Electrolytic drug-delivery pump with adaptive control

Technical Field

In various embodiments, the invention relates to drug-delivery pumps. In particular, embodiments of the invention relate to drug-delivery pumps whose actuation may be dynamically and adaptively controlled.

Background

Medical treatment often requires the administration of a therapeutic agent (e.g., medicament, drugs, etc.) to a particular part of a patient's body. As patients live longer and are diagnosed with chronic and/or debilitating ailments, the likely result will be an increased need to place even more protein therapeutics, small-molecule drugs, and other medications into targeted areas throughout the patient's body. Some maladies, however, are difficult to treat with currently available therapies and/or require administration of drugs to anatomical regions to which access is difficult to achieve.

A patient's eye is a prime example of a difficult-to-reach anatomical region, and many vision-threatening diseases, including retinitis pigmentosa, age-related macular degeneration (AMD), diabetic retinopathy, and glaucoma, are difficult to treat with many of the currently available therapies. For example, oral medications can have systemic side effects; topical applications may sting and engender poor patient compliance; injections generally require a medical visit, can be painful, and risk infection; and sustained-release implants must typically be removed after their supply is exhausted (and generally offer limited ability to change the dose in response to the clinical picture).

Another example is cancer, such as breast cancer or meningiomas, where large doses of highly toxic chemotherapies, such as rapamycin, bevacizumab (e.g., AVASTIN), or irinotecan (CPT-11), are typically administered to the patient intravenously, which may result in numerous undesired side effects outside the targeted area. Yet another example is drug delivery to the knee, where drugs often have difficulty penetrating the avascular cartilage tissue for diseases such as osteoarthritis.

Implantable drug-delivery devices (e.g., drug-delivery pumps), which may have a refillable drug reservoir, a cannula for delivering the drug, a check valve, etc., generally allow for controlled delivery of pharmaceutical solutions to a specified target. As drug within the drug reservoir depletes, the physician can refill the reservoir with, for example, a syringe, while leaving the device implanted within the patient' s body. This approach can minimize the surgical incision needed for implantation and typically avoids future or repeated invasive surgery or procedures.

Implantable drug-delivery pumps, particularly in ocular applications, often utilize a passive mechanism for drug delivery (e.g., pumping the drug out when a finger is pressed on the drug reservoir). One limitation of these conventional, passively-driven drug-delivery pumps is their inability to dynamically respond to changes inside the pump (e.g., failures, blockages, etc.) or to changes in the drug-delivery target area (e.g., increased pressure, bending of the pump's cannula, inflammation causing pressure around the cannula, etc.). The ability to respond to such changes can improve not only the therapeutic value of a pump, but also safety.

Active drug-delivery pumps, particularly feedback-driven ones, represent a substantial improvement over passively-driven pumps. Typically, these feedback-driven pumps are electrically-driven mechanical pumps. They generally employ controller units that receive inputs from sensors that monitor the target treatment area and, in response, direct the release of a pharmaceutical or therapeutic agent to achieve a desired result. The amount of drug released in each dosage period is thus largely determined by the current conditions of the target area and is intended to be variable depending on what the conditions of the target area warrant. Attention is drawn to the disclosure of <patcit id="pcit0001" dnum="WO2009086112A"><text>WO 2009/086112</text></patcit>. Attention is also drawn to the disclosures of <patcit id="pcit0002" dnum="WO0121234A"><text>WO 01/21234</text></patcit> and <patcit id="pcit0003" dnum="US2009028824A"><text>US 2009/028824</text></patcit>.

Pharmaceutical treatment regimens may, however, require that a drug be administered in fixed amounts at regular time intervals regardless of the changing conditions in the drug-delivery target area. Since the dosage levels produced by existing closed-loop feedback-driven systems can be highly dependent on the parameters of the treatment area and thus prone to fluctuations, they are inadequate for delivering fixed drug dosages at periodic intervals. For example, changes in the conditions of the target area, such as blockages or other biochemical or physiological events, may lead to variable levels of drug being delivered to the target area. Accordingly, there is a need for a feedback-driven pump that maintains the target dosage level despite such changes.

Furthermore, while feedback based on the conditions of the target area is important in numerous therapeutic applications, errors in drug administration can also arise from changing conditions within the pump itself. Conventional pumps generally do not account for such changes, which can also lead to variable amounts of drug being released. Accordingly, there is also a need for a drug-delivery pump that dynamically responds to changing conditions within the pump itself in order to, for example, consistently release a fixed dosage of drug at periodic time intervals.

Summary of the Invention

According to the present invention, there is provided a drug-delivery pump as defined in claim 1. In various embodiments, the present invention features an external or implantable drug-delivery pump that includes a dynamic, adaptive control system. The control system may operate the pump so as to release substantially fixed amounts of pharmaceutical or therapeutic agents to a target treatment area at regular intervals. In certain embodiments, the control system continuously monitors (either directly or indirectly) conditions internal to the pump that have an effect on the degree and duration of pump actuation and, consequently, the amount of drug that is released. As used herein, the term "substantially" means +10% (e.g., by weight or by volume), and in some embodiments, +5%.

The drug-delivery pump is an electrochemically-actuated pump, such as an electrolysis-driven pump. Electrochemically-actuated pumps, as compared to electrically-driven mechanical pumps, offer several advantages for drug-delivery systems. For example, they generally have few moving parts, which enables them to be small and portable, and which makes them less prone to mechanical breakdown than electrically-driven mechanical pumps. In particular, electrochemically- actuated pumps are suitable for environments that require small pump sizes, such as the ocular environment. As further described herein, an electrolysis-driven pump generally employs electrodes to generate an electrochemically active gas that variably pressurizes a drug contained in a separate chamber in order to dispense the drug in a controlled fashion. The amount of drug dispensed depends on the gas pressure variably generated by the pump actuator, which in turn depends on the current that passes through the electrodes. Because of the inherent variability in these electrolysis-driven pumps (e.g., the volume of gas and/or the amount of electrolyte can change between every pump cycle), the adaptive control design described herein can confer substantial advantages, as further explained below.

In general, in one aspect the invention features a drug-delivery pump that includes a drug reservoir, a cannula for conducting liquid from the reservoir to a target site, a pump actuator for forcing the liquid from the reservoir through the cannula, and circuitry for controlling the actuator. In particular, the circuitry controls the actuator i) to initially deliver a substantially fixed dosage of the liquid over time (e.g., at periodic time intervals or in an aspect related to the invention, through continuous infusion) to the target site, and ii) to compensate for a change in a condition of the pump so as to maintain or resume the delivery of the substantially fixed dosage of the liquid over time (e.g., at the periodic time intervals or in an aspect related to the invention , through the continuous infusion) to the target site.

In general, another aspect related to the invention features a method of delivering a drug to a patient from a drug-delivery pump that includes a drug reservoir and a pump actuator for forcing liquid from the reservoir into the patient. The method involves establishing fluid communication between the drug reservoir and the patient (i.e., the target site), and controlling the pump actuator. In particular, the actuator is controlled i) to initially deliver a substantially fixed dosage of the liquid over time (e.g., at periodic time intervals or in an aspect related to the invention , through continuous infusion) from the drug reservoir into the patient, and ii) to compensate for a change in a condition of the pump so as to maintain or resume the delivery of the substantially fixed dosage of the liquid over time (e.g., at the periodic time intervals or in an aspect related to the invention , through the continuous infusion) into the patient.

In various embodiments, the control circuitry includes memory for storing the conditions of the pump at the time of previous delivery events (e.g., at the time of each delivery interval). Moreover, the drug-delivery pump may include a flow sensor for measuring a flow rate of the liquid through the cannula and into the patient, and the circuitry may control the pump actuator based, at least in part, on an analysis of the flow rate. The circuitry may also control the actuator based on the stored conditions of the pump from the previous doses and/or on real-time data from the actuator.

As mentioned, the drug-delivery pump is an electrolysis-driven pump. More particularly, the pump actuator may include an electrolyte chamber, an expandable diaphragm that separates the electrolyte chamber from the drug reservoir and provides a fluid barrier therebetween, and electrolysis electrodes that cause evolution of a gas in the electrolyte chamber. The evolution of the gas expands the diaphragm so that the liquid is forced from the drug reservoir into the cannula. In various embodiments, the diaphragm expansion is adjusted by varying the actuation current supplied to the electrodes. In other embodiments, the diaphragm expansion is adjusted by varying an actuation duration of the electrodes. As described herein, the electrolysis electrodes may be driven with either a constant current or a time-varying current waveform.

In general, in yet another aspect, embodiments of the invention feature a drug- delivery pump that includes a drug reservoir, an electrolyte chamber, electrolysis electrodes, an expandable diaphragm that separates the electrolyte chamber from the drug reservoir and provides a fluid barrier therebetween, a cannula for conducting liquid from the drug reservoir to a target site, and circuitry for adjusting expansion of the diaphragm based on conditions of the target site (e.g., changes in one or more biochemical parameters of the target site, in electrical activity at the target site, and/or in pressure at the target site). The pump may include a sensor for detecting such conditions. For their part, the electrolysis electrodes may be activated to cause evolution of a gas in the electrolyte chamber, which expands the diaphragm so that the liquid is forced from the drug reservoir into the cannula.

These and other objects, along with advantages and features of the embodiments of the present invention herein disclosed, will become more apparent through reference to the following description, the accompanying drawings, and the claims. Furthermore, it is to be understood that the features of the various embodiments described herein are not mutually exclusive and can exist in various combinations and permutations, even if not made explicit herein.

Brief Description of the Drawings

In the drawings, like reference characters generally refer to the same parts throughout the different views. Also, the drawings are not necessarily to scale, emphasis instead generally being placed upon illustrating the principles of the invention. In the following description, various embodiments of the present invention are described with reference to the following drawings, in which: <ul id="ul0001" list-style="none"><li><figref idref="f0001">FIG. 1</figref> schematically illustrates, in cross-section, an implantable drug-delivery pump in accordance with one embodiment of the invention;</li><li><figref idref="f0002">FIG. 2</figref> schematically illustrates, in cross-section, an implantable drug-delivery pump in accordance with another embodiment of the invention;</li><li><figref idref="f0003">FIG. 3</figref> is a block diagram of a drug-delivery pump in accordance with one embodiment of the invention;</li><li><figref idref="f0004">FIG. 4</figref> is a graph representing an example of how each of the drug-delivery pumps depicted in <figref idref="f0001 f0002 f0003">FIGS. 1-3</figref> may adapt to changing conditions within the pump to deliver a target dosage level;</li><li><figref idref="f0005">FIG. 5A</figref> illustrates exemplary flow and actuation profiles of a pump that operates without feedback control;</li><li><figref idref="f0006">FIG. 5B</figref> illustrates exemplary flow and actuation profiles of a pump whose actuator is actuated for a longer period of time as the pump's efficiency decreases;</li><li><figref idref="f0007">FIG. 5C</figref> illustrates exemplary flow and actuation profiles of a pump whose actuation current is increased as the pump's efficiency decreases; and</li><li><figref idref="f0008">FIG. 6</figref> is a sectional view of a patient's eye illustrating implantation therein of a drug-delivery pump in accordance with one embodiment of the invention.</li></ul>

Description

In general, embodiments of the present invention pertain to external or implantable drug-delivery pumps (whether they be reusable and refillable pumps, disposable pumps, etc.) whose actuation may be dynamically and adaptively controlled. For example, embodiments of the drug-delivery pumps may be implantable within a patient's body, such as within the patient's eye or brain. In certain embodiments, the implantable drug-delivery pumps combine small size and a refillable drug reservoir. The small size minimizes discomfort from the drug-delivery pump to the patient, while the refillable reservoir allows the pump to be refilled in situ, rather than having to be replaced. As such, a fluid, such as a solution of a drug, can be supplied to the patient over extended periods of time.

A. Exemplary Drug-Delivery Pump

Embodiments of the invention may be employed in connection with various types of drug-delivery pumps, whether they be external pumps or pumps implantable within a patient's body. <figref idref="f0001">FIGS. 1</figref> and <figref idref="f0002">2</figref> schematically illustrate two variations of an exemplary implantable drug-delivery pump 100 (namely, an exemplary electrolytic or electrolysis-driven pump 100) implanted within a patient's eye 104. The pump 100 may, however, instead be implanted in other portions of a patient's body. For example, it may be implanted in the sub-arachnoid space of the brain to provide chemotherapy or to provide another type of treatment for the brain (e.g., by dosing the brain's parenchyma directly); near a tumor in any portion of the patient's body to provide chemotherapy; in a pancreas that does not respond well to glucose to provide agents (e.g., proteins, viral vectors, etc.) that will trigger insulin release; external to a patient but with a cannula placed under the skin or inside the abdominal cavity to deliver insulin; in the knee to provide drugs that will treat osteoarthritis or other cartilage diseases; near the spine to provide pain medications or anti-inflammatories; or elsewhere.

As illustrated in <figref idref="f0001">FIGS. 1</figref> and <figref idref="f0002">2</figref>, embodiments of the pump 100 may include two main components: a pair of chambers 108, 112 surrounded, at least in part, by a wall 115, and a cannula 120. As illustrated in <figref idref="f0001">FIG. 1</figref>, the wall 115 that surrounds the chambers 108, 112 may include or consist of a stand-alone parylene film 116 and, thereover, a separate protection shell 128 made of a relatively rigid biocompatible material (e.g., medical-grade polypropylene). Alternatively, as illustrated in <figref idref="f0002">FIG. 2</figref>, the wall 115 may correspond only to the protective shell 128, which may be coated with parylene.

The top chamber 108 defines a drug reservoir that, when being used to treat a patient, may contain the drug to be administered in liquid form. For its part, the bottom chamber 112 may contain a liquid that, when subjected to electrolysis, evolves a gaseous product. For example, that liquid may be water, which may be electrolytically separated by an applied voltage into hydrogen gas and oxygen gas. Alternatively, as other examples, the electrolyte liquid may be a saline solution (i.e., NaCl in H₂O) or a solution that contains either magnesium sulfate or sodium sulfate. In one embodiment, the two chambers 108, 112 are separated by a corrugated diaphragm 124. In other words, the diaphragm 124 provides a fluid barrier between the two chambers 108, 112. Like the stand-alone film 116, the diaphragm 124 may be constructed from, for example, parylene.

As illustrated in <figref idref="f0001">FIG. 1</figref>, the stand-alone film 116 may act as an outer barrier for the drug reservoir 108 and the protective shell 128 may provide a hard surface against which the film 116 exerts pressure. In such a case, the shell 128 may be perforated to allow for eye, brain, or other bodily fluid movement. Alternatively, as illustrated in <figref idref="f0002">FIG. 2</figref>, the protective shell 128 may itself act as the outer barrier for the drug reservoir 108 and be unperforated. In both embodiments depicted in <figref idref="f0001">FIGS. 1</figref> and <figref idref="f0002">2</figref>, the protective shell 128 may prevent outside pressure from being exerted on the drug reservoir 108. As illustrated in <figref idref="f0001">FIG. 1</figref>, a bottom portion 126 (i.e., a floor 126) of the protective shell 128 may include suture holes 130. Similarly, although not shown in either <figref idref="f0001">FIG. 1</figref> or <figref idref="f0002">FIG. 2</figref>, the cannula 120 may also include suture holes along its sides. The suture holes 130 may be employed in suturing (i.e., anchoring) the pump 100 in place in the patient's body.

As also illustrated in <figref idref="f0001">FIG. 1</figref>, to provide power to the pump 100 and to enable data transmission therewith, a battery and control circuitry 132 may be embedded (e.g., hermetically sealed) under the chambers 108, 112 (i.e., between a bottom portion of the stand-alone parylene film 116 of the drug reservoir 108 and the floor 126 of the protective shell 128), and an induction coil 136 may be integrated in the protective shell 128 (e.g., by injection molding). <figref idref="f0002">FIG. 2</figref> more clearly illustrates a hermetic case 135 for housing the battery and conventional control circuitry 132, but, for simplicity, does not depict the components housed therein. The hermetic case 135 may be made from biocompatible metals (e.g., titanium) or metal alloys. The bottom of the hermetic case 135 may be flat, or it may be concave to help the implantable pump 100 fit on the patient's eye 104.

In one embodiment, the induction coil 136 permits wireless (e.g., radio-frequency) communication with an external device (e.g., a handset). The handset may be used to send wireless signals to the control circuitry 132 in order to program, reprogram, operate, calibrate, or otherwise configure the pump 100. In one embodiment, the control circuitry 132 communicates electrically with electrolysis electrodes 134 in the electrolyte chamber 112 by means of metal interconnects (vias) 138 spanning a bottom portion of the electrolyte reservoir 112. The electrolysis electrodes 134 may be made from, for example, platinum, gold, and/or other metal(s). As further described below, the control circuitry 132 controls the pumping action of the pump 100, including the below-described closed-loop control process.

In one embodiment, as illustrated in <figref idref="f0001">FIG. 1</figref>, the cannula 120 connects the drug reservoir 108 to a check valve 140 inserted at the site of administration. The check valve 140 may be a one-way check valve that prevents the backflow of any fluid into the drug reservoir 108. Alternatively, or in addition, as illustrated in <figref idref="f0002">FIG. 2</figref>, the check valve 140 may be integral with and located at a proximal end of the cannula 120 (i.e., at the end closest to the drug reservoir 108). More generally, however, the check valve 140 may be located anywhere along the cannula 120. In addition, one or more flow sensors 144 for monitoring the flow of the drug, and thereby enabling the measurement of the drug volume delivered and/or the flow rate of the drug through the cannula 120, may be associated with one or more of a proximal, middle, or distal portion of the cannula 120. Optionally, as illustrated in <figref idref="f0001">FIG. 1</figref>, one or more target site sensor(s) 148 may also be integrated at a distal end of the cannula 120 (i.e., at the end furthest from the drug reservoir 108) in order to measure one or more parameters at the site of administration (e.g., the intravitreal chamber, shoulder capsule, knee capsule, cerebral ventricals, spinal canal, etc.). For example, the target site sensor(s) 148 may be employed to sense one or more of a change in a biological or biochemical parameter at the target site (e.g., a change in a specific analyte concentration, the presence or absence of a specific biochemical marker, etc.), a change in electrical activity at the target site (which may, for example, be brought on by a physiological change), and a change in pressure at the target site. In one embodiment, the target site sensor(s) 148 provide feedback (i.e., real-time measurements) to the control circuitry 132 so that the flow of drug may be metered by a closed-loop control process. For example, increased pressure in the drug target region may warrant a decrease in the flow of drug from the pump 100.

As illustrated in <figref idref="f0001">FIG. 1</figref>, the cannula 120 may be an extension of the stand-alone parylene film 116. Alternatively, as illustrated in <figref idref="f0002">FIG. 2</figref>, the cannula 120 may be a separate component (e.g., a parylene component) that is coupled to the protective shell 128. For example, a proximal end of the cannula 120 may be inserted through a fluid connection port formed in the protective shell 128 and bonded thereto by way of, e.g., a biocompatible epoxy glue 150. A silicone sheath 154 may be placed around a portion of the cannula 120 (see <figref idref="f0002">FIG. 2</figref>), but this is optional (see <figref idref="f0001">FIG. 1</figref>).

In one embodiment, as illustrated in <figref idref="f0001">FIG. 1</figref>, a fill port 152 is assembled with the drug reservoir 108 and sealed by a sealant (e.g., a biocompatible epoxy) 156 to the stand-alone film 116 and protective shell 128. In yet another embodiment, as illustrated in <figref idref="f0002">FIG. 2</figref>, a hole may be formed through the protective shell 128 and the fill port 152 featured therein. In still another embodiment, the fill port 152 may be formed elsewhere on the pump 100 and be connected to the drug reservoir 108 through tubing. For example, the fill port 152 may be molded from biocompatible materials, coupled to a matching notch on the hermetic case 135, and connected to the drug reservoir 108 through the tubing. In one embodiment, the tubing is inserted through a fluid connection port formed in a wall surrounding the drug reservoir 108 and bonded thereto by way of a biocompatible epoxy glue. In either case, the fill port 152 is in fluid communication with the drug reservoir 108 and permits an operator of the pump 100 (e.g., a physician) to refill the drug reservoir 108 in situ (e.g., while the pump 100 is implanted within the patient's eye 104). In general, the drug reservoir 108 can be refilled by inserting a refill needle into and through the fill port 152.

In various embodiments, the main parts of the pump 100 (i.e., the pair of chambers 108, 112 and the cannula 120) are amenable to monolithic microfabrication and integration using multiple parylene layer processes. The fill port 152, the protective shell 128, and other components may be assembled with the pump 100 after the microfabrication steps.

In operation, when current is supplied to the electrolysis electrodes 134, the electrolyte evolves gas, expanding the corrugated diaphragm 124 (i.e., moving the diaphragm 124 upwards in <figref idref="f0001">FIGS. 1</figref> and <figref idref="f0002">2</figref>) and forcing liquid (e.g., drug) out of the drug reservoir 108, into and through the cannula 120, and out the distal end thereof to the targeted site of administration. The corrugations or other folds in the expandable diaphragm 124 permit a large degree of expansion, without sacrificing volume within the drug reservoir 108 when the diaphragm 124 is relaxed. When the current is stopped, the electrolyte gas condenses back into its liquid state, and the diaphragm 124 recovers its space-efficient corrugations.

B. Adaptive Control Based Upon Internal Pump Conditions

In general, the response of the electrolysis-driven pump 100 to a given input current supplied to the electrolysis electrodes 134 depends on how much liquid is remaining in the drug reservoir 108. For example, if the drug reservoir 108 is nearly empty, more current is needed to bring the drug reservoir 108 to its "full" configuration before pressure can begin to build up and pumping can commence. On the other hand, if the drug reservoir 108 is completely full, very little current is needed before delivery of the drug begins. Similarly, the response of the electrolysis-driven pump 100 to a given input current also depends on the gas/liquid ratio in the electrolysis chamber 112. In particular, the response of the pump 100 will be very different when the drug reservoir 108 is full with drug (e.g., when the electrolysis chamber 112 operates with a low gas/liquid ratio) than when the drug reservoir 108 is nearly empty (e.g., when the electrolysis chamber 112 operates with a high gas/liquid ratio). In addition, other factors can cause the response of the electrolysis-driven pump 100 to change over time including, for example, degradation of the electrolysis electrodes 134, changes in the concentration of the electrolyte in the electrolysis chamber 112, changes in the flow characteristics of the check valve 140, and restrictions that form at the output of the cannula 120 due to tissue growth or some other mechanism.

Because of these factors, the electrolysis pump 100 is inherently variable. Accordingly, adaptive control in accordance herewith can confer substantial advantages upon the pump 100. For example, as further explained below, by analyzing previous doses to ascertain how the pump 100 responded to given input currents, the optimal settings (e.g., the settings which give the most accurate and shortest dose) for the current dose can be derived. This can be particularly beneficial when the dose volume is small compared to the volume of the drug reservoir 108. In such a situation, the state parameters of the pump 100 (e.g., the drug volume remaining in the drug reservoir 108, the liquid/gas ratio in the electrolysis chamber 112, the condition of the electrodes 134, the characteristics of the check valve 140, etc.) are nearly identical from one dose to the immediately following dose, and, as such, the previous doses are an excellent predictor for the current dose.

<figref idref="f0003">FIG. 3</figref> is a block diagram of a drug-delivery pump 200 that depicts the control circuitry 132 in greater detail. The drug-delivery pump 200 may be any type of external or internal pump having an actuator 204 that forces the liquid from the drug reservoir 108 into and through the cannula 120. The drug-delivery pump 200 is an electrolysis-driven pump and, with reference to <figref idref="f0001">FIGS. 1</figref> and <figref idref="f0002">2</figref> described above, the pump actuator 204 may include the electrolyte chamber 112, the expandable diaphragm 124, and the electrolysis electrodes 134. For its part, the control circuitry 132 includes computer memory 208 for storing one or more conditions of the pump 200, and an adaptive controller 212 for controlling the pump actuator 204 based on a change in a condition of the pump 200. Optionally, the control circuitry 132 may also include one or more module(s) to convert raw data received from the flow sensor 144 into a meaningful value (e.g., into a flow rate in nL/min) and/or to convert similarly raw data received from the pump actuator 204 into a meaningful value. Alternatively, the functions performed by such module(s) may instead be performed by the adaptive controller 212.

The computer memory 208 may be implemented as any type of volatile or nonvolatile (e.g., Flash) memory, while the adaptive controller 212 and/or the module(s) described above may each be implemented as any software program, hardware device, or combination thereof that is capable of providing the functionality described herein. For example, the adaptive controller 212 and/or the module(s) described above may each be an application-specific integrated circuit (ASIC) or a field-programmable gate array (FPGA). Alternatively, the adaptive controller 212 may be implemented using a general-purpose microprocessor (e.g., any of the PENTIUM microprocessors supplied by Intel Corp.) that is programmed using any suitable programming language or languages (e.g., C++, C#, Java, Visual Basic, LISP, BASIC, PERL, etc.). Suitable control programming is straightforwardly implemented by those of skill in the art without undue experimentation.

In one particular embodiment, as further described below, the control circuitry 132 is programmed to deliver a fixed dosage of the drug from the drug reservoir 108 to the target site at periodic time intervals, and is configured to store the conditions of the pump 200 at each of those time intervals in the computer memory 208. Some exemplary and non-limiting conditions internal to the pump 200 that may be stored at each dosing interval (or at other periodic intervals) include the current through, voltage across, or resistance of the electrolysis electrodes 134; the total electrical charge used to drive the electrolysis electrodes 134; the maximum flow rate of the drug through the cannula 120; any variations in flow patterns of the drug through the cannula 120; the actuation time required for the pump 200 to achieve a particular flow rate of the drug through the cannula 120; the time required for the flow of drug to ramp down from a particular flow rate to a flow rate of zero; the time delay between the initial actuation of the pump 200 and the initial flow of drug through the cannula 120; the efficiency of the pump actuator 204 (which, in the case of an electrolysis-driven pump 200, may be defined as the ratio between the amount of charge pumped through the actuator 204 and the amount of gas generated thereby); the internal pressure of the drug reservoir 108; the acceleration experienced by the pump 200; flow sensor parameters particular to the flow sensor 144 architecture (e.g., where the flow sensor 144 is a resistive temperature detector, the resistance of the sensor and heater elements may be stored); and the physical dimensions of the pump actuator 204, the drug reservoir 108, and/or the cannula 120, which may change due to blockages, scarring, or other biochemical/physiological events.

In one embodiment, these parameters are measured either directly or indirectly by using physical sensors, such as, for example, the flow sensor(s) 144, pressure sensors in the drug reservoir 108 or cannula 120, accelerometers, gyroscopes, altimeters, sensors in proximity to the electrolysis electrodes 134 (to measure, for example, their resistance, the current passing therethrough, and/or the voltage thereat or thereacross), or any other sensor dispersed throughout the pump 200. In other embodiments, these parameters are determined by using known relationships. For example, the flow rate of the drug through the cannula 120 may be determined by using a pressure sensor in the cannula 120 and by utilizing the well-known linear relationship between pressure and flow rate. In still other embodiments, many of these parameters may ascertained by analyzing the electrical waveforms used to drive the pump actuator 204, and/or by analyzing the flow profiles sensed by the flow sensor(s) 144.

In all cases, as further described below, the adaptive controller 212 of the control circuitry 132 can receive and process this parameter data and compensate for any change in a condition of the pump 200 in order to adjust its operation to maintain a target dosage level. This "self-compensation" may be achieved by storing, as mentioned above, parameter data from the pump 200 state at the time of the previous dosages and by considering real-time parameter values to determine the optimal actuation current for the electrolysis electrodes 134 and/or their actuation duration at the next dosing event. For example, as illustrated in <figref idref="f0003">FIG. 3</figref>, the adaptive controller 212 may receive, analyze, and process the stored parameters from previous doses, real-time data from the pump actuator 204, and real-time data from the flow sensor(s) 144 (e.g., flow rate data) to ascertain and direct appropriate output signals to the pump actuator 204 (i.e., in order to drive the pump 200 in the appropriate manner). For initial dosing, or in cases where the above-described data may be unavailable (e.g., due to a reset action in the pump 200), the adaptive controller 212 may employ a set of pre-defined reference parameter values. These reference values may be specific to the characteristics of the particular pump 200 employed, for example specific to the types of electrolysis electrodes 134 employed, the type of electrolytic solution used, and/or the physical dimensions of the pump actuator 204, drug reservoir 108, and cannula 120.

In one mode of operating an electrolysis-driven pump 200, the electrolysis electrodes 134 are driven using a constant current for a variable amount of time. In this mode, the constant current results in a monotonic rise in the flow rate of the drug through the cannula 120 until the current is shut off, at which point the residual pressure in the pump 200 gives rise to a slow decay in the flow rate until the flow rate reaches zero. In one functional example for this mode of operation, the following three parameters are stored in the computer memory 208 at each dosing interval: the current supplied to the electrolysis electrodes 134 in order to drive the pump 200 (I); the maximum flow rate of the drug through the cannula 120 (F_max); and the volume of liquid (i.e., drug) that is delivered by the pump 200, due to residual pressure, after the pump actuator 204 is deactivated (V_shutoff). This stored information is then used, in future doses, to improve the dosing speed and accuracy. For example, the current used to drive future doses may be adjusted based on previous dose data (e.g., increased if the maximum flow rate is too low, and decreased if the maximum flow rate is too high) in order to keep the duration of each dose, and the volume of the drug delivered on each dose, relatively consistent. In one embodiment, this is done in a linear fashion as follows: <maths id="math0001"><math display="block"><mrow><msub><mi mathvariant="bold">I</mi><mi>current</mi></msub><mo>=</mo><msub><mi mathvariant="bold">F</mi><mi>optimal</mi></msub><mo>/</mo><msub><mi mathvariant="bold">F</mi><mrow><mi>max</mi><mo>,</mo><mi>previous</mi></mrow></msub><mo>×</mo><msub><mi mathvariant="bold">I</mi><mi>previous</mi></msub></mrow></math><img file="EP2467797B1_D0001.tif" /></maths> where I_current is the current to be supplied to the electrolysis electrodes 134 during the current dose, F_optimal is the desired maximum flow rate of the drug through the cannula 120, F_max,_previous was the maximum flow rate of the drug through the cannula 120 during the previous dose, and I_previous was the current supplied to the electrolysis electrodes 134 during the previous dose.

As another example, the shut-off time of the pump actuator 204 may instead, or in addition, be adjusted (e.g., shut off later if the volume of the liquid delivered after the pump actuator 204 is deactivated is lower than expected, and shut off earlier if the volume of the liquid delivered after the pump actuator 204 is deactivated is higher than expected) in order to keep the volume of the drug delivered relatively consistent. Once again, this may be done using a linear approximation, where the pump actuator 204 is deactivated as soon as the following condition is met: <maths id="math0002"><math display="block"><mrow><msub><mi mathvariant="bold">V</mi><mi mathvariant="normal">accumulated</mi></msub><mo>+</mo><mi mathvariant="bold">F</mi><mo>/</mo><msub><mi mathvariant="bold">F</mi><mrow><mi mathvariant="normal">max</mi><mo>,</mo><mi mathvariant="normal">previous</mi></mrow></msub><mo>×</mo><msub><mi mathvariant="bold">V</mi><mrow><mi mathvariant="normal">shutoff</mi><mo>,</mo><mi mathvariant="normal">previous</mi></mrow></msub><mo>=</mo><msub><mi mathvariant="bold">V</mi><mi mathvariant="normal">target</mi></msub></mrow></math><img file="EP2467797B1_D0002.tif" /></maths> where V_accumulated is the total volume of the drug delivered so far in the current dose, F is the real-time flow rate of the drug through the cannula 120, F_max,_previous was the maximum flow rate of the drug through the cannula 120 from the previous dose, V_shutoff,_previous was the volume of the drug delivered after the pump actuator 204 was shut off in the previous dose, and V_target is the target volume of the drug to be delivered. In this manner, the adaptive controller 212 constantly adjusts the way in which the pump 200 is actuated, and accounts for systematic, non-random changes in the pump 200 characteristics.

Determining and controlling both the amount of current needed to initiate the flow of drug through the cannula 120 and then to reach a particular flow rate, as well as the amount of liquid delivered from the drug reservoir 108 after the current is no longer applied to the electrolysis electrodes 134, is of particular benefit when the pump 200 is an electrolysis-driven pump. In particular, the first parameter is important because the amount of current needed to initiate the flow of drug through the cannula 120 and to reach a particular flow rate depends on how much liquid is left in the drug reservoir 108. Using too low a current would be power-inefficient, since all systems would be running even though there would be no or very low flow of drug through the cannula 120. On the other hand, using too high a current could cause the flow rate of the drug to overshoot to unsafe levels. The second parameter is also of importance since the volume of drug delivered after the pump 200 is turned off is dependent primarily on the gas/liquid ratio in the electrolysis chamber 112. For doses later in the life-cycle of the pump 200 (e.g., where the pump 200 runs with a high gas/liquid ratio in the electrolysis chamber 112), there is much more gas that needs to be dissipated before the pump 200 can fully stop. The opposite is true for earlier doses.

As will be understood by one of ordinary skill in the art, in addition to the two examples given above, the adaptive controller 212 may recognize and analyze numerous other changes in conditions internal to the pump 200 when controlling the pump actuator 204 and, ultimately, the dispensing of the drug from the drug reservoir 108. For example, there may be situations where is it desirable for the pump 200 to reach an optimal flow rate (F_optimal) for each dose in a specified period of time (t_optimal) and to then maintain that flow rate for the remainder of the dose. One way to achieve this is to begin each dose by using a constant current (I_starting) to drive the electrolysis electrodes 134 of the pump 200 until the optimal flow rate (F_optimal) is reached, at which point feedback from the flow sensor 144 and an algorithm (e.g., a proportional-integral-derivative ("PID") algorithm or another algorithm) may be used to adjust the current supplied to the electrolysis electrodes 134 to maintain that optimal flow rate (F_optimal) for the remainder of the dose. In other words, the pump 200 may be driven using a time-varying current waveform. In one embodiment, in order to achieve the optimal flow rate (F_optimal) in the specified period of time (t_optimal), the starting current (I_starting) is adjusted from dose to dose. In a manner similar to before, this can be done, for example, using a linear approximation (although, as will be understood by one of ordinary skill in the art, non-linear approximations may also be employed for any of the parameters derived herein). More specifically, the starting current for the current dose (I_{starting,current}) can be calculated using the starting current from the previous dose (I_{starting,previous}) and the time it took for the flow rate to reach the optimal flow rate (F_optimal) in the previous dose (t_previous), as follows: <maths id="math0003"><math display="block"><mrow><msub><mi mathvariant="bold">I</mi><mrow><mi mathvariant="normal">starting</mi><mo>,</mo><mi mathvariant="normal">current</mi></mrow></msub><mo>=</mo><msub><mi mathvariant="bold">t</mi><mi mathvariant="normal">previous</mi></msub><mo>/</mo><msub><mi mathvariant="bold">t</mi><mi mathvariant="normal">optimal</mi></msub><mo>×</mo><msub><mi mathvariant="bold">I</mi><mrow><mi mathvariant="normal">starting</mi><mo>,</mo><mi mathvariant="normal">previous</mi></mrow></msub></mrow></math><img file="EP2467797B1_D0003.tif" /></maths>

Referring now to <figref idref="f0004">FIG. 4</figref>, an exemplary graph 300 illustrating the effects of the above-described adaptive control on the drug dosage level is depicted. In this example, the target dosage level to be delivered during each release event is 200 nanoliters (nL). Event 1 corresponds to an initial dosing of 180 nL based on calculations using the reference parameter values. The adaptive controller 212 then calculates appropriate adjustments to the pump 200 parameters (e.g., as described above, the amount of current supplied to the electrolysis electrodes 134 and/or the actuation time thereof may be increased in order to increase the volume of drug delivered to the target site) until a target delivery of 200 nL is achieved at Event 2. As illustrated, there may be a point 304 in time between Event 1 and Event 2 during which the adaptive controller 212 overcompensates and the pump 200 delivers more than the target dosage (e.g., 205 nL). In this case, the adaptive controller 212 refines its adjustments to the pump 200 parameters (e.g., as described above, the amount of current supplied to the electrolysis electrodes 134 and/or the actuation time thereof may be decreased in order to decrease the volume of drug delivered to the target site) until the target delivery of 200 nL is in fact achieved at Event 2.

Continuing with the example depicted in the graph 300 of <figref idref="f0004">FIG. 4</figref>, the dosage at Event 3 then drops to 190 nL due to a change in one or more of the pump 200 parameters. Exemplary conditions within the pump 200 itself that may change and lead to such a decrease in the dosage of the drug delivered (i.e., to a decrease in the efficiency of the pump 200) can include the degradation (e.g., erosion or corrosion) of the electrolysis electrodes 134, a decrease in the concentration of the electrolytes in the solution present in the electrolysis chamber 112, and/or general mechanical or chemical wear. In response, the adaptive controller 212 then compensates as described above so that the pump 200 releases the correct amount of drug at Event 4. The pump 200 thus dynamically reacts to changing conditions of the pump 200.

<figref idref="f0005">FIG. 5A</figref> depicts exemplary flow profiles 400 and actuation profiles 404 for a pump that operates without the feedback control provided by the control circuitry 132 (e.g., for a pump employing an open-loop control system). As shown, the amount of drug delivered at later times decreases even though the actuation current remains the same (the actuation profiles 404 for the earlier and later doses overlap in <figref idref="f0005">FIG. 5A</figref>), due to decreasing pump efficiency.

<figref idref="f0006">FIG. 5B</figref> depicts exemplary flow profiles 408 and actuation profiles 412 for a pump 200 that operates with the feedback control provided by the control circuitry 132. In particular, <figref idref="f0006">FIG. 5B</figref> shows how increasing the pumping time for a later dose can compensate for reduced pump 200 efficiency. More specifically, for the later dose, the pump 200 actuates for a longer period of time at the same current in order to successfully deliver the target dosage amount.

<figref idref="f0007">FIG. 5C</figref> also depicts exemplary flow profiles 416 and actuation profiles 420 for a pump 200 that operates with the feedback control provided by the control circuitry 132. In particular, <figref idref="f0007">FIG. 5C</figref> shows how the dosing time for the earlier and later doses can be kept constant while still compensating for decreased pump 200 efficiency by increasing the actuation current of the later dose. The flow profiles 416 for the earlier and later doses overlap, illustrating that the same amount of drug is delivered during both dosages.

C. Adaptive Control Based Upon Conditions of the Target Site

In other embodiments, with reference again to <figref idref="f0001 f0002 f0003">FIGS. 1-3</figref>, the adaptive controller 212 can also receive information from the target site sensor(s) 148 that monitor the drug-delivery treatment area, and thereafter change the target dosage for certain time periods. More particularly, if changes in the treatment area (e.g., worsening or improvement of symptoms, changes in biological or biochemical parameters, changes in electrical activity, changes in pressure, etc.) require a higher or lower dosing level or a change in the frequency of dosages, the adaptive controller 212 can control the pump actuator 204 so as to adjust the dosage and maintain it at a new level until another change is required. In other words, the adaptive controller 212 may actuate the pump 200 to achieve a desired result, such as the regulation of a specific physiological state or biochemical parameter. As before, the parameters sensed by the target sensor(s) 148 (e.g., pressure, temperature, etc.) may be stored in the computer memory 208 for later use (e.g., for comparison in determining the appropriate dosage of drug to be delivered).

As an example, assume that the pump 200 delivers an initial target dosage of 200 nL every 30 minutes. After a period of time, either due to a change in the treatment area or dosing regimen, the dosage may need to be decreased to 150 nL. The adaptive controller 212 may then operate the pump actuator 204 so as to deliver 150 nL of the drug every 30 minutes until instructed otherwise, either by another change in the treatment area or by a user of the pump 200.

Advantageously, this flexibility facilitates the use of the pump 200 with a wide range of treatment regimens that may require the staggering of different dosages or dosage frequencies over prolonged periods of time.

Optionally, the adaptive controller 212 may be programmed to respond to both a change in a condition of the pump 200 itself and, at the same time, to a change in condition of the target treatment area. In other words, the adaptive controller 212 may receive data from both sensors or other devices internal to the pump 200 and from the target site sensor(s) 148, analyze both sets of data, and control the pump actuator 204 to account for both sets of data. Alternatively, in another embodiment, if the deterministic parameters are to be those of the pump 200 itself rather than those of the treatment area, the adaptive controller 212 may be programmed to refrain from initiating actions based on, for example, blockages that may form within the target area due to physiological changes or scarring.

D. Exemplary Uses of the Dynamic, Adaptively Controlled Drug-Delivery Pumps

<figref idref="f0008">FIG. 6</figref> schematically illustrates a drug-delivery pump 100, 200 implanted in the eye of a patient in accordance with one embodiment of the invention. As illustrated, the pump 100, 200 is placed upon the conjunctiva of the eye, and a distal end of the cannula 120 is inserted therethrough in to the posterior chamber of the eye. As such, the distal end of the cannula 120 (and, hence, the drug reservoir 108) is in fluid communication with the patient. The drug-delivery pump 100, 200 then administers a therapeutic liquid to the posterior chamber of the eye through the cannula 120 and the check valve 140, which, as previously mentioned, may be employed to prevent the backflow of the liquid. In particular, the pump actuator 204 may be controlled through use of the adaptive controller 212 and the other control circuitry 132 in any of the manners described hereinabove (e.g., based on a change in a condition of the pump itself and/or based on conditions of the target site) so as to deliver one or more dosages of the liquid from the drug reservoir 108, through the cannula 120, and into the patient's eye.

In other embodiments, the pump 100, 200 is used to administer the liquid to the anterior chamber of the eye, which is separated from the posterior chamber by the lens. More generally, however, the pump 100, 200 may, as previously mentioned, be employed to administer liquid to any portion of the patient's body.

As an additional example, the pump 100, 200 may be a body-adhered electrolysis-driven pump for the infusion of medication into a patient's subcutaneous tissue. For example, the pump 100, 200 may continuously deliver insulin to the patient's body over three to seven days. A patient may need, however, to recalculate his or her insulin delivery (e.g., increase or decrease basal rates over time), as well as program the pump 100, 200 to give an intermittent bolus spike of insulin after a meal. Accordingly, the pump 100, 200 in this example can adapt the electrolysis to increase or decrease the flow of insulin to accurately deliver the correct fluidic volumes over time. Furthermore, infusion of a drug over an extended period of time, such as three days, may subject the pump 100, 200 to new environmental conditions. For example, a patient may drive from low to high altitudes or fly in a pressurized plane. The pump 100, 200 can use both environmental signals (e.g., altimeter, pressure change, flow rate change, etc.) to adjust the flow of the drug and to ensure the accurate delivery of the drug.

As yet another example, the pump 100, 200 may use input from an accelerometer or gyroscope in order to sense a patient's position. For example, the pump 100, 200 may sense that the patient was horizontal during the hours of 10pm to 6am for the previous 7 days (because, for example, the patient was sleeping). In this case, the pump 100, 200 may then recognize the patient's sleep time (i.e., from sensing the patient to be in a horizontal position) or REM sleep cycle and then use that information to infuse a different volume of drug (or drug at specific times) to accommodate optimal conditions. For example, the flow rate of the pump 100, 200 may be adjusted to an amount pre-prescribed by a physician for infusion during sleep (e.g., it is often best to inject some glaucoma medications to a patient's eye during REM sleep cycle in order to better distribute the medication throughout the eye, while some medications such as Anti-VEGF drugs for the retina act over a period of a month and should be injected calmly into the vitreous; in addition, a lower basal rate of insulin or less pain medication may be injected during sleep). In contrast to understanding when a patient is sleeping, the pump 100, 200 may also recognize when the patient is exercising or when the patient is not supine, and adjust its infusion of drug accordingly (e.g., such as to that which is pre-programmed by the physician for infusion during certain activities).

Advantageously, the control circuitry 132 described herein can be employed for pumps that are not uniform in their characteristics, either due to user-selected preferences or variations arising during the manufacturing process. The types of electrodes and electrolytic solution used, for example, determine the performance of electrolysis-driven pumps. The control circuitry 132 is, however, robust and versatile enough to accommodate pumps that operate across a wide range of parameter values. As another example, manufacturing process variations in the resistance of the flow sensor elements can be mitigated by the adaptive nature of the control circuitry 132. More specifically, mismatched resistances in the flow sensor elements resulting from the process variations will result in an offset for which the control circuitry 132 can compensate.

Optionally, the control circuitry 132 may also serve to enhance safety and efficacy of the pump 100, 200 by monitoring certain key pump parameters. For example, acceptable ranges may be defined for each parameter or for some overall combination of parameters corresponding to a specific pump state, during which the pump 100, 200 continues to operate normally. Should an individual parameter or some combination of parameters not fall within these pre-defined ranges, an action may then be triggered within the pump 100, 200, such as shutting off or alerting the user that a response is required. For example, the pump 100, 200 may alter a patient by illumination, sound, vibration, or shock. In one embodiment, the alert is programmed to occur when the patient is moving to maximize the likelihood that the patient will receive the alert and also to conserve battery power by avoiding alerts while the patient is sleeping.

In one particular example, the control circuitry 132 can respond to and predict the failure of a flow sensor 144. Where, for example, the flow sensor 144 includes a group of heaters and resistive temperature detectors, one of its elements may begin to fail after an indeterminate number of doses due to thermal stresses experienced during its use. The control circuitry 132 can monitor the resistance of the heater elements periodically (e.g., from dose to dose) and detect changes in resistance that may indicate the start of failure or outright failure (such as an open-circuit). Other pump components including sensors and actuators that employ resistive or capacitive elements can likewise be monitored by the control circuitry 132 to ensure proper functional operation.