EP2199801A3

Biomarkers for early detection of ovarian cancer

Abstract

The present invention relates to a method of screening for ovarian cancer in a subject comprising: (a) measuring at least three biomarkers in a test serum sample of the subject, wherein said at least three biomarkers include transthyretin, apolipoprotein Al (ApoAl) and transferring; and (b) comparing the measured at least three biomarkers of the test serum sample to a measurement of the three biomarkers in a normal serum sample, wherein a decrease in the measured three biomarkers of the test serum sample compared to the measurement of the three biomarkers in the normal serum sample is indicative of ovarian neoplasia.

Term

Term ended

Projected expiry passed 14 July 2025, 1.2 years ago.

Every citation, both ways

Citations
Document	Relation	Office	Category	Cited during	Relevant claims
US2003027216A1	Cites	United States of America	A	Search report	1-22
WO2004012588A2	Cites	World Intellectual Property Organization (WIPO)	A	Search report	1-22
ZHANG ZHEN ET AL: "Protein identification and immunoassay evaluation of a panel of biomarkers discovered through proteomic profiling for the detection of ovarian cancer", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 45, 1 March 2004 (2004-03-01), pages 242, XP002485511, ISSN: 0197-016X	Non-patent	–	–	Search report	–
TOSNER J ET AL: "SERUM PREALBUMIN, TRANSFERIN AND ALPHA-1-ACID GLYCOPROTEIN IN PATIENTS WITH GYNECOLOGICAL CARCINOMAS", NEOPLASMA, SCIENCES, vol. 35, no. 4, 1 January 1988 (1988-01-01), pages 403 - 412, XP008056610, ISSN: 0028-2685	Non-patent	–	–	Search report	–
KOZAK K R ET AL: "CHARACTERIZATION OF SERUM BIOMAKERS FOR DETECTION OF EARLY STAGE OVARIAN CANCER", PROTEOMICS, WILEY - VCH VERLAG, WEINHEIM, DE LNKD- DOI:10.1002/PMIC.200500093, vol. 5, no. 17, 1 November 2005 (2005-11-01), pages 4589 - 4596, XP008056606, ISSN: 1615-9853	Non-patent	–	–	Search report	–

30 members in 6 offices

This recordMember, by publication datePriority claim

Priority claims5

Priority claims
Document	Office	Kind	Date
588007P	United States of America	–	2004-07-14
58800704	United States of America	P	2004-07-14
674489P	United States of America	–	2005-04-25
67448905	United States of America	P	2005-04-25
05771584	European Patent Office (EPO)	A	2005-07-14

Members30

Family members, oldest first
Document	Office	Kind
WO2006019906A1	World Intellectual Property Organization (WIPO)	A1	2006-02-23
EP1789805A1	European Patent Office (EPO)	A1	2007-05-30
US2008038754A1	United States of America	A1	2008-02-14
US7670792B2	United States of America	B2	2010-03-02
US2010081151A1	United States of America	A1	2010-04-01
EP2199801A2	European Patent Office (EPO)	A2	2010-06-23
EP2199801A3This record	European Patent Office (EPO)	A3	2010-08-25
EP1789805B1	European Patent Office (EPO)	B1	2010-09-15
AT481645T	Austria	T	2010-10-15
ATE481645T1	Austria	T1	2010-10-15
DE602005023629D1	Germany	D1	2010-10-28
EP2261672A2	European Patent Office (EPO)	A2	2010-12-15
US2011027894A1	United States of America	A1	2011-02-03
EP2261672A3	European Patent Office (EPO)	A3	2011-10-05
WO2012047930A2	World Intellectual Property Organization (WIPO)	A2	2012-04-12
WO2012047930A3	World Intellectual Property Organization (WIPO)	A3	2012-06-14
US8323915B2	United States of America	B2	2012-12-04
US2013090256A1	United States of America	A1	2013-04-11
EP2199801B1	European Patent Office (EPO)	B1	2013-05-29
DK2199801T3	Denmark	T3	2013-08-05
US2013217636A1	United States of America	A1	2013-08-22
US2014088018A9	United States of America	A9	2014-03-27
EP2261672B1	European Patent Office (EPO)	B1	2014-09-03
EP2848942A1	European Patent Office (EPO)	A1	2015-03-18
US9110083B2	United States of America	B2	2015-08-18
US2016069886A1	United States of America	A1	2016-03-10
US9487575B2	United States of America	B2	2016-11-08
US9488655B2	United States of America	B2	2016-11-08
EP2848942B1	European Patent Office (EPO)	B1	2017-03-08
EP3203241A1	European Patent Office (EPO)	A1	2017-08-09

70 legal events, as 10 offices reported them to INPADOC

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	Event	Code	Office
2019-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2019-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2019-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2019-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2019-03-27	Gb: european patent ceased through non-payment of renewal feeCeasedGBPC	GBPC	EP
2019-02-25	Ep patent lapsedLapsedEBP	EBP	DK
2019-02-01	Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal feeWithdrawnR119	R119	DE
2017-11-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2017-10-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2017-10-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2017-10-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2017-07-26	Fee paymentPLFP	PLFP	FR
2016-07-26	Fee paymentPLFP	PLFP	FR
2015-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2015-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2015-06-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2015-06-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-06-12	No opposition filed against granted patent, or epo opposition proceedings concluded without decisionGrantedR097	R097	DE
2014-05-07	No opposition filedOpposition26N	26N	EP
2014-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-04-23	Patent lapsedLapsedMM4A	MM4A	IE
2014-04-04	No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE	PLBE	EP
2014-04-04	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA	STAA	EP
2014-02-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-02-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-02-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-02-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-02-28	Patent ceasedCeasedPL	PL	CH
2014-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-12-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-11-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-11-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-11-06	Discontinued in the netherlands as no translation has been filedVDEP	VDEP	NL
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-10-25	Invalidated european patentMG4D	MG4D	LT
2013-10-15	Deletion acc. to par. 5 (withdrawal of the translation of the ep patent)MK05	MK05	AT
2013-08-05	Ep patent with danish claimsT3	T3	DK
2013-07-25	Dpma publication of mentioned ep patent grantGrantedR096	R096	DE
2013-07-03	European patents granted designating irelandGrantedFG4D	FG4D	IE
2013-06-15	Reference to at number (ep patent validated in austria)REF	REF	AT
2013-05-31	European patent takes effect as a national patent in ch/liEP	EP	CH
2013-05-29	Divisional application: reference to earlier applicationAC	AC	EP
2013-05-29	Designated contracting statesAK	AK	EP
2013-05-29	European patent grantedGrantedFG4D	FG4D	GB
2013-05-15	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1	EP
2013-04-26	(expected) grantORIGINAL CODE: 0009210GRAA	GRAA	EP
2013-04-12	Grant fee paidORIGINAL CODE: EPIDOSNIGR3GRAS	GRAS	EP
2012-11-23	Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOSNIGR1GRAP	GRAP	EP
2011-07-27	First examination report despatched17Q	17Q	EP
2011-04-13	Request for examination filed17P	17P	EP
2010-08-25	Designated contracting statesAK	AK	EP
2010-08-25	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2010-08-25	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2010-07-23	Search report despatchedORIGINAL CODE: 0009013PUAL	PUAL	EP
2010-06-23	Divisional application: reference to earlier applicationAC	AC	EP
2010-06-23	Designated contracting statesAK	AK	EP
2010-05-21	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI	EP

Biomarkers for early detection of ovarian cancer

Abstract

Term

Priority claims5

Members30

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Designated states1