Nova Patents
EP2360184A3

Antibodies that bind human interleukin-18 and methods of making and using

Abstract

Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

Term

Term ended

Projected expiry passed 9 February 2021, 5.6 years ago.

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Every citation, both waysCites: the store holds 5 of 6

Citations
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EP0974600A2CitesEuropean Patent Office (EPO)ISearch report1-28
WO2005019270A2CitesWorld Intellectual Property Organization (WIPO)ESearch report12,15-19
WO9744468A1CitesWorld Intellectual Property Organization (WIPO)ISearch report1-28
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