Nova Patents
EP2017341A3

Apo-2 ligand

Abstract

A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

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Term ended

Projected expiry passed 15 January 2019, 7.7 years ago.

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Citations
DocumentRelationOfficeCategoryCited duringRelevant claims
WO9701633A1CitesWorld Intellectual Property Organization (WIPO)XSearch report1-4,6-21
WO9725428A1CitesWorld Intellectual Property Organization (WIPO)XSearch report1-4,6-21
PITTI R M ET AL: "INDUCTION OF APOPTOSIS BY APO-2 LIGAND, A NEW MEMBER OF THE TUMOR NECROSIS FACTOR CYTOKINE FAMILY", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 22, 31 May 1996 (1996-05-31), pages 12687 - 12690, XP002031265Non-patent––Search report–
WILEY S R ET AL: "IDENTIFICATION AND CHARACTERIZATION OF A NEW MEMBER OF THE TNF FAMILY THAT INDUCES APOPTOSIS", IMMUNITY, vol. 3, no. 6, 1 December 1995 (1995-12-01), pages 673 - 682, XP000672297Non-patent––Search report–
ASHKENAZI A ET AL: "INDUCTION OF APOPTOSIS BY APO-2 LIGAND, A NEW MEMBER OF THE TUMOR NECROSIS FACTOR CYTOKINE FAMILY", EUROPEAN CYTOKINE NETWORK, vol. 7, no. 2, 1 April 1996 (1996-04-01), pages 159, XP000672223Non-patent––Search report–