracting member 226 passed therethrough.

0425As shown in <figref idref="f0025">Fig. 12C</figref>, lock 950 is shaped so as to fit entirely within recess 960. As described hereinabove with reference to tools 300, 600, 702, and 810 described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024">Figs. 4A-11C</figref>, tool 920 is configured to sever excess portions of contracting member 226 following the locking of lock 950 to contracting member 226 by being positioned within recess 960. That is, the distal end portion of tool 920 is shaped so as to define a sharp edge, similar to edge 370 of tool 300 as described hereinabove. Additionally, as described hereinabove, contracting member 226 is disposed in proximity to the sharp edge such that movement of lock-ejector 923 against the sharp edge severs contracting member 226 extending through lock 950.

0426Reference is now made to <figref idref="f0026">Figs. 13A-C</figref>, which are schematic illustrations of an example of a system 1000 comprising an example annuloplasty structure or annuloplasty structure 910 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) comprising a sleeve 26, a contracting member 226, and a lock 1950. Except for the differences described herein below, system 1000 is the same or generally similar to system 900 as described hereinabove with reference to <figref idref="f0025">Figs. 12A-C</figref> with the exception that when delivery tool 920 is coupled to annuloplasty structure 910, lock 1950 is disposed at least in part and retained within recess a 1960. As shown, a distal-most tapered segment 951 is disposed within a proximal section of recess 1960. In such a manner, system 1000 reduces the possibility of embolism and/or clotting.

0427Reference is now made to <figref idref="f0023 f0024 f0025 f0026">Figs. 10A-13C</figref>. In <figref idref="f0023">Fig. 10A</figref>, tool 702 comprises an oversheath 710 at least a distal portion of tool 702. Oversheath 710 comprises grippers 720 which are configured to surround at least a portion of annuloplasty structure coupled to tool 702. For some applications, any of tools 300, 600, and 810 described herein comprise oversheath 710 comprising grippers 720. Grippers 720 and oversheath 710 are configured to provide a counterforce to the annuloplasty structure during deployment of the fasteners 360 and/or lock 950 described herein, because in order to deploy the fasteners 360 and/or lock 950, the fasteners 360 and/or lock 950 are pushed by the tool. For some applications, tools described herein do not comprise grippers 720.

0428Reference is now made to <figref idref="f0027">Fig. 14</figref>, which is a schematic illustration of an example system 1100 comprising a lock 1110 configured to lock a perimeter of an annuloplasty structure (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.), in accordance with some applications. Except for the differences described hereinbelow, lock 1110 can be generally similar to lock 950, described hereinabove with reference to <figref idref="f0025 f0026">Figs. 12A-13C</figref> and like reference numerals refer to like parts. Slit 952 of lock 1110 is uniform along a longitudinal axis of lock 1110 from a proximal end of lock 1110 to a distal end of lock 1110. For some applications, as shown in <figref idref="f0025 f0026">Figs. 12A-13C</figref>, the lock lumen is uniform. For some applications, as shown in <figref idref="f0028">Figs. 15A-C</figref>, the lock lumen is narrower at the proximal end portion and wider at the distal end portion of the lock.

0429Lock 1110 can be used to lock any annuloplasty structure described herein, for example, lock 1110 can be used to lock any of annuloplasty structures 222, 522, 730, and 910 described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026">Figs. 1-13C</figref>.

0430A delivery tool can be used to deliver lock 1110 toward the annuloplasty structure or annuloplasty ring structure. The delivery tool can be the same as or generally similar to tools 300, 600, 702, 810, and 920 described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026">Figs. 4A-13C</figref> and like reference numerals refer to like parts. The delivery tool comprises a contracting-member severing section which can comprise elements of tools 300, 600, 702, 810, and 920 described hereinabove with respect to the cutting elements.

0431Reference is now made to <figref idref="f0028">Figs. 15A-C</figref>, which are schematic illustrations of an example system 1480 comprising an example annuloplasty structure 910 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) comprising a sleeve 26, a contracting member 226, and a lock 1490, in accordance with some applications. Except for the differences described herein below, system 1480 is the same or generally similar to system 1000 as described hereinabove with reference to <figref idref="f0026">Figs. 13A-C</figref> with the exception that lock 1490 has a lumen that is narrower at the proximal end portion of lock 1490 and wider at the distal end portion of lock 1490. Section A-A of <figref idref="f0028">Fig. 15A</figref> shows the lock lumen being wider around contracting member 226 at the proximal end portion of lock 1490 than a width of the lock lumen around contracting member 226 at the distal end portion of lock 1490 shown in Section B-B. As shown in <figref idref="f0028">Fig. 15C</figref>, once lock 1490 is disposed entirely within recess 960, the proximal end portion closes tightly around contracting member 226, as shown in Section C-C, while the distal end portion closes around contracting member 226, which may not close as tightly as the proximal end portion closes around contracting member 226, as shown in Section D-D.

0432As shown, lock 1490 is shaped so as to define slit 952 that is narrower at the proximal end portion of lock 1490 and wider at the distal end portion of lock 1490.

0433For some applications, lock 1490 is shaped so as to define slit 952 that is uniform along the length of lock 1490 as shown in <figref idref="f0027">Fig. 14</figref>.

0434For some applications, when delivery tool 920 is coupled to annuloplasty structure 910, lock 1490 is disposed entirely proximally to recess 1960, as shown in <figref idref="f0025">Figs. 12A-C</figref>.

0435Reference is now made to <figref idref="f0029">Fig. 16</figref>, which is a schematic illustration of an example system 1200 comprising an example annuloplasty structure 1210 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) comprising a sleeve 26, a contracting member 226, and a lock 1220. Implantable annuloplasty structure 1210 comprises a primary body portion. Contracting member 226 has a first portion extending along a longitudinal length of the primary body portion of annuloplasty structure 1210, and a second portion extending away from the primary portion of annuloplasty structure 1210. Contracting member 226 is configured to adjust a perimeter of annuloplasty structure 1210.

0436Except for the differences described hereinbelow, annuloplasty structure 1210 can be the same as or generally similar to annuloplasty structures 222, 522, 730, and 910 described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026 f0027 f0028">Figs. 1-15C</figref> and like reference numerals refer to like parts. Annuloplasty structure 1210 can be a full (or closed) or partial (or opened) annuloplasty structure.

0437Structure 1210 comprises a housing 1202 shaped so as to define a lateral wall and is shaped so as to define a recess 1230 having a recess axis. Recess 1230 extends from an opening in a first surface of the housing toward an opposite second surface of housing 1202. Housing 1202 is shaped so as to provide a contracting-member-lumen wall 1205 which is disposed along a contracting-member lumen 1204. Contracting-member lumen 1204 is disposed at a non-zero angle with respect to a recess axis 1207 of recess 1230. Recess 1230 is shaped so as to define a recess lumen that is disposed along recess axis 1207.

0438Lock 1220 is shaped so as to define a lock-threaded-portion 1222. Housing 1202 of annuloplasty structure 1210 is shaped so as to define annuloplasty-structure-threaded-portion 1232 configured to engage with lock-threaded-portion 1222. In order to advance lock 1220 within recess 1230 of housing 1202, the physician uses a delivery tool in order to screw lock 1220 within housing 1202. The delivery tool can be the same as or generally similar to tools 300, 600, 702, 810, and 920 described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026">Figs. 4A-13C</figref> and like reference numerals refer to like parts. The delivery tool comprises a contracting-member severing section which can comprise elements of tools 300, 600, 702, 810, and 920 described hereinabove with respect to the cutting elements.

0439When lock 1220 is disposed within the recess, a distal surface of a distal end of lock 1220 is configured to pinch a first portion of contracting member 226 against contracting-member-lumen wall 1205 in order to lock contracting member 226 at least a first pinching point 1212.

0440For some applications, housing 1202 defines at least a portion of a lateral wall of the annuloplasty structure 1210, and housing 1202 defines recess 1230.

0441Lock 1220 is shaped so as to define a lock lumen 1221 configured to surround contracting member 226. Lock 1220 is shaped so as to define a longitudinal slit which extends from a proximal surface of lock 1220 toward a distal surface of lock 1220. For some applications, the slit defines lock lumen 1221 of lock 1220. The slit enables lock 1220 to squeeze into the smaller recess 1230 and thereby be compressed. When lock 1220 is compressed, the slit enables lock 1220 to close around contracting member 226 and thereby lock 1220 to contracting member 226.

0442For some applications, lock lumen 1221 has a dimension (e.g., a diameter) that is consistent along a length of lock lumen 1221 from the proximal surface of lock 1220 to a distal surface of lock 1220.

0443Reference is now made to <figref idref="f0028">Figs. 15A-C</figref>, and <figref idref="f0029">16</figref>. For some applications, lock lumen 1221 of lock 1220 is shaped so as to define a distal portion that is wider than a proximal portion of lock lumen 1221. For such applications, the proximal-most section of recess 1230 can be narrower than any other portion of recess 1230 distal to the proximal-most portion.

0444Reference is now made to <figref idref="f0025">Figs. 12A-C</figref>, <figref idref="f0026">13A-C</figref>, <figref idref="f0028">15A-C</figref>, and <figref idref="f0029">16</figref>. For some applications, the slit of lock 1220 is wider at the distal end portion of lock 1220 and narrower at the proximal end portion of lock 1220.

0445Reference is now made to <figref idref="f0027">Figs. 14</figref> and <figref idref="f0029">16</figref>. For some applications, the slit of lock 1220 is uniform along the length of the slit. For some applications, lock lumen 1221 is uniform along the length of lock 1220.

0446Reference is now made to <figref idref="f0029">Fig. 17</figref>, which is a schematic illustration of an example system 1300 comprising an example annuloplasty structure 1310 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.) comprising a sleeve 26, a contracting member 226, and a lock 1320. Implantable annuloplasty structure 1310 comprises a primary body portion. Contracting member 226 has a first portion extending along a longitudinal length of the primary body portion of annuloplasty structure 1310, and a second portion extending away from the primary portion of annuloplasty structure 1310. Contracting member 226 is configured to adjust a perimeter of annuloplasty structure 1310.

0447Except for the differences described hereinbelow, annuloplasty structure 1310 can be the same as or generally similar to annuloplasty structures 222, 522, 730, and 910 described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026 f0027 f0028">Figs. 1-15C</figref> and like reference numerals refer to like parts. Annuloplasty structure 1310 can be a full (or closed) or partial (or opened) annuloplasty structure.

0448Structure 1310 comprises a housing 1302 shaped so as to define a lateral wall and is shaped so as to define a recess 1330 having a recess axis. Recess 1330 extends from an opening in a first surface of the housing toward an opposite second surface of housing 1302. Housing 1302 is shaped so as to provide a contracting-member-lumen wall 1305 which is disposed along a contracting-member lumen 1304. Contracting-member lumen 1304 is disposed at a non-zero angle with respect to a recess axis 1307 of recess 1330. Recess 1330 is shaped so as to define a recess lumen that is disposed along recess axis 1307.

0449Lock 1320 is shaped so as to define a lock-threaded-portion 1222. Housing 1302 of annuloplasty structure 1310 is shaped so as to define annuloplasty-structure-threaded-portion 1332 configured to engage with lock-threaded-portion 1322. In order to advance lock 1320 within recess 1330 of housing 1302, the physician uses a delivery tool in order to screw lock 1320 within housing 1302. The delivery tool can be the same as or generally similar to tools 300, 600, 702, 810, and 920 described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026">Figs. 4A-13C</figref> and like reference numerals refer to like parts. The delivery tool comprises a contracting-member severing section which can comprise elements of tools 300, 600, 702, 810, and 920 described hereinabove with respect to the cutting elements.

0450When lock 1320 is disposed within the recess, a distal surface of a distal end of lock 1320 is configured to pinch a first portion of contracting member 226 against contracting-member-lumen wall 1305 in order to lock contracting member 226 at least a first pinching point 1312. Lock 1320 is shaped so as to define a lock lumen 1321 along a longitudinal length and a lock-distal-tapered-portion 1334. Housing 1302 and recess 1330 are shaped so as to define a recess-distal-tapered-portion 1324. When lock 1320 is disposed within recess 1330, and lock-distal-tapered-portion 1334 is within recess-distal-tapered-portion 1324, recess-distal-tapered-portion 1324 is configured to compress lock-distal-tapered-portion 1334 which, in turn, is configured to pinch a second portion of contracting member 226 within lock lumen 1321 at recess-distal-tapered-portion 1324 in order to lock contracting member 226 at least a second pinching point 1314.

0451For some applications, housing 1302 defines at least a portion of a lateral wall of the annuloplasty structure 1310, and housing 1302 defines recess 1330.

0452Lock lumen 1321 configured to surround contracting member 226. Lock 1320 is shaped so as to define a longitudinal slit which extends from a proximal surface of lock 1320 toward a distal surface of lock 1320. For some applications, the slit defines lock lumen 1321 of lock 1320. The slit enables lock 1320 to squeeze into the smaller recess 1330 and thereby be compressed. When lock 1320 is compressed, the slit enables lock 1320 to close around contracting member 226 and thereby lock 1320 to contracting member 226.

0453For some applications, lock lumen 1321 has a dimension (e.g., a diameter) that is consistent along a length of lock lumen 1321 from the proximal surface of lock 1320 to a distal surface of lock 1320.

0454Reference is now made to <figref idref="f0028">Figs. 15A-C</figref>, and <figref idref="f0029">17</figref>. For some applications, lock lumen 1321 of lock 1320 is shaped so as to define a distal portion that is wider than a proximal portion of lock lumen 1321. For such applications, the proximal-most section of recess 1330 can be narrower than any other portion of recess 1330 distal to the proximal-most portion.

0455Reference is now made to <figref idref="f0025">Figs. 12A-C</figref>, <figref idref="f0026">13A-C</figref>, <figref idref="f0028">15A-C</figref>, and <figref idref="f0029">17</figref>. For some applications, the slit of lock 1320 is wider at the distal end portion of lock 1320 and narrower at the proximal end portion of lock 1320.

0456Reference is now made to <figref idref="f0027">Figs. 14</figref> and <figref idref="f0029">17</figref>. For some applications, the slit of lock 1320 is uniform along the length of the slit. For some applications, lock lumen 1321 is uniform along the length of lock 1320.

0457Reference is now made to <figref idref="f0029">Figs. 16-17</figref>. Systems 1200 and 1300 provide a locking assembly which allows for the operating physician to readjust the perimeter of the annuloplasty structure post-locking. For example, if the physician would like to readjust once locks 1220 and 1320 are in place, the physician is able to unscrew locks 1220 and 1230 respectively in order to readjust the perimeter of the annuloplasty structure by giving slack to or tightening contracting member 226 without disengaging locks 1220 and 1300 from the respective recess 1230 and 1330. Subsequently to the readjusting of contracting member 226, locks 1220 and 1320 are repositioned within the respective recess 1230 and 1330.

0458Reference is now made to <figref idref="f0030">Fig. 18</figref>, which is a schematic illustration of an example of a system 1350 for contracting annulus 240 of the patient using an annuloplasty structure 522 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.), which can comprise a housing 530. Housing 530 can house a contracting-member-fastener 1360. Except for the differences described hereinbelow, annuloplasty structure 522 can be the same as or generally similar to annuloplasty structure 222, described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016">Figs. 1-7E</figref> and like reference numerals refer to like parts.

0459Annuloplasty structure or annuloplasty ring structure 522 can comprise sleeve 26 which can define a primary body portion of structure 522. Structure 522 comprises contracting member 226 having a first portion extending along a longitudinal length of the primary body portion of annuloplasty structure 522. Contracting member 226 also defines a second portion extending away from the primary body portion of annuloplasty structure 522.

0460Contracting member 226 can extend through housing 530 and through a stop 570 (e.g., a holder) that is disposed within an opening of contracting-member-fastener 1360. Stop 570 is shown as being cylindrical by way of illustration and not limitation. The outer surface of stop 570 maintains fastener 1360 in the open state. Stop 570 is shaped so as to define a threaded portion which enables coupling thereto of contracting-member-uptake tool 600, as is described hereinabove.

0461Annuloplasty structure or annuloplasty ring structure 522 is implanted as described hereinabove with reference to <figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref> using the system described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008">Figs. 1-3I</figref>.

0462Housing 530 can be coupled to sleeve 26 of structure 522 at any suitable location along structure 522. For example, housing 530 can be coupled to sleeve 26 of structure 522 at a portion of structure 522 in a vicinity of a left fibrous trigone of the valve, as shown. For some applications, housing 530 can be coupled to sleeve 26 of structure 522 at a portion of structure 522 in a vicinity of a right fibrous trigone of the valve. For some applications, housing 530 can be coupled to sleeve 26 of structure 522 at a middle portion of structure 522. As shown, housing 530 can be coupled to a lateral surface of sleeve 26. In such applications, housing 530 does not block them lumen of sleeve 26 of structure 522.

0463Fastener 1360 is generally similar to fastener 360 of <figref idref="f0017 f0018 f0019 f0020">Figs. 8A-D</figref>, with the exception that fastener 1360 is shaped so as to define intersecting slits 1362 which form the opening of fastener 1360 through which contracting member 226 passes into a generally "X" or generally "+" (plus) shape.

0464<figref idref="f0030">Fig. 18</figref> shows contracting member 226 being severed proximal to fastener 1360 and excess portions of contracting member 226 being removed from the body of the patient using tool 600. Severing of contracting member 226 can be performed in a manner as described hereinabove with reference to <figref idref="f0015 f0016">Figs. 7A-E</figref>, <i>mutatis mutandis.</i>

0465Reference is now made to <figref idref="f0031">Figs. 19A-B</figref>, which are schematic illustrations of an example of a system 1400 for contracting the annulus of the patient using an annuloplasty structure (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.), which can be coupled to a housing 1430. Housing 1430 can house a contracting-member-fastener 1460. For some applications, the annuloplasty structure can be the same as or generally similar to annuloplasty structure 222, described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016">Figs. 1-7E</figref> and like reference numerals refer to like parts. For some applications, the annuloplasty structure comprises housing 1430. For some applications, housing 1430 is discrete from the annuloplasty structure and deliverable and couplable to the annuloplasty structure only once the annuloplasty structure has been anchored to the annulus.

0466Housing 1430 can be coupled to the sleeve 26 of the annuloplasty structure at any suitable location along the annuloplasty structure. For example, housing 1430 can be coupled to the sleeve 26 of the annuloplasty structure at a portion of the annuloplasty structure in a vicinity of a left fibrous trigone of the valve, as shown. For some applications, housing 1430 can be coupled to the sleeve of the annuloplasty structure at a portion of the annuloplasty structure in a vicinity of a right fibrous trigone of the valve. For some applications, housing 1430 can be coupled to the sleeve of the annuloplasty structure at a middle portion of the annuloplasty structure. As shown, housing 1430 can be coupled to a lateral surface of the sleeve. In such applications, housing 1430 does not block them lumen of the sleeve of the annuloplasty structure.

0467The annuloplasty structure or annuloplasty ring structure can comprise the sleeve which can define a primary body portion of the structure. The structure comprises contracting member 226 having a first portion extending along a longitudinal length of the primary body portion of annuloplasty structure. The contracting member also defines a second portion extending away from the primary body portion of the annuloplasty structure.

0468Fastener 1460 is shaped so as to define a generally-rectangular, planar clip comprising a super-elastic material, e.g., nitinol. Fastener 1460 comprises a deformable element shaped so as to define a plurality of slits which are surrounded by a plurality of flexible legs 1462 which enable the clip to transition between slanted (<figref idref="f0031">Fig. 19A</figref>) and straight (<figref idref="f0031">Fig. 19B</figref>) states. The contracting-wire-engaging surface of the clip is shaped to define a plurality of teeth 1464. For some applications, teeth 1464 are jagged. For some applications, the upper surface of the clip does not comprise teeth 1464 and is flat. Teeth 1464 are configured to increase friction between contracting member 226 and fastener 1460.

0469Fastener 1460 comprises a clamping structure that is (a) biased toward assuming a closed state (<figref idref="f0031">Fig. 19B</figref>). In the closed state, the clamping structure is configured to clamp onto contracting member 226 passed therethrough, and (b) can be flexed to an open state (<figref idref="f0031">Fig. 19A</figref>) through which contracting member 226 can move.

0470Contracting member 226 can extend through a channel 1434 of housing 1430 and through a stop 1470 (e.g., a holder) that is disposed within an opening of contracting-member-fastener 1460. Channel 1434 extends along a longitudinal axis 1410 of housing 1430. Stop 1470 can be shaped so as to define a lumen therethrough for surrounding contracting member 226 and is shown as being shaped to as to define a larger cylindrical section that is engageable by a tool, and a narrower cylindrical engager 1472. Engager 1472 can be shaped so as to fit snugly within channel 1434 such that it pushes against the contracting-wire-engaging surface of the clip and maintains fastener 1460 in a slanted state, i.e., an unlocked state of fastener 1460. In the slanted state as shown in <figref idref="f0031">Fig. 19A</figref>, the clip is deformed and does not push against contracting member 226. In the slanted state, contracting member 226 is free to move with respect to fastener 1460, housing 1430, and stop 1470. Contracting member 226 is pulled until it sufficiently contracts the annuloplasty structure.

0471In <figref idref="f0031">Fig. 19B</figref>, stop 1470 has been decoupled and removed from housing 1430. In the absence of force applied to the contracting-wire-engaging surface of the clip by engager 1472, the clip returns to its resting, straight state and traps contracting member 226 between the contracting-wire-engaging surface of the clip and a surface 1432 of housing 1430, e.g., an inner wall. As such, fastener 1460 is now in a locked state in which the clip locks and crimps contracting member 226.

0472Reference is now made to <figref idref="f0032 f0033 f0034">Figs. 20A-F</figref>, which are schematic illustrations of an example of a portion of a multi-component tubular system 1500 comprising a contracting-member-severing tool 1502 and a contracting-member-uptake tool 1600, described hereinbelow with reference to <figref idref="f0035 f0036 f0037 f0038 f0039 f0040">Figs. 21A-26B</figref>. Contracting member 226 is threaded through and passes through contracting-member severing tool 1502 and through contracting-member-uptake tool 1600. Contracting member 226 can be ensnared by tool 1502 using a snare as described herein above with regard to snare 350 with reference to <figref idref="f0009 f0010 f0011 f0012">Figs. 4A-5D</figref>. Tool 1502 can be advanced along contracting member 226 toward an annuloplasty structure 1522 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.). For some applications, tool 1502 is advanced toward a housing 1530 that is already coupled to structure 1522, in a manner similar to tool 300 advancing along contracting member 226, as described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012">Figs. 4A-5D</figref>. Annuloplasty structure 1522 can comprise a flexible primary body portion. Contracting member 226 has a first portion extending along a longitudinal length of the primary body portion. A second portion of contracting member 226 can extend away from the primary body portion of annuloplasty structure 1522 and outside the body of the patient.

0473System 1500 is used to contract the annulus of the patient using annuloplasty structure 1522 (e.g., an annuloplasty ring structure, a closed annuloplasty structure, a closed annuloplasty ring structure, an open annuloplasty structure, a partial annuloplasty ring structure, etc.), which can comprise a housing 1530. Housing 1530 can house a contracting-member-fastener 1560. Except for the differences described hereinbelow, annuloplasty structure 1522 can be the same as or generally similar to annuloplasty structure 222, described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016">Figs. 1-7E</figref> and like reference numerals refer to like parts.

0474It is to be noted that fastener 1560 can comprise fasteners 360 described hereinabove with reference to <figref idref="f0009 f0010">Figs. 4A-B</figref>, <figref idref="f0015 f0016">7A-E</figref>, <figref idref="f0017 f0018 f0019 f0020">8A-D</figref>, <figref idref="f0021 f0022">9A-D</figref>, <figref idref="f0023">10A-B</figref>, and <figref idref="f0024">11A-C</figref>, lock 950 described hereinabove with reference to <figref idref="f0025">Figs. 12A-C</figref>, lock 1950 described hereinabove with reference to <figref idref="f0025">Figs. 12A-C</figref>, lock 1110 described hereinabove with reference to <figref idref="f0027">Fig. 14</figref>, lock 1490 described hereinabove with reference to <figref idref="f0028">Figs. 15A-C</figref>, lock 1220 described hereinabove with reference to <figref idref="f0029">Fig. 16</figref>, lock 1320 described hereinabove with reference to <figref idref="f0029">Fig. 17</figref>, or any other fastener, lock, and/or crimp known in the art.

0475Annuloplasty structure or annuloplasty ring structure 1522 can comprise sleeve 26 which can define a primary body portion of structure 1522. Structure 1522 comprises contracting member 226 having a first portion extending along a longitudinal length of the primary body portion of annuloplasty structure 1522. Contracting member 226 also defines a second portion extending away from the primary body portion of annuloplasty structure 1522.

0476Contracting member 226 can extend through housing 1530 and through a stop 1570 (e.g., a holder) that is disposed within an opening of contracting-member-fastener 1560. Stop 1570 is shaped so as to define a lumen therethrough for surrounding contracting member 226 and is shown as being shaped to as to define a larger cylindrical section that is engageable by a tool, and a narrower cylindrical engager 1574. The outer surface of engager 1574 maintains fastener 1560 in the open state, as shown in <figref idref="f0032 f0033">Figs. 20A-D</figref>. Stop 1570 is shaped so as to define an overhang 1572, which enables coupling thereto of contracting-member-severing tool 1502, as is described hereinbelow.

0477Annuloplasty structure or annuloplasty ring structure 1522 is implanted as described hereinabove with reference to <figref idref="f0003 f0004 f0005 f0006 f0007 f0008">Figs. 3A-I</figref> using the system described hereinabove with reference to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008">Figs. 1-3I</figref>.

0478Housing 1530 can be coupled to sleeve 26 of structure 1522 at any suitable location along structure 1522. For example, housing 1530 can be coupled to sleeve 26 of structure 1522 at a portion of structure 1522 in a vicinity of a left fibrous trigone of the valve, as shown. For some applications, housing 1530 can be coupled to sleeve 26 of structure 1522 at a portion of structure 1522 in a vicinity of a right fibrous trigone of the valve. For some applications, housing 1530 can be coupled to sleeve 26 of structure 1522 at a middle portion of structure 1522. As shown, housing 1530 can be coupled to a lateral surface of sleeve 26. In such applications, housing 1530 does not block them lumen of sleeve 26 of structure 1522.

0479<figref idref="f0032">Fig. 20A</figref> shows contracting-member-severing tool 1502 through which contracting member 226 has been threaded. Contracting member 226 can be ensnared by tool 1502 using a snare as described herein above with regard to snare 350 with reference to <figref idref="f0009 f0010 f0011 f0012">Figs. 4A-5D</figref>. Tool 1502 can be advanced along contracting member 226 toward housing 1530 of structure 1522, in a manner similar to tool 300 advancing along contracting member 226, as described hereinabove with reference to <figref idref="f0009 f0010 f0011 f0012">Figs. 4A-5D</figref>.

0480Once tool 1502 is threaded along contracting member 226, contracting member 226 extends from sleeve 26, through engager 1574, through the proximal portion of stop 1570, through cutting elements 1510 and 1520 of tool 1502, and through the remaining proximal portion of tool 1502. As such, contracting member 226 is disposed in a vicinity of the cutting elements. Contracting member 226 is disposed along a longitudinal axis 1511 of tool 1502 along the entire length of tool 1502. The relative spatial orientation of the components of tool 1502 enable contracting member 226 to pass straightly and directly though the lumen of tool 1502 and along axis 1511 without taking a winding path through tool 1502. This direct and unwinding path of member 226 through tool 1502 reduces friction of member 226 as it moves within tool 1502. This direct path for contracting member 226 is enabled due to the orientation of components of tool 1502, as opposed to the winding path member 226 through tools 300, 600, 810, and 920 described hereinabove. The reduces friction on contracting member 226 reduces noise during the measurement of tension of the contracting member 226, as described hereinbelow with reference to <figref idref="f0035 f0036 f0037 f0038 f0039 f0040">Figs. 21A-26B</figref>.

0481Tool 1502 comprises an inner tube 1504 that is slidable with respect to an outer sleeve portion 1508. The distal end of inner tube 1504 is shaped so as to define graspers 1505, or fastener-ejectors. Since the distal end portion of tube 1504 is slotted, and since graspers 1505 are sloped, graspers 1505 have a tendency to be pushed radially outwardly in the presence of a force applied thereto by overhang 1572. Once tube 1504 is pushed sufficiently distally, graspers 1505 pass distally around overhang 1572 and close around stop 1570 at a site distal to overhang 1572, as shown in <figref idref="f0032">Fig. 20B</figref>. Graspers 1505 provide the primary and initial coupling and locking of tool 1502 to housing 1530 by gripping overhang 1572.

0482Tool 1502 comprises a static cutting element 1510 and a moveable, dynamic cutting element 1520. Static cutting element 1510 is shaped so as to define a concave cutting surface 1512 (i.e., a sharp edge), and dynamic cutting element 1520 is shaped so as to define a concave cutting surface 1521 (i.e., a sharp edge) which opposes concave cutting surface 1512 of static cutting element 1510. As is described hereinbelow, dynamic cutting element 1520 slides proximally and diagonally with respect to static cutting element 1510, along concave cutting surface 1512 of static cutting element 1510.

0483Once stop 1570 is engaged by inner tube 1504, outer sleeve portion 1508 is moved distally along inner tube 1504 and toward housing 1530 until a distal end of outer sleeve portion 1508 contacts a proximal end of housing 1530, as shown in <figref idref="f0033">Fig. 20C</figref>. Such distal movement of portion 1508 locks in place tube 1504 with respect to stop 1570 and thereby locks in place tool 1502 with respect to housing 1530. Since graspers 1505 are slanted, they are able to slide proximally around overhang 1572 in response to proximal pulling of tool 1502. Thus, surrounding the slotted distal end portion of tube 1504 and surrounding graspers 1505 of tube 1504 by outer sleeve portion 1508 prevents radial movement of graspers 1505 responsively to application of a proximal pulling force to stop 1570 by tool 1502 during the release of fastener 1560 in order to lock contracting member 226 in place and retain annuloplasty structure 1522 in a tensed state, as will be described hereinbelow. Outer sleeve portion 1508 thus locks graspers 1505 with respect to overhang 1572 and provides a secondary coupling and locking of tool 1502 to housing 1530.

0484Static cutting element 1510 comprises a pin 1513 which slides proximally and distally within a slit 1515 of tube 1404. As such, static cutting element 1510 is coupled to tube 1404, and to the tube surrounding tube 1404. That is, pin 1513 is coupled to outer sleeve portion 1508. As outer sleeve portion 1508 is moved distally, as shown in <figref idref="f0033">Fig. 20C</figref>, pin 1513 moves distally within slit 151 and static cutting element 1510 and dynamic cutting element 1520 are pushed distally within tube 1404. In this state, a distal surface 1523 of dynamic cutting element 1520 is still disposed at a distance from a proximal surface 1571 of stop 1570.

0485<figref idref="f0033">Fig. 20D</figref> shows contracting of annuloplasty structure 1522 responsively to proximal pulling of contracting member 226 by tool 1502. During the pulling of contracting member 226, tool 1502 remains coupled to housing 1530 due to graspers 1505 grasping overhang 1572 while outer sleeve portion 1508 surrounds the distal portion of inner tube 1504 and surrounds graspers 1505.

0486Tool 1502 can comprise a contracting-member-uptake device 322 of tool 300 as described hereinabove with reference to <figref idref="f0009 f0010">Figs. 4A-B</figref>. The contracting-member-uptake device can be used to contract contracting member 226. Once contracting member 226 is contracted and structure 1522 is contracted, as shown in <figref idref="f0033">Fig. 20D</figref>, tool 1502 removes stop 1570 by pulling stop 1570 proximally away from fastener 1560, as is described in <figref idref="f0034">Fig. 20E</figref>. While maintaining distal force to outer sleeve portion 1508, tube 1404 is pulled proximally with respect to portion 1508. Pulling of tube 1504 proximally pulls on stop 1570 since graspers 1505 maintain grasp on overhang 1572 of stop 1570 due to the presence of outer sleeve portion 1508. During the pulling of tube 1504 proximally, outer sleeve portion 1508 prevents radial outward movement of graspers 1505 as proximal force is being applied to tube 1504. Tube 1504 is pulled proximally until stop 1570 is disengaged from housing 1530, i.e., until engager 1574 of stop 1570 is decoupled and disengaged from fastener 1560, as shown in <figref idref="f0034">Fig. 20E</figref>. Since fastener 1560 tends to close, in the absence of stop 1570, fastener 1560 closes and clamps around contracting member 226 passing through fastener 1560. In such a manner, structure 1522 is locked by fastener 1560, and the contracted state of structure 1522 is maintained.

0487As stop 1570 is pulled proximally, proximal surface of stop 1570 hammers into distal surface 1523 of dynamic cutting element 1520. Responsively to the pushing of stop 1570 against dynamic cutting element 1520, dynamic cutting element 1520 is pushed proximally such that dynamic cutting element 1520 moves diagonally proximally. Cutting surface 1521 of dynamic cutting element 1520 and cutting element 1520 slide diagonally proximally along cutting surface 1512 of static cutting element 1510. The portion of contracting member 226 disposed between cutting surfaces 1512 and 1521 is severed. Since cutting surfaces 1512 and 1521 are concave and face each other, surfaces 1512 and 1521 compress contracting member 226 during the cutting, and thereby, contracting member 226 is severed cleanly and without fraying.

0488Thus, tool 1502 is arranged such that tool 1502 advantageously provides a safety mechanism by which contracting member 226 can only be severed by proximal force applied thereto by stop 1570 after fastener 1560 has been transitioned into the fastened, or locked, state and locks in place contracting member 226. That is, tool 1502 cannot inadvertently sever contracting member 226 all the while tool 1502 is not coupled to stop 1570 and all the while stop 1570 does not push against cutting element 1520. In one swift motion, tool 1502 (1) locks in place contracting member 226 by transitioning fastener 1560 into the locked state, and (2) severs contracting member 226.

0489<figref idref="f0034">Fig. 20F</figref> shows contracting member 226 after having been severed proximal to fastener 1560, and excess portions of contracting member 226 being removed from the body of the patient using tool 1502. The entire tool 1502 is pulled proximally in order to decouple tool 1502 from housing 1530 and from structure 1522 carrying stop 1570 within the lumen of tool 1502. Since stop 1570 is no longer coupled to housing 1530, a simple proximal pull on tool 1502 is enough to decouple tool 1502 from annuloplasty structure 1522.

0490Reference is again made to <figref idref="f0032 f0033 f0034">Figs. 20A-F</figref>. It is to be noted that although tool 1502 is described as being advanceable toward housing 1530 that is already coupled to annuloplasty structure 1522, the scope herein includes tool 1502 being coupled to housing 1530 from a site outside the body of the patient and being configured to deliver housing 1530 along contracting member 226 to sleeve 26 of structure 1522 that is already implanted at the annulus. For such applications, housing 1530 is configured to be positionable against the primary body portion of structure 1522.

0491Reference is now made to <figref idref="f0035 f0036 f0037 f0038 f0039 f0040">Figs. 21A-26B</figref>, which are schematic illustrations of another portion of multi-component tubular system 1500, described hereinabove with reference to <figref idref="f0032 f0033 f0034">Figs. 20A-F</figref>, comprising contracting-member-uptake tool 1600, which is configured to contract flexible elongated contracting member 226, in accordance with some applications. <figref idref="f0035">Figs. 21A-B</figref> show contracting-member-uptake tool 1600 before insertion of flexible elongated contracting member 226, and <figref idref="f0036 f0037 f0038 f0039 f0040">Figs. 22A-26B</figref> show contracting-member-uptake tool 1600 after insertion of flexible elongated contracting member 226.

0492Multi-component tubular system 1500 is used with an implant comprising an implantable structure and flexible elongated contracting member 226 that extends away from the implantable structure. The implant may comprise any of the implants described herein, such as implantable annuloplasty structure 222, which may, for example, comprise flexible sleeve 26. Alternatively, the implant may comprise another implant known in the art (including those described in the patents and patent application publications incorporated hereinbelow by reference), which may or may not comprise a sleeve.

0493Contracting-member-uptake tool 1600 comprises a handle portion 1620, which optionally may be supported by a stand, such as described hereinabove with reference to <figref idref="f0001 f0002">Figs. 1-2</figref>. Handle portion 1620 can comprise one, some, or all of: <ul id="ul0004" list-style="bullet"><li>an outer housing 1632, which can be shaped ergonomically for holding by a user (e.g., a physician, healthcare professional, etc.);</li><li>a tubular shaft 1634, disposed at least partially within outer housing 1632;</li><li>an inner shaft 1636, which (a) is partially disposed within a proximal longitudinal portion 1637 of tubular shaft 1634, such that inner shaft 1636 is axially slidable with respect to tubular shaft 1634, and (b) is shaped so as to define an inner-shaft contracting-member-receiving channel 1638;</li><li>a distal force applicator 1642, which (a) is disposed at least partially within a distal longitudinal portion of tubular shaft 1634, and (b) is shaped so as to define a distal-force-applicator contracting-member-receiving channel 1644, which allows sliding of contracting member 226 therethrough;</li><li>a spring 1646, which is disposed within tubular shaft 1634, connecting distal force applicator 1642 and a distal portion 1647 of inner shaft 1636; and</li><li>a contraction-facilitating knob 1630, which is accessible from outside outer housing 1632.</li></ul>

0494Handle portion 1620 is shaped so as to define a handle contracting-member-receiving channel 1650 from a distal end through to a proximal end of handle portion 1620 (as used in the present application, including in the claims, "proximal" means toward the user, i.e., away from the implant; with reference to <figref idref="f0035 f0036 f0037 f0038 f0039 f0040">Figs. 21A-26B</figref>, "proximal" means to the right in the drawings). Handle contracting-member-receiving channel 1650 includes inner-shaft contracting-member-receiving channel 1638, distal-force-applicator contracting-member-receiving channel 1644, and optionally additional contracting-member-receiving channels of handle portion 1620. A portion of contracting member 226 is threaded through handle contracting-member-receiving channel 1650 either after or before the implantable structure and contracting member 226 are advanced toward the heart of the patient.

0495Inner shaft 1636 can comprise a lock 1640, which is configured (i) when in an unlocked state, to allow sliding of contracting member 226 with respect to inner-shaft contracting-member-receiving channel 1638, and (ii) when in a locked state, to axially lock contracting member 226 with respect to inner shaft 1636. Optionally, lock 1640 applies friction to axially lock contracting member 226 with respect to inner shaft 1636,such as using a set screw or a lever, as is known in the art.

0496Handle portion 1620 is configured such that actuation of contraction-facilitating knob 1630, when contracting member 226 is disposed passing entirely through handle contracting-member-receiving channel 1650 and lock 1640 is in the locked state, causes handle portion 1620 to uptake successive portions of contracting member 226. <figref idref="f0036">Figs. 22A-B</figref> show handle portion 1620 before actuation of contraction-facilitating knob 1630, when contracting member 226 is disposed passing entirely through handle contracting-member-receiving channel 1650 and lock 1640 is in the locked state. <figref idref="f0037">Figs. 23A-B</figref>, <figref idref="f0038">24A-B</figref>, and <figref idref="f0039">25A-B</figref> show handle portion 1620 after successive levels of actuation of contraction-facilitating knob 1630, as described below.

0497As shown in <figref idref="f0035">Figs. 21A-B</figref> and <figref idref="f0036">22A-B</figref>, before initial actuation of contraction-facilitating knob 1630, the portion of contracting member 226 between handle portion 1620 and the implant may be somewhat slack or at most minimally tensed. A proximal end 1652 of tubular shaft 1634 and a proximal end 1654 of inner shaft 1636 are disposed at an initial offset distance D1 therebetween, indicative of essentially no tension in contracting member 226, i.e., that contracting member 226 is not tensed. For applications in which the implant comprises implantable annuloplasty structure 222, which comprises flexible sleeve 26, sleeve 26 (coupled to annulus 240) is in a relaxed, non-tense state. At this point, the tool has been sufficiently advanced through vasculature of the patient such that the distal tip of the tool is in proximity to structure 222 disposed along the annulus.

0498As shown, for example, in the transition between <figref idref="f0036">Figs. 22A-B</figref> and <figref idref="f0037">Figs. 23A-B</figref>, the actuation of contraction-facilitating knob 1630 can cause handle portion 1620 to uptake successive portions of contracting member 226 by: <ul id="ul0005" list-style="none"><li>advancing tubular shaft 1634 proximally with respect to outer housing 1632,</li><li>which advances distal force applicator 1642 proximally with respect to outer housing 1632 (distal force applicator 1642 can be axially fixed to tubular shaft 1634 during ordinary use of handle portion 1620),</li><li>which applies a proximally-directed force to spring 1646,</li><li>which pushes inner shaft 1636 proximally with respect to outer housing 1632 (by spring 1646 applying a proximally-directed force to inner shaft 1636,</li><li>which proximally pulls contracting member 226 (which is axially locked to inner shaft 1636 by lock 1640, as described above).</li></ul>

0499Sometimes, during the initial proximal movement of distal force applicator 1642 with respect to outer housing 1632 illustrated in the transition between <figref idref="f0036">Figs. 22A-B</figref> and 23A-B, contracting member 226 is relatively slack, as mentioned above, such that inner shaft 1636 offers no or relatively little resistance to the proximally-directed force applied to inner shaft 1636 by spring 1646, and spring 1646 is not, or is only minimally, axially compressed. As a result, inner shaft 1636 advances proximally with respect to the outer housing 1632 to the same, or approximately the same, extent as the tubular shaft 1634 advances proximally with respect to the outer housing 1632, and the offset distance remains at its initial value (D1), indicating that there is still essentially no tension in contracting member 226. This initial proximal advancement of tubular shaft 1634 and inner shaft 1636 with respect to outer housing 1632 serves to accommodate differing initial levels of slack in contracting member 226.

0500At a certain distance of proximal advancement of distal force applicator 1642 with respect to outer housing 1632, contracting member 226 becomes tensed (at an initial low level of tension), such that inner shaft 1636 gradually offers increasing resistance to the proximally-directed force applied to inner shaft 1636 by spring 1646, and spring 1646 becomes gradually more compressed. As used in the present application, including in the claims, contracting member 226 is considered to be "tensed" even when tensed at a low level of tension.

0501As shown in the transition between <figref idref="f0037">Figs. 23A-B</figref> and <figref idref="f0038">24A-B</figref>, as spring 1646 becomes more compressed, distal force applicator 1642 moves axially closer to inner shaft 1636, such that tubular shaft 1634 moves proximally with respect to inner shaft 1636. As a result, spring 1646 pushes inner shaft 1636 proximally with respect to outer housing 1632 to a lesser extent than tubular shaft 1634 proximally advances with respect to outer housing 1632, and proximal pulling of the contracting member 226 by the inner shaft 1636 increases tension in the contracting member 226. Therefore, the offset distance between proximal end 1652 of tubular shaft 1634 and proximal end 1654 of inner shaft 1636 decreases to a tensed offset distance D2, as shown in <figref idref="f0038">Figs. 24A-B</figref>. (In actual use of the handle, many tensed offset distances D2 occur; a single offset is shown for the sake of illustration.) The tensed offset distance D2 is less than the initial offset distance D1, reflecting the fact that the portion of inner shaft 1636 that protrudes from proximal end 1652 of tubular shaft 1634 has decreased.

0502Contraction-facilitating knob 1630 can have any shape that enables actuation thereof, and is not necessarily round, tubular, or generally cylindrical. For example, for some applications, contraction-facilitating knob 1630 is configured to be actuated by rotation thereof, e.g., about a central longitudinal axis of tubular shaft 1634, such as shown in the drawings. Optionally, for some applications, contraction-facilitating knob 1630 is configured to be actuated by axially sliding thereof with respect to outer housing 1632 (configuration not shown). Contraction-facilitating knob 1630 can be non-electrical, i.e., entirely mechanical, or may optionally comprise electrical components, including, for example, circuity.

0503For some applications, tubular shaft 1634 and contraction-facilitating knob 1630 are in threaded connection with each other, and handle portion 1620 is configured such that actuation of contraction-facilitating knob 1630 rotates tubular shaft 1634, thereby advancing tubular shaft 1634 proximally with respect to outer housing 1632. For some of these applications, contraction-facilitating knob 1630 is configured to be actuated by rotation thereof, e.g., about the central longitudinal axis of tubular shaft 1634, such as shown in the drawings.

0504For some applications, handle portion 1620 further comprises an inner stabilization tube 1680, which (a) extends proximally from and is axially fixed to distal force applicator 1642 and (b) defines therethrough a portion of handle contracting-member-receiving channel 1650. A portion of inner stabilization tube 1680 is disposed within inner-shaft contracting-member-receiving channel 1638; the length of the portion varies with the distance between distal force applicator 1642 and inner shaft 1636. Spring 1646 can be configured to surround a portion of inner stabilization tube 1680 and be free to move axially with respect to the outer surface of inner stabilization tube 1680.

0505For some applications, inner shaft 1636 partially protrudes out of a proximal end 1639 of outer housing 1632, such that a portion of inner shaft 1636 is visible to the user. For these applications, tubular shaft 1634 and inner shaft 1636 together provide a non-electrical mechanical force gauge 1624, in which a relative axial position of tubular shaft 1634 with respect to inner shaft 1636 (i.e., the offset distance D between proximal end 1652 of tubular shaft 1634 and proximal end 1654 of inner shaft 1636) provides a visual indication of a measure of the tension in contracting member 226. Tubular shaft 1634, at least after it begins advancing proximally, can also protrude out of proximal end 1639 of outer housing 1632. For these applications, inner shaft 1636 can be marked with a plurality of fiduciary markers 1626, which are arranged along inner shaft 1636 to indicate the relative axial position of the tubular shaft 1634 with respect to the inner shaft 1636. For example, fiduciary markers 1626 may provide a reading of zero or close to zero when proximal end 1652 of tubular shaft 1634 and proximal end 1654 of inner shaft 1636 are disposed as the initial offset distance D1 therebetween, as shown in <figref idref="f0036">Figs. 22A-B</figref>. (The force applied to spring 1646 at any given level of compression of the spring equals the tension in contracting member 226.)

0506It is noted that force gauge 1624 does not measure the length of contracting member 226 that handle portion 1620 uptakes. (This uptake length is equal to the distance that inner shaft 1636 moves proximally.) As discussed above, an initial portion of the uptake length is sometimes due to proximal movement of inner shaft 1636 while tubular shaft 1634 proximally moves approximately in tandem with inner shaft 1636 before contracting member 226 is tensed. During this optional initial motion, tension in contracting member 226 does not materially increase, even though handle portion 1620 uptakes contracting member 226.

0507More generally, inner shaft 1636 can be considered an axially-movable portion of force gauge 1624. The axially-movable portion of force gauge 1624 is axially-movable with respect to the outer housing 1632 (and, often, with respect to one or more other portions of force gauge 1624, which themselves may or may not be axially movable with respect to outer housing 1632).

0508For some applications, inner shaft 1636 does not protrude out of proximal end 1639 of the outer housing 1632, in which case handle portion 1620 does not provide non-electrical mechanical force gauge 1624. Handle portion 1620 may nevertheless still be entirely useful for regulating the tension in contracting member 226, such as is configurations in which handle portion 1620 further comprises tension-limiting locking assembly 1658 for limiting the maximum tension that inner shaft 1636 can apply to contracting member 226, as described hereinbelow.

0509Reference is again made to <figref idref="f0038">Figs. 24A-B</figref> and <figref idref="f0039">25A-B</figref>. Reference is also made to <figref idref="f0040">Figs. 26A-B</figref>, which are schematic illustrations of a portion of outer housing 1632 and tubular shaft 1634, in accordance with some applications. For clarity of illustration, inner shaft 1636 is not shown. For some applications, handle portion 1620 further comprises a tension-limiting locking assembly 1658, which is configured to axially lock inner shaft 1636 with respect to outer housing 1632 when handle portion 1620 increases the tension in contracting member 226 to a predetermined threshold level, thereby limiting a maximum tension that inner shaft 1636 can apply to contracting member 226. Tension-limiting locking assembly 1658 can be configured to axially lock inner shaft 1636 with respect to outer housing 1632 when tubular shaft 1634 is disposed at a predetermined relative axial position with respect to inner shaft 1636, thereby limiting the maximum tension that inner shaft 1636 can apply to contracting member 226. Tension-limiting locking assembly 1658 can also be configured to axially lock tubular shaft 1634 with respect to outer housing 1632 when tubular shaft 1634 is disposed at a predetermined relative axial position with respect to inner shaft 1636.

0510For some applications, tension-limiting locking assembly 1658 comprises a detent 1660, which is arranged to axially lock inner shaft 1636 with respect to outer housing 1632 when tubular shaft 1634 is disposed at the predetermined relative axial position with respect to inner shaft 1636, such as shown in <figref idref="f0039">Figs. 25A-B</figref>, thereby limiting the maximum tension that inner shaft 1636 can apply to contracting member 226.

0511As shown in the transition between <figref idref="f0038">Figs. 24A-B</figref> and <figref idref="f0039">25A-B</figref>, as spring 1646 becomes more compressed, distal force applicator 1642 moves axially closer to inner shaft 1636, such that tubular shaft 1634 moves proximally with respect to inner shaft 1636. As a result, the offset distance between proximal end 1652 of tubular shaft 1634 and proximal end 1654 of inner shaft 1636 decreases to a maximum-tensed offset distance D3 (which may optionally be zero or close to zero, as illustrated), which is less than the tensed offset distance D2, and equal to the above-mentioned predetermined relative axial position of tubular shaft 1634 with respect to inner shaft 1636. Often, but not necessarily, a relatively small portion of inner shaft 1636 still protrudes from proximal end 1652 of tubular shaft 1634, particularly in configurations in which handle portion 1620 provides non-electrical mechanical force gauge 1624, as described above.

0512For applications in which the implant comprises implantable annuloplasty structure 222, which comprises flexible sleeve 26, sleeve 26 of annuloplasty structure 222 coupled to annulus 240 can be in a tense, contracted state.

0513Tension-limiting locking assembly 1658 optionally obviates the need for non-electrical mechanical force gauge 1624, described hereinabove. In addition, for applications in which force gauge 1624 is provided, tension-limiting locking assembly 1658 obviates the need for the user to repeatedly check the reading of force gauge 1624, thereby allowing the user to focus attention on other aspects of the procedure, such as fluoroscopy images. Often, the predetermined relative axial position of tubular shaft 1634 with respect to inner shaft 1636 has the effect of setting a predetermined maximum tension that can be applied to contracting member 226 using contracting-member-uptake tool 1600.

0514It is noted that tension-limiting locking assembly 1658 often does not axially lock inner shaft 1636 directly in response to the length of contracting member 226 that handle portion 1620 uptakes. (This uptake length is equal to the distance that inner shaft 1636 moves proximally.) In addition, tension-limiting locking assembly 1658 often does not axially lock inner shaft 1636 directly in response to relative axial movement between inner shaft 1636 and outer housing 1632, or directly in response to relative axial movement between tubular shaft 1634 and outer housing 1632. As discussed above, an initial portion of the uptake length is sometimes due to proximal movement of inner shaft 1636 while tubular shaft 1634 proximally moves approximately in tandem with inner shaft 1636 before contracting member 226 is tensed. Since tension-limiting locking assembly 1658 is often configured to axially lock inner shaft 1636 with respect to outer housing 1632 when tubular shaft 1634 is disposed at a predetermined relative axial position with respect to inner shaft 1636, tension-limiting locking assembly 1658 is not affected or triggered by any movement of inner shaft 1636 and tubular shaft 1634 in tandem with each other.

0515For some applications, detent 1660 is coupled in axial fixation with inner shaft 1636, and is configured to move radially outward so as to engage outer housing 1632 in order to axially lock inner shaft 1636 with respect to outer housing 1632, such as shown in <figref idref="f0038">Figs. 24A-B</figref>. For example, a detent-spring 1684 can be provided that applies a radiallyoutwardly-directed force to detent 1660. Handle portion 1620 is configured such that when tubular shaft 1634 is not disposed at the predetermined relative axial position with respect to inner shaft 1636, such as shown in <figref idref="f0036 f0037">Figs. 22A-23B</figref>, an element of handle portion 1620 prevents the radially-outward motion of detent 1660, for example as described below. As used in the present application, including in the claims, "radially outward" means in a direction farther from a central longitudinal axis of outer housing 1632, and "radially inward" means in the opposite direction closer to the central longitudinal axis.

0516For some applications, tension-limiting locking assembly 1658 further comprises a plurality of indentations 1662 that outer housing 1632 is shaped so as to define. Detent 1660 is engageable with indentations 1662 to axially lock inner shaft 1636 with respect to outer housing 1632. Handle portion 1620 is arranged such that the particular one of indentations 1662 with which detent 1660 engages depends upon a relative axial position of inner shaft 1636 with respect to outer housing 1632 when tubular shaft 1634 is disposed at the predetermined relative axial position with respect to inner shaft 1636. In this arrangement, even though the relative axial position of tubular shaft 1634 with respect to inner shaft 1636 at which detent 1660 axially locks inner shaft 1636 with respect to outer housing 1632 is predetermined, the relative positions of tubular shaft 1634 and inner shaft 1636 with respect outer housing 1632 can vary to accommodate differing initial levels of slack in contracting member 226.

0517For some applications, wherein proximal longitudinal portion 1637 of tubular shaft 1634 is shaped so as to define an elongate opening 1664 through which detent 1660 passes when detent 1660 axially locks inner shaft 1636 with respect to outer housing 1632. For some of these applications, tubular shaft 1634 comprises one or more tracks 1666 that run alongside a longitudinal portion of elongate opening 1664 and are arranged to: <ul id="ul0006" list-style="bullet"><li>prevent detent 1660 from axially locking inner shaft 1636 with respect to outer housing 1632 when tubular shaft 1634 is disposed distally to the predetermined relative axial position with respect to inner shaft 1636 (by blocking the radially-outward motion of detent 1660), and</li><li>allow detent 1660 to axially lock inner shaft 1636 when tubular shaft 1634 is disposed at the predetermined relative axial position with respect to inner shaft 1636 (by allowing the radially-outward motion of detent 1660).</li></ul>

0518A portion of the one or more tracks 1666 that prevents detent 1660 from axially locking inner shaft 1636 with respect to outer housing 1632 can be disposed radially inward of a portion of the one or more tracks 1666 that allows detent 1660 to axially lock inner shaft 1636.

0519For some of these applications, proximal longitudinal portion 1637 of tubular shaft 1634 comprises one or more detent supports 1688, which are fixed to detent 1660 and are configured to axially slide along the one or more tracks 1666. When tubular shaft 1634 is disposed distally to the predetermined relative axial position, the one or more tracks 1666 prevent radially-outward motion of the one or more detent supports 1688, thereby preventing the radially-outward motion of detent 1660. For some applications, proximal longitudinal portion 1637 of tubular shaft 1634 comprises one or more detent support posts 1690, which stabilize the one or more detent supports 1688 during radial motion thereof; the one or more detent supports 1688 can slide radially with respect to the one or more detent support posts 1690.

0520For some of these applications, the one or more tracks 1666 are shaped so as to define one or more respective sloping portions 1668. After detent 1660 axially locks inner shaft 1636 with respect to outer housing 1632 when tubular shaft 1634 is disposed at the predetermined relative axial position with respect to inner shaft 1636, subsequent distally-directed motion of tubular shaft 1634 and corresponding distally-directed motion of the one or more tracks 1666 with respect to inner shaft 1636 disengages detent 1660 from outer housing 1632. For example, this disengagement can be caused by the one or more sloping portions 1668 sliding the one or more detent supports 1688 radially inward and onto the portion of the one or more tracks 1665 that are disposed radially inward. The distally-directed motion of tubular shaft 1634 can be caused by actuation of contraction-facilitating knob 1630 in the opposite direction of actuation for the proximally-directed motion described hereinabove. This allows the user to reduce the tension in contracting member 226 if necessary during the procedure, even if the level of tension was high enough to trigger the tension-limiting locking of detent 1660. Of course, if necessary the user can also reduce the tension in contracting member 226 even before the tension-limiting locking of detent 1660.

0521For some applications, once the desired level of tension in contracting member 226 is achieved (by monitoring force gauge 1624, by detent 1660 limiting the maximum tension, and/or, for example, by monitoring the extent of regurgitation of the valve under echocardiographic and/or fluoroscopic guidance), contracting-member-uptake tool 1600 locks contracting member 226 so as to maintain a degree of tension in contracting member 226 in order to maintain contracting member 226 (and, optionally, structure 222, if provided) in a contracted state.

0522For some applications, as perhaps can best be seen in the blow-up in <figref idref="f0039">Fig. 25B</figref>, detent 1660 and/or indentations 1662 are slightly angled (e.g., between 1 and 45 degrees, such as between 1 and 30 degrees, e.g., between 1 and 15 degrees, such as about 5 degrees) with respect to a direction perpendicular to the central longitudinal axis of handle portion 1620, such that detent 1660 faces slightly in a proximal direction and/or the openings of indentations 1662 face slightly in a distal direction. Because detent 1660 moves proximally immediately before engaging one of indentations 1662, this angling eases the catching and engagement of the detent with indentation 1662, and can also ease disengagement if necessary, as discussed above. Alternatively, detent 1660 and/or indentations 1662 are not angled and are perpendicular to the central longitudinal axis of handle portion 1620.

0523Reference is again made to <figref idref="f0035">Figs. 21A-B</figref>. For some applications, spring 1646 is preloaded when proximal end 1652 of tubular shaft 1634 and proximal end 1654 of inner shaft 1636 are disposed at the initial offset distance D1 therebetween. Often, handle portion 1620 is configured to maintain this preload before use of handle portion 1620, by preventing proximal advancement of inner shaft 1636 with respect to tubular shaft 1634 beyond a predetermined maximum distance. For example, a proximal end of elongate opening 1664 (shown, for example, in <figref idref="f0036">Fig. 22B</figref>) may block proximal advancement of an element of tension-limiting locking assembly 1658 (e.g., one or more of the detent support posts 1690 or a proximal portion of the one or more detent supports 1688, labeled in <figref idref="f0040">Figs. 26A</figref>). Setting of the preload is described immediately hereinbelow.

0524Reference is again made to <figref idref="f0035">Fig. 21B</figref>. For some applications, a radially-inward surface of tubular shaft 1634 near a distal end thereof is shaped so as to define a thread 1682, and a radially-outward surface of distal force applicator 1642 is shaped so as to define a corresponding thread 1686. The threads allow the adjustment of the precise axial location of distal force applicator 1642 with respect to tubular shaft 1634 during a calibration procedure during manufacture of handle portion 1620, by rotation of distal force applicator 1642 with respect to tubular shaft 1634. For example, this rotation can be readily performed before insertion into outer housing 1632 of tubular shaft 1634, inner shaft 1636, distal force applicator 1642, spring 1646, and the other elements fixed to inner shaft 1636. During use of handle portion 1620 during a medical procedure, as described hereinabove, distal force applicator 1642 is rotationally fixed, and thus axially fixed, with respect to tubular shaft 1634.

0525For some applications, the adjustment of the axial location of distal force applicator 1642 with respect to tubular shaft 1634 during the calibration procedure adjusts the preload in spring 1646 (by compression of the spring) to set a desired level of maximum tension that inner shaft 1636 can apply to contracting member 226. For example, a distally-directed force can be applied to proximal end 1654 of inner shaft 1636 until the offset distance between proximal end 1652 of tubular shaft 1634 and proximal end 1654 of inner shaft 1636 decreases to the maximum-tensed offset distance D3 (at which tension-limiting locking assembly 1658 is triggered during subsequent use). This applied distally-directed force can be measured with a force gauge, and the axial location of distal force applicator 1642 with respect to tubular shaft 1634 may be adjusted until the applied distally-directed force equals the desired level of maximum tension that inner shaft 1636 can apply to contracting member 226 before tension-limiting locking assembly 1658 is triggered during subsequent use. Upon removal of this calibration distally-directed force, spring 1646 will elongate until further advancement of inner shaft 1636 is blocked, as described above, and spring 1646 will have a desired level of preload.

0526Reference is again made to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026 f0027 f0028 f0029 f0030 f0031 f0032 f0033 f0034 f0035 f0036 f0037 f0038 f0039 f0040">Figs. 1-26B</figref>. Systems 10, 510, 700, 800, 900, 1000, 1100, 1200, 1300, 1350, 1400, 1480, and 1500 and methods for repairing a dilated annulus of the patient can be used to treat any cardiac valve of the patient, e.g., the aortic valve, the pulmonary valve, the mitral valve, and the tricuspid valve. Further, systems described herein for treatment of valves can be used to treat other annular muscles within the body of the patient. For example, the systems described herein can be used in order to treat a sphincter muscle within a stomach of the patient.

0527Reference is again made to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026 f0027 f0028 f0029 f0030 f0031 f0032 f0033 f0034 f0035 f0036 f0037 f0038 f0039 f0040">Figs. 1-26B</figref>. Systems 10, 510, 700, 800, 900, 1000, 1100, 1200, 1300, 1350, 1400, 1480, and 1500 can be anchored to tissue of the annulus using any of the anchoring devices described in <patcit id="pcit0017" dnum="US20150272734"><text>US Patent Application Publication 2015/0272734 to Sheps et al.</text></patcit>, including the anchor driver and the deployment manipulator.

0528Reference is again made to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026 f0027 f0028 f0029 f0030 f0031 f0032 f0033 f0034 f0035 f0036 f0037 f0038 f0039 f0040">Figs. 1-26B</figref>. Systems 10, 510, 700, 800, 900, 1000, 1100, 1200, 1300, 1350, 1400, 1480, and 1500 and methods described hereinabove can be used on any suitable tissue of the patient (e.g., stomach tissue, urinary tract, and prostate tissue).

0529Reference is now made to <figref idref="f0001 f0002 f0003 f0004 f0005 f0006 f0007 f0008 f0009 f0010 f0011 f0012 f0013 f0014 f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026 f0027 f0028 f0029 f0030 f0031 f0032 f0033 f0034 f0035 f0036 f0037 f0038 f0039 f0040">Figs. 1-26B</figref>. Tools described herein can be used to deploy, anchor, and adjust a perimeter of any annuloplasty structure, e.g., a full (or closed) annuloplasty structure or a partial (or open) annuloplasty structure. Any tool described herein can be coupled to the annuloplasty structure using any coupling described herein with reference to <figref idref="f0015 f0016 f0017 f0018 f0019 f0020 f0021 f0022 f0023 f0024 f0025 f0026 f0027 f0028 f0029 f0030 f0031 f0032 f0033 f0034 f0035 f0036 f0037 f0038 f0039 f0040">Figs. 7A-26B</figref>. For example, any annuloplasty structure described herein can comprise housing 930 having female coupling 927 and the tools described herein can comprise male coupling 925 tools as described hereinabove with reference to <figref idref="f0025">Figs. 12</figref>, <figref idref="f0026">13</figref>, and <figref idref="f0028">15</figref>. The annuloplasty structures described herein can comprise elements and structures as described in <patcit id="pcit0018" dnum="WO10073246A"><text>PCT Publication WO 10/073246 to Cabiri et al.</text></patcit> which is incorporated herein by reference.

0530Additionally, applications described in one or more of the following can be used with the various embodiments in this disclosure: <ul id="ul0007" list-style="bullet"><li><patcit id="pcit0019" dnum="US43529109"><text>US Patent Application 12/435,291 to Maisano et al., entitled, "Adjustable repair chords and spool mechanism therefor," filed on May 4, 2009</text></patcit>, which issued as <patcit id="pcit0020" dnum="US8147542B"><text>US Patent 8,147,542</text></patcit>;</li><li><patcit id="pcit0021" dnum="US43710309"><text>US Patent Application 12/437,103 to Zipory et al., entitled, "Annuloplasty ring with intra-ring anchoring," filed on May 7, 2009</text></patcit>, which issued as <patcit id="pcit0022" dnum="US8715342B"><text>US Patent 8,715,342</text></patcit>;</li><li><patcit id="pcit0023" dnum="US54899109"><text>US Patent Application 12/548,991 to Maisano et al., entitled, "Implantation of repair chords in the heart," filed on August 27, 2009</text></patcit>, which issued as <patcit id="pcit0024" dnum="US8808368B"><text>US Patent 8,808,368</text></patcit>;</li><li>PCT Patent Application <patcit id="pcit0025" dnum="IL2009001209W"><text>PCT/IL2009/001209 to Cabiri et al., entitled, "Adjustable annuloplasty devices and mechanisms therefor," filed on December 22, 2009</text></patcit>, which published as <patcit id="pcit0026" dnum="WO10073246A"><text>PCT Publication WO 10/073246</text></patcit>;</li><li>PCT Patent Application <patcit id="pcit0027" dnum="IL2010000357W"><text>PCT/IL2010/000357 to Maisano et al., entitled, "Implantation of repair chords in the heart," filed on May 4, 2010</text></patcit>, which published as <patcit id="pcit0028" dnum="WO10128502A"><text>WO 10/128502</text></patcit>;</li><li>PCT Patent Application<patcit id="pcit0029" dnum="IL2010000358W"><text> PCT/IL2010/000358 to Zipory et al., entitled, "Deployment techniques for annuloplasty ring and over-wire rotation tool," filed on May 4, 2010</text></patcit>, which published as <patcit id="pcit0030" dnum="WO10128503A"><text>WO 10/128503</text></patcit>;</li><li><patcit id="pcit0031" dnum="US20140309661"><text>US Patent Application Publication 2014/0309661 to Sheps et al.</text></patcit>; and/or</li><li><patcit id="pcit0032" dnum="US20150272734"><text>US Patent Application Publication 2015/0272734 to Sheps et al.</text></patcit></li></ul>

0531All of these applications are incorporated herein by reference. Techniques described herein can be practiced in combination with techniques described in one or more of these applications. Additionally, any and all of the methods, techniques, steps, etc. described herein can be performed on a living animal or in a simulation/simulated method (e.g., on a cadaver, cadaver heart, simulator with a simulated heart, tissue, etc., anthropomorphic ghost, etc.)

0532The present invention is not limited to what has been particularly shown and described hereinabove. Rather, the scope of the present invention includes both combinations and subcombinations of the various features described hereinabove, as well as variations and modifications thereof that are not in the prior art, which would occur to persons skilled in the art upon reading the foregoing description.

0533The invention further comprises the following embodiments: <ul id="ul0008" list-style="none"><li>1. Apparatus, comprising: <ul id="ul0009" list-style="none" compact="compact"><li>an implantable annuloplasty structure comprising: <ul id="ul0010" list-style="none" compact="compact"><li>a primary body portion; and</li><li>a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary portion of the annuloplasty structure; and</li></ul></li><li>a contracting-member-uptake tool comprising: <ul id="ul0011" list-style="none" compact="compact"><li>a primary tube terminating at a distal end portion of the contracting-member-uptake tool, the distal end portion of the contracting-member-uptake tool having a distal tip;</li><li>a secondary tube disposed alongside the primary tube, the secondary tube having a secondary-tube lumen being configured for passage therethrough of the contracting member; and</li><li>a contracting-member-snare comprising a distal snare portion and an elongate flexible body portion coupled to the distal snare portion, the distal snare portion being configured to ensnare a portion of the contracting member and being sized to pass through the secondary-tube lumen of the secondary tube in order to pull the second portion of the contracting member through a length of the secondary tube.</li></ul></li></ul></li><li>2. The apparatus according to embodiment 1, wherein the distal snare portion is configured to pull the second portion of the contracting member through the distal tip of the contracting-member-uptake tool and subsequently through the length of the secondary tube.</li><li>3. The apparatus according to any one of embodiments 1 to 2, wherein the contracting-member-snare comprises a wire having a diameter of 0.2-0.25 mm.</li><li>4. The apparatus according to any one of embodiments 1 to 3, wherein the primary tube is flexible, and wherein the secondary tube is flexible.</li><li>5. The apparatus according to any one of embodiments 1 to 4, wherein the annuloplasty structure defines a partial annuloplasty ring structure.</li><li>6. The apparatus according to any one of embodiments 1 to 5, wherein the secondary tube is shaped so as to define a longitudinal slit.</li><li>7. The apparatus according to any one of embodiments 1 to 6, wherein the contracting-member-uptake tool comprises a handle portion and wherein the first and second tubes are connected to the handle portion.</li><li>8. The apparatus according to embodiment 7, wherein the handle portion comprises: <ul id="ul0012" list-style="none" compact="compact"><li>a contracting-member-uptake device configured to uptake successive portions of the contracting member; and</li><li>a tension meter configured to measure a degree of tension of the contracting member.</li></ul></li><li>9. The apparatus according to embodiment 8, wherein the contracting-member-uptake device is actuatable to increase tension of the contracting member.</li><li>10. The apparatus according to embodiment 8, wherein the contracting-member-uptake device comprises a knob coupled to a proximal portion of the contracting member, the knob being configured to increase tension of the contracting member by pulling the contracting member proximally.</li><li>11. The apparatus according to embodiment 10, wherein the contracting-member-uptake device comprises a wheel having a groove configured to couple the contracting member to the wheel.</li><li>12. The apparatus according to embodiment 11, wherein the groove is shaped so as to receive a middle portion of the contracting member.</li><li>13. The apparatus according to any one of embodiments 1 to 12, wherein the secondary-tube lumen of the secondary tube is sized so as to maintain coupling between the distal snare portion and the contracting member.</li><li>14. The apparatus according to embodiment 13, wherein the snare portion comprises a flexible loop, and wherein the secondary-tube-lumen is configured to collapse the loop around the contracting member as the elongate flexible body portion is pulled through the secondary-tube-lumen.</li><li>15. The apparatus according to any one of embodiments 1 to 14, wherein at least the distal snare portion of the contracting-member-snare is corrugated to increase friction between the snare portion and the contracting member.</li><li>16. The apparatus according to any one of embodiments 1 to 15, wherein the distal snare portion is configured pull the second portion of the contracting member through an entire length of the secondary tube.</li><li>17. The apparatus according to any one of embodiments 1 to 16, wherein the contracting member-uptake tool comprises: <ul id="ul0013" list-style="none" compact="compact"><li>at least one contracting-member-fastener disposed within the distal end portion of the contracting-member-uptake tool, the contracting-member-fastener comprising a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move; and</li><li>a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state.</li></ul></li><li>18. The apparatus according to embodiment 17, wherein the at least one contracting-member-fastener comprises at least first and second contracting-member-fastener disposed within the distal end portion of the contracting-member-uptake tool.</li><li>19. The apparatus according to embodiment 18, wherein the distal snare portion and the elongate flexible body portion of the contracting-member-snare are sized to pass distally through the contracting-member-fastener in the open state, the snare portion being adapted to capture and pull the contracting member proximally through the contracting-member-fastener and through aligned ports in the distal end portion of the contracting-member-uptake tool.</li><li>20. The apparatus according to embodiment 19, wherein the contracting-member-uptake tool comprises a fastener-ejector movable within the distal end portion of the contracting-member-uptake tool, and wherein movement of the fastener-ejector contacts and converts the contracting-member-fastener from the open state to the closed state to clamp onto the contracting member passed therethrough.</li><li>21. The apparatus according to embodiment 20, wherein the fastener-ejector is coupled to the stop and moves the stop that is removably coupled to the fastener.</li><li>22. The apparatus according to any one of embodiments 20 to 21, wherein the distal end portion of the contracting-member-uptake tool is shaped so as to define a sharp edge, and wherein the contracting member is disposed in proximity to the sharp edge such that movement of the fastener-ejector against the sharp edge severs the contracting member extending through the fastener.</li><li>23. The apparatus according to any one of embodiments 1 to 22, further comprising: <ul id="ul0014" list-style="none" compact="compact"><li>at least one contracting-member-fastener configured to surround the contracting member, the contracting-member-fastener comprising a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move; and</li><li>a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state.</li></ul></li><li>24. The apparatus according to embodiment 23, wherein the tool comprises a moveable cutting element having a sharp edge, and movement of the stop hammers the stop against the moveable cutting element such that movement of the moveable cutting element severs the contracting member extending through the fastener and through the moveable cutting element.</li><li>25. The apparatus according to any one of embodiments 1 to 24, further comprising a lock slidable along the contracting member, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member, wherein: <ul id="ul0015" list-style="none" compact="compact"><li>the lock is shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock,</li><li>the lock defines a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock,</li><li>the lock lumen is configured to surround the contracting member, and</li><li>when the lock is compressed, the slit enables the lock to close around the contracting member and thereby lock the lock to the contracting member.</li></ul></li><li>26. The apparatus according to embodiment 25, wherein the annuloplasty structure is shaped so as to define a recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.</li><li>27. The apparatus according to embodiment 26, wherein the recess is dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.</li><li>28. The apparatus according to embodiment 25, wherein the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion of the lock lumen.</li><li>29. The apparatus according to embodiment 28, wherein the recess is shaped so as to define a proximal portion that is narrower than any other portion of the recess distal to the proximal portion.</li><li>30. The apparatus according to embodiment 25, wherein the lock is disposed within the distal end portion of the contracting-member-uptake tool.</li><li>31. The apparatus according to embodiment 30, wherein when the contracting-member-uptake tool is coupled to the annuloplasty structure, the lock is disposed at least in part within the recess.</li><li>32. The apparatus according to embodiment 30, wherein when the contracting-member-uptake tool is coupled to the annuloplasty structure, the lock is disposed entirely proximally to the recess.</li><li>33. The apparatus according to embodiment 25, wherein the lock is disposed within the distal end portion of the contracting-member-uptake tool.</li><li>34. The apparatus according to embodiment 33, wherein the distal snare portion and the elongate flexible body portion of the contracting-member-snare are sized to pass distally through lock, the snare portion being adapted to capture and pull the contracting member proximally through the lock and through aligned ports in the distal end portion of the contracting-member-uptake tool.</li><li>35. Apparatus, comprising: <ul id="ul0016" list-style="none" compact="compact"><li>an implantable annuloplasty structure comprising: <ul id="ul0017" list-style="none" compact="compact"><li>a primary body portion; and</li><li>a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty ring structure, and (2) a second portion extending away from the primary body portion of the annuloplasty ring structure;</li></ul></li><li>a housing configured to be positionable against the primary body portion of the annuloplasty ring structure;</li><li>a contracting-member-fastener disposed at least in part within the housing, the contracting-member-fastener comprising a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move;</li><li>a stop removably coupled to the fastener and configured to maintain the contracting-member-fastener in the open state; and</li><li>a fastener-ejector engageable with the stop such that movement of the fastener-ejector moves the stop removably coupled to the fastener and converts the clamping structure from the open state to the closed state to clamp onto the contracting member passed therethrough.</li></ul></li><li>36. The apparatus according to embodiment 35, wherein the fastener-ejector is shaped such that movement thereof facilitates severing of the contracting member extending through the fastener.</li><li>37. The apparatus according to embodiment 35, wherein the fastener comprises a deformable element having a slanted state and a straight state, wherein the stop is configured to maintain the fastener in the slanted state, and wherein, upon removal of the stop, the fastener is configured to transition to the straight state and claim the contracting member between the fastener and a surface of the housing.</li><li>38. The apparatus according to embodiment 37, wherein the fastener is shaped so as to define a plurality of teeth configured to increase friction between the contracting member and the fastener.</li><li>39. A system, comprising: <ul id="ul0018" list-style="none" compact="compact"><li>an implantable annuloplasty structure comprising: <ul id="ul0019" list-style="none" compact="compact"><li>a primary body portion; and</li><li>a contracting member extending at least partially along a longitudinal length of the primary body portion of the annuloplasty structure; and</li></ul></li><li>a contracting-member-uptake tool comprising: <ul id="ul0020" list-style="none" compact="compact"><li>a tube having a lumen configured for passage therethrough of the contracting member; and</li><li>a contracting-member-snare comprising a distal snare portion and an elongate flexible body portion coupled to the distal snare portion, the distal snare portion being configured to ensnare a portion of the contracting member and pull it into the lumen.</li></ul></li></ul></li><li>40. The system according to embodiment 39, wherein the distal snare portion is configured to pull the portion of the contracting member through an entire length of the lumen.</li><li>41. The system according to embodiment 39, wherein the tube is flexible.</li><li>42. The system according to any one of embodiments 39 to 41, wherein the contracting-member-uptake tool comprises a handle portion and wherein the tube is connected to the handle portion.</li><li>43. The system according to embodiment 42, wherein the handle portion comprises: <ul id="ul0021" list-style="none" compact="compact"><li>a contracting-member-uptake device configured to uptake successive portions of the contracting member; and</li><li>a tension meter configured to measure a degree of tension of the contracting member.</li></ul></li><li>44. The system according to embodiment 43, wherein the contracting-member-uptake device is actuatable to increase tension of the contracting member.</li><li>45. The system according to any one of embodiments 43 to 44, wherein the contracting-member-uptake device comprises a wheel having a groove configured to couple the contracting member to the wheel.</li><li>46. The system according to embodiment 45, wherein the groove is shaped so as to receive a middle portion of the contracting member.</li><li>47. The system according to any one of embodiments 39 to 46, wherein the lumen of the tube is sized so as to maintain coupling between the distal snare portion and the contracting member.</li><li>48. The system according to any one of embodiments 39 to 47, wherein the distal snare portion comprises a flexible loop, and wherein the lumen is configured to collapse the loop around the contracting member as the portion of the contracting member is pulled through the lumen.</li><li>49. The system according to any one of embodiments 39 to 48, wherein at least the distal snare portion of the contracting-member-snare is corrugated to increase friction between the snare portion and the contracting member.</li><li>50. The system according to any one of embodiments 39 to 49, wherein the distal end portion of the contracting-member-uptake tool is shaped so as to define a sharp edge, and wherein the contracting member-uptake tool is configured to dispose the contracting member in proximity to the sharp edge such that the sharp edge can sever the contracting member.</li><li>51. The system according to any one of embodiments 39 to 50, wherein the contracting member-uptake tool comprises: <ul id="ul0022" list-style="none" compact="compact"><li>a contracting-member-fastener disposed within the distal end portion of the contracting-member-uptake tool, the contracting-member-fastener comprising a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move; and</li><li>a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state.</li></ul></li><li>52. The system according to embodiment 51, wherein the distal snare portion and the portion of the contracting-member are sized to pass distally through the contracting-member-fastener in its open state, the distal snare portion being adapted to capture and pull the portion of the contracting member proximally through the contracting-member-fastener and through aligned ports in the distal end portion of the contracting-member-uptake tool.</li><li>53. The system according to embodiment 52, wherein the contracting-member-uptake tool comprises a fastener-ejector movable within the distal end portion of the contracting-member-uptake tool, and wherein movement of the fastener-ejector contacts and can convert the contracting-member-fastener from its open state to its closed state to clamp onto the contracting member when passed therethrough.</li><li>54. The system according to embodiment 53, wherein the fastener-ejector is coupled to the stop and moves the stop that is removably coupled to the fastener.</li><li>55. Apparatus, comprising: <ul id="ul0023" list-style="none" compact="compact"><li>an implantable annuloplasty structure comprising: <ul id="ul0024" list-style="none" compact="compact"><li>a primary body portion having a lateral wall; and</li><li>a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary body portion of the annuloplasty structure, the contracting member being configured to adjust a perimeter of the annuloplasty structure,</li><li>the primary body portion of the annuloplasty structure being shaped to define a recess having a recess axis, the recess extending from an opening in a first surface of the lateral wall of the primary body portion toward an opposite second surface of the lateral wall of the primary body portion, the lateral wall of the primary body portion extending away from the recess along a longitudinal axis that is at a non-zero angle with respect to the recess axis, the contracting member extending through the recess and away from the primary body portion of the annuloplasty structure via the recess; and</li></ul></li><li>a lock slidable along the contracting member and toward the recess, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member, the recess being shaped so as to facilitate fixed coupling of the lock to the contracting member.</li></ul></li><li>56. The apparatus according to embodiment 55, wherein the lock is disposable at least in part within the recess.</li><li>57. The apparatus according to embodiment 55, wherein the annuloplasty structure comprises a partial annuloplasty ring structure.</li><li>58. The apparatus according to any one of embodiments 55 to 57, wherein the lock is configured to lock the contracting member when the lock is moved at least in part within the recess.</li><li>59. The apparatus according to any one of embodiments 55 to 57, wherein the lock is configured to fit entirely within the recess.</li><li>60. The apparatus according to any one of embodiments 55 to 59, wherein: <ul id="ul0025" list-style="none" compact="compact"><li>the primary body portion comprises a housing,</li><li>the housing defines at least a portion of the lateral wall, and</li><li>the housing defines the recess.</li></ul></li><li>61. The apparatus according to any one of embodiments 55 to 60, wherein the lock is shaped so as to define a lock-threaded-portion, and wherein the annuloplasty structure is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.</li><li>62. The apparatus according to any one of embodiments 55 to 61, wherein the recess defines a recess lumen extending along the recess axis.</li><li>63. The apparatus according to embodiment 62, wherein the recess axis is disposed at the non-zero angle.</li><li>64. The apparatus according to any one of embodiments 55 to 63, wherein: <ul id="ul0026" list-style="none" compact="compact"><li>the lock is shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock,</li><li>the lock defines a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock,</li><li>the lock lumen is configured to surround the contracting member, and</li><li>when the lock is disposed within the recess, the slit enables the lock to close around the contracting member and thereby lock the lock to the contracting member.</li></ul></li><li>65. The apparatus according to embodiment 64, wherein the recess is dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.</li><li>66. The apparatus according to embodiment 64, wherein at least one of the slit and the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion thereof.</li><li>67. The apparatus according to embodiment 64, wherein the recess is shaped so as to define a proximal-most portion that is narrower than any other portion of the recess distal to the proximal-most portion.</li><li>68. The apparatus according to any one of embodiments 55 to 67, wherein the annuloplasty structure comprises a housing, and wherein the housing is shaped so as to define the recess, the recess having a recess axis.</li><li>69. The apparatus according to embodiment 68, wherein the lock is shaped so as to define a lock-threaded-portion, and wherein the housing is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.</li><li>70. The apparatus according to embodiment 68, wherein the housing is shaped so as to define a contracting-member lumen that is disposed at a non-zero angle with respect to the recess axis.</li><li>71. The apparatus according to embodiment 70, wherein the housing is shaped so as to provide a contracting-member-lumen wall which is disposed along the contracting-member lumen, and wherein when the lock is disposed within the recess, a distal end of the lock is configured to pinch a first portion of the contracting member against the contracting-member-lumen wall in order to lock the contracting member at least a first pinching point.</li><li>72. The apparatus according to embodiment 71, wherein: <ul id="ul0027" list-style="none" compact="compact"><li>the recess is shaped so as to define a recess-distal-tapered-portion,</li><li>the lock is shaped so as to define: <ul id="ul0028" list-style="none" compact="compact"><li>a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock, and</li><li>a lock-distal-tapered-portion,</li></ul></li><li>the lock lumen is configured to surround the contracting member, and</li><li>when the lock is disposed within the recess, the recess-distal-tapered-portion is configured to compress the lock-distal-tapered-portion which, in turn, is configured to pinch a second portion of the contracting member within the lock lumen at the recess-distal-tapered-portion in order to lock the contracting member at least a second pinching point.</li></ul></li><li>73. The apparatus according to any one of embodiments 55 to 72, further comprising a delivery tool, the delivery tool and the contracting member being slidable with respect to each other, the delivery tool being configured to deliver the annuloplasty structure to an annulus of a heart of a patient.</li><li>74. The apparatus according to embodiment 73, wherein the delivery tool comprises a knob coupled to a proximal portion of the contracting member, the knob being configured to increase tension of the contracting member by pulling the contracting member proximally.</li><li>75. The apparatus according to embodiment 73, wherein when the delivery tool is coupled to the annuloplasty structure, a portion of the contracting member is disposed within a lumen of the delivery tool and the lock surrounds a part of the contracting member.</li><li>76. The apparatus according to embodiment 75, wherein when the delivery tool is coupled to the annuloplasty structure, the lock is disposed at least in part within the recess.</li><li>77. The apparatus according to embodiment 75, wherein the delivery tool comprises a lock-ejector movable within a distal end portion of the delivery tool, and wherein movement of the lock-ejector contacts and converts the lock from an open state to a closed state to clamp onto the contracting member passed therethrough.</li><li>78. The apparatus according to embodiment 77, wherein the distal end portion of the delivery tool is shaped so as to define a sharp edge, and wherein the contracting member is disposed in proximity to the sharp edge such that movement of the lock-ejector against the sharp edge severs the contracting member extending through the lock.</li><li>79. Apparatus, comprising: <ul id="ul0029" list-style="none" compact="compact"><li>an implantable annuloplasty structure comprising: <ul id="ul0030" list-style="none" compact="compact"><li>a primary body portion; and</li><li>a contracting member having a (1) first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and a (2) second portion extending away from the primary portion of the annuloplasty structure; and</li></ul></li><li>a lock slidable along the contracting member, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member, wherein: <ul id="ul0031" list-style="none" compact="compact"><li>the lock is shaped so as to define a slit which extends from a proximal surface of the lock toward a distal surface of the lock,</li><li>the lock defines a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock,</li><li>the lock lumen is configured to surround the contracting member, and</li><li>when the lock is compressed, the slit enables the lock to close around the contracting member and thereby lock the lock to the contracting member.</li></ul></li></ul></li><li>80. The apparatus according to embodiment 79, wherein the annuloplasty structure comprises a partial annuloplasty ring structure.</li><li>81. The apparatus according to any one of embodiments 79 to 80, wherein the annuloplasty structure is shaped so as to define a recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess.</li><li>82. The apparatus according to embodiment 81, wherein the lock is disposable at least in part within the recess.</li><li>83. The apparatus according to embodiment 81, wherein at least one of the slit and the lock lumen is shaped so as to define a distal portion that is wider than a proximal portion thereof.</li><li>84. The apparatus according to embodiment 81, wherein the recess is shaped so as to define a proximal portion that is narrower than any other portion of the recess distal to the proximal portion.</li><li>85. The apparatus according to embodiment 81, wherein the lock is shaped so as to define a lock-threaded-portion, and wherein the annuloplasty structure is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.</li><li>86. The apparatus according to embodiment 81, wherein the annuloplasty structure comprises a housing, and wherein the housing is shaped so as to define the recess, the recess having a recess axis.</li><li>87. The apparatus according to embodiment 86, wherein the lock is shaped so as to define a lock-threaded-portion, and wherein the housing is shaped so as to define an annuloplasty-structure-threaded-portion configured to engage with the lock-threaded-portion.</li><li>88. The apparatus according to embodiment 86, wherein the housing is shaped so as to define a contracting-member lumen that is disposed at a non-zero angle with respect to the recess axis.</li><li>89. The apparatus according to embodiment 88, wherein the housing is shaped so as to provide a contracting-member-lumen wall which is disposed along the contracting-member lumen, and wherein when the lock is disposed within the recess, a distal end of the lock is configured to pinch a first portion of the contracting member against the contracting-member-lumen wall in order to lock the contracting member at least a first pinching point.</li><li>90. The apparatus according to embodiment 89, wherein: <ul id="ul0032" list-style="none" compact="compact"><li>the recess is shaped so as to define a recess-distal-tapered-portion,</li><li>the lock is shaped so as to define: <ul id="ul0033" list-style="none" compact="compact"><li>a lock lumen of the lock extending from a proximal opening in the lock toward a distal opening in the lock, and</li><li>a lock-distal-tapered-portion,</li></ul></li><li>the lock lumen is configured to surround the contracting member, and</li><li>when the lock is disposed within the recess, the recess-distal-tapered-portion is configured to compress the lock-distal-tapered-portion which, in turn, is configured to pinch a second portion of the contracting member within the lock lumen at the recess-distal-tapered-portion in order to lock the contracting member at least a second pinching point.</li></ul></li><li>91. The apparatus according to any one of embodiments 79 to 90, further comprising a delivery tool, the delivery tool and the contracting member being slidable with respect to each other, the delivery tool being configured to deliver the annuloplasty structure to an annulus of a heart of a patient.</li><li>92. The apparatus according to embodiment 91, wherein the delivery tool comprises a knob coupled to a proximal portion of the contracting member, the knob being configured to increase tension of the contracting member by pulling the contracting member proximally.</li><li>93. The apparatus according to embodiment 92, wherein the knob is fixedly coupled to the proximal portion of the contracting member.</li><li>94. The apparatus according to embodiment 91, wherein when the delivery tool is coupled to the annuloplasty structure, a portion of the contracting member is disposed within a lumen of the delivery tool and the lock surrounds a part of the contracting member.</li><li>95. The apparatus according to embodiment 94, <ul id="ul0034" list-style="none" compact="compact"><li>wherein the annuloplasty structure is shaped so as to define the recess dimensioned so as to compress the lock when the lock is disposed at least in part within the recess, and</li><li>wherein when the delivery tool is coupled to the annuloplasty structure, the lock is disposed at least in part within the recess.</li></ul></li><li>96. The apparatus according to embodiment 94, wherein the delivery tool comprises a lock-ejector movable within a distal end portion of the delivery tool, and wherein movement of the lock-ejector contacts and converts the lock from an open state to a closed state to clamp onto the contracting member passed therethrough.</li><li>97. The apparatus according to any one of embodiments 91 to 96, wherein the distal end portion of the delivery tool is shaped so as to define a sharp edge, and wherein the contracting member is disposed in proximity to the sharp edge such that movement of the lock-ejector against the sharp edge severs the contracting member extending through the lock.</li><li>98. Apparatus, comprising: <ul id="ul0035" list-style="none" compact="compact"><li>an implantable annuloplasty structure comprising: <ul id="ul0036" list-style="none" compact="compact"><li>a primary body portion; and</li><li>a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary portion of the annuloplasty structure;</li></ul></li><li>at least one contracting-member-fastener configured to surround the contracting member, the contracting-member-fastener comprising a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move;</li><li>a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state; and</li><li>a contracting-member-severing tool comprising: <ul id="ul0037" list-style="none" compact="compact"><li>a static cutting element having a first cutting surface; and</li><li>a dynamic cutting element having a second cutting surface that opposes the first cutting surface; and</li><li>one or more graspers configured to pull the stop proximally and remove the stop from the contracting-member-fastener, wherein: <ul id="ul0038" list-style="none" compact="compact"><li>a portion of the contracting member passes through the static cutting element and through the dynamic cutting element, and</li><li>once pulled proximally, the stop contacts the cutting element and is configured to push against and move the dynamic cutting element with respect to the static cutting element in order to facilitate severing of the contracting member.</li></ul></li></ul></li></ul></li><li>99. The apparatus according to embodiment 98, wherein the first and second cutting surfaces are each concave.</li><li>100. The apparatus according to any one of embodiments 98 to 99, wherein the first and second cutting surfaces are each diagonal.</li><li>101. The apparatus according to any one of embodiments 98 to 100, wherein the tool is arranged such that the tool provides a safety mechanism whereby movement of the dynamic cutting element with respect to the static cutting element is possible only with pushing of the stop against the dynamic cutting element.</li><li>102. The apparatus according to any one of embodiments 98 to 101, further comprising a housing that houses the fastener and the stop, and wherein the tool is coupled to the housing as the graspers grasp the stop.</li><li>103. The apparatus according to embodiment 102, wherein the tool is configured to deliver the housing, the fastener, and the stop to the implantable annuloplasty structure.</li><li>104. The apparatus according to embodiment 102, wherein the implantable annuloplasty structure comprises the housing.</li><li>105. The apparatus according to any one of embodiments 98 to 104, wherein the stop is shaped so as to define an overhang, and wherein the graspers are configured to grip the overhang in order to initially couple the tool to the fastener.</li><li>106. The apparatus according to embodiment 105, further comprising an outer sleeve portion configured to surround the graspers in order to lock the graspers with respect to the overhang.</li><li>107. Apparatus, comprising: <ul id="ul0039" list-style="none" compact="compact"><li>a contracting-member fastener configured to fasten to a contracting member;</li><li>at least one contracting-member-fastener configured to surround the contracting member, the contracting-member-fastener comprising a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move;</li><li>a stop removably coupled to the contracting-member-fastener and configured to maintain the contracting-member-fastener in the open state; and</li><li>a contracting-member-severing tool comprising: <ul id="ul0040" list-style="none" compact="compact"><li>a cutting element configured to cut the contracting member; and</li><li>one or more graspers configured to pull the stop proximally and remove the stop from the contracting-member-fastener,</li><li>wherein once pulled proximally, the stop contacts the cutting element and is configured to push against and move the cutting element in order to facilitate severing of the contracting member by the cutting element.</li></ul></li></ul></li><li>108. The apparatus according to embodiment 107, wherein the tool is arranged such that the tool provides a safety mechanism whereby movement of the cutting element is possible only with pushing of the stop against the cutting element.</li><li>109. The apparatus according to any one of embodiments 107 to 108, further comprising a housing that houses the fastener and the stop, and wherein the tool is coupled to the housing as the graspers grasp the stop.</li><li>110. The apparatus according to embodiment 109, further comprising an implantable annuloplasty structure, wherein the tool is configured to deliver the housing, the fastener, and the stop to the implantable annuloplasty structure.</li><li>111. The apparatus according to embodiment 109, further comprising an implantable annuloplasty structure, wherein the implantable annuloplasty structure comprises the housing.</li><li>112. The apparatus according to any one of embodiments 107 to 111, wherein the stop is shaped so as to define an overhang, and wherein the graspers are configured to grip the overhang in order to initially couple the tool to the fastener.</li><li>113. The apparatus according to embodiment 112, further comprising an outer sleeve portion configured to surround the graspers in order to lock the graspers with respect to the overhang.</li><li>114. Apparatus comprising: <ul id="ul0041" list-style="none" compact="compact"><li>an implant comprising an implantable structure and a flexible elongated contracting member that extends away from the implantable structure; and</li><li>a contracting-member-uptake tool, which comprises a handle portion, which comprises: <ul id="ul0042" list-style="none" compact="compact"><li>an outer housing;</li><li>a tubular shaft disposed at least partially within the outer housing;</li><li>an inner shaft, which (a) is partially disposed within a proximal longitudinal portion of the tubular shaft, such that the inner shaft is axially slidable with respect to the tubular shaft, (b) is shaped so as to define an inner-shaft contracting-member-receiving channel, and (c) comprises a lock, which is configured (i) when in an unlocked state, to allow sliding of the contracting member with respect to the inner-shaft contracting-member-receiving channel, and (ii) when in a locked state, to axially lock the contracting member with respect to the inner shaft;</li><li>a distal force applicator, which (a) is disposed at least partially within a distal longitudinal portion of the tubular shaft, and (b) is shaped so as to define a distal-force-applicator contracting-member-receiving channel, which allows sliding of the contracting member therethrough;</li><li>a spring, which is disposed within the tubular shaft, connecting the distal force applicator and a distal portion of the inner shaft; and</li><li>a contraction-facilitating knob, which is accessible from outside the outer housing,</li></ul></li><li>wherein the handle portion is shaped so as to define a handle contracting-member-receiving channel from a distal end through to a proximal end of the handle portion, wherein the handle contracting-member-receiving channel includes the inner-shaft contracting-member-receiving channel and the distal-force-applicator contracting-member-receiving channel,</li><li>wherein the handle portion is configured such that actuation of the contraction-facilitating knob, when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel and the lock is in the locked state, causes the handle portion to uptake successive portions of the contracting member by: <ul id="ul0043" list-style="none" compact="compact"><li>advancing the tubular shaft proximally with respect to the outer housing,</li><li>which advances the distal force applicator proximally with respect to the outer housing,</li><li>which applies a proximally-directed force to the spring,</li><li>which pushes the inner shaft proximally with respect to the outer housing,</li><li>which proximally pulls the contracting member, and</li><li>wherein the handle portion is configured such that upon the actuation of the contraction-facilitating knob when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel, the lock is in the locked state, and the contracting member is tensed: <ul id="ul0044" list-style="none" compact="compact"><li>the spring pushes the inner shaft proximally with respect to the outer housing to a lesser extent than the tubular shaft proximally advances with respect to the outer housing, and</li><li>proximal pulling of the contracting member by the inner shaft increases tension in the contracting member.</li></ul></li></ul></li></ul></li><li>115. The apparatus according to embodiment 114, wherein the contraction-facilitating knob is configured to be actuated by rotation thereof.</li><li>116. The apparatus according to any one of embodiments 114, <ul id="ul0045" list-style="none" compact="compact"><li>wherein the tubular shaft and the contraction-facilitating knob are in threaded connection with each other, and</li><li>wherein the handle portion is configured such that actuation of the contraction-facilitating knob rotates the tubular shaft, thereby advancing the tubular shaft proximally with respect to the outer housing.</li></ul></li><li>117. The apparatus according to any one of embodiments 114 to 116, <ul id="ul0046" list-style="none" compact="compact"><li>wherein the inner shaft partially protrudes out of a proximal end of the outer housing, and</li><li>wherein the tubular shaft and the inner shaft together provide a non-electrical mechanical force gauge, in which a relative axial position of the tubular shaft with respect to the inner shaft provides a visual indication of a measure of the tension in the contracting member.</li></ul></li><li>118. The apparatus according to embodiment 117, wherein the inner shaft is marked with a plurality of fiduciary markers, which are arranged along the inner shaft to indicate the relative axial position of the tubular shaft with respect to the inner shaft.</li><li>119. The apparatus according to any one of embodiments 114 to 116, wherein the handle portion further comprises a tension-limiting locking assembly, which is configured to axially lock the inner shaft with respect to the outer housing when the handle portion increases the tension in the contracting member to a predetermined threshold level, thereby limiting a maximum tension that the inner shaft can apply to the contracting member.</li><li>120. The apparatus according to embodiment 119, wherein the tension-limiting locking assembly is configured to axially lock the inner shaft with respect to the outer housing when the tubular shaft is disposed at a predetermined relative axial position with respect to the inner shaft, thereby limiting the maximum tension that the inner shaft can apply to the contracting member.</li><li>121. The apparatus according to embodiment 120, wherein the tension-limiting locking assembly comprises a detent, which is arranged to axially lock the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft, thereby limiting the maximum tension that the inner shaft can apply to the contracting member.</li><li>122. The apparatus according to embodiment 121, wherein the detent is coupled in axial fixation with the inner shaft and is configured to move radially outward so as to engage the outer housing in order to axially lock the inner shaft with respect to the outer housing.</li><li>123. The apparatus according to embodiment 122, <ul id="ul0047" list-style="none" compact="compact"><li>wherein the tension-limiting locking assembly further comprises a plurality of indentations that the outer housing is shaped so as to define,</li><li>wherein the detent is engageable with the indentations to axially lock the inner shaft with respect to the outer housing, and</li><li>wherein the handle portion is arranged such that the particular one of the indentations with which the detent engages depends upon a relative axial position of the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft.</li></ul></li><li>124. The apparatus according to embodiment 122, wherein the proximal longitudinal portion of the tubular shaft is shaped so as to define an elongate opening through which the detent passes when the detent axially locks the inner shaft with respect to the outer housing.</li><li>125. The apparatus according to embodiment 124, wherein the tubular shaft comprises one or more tracks that run alongside a longitudinal portion of the elongate opening and are arranged to: <ol id="ol0005" compact="compact"><li>(a) prevent the detent from axially locking the inner shaft with respect to the outer housing when the tubular shaft is disposed distally to the predetermined relative axial position with respect to the inner shaft, and</li><li>(b) allow the detent to axially lock the inner shaft when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft.</li></ol></li><li>126. The apparatus according to embodiment 125, wherein the one or more tracks are shaped so as to define one or more respective sloping portions, such that after the detent axially locks the inner shaft with respect to the outer housing when the tubular shaft is disposed at the predetermined relative axial position with respect to the inner shaft, subsequent distal motion of the tubular shaft and consequently the one or more tracks with respect to the inner shaft disengages the detent from the outer housing.</li><li>127. The apparatus according to embodiment 119, <ul id="ul0048" list-style="none" compact="compact"><li>wherein the inner shaft partially protrudes out of a proximal end of the outer housing, and</li><li>wherein the tubular shaft and the inner shaft together provide a non-electrical mechanical force gauge, in which a relative axial position of the tubular shaft with respect to the inner shaft provides a visual indication of a measure of the tension in the contracting member.</li></ul></li><li>122. The apparatus according to any one of embodiments 114 to 116, wherein the implantable structure comprises an implantable annuloplasty structure.</li><li>123. The apparatus according to embodiment 122, wherein the implantable annuloplasty structure comprises a flexible sleeve, and wherein the contracting member extends along and away from the sleeve.</li><li>124. Apparatus comprising: <ul id="ul0049" list-style="none" compact="compact"><li>an implant comprising an implantable structure and a flexible elongated contracting member that extends away from the implantable structure; and</li><li>a contracting-member-uptake tool, which comprises a handle portion, which (a) is shaped so as to define a handle contracting-member-receiving channel from a distal end through to a proximal end of the handle portion, and (b) comprises: <ul id="ul0050" list-style="none" compact="compact"><li>an outer housing;</li><li>a non-electrical mechanical force gauge;</li><li>a lock, which is configured (i) when in an unlocked state, to allow sliding of the contracting member with respect to the force gauge, and (ii) when in a locked state, to axially lock the contracting member with respect to an axially-movable portion of the force gauge, wherein the axially-movable portion of the force gauge is axially-movable with respect to the outer housing; and</li><li>a contraction-facilitating knob, which is accessible from outside the outer housing,</li></ul></li><li>wherein the handle portion is configured such that actuation of the contraction-facilitating knob, when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel and the lock is in the locked state, causes the handle portion to uptake successive portions of the contracting member by advancing the force gauge proximally with respect to the outer housing so as to proximally pull the contracting member,</li><li>wherein the handle portion is configured such that upon the actuation of the contraction-facilitating knob when the contracting member is disposed passing entirely through the handle contracting-member-receiving channel, the lock is in the locked state, and the contracting member is tensed, proximal pulling of the contracting member by the axially-movable portion of the force gauge increases tension in the contracting member, and</li><li>wherein the force gauge is configured to provide a visual indication of a measure of the tension in the contracting member.</li></ul></li><li>125. The apparatus according to embodiment 124, wherein the force gauge comprises a spring.</li><li>126. The apparatus according to embodiment 125, wherein the force gauge is configured such that the spring applies a proximally-directed force to the axially-movable portion of the force gauge.</li><li>127. The apparatus according to any one of embodiments 124 to 126, wherein the handle portion further comprises a tension-limiting locking assembly, which is configured to axially lock the axially-movable portion of the force gauge with respect to the outer housing when the handle portion increases the tension in the contracting member to a predetermined threshold level, thereby limiting a maximum tension that the axially-movable portion of the force gauge can apply to the contracting member.</li><li>128. A method, comprising: <ul id="ul0051" list-style="none" compact="compact"><li>advancing toward a simulated heart of a patient an implantable annuloplasty structure including: <ul id="ul0052" list-style="none" compact="compact"><li>a primary body portion; and</li><li>a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary portion of the annuloplasty ring structure; and</li></ul></li><li>threading the second portion of the contracting member through a contracting-member-uptake tool, the contracting-member-uptake tool including: <ul id="ul0053" list-style="none" compact="compact"><li>a primary tube terminating at a distal end portion of the contracting-member-uptake tool, the distal end portion of the contracting-member-uptake tool having a distal tip;</li><li>a secondary tube disposed alongside the primary tube, the secondary tube having a secondary-tube lumen being configured for passage therethrough of the contracting member; and</li><li>a contracting-member-snare comprising a distal snare portion and an elongate flexible body portion coupled to the distal snare portion, the distal snare portion being configured to ensnare a portion of the contracting member and being sized to pass through the secondary-tube lumen of the secondary tube in order to pull the second portion of the contracting member through a length of the secondary tube,</li><li>wherein threading comprises: <ul id="ul0054" list-style="none" compact="compact"><li>using the distal snare portion, ensnaring the portion of the contracting member;</li><li>using the contracting-member-snare, pulling the portion of the contracting member through the secondary tube; and</li><li>subsequently to the threading, advancing the contracting-member-uptake tool along the contracting member toward the annuloplasty structure.</li></ul></li></ul></li></ul></li><li>129. The method according to embodiment 128, wherein pulling the portion of the contracting member through the secondary tube comprises pulling the second portion of the contracting member through the distal tip of the contracting-member-uptake tool and subsequently through the length of the secondary tube.</li><li>130. The method according to any one of embodiments 128 to 129, further comprising, subsequently to the advancing of the contracting-member-uptake tool, contracting the annuloplasty structure using the contracting-member-uptake tool.</li><li>131. The method according to embodiment 130, further comprising using a sharp edge of the contracting-member-uptake tool to sever the contracting member.</li><li>132. A method, comprising: <ul id="ul0055" list-style="none" compact="compact"><li>advancing toward a simulated heart an implantable annuloplasty structure comprising: <ul id="ul0056" list-style="none" compact="compact"><li>a primary body portion;</li><li>a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary body portion of the annuloplasty structure; and</li><li>a housing coupled to the primary body portion of the annuloplasty structure;</li><li>a contracting-member-fastener disposed within the housing, the contracting-member-fastener comprising a clamping structure that (a) is biased toward assuming a closed state, in the closed state, the clamping structure is configured to clamp onto the contracting member passed therethrough, and (b) can be flexed to an open state through which the contracting member can move; and</li><li>a stop removably coupled to the fastener and configured to maintain the contracting-member-fastener in the open state; and</li></ul></li><li>converting the contracting-member-fastener from the open state to the closed state in order to clamp onto the contracting member passed therethrough by moving a fastener-ejector engageable with the stop such that movement of the fastener-ejector moves the stop removably coupled to the fastener.</li></ul></li><li>133. The method according to embodiment 132, further comprising, subsequently to the advancing, contracting the annuloplasty structure using the contracting member, and wherein converting the contracting-member-fastener from the open state to the closed state comprising converting subsequently to the contracting.</li><li>134. The method according to embodiment 133, wherein contracting the annuloplasty structure comprises contracting the annuloplasty structure using a contracting-member-uptake tool and further comprising, subsequently to the converting of the contracting-member-fastener from the open state to the closed state, using a sharp edge of the contracting-member-uptake tool, severing the contracting member.</li><li>135. A method, comprising: <ul id="ul0057" list-style="none" compact="compact"><li>advancing toward a simulated heart an implantable annuloplasty structure including: <ul id="ul0058" list-style="none" compact="compact"><li>a primary body portion having a lateral wall; and</li><li>a contracting member having (1) a first portion extending along a longitudinal length of the primary body portion of the annuloplasty structure, and (2) a second portion extending away from the primary body portion of the annuloplasty structure, the contracting member being configured to adjust a perimeter of the annuloplasty structure,</li><li>the primary body portion of the annuloplasty structure being shaped to define a recess having a recess axis, the recess extending from an opening in a first surface of the lateral wall of the primary body portion toward an opposite second surface of the lateral wall of the primary body portion, the lateral wall of the primary body portion extending away from the recess along a longitudinal axis that is at a non-zero angle with respect to the recess axis, the contracting member extending through the recess and away from the primary body portion of the annuloplasty structure via the recess; and</li></ul></li><li>locking the contracting member by sliding a lock along the contracting member to fit within the recess, the lock being fixedly couplable to the contracting member in order to prevent movement of the contracting member, the recess being shaped so as to facilitate fixed coupling of the lock to the contracting member.</li></ul></li><li>136. The method according to embodiment 135, wherein advancing comprises advancing the annuloplasty structure using a delivery tool, and wherein the method further comprises sliding the delivery tool and the contracting member with respect to each other.</li><li>137. A method, comprising: <ul id="ul0059" list-style="none" compact="compact"><li>threading a contracting-member-severing tool along a contracting member, the contracting-member-severing tool including a cutting element in proximity with the contracting member during the threading;</li><li>engaging the tool with a stop that is removably coupled to a contracting-member-fastener surrounding a portion of the contracting member, the stop being configured to maintain the contracting-member-fastener in an open state;</li><li>using the tool, disengaging the stop from the contracting-member-fastener by pulling the stop with the tool; and</li><li>by the pulling, contacting the stop with the cutting element and facilitating pushing of the stop against the cutting element, and by the pushing, facilitating moving of the cutting element, and thereby facilitating severing of the contracting member by the cutting element.</li></ul></li><li>138. The method according to embodiment 137, wherein the tool is arranged such that the tool provides a safety mechanism whereby the moving of the cutting element is possible only by the pushing of the stop against the cutting element.</li><li>139. The method according to any one of embodiments 137 to 138, further including a housing that houses the fastener and the stop, and wherein the method comprises coupling the tool to the housing by gasping the stop with the tool.</li><li>140. The method according to embodiment 139, further comprising, using the tool, delivering the housing, the fastener, and the stop to an implantable annuloplasty structure, wherein the stop is shaped so as to define an overhang, and wherein engaging the tool with a stop comprises initially coupling the tool to the fastener by gripping the overhang with the tool with graspers.</li><li>141. A method comprising: <ul id="ul0060" list-style="none" compact="compact"><li>advancing toward a simulated heart an implantable structure of an implant and a flexible elongated contracting member that extends away from the implantable structure;</li><li>threading a portion of the contracting member through a handle contracting-member-receiving channel of a handle portion of a contracting-member-uptake tool, which further includes: <ul id="ul0061" list-style="none" compact="compact"><li>an outer housing,</li><li>a non-electrical mechanical force gauge,</li><li>a lock, which is configured (i) when in an unlocked state, to allow sliding of the contracting member with respect to the force gauge, and (ii) when in a locked state, to axially lock the contracting member with respect to an axially-movable portion of the force gauge, wherein the axially-movable portion of the force gauge is axially-movable with respect to the outer housing, and</li><li>a contraction-facilitating knob, which is accessible from outside the outer housing;</li></ul></li><li>transitioning the lock from the unlocked state to the locked state;</li><li>thereafter, actuating the contraction-facilitating knob to cause the handle portion to uptake successive portions of the contracting member by advancing the force gauge proximally with respect to the outer housing so as to proximally pull the contracting member;</li><li>thereafter, once the contracting member is tensed, actuating the contraction-facilitating knob to increase tension in the contracting member by proximal pulling of the contracting member by the axially-movable portion of the force gauge; and</li><li>viewing a visual indication of a measure of the tension in the contracting member, the visual indication provided by the force gauge.</li></ul></li><li>142. The method according to embodiment 141, wherein the handle portion further includes a tension-limiting locking assembly, which is configured to axially lock the axially-movable portion of the force gauge with respect to the outer housing when the handle portion increases the tension in the contracting member to a predetermined threshold level, thereby limiting a maximum tension that the axially-movable portion of the force gauge can apply to the contracting member.</li></ul>