EP2147679A3
Compositions and methods for modulating blood-brain barrier transport
Abstract
This invention provides conjugates of therapeutic or active agents with melanotransferrin or with other ligands of a melanotransferrin receptor, melanotransferrin receptor modulators, and related compositions and methods for modulating blood-brain barrier transport by providing methods of screening and selecting such conjugates, ligands, and modulators in vitro and in vivo, and methods of use of such conjugates, modulators and ligands in diagnosis and the treatment of diseases, including particularly diseases of the central nervous system or lysosomal storage diseases.
Term
Term ended
Projected expiry passed 25 July 2022, 4.2 years ago.
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Every citation, both ways
| Document | Relation | Office | Category | Cited during | Relevant claims |
|---|---|---|---|---|---|
| WO0004926A2 | Cites | World Intellectual Property Organization (WIPO) | X | Search report | 1-15 |
| WO0071714A2 | Cites | World Intellectual Property Organization (WIPO) | A | Search report | 1-15 |
| US6156311A | Cites | United States of America | A | Search report | 1-15 |
| SCHWARZ HANS PETER ET AL: "Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice", 1 March 2000, BLOOD, VOL. 95, NR. 5, PAGE(S) 1703-1708, ISSN: 0006-4971, XP002564959 | Non-patent | – | – | Search report | – |
23 members in 9 offices
Priority claims7
| Document | Office | Kind | Date |
|---|---|---|---|
| 308002P | United States of America | – | |
| 30800201 | United States of America | P | |
| 02756731 | European Patent Office (EPO) | A | |
| 02756731 | – | – | – |
| 308002P | – | – | – |
| EP20020756731 | – | – | – |
| US20010308002P | – | – | – |
Members23
| Document | Office | Kind | |
|---|---|---|---|
| CA2450073A1 | Canada | A1 | |
| WO03009815A2 | World Intellectual Property Organization (WIPO) | A2 | |
| US2003129186A1 | United States of America | A1 | |
| JP2005509144A | Japan | A | |
| WO03009815A3 | World Intellectual Property Organization (WIPO) | A3 | |
| EP1554572A2 | European Patent Office (EPO) | A2 | |
| EP1554572A4 | European Patent Office (EPO) | A4 | |
| US2007167365A1 | United States of America | A1 | |
| AU2002322720B2 | Australia | B2 | |
| JP4202250B2 | Japan | B2 | |
| EP1554572B1 | European Patent Office (EPO) | B1 | |
| AT445838T | Austria | T | |
| ATE445838T1 | Austria | T1 | |
| DE60234057D1 | Germany | D1 | |
| EP2147679A2 | European Patent Office (EPO) | A2 | |
| EP2147679A3This record | European Patent Office (EPO) | A3 | |
| US7700554B2 | United States of America | B2 | |
| US2010183581A1 | United States of America | A1 | |
| HK1140686A | Hong Kong, China | A | |
| HK1140686A1 | Hong Kong, China | A1 | |
| US7977317B2 | United States of America | B2 | |
| EP2147679B1 | European Patent Office (EPO) | B1 | |
| CA2450073C | Canada | C |
84 legal events, as 9 offices reported them to INPADOC
Over the term
Point at a mark for the eventEvents
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|---|---|---|---|
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Gb: european patent ceased through non-payment of renewal feeCeasedGBPC | GBPC | EP | |
| Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal feeWithdrawnR119 | R119 | DE | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Fee paymentPLFP | PLFP | FR | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Fee paymentPLFP | PLFP | FR | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| No opposition filedOpposition26N | 26N | EP | |
| No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE | PLBE | EP | |
| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA | STAA | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Patent lapsedLapsedMM4A | MM4A | IE | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| No opposition filed against granted patent, or epo opposition proceedings concluded without decisionGrantedR097 | R097 | DE | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Patent ceasedCeasedPL | PL | CH | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Discontinued in the netherlands as no translation has been filedVDEP | VDEP | NL | |
| Deletion acc. to par. 5 (withdrawal of the translation of the ep patent)MK05 | MK05 | AT | |
| Standard patents granted in hong kongGrantedGR | GR | HK | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Dpma publication of mentioned ep patent grantGrantedR096 | R096 | DE | |
| European patents granted designating irelandGrantedFG4D | FG4D | IE | |
| Reference to at number (ep patent enters austrian national phase)REF | REF | AT | |
| European patent takes effect as a national patent in ch/liEP | EP | CH | |
| Divisional application: reference to earlier applicationAC | AC | EP | |
| Designated contracting statesAK | AK | EP | |
| European patent grantedGrantedFG4D | FG4D | GB | |
| (expected) grantORIGINAL CODE: 0009210GRAA | GRAA | EP | |
| Grant fee paidORIGINAL CODE: EPIDOSNIGR3GRAS | GRAS | EP | |
| Intention to grant announcedINTG | INTG | EP | |
| Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOSNIGR1GRAP | GRAP | EP | |
| Information provided on ipc code assigned before grantRIC1 | RIC1 | EP | |
| Information provided on ipc code assigned before grantRIC1 | RIC1 | EP | |
| Information provided on ipc code assigned before grantRIC1 | RIC1 | EP | |
| Information provided on ipc code assigned before grantRIC1 | RIC1 | EP | |
| Amendment of ipc main classPREVIOUS MAIN CLASS: A61K0038000000R079 | R079 | DE | |
| First examination report despatched17Q | 17Q | EP | |
| Requests to designate patent in hong kongDE | DE | HK | |
| Request for examination filed17P | 17P | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Designated contracting statesAK | AK | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Information on inventor provided before grant (corrected)RIN1 | RIN1 | EP | |
| Search report despatchedORIGINAL CODE: 0009013PUAL | PUAL | EP | |
| Divisional application: reference to earlier applicationAC | AC | EP | |
| Designated contracting statesAK | AK | EP | |
| Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI | PUAI | EP |
Numbers
- Publication
- 2147679
- Publication, DOCDB
- 2147679
- Publication, EPODOC
- EP2147679
- Application
- 9012753
- Application, DOCDB
- 09012753
- Application, EPODOC
- EP20090012753
Titles3
- German
- Zusammensetzungen und Verfahren zur Modulierung von Blut-Hirn-Schrankentransporten
- English
- Compositions and methods for modulating blood-brain barrier transport
- French
- Compositions et procédés de modulation de transport de barrière hématoencéphalique
Classification
- CPC, 13
- A61K38/40
- A61K38/177
- A61K2039/505
- C07K16/40
- A61K47/644
- A61P25/00
- A61P25/16
- A61P25/18
- A61P25/28
- A61P35/00
- A61P43/00
- A61P7/02
- A61P9/10
- IPC, 16
- A61K38 00
- A61K45 00
- A61K47 48
- A61P7 02
- A61P9 10
- A61P25 00
- A61P35 00
- A61P43 00
- C07K14 79
- C07K16 40
- C07K19 00
- C12N5 08
- C12Q1 02
- G01N33 15
- G01N33 50
- G01N33 68
Designated states1
- Contracting states, 1
- Türkiye