Reposable clip applier

<u>CROSS-REFERENCE TO RELATED</u><u>APPLICATIONS</u>

0001This application claims the benefit of and priority to <patcit id="pcit0001" dnum="US62100632A"><text>U.S. Provisional Patent Application No. 62/100,632, filed January 7, 2015</text></patcit>, the entire disclosure of which is incorporated by reference herein.

<u>BACKGROUND</u>

<u>Technical Field</u>

0002The present disclosure relates to surgical clip appliers. More particularly, the present disclosure relates to reposable endoscopic surgical clip appliers.

<u>Description of Related Art</u>

0003Clip appliers are used in surgical procedures to apply a surgical clip to a blood vessel or another duct to prevent the flow of body fluids therethrough. Clip appliers are used during a variety of surgical procedures, some of which include, open surgery, endoscopic procedures, and robotically controlled procedures. Clip appliers that apply multiple clips generally provide a plurality of surgical clips stored in a clip cartridge mounted at the distal end of the clip applier. The clips from the clip cartridge are fed sequentially to jaws defined by a jaw blade at the distal end of the instrument upon actuation of handles at the proximal end of the instrument. As the handles are closed, the jaws close to deform a surgical clip positioned between the jaws, and as the jaws are opened to release the deformed surgical clip, a new surgical clip is fed from the clip cartridge to a position between the jaws. This process is repeated until all the surgical clips in the clip cartridge have been applied. A new clip cartridge can then be positioned on the clip applier.

0004Some clip appliers include complicated internal structure(s) that prevent effective re-sterilization and are therefore single use, disposable instruments. Reposable clip appliers are instruments having a body that can be re-sterilized and re-used a number of times. It would be desirable to provide improved clip cartridge and jaw blade components for a reposable surgical clip applier to facilitate simple and easy disassembly and re-assembly of the instrument during sterilization.

<u>SUMMARY</u>

0005In accordance with an aspect of the present disclosure, a surgical clip applier is provided. The surgical clip applier comprises an actuation mechanism, a body portion, a jaw blade, and a clip cartridge. The jaw blade being removably disposed within the body portion and including first and second opposed jaws operably connected to the actuation mechanism for selective movement between a spaced apart position and an approximated position to effectuate closure of a surgical clip. The first and second opposed jaws of the jaw blade connected to each other at a proximal end by a shank section. The clip cartridge being removably disposed within the body portion adjacent the jaw blade and configured to store at least one surgical clip therein. The clip cartridge having a first nub and a second nub, wherein the first nub of the clip cartridge abuts a first end of the shank section of the jaw blade, and the second nub of the clip cartridge abuts a second end of the shank section of the jaw blade.

0006In one embodiment, the second nub of the clip cartridge is disposed between the proximal ends of the first and second opposed jaws.

0007In another embodiment, the first and second opposed jaws of the jaw blade are symmetrically disposed along a longitudinal axis of the shank section.

0008In another embodiment, the first and second opposed jaws of the jaw blade define an open cavity, such that the open cavity tapers to the second end of the shank section of the jaw blade.

0009In a further embodiment, the spaced apart position of the opposed jaws of the jaw blade defines a width and the at least one surgical clip disposed in the clip cartridge has an unformed width, such that the width defined by the opposed jaws corresponds to the unformed width of the at least one surgical clip.

0010In yet another embodiment, at least one of the first and second nubs of the clip cartridge is a cylindrical pin.

0011In accordance with another aspect of the present disclosure, a method of applying a surgical clip is provided. The method includes providing a surgical clip applier, the surgical clip applier including an actuation mechanism and a body portion. The method may also include providing a jaw blade, the jaw blade being removably disposed within the body portion and including first and second opposed jaws operably connected to the actuation mechanism for selective movement between a spaced apart position and an approximated position to effectuate closure of a surgical clip. The first and second opposed jaws of the jaw blade connected to each other at a proximal end by a shank section. The method may further include providing a clip cartridge, the clip cartridge being removably disposed within the body portion adjacent the jaw blade and configured to store at least one surgical clip therein. The clip cartridge having a first nub and a second nub, such that the first nub of the clip cartridge abuts a first end of the shank section of the jaw blade, and the second nub of the clip cartridge abuts a second end of the shank section of the jaw blade. The method may include, inserting the jaw blade into the body portion of the surgical clip applier and inserting the clip cartridge into the body portion. Lastly, the method may include, actuating the actuation mechanism of the surgical clip applier, the actuation directing the surgical clip disposed in the clip cartridge to be loaded into the opposing jaws of the jaw blade, the actuation further causing cooperative movement of the opposing jaws of the jaw blade from the spaced apart position to the approximated position effectuating closure of the surgical clip disposed therein.

0012In yet another aspect of the present disclosure, the method further includes, providing a plurality of clip cartridges, wherein each respective clip cartridge includes a surgical clip having a different unformed width disposed therein. The method may also include providing a plurality of jaw blades, such that a width defined by the opposing jaws of a respective jaw blade in the spaced apart position corresponds respectively to the different widths of the unformed surgical clips disposed within the provided clip cartridges. The method may further include selecting a specific surgical clip width and a corresponding surgical clip cartridge, and selecting a jaw blade wherein the width of the opposing jaws correspond to the selected surgical clip cartridge. The method may also include inserting the selected jaw blade into the body portion of the surgical clip applier, and inserting the selected clip cartridge into the body portion. Lastly, the method may include actuating the actuation mechanism of the surgical clip applier, the actuation mechanism directing the surgical clip disposed in the selected clip cartridge to be loaded into the opposing jaws of the selected jaw blade, the actuation mechanism further causing cooperative movement of the opposing jaws of the selected jaw blade from the spaced apart position to the approximated position effectuating closure of the surgical clip disposed therein.

0013In yet another aspect of the present disclosure, a kit is provided. The kit includes a package containing, a clip cartridge loaded with a plurality of surgical clips, wherein each surgical clip defines a width, and a jaw blade including first and second opposed jaws. The jaw blade being configured for selective connection to an actuation mechanism of a surgical clip applier for selective movement between a spaced apart position and an approximated position to effectuate closure of a surgical clip. A width defined by the opposing jaws of the jaw blade, when in the spaced apart position, corresponds respectively to the width of the surgical clips of the clip cartridge. The kit may further include in the package a clip applier, the clip applier including an actuation mechanism and a body portion, the body portion being configured to removeably receive the jaw blade and the clip cartridge therein. The kit may also include in the package a plurality of clip cartridges, wherein each respective clip cartridge includes a surgical clip disposed therein defining a respective unformed surgical clip width, and a plurality of jaw blades, such that the width defined by the opposing jaws of the jaw blades correspond to the respective widths of the unformed surgical clips disposed within the plurality of clip cartridge. The kit may also include in the package instructions for use.

0014In yet another aspect of the present disclosure, a kit is provide including a package containing a clip cartridge loaded with a plurality of surgical clips, wherein each surgical clip defines a width, and a jaw blade including first and second opposed jaws. The jaw blade being configured for selective connection to an actuation mechanism of a surgical clip applier for selective movement between a spaced apart position and an approximated position to effectuate closure of a surgical clip, wherein a width defined by the opposing jaws of the jaw blade, when in the spaced apart position, corresponds respectively to the width of the surgical clips of the clip cartridge. The kit may further include a plurality of clip cartridges, wherein each respective clip cartridge includes a surgical clip disposed therein defining a respective unformed surgical clip width, and a plurality of jaw blades, such that the width defined by the opposing jaws of the jaw blades correspond to the respective widths of the unformed surgical clips disposed within the plurality of clip cartridge.

<u>BRIEF DESCRIPTION OF THE DRAWINGS</u>

0015Various embodiments of the subject instrument are described herein with reference to the drawings wherein: <ul id="ul0001" list-style="none" compact="compact"><li><figref idref="f0001">FIG. 1</figref> is a perspective view of a surgical clip applier according to an embodiment of the present disclosure;</li><li><figref idref="f0002">FIG. 2</figref> is a side view of the distal end of the elongated body portion of the surgical clip applier of <figref idref="f0001">FIG. 1</figref> with a removable clip cartridge and a jaw blade loaded therein;</li><li><figref idref="f0002">FIG. 3</figref> is a plan view of the distal end of the elongated body with the removable clip cartridge and removable jaw blade of <figref idref="f0002">FIG. 2</figref> loaded therein;</li><li><figref idref="f0003">FIG. 4A</figref> is a cross-sectional view, as taken through 4-4 of <figref idref="f0002">FIG. 2</figref>, of the distal end of the elongated body, and the jaw blade;</li><li><figref idref="f0003">FIG. 4B</figref> is a plan view of one embodiment of an unformed surgical clip of the present disclosure;</li><li><figref idref="f0003">FIG. 5</figref> is a side view of one embodiment of the removable clip cartridge of the present disclosure;</li><li><figref idref="f0004">FIG. 6</figref> is a plan view of one embodiment of the jaw blade of the present disclosure;</li><li><figref idref="f0004">FIG. 7</figref> is a side view, with parts separated, of the jaw blade and clip cartridge;</li><li><figref idref="f0004">FIG. 8</figref> is a cross-sectional view, as taken through 8-8 of <figref idref="f0002">FIG. 3</figref>, of the jaw blade and clip cartridge;</li><li><figref idref="f0005">FIG. 9A</figref> is a kit in accordance with an embodiment of the present disclosure including a jaw blade, clip cartridge, and instructions for use;</li><li><figref idref="f0005">FIG. 9B</figref> is a kit in accordance with an embodiment of the present disclosure including a jaw blade, a clip cartridge, a surgical clip applier, and instructions for use;</li><li><figref idref="f0005">FIG. 9C</figref> is a kit in accordance with an embodiment of the present disclosure including multiple jaw blades, multiple clip cartridges, and instructions for use; and</li><li><figref idref="f0005">FIG. 9D</figref> is a kit in accordance with an embodiment of the present disclosure including multiple jaw blades, multiple clip cartridges, a surgical clip applier, and instructions for use.</li></ul>

<u>DETAILED DESCRIPTION</u>

0016Embodiments of a surgical clip applier in accordance with the present disclosure will now be described in detail with reference to the drawing figures wherein like reference numerals identify similar or identical structural elements. As shown in the drawings and described throughout the following description, as is traditional when referring to relative positioning on a surgical instrument, the term "proximal" refers to the end of the apparatus which is closer to the user and the term "distal" refers to the end of the apparatus which is further away from the user.

0017Referring briefly to <figref idref="f0001 f0002">FIGS. 1-3</figref>, a surgical clip applier in accordance with the present disclosure is generally designated as 100. Surgical Clip applier 100 generally includes an actuation mechanism and a body portion 110 extending distally from the actuation mechanism. The actuation mechanism may take a variety of forms, such as, a handle assembly or a robotically assisted surgical system which permits remote operation and control of surgical instruments.

0018With reference to <figref idref="f0001 f0002">FIGS. 1-3</figref>, an embodiment of surgical clip applier 100 including a handle assembly 102, will be described. Handle assembly 102 includes a moveable handle 104 and a stationary hand grip 106. Handle assembly 102 supports a body portion 110 having a proximal end 112 and a distal end 114. The body portion defines an open cavity 116 disposed at or near distal end 114 thereof. Surgical clip applier 100 includes or is capable of receiving a clip cartridge 150 and a jaw blade 160 in cavity 116 disposed at distal end 114 of the body portion 110. Clip cartridge 150 and jaw blade 160 are both removable from within open cavity 116 of body portion 110. During use, multiple surgical clips are typically loaded and/or retained within clip cartridge 150. Clip cartridge 150 and jaw blade 160 are disposed within the open cavity 116 at the distal end 114 of the body portion 110, and upon actuation of the moveable handle 104 in direction "A", towards stationary hand grip 106, clip cartridge 150 and jaw blade 160 cooperatively engage to load a unformed surgical clip between first and second jaw sections 192, 194 of the jaw blade 160 and clamp a surgical clip. A complete description of the inner-workings and operation of an exemplary surgical clip applier 100 can be found in commonly-assigned <patcit id="pcit0002" dnum="US20080243145A1"><text>U.S. Patent Publication No. 2008/0243145 A1</text></patcit> to Whitfield et. al., the entire contents of which are hereby incorporated by reference herein.

0019Referring briefly to <figref idref="f0003">FIG. 4A</figref>, a cross-sectional view of the distal end 114 of the body portion 110 is shown without clip cartridge 150 installed. Jaw blade 160 is disposed at the distal end 114 such that a portion of jaw blade 160 extends past the distal end 114 of the body portion 110.

0020Turning now to <figref idref="f0003">FIG. 5</figref>, clip cartridge 150 includes a first extrusion or nub 152 and a second extrusion or nub 154 extending from a channel, body, or the like 151 of clip cartridge 150. First nub 152 and second nub 154 are longitudinally spaced apart from one another and protrude in a common direction from body 151 of clip cartridge 150.

0021As seen in <figref idref="f0004">FIGS. 6 and 8</figref>, jaw blade 160 includes a shank section 162 having a first end 164 and a second end 166, a first leg member 170 which extends distally from the second end 166 of the shank section 162, and a second leg member 180 which extends distally from the second end 166 of the shank section 162. In embodiments, first and second leg members 170, 180 are symmetrically disposed along longitudinal axis "A" defined by jaw blade 160. First leg member 170 and second leg member 180 have a respective proximal end 172, 182, and a respective distal end 174, 184. Jaw blade 160 further includes a first jaw section 192 and a second jaw section 194, which together form or define jaw 190. First jaw section 192 and second jaw section 194 are disposed at the distal end 174, 184 of the first and section leg member, 170, 180, respectively. During actuation of the actuation mechanism, the first jaw section 192 and second jaw section 194 of jaw 190 come together to clamp or form a surgical clip "C" disposed or loaded therebetween as shown in <figref idref="f0003">FIG. 4A</figref>.

0022With reference to <figref idref="f0004">FIGS. 7 and 8</figref>, the interaction of clip cartridge 150 and jaw blade 160 are described. In one embodiment of the present disclosure, with jaw blade 160 mounted within open cavity 116 at the distal end 114 of the body portion 110, and clip cartridge 150 loaded into open cavity 116 at the distal end 114 of the body portion 110, the first nub 152 of clip cartridge 150 abuts the first end 164 of the shank section 162 of jaw blade 160 while the second nub 154 of clip cartridge 150 abuts the second end 166 of the shank section 162 of jaw blade 160 such that the second nub 154 of clip cartridge 150 extends between the proximal end 172, 182 of first and second leg member 170, 180, respectively. Once clip cartridge 150 and jaw blade 160 are disposed or loaded into the open cavity 116 at the distal end 114 of the body portion 110, first and second nubs 152, 154 of clip cartridge 150 act to arrest, prevent, or otherwise block longitudinal and vertical movement of the jaw blade 160 while still allowing first and second jaw sections 192, 194 to open and close to form a surgical clip "C" positioned therebetween.

0023Specifically, when jaw blade 160 is coupled with clip cartridge 150, movement of jaw blade 160 will be arrested, prevented, or otherwise blocked along the longitudinal axis "A" defined by jaw blade 160, shown in <figref idref="f0004">FIGS. 6 and 8</figref>. Further, vertical movement of jaw blade 160 will be arrested, prevented, or otherwise blocked along axis "B", shown in <figref idref="f0004">FIG. 8</figref>, which lies perpendicular to the longitudinal axis "A". With jaw blade 160 and clip cartridge 150 coupled, during actuation of handle 102 of the actuation mechanism, jaw blade 160 is only capable of transverse motion of the first and second leg members 170, 180 of jaw blade 160 for the opening and closing of first and second jaw sections 192, 194 to clamp or form at least one surgical clip.

0024As seen in <figref idref="f0003 f0004">FIGS. 5-7</figref>, first and second nubs 152, 154 of clip cartridge 150 may be cylindrical pins. It is envisioned, that first and second nubs 152, 154 of clip cartridge 150 are any geometric shape capable of engaging the shank section 162 of jaw blade 160, such that when clip cartridge 150 abuts jaw blade 160, longitudinal and vertical motion of jaw blade 160 is arrested, prevented, or otherwise blocked.

0025First and second leg members 170, 180 have a first condition (as seen in <figref idref="f0003">FIGS. 4A</figref> and <figref idref="f0004">6</figref>) and a second condition (not shown). In the first condition, the distal ends 174, 184 of the first and second leg members 170, 180 define a jaw space opening 196 therebetween having a width "JW" (as seen in <figref idref="f0003">FIG. 4A</figref>). In the second condition the distal ends 174, 184 of the first and second leg members 170, 180 are in close proximity, or in abutting relationship to one another, thus reducing the jaw space opening 196. As seen in <figref idref="f0002">FIGS. 3</figref>, <figref idref="f0003">4A</figref>, and <figref idref="f0004">6</figref>, the actuation mechanism is in a pre-actuation condition, the first and second leg members 170, 180 of jaw blade 160 are in the first condition.

0026The method of applying a surgical clip using the surgical clip applier in accordance with the present disclosure will be described with reference to <figref idref="f0001 f0002 f0003 f0004">FIGS. 1-8</figref>. An operator is provided with surgical clip applier 100, a clip cartridge 150, and a jaw blade 160. The operator will first insert jaw blade 160 into the open cavity 116 at the distal end 114 of the body portion 110. The operator will next insert clip cartridge 150 into open cavity 116 at the distal end 114 of the body portion 110, such that clip cartridge 150 abuts jaw blade 160 as noted above. Once assembled, longitudinal and vertical movement of jaw blade 160 will be arrested, prevented, or otherwise blocked. Jaw blade 160, when disposed at the distal end 114 of the body portion 110, is operably connected to an actuation mechanism for selective closure of the first and second jaw section 192, 194 upon activation of the actuation mechanism. In one embodiment of the present disclosure, the actuation mechanism of surgical clip applier 100 takes the form of handle assembly 102. Clip cartridge 150, when disposed at the distal end 114 of the body portion 110, abuts jaw blade 160, such that first nub 152 abuts the first end 164 of the shank section 162 of jaw blade 160, and second nub 154 abuts the second end 166 of the shank section 162 of jaw blade 160.

0027It is further envisioned, in accordance with the present disclosure, that the operator of surgical clip applier 100 will have a variety of surgical clip widths to choose from. Specially, a plurality of clip cartridges 150 are provided, wherein a respective clip cartridge 150 contains a surgical clip "C" having a respective unformed clip width "CW" disposed therein, as shown in <figref idref="f0003">FIG. 4B</figref>. A plurality of jaw blades are provided, such that width "JW" defined by jaw space opening 196 of the provided jaw blades 160 correspond to the provided variety of unformed surgical clip widths "CW" disposed in the respective clip cartridges 150 provided. Based on the surgical procedure and needs of the operator, the operator selects a specific clip cartridge 150, having the desired unformed surgical clip width "CW" disposed therein. Based on the selected unformed surgical clip width "CW", the operator selects the jaw blade 160 with the corresponding jaw width "JW".

0028In accordance with the present disclosure, a kit will be described with reference to <figref idref="f0001 f0002 f0003 f0004 f0005">FIGS. 1-9</figref>. The kit includes a clip cartridge 150 and a jaw blade 160 in a common package 300 to be used with or in a clip applier, as shown in <figref idref="f0005">FIG. 9A</figref>. The kit may include surgical clip applier 100, as shown in <figref idref="f0005">FIG. 9B</figref>. In embodiments, the kit may include a plurality of clip cartridges 150a-c contained in a common package 300, wherein each respective clip cartridge 150 contains at least one surgical clip "C" having a different unformed surgical clip width "CW" disposed therein respectively, as shown in <figref idref="f0005">FIG. 9C and 9D</figref>. The kit may also include a plurality of jaw blades 160a-c corresponding to the plurality of clip cartridges 150a-c and the variety of surgical clip widths "CW" provided therein, as shown in <figref idref="f0005">FIG. 9C and 9D</figref>. The kit may also include instructions for use 310, as shown in <figref idref="f0005">FIGS. 9A-D</figref>. The common package 300 may include a thermoformed plastic tray and/or other packaging materials within the view of those skilled in the art.

0029The various embodiments disclosed herein may also be configured to work with robotic surgical systems and what is commonly referred to as "Telesurgery." Such systems employ various robotic elements to assist the surgeon and allow remote operation (or partial remote operation) of surgical instrumentation. Various robotic arms, gears, cams, pulleys, electric and mechanical motors, etc. may be employed for this purpose and may be designed with a robotic surgical system to assist the surgeon during the course of an operation or treatment. Such robotic systems may include remotely steerable systems, automatically flexible surgical systems, remotely flexible surgical systems, remotely articulating surgical systems, wireless surgical systems, modular or selectively configurable remotely operated surgical systems, etc.

0030The robotic surgical systems may be employed with one or more consoles that are next to the operating theater or located in a remote location. In this instance, one team of surgeons or nurses may prep the patient for surgery and configure the robotic surgical system with one or more of the instruments disclosed herein while another surgeon (or group of surgeons) remotely controls the instruments via the robotic surgical system. As can be appreciated, a highly skilled surgeon may perform multiple operations in multiple locations without leaving his/her remote console which can be both economically advantageous and a benefit to the patient or a series of patients.

0031The robotic arms of the surgical system are typically coupled to a pair of master handles by a controller. The handles can be moved by the surgeon to produce a corresponding movement of the working ends of any type of surgical instrument (e.g., end effectors, graspers, knifes, scissors, etc.) which may complement the use of one or more of the embodiments described herein. The movement of the master handles may be scaled so that the working ends have a corresponding movement that is different, smaller or larger, than the movement performed by the operating hands of the surgeon. The scale factor or gearing ratio may be adjustable so that the operator can control the resolution of the working ends of the surgical instrument(s).

0032The master handles may include various sensors to provide feedback to the surgeon relating to various tissue parameters or conditions, e.g., tissue resistance due to manipulation, cutting or otherwise treating, pressure by the instrument onto the tissue, tissue temperature, tissue impedance, etc. As can be appreciated, such sensors provide the surgeon with enhanced tactile feedback simulating actual operating conditions. The master handles may also include a variety of different actuators for delicate tissue manipulation or treatment further enhancing the surgeon's ability to mimic actual operating conditions.

0033A medical work station generally may include a plurality of robot arms, a control device, and an operating console coupled with the control device. The operating console may include a display device, which may be set up in particular to display three-dimensional images, and manual input devices, by means of which a person, for example a surgeon, may be able to telemanipulate the robot arms in a first operating mode.

0034Each of the robot arms may include a plurality of members, which are connected through joints, and an attaching device, to which may be attached, for example, a surgical tool supporting an end effector, in accordance with any one of several embodiments disclosed herein, as will be described in greater detail below.

0035The robot arms may be driven by electric drives that are connected to the control device. The control device (e.g., a computer) may be set up to activate the drives, in particular by means of a computer program, in such a way that the robot arms, their attaching devices, and thus the surgical tool (including the end effector) execute a desired movement according to a movement defined by means of the manual input devices. The control device may also be set up in such a way that it regulates the movement of the robot arms and/or of the drives.

0036The medical work station may be configured for use on a patient lying on a patient table to be treated in a minimally invasive manner by means of the end effector. The medical work station may also include more than two robot arms, the additional robot arms likewise being connected to the control device and being telemanipulatable by means of the operating console. A medical instrument or surgical tool (including an end effector) may also be attached to the additional robot arm. The medical work station may include a database, in particular coupled to the control device, in which are stored, for example, pre-operative data from the patient/living being and/or anatomical atlases.

0037It should be understood that the foregoing description is only illustrative of the present disclosure. Various alternatives and modifications can be devised by those skilled in the art without departing from the disclosure. Accordingly, the present disclosure is intended to embrace all such alternatives, modifications and variances. The embodiments described with reference to the attached drawing figures are presented only to demonstrate certain examples of the disclosure. Other elements, steps, methods and techniques that are insubstantially different from those described above and/or in the appended claims are also intended to be within the scope of the disclosure.

0038The invention may be described by reference to the following numbered paragraphs:- <ol id="ol0001" compact="compact" ol-style=""><li>1. A surgical clip applier comprising: <ul id="ul0002" list-style="none" compact="compact"><li>an actuation mechanism;</li><li>a body portion;</li><li>a jaw blade removably disposed within the body portion and including first and second opposed jaws operably connected to the actuation mechanism for selective movement between a spaced apart position and an approximated position to effectuate closure of a surgical clip, the first and second opposed jaws connected to each other at a proximal end by a shank section; and</li><li>a clip cartridge removably disposed within the body portion adjacent the jaw blade and configured to store at least one surgical clip therein, the clip cartridge having a first nub and a second nub, wherein the first nub of the clip cartridge abuts a first end of the shank section of the jaw blade, and the second nub of the clip cartridge abuts a second end of the shank section of the jaw blade.</li></ul></li><li>2. The surgical clip applier of paragraph 1, wherein the second nub of the clip cartridge is disposed between the proximal ends of the first and second opposed jaws.</li><li>3. The surgical clip applier of paragraph 1, wherein the first and second opposed jaws of the jaw blade are symmetrically disposed along a longitudinal axis of the shank section.</li><li>4. The surgical clip applier of paragraph 1, wherein the first and second opposed jaws of the jaw blade define an open cavity, such that the open cavity tapers to the second end of the shank section of the jaw blade.</li><li>5. The surgical clip applier of paragraph 1, wherein the spaced apart position of the opposed jaws of the jaw blade defines a width and the at least one surgical clip disposed in the clip cartridge has an unformed width, such that the width defined by the opposed jaws corresponds to the unformed width of the at least one surgical clip.</li><li>6. The surgical clip applier of paragraph 1, wherein at least one of the first and second nubs of the clip cartridge is a cylindrical pin.</li><li>7. The surgical clip applier of paragraph 1, wherein the actuation mechanism consists of a handle assembly including a moveable handle and a stationary grip, such that the jaw blade is operably connected to the handle assembly for selective closure upon actuation of the moveable handle.</li><li>8. A method of applying a surgical clip, comprising: <ul id="ul0003" list-style="none" compact="compact"><li>providing a surgical clip applier, the surgical clip applier including an actuation mechanism and a body portion;</li><li>providing a jaw blade, the jaw blade being removably disposed within the body portion and including first and second opposed jaws operably connected to the actuation mechanism for selective movement between a spaced apart position and an approximated position to effectuate closure of a surgical clip, the first and second opposed jaws connected to each other at a proximal end by a shank section; and</li><li>providing a clip cartridge, the clip cartridge being removably disposed within the body portion adjacent the jaw blade and configured to store at least one surgical clip therein, the clip cartridge having a first nub and a second nub, such that the first nub of the clip cartridge abuts a first end of the shank section of the jaw blade, and the second nub of the clip cartridge abuts a second end of the shank section of the jaw blade;</li><li>inserting the jaw blade into the body portion of the surgical clip applier;</li><li>inserting the clip cartridge into the body portion; and</li><li>actuating the actuation mechanism of the surgical clip applier, the actuation mechanism directing the surgical clip disposed in the clip cartridge to be loaded into the opposing jaws of the jaw blade, the actuation mechanism further causing cooperative movement of the opposing jaws of the jaw blade from the spaced apart position to the approximated position effectuating closure of the surgical clip disposed therein.</li></ul></li><li>9. The method of applying a surgical clip of paragraph 8, further comprising: <ul id="ul0004" list-style="none" compact="compact"><li>providing a plurality of clip cartridges, wherein each respective clip cartridge includes a different unformed surgical clip width disposed therein;</li><li>providing a plurality of jaw blades, such that a width defined by the opposing jaws of the jaw blades in the spaced apart position corresponds respectively to the different unformed surgical clips widths of the surgical clips disposed within the respective clip cartridges;</li><li>selecting a specific unformed surgical clip width and a corresponding surgical clip cartridge;</li><li>selecting a jaw blade wherein the width of the opposing jaws corresponds to the selected surgical clip cartridge;</li><li>inserting the selected jaw blade into the body portion of the surgical clip applier;</li><li>inserting the selected clip cartridge into the body portion; and</li><li>actuating the actuation mechanism of the surgical clip applier, the actuation mechanism directing the surgical clip disposed in the selected clip cartridge to be loaded into the opposing jaws of the selected jaw blade, the actuation mechanism further causing cooperative movement of the opposing jaws of the selected jaw blade from the spaced apart position to the approximated position effectuating closure of the surgical clip disposed therein.</li></ul></li><li>10. A kit, comprising: <ul id="ul0005" list-style="none" compact="compact"><li>a package containing, <ul id="ul0006" list-style="none" compact="compact"><li>a clip cartridge loaded with a plurality of surgical clips, wherein each surgical clip defines a width; and</li><li>a jaw blade including first and second opposed jaws, the jaw blade being configured for selective connection to an actuation mechanism of a surgical clip applier for selective movement between a spaced apart position and an approximated position to effectuate closure of a surgical clip, wherein a width defined by the opposing jaws of the jaw blade, when in the spaced apart position, corresponds respectively to the width of the surgical clips of the clip cartridge.</li></ul></li></ul></li><li>11. The kit of paragraph 10, wherein the package further includes a clip applier, the clip applier including an actuation mechanism and a body portion, the body portion being configured to removeably receive the jaw blade and the clip cartridge therein.</li><li>12. The kit of paragraph 11, wherein the package further includes: <ul id="ul0007" list-style="none" compact="compact"><li>a plurality of clip cartridges, wherein each respective clip cartridge includes a surgical clip disposed therein defining a respective unformed surgical clip width; and</li><li>a plurality of jaw blades, such that the width defined by the opposing jaws of the jaw blades correspond to the respective widths of the unformed surgical clips disposed within the plurality of clip cartridge.</li></ul></li><li>13. The kit of paragraph 10, wherein the package further includes: <ul id="ul0008" list-style="none" compact="compact"><li>a plurality of clip cartridges, wherein each respective clip cartridge includes a surgical clip disposed therein defining a respective unformed surgical clip width; and</li><li>a plurality of jaw blades, such that the width defined by the opposing jaws of the jaw blades correspond to the respective widths of the unformed surgical clips disposed within the plurality of clip cartridge.</li></ul></li><li>14. The kit of paragraph 12, wherein the package further includes instructions for use.</li></ol>