Stent designed for the delivery of therapeautic substance or other agents

0001The present invention relates to a system for delivering substances into a body.

BACKGROUND OF THE INVENTION

0002Stents are used for a variety of medical purposes in the body including in the coronary arteries, the peripheral arteries, arteries of the neck, cerebral arteries, veins, biliary ducts, urethras, ureters, fallopian tubes, bronchial tubes, the trachea, the esophagus and the prostate. Stents are typically placed or implanted within a bodily vessel, for example, for treating stenoses, strictures or aneurisms therein. They are implanted to reinforce collapsing, partially occluded, weakened, or dilated sections of a blood vessel.

0003Stents are typically available in self-expanding configuration and mechanically expandable configuration. Hybrid stents which are self-expanding in part and mechanically expandable in part are also available.

0004Many stents are manufactured with struts having a zig-zag or serpentine configuration which resembles that of a sine wave. An example of a serpentine portion of a stent is shown at 104 in <figref idref="f0005">Figure 4a</figref>. Serpentine portion 104 extends about the circumference of the stent and includes a plurality of turns 105 which extend between adjacent struts. The individual struts are oriented at an angle 01 relative to longitudinal axis 101 of the stent. When a stent comprising one or more of serpentine portions 104 is radially expanded from an unexpanded state to an expanded state, as shown in <figref idref="f0005">Figure 4b</figref>, the angle 02 of the struts increases relative to the longitudinal axis and the effective strut length decreases from L to L-AL resulting in foreshortening of the stent.

0005Foreshortening of stents during deployment, however, is undesirable, as it reduces the placement accuracy of the stent. There remains a need for innovative stents which do not foreshorten upon expansion.

0006Further, it is often desirable to deliver drugs into a patient's body to treat medical conditions. In particular, a variety of drug therapies are available for treating the coronary system, either alone or in combination with more invasive procedures.

0007Such therapies may include delivering substances, such as nitroglycerin, epinephrin, or lidocaine, endocardially or into the pericardial space to treat the coronary system. In addition, heparin, hirudin, ReoPro or other anti-thrombotic compounds may be infused into blood vessels associated with the coronary system, such as occluded coronary arteries, or elsewhere in the cardiovascular system. More recently, gene therapy, e. g. introducing genetic material, and growth factor therapy, e. g. introducing proteins, cells or vectors including angiogenic growth factors, have been demonstrated to provide potential benefits in treating ischemic heart tissue and other regions of the coronary system, for example, by stimulating growth of neovascular conduits, which may evolve into blood vessels.

0008Various methods have been used to introduce drugs into the vasculature including, for instance, infusion catheters which may be optionally equipped with either a porous perfusion balloon, and/or with an electrode and/or heating element to improve localized delivery for continuous or intermittent delivery, ionophoresis in which a first electrode may be provided within a perfusion balloon, and a second electrode provided on an external region of the patient's body near the artery, embedding or depositing a drug on a catheter wail, a non-porous balloon wall on the catheter and/or a coating on the catheter, and so forth.

0009Another method of drug delivery has been to employ a stent. <patcit id="pcit0001" dnum="US6258121B"><text>US 6258121</text></patcit> describes, for example, a stent having a polymeric coating for controllably releasing an included active agent.

0010Documents <patcit id="pcit0002" dnum="US6254632B"><text>US 6254632</text></patcit> and <patcit id="pcit0003" dnum="WO0117577A"><text>WO 01/17577</text></patcit> describe stents comprising serpentine portions extending about the circumference of the stent, each serpentine portion having a plurality of turns and struts extending therebetween, and connectors connecting the serpentine portions, wherein at least some of said struts have a plurality of shaped recesses thereon, said recesses being smaller in dimension than said struts.

0011Without limiting the scope of the invention, a brief summary of the invention is set forth, below. Additional details of the summarized embodiments of the invention and/or additional embodiments of the invention may be found in the Detailed Description of the Invention below,

BRIEF SUMMARY OF THE INVENTION

0012The present invention is directed to a stent according to claim 1.

0013In one embodiment, the struts may have a wave-like pattern.

0014The struts have at least one shaped recess between the crest of a first side and the trough of a second side which align. Preferably, each aligning crest of the first side and trough of the second side will have a shaped recess as will the adjacent struts. The shaped recesses may be used to hold therapeutic agents which, are then delivered via the stent to the point of release. Desirably, shaped recesses may be located between every crest of the first side and trough of the second side of the strut, as well as on adjacent struts. This particular configuration allows for a maximum amount of drug delivery without sacrificing the strenght of the stent.

0015The shaped recesses may be of any geometric shape or pattern and in some embodiments the shaped recesses are elongated ellipsoids or substantially circular shapes.

0016In another embodiment, the invention is directed to a stent comprising a serpentine portion extending about the circumference of the stent. The serpentine portion has a first end with a plurality of turns and a second end with a plurality of turns and struts extending therebetween. Each of the struts of the serpentine portion has shaped recesses which do not extend all the way therethrough, but rather which are enclosed on three sides and open on the top, The shaped recesses are smaller in dimension than the struts.

0017Desirably, the stent comprises a plurality of serpentine portions extending about the circumference of the stent, each of which has a plurality of turns at the first and second ends.

0018In accordance with the invention, the struts may assume a regular shape or an irregular shape.

0019The inventive stents disclosed herein may be provided in embodiments in which the number of shaped recess per serpentine portion varies along the length of the stent. Desirably, at least one serpentine portion at one end and, more desirably, both ends of the stent will have more shaped recesses than any of the serpentine portions in the intermediate section, of the stent.

0020The inventive stents disclosed herein may also be provided in embodiments in which the size of shaped recessesin the serpentine portions varies along the length of the stent. Desirably, at least one serpentine portion at one end and, more desirably, both ends of the stent will have larger shaped recesses than any of the serpentine portions in the intermediate section of the stent.

0021The inventive stents may also be provided in embodiments in which the shaped recesses are characterized by a first width when the stent is in an unexpanded configuration and by a second width when the stent is in an expanded configuration, the second width greater than the first width.

0022Typically, the shaped recesses of the inventive stents will be arcuate when the stent is in the unexpanded state although shaped recesses of other shapes are also disclosed herein.

0023The shaped recesses may be of any geometry. In some embodiments, the shaped recesses are substantially circular, or are ellipsoids.

0024In some embodiments of the present invention, the stent is of a typical stent geometry having connectors and struts forming the framework of the stent, The stent framework further has shaped recesses which provide a reservoir for holding a substance or drug to be delivered within the body of a patient. The shaped recesses may be of various configurations or geometries, and may be of varying depth and size, i. e. width and length or circumference, Furthermore, the number of shaped recesses located in the framework of the stent may also be varied. In this embodiment, the stents are designed to deliver substances or drugs to target locations within a person's body, More particularly, in some embodiments the stent is designed to deliver substances or drugs within the vasculature of a patient such as therapeutic agents including, but not limited to, genetic material, growth factors, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, and antiallergenic substances, and so on and so forth, as well as combinations thereof. The present invention allows the substances to be deposited directly at targeted locations within the body or directly to selected tissue regions within the body.

0025Additional details and/or embodiments of the invention are discussed below.

BRIEF DESCRIPTION OF THE DRAWING(S)

0026<ul id="ul0001" list-style="none"><li><figref idref="f0001 f0002">Fig. 1</figref> a is a detail of a portion of a stent showing a strut not according to the present invention.</li><li><figref idref="f0001">Fig. 1b</figref> is the same detail of a portion of the stent of <figref idref="f0001">Fig. 1a</figref> in an expanded state.</li><li><figref idref="f0003">Fig. 2a</figref>. is an embodiment of a detail of a portion of a stent similar to that in <figref idref="f0001 f0002">Fig. 1</figref> a having shaped recesses thereon,</li><li><figref idref="f0003">Fig. 2b</figref> is a detail of a portion of the stent structure as shown in <figref idref="f0003">Fig. 2a</figref> in an expanded state.</li><li><figref idref="f0004">Fig. 3</figref> a is an alternative embodiment of the stent portion as shown in <figref idref="f0003">Fig. 2a</figref>.</li><li><figref idref="f0004">Fig. 3b</figref> is the stent structure of <figref idref="f0004">Fig. 3a</figref> shown in an expanded state.</li><li><figref idref="f0005">Fig, 4a</figref> shows a schematic representation of a serpentine band prior to expansion.</li><li><figref idref="f0005">Fig. 4b</figref> shows a schematic representation of the serpentine band of <figref idref="f0005">Fig. 4a</figref> following expansion,</li><li><figref idref="f0006">Fig. 5a</figref> shows a stent not according to the present invention having shaped recesses in the flat.</li><li><figref idref="f0006">Fig. 5b</figref> shows a stent not according to the present invention having alternative shaped recesses in the fiat.</li><li><figref idref="f0007 f0008 f0009">Fig. 6a-6c</figref> show stents having cut-outs in the flat.</li><li><figref idref="f0008">Fig. 6b</figref> shows a stent according to the present invention.</li><li><figref idref="f0007 f0008 f0009">Fig. 7a-7c</figref> are enlargements of the circled region 4 of the stents shown in <figref idref="f0007 f0008 f0009">Figs. 6a-6c</figref>.</li><li><figref idref="f0010 f0011 f0012 f0013">Figs. 8a-10a</figref> show a portion of a serpentine portion of a stent in an unexpanded state, an expanded state and a crimped state, respectively.</li><li><figref idref="f0011 f0012 f0013">Fig. 8b-10b</figref> represent the same stent configuration as that in <figref idref="f0006 f0007">figs. 5a-7a</figref> but with shaped recesses.</li><li><figref idref="f0012 f0013 f0014">Fig. 8c-10c</figref> represent the same stent configuration as that in <figref idref="f0006 f0007">figs. 5a-7a</figref> but with alternative shaped recesses.</li><li><figref idref="f0014 f0015">Figs. 10d-10f</figref> illustrate the same stent configurations as in <figref idref="f0010 f0011 f0012 f0013 f0014">figs. 8a-10c</figref>, above, but with shaped recesses of varying patterns, sizes and geometries.</li><li><figref idref="f0016 f0017">Figs, 11a-11c</figref> and <figref idref="f0021">12</figref> show other stents not according to the present invention in the flat.</li><li><figref idref="f0017 f0018">Figs, 11d-11f</figref> show alternative configurations of the stents shown in <figref idref="f0016 f0017">figs. 11a-11c</figref>.</li><li><figref idref="f0019 f0020">Figs. 11g-11i</figref> show yet other configurations of the stents of <figref idref="f0010 f0011 f0012">figs. 8a-8f</figref>.</li><li><figref idref="f0021 f0022 f0023">Figs. 13-23</figref> show other configurations of cut-out regions and/or optionally shaped recesses.</li><li><figref idref="f0024 f0025">Figs. 24-26</figref> show other stents not according to the present invention in the flat.</li><li><figref idref="f0025">Fig. 27</figref> shows a combination of a catheter and a stent with cut-out regions and/or optionally shaped recesses.</li></ul>

DETAILED DESCRIPTION OF THE INVENTION

0027While this invention may be embodied in many different forms, there are described in detail herein specific preferred embodiments of the invention. This description is an exemplification of the principles of the invention and is not intended to limit the invention to the particular embodiments illustrated.

0028For the purposes of this disclosure, like reference numerals in the figures shall refer to like features unless otherwise indicated. Also for the purposes of this disclosure, the term"cut-out region"shall refer to a region of a serpentine portion of a stent having an opening therethrough, the opening surrounded by stent material. The term does not imply any particular method of forming a stent with cut-outs but, rather, refers to the absence of stent material in the region of the cut-out.

0029Further, for purposes of this disclosure, the term"shaped recess"shall refer to a region of a serpentine portion of a stent does not have an opening therethrough, but rather is a recess in the stent material of varying depth. The term shaped recess shall be used hereinafter to encompass those regions of the serpentine portion of a stent which are reservoirs which may be employed to hold substances such as therapeutic agents and which term may also be used to encompass those which could be described as grooves, channels, slits, flutes, trenches, holes, and so on and so forth.

0030The shaped recess may be of any geometry. Some particular geometries include elongated ellipsoids, substantially circular recesses, oval, rectangular, square, triangular, and so on and so forth. Hereinafter, the term"substantially circular"shall be used to include oval and so forth.

0031These shaped recesses are regions of the serpentine portion of a stent which are of varying depths and which do not extend all the way therethrough. The term"stent material"as used above does not refer to any therapeutic agent which might be provided in the cut-out or shaped recess of the present invention,

0032In general, this invention provides a radially expandable stent formed of any appropriate stent material including the shape memory alloys such as the nickel-titanium shape memory alloys, for example NITINOLo, or stainless steel, for example.

0033Turning now to the figures, <figref idref="f0001 f0002">Fig. 1</figref> a illustrates an example not according to the present invention. Strut 1 has first side a and second side b and strut 2 has a first side a and a second side b. Additionally, each strut has crests 10 and troughs 20. The crests 10 of first side a of strut 1 align the troughs 20 of second side b of strut 1. The crests of second side b of adjacent strut 2 align with the crests 10 of first side a of strut 1 and the troughs 20 of second side b of adjacent strut 2 align with the troughs 20 of first side a of adjacent strut 2. The amplitude as noted above, may be varied.

0034<figref idref="f0001">Fig. 1b</figref> illustrates the stent of <figref idref="f0001">Fig. 1a</figref> in an expanded state. Additionally, connecting members 12 and 14 are shown between longitudinally adjacent struts.

0035<figref idref="f0002">Fig. 1c</figref> illustrates a different type of strut configuration in which bands 15 and 17, for example, may be replaced with bands 13 and 14 as shown in <figref idref="f0001">Fig. 1b</figref>.

0036Band 16 may also be replaced with the innovative strut pattern.

0037Furthermore, any combination of bands 15,16 and/or 17 may be replaced with the strut pattern as described.

0038<figref idref="f0003">Fig. 2a</figref> illustrates an embodiment of the present invention in which substantially circular shaped recesses 30 are located between the aligned crests 10 and troughs 20 on each strut 1,2. The shaped recesses 30 are suitably employed for containing therapeutic agents according to the present invention.

0039The quantity of the recesses employed on the stent, the size of the recess, and the depth, may all be varied in order to control the amount of a substance that is deposited into the body. The recesses assist in preventing the substance from being disturbed during crimping, and all allow delivery of the substance to a target location without removal of the substance because it is located at a subsurface.

0040The above described embodiment results in a stent structure wherein the recesses are in a staggered pattern from strut to strut. This particular embodiment is desirable because it allows the maximization of the surface area available for drug delivery, but without sacrificing the integrity of the stent itself.

0041Substances which may be delivered in this fashion may include any drugs or substances which are desirably delivered into the body of a patient, particularly those which it may be desirable to deliver at a target location in the body. Examples of such substances include, but are not limited to, therapeutic agents including drugs and radioactive The term"therapeutic agcnts"as used herein includes, but is not limited to, antithrombins; antiproliferatives; anesthetics; antifibrins, anticoagulants ; antineoplastic/antiproliferative/antimiotic agents; vascular cell growth promoters (i. e. proteins, cells or vectors including angiogenic growth factors) including growth factor promoters, transcriptional activators and translational promoters ; vascular cell growth inhibitors including growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors, translational repressors, replication inhibitors, inhibitory antibodies, antibodies directed against growth factors, bifunctional molecules consisting of growth factor and cytotoxin, and bifunctional molecules consisting of an antibody and a cytotoxin; chlolesterol lowering agents; vasodilators: genetic material for gene therapy; platelet receptor antagonists; antiplatelet agents such as antiplatelet receptor antibodies; prostaglandin inhibitors; platelet inhibitors; tick antiplatelet peptides, antibodies; agents which interfere with endogenous vasoactive mechanisms; and so on and so forth,

0042Examples of antithrombins, anticoagulants, antiplatelets and antifibrins include, but are not limited to, thrombin inhibitors such as ANGIOMAXfrom Biogen, Inc. in Cambridge, MA; D-phe-pro-arg-chloromethylketone (synthetic antithrombin); dextran; prostacyclin and prostacyclin analogues; sodium heparin; heparin and heparin derivatives; heparinoids; hirudin and recombinant hirudin; glycoprotein lib/Ufa platelet membrane receptor antagonist antibody; prostacyclin and prostacyclin analogues ; argatroban; forskolin ; vapiprost; dipyridamole; urokinase, and PPack (dextrophenylalanine proline arginine cloromethylketone) ; ROC peptide-containing compound; platelet receptor antagonists; antithrombin antibodies; antiplatelet receptors; antibodies; aspirin; prostaglandin inhibitors; platelet inhibitors: tick antiplatelet peptides; and so forth.

0043Examples of cytostatic or antiproliferative agents include, but are not limited to, enoxaprin, angiopeptin, angiotensin converting enzyme inhibitors such as captopril including CAPOTENT and CAPOZIDEi available from Bristol-Myers Squibb Co., cilazapril or lisinopril such as PRINIVILO and PRINIZIDE"available from Merck &amp; Col. Inc, in Whitehouse Station, NJ; calcium channel blockers such as nifedipine; colchicine; monoclonal antibodies capable of block smooth muscle cell proliferation, hirudin and recombinant hirudin, acetylsalicylic acid; fibroblast growth factor (FGF) antagonists; fish oil (omega 3-fatty acid); histamine antagonists; lovastatin (an inhibitor of antifibrin and an inhibitor of HMG-CoA reductase which is a cholesterol lowering drug available under the tradename of ME7IACOR2'from Merok &amp; Co. Inc.); the antithrombins including sodium heparin, heparin and heparin derivatives, heparinoids, hirudin and recombinant hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogues, dextran, dipyrimadole, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), glcyoprotein IIb/IITa platelet membrane receptor antagonist antibody, and so forth, thrombin inhibitors such as ANGIOMANs from Biogen, Inc.; prostaglandin inhibitor; serotonin blockers, steroids; thioprotease inhibitors; PDGF antagonists ; nitric oxide; monoclonal antibodies such as those specific for Platelet- Derived Growth Factor (PDGF) receptors; nitroprusside; phosphodiesterase inhibitors ; suramin; serotonin blockers, triazolopyrimidine (a PDGF antagonist); and so forth.

0044Examples of anti-inflammatory agents include, but are not limited to, dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalaxine, mesalamine, and so forth.

0045Examples of antineoplastic/antiproliferative/antimiotic agents include, but are not limited to, paclitaxel such as TAXOLO Bristol-Myers Squibb Co. in Stamford, CT; docetaxel such as TAXOTERE from Aventis S. A. in Frankfurt, Germany; methotrexate; azathioprine; vincristine; vinblastine; 5-fluorouracil; doxorubicin hydrochloride such as ADRIAMYCIN# fromPharmacia &amp; Upjohn in Peapack, NJ; mitomycin such as MUTAMYCIN from Bristol-Myers Squibb Co. in Stamford, CT; cisplatin; epothilones; endostatin; angiostatin: thymidine kinase inhibitors; and so forth.

0046Examples of anesthetic agents include, but are not limited to, lidocaine, bupivacaine, ropivacaine, and so forth. An example of an antiallergenic agent is permirolast potassium. Another example of a therapeutic agent includes, but is not limited to, alpha-interferon,

0047Examples of genetic materials which may be deposited into a patient's body employing the stents of the present invention include, but are not limited to, antisense DNA and RNA, and DNA coding for tRNA and rRNA, cell cycle inhibitors including CD inhibitors, thymidine kinase (TK) and other agents useful for interfering with cell proliferation, bone morphogenic proteins (BMPs), and so forth.

0048Specific BMPs include, but are not limited to BMP-2, BMP.3, BMP-4, BMP-5, BMP-6 (Vgr-1), BMP-7 (OP-1), BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, BMP-16, and so forth. Preferred for use are BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 and BMP-7. These dimeric proteins may be provided as homodimers, heterodimers, or combinations thereof, and alone or in combination with other molecules such as those molecules capable of inducing an upstream or downstream effect on a BMP. For example, "hedgehog"proteins or the DNA's which encode them may be employed in combination with the BMPs.

0049Cells which may be deposited at a target site in a body may be of human origin (autologous or allogeneic) or may be from an animal source (xenogeneic), or they may be genetically engineered if so desired to deliver proteins of interest at the transplant site such as epithelial cells. The delivery media may be formulated as needed to maintain cell function and viability as is known to those of skill in the art.

0050Radioactive isotopes may also be used for prosthesis usage in radiotllerapeutic procedures and include, but are not limited to, phosphoric acid (B3P3204), palladium (Pd103), cesium (Cs131), iodine (I125) and so forth.

0051The above lists are not exclusive and are intended for exemplary purposes only. The preventative and treatment properties of therapeutic substances or other agents are well known to those of ordinary skill in the art and as such, the above lists are simply provided by way of example, and are not intended to limit the scope of the present invention. Other therapeutic substances or other agents which are not listed herein are equally applicable for use and are also known to those of skill in the art.

0052Example 2b shows the same stent configuration having the substantially circular shaped recesses 30 located between aligned crests 10 and troughs 20 on each strut 1, 2 in an expanded state.

0053<figref idref="f0004">Fig. 3</figref> a illustrates an alternative embodiment of the stent configuration described in <figref idref="f0003">Fig. 2a</figref> in which the shaped recesses 30 are elongated ellipsoids. <figref idref="f0004">Fig. 3b</figref> illustrates the same stent configuration in an expanded state.

0054In another embodiment of the present invention, the stent may comprise a plurality of serpentine portions which extend about the circumference of the stent. For purposes of this disclosure, the term serpentine encompasses, but is not limited to, zig- zag. Thus, a serpentine pattern encompasses, but is not limited to a pattern having sharp turns and a pattern having gradual turns.

0055With reference to the figures, a stent comprising a plurality of serpentine portions which extend about the circumference of the stent is shown generally at 100 in <figref idref="f0008">Fig. 6b</figref>. Serpentine portions 104 include a plurality of turns 105 at the proximal and distal ends of the serpentine portions.

0056Serpentine portions 104 are connected one to the other via one or more connectors 112. As shown in <figref idref="f0008">Fig. 6b</figref>, connectors 112 include curved sections and struts.

0057As used herein, the term"strut"shall be used to encompass both those struts which are straight in configuration, as well as those having any other configuration including those which are curvilinear. First end 112a and second end 112b of connectors 112 are circumferentially offset from one another.

0058As shown in <figref idref="f0007 f0008 f0009 f0010">Figs. 6a-8a</figref>, not according to the present invention, proximal end 106 of serpentine portions 104 and distal end 108 of serpentine portions 104 may be provided with cut-out regions 116.

0059Typically, as shown in the figures, each turn at each end of each serpentine portion will be provided with a cut-out region. Cut-out regions 116 have substantially the same curvature as the turns 105 of the bands themselves and define an inner tam 107 and an outer turn 109. Desirably, cut-out region 116 extends substantially along a radius of turn 105.

0060As shown in <figref idref="f0010">Fig. 8a</figref>, the total longitudinal length of serpentine portion 104 is denoted by L and the longitudinal separation between the inner radii of the serpentine portion is denoted by L1. The width of the cut-out portion, as defined by the maximum separation between inner turn 107 and outer turn 109, is denoted by L2,

0061Upon expansion of the stent, as shown in <figref idref="f0010">Fig. 9a</figref>, the total longitudinal length of the expanded serpentine portion 104, denoted by L'is only slightly shorter than L. The decrease in longitudinal separation between the inner radii of the expanded serpentine portion, denoted by L'i, is at least partially offset by the increase in the maximum separation between inner turn 107 and outer turn 109, denoted by L'2.

0062It may further be desirable to employ the stents for delivering substances into the body of a patient, particularly those wherein it is desirable to deliver at a target location within the body. <figref idref="f0006">Fig, 5a</figref> illustrates generally at 100 a typical stent geometry, and 5b illustrate generally at 100, a stem having connectors 112 and serpentine portions 104 the framework of the stent.

0063Serpentine portion 104w exhibits variable depth recesses 30 of a substantially circular shape which provide a reservoir lor holding a substance such as a therapeutic agent.

0064<figref idref="f0006">Fig. 5b</figref> represents the same stent as shown in <figref idref="f0006">Fig. 5a</figref> but the shaped recesses are represented by an elongated ellipsoid rather than a substantially circular shape. A sideview of examples of a variable depth recess are shown at 103 in <figref idref="f0006">Figs. 5a and 5b</figref>. As described above, the quantity of the recesses employed on the stent, the size of the recess, and the depth, may all be varied in order to control the amount of a substance that is deposited into the body. The recesses assist in preventing the substance from being disturbed during crimping, and all allow delivery of the substance to a target location without removal of the substance because it is located at subsurface.

0065<figref idref="f0008 f0009 f0010 f0011">Figs. 6b to 9b</figref> and <figref idref="f0009 f0007 f0008 f0010 f0011 f0012">6c to 9c</figref> illustrate alternative examples of a stent but having a geometry similar to the stems of <figref idref="f0007 f0008 f0009 f0010">Figs. 6a-9a</figref>. In these embodiments, the cut-out regions of <figref idref="f0007 f0008 f0009 f0010">Figs. 6a-9a</figref>, have been replaced with shaped recesses instead for delivery of a substance such as a therapeutic agent to a target location in the body of a patient. It is desirable that the shaped recesses therefore do not extend all the way through the serpentine portion 104 of stent 100.

0066<figref idref="f0008 f0009 f0010 f0011">Figs. 6b to 9b</figref> represent stents according to the present invention.

0067<figref idref="f0009">Figs. 6c, 7c</figref>, <figref idref="f0012">8c and 9c</figref> represent stents not according to the present invention which have a plurality of shaped recesses on both the turns 104a and the struts 104b of the serpentine portion 104.

0068<figref idref="f0001 f0002">Fig. 1</figref> Of is illustrate of a stent not according to the present invention having a plurality of shaped recesses on both the turns 104a and the struts 104b of the serpentine portion 104. In this particular example, the pattern of placement of the shaped recesses is irregular.

0069Further to the present invention, shaped recesses such as elongated ellipsoids and/or substantially circular recesses, or recesses of some other geometry may be provided on regions of the serpentine of the stent other than those shown in Figs,

00706a-9a. For example, in <figref idref="f0008 f0009 f0010 f0011">Figs. 6b-9b</figref>, the elongated ellipsoids are found on the struts 104b of serpentine portion 104, while in <figref idref="f0009 f0010 f0011 f0012">Figs. 6c-9c</figref>, the substantially circular recesses are found on both the curved sections 104a and the struts 104b of serpentine portion 104.

0071<figref idref="f0013">Fig. 10a</figref> shows the stent having cut-out areas in the turns. <figref idref="f0013">Fig. 10b</figref> illustrates elongated ellipsoid shaped recesses on the stent strut employed in combination with the cut-out regions in the turns. <figref idref="f0014">Fig. 10c</figref> illustrates the stent structure having cut-out regions in the turns and substantially circular shaped recesses on the stent struts. <figref idref="f0014">Fig. 10d</figref> illustrates shaped recesses of various geometries which may be employed. <figref idref="f0015">Fig. 10e</figref> illustrates that the pattern may include both elongated ellipsoids and substantially circular recesses on the same stent, as well as shaped recesses of different sizes. <figref idref="f0015">Fig. 10f</figref> illustrates that the shaped recesses may be placed along the stent strut in an irregular pattern.

0072In the case of a balloon expandable stent where cut-outs are employed as shown in <figref idref="f0013 f0014">Figs. 10a-10c</figref>, during of the stent, the size of cut-out region 116 decreases slightly and the spacing between inner turn 107 and outer turn 109 narrows.

0073The decrease size of the cut-out region of the crimped stent compensates for the increase in length of the stent that may occur during crimping of the stent.

0074It is important to note that other serpentine patterns may be employed as well. For example, the serpentine portions have a constant cross-section along its length or may have a varying cross section along its In the latter case, the width and/or thickness of the serpentine portion maybe varied along the length of the serpentine portion.

0075As shown in <figref idref="f0007 f0008 f0009">Fig, 6</figref>, for example, adjacent serpentine portions 104 are out of phase with one another. It is also within the scope of the invention for adjacent serpentine portions to be in phase with one another. More generally, adjacent serpentine portions may be provided in any phase relationship including 90 degrees and 180 degrees out of phase with one another.

0076Adjacent serpentine portions may be of the same frequency and/or amplitude or may be of different frequencies and/or amplitudes. An example of a stem in which adjacent serpentine portions are of a different frequency and amplitude is shown generally at 100 in <figref idref="f0016">Fig. 11a</figref>. Serpentine portions 104v, 104x and 104z are of a first frequency and amplitude and serpentine portions 104w and 104y are of a second, higher frequency and smaller amplitude.

0077The stent of <figref idref="f0016">Fig. 11b</figref> includes cut-out regions 116 on serpentine 104v, 104x and 104z of the first frequency and amplitude and serpentine portions 104w and 104y of the second, higher frequency and smaller amplitude. Alternatively, the cut-out regions 116 may instead be elongated ellipsoids which do not extend all the way through the stent material.

0078Other shaped connectors may also be provided including substantially straight connectors, as shown in <figref idref="f0016">Fig. 11a</figref>, connectors which are curved and do not have any struts and connectors having one or more curved sections and one or more struts.

0079Also, the first and second ends of each connector may be circumferentially aligned with one another, as shown in <figref idref="f0017">Fig. 11c</figref>, or circumferentially offset from one another as shown in <figref idref="f0007 f0008 f0009">Fig. 6</figref>. An example of a linear connector whose first and seconds ends are circumferentially offset from one another and which is non-parallel to the longitudinal axis of the stent is shown in <patcit id="pcit0004" dnum="WO9626689A"><text>WO 9626689</text></patcit>.

0080Each connector may have a constant cross-section along its length or may have a varying cross section along its length. In the latter case, the width and/or thickness of the connector may be varied along the length of the connector.

0081<figref idref="f0017 f0018 f0019 f0020">Figs. 11d-11i</figref> illustrate the stents of the type shown in figs.

008211a-11c but the cut-out regions have been replaced with various shaped recesses which act as reservoirs for holding substances such as therapeutic agents. <figref idref="f0017">Fig.11d</figref> illustrates a stent wherein elongated ellipsoid recesses are located along the struts 104b of the serpentine portions. The elongated ellipsoid recesses are shown on serpentine portions 104v and 104z. However, other shaped recesses maybe located on any of the serpentines portions and in various combinations as will be illustrated by the following figures..

0083<figref idref="f0018">Fig. 11e</figref> shows an alternative configuration in which the recesses are shown in a more circular shape and are located on both the curved sections 104a and the struts 104b of the serpentine portions. In this embodiment, the recesses are shown on serpentine 104x, but again may be located on any of the serpentine portions.

0084Shown in <figref idref="f0018">fig. 11f</figref> is yet another alternative configuration in which the shaped recesses include both elongated ellipsoids and substantially circular shaped recesses along the serpentine portions 104v-104z. The elongated ellipsoids and substantially circular shaped recesses are shown on both the curved sections 104a and the struts 104b of the serpentine portions. <ul id="ul0002" list-style="none"><li><figref idref="f0019">Fig. 11g</figref> shows an alternative configuration in which, elongated ellipsoid shaped recesses are located along the struts 104b of serpentine portions 104v, 104x and 104z.</li><li><figref idref="f0019">Fig. 11h</figref> illustrates an alternative configuration in which the shaped recesses are triangular in shape and are located on the curved portions 104a of serpentine portions 104w and 104y.</li><li><figref idref="f0020">Fig. 11i</figref> illustrates another alternative configuration in which the shaped recesses are located along both the curved sections 104a and the struts 104b of serpentine portions 104v, 104x and 104z. The shaped recesses maybe of various geometrical shapes and patterns, and the placement of the shaped recesses may vary as well. Further, size and depth may be varied as well.</li></ul>

0085The above figures are intended to be illustrative of only some of the shapes of the recessed areas and the patterns of placement on the stent.

0086The stents may also be provided in configurations in configurations in which there is a one-to-one relationship between the number of turns in a serpentine portion and the number of connectors, as shown in <figref idref="f0007">Fig. 6a</figref>, in configurations in which there are fewer connectors than turns and in configurations in which there are more connectors than turns.

0087An example of the former is shown in <figref idref="f0021">Fig. 12</figref>. Every other pair of turns is connected in the stent of <figref idref="f0021">Fig. 12</figref>. The stents may also be provided with other regular and irregular spacings of the connectors,

0088Stents having cut-out regions or shaped recesses of varying configurations or geometries in the regions of the turns are also described, as are shaped recesses of various configurations and geometries located in the regions of the struts of the serpentine portions.

0089Another example of a cut-out region in a turn of a serpentine portion of a stent is shown in <figref idref="f0021">Fig. 13</figref>. Cut-out region 116 in turn 105 is centered so that inner turn 107 is of the same width as outer turn 109. regions 116 may also be located closer to the inner diameter of turn 105 as shown in <figref idref="f0021">Fig. 14</figref>, resulting in inner turn 107 having a narrower width than outer turn 109. In another embodiment, cut-out region 116 is located closer to the outer diameter of turn 105 as shown in <figref idref="f0021">Fig. 15</figref>, resulting in inner turn 107 having a wider width than outer turn 109.

0090The size of cut-out region 116 may be altered to control the extent of foreshortening of the stent as well as to control the force needed to expand the stent in the case of a baboon expandable stent. An example of a wide cut-out region is shown in <figref idref="f0022">Fig. 16</figref>.

0091More than one cut-out region may be provided in the vicinity of a turn. <figref idref="f0022">Fig. 17a</figref> shows an example in which three circular cut-out regions 116 are provided in turn 105. Another example in which multiple cut-outs are provided is shown in <figref idref="f0022">Fig. 17d</figref>.

0092More generally, any of the stents described herein may comprise multiple cut-outs in the vicinity of the turns.

0093In many of the examples described herein, the cut- out regions have a substantially arcuate appearance. Other shaped cut-outs may also be provided. By way of example only, an elliptical cut-out region having a major axis parallel to the longitudinal axis of the stent is shown at 116 in <figref idref="f0022">Fig. 17b</figref>. An elliptical cut-out, region having a minor axis parallel to the longitudinal axis of the stent is shown at 116 in <figref idref="f0022">Fig. 17c</figref>. The presence of multiple elliptical cut-out regions in shown in <figref idref="f0022">Fig. 17d</figref>.

0094The length of the cut-out region may also be adjusted. For the cut-out regions in the turns of the serpentine portion, for example, a minimum length cut-out region 116 may be found, for example, in <figref idref="f0022">Fig. 17a</figref> while a maximum length cut-out region 116 maybe found in <figref idref="f0023">Fig, 18</figref>, for example. Cut-out region 116 shown in <figref idref="f0023">Fig. 18</figref> extends along the entire length of the radiuses portion of turn 105. It is noted that turn 105 includes a plurality of cut-out regions 116. Any of the other examples may be modified to provide a plurality of cut-out regions per turn. For example, in those examples in which the cut- out regions are arcuate, multiple arcuate regions may be provided.

0095The cut-out region may have an irregular shape as shown in <figref idref="f0023">Fig. 19</figref>.

0096Where a connector extends from the turn, as shown in <figref idref="f0023">Fig. 20</figref>, cut-out region 116 may optionally be limited to the region of turn 105 corresponding to the longitudinal extension of connector 112. Connector 112 of <figref idref="f0023">Fig. 20</figref> extends from the inner turn 107 or inner diameter of turn 105. An example of a larger cut-out region 116 which extends toward a connector 112 extending from inner turn 107 is shown in <figref idref="f0023">Fig. 21</figref>.

0097<figref idref="f0023">Fig. 22</figref> illustrates a larger cut-out region 116 which extends into connector 112. Connector 112 extends from inner turn 107. <figref idref="f0023">Fig. 23</figref> illustrates a larger cut-out region 116 which extends into connector 112 which, in turn, extends from outer turn 109.

0098The cut-out regions as illustrated in <figref idref="f0021 f0022 f0023">figs. 13-23</figref> may be replaced with recesses in the form of elongated ellipsoids or other shaped recesses that extend only partially through the stent at various depths rather than as cut- outs which extend all the way through the stent. Furthermore, the stent may have some combination of cut-out regions and recesses.

0099Cut-out regions or shaped recesses may be provided in all of tile turns of the serpentine portions of the stent, as shown in <figref idref="f0007 f0008 f0009">Fig. 6</figref>, or in only some of the turns of the serpentine portions. An example of a stent having serpentine portion with cut-out regions or shaped recesses in less all of the turns is shown in <figref idref="f0024">Fig. 24</figref>.

0100In the stent of <figref idref="f0024">Fig. 24</figref>, the cut-out regions are disposed to facilitate opening of the proximal and distal ends of the stent first, the elongated ellipsoid recesses are disposed to act as a reservoir for holding a substance such as a drug which is to be delivered to a target location in the body. The serpentine portions in the proximal end of the stent have cut-out regions or shaped recesses 30 in the proximal turns of the serpentines and the serpentine portions in the distal end of the stent have cut-out regions or shaped recesses 30 in the distal turns of the serpentines. Another example in which the serpentine portions in the proximal end of the stent have cut-out regions 116 or shaped recesses 30 in the distal turns of the serpentines and the serpentine portions in the distal end of the stent have cut-out regions 116 or shaped recesses 30 in the proximal turns of the serpentines is shown in <figref idref="f0024">Fig. 25</figref>. If the stent as shown in <figref idref="f0024">Fig. 25</figref> has cut-outs 116 rather than shaped recesses 30, it will open in the center prior to opening in the ends. More generally, individual serpentine portions of the stent may be provided with cut-out regions exclusively in the distal end of the serpentine or the proximal end of the serpentine to tailor the properties of the stent depending on the opening properties desired, and whether or not the stent is also being employed for drug delivery.

0101Adjacent cut-outs or shaped recesses may be spaced further apart along the serpentine portion. For example cut-out regions 116 or shaped recesses 30 may be provided at every third or fourth turn or may be spaced further apart.

0102Adjacent pairs of cut-outs 116 or shaped recesses 30 may be spaced further apart along the serpentine portion. For example, as shown in <figref idref="f0025">Fig. 26</figref>, every other pair of turns 105 are provided with cut-out regions 116 or shaped recesses 30. Adjacent pairs of cut-out regions or shaped recesses may also be spaced further apart from one another along the serpentine portion 104 of stent 100, Other spacings of cut-out regions or shaped recesses are also possible.

0103It is within the scope of the present invention, to replace any shaped recess with a shaped recess of a different shape. Varying the quantity, size. i. e. length and width, as well as the depth of the shaped recess may be employed to control the amount of a substance which win be deposited upon deployment of the stent.

0104More generally, cut-out regions, elongated ellipsoids or other shaped recesses may be provided exclusively in some or all of the turns of the proximal and/or distal serpentine portions of the stent. The number of cut-out regions or shaped recesses in the stents may be varied along the length of the stent both in the on the struts and curved sections of the stent, and in turns of the serpentines may also be varied along the length of the stent, hi the case of a low opening pressure stent, the number of cut-out regions in the serpentine portions may decrease from the proximal and/or distal ends of the stent to the middle of the stent. Less pressure is required to expand those portions of the stent having more cut-out This feature may provide where a retaining sleeve is disposed about the proximal and/or distal ends of the stent.

0105Here are also described stents having end serpentine portion (s) at the proximal and/or distal ends of the stent and intermediate serpentine portions between the end serpentine, where one or both of the end serpentine portions have more cut-out regions, elongated ellipsoids or other shaped recesses than the intermediate serpentine portions. Such as stent is shown by way of example in <figref idref="f0016 f0017 f0018 f0019 f0020">Fig. 11</figref> a or 11d. In the stent of <figref idref="f0016">Fig, 11a</figref>, the intermediate serpentine portions do not have any cut-out regions, elongated ellipsoids or other shaped recesses. Desirably, one or both of the end portions require less pressure to expand than the intermediate portions.

0106Here are also described stents having end serpentine portion (s) at the proximal and/or distal ends of the stent and intermediate serpentine portions between the end serpentine, where one or both of the end serpentine portions have larger cut-out regions, elongated ellipsoids or other shaped recesses than the intermediate serpentine portions. Desirably, in the case of cut-out regions, one or both of the end portions require less pressure to expand than the intermediate portions.

0107Here are also described examples in which the cut-out regions are designed and distributed such that the middle portion of the stent opens prior to one or both of the proximal and distal ends of the stent. For example, the middle portion of the stent may have more cut-out regions than one or both ends of the stent or may be provided with larger cut-out regions than one or both ends of the stent. An example of such a stent is shown in <figref idref="f0001 f0002">Fig. 1</figref><figref idref="f0001">1b</figref>. The stent of <figref idref="f0001 f0002">Fig, 1</figref><figref idref="f0001">1b</figref> has cut-outs only in the middle serpentine.

0108The cut-outs regions as described in the paragraph above, may be replaced with shaped recesses rather than etit-out regions for drug delivery, an example of which is shown in Fig. live. Of course, the substantially circular shaped recesses may be replaced with other geometric shapes including elongated ellipsoids, for example, as well.

0109The number of cut-out regions may also be adjusted to allow for increased stent securement in desired areas of the stent. Specifically, in the case of a balloon expandable stent, those regions of a stent lacking cut-out regions will typically have increased securement to a balloon catheter when crimped on a balloon and catheter than regions having cut-outs.

0110The cut-out regions that are provided in the turns of the inventive stents allow the turns of the stent to open more easily when a given force is applied thereto, thus facilitating expansion of the stent. This in turn, allows for wider struts to be employed, thereby increasing the radiopacity of the stent.

0111It is also here described a radially expandable stent comprising a plurality of serpentine portions extending about the circumference of the stent, each serpentine portion having a plurality of turns where at least some of the turns and/or struts of the serpentine portions have at least some shaped recesses or wherein at least some of the turns have at least some fully enclosed cut-out regions and shaped recesses extending therethrough, or at least some of the turns have fully enclosed cut-out regions extending therethrough and some of the struts have at least some shaped recesses.

0112The shaped recesses are distributed about the stent so as to achieve optimum delivery of a drug upon deployment of the stent.

0113The cut-out regions may be distributed about the stent so that the stent opens in a non-uniform manner. Desirably, the stent includes a proximal serpentine portion at a proximal end of the stent, a distal serpentine portion at a distal end of the stent i and a middle portion disposed between the proximal and distal ends of the stent and the cut-out regions are distributed such that the proximal and distal ends of the stent open prior to the middle portion of the stent. The cut-out regions may also be distributed such that the middle portion of the stent opens prior to one or both ends of the also desirably, the cut-out regions are substantially arcuate prior to expansion of the stent.

0114It is also here described a stent such as that shown in <figref idref="f0005">Fig. 4</figref> and many of the other figures disclosed herein comprising at least one tubular serpentine member 104 having a first end and a second end. The serpentine member has a plurality of turns 105 at the first end and a plurality of turns at the second end. Each of the turns at the first and second ends have a fully enclosed cut-out region extending therethrough, or elongated ellipsoid or other shaped recess 30. Typically, the stent will comprise a plurality of tubular serpentine members with adjacent tubular serpentine members connected one to the other. Desirably, the shape of the fuLly enclosed cut-out regions, elongated ellipsoid or other shaped recess changes as the stent is expanded. More desirably, the fully enclosed cui-oiii regions, elongated ellipsoids, or some such other shaped recess is characterized by a first area when the stent is in an unexpanded configuration and by a second area when the stent is in an expanded configuration, the second area larger than the first area. The stents may also be provided in configurations in which the fully enclosed cut-out regions, or shaped recesses are characterized by a first width when the stent is in an unexpanded configuration and by a second width when the stent is in an expanded configuration, the second width greater than the width. Typically, the cut-out regions, or other shaped recesses of the inventive stents will be arcuate when the stent is in the unexpanded state although curt- out regions or shaped recesses of other shapes as described above are also possible.

0115The stents described herein may be made of any suitable stent material including metals and polymeric materials as are known in the art. Suitable metals include stainless steels, tantalum, titanium, nitinol, Elgiloy and MP35N.

0116Portions or the entirety of the stents may be radiopaque. For example, a gold coating may be provided to selected regions or the entirety of the inventive stents.

0117The stents may be laser cut, chemically etched, electrodischarge machined or cut using any other suitable technique from a tube. The stent pattern may also be cut into a sheet using any of the above-mentioned techniques or any other suitable technique, the sheet rolled into tubular and the ends welded or otherwise joined together, The stent designs may also be used in coiled sheet stents where the sheet which forms the stent is formed into a roll which may unroll to a wider opening.

0118The stents may be provided with biocompatible coatings such as lubricious coating or other types of coatings known to those of skill in the art.

0119The entirety of the stem may be coated with the therapeutic agent, the cut-out regions only be provided with the therapeutic agent, or the shaped recesses may be provided with the therapeutic agent, or some combination thereof In one embodiment, one or more of the shaped recesses and/or cut-out regions will be filled with a therapeutic agent. It is also possible for only shaped recesses to be filled with a therapeutic agent. Moreover, it may be desirable to have shaped recesses and/or cut-out regions including a therapeutic agent in one portion of the stent and cut-out regions without a therapeutic agent in another portion of the stent. For example, the shaped recesses and/or cut-out regions at one or both ends of the stent may include a therapeutic agent, and the cut-out regions in the middle of the stent may lack a therapeutic agent. As another example, the shaped recesses and/or cut-out regions in the middle of the stent may include a therapeutic agent and the cut-out regions in the ends of the stent may lack the agent.

0120The shaped recesses and/or cut-out regions may be selectively filled by masking other portions of the stent and spraying, dipping or otherwise disposing therapeutic agent only in the shaped recesses or cut-out regions. For example, the stent may be placed on a mandril and masked so that the therapeutic agent may be disposed only in desired shaped recesses and/or cut-out regions of the stent.

0121It may be desirable to provide only shaped recesses on the stent which are to be selectively filled with a therapeutic agent. The stem may optionally include etit-out regions to facilitate opening of the stent, but which do not have any therapeutic agent therein.

0122The stents described herein may be used in any suitable bodily vessel including the coronary arteries, the peripheral arteries, arteries of the neck, cerebral arteries, veins, biliary ducts, urethras, ureters, fallopian tubes, bronchial tubes, the trachea, the esophagus and the prostate. Its uses include supporting vessels in the region of lesions and vessels in the region of aneurisms. It is also particularly suited for use as an intracranial stent.

0123It is also here described combination of a stent and a delivery catheter where a retaining sleeve is disposed about the proximal and/or distal end of the stent, as shown by way of example in <figref idref="f0025">Fig. 27</figref>.

0124Catheter 200 includes stent 100 disposed about, balloon 208 and catheter member 202.

0125Retaining sleeves 204 are provided at the proximal and/or distal ends of the stent.

0126Stent 100 desirably has few and/or larger cut-out regions at the proximal and/or distal end to accommodate the additional force that is required to expand the stent in the region of the retaining sleeve,

0127The above disclosure is intended to be illustrative and not exhaustive.

0128This description will suggest many variations and alternatives to one of ordinary skill in this art.

0129The scope of the present invention is defined by the appended claims.