EP2543384A3

Treatment of conditions involving demyelination

Abstract

The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist. Additional methods include methods for inhibiting the binding of the Sp35 polypeptide with the ErbB2 polypeptide and a method for increasing ErbB2 phosphorylation by contacting oligodendrocytes with an effective amount of a composition comprising an Sp35 antagonist of the invention. Further embodiments of the invention include methods of inhibiting the binding of the Sp35 polypeptide with the ErbB2, increasing ErbB2 phosphorylation and promoting oligodendrocyte differentiation comprising contacting oligodendrocyte or oligodendrcoyte progenitor cells with an ErbB2 binding agent.

Term

Projected expiry 1 December 2026.

Every citation, both ways

Citations
Document	Relation	Office	Cited during
WO2004085648A2	Cites	World Intellectual Property Organization (WIPO)	Search report
WO2006002437A2	Cites	World Intellectual Property Organization (WIPO)	Search report

7 priority claims, no other members on record

This recordMember, by publication datePriority claim

Priority claims7

Priority claims
Document	Office	Kind	Date
741441P	United States of America	–	2005-12-02
74144105	United States of America	P	2005-12-02
06838776	European Patent Office (EPO)	A	2006-12-01
068387760	–	–	–
741441P	–	–	–
EP20060838776	–	–	–
US20050741441P	–	–	–

12 legal events, as the office reported them to INPADOC

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Events

Legal events, newest first
	Event	Code
2014-04-02	Application deemed to be withdrawnWithdrawn18D	18D
2014-02-28	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWNSTAA	STAA
2013-04-10	Designated contracting statesAK	AK
2013-04-10	Request for extension of the european patentAX	AX
2013-04-10	Information provided on ipc code assigned before grantRIC1	RIC1
2013-04-10	Information provided on ipc code assigned before grantRIC1	RIC1
2013-04-10	Information provided on ipc code assigned before grantRIC1	RIC1
2013-03-08	Search report despatchedORIGINAL CODE: 0009013PUAL	PUAL
2013-01-09	Divisional application: reference to earlier applicationAC	AC
2013-01-09	Designated contracting statesAK	AK
2013-01-09	Request for extension of the european patentAX	AX
2013-01-08	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI