Cyano anthranilamide insecticides

Description of equivalent WO 2004067528 A1

TITLE CYA O ANT-TRANTXAMLDE TNSECTICIDES

0002FIELD OF THE L NENTION This invention relates to certain anthranilamides, their N-oxides, salts and compositions suitable for agronomic and nonagronomic uses, including those uses listed below, and a method of their use for controlling invertebrate pests in both agronomic and nonagronomic environments.

0003BACKGROUND OF THE LNNENTION The control of invertebrate pests is extremely important in achieving high crop efficiency. Damage by invertebrate pests to growing and stored agronomic crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. The control of invertebrate pests in forestry, greenhouse crops, ornamentals, nursery crops, stored food and fiber products, livestock, household, and public and animal health is also important. Many products are commercially available for these purposes, but the need continues for new compounds that are more effective, less costly, less toxic, environmentally safer or have different modes of action.

0004WO 01/070671 discloses N-acyl anthranilic acid derivatives of Formula i as arthropodicides

0005<img file="EP1599463A1_D0001.tif" />

0006wherein, z^'.zter alia, A and B are independently O or S; J is an optionally substituted phenyl ring, 5- or 6-membered heteroaromatic ring, naphthyl ring system or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system; R¹ and R³ are independently H or optionally substituted C_j-Cg alkyl; R² is H or C- Cg alkyl; each R⁴ is independently H, C-^Cg alkyl, C^-Cg haloalkyl, halogen or CΝ; and n is 1 to 4. SUMMARY OF THE LNNENTION This invention pertains to compounds of Formula 1, their N-oxides or salts thereof

0007<img file="EP1599463A1_D0002.tif" />

0008wherein RHs Me, Cl, Br or F;

0009R² is F, Cl, Br, C1-C4 haloalkyl or C1-C4 haloalkoxy; R³ is F, Cl or Br;

0010R⁴ is H; C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C5 cycloalkyl, or C4-C6 cycloalkylalkyl, each optionally substituted with one substituent selected from the group consisting of halogen, CΝ, SMe, S(O)Me, S(O)₂Me, and OMe;

0011R⁵ is H or Me; R⁶ is H, F or Cl; and R⁷ is H, F or Cl.

0012This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula 1 and at least one additional component selected from the group consisting of a surfactant, a solid diluent and liquid diluent and optionally an effective amount of at least one additional biologically active compound or agent.

0013This invention also pertains to a method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula 1 (e.g., as a composition described herein). This invention also relates to a metho for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a composition comprising a biologically effective amount of a compound of Formula 1 and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent, said composition optionally further comprising an effective amount of a of at least one additional biologically active compound or agent. This invention further pertains to a spray composition comprising a compound of Formula 1 and a propellant, and to a bait composition comprising a compound of Formula 1- one or more food materials, an optional attractant, and an optional humectant. This invention also pertains to a device for controlling an invertebrate pest comprising said bait composition and a housing adapted to receive the bait composition, wherein the housing has at least one opening sized to permit the invertebrate pest to pass through the opening so the invertebrate pest can gain access to the bait composition from a location outside the housing and wherein the housing is further adapted to be placed in or near a locus of potential or known activity for the invertebrate pest. DETAILS OF THE INVENTION

0014In the above recitations, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl" includes straight-chain or branched alkyl, such as, methyl, ethyl, R-propyl, i-propyl, or the different butyl isomers. The term "halogen", either alone or in compound words such as "haloalkoxy", includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl", or "haloalkoxy", said alkyl or alkoxy may be partially or fully substituted with halogen atoms which may be the same or different. Examples of "haloalkyl" include F₃C, C1CH₂, CF₃CH₂ and CF₃CC1₂. Examples of "haloalkoxy" include CF₃O, HCF₂O, CCl₃CH₂O, HCF₂CH₂CH₂O and CF₃CH₂O.

0015One skilled in the art will appreciate that not all nitrogen-containing heterocycles can form N-oxides since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize those nitrogen-containing heterocycles which can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for the preparation of N-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethydioxirane. These methods for the preparation of N-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748-750, S. N. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistiγ, vol. 3, pp 18-20, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grirmnett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R. Katritzky, Ed., Academic Press; M. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistiy, vol. 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.

0016Compounds of this invention can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. Accordingly, the present invention comprises compounds selected from Formula 1, N-oxides and salts thereof. The compounds ofthe invention may be present as a mixture of stereoisomers, individual stereoisomers, or as an optically active form.

0017The salts ofthe compounds ofthe invention include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric,

00184-toluenesulfonic or valeric acids. In the compositions and methods of this invention, the salts ofthe compounds ofthe invention are preferably suitable for the agronomic and/or non- agronomic uses described herein.

0019Of note are compounds of Formula I wherein R⁴ is H or C1-C4 alkyl optionally substituted with one substituent selected from the group consisting of CΝ, SMe and OMe; R⁵ is H or Me; R⁶ is H; and R⁷ is H. Preferred compounds for reasons of cost, ease of synthesis and/or biological efficacy are: Preferred 1. Compounds of Formula 1 wherein R¹ is Me or Cl;

0020R2 is Cl, Br, CF₃, OCF₂H, OCF₃ or OCH₂CF₃; and R⁴ is H, Me, Et, t-Pr, t-Bu, CH₂CΝ, CH(Me)CH₂SMe or C(Me)₂CH₂SMe.

0021Preferred 2. Compounds of Preferred 1 wherein R2 is Cl, Br, CF₃ or OCH₂CF₃; R⁴ is H, Me, Et or z^'-Pr; and R⁵ is H. Of note are compounds of Preferred 1 and Preferred 2 wherein R⁶ is H; and R⁷ is H.

0022The preferred compositions ofthe present invention are those, which comprise the above preferred compounds. The preferred methods of use are those involving the above- preferred compounds.

0023The compounds of Formula 1 can be prepared by one or more ofthe following methods and variation as described in Schemes 1- 20. The definitions of R¹, R², R³, R⁴, and R⁵ in the compounds of Formulae 1-24 below are as defined above in the Summary ofthe Invention unless indicated otherwise. Compounds of Formula 1 can be prepared by the reaction of benzoxazinones of Formula 2 with an arnine of Formula HNR R⁵ as outlined in Scheme 1. This reaction can be run neat or in a variety of suitable solvents cluding tefrahydrofuran, diethyl ether, dioxane, toluene, dichloromethane or chloroform with optimum temperatures ranging from room temperature to the reflux temperature ofthe solvent. The general reaction of benzoxazinones with amines to produce anthranilamides is well documented in the chemical literature. For a review of benzoxazinone chemistry see Jakobsen et al., Biorganic and Medicinal Chemistry 2000, 8, 2095-2103 and references cited within. See also G. M. Coppola, J. Heterocyclic Chemistry 1999, 36, 563-588.

0024Scheme 1

0025<img file="EP1599463A1_D0003.tif" />

0026Compounds of Formula 1 can also be prepared from haloanthranilic diamides of Formula 3 (wherein X is halogen, preferably iodine or bromine) by the coupling method shown in Scheme 2. Reaction of a compound of Formula 3 with a metal cyanide (e.g. cuprous cyanide, zinc cyanide, or potassium cyanide), optionally with or without a suitable palladium catalyst [e.g. tetrakis(triphenylphosphine)palladium(0) or dichlorobis(triphenylphosphine) palladium(ll)] and optionally with or without a metal halide (e.g. cuprous iodide, zinc iodide, or potassium iodide) in a suitable solvent such as acetonitrile, N,N-dimethylformamide or N-methylpyrrolidinone, optionally at temperatures ranging from room temperature to the reflux temperature ofthe solvent, affords compounds of Formula 1. The suitable solvent can also be tetrahydrofuran or dioxane when palladium catalyst is used in the coupling reaction. <img file="EP1599463A1_D0004.tif" />

00273 (X is Halogen) 1

0028Cyanobenzoxazinones of Formula 2 can be prepared by the method outlined in Scheme 3. Reaction of a halobenzoxazinone of Formula 4 (wherein X is halogen, preferably iodine or bromine) with a metal cyanide using a similar coupling method as described above for Scheme 2 (optionally with or without a palladium catalyst and optionally with or without a metal halide present) affords a compound of Formula 2.

0029Scheme 3

0030<img file="EP1599463A1_D0005.tif" />

0031Cyanobenoxazinones of Formula 2 can also be prepared by the method detailed in Scheme 4 via coupling of a pyrazole carboxylic acid of Formula 5 with a cyanoanthranilic acid of Formula 6. This reaction involves sequential addition of methanesulfonyl chloride in the presence of a tertiary amine such as triethylamine or pyridine to a pyrazole carboxylic acid of Formula 5, followed by the addition of cyanoanthranilic acid of Formula 6, followed by a second addition of tertiary amine and methanesulfonyl chloride.

0032Scheme 4

0033<img file="EP1599463A1_D0006.tif" /> 5 4) MeS(0)₂Cl

0034Scheme 5 depicts another method for preparing benzoxazinones of Formula 2 involving coupling an isatoic anhydride of Formula 7 with a pyrazole acid chloride of Formula 8. Solvents such as pyridine or pyridine/acetonitrile are suitable for this reaction. The acid chlorides of Formula 8 are available from the corresponding acids of Formula 5 by known methods such as chlorination with thionyl chloride or oxalyl chloride. Scheme 5

0035pyridine_^<img file="EP1599463A1_D0007.tif" />

0036<img file="EP1599463A1_D0008.tif" />

0037As shown in Scheme 6, haloanthranilic diamides of Formula 3 can be prepared by the reaction of benzoxazinones of Formula 4, wherein X is halogen, with an amine of Formula HNR⁴R⁵ using a similar method as described above for Scheme 1. Conditions for this reaction are similar to those specified in Scheme 1.

0038<img file="EP1599463A1_D0009.tif" />

0039As shown in Scheme 7, halobenzoxazinones of Formula 4 (wherein X is halogen) can be prepared via direct coupling of a pyridylpyrazole carboxylic acid of Formula 5 with a haloanthranilic acid of Formula 9 (wherein X is halogen) by a similar method as described above for Scheme 4. This reaction involves sequential addition of methanesulfonyl chloride in the presence of a tertiary amine such as triethylamine or pyridine to a pyrazolecarboxylic acid of Formula 5, followed by the addition of a haloanthranilic acid of Formula 9, followed by a second addition of tertiary amine and methanesulfonyl chloride. This method generally affords good yields ofthe benzoxazinone. Scheme 7

0040<img file="EP1599463A1_D0010.tif" />

00413) tertiary a ine X is halogen

00424) MeS(0)₂Cl As shown in Scheme 8, a halobenzoxazinone of Formula 4 can also be prepared via coupling an isatoic anliydride of Formula 10 (wherein X is halogen) with a pyrazole acid chloride of Formula 8 by a similar method as described above for Scheme 5.

0043Scheme 8

0044<img file="EP1599463A1_D0011.tif" />

0045Cyanoanthranilic acids of Formula 6 can be prepared from haloanthranilic acids of Formula 9 as outlined in Scheme 9. Reaction of a haloanthranilic acid of Formula 9 (wherein X is halogen) with a metal cyanide using the same coupling procedure described above for Scheme 2 (optionally with or without a palladium catalyst and optionally with or without a metal halide present) affords a compound of Formula 6.

0046Scheme 9

0047metal cyamde solvent

0048Pd Catalyst (optional) <img file="EP1599463A1_D0012.tif" /> metal halide (optional) <img file="EP1599463A1_D0013.tif" />

0049X is halogen As illustrated in Scheme 10, cyanoisatoic anhydrides of Formula 7 can be prepared from cyanoanthramlic acids of Formula 6 by reaction with phosgene (or a phosgene equivalent such as triphosgene) or an alkyl chloro formate (e.g. methyl chloroformate) in a suitable solvent such as toluene or tetrahydrofuran.

0050Scheme 10

0051<img file="EP1599463A1_D0014.tif" />

0052As shown in Scheme 11, haloanthranilic acids of Formula 9 can be prepared by direct halogenation of an unsubstituted anthranilic acid of Formula 11 with N-chlorosuccinimide (ΝCS), N-bromosuccinimide (ΝBS) or N-iodosuccinimide (ΝIS) respectively in solvents such as N,N-dimethylformamide (DMF) to produce the corresponding halogen-substituted acid of Formula 9.

0053Scheme 11

0054halosuccinimde solvent <img file="EP1599463A1_D0015.tif" /><img file="EP1599463A1_D0016.tif" />

005511

0056As illustrated in Scheme 12, haloisatoic anhydrides of Formula 10 can be prepared from haloanthranilic acids of Formula 9 by reaction with phosgene (or a phosgene equivalent such as triphosgene) or an alkyl chloroformate, e.g. methyl chloroformate, in a suitable solvent such as toluene or tefrahydrofuran.

0057Scheme 12

0058<img file="EP1599463A1_D0017.tif" />

00599 10

0060Pyridylpyrazole carboxylic acids of Formula 5 can be prepared by the method outlined in Scheme 13. Reaction of pyrazole 12 with a 2-halopyridine of Formula 13 in the presence of a suitable base such as potassium carbonate in a solvent such as N,N-dimethylformamide or acetonitrile affords good yields ofthe 1 -pyridylpyrazole 14 with good specificity for the desired regiochemistry. Metallation of 14 with lithium diisopropylamide (LDA) followed by quenching ofthe lithium salt with carbon dioxide affords the pyrazole carboxylic acid of Formula 5.

0061Scheme 13

0062<img file="EP1599463A1_D0018.tif" />

0063The starting pyrazoles 12 wherein R² is CF₃, Cl or Br are known compounds. Pyrazole 12 wherein R² is CF₃ can be prepared by literature procedures (J. Fluorine Chem. 1991, 53(1), 61-70). Pyrazoles 12 wherein R² is Cl or Br can also be prepared by literature procedures (H. Reimlinger and A. Nan Overstraeten, Chem. Ber. 1966, 99(10), 3350-7). A useful alternative method for the preparation of 12 wherein R² is Cl or Br is depicted in Scheme 14. Metallation ofthe sulfamoyl pyrazole 15 with n-butyllithium followed by direct halogenation ofthe anion with either hexachloroethane (for R² being Cl) or 1,2-dibromo- tetrachloroethane (for R² being Br) affords the halogenated derivatives 16 (where R² is Cl or Br). Removal ofthe sulfamoyl group with trifluoroacetic acid (TFA) at room temperature proceeds cleanly and in good yield to afford the pyrazoles 12 wherein R² is Cl or Br respectively.

0064Scheme 14

0065<img file="EP1599463A1_D0019.tif" />

006615 16

0067As an alternative to the method illustrated in Scheme 13, pyrazolecarboxylic acids of Formula 5 wherein R² is CF₃ can also be prepared by the method outlined in Scheme 15. Reaction of a compound of Formula 17 (wherein R⁸ is C1-C4 alkyl) with a suitable base in a suitable organic solvent affords the cyclized product of Formula 18 after neutralization with an acid such as acetic acid. Scheme 15

0068<img file="EP1599463A1_D0020.tif" />

0069The suitable base can be, for example but not limited to, sodium hydride, potassium t- butoxide, dimsyl sodium (CH₃S(O)CH2-Na⁺), alkali metal (such as lithium, sodium or potassium) carbonates or hydroxides, tetraalkyl (such as methyl, ethyl or butyl) ammonium fluorides or hydroxides, or 2-tert-butylimino-2-diethylamino-l,3-dimethyl-perhydro-l,3,2- diazaphosphonine. The suitable organic solvent can be, for example but not limited to, acetone, acetonitrile, tetrahydrofuran, dichloromethane, dimethylsulfoxide, or N,N- dimethylformamide. The cyclization reaction is usually conducted in a temperature range from about 0 to 120 °C. The effects of solvent, base, temperature and addition time are all interdependent, and choice of reaction conditions is important to minimize the formation of byproducts. A preferred base is tetrabutylammonium fluoride.

0070Dehydration ofthe compound of Formula 18 to give the compound of Formula 19, followed by hydrolysis ofthe carboxylic ester function to carboxylic acid, affords the compound of Formula 5. The dehydration is accomplished by treatment with a catalytic amount of a suitable acid. This catalytic acid can be, for example but not limited to, sulfuric acid. The reaction is generally conducted using an organic solvent. As one skilled in the art will realize, dehydration reactions may be conducted in a wide variety of solvents, e.g. acetic acid, in a temperature range generally between about 0 and 200 °C, more preferably between about 0 and 100 °C. Carboxylic esters of Formula 19 can be converted to carboxylic acids of Formula 5 by numerous methods including nucleophilic cleavage under anhydrous conditions or hydrolytic methods involving the use of either acids or bases (see T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 2nd ed., John Wiley &amp; Sons, Inc., New York, 1991, pp. 224—269 for a review of methods). For the method of Scheme 15, base-catalyzed hydrolytic methods are preferred. Suitable bases include alkali metal (such as lithium, sodium or potassium) hydroxides. For example, the ester can be dissolved in a mixture of water and an alcohol such as ethanol. Upon treatment with sodium hydroxide or potassium hydroxide, the ester is saponified to provide the sodium or potassium salt ofthe carboxylic acid. Acidification with a strong acid, such as hydrochloric acid or sulfuric acid, yields the carboxylic acid of Formula 5.

0071Compounds of Formula 17 wherein R² is CF₃ can be prepared by the method outlined in Scheme 16. Treatment of a hydrazine compound of Formula 20 with a ketone of Formula CH₃COR2 in a solvent such as water, methanol or acetic acid gives the hydrazone of Formula 21.

0072Scheme 16

0073<img file="EP1599463A1_D0021.tif" /><img file="EP1599463A1_D0022.tif" /> solvent acid scavenger

0074<img file="EP1599463A1_D0023.tif" />

0075<img file="EP1599463A1_D0024.tif" /><img file="EP1599463A1_D0025.tif" /> wherein R² is CF₃ and R⁸ is C₁-C₄ alkyl

0076One skilled in the art will recognize that this reaction may require catalysis by an optional acid and may also require elevated temperatures depending on the molecular substitution pattern ofthe hydrazone of Formula 21. Reaction ofthe hydrazone of Formula 21 with an alkyl chlorooxalate in a suitable organic solvent such as, for example but not limited to, dichloromethane or tetrahydro furan in the presence of an acid scavenger such as triethylamine provides the compound of Formula 17. The reaction is usually conducted at a temperature between about 0 and 100 °C. Hydrazine compounds of Formula 20 can be prepared by standard methods, such as by reaction ofthe corresponding halopyridine of Formula 13 with hydrazine.

0077As an alternative to the method illustrated in Scheme 13, pyrazolecarboxylic acids of Formula 5 wherein R² is Cl or Br can also be prepared by the method outlined in Scheme 17. Oxidation ofthe compound of Formula 22, optionally in the presence of acid, gives the compound of Formula 19, wherein R² is Cl or Br. Hydrolysis ofthe carboxylic ester function to the carboxylic acid provides the compound of Formula 5. Scheme 17

0078<img file="EP1599463A1_D0026.tif" /> wherein R is -C₄ alkyl

0079The oxidizing agent for converting a compound of Formula 22 to a compound of Formula 19 can be hydrogen peroxide, organic peroxides, potassium persulfate, sodium persulfate, ammonium persulfate, potassium monopersulfate (e.g., Oxone®) or potassium permanganate. To obtain complete conversion, at least one equivalent of oxidizing agent versus the compound of Formula 22 should be used, preferably between about one to two equivalents. This oxidation is typically carried out in the presence of a solvent. The solvent can be an ether, such as tefrahydrofuran,/?-dioxane and the like, an organic ester, such as ethyl acetate, dimethyl carbonate and the like, or a polar aprotic organic such as N,N- dimethylformamide, acetonitrile and the like. Acids suitable for use in the oxidation step include inorganic acids, such as sulfuric acid, phosphoric acid and the like, and organic acids, such as acetic acid, benzoic acid and the like. One to five equivalents of acid can be used. The preferred oxidant is potassium persulfate and the oxidation is preferably carried out in the presence of sulfuric acid. The reaction can be carried out by mixing the compound of Formula 22 in the desired solvent and, if used, the acid. The oxidant can then be added at a convenient rate. The reaction temperature is typically varied from as low as about 0 °C up to the boiling point ofthe solvent in order to obtain a reasonable reaction time to complete the reaction. Methods suitable for converting the ester of Formula 19 to the carboxylic acid of Formula 5 are already described for Scheme 15.

0080Compounds of Formula 22, wherein R² is halogen and R⁸ is C1-C4 alkyl, can be prepared from the corresponding compounds of Formula 23 as shown in Scheme 18. Scheme 18

0081halogenation

0082<img file="EP1599463A1_D0027.tif" /> wherein R is C₁-C₄ alkyl <img file="EP1599463A1_D0028.tif" />

0083Treatment of a compound of Formula 23 with a halogenating reagent, usually in the presence of a solvent, affords the corresponding halo compound of Formula 22. Halogenating reagents that can be used include phosphorus oxyhalides, phosphorus trihalides, phosphorus pentahalides, thionyl chloride, dihalotrialkylphosphoranes, dihalodipheiiylphosphoranes, oxalyl chloride and phosgene. Preferred are phosphorus oxyhalides and phosphorus pentahalides. To obtain complete conversion, at least 0.33 equivalents of phosphorus oxyhalide versus the compound of Formula 23 should be used, preferably between about 0.33 and 1.2 equivalents. To obtain complete conversion, at least 0.20 equivalents of phosphorus pentahalide versus the compound of Formula 23 should be used, preferably between about 0.20 and 1.0 equivalents. Typical solvents for this halogenation include halogenated alkanes, such as dichloromethane, chloroform, chlorobutane and the like, aromatic solvents, such as benzene, xylene, chlorobenzene and the like, ethers, such as tefrahydro furan, ^» -dioxane, diethyl ether, and the like, and polar aprotic solvents such as acetonitrile, N,N-dimethylformamide, and the like. Optionally, an organic base, such as triethylamine, pyridine, N,N-dimethylaniline or the like, can be added. Addition of a catalyst, such as N,N-dimethylformamide, is also an option. Preferred is the process in which the solvent is acetonitrile and a base is absent. Typically, neither a base nor a catalyst is required when acetonitrile solvent is used. The preferred process is conducted by mixing the compound of Formula 23 in acetonitrile. The halogenating reagent is then added over a convenient time, and the mixture is then held at the desired temperature until the reaction is complete. The reaction temperature is typically between 20 °C and the boiling point of acetonitrile, and the reaction time is typically less than 2 hours. The reaction mass is then neutralized with an inorganic base, such as sodium bicarbonate, sodium hydroxide and the like, or an organic base, such as sodium acetate. The desired product of Formula 22 can be isolated by methods known to those skilled in the art, including crystallization, extraction and distillation.

0084Alternatively, compounds of Formula 22 wherein R² is Br or Cl can be prepared by treating the corresponding compounds of Formula 22 wherein R² is a different halogen (e.g., Cl for making Formula 22 wherein R² is Br) or a sulfonate group such as j>-toluenesulfonate, benzenesulfonate and methanesulfonate with hydrogen bromide or hydrogen chloride, respectively. By this method the R² halogen or sulfonate substituent on the compound of Formula 22 is replaced with Br or Cl from hydrogen bromide or hydrogen chloride, respectively. The reaction is conducted in a suitable solvent such as dibromomethane, dichloromethane, acetic acid, ethyl acetate or acetonitrile. The reaction can be conducted at or near atmospheric pressure or above atmospheric pressure in a pressure vessel. The halogenating reagent can be added in the form of a gas to the reaction mixture containing the Formula 23 compound and solvent. When R² in the starting compound of Formula 22 is a halogen such as Cl, the reaction is preferably conducted in such a way that sparging or other suitable means removes the hydrogen halide generated from the reaction. Alternatively, the halogenating reagent can first be dissolved in an inert solvent in which it is highly soluble (such as acetic acid) before contacting the compound of Formula 23 either neat or in solution. The reaction can be conducted between about 0 and 100 °C, most conveniently near ambient temperature (e.g., about 10 to 40 °C), and more preferably between about 20 and 30 °C. Addition of a Lewis acid catalyst (such as aluminum tribromide for preparing Formula 22 wherein R² is Br) can facilitate the reaction. The product of Formula 22 is isolated by the usual methods known to those skilled in the art, including extraction, distillation and crystallization. Starting compounds of Formula 22 wherein R² is a sulfonate group can be prepared from corresponding compounds of Formula 23 by standard methods such as treatment with a sulfonyl chloride (e.g., -toluenesulfonyl chloride) and base such as a tertiary amine (e.g., triethylamine) in a suitable solvent such as dichloromethane.

0085As an alternative to the method illustrated in Scheme 13, pyrazolecarboxylic acids of Formula 5 wherein R² is haloalkoxy can also be prepared by the method outlined in

0086Scheme 19. A compound of Formula 23 is oxidized to a compound of Formula 24. The reaction conditions for this oxidation are as described for the conversion ofthe compound of Formula 22 to the compound of Formula 19 in Scheme 17. <img file="EP1599463A1_D0029.tif" /> wherein R is haloalkoxy and R is C₁-C₄ alkyl

0087The intermediate of Formula 24 is then alkylated to form a compound of Formula 19 (wherein R² is haloalkoxy) by reaction with an appropriate haloalkylating agent such as a haloalkyl halide or sulfonate. The reaction is conducted in the presence of at least one equivalent of a base. Suitable bases include inorganic bases, such as alkali metal (such as lithium, sodium or potassium) carbonates, hydroxides and hydrides or organic bases, such as triethylamine, diisopropylethylamine and l,8-diazabicyclo[5.4.0]undec-7-ene. The reaction is generally conducted in a solvent, which can comprise alcohols, such as methanol and ethanol, halogenated alkanes, such as dichloromethane, aromatic solvents, such as benzene, toluene and chlorobenzene, ethers, such as tefrahydrofuran, and polar aprotic solvents, such as such as acetonitrile, N,N-dimethylformamide, and the like. Alcohols and polar aprotic solvents are preferred for use with inorganic bases. Potassium carbonate as base and N,N-dimethylformamide or acetonitrile as solvent are preferred. The reaction is generally conducted between 0 and 150 °C, most typically between ambient temperature and 100 °C. The ester of Formula 24 can then be converted to the carboxylic acid of Formula 5 by the methods already described for the conversion of a compound of Formula 19 to a compound of Formula 5 in Scheme 15.

0088Compounds of Formula 23 can be prepared from compounds of Formula 20 as outlined in Scheme 20. In this method, a hydrazine compound of Formula 20 is allowed to react with a compound of Formula 25 (a fumarate ester or maleate ester or a mixture thereof can be used) in the presence of a base and a solvent. Scheme 20

0089<img file="EP1599463A1_D0030.tif" /> wherein R is C_rC alkyl <img file="EP1599463A1_D0031.tif" />

0090The base used in Scheme 20 is typically a metal alkoxide salt, such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, potassium tert-butoxide, lithium tert-butoxide, and the like. Polar protic and polar aprotic organic solvents can be used, such as alcohols, acetonitrile, tefrahydrofuran, N,N-dimethyl- formamide, dimethyl sulfoxide and the like. Preferred solvents are alcohols such as methanol and ethanol. It is especially preferred that the alcohol be the same as that making up the fumarate or maleate ester and the alkoxide base. The reaction is typically conducted by mixing the compound of Formula 20 and the base in the solvent. The mixture can be heated or cooled to a desired temperature and the compound of Formula 25 added over a period of time. Typically reaction temperatures are between 0 °C and the boiling point of the solvent used. The reaction may be conducted under greater than atmospheric pressure in order to increase the boiling point ofthe solvent. Temperatures between about 30 and 90 °C are generally preferred. The reaction can then be acidified by adding an organic acid, such as acetic acid and the like, or an inorganic acid, such as hydrochloric acid, sulfuric acid and the like. The desired product of Formula 23 can be isolated by methods known to those skilled in the art, such as crystallization, extraction or distillation.

0091It is recognized that some reagents and reaction conditions described above for preparing compounds of Formula 1 may not be compatible with certain functionalities present in the intermediates. In these instances, the incorporation of protection/deprotection sequences or functional group interconversions into the synthesis will aid in obtaining the desired products. The use and choice ofthe protecting groups will be apparent to one skilled in chemical synthesis (see, for example, T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). One skilled in the art will recognize that, in some cases, after the introduction of a given reagent as it is depicted in any individual scheme, it may be necessary to perform additional routine synthetic steps not described in detail to complete the synthesis of compounds of Formula 1. One skilled in the art will also recognize that it may be necessary to perform a combination ofthe steps illustrated in the above schemes in an order other than that implied by the particular sequence presented to prepare the compounds of Formula 1.

0092Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting ofthe disclosure in any way whatsoever. Steps in the following Examples illustrate a procedure for each step in an overall synthetic transformation, and the starting material for each step may not have necessarily been prepared by a particular preparative run whose procedure is described in other Examples or Steps. Percentages are by weight except for chromatographic solvent mixtures or where otherwise indicated. Parts and percentages for chromatographic solvent mixtures are by volume unless otherwise indicated. ¹H NMR spectra are reported in ppm downfield from tetramethylsilane; "s" means singlet, "d" means doublet, "t" means triplet, "q" means quartet, "m" means multiplet, "dd" means doublet of doublets, "dt" means doublet of triplets, and "br s" means broad singlet. EXAMPLE 1

0093Preparation of 1 -(3 -chloro-2- yridinyl)-N- [4-c yano-2-methyl-6-(aminocarbonyl)phenyl] -3 -

0094(trifluoromethyl)-lH-p azole-5-carboxarnide

0095Step A: Preparation of 2-amino-3-methyl-5-iodobenzoic acid

0096To a solution of 2-amino-3-methylbenzoic acid (Aldrich, 5 g, 33 mmol) in N,N-dimethylformamide (30 mL) was added N-iodosuccinimide (7.8 g, 34.7 mmol), and the reaction mixture was suspended in a 75 °C oil bath overnight. The heat was removed and the reaction mixture was then slowly poured into ice- water (100 mL) to precipitate a light grey solid. The solid was filtered and washed four times with water and then placed in a vacuum oven at 70 °C to dry overnight. The desired intermediate was isolated as a light grey solid (8.8 g).

0097-^•Η ΝMR (OMSO-d₆): δ 7.86 (d,lΗ), 7.44 (d,lH), 2.08 (s,3H).

0098Step B: Preparation of 3-chloro-2-r3-(trifluoromethyl)-lH-pyrazol-l-yllpyridine

0099To a mixture of 2,3-dichloropyridine (99.0 g, 0.67 mol) and 3-(trifluoromethyl)- pyrazole (83 g, 0.61 mol) in dry NJV-dimethylformamide (300 mL) was added potassium carbonate (166.0 g, 1.2 mol) and the reaction was then heated to 110-125 °C over 48 hours. The reaction was cooled to 100 °C and filtered through Celite® diatomaceous filter aid to remove solids. N-N-Dimethylformamide and excess dichloropyridine were removed by distillation at atmospheric pressure. Distillation ofthe product at reduced pressure (b.p. 139-141 °C, 7 mm) afforded 113.4 g ofthe desired intermediate as a clear yellow oil. lΗ MR (CDC1₃): δ 8.45 (d,lΗ), 8.15 (s, 1H), 7.93 (d,lH), 7.36 (t,lH), 6.78 (s,lH). Step C: Preparation of l-(3-cl loro-2-pyridinyl)-3-(trifluoromethyl -lH-pyrazole-

01005-carboxylic acid To a solution of 3-chloro-2-[3-(trifiuoromethyl)-lH-pyrazol-l-yl]pyridine (i.e. the pyrazole product from Step B) (105.0 g, 425 mmol) in dry tetrahydrofuran (700 mL) at -75 °C was added via camiula a -30 °C solution of lithium diisopropylamide (425 mmol) in dry tetrahydrofuran (300 mL). The deep red solution was stirred for 15 minutes, after which time carbon dioxide was bubbled through at -63 °C until the solution became pale yellow and the exothermicity ceased. The reaction was stirred for an additional 20 minutes and then quenched with water (20 mL). The solvent was removed under reduced pressure, and the reaction mixture partitioned between ether and 0.5 N aqueous sodium hydroxide solution. The aqueous extracts were washed with ether (3x), filtered through Celite® diatomaceous filter aid to remove residual solids, and then acidified to a pΗ of approximately 4, at which point an orange oil formed. The aqueous mixture was stirred vigorously and additional acid was added to lower the pΗ to 2.5-3. The orange oil congealed into a granular solid, which was filtered, washed successively with water and 1 N hydrochloric acid, and dried under vacuum at 50 °C to afford 130 g of the title product as an off- white solid. Product from another run following a similar procedure melted at 175-176 °C. ^lΕL NMR (DMSO- ₆): δ 7.61 (s,lΗ)^~7.76 (dd,lH), 8.31 (d,lH), 8.60 (d,lH). Step D: Preparation of 2-ri-(3-chloro-2-pyridinyl -3-(trifluoromethyl -lH-pyrazol-5- yl] -6-iodo-8-methyl-4H-3 , 1 -benzoxazin-4-one

0101To a solution of methanesulfonyl chloride (2.91 mL, 37.74 mmol) in acetonitrile (50 L) was added dropwise a mixture of l-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-lH- pyrazole-5 -carboxylic acid (i.e. the carboxylic acid product of Step C) (10.0 g, 34.31 mmol) and triethylamine (4.78 mL, 34.31 mmol) in acetonitrile (50 mL) at -5 °C. The reaction temperature was then maintained at 0 °C throughout successive addition of reagents. After stirring for 20 minutes, 2-amino-3-methyl-5-iodobenzoic acid (i.e. the product from Step A) (9.51 g, 34.31 mmol) was added and stirring was continued for an additional 10 minutes. A solution of triethylamine (9.56 mL, 68.62 mmol) in acetonitrile (15 mL) was then added dropwise, and the reaction mixture was stirred 30 minutes, followed by the addition of methanesulfonyl chloride (2.91 mL, 37.74 mmol). The reaction mixture was then warmed to room temperature and stirred 2 hours. The solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford 8.53 g ofthe title compound as a yellow solid. !Η NMR (CDC1₃): δ 8.59 (dd,lH), 8.35 (d,lH), 7.97 (dd,lH), 7.86 (d,lH), 7.49 (m,2H), 1.79 (s,3H). Step E: Preparation of 2-ri-(3-chloro-2-pyridinyl)-3-(trifluoromethvD-lH-pyrazol-5- yn-6-cyano-8-metfayl-4H-3.1 -benzoxazin-4-one To a solution of 2-[l-(3-chioro-2-pyridinyl)-3-(trifluoromethyl)-lH-pyrazol-5-yl]-6- iodo-8-methyl-4H-3,l-benzoxazin-4-one (i.e. the benzoxazinone product of Step D) (500 mg, 0.94 mmol) in tetrahydrofuran (10 mL) was added copper(I) iodide (180 mg,

01020.094 mmol), tetrakis(triphenyphosphine)palladium(0) (5.4 mg, 0.047 mmol) and copper(I) cyanide (420 mg, 4.7 mmol) sequentially at room temperature. After heating the reaction mixture at reflux overnight, additional copper(I) cyanide (420 mg, 4.7 mmol), copper(I) iodide (107 mg, 0.56 mmol) and tetrakis(triphenyphosphine)palladium(0) (325 mg, 0.28 mmol) were added and the reflux was continued for 1 hour. The reaction mixture turned black in color, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The reaction mixture was then diluted with ethyl acetate (20 mL) and filtered through Celite®, followed by washing three times with 10% aqueous sodium bicarbonate solution and once with brine. The organic extract was dried (MgSO4) and concentrated under reduced pressure to afford 410 mg ofthe title compound as a crude yellow solid.

0103'Η NMR δ 8.59 (dd,lΗ), 8.33 (d,lH), 8.03 (dd,ΪH), 7.95 (d,lH), 7.56 (m,2H), 1.88 (s,3H). Step F: Preparation of l-(3-chloro-2-pyridinyl)-N-r4-cvano-2-methyl-6- (aminocarbonvDphenyl]- 3-(^"trifluoromethyl)-lH-pyrazole-5-carboxamide

0104To a solution of 2-[l-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-lH-pyrazol-5-yl]-6- cyano-8-methyl-4H-3,l-benzoxazin-4-one (i.e. the cyanobenzoxazinone product of Step E) (200 mg, 0.46 mmol) in tetrahydrofuran (5 mL) was added dropwise ammonium hydroxide (0.5 mL, 12.8 mmol) at room temperature. The reaction mixture was then stirred for five minutes, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The tetrahydrofuran solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford 620 mg ofthe title compound, a compound ofthe present invention, as a solid melting at 200-202 °C. ^lΕL ΝMR (CDC1₃): δ 10.65 (s,lΗ). 8.43 (dd,lH), 7.9 (dd,lH)₃ 7.67 (s.lH), 7.63 (s,lH), 7.45 (m,lH), 7.25 (s,lH), 6.21 (bs,lH), 5.75 (bs.lH), 2.26 (s₅3H). EXAMPLE 2

0105Preparation of l-r3-chloro-2-pyridinyl -N-r4-cyano-2-methyl-6- r(memylamino carbonyl1phenyll-3-(trifluoromethyl)-lH-pyrazole-5-carboxamide

0106Step A: Preparation of l-(3-cMoro-2-pyridinyl -N-[^"4-iodo-2-methyl-6- r(methylamino)carbonyl]phenyl]- 3-(trifluoromethyl)-lH-pyrazole-

01075-carboxamide To a solution of 2-[l-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-lH-pyrazol-5-yl]-6- iodo-8-methyl-4H-3,l-benzoxazin-4-one (i.e. the benzoxazinone product of Example 1, Step D) (500 mg, 0.94 mmol) in tefrahydrofuran (15 mL) was added dropwise methylamine (2.0 M solution in TΗF, 1.4 mL, 2.8 mmol) and the reaction mixture was stirred for 3 hours, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The tefrahydrofuran solvent was evaporated under reduced pressure and the residual solid was purified by chromatography on silica gel to afford 400 mg ofthe title compound as a yellow solid. !Η ΝMR (CDC1₃): δ 10.25 (s,lΗ), 8.45 (dd,lH), 7.85 (dd,lH), 7.55 (s,lH), 7.50 (s,lH), 7.46 (s,lH), 7.40 (m,lH), 6.15 (d,lH), 2.93 (d,3H), 2.12 (s,3H).

0108Step B: Preparation of l-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-

0109[(methylamino)carbonyl^")phenyl^"|- 3-(trifluoromethyl)-lH-pyrazole- 5-carboxamide To a solution of l-(3-chloro-2-pyridinyl)-N-[4-iodo-2-methyl-6-

0110[(me ylamino)carbonyl]phenyl]-3-(trifluoromethyl)-lH-pyrazole-5-carboxamide (i.e. the diamide product of Step A) (410 mg, 0.72 mmol) in tetrahydrofuran (8 mL) was added copper(I) iodide (24 mg, 0.126 mmol), tetrakis(triphenyphosphine)palladium(0) (70 mg, 0.060 mmol) and copper(I) cyanide (640 mg, 7.2 mmol) sequentially at room temperature. The reaction mixture was heated at reflux for 4.5 hours. Thin layer chromatography on silica gel confirmed completion ofthe reaction. The reaction mixture was then diluted with ethyl acetate (20 mL) and filtered through Celite®, followed by washing three times with 10% aqueous sodium bicarbonate solution and once with brine. The organic extract was dried (MgSU4) and concentrated under reduced pressure and the residual solid was purified by chromatography on silica gel to afford 114 mg ofthe title compound, a compound ofthe present invention, as a white solid, melting at 214-216 °C.

0111^•■Η ΝMR (CDCI3): δ 10.70 (s,lΗ), 8.46 (dd,lH), 7.87 (dd,lH), 7.57 (s,2H), 7.45 (m,lH), 7.31 (s,lH), 6.35 (d,lH), 2.98 (d,3H), 2.24 (s,3H). EXAMPLE 3

0112Preparation of 3-chloro-l-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6- [(methylammo carbonyl]phenyll-lH-pyrazole-5-carboxamide

0113Step A: Preparation of 3-chloro-N.N-dimethyl-lH-pyrazole-l-sulfonamide To a solution of N-dimethylsulfamoylpyrazole (188.0 g, 1.07 mol) in dry tetrahydrofuran (1500 mL) at -78 °C was added dropwise a solution of 2.5 M n-butyl- lithium (472 mL, 1.18 mol) in hexane while maintaining the temperature below -65 °C. Upon completion ofthe addition the reaction mixture was maintained at -78 °C for an additional 45 minutes, after which time a solution of hexachloro ethane (279 g, 1.18 mol) in tetrahydrofuran (120 mL) was added dropwise. The reaction mixture was maintained for an hour at -78 °C, warmed to -20 °C and then quenched with water (1 L). The reaction mixture was extracted with methylene chloride (4 x 500 L); the organic extracts were dried over magnesium sulfate and concentrated. The crude product was further purified by chromatography on silica gel using methylene chloride as eluent to afford 160 g ofthe title product compound as a yellow oil.

0114Η ΝMR CDC .): δ 7.61 (s,lΗ), 6.33 (s,lH), 3.07 (d,6H).

0115Step B: Preparation of 3-chloropyrazole

0116To trifluoro acetic acid (290 mL) was added dropwise 3-chloro-N,N-dimethyl- lH-pyrazole-1-sulfonamide (i.e. the chloropyrazole product of Step A) (160 g), and the reaction mixture was stirred at room temperature for 1.5 hrs and then concentrated at reduced pressure. The residue was taken up in hexane, insoluble solids were filtered off, and the hexane was concentrated to afford the crude product as an oil. The crude product was further purified by chromatography on silica gel using ether/hexane (40:60) as eluent to afford 64.44 g ofthe title product as a yellow oil. *H ΝMR (CDC1₃): δ 6.39 (s,lH), 7.66 (s,lH), 9.6 (br s,lH).

0117Step C: Preparation of 3-chloro-2-(3-chloro-lH-pyrazol-l-yl)pyridine

0118To a mixture of 2,3-dichloropyridine (92.60 g, 0.629 mol) and 3-chloropyrazole (i.e. the product of Step B) (64.44 g, 0.629 mol) in N,N-dimethylformamide (400 mL) was added potassium carbonate (147.78 g, 1.06 mol), and the reaction mixture was then heated to 100 °C for 36 hours. The reaction mixture was cooled to room temperature and slowly poured into ice water. The precipitated solids were filtered and washed with water. The solid filter cake was taken up in ethyl acetate, dried over magnesium sulfate and concentrated. The crude solid was chromatographed on silica gel using 20% ethyl acetate/hexane as eluent to afford 39.75 g ofthe title product as a white solid. 1Η ΝMR (CDCI3): δ 6.43 (s,lΗ), 7.26 (m,lH), 7.90 (d,lH), 8.09 (s,lH), 8.41 (d,lH). Step D: Preparation of 3-chloro-l-(3-chloro-2-pyridinyl -lH-pyrazole-5-carboxylic acid To a solution of 3-chloro-2-(3-chloro-lH-pyrazol-l-yl)pyridine (i.e. the pyrazole product of Step C) (39.75 g, 186 mmol) in dry tetrahydrofuran (400 mL) at -78 °C was added dropwise a solution of 2.0 M lithium diisopropylamide (93 mL, 186 mmol) in tetrahydrofuran. Carbon dioxide was bubbled through the amber solution for 14 minutes, after which time the solution became pale brownish-yellow. The reaction was made basic with 1 N aqueous sodium hydroxide solution and extracted with ether (2x500 mL). The aqueous extracts were acidified with 6 N hydrochloric acid followed by extraction with ethyl acetate (3x500 mL). The ethyl acetate extracts were dried over magnesium sulfate and concentrated to afford 42.96 g ofthe title product as an off-white solid. Product from another run following the same procedure melted at 198-199 °C. *Η NMR (DMSO- ₆): δ 6.99 (S,1H), 7.45 (m,lH), 7.93 (d,lH), 8.51 (d,lH). Step E: Preparation of 2-r3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yll-6-iodo- 8-methyl-4H-3 , 1 -benzoxazin-4-one

0119To a solution of methanesulfonyl chloride (0.63 mL, 8.13 mmol) in acetonitrile (10 mL) was added dropwise a mixture of 3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazole-5- carboxylic acid (i.e. the carboxylic acid product of Step D) (2.0 g, 7.75 mmol) and triethylamine (1.08 ml, 7.75 mmol) in acetonitrile (5 mL) at 0 °C. The reaction mixture was then stirred for 15 minutes at 0 °C. Then, 2-amino-3-methyl-5-iodobenzoic acid (i.e. the product from Example 1, Step A) (2.14 g, 7.75 mmol) was added, and stirring was continued for an additional 5 minutes. A solution of triethylamine (2.17 mL, 15.15 mmol) in acetonitrile (5 mL) was then added dropwise while keeping the temperature below 5 °C. The reaction mixture was stirred 40 minutes at 0 °C, and then methanesulfonyl chloride (0.63 mL, 8.13 mmol) was added. The reaction mixture was then warmed to room temperature and stirred overnight. The reaction mixture was then diluted with water • (50 mL), and extracted with ethyl acetate (3x50 mL). The combined ethyl acetate extracts were washed successively with 10% aqueous sodium bicarbonate (1x20 mL) and brine (1x20 mL), dried (MgSO .) and concentrated to afford 3.18 g ofthe title product as a crude yellow solid. ^lΕL NMR (CDC1₃): δ 8.55 (dd,lΗ), 8.33 (s,lH), 7.95 (dd,lH), 7.82 (d,lH), 7.45 (m,lH), 7.16 (s,lH), 1.77 (s,3H).

0120Step F: Preparation of 2-[3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yll-6- cyano-8-methyl-4H-3 , 1 -benzoxazin-4-one To a solution of 2-[3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yl]-6-iodo-8- methyl-4H-3,l-benzoxazin-4-one (i.e. the benzoxazinone product of Step E) (600 mg, 1.2 mmol) in tefrahydrofuran (15 mL) was added copper(I) iodide (137 mg, 0.72 mmol), tefralds(1-riphenyρhosphine)palladium(0) (416 mg, 0.36 mmol) and copper(I) cyanide (860 -mg, 9.6 mmol) sequentially at room temperature. The reaction mixture was then heated at reflux overnight. The reaction turned black in color, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The reaction was diluted with ethyl acetate (20 mL) and filtered through Celite®, followed by washing three times with 10% aqueous sodium bicarbonate solution and once with brine. The organic extract was dried (MgSO₄) and concentrated under reduced pressure to afford 397 mg ofthe title compound as a crude yellow solid.

01211H NMR (CDC1₃): δ 8.50 (q-lH), 8.22 (d,lH), 7.90 (dd,lH), 7.67 (d,lH), 7.45 (m,lH), 7.15 (s,lH), 1.79 (s,3H). Step G: Preparation of 3-chloro-l-r3-chloro-2-pyridinyl)-N-r4-cyano-2-methyl-6-

0122(methylamino carbonyl]phenyll-lH-pyrazole-5-carboxamide To a solution of 2-[3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yl]-6-cyano- 8-methyl-4H-3,l-benzoxazin-4-one (e.g. the cyanobenzoxazinone product of Step F) (100 mg, 0.25 mmol) in tetrahydrofuran (5 mL) was added dropwise methylamine (2.0 M solution in TΗF, 0.5 mL, 1.0 mmol) and the reaction mixture was stirred for 5 minutes, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The tetrahydrofuran solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford the title compound, a compound of the present invention, as a white solid (52 mg), which decomposed in the melting apparatus above 140 °C. ^l≡ ΝMR (CDCI3): δ 10.55 (s,lΗ), 8.45 (dd,lH), 7.85 (dd,lH), 7.55 (d,2H), 7.40 (m,lH), 6.97 (d,lH), 6.30 (d,lH), 2.98 (d,3H), 2.24 (d,3H).

0123EXAMPLE 4 Preparation of 3-chloro- 1 -(3-chloro-2-pyridmylVN-[4-cyano-2-methyl-6- (aminocarbonyl)phenyll-lH-pyrazole-5-carboxamide

0124To a solution of 2-[3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yl]-6-cyano- 8-methyl-4H-3.1-benzoxazin-4-one (i.e. the cyano-benzoxazinone product of Example 3, Step F) (100 mg, 0.25 mmol) in tetrahydrofuran (5 mL) was added dropwise ammonium hydroxide (0.5 mL, 12.8 mmol) at room temperature. The reaction mixture was then stirred for five minutes, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The tetrahydrofuran solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford 55 mg ofthe title compound, a compound ofthe present invention, as a white solid that decomposes in the melting apparatus above 255 °C. 1Η ΝMR (CDCI3): δ 10.50 (s,lΗ), 8.45 (dd,lH), 7.85 (dd,lH), 7.66 (d,lH), 7.61 (s,lH), 7.41 (m,lH), 6.95 (s,lH), 6.25 (bs,lH), 5.75 (bs,lH), 2.52 (s,3H). EXAMPLE 5

0125Preparation of 3-bromo-l-(3-chloro-2-pyridinyl)-N-[4-cvano-2-methyl-6- (methylamino)carbonyllphenyll-lH-pyrazole-5-carboxarnide

0126Step A: Preparation of 3 -bromo-N,N-dimethyl- lH-pyrazole- 1 -sulfonamide To a solution of N,N-dimethylsulfamoylpyrazole (44.0 g, 0.251 mol) in dry tefrahydrofuran (500 mL) at -78 °C was added dropwise a solution of n-butyllithium (2.5 M in hexane, 105.5 mL, 0.264 mol) while maintaining the temperature below -60 °C. A thick solid formed during the addition. Upon completion ofthe addition the reaction mixture was maintained for an additional 15 minutes, after which time a solution of 1,2-dibromo- tefrachloroethane (90 g, 0.276 mol) in tefrahydrofuran (150 L) was added dropwise while maintaining the temperature below —70 °C. The reaction mixture turned a clear orange; stirring was continued for an additional 15 minutes. The -78 °C bath was removed and the reaction was quenched with water (600 mL). The reaction mixture was extracted with methylene chloride (4x), and the organic extracts were dried over magnesium sulfate and concentrated. The crude product was further purified by chromatography on silica gel using methylene chloride-hexane (50:50) as eluent to afford 57.04 g ofthe title product as clear colorless oil.

0127*Η ΝMR (CDC1₃): δ 3.07 (d,6H), 6.44 (m,lH), 7.62 (m,lH). Step B: Preparation of 3-bromopyrazole To trifluoroacetic acid (70 mL) was slowly added 3-bromo-N,N-dimethyl-lH- pyrazole-1 -sulfonamide (i.e. the bromopyrazole product of Step A) (57.04 g). The reaction mixture was stirred at room temperature for 30 minutes and then concenfrated at reduced pressure. The residue was taken up in hexane, insoluble solids were filtered off, and the hexane was evaporated to afford the crude product as an oil. The crude product was further purified by chromatography on silica gel using ethyl acetate/dichloromethane (10:90) as eluent to afford an oil. The oil was taken up in dichloromethane, neutralized with aqueous sodium bicarbonate solution, extracted with methylene chloride (3x), dried over magnesium sulfate and concentrated to afford 25.9 g ofthe title product as a white solid, m.p. 61-64 °C. *Η ΝMR (CDCI3): δ 6.37 (d,lΗ), 7.59 (d,lH), 12.4 (br s,lH). Step C: Preparation of 2-f 3 -bromo- lH-pyrazol- 1 -yl -3-chloro yridine

0128To a mixture of 2,3-dichloropyridine (27.4 g, 185 mmol) and 3-bromopyrazole (i.e. the product of Step B) (25.4 g, 176 mmol) in dry N,N-dirnethylformamide (88 mL) was added potassium carbonate (48:6 g, 352 mmol), and the reaction mixture was heated to 125 °C for 18 hours. The reaction mixture was cooled to room temperature and poured into ice water (800 mL). A precipitate formed. The precipitated solids were stirred for 1.5 h, filtered and washed with water (2x100 mL). The solid filter cake was taken up in methylene chloride and washed sequentially with water, IN hydrochloric acid, saturated aqueous sodium bicarbonate solution, and brine. The organic extracts were then dried over magnesium sulfate and concenfrated to afford 39.9 g of a pink solid. The crude solid was suspended in hexane and stirred vigorously for 1 hr. The solids were filtered, washed with hexane and dried to afford the title product as an off-white powder (30.4 g) determined to be > 94 % pure by NMR. This material was used without further purification in Step D. 1H NMR (CDC1₃): δ 6.52 (s,lH), 7.30 (dd,lH), 7.92 (d,lH), 8.05 (s,lH), 8.43 (d,lH).

0129Step D: Preparation of 3-bromo-l-(3-cMoro-2-pyridinyl)-lH-pyrazole-5-carboxylic acid To a solution of 2-(3-bromo-lH-pyrazol-l-yl)-3-chloropyridine (i.e. the pyrazole product of Step C) (30.4 g, 118 mmol) in dry tetrahydrofuran (250 mL) at -76 °C was added dropwise a solution of lithium diisopropylamide (118 mmol) in tefrahydrofuran at such a rate as to maintain the temperature below -71 °C. The reaction mixture was stirred for 15 minutes at -76 °C, and carbon dioxide was then bubbled through for 10 minutes, causing warming to -57 °C. The reaction mixture was warmed to -20 °C and quenched with water. The reaction mixture was concentrated and then taken up in water (1 L) and ether (500 mL), and then aqueous sodium hydroxide solution (1 N, 20 mL) was added. The aqueous extracts were washed with ether and acidified with hydrochloric acid. The precipitated solids were filtered, washed with water and dried to afford 27.7 g ofthe title product as a tan solid. Product from another run following similar procedure melted at 200-201 °C. lΗ NMR (OMSO-d₆): δ 7.25 (s,lΗ), 7.68 (dd,lH), 8.24 (d,lH), 8.56 (d,lH). Step E: Preparation of 2-[3-bromo-l-(3-chloro-2 -pyridinyl -lH-pyrazol-5-yll-6-iodo-

01308-methyl-4H-3.1 -benzoxazin-4-one To a solution of methanesulfonyl chloride (0.54 ml, 6.94 mmol) in acetonitrile (15 mL) was added dropwise a mixture of 3-bromo-l-(3-chloro-2-pyridinyl)-lH-pyrazole-5- carboxylic acid (i.e. the carboxylic acid product of Step D) (2.0 g, 6.6 mmol) and triethylamine (0.92 ml, 6.6 mmol) in acetonitrile (5 mL) at 0 °C. The reaction mixture was then stirred for 15 minutes at 0 °C. Then, 2-amino-3-methyl-5-iodobenzoic acid (i.e. the product from Example 1, Step A) (1.8 g, 6.6 mmol) was added, and stirring was continued for an additional 5 minutes. A solution of triethylamine (1.85 mL, 13.2 mmol) in acetonitrile (5 mL) was then added dropwise while keeping the temperature below 5 °C. The reaction mixture was stirred 40 minutes at 0 °C, and then methanesulfonyl chloride (0.54 ml, 6.94 mmol) was added. The reaction mixture was then warmed to room temperature and stirred overnight. The reaction mixture was then diluted with water (50 mL) and extracted with ethyl acetate (3x50 mL). The combined ethyl acetate extracts were washed successively with 10% aqueous sodium bicarbonate (1x20 mL) and brine (1x20 mL), dried (MgSO4) and concenfrated to afford 2.24 g ofthe title product as a crude yellow solid.

0131Η NMR CDCls): δ 8.55 (dd,lΗ), 8.33 (d,lH), 7.95 (dd,lH), 7.85 (s,lH), 7.45 (m,lH), 7.25 (s,lH), 1.77 (s,3H). Step F: Preparation of 2-f3-bromo-T-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yll-6- cvano-8-methyl-4H-3 -benzoxazin-4-one To a solution of 2-[3-bromo-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yl]-6-iodo-8- methyl-4H-3,l-benzoxazin-4-one (i.e. the benzoxazinone product of Step E) (600 mg, 1.1 mmol) in tefrahydrofuran (15 mL) was added copper(I) iodide (126 mg, 0.66 mmol), tefr-dds(triphenyphosphine)palladium(0) (382 mg, 0.33 mmol) and copper(I) cyanide (800 mg, 8.8 mmol) sequentially at room temperature. The reaction mixture was then heated at reflux overnight. The reaction turned black in color, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The reaction mixture was diluted with ethyl acetate (20 mL) and filtered through Celite®, followed by washing three times with 10% sodium bicarbonate solution and once with brine. The organic extract was dried (MgSO4) and concentrated under reduced pressure to afford 440 mg ofthe title compound as a crude yellow solid. iΗ NMR (CDC1₃): δ 8.55 (m,lΗ), 8.31 (d,lH), 7.96 (dd,lH), 7.73 (s,lH), 7.51 (m,lH), 7.31 (s,lH), 1.86 (s,3H).

0132Step G: Preparation of 3-bromo-l-(3-chloro-2-pyridinvD-N-f4-cyano-2-methyl-6-

0133[^"(methylamino carbonyllphenyll - lH-p yrazole-5-carboxamide To a solution of 2-[3-bromo-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yl]-6-cyano-8- methyl-4H-3,l-benzoxazin-4-one (i.e. the cyanobenzoxazinone product of Step F) (100 mg, 0.22 mmol) in tetrahydrofuran (5 mL) was added dropwise methylamine (2.0 M solution in TΗF, 0.5 mL, 1.0 mmol) and the reaction mixture was stirred for 5 minutes, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The tetrahydrofuran solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford the title compound, a compound ofthe present invention, as a white solid (41 mg), which decomposed in the melting apparatus above 180 °C. iΗ MR ^DClg): δ 10.55 (s,lΗ), 8.45 (dd,lH), 7.85 (dd,lH), 7.57 (s,2H), 7.37 (m,lH), 7.05 (s,lH), 6.30 (d,lH), 2.98 (d,3H), 2.24 (s,3H).

0134EXAMPLE 6 Preparation of 3-bromo-l-(3-chloro-2-pyridinyl)-N- 4-cvano-2-methyl-6-

0135(aminocarbonyl phenyl]- -lH-pyrazole-5-carboxamide To a solution of 2-[3-bromo-l-(3-cMoro-2-pyridinyl)-lH-pyrazol-5-yl]-6-cyano-8- methyl-4H-3,l-benzoxazin-4-one (i.e. the cyanobenzoxazinone product of Example 5, Step F) (100 mg, 0.22 mmol) in tefrahydrofuran (5 mL) was added dropwise ammonium hydroxide (0.5 mL, 12.8 mmol) at room temperature. The reaction mixture was then stirred for five minutes, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The tefrahydrofuran solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford the title compound, a compound ofthe present invention, as a white solid (36 mg), with a melting point above 255 °C.

0136Η NMR (CDC1₃): δ 10.52 (s, 1H), 8.45 (dd, 1H), 7.85 (dd, 1H), 7.65(s,lH), 7.60 (s,lH), 7.40 (m,lH), 7.05 (s,lH), 6.20 (bs,lH), 5.75 (bs,lH), 2.25 (s,3H). EXAMPLE 7

0137Preparation of 3 -chloro- 1 -(3 -chloro-2-pyridinyl)-N- [^"2-chloro-4-cyano-6- r memylammo carbonyllphenyl]-lH-pyrazole-5-carboxamide

0138Step A: Preparation of 2-amino-3-chloro-5-iodobenzoic acid

0139To a solution of 2-amino-3-chlorobenzoic acid (Aldrich, 5 g, 29.1 mmol) in N,N-dimethylformamide (30 mL) was added N-iodosuccinimide (5.8 g, 26 mmol) and the reaction mixture was heated at 60 °C overnight. The heat was removed and the reaction mixture was then slowly poured into ice-water (100 mL) to precipitate a light brown solid. The solid was filtered and washed four times with water and then placed in a vacuum oven at 70 °C to dry overnight. The desired intermediate was isolated as a light brown solid (7.2 g). !Η ΝMR (DMSO-d): δ 7.96 (d,lΗ), 7.76 (t,lH).

0140Step B: Preparation of 8-chloro-2-r3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyr azol-

01415-yl] -6-iodo-4H-3 , 1 -benzoxazin-4-one To a solution of methanesulfonyl chloride (0.31 mL, 4.07 mmol) in acetonitrile (10 mL) was added dropwise a mixture of 3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazole-5- carboxylic acid (i.e. the carboxylic acid product of Example 3, Step D) (1.0 g, 3.87 mmol) and triethylamine (0.54 mL, 3.87 mmol) in acetonitrile (5 mL) at 0 °C. The reaction mixture was then stirred for 15 minutes at 0 °C. Then, 2-amino-3-chloro-5-iodobenzoic acid (i.e. the product from Step A) (1.15 g, 3.87 mmol) was added, and stirring was continued for an additional 5 minutes. A solution of triethylamine (1.08 mL, 7.74 mmol) in acetonitrile (5 mL) was then added dropwise while keeping the temperature below 5 °C. The reaction mixture was stirred 40 minutes at 0 °C, and then methanesulfonyl chloride (0.31 mL, 4.07 mmol) was added. The reaction mixture was then warmed to room temperature and stirred overnight. The reaction mixture was then diluted with water (50 mL) and extracted with ethyl acetate (3x50 mL). The combined ethyl acetate extracts were washed successively with 10% aqueous sodium bicarbonate (1x20 mL) and brine (1x20 mL), dried (MgSU4) and concentrated under reduced pressure. The residual solid was purified by chromatography on silica gel to afford 575 mg ofthe title compound as a crude yellow solid. !Η ΝMR (CDCI3): δ 8.55 (q , 1Η), 8.39 (d, 1Η), 8.04 (d, 1Η), 7.94 (dd, 1Η), 7.45 (m, 1Η), 7.19 (s, 1Η). Step C: Preparation of 8-chloro-2- 3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazol-

01425-vH-6-cyano-4H-3,l-benzoxazin-4-one To a solution of 8-cMoro-2-[3-chloro-l-(3-cMoro-2-pyridinyl)-lH-ρyrazol-5-yl]-6- iodo-4H-3,l-benzoxazin-4-one (i.e. the benzoxazinone product of Step B) (575 mg, 1.1 mmol) in tetrahydrofuran (15 mL) was added copper(I) iodide (840 mg, 0.44 mmol), tetrakis(triphenyphosphine)palladium(0) (255 mg, 0.22 mmol) and copper(I) cyanide (500 mg, 5.5 mmol) sequentially at room temperature. The reaction mixture was then heated at reflux overnight. The reaction turned black in color, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The reaction was diluted with ethyl acetate (20 mL) and filtered through Celite®, followed by washing three times with 10% aqueous sodium bicarbonate solution and once with brine. The organic extract was dried (MgSO4) and concenfrated under reduced pressure to afford 375 mg ofthe title compound as a crude yellow solid. 1H NMR (CDC1₃): δ 8.55 (q, 1H), 8.36 (d, 1H), 7.95 (m, 2H), 7.5 (m, 1H).

0143Step D: Preparation of 3 -chloro- 1 -(3 -chloro-2-p yridinyl)-N-[2-chloro-4-cyano-6- r(methylamino)carbonyllphenyll-lH-pyrazole-5-carboxamide To a solution of 8-chloro-2-[3-chloro-l-(3-chloro-2-pyridinyl)-lH-pyrazol-5-yl]-6- cyano-4H-3,l-benzoxazin-4-one (i.e. the cyanobenzoxazinone product of Step C) (187 mg, 0.446 mmol) in tetrahydrofuran (5 mL) was added dropwise methylamine (2.0 M solution in TΗF, 0.5 mL, 1.0 mmol) and the reaction mixture was stirred for 5 minutes, at which point thin layer chromatography on silica gel confirmed completion ofthe reaction. The tetrahydrofuran solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford 49 mg ofthe title compound, a compound ofthe present invention, as a white solid that melted at 197-200 °C.

0144Η ΝMR CDC .): δ 10.05 (bs,lΗ), 8.45 (q,lH), 7.85 (dd,lH), 7.70 (d,lH), 7.59 (d,lH), 7.38 (m,lH), 7.02 (s,lH), 6.35 (d,lH), 2.94 (d,3H).

0145By the procedures described herein together with methods known in the art, the following compounds of Table 1 can be prepared. The following abbreviations are used in the Tables which follow: t means tertiary, s means secondary, n means normal, i means iso, Me means methyl, Et means ethyl, Pr means propyl, z^'-Pr means isopropyl, Bu means butyl and CΝ is cyano.

0146Table 1

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0157Formulation/Utility

0158Compounds of this invention will generally be used as a formulation or composition with a carrier suitable for agronomic or nonagronomic use comprising at least one of a liquid diluent, a solid diluent or a surfactant. The formulation or composition ingredients are selected to be consistent with the physical properties ofthe active ingredient, mode of application and environmental factors such as soil type, moisture and temperature. Useful formulations include liquids such as solutions (including emulsifiable concentrates), suspensions, emulsions (including microemulsions and/or suspoemulsions) and the like which optionally can be thickened into gels. Useful formulations further include solids such as dusts, powders, granules, pellets, tablets, films, and the like which can be water-dispersible ("wettable") or water-soluble. Active ingredient can be (micro)encapsulated and further formed into a suspension or solid formulation; alternatively the entire formulation of active ingredient can be encapsulated (or "overcoated"). Encapsulation can control or delay release ofthe active ingredient. Sprayable formulations can be extended in suitable media and used at spray volumes from about one to several hundred liters per hectare. High-strength compositions are primarily used as intermediates for further formulation.

0159The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges that add up to 100 percent by weight. Weight Percent

0160Active lnsredient Diluent Surfactant

0161Water-Dispersible and Water-soluble 5-90 0-94 1-15 Granules, Tablets and Powders.

0162Suspensions, Emulsions, Solutions 5-50 40-95 0-15 (including Emulsifiable Concentrates)

0163Dusts 1-25 70-99 0-5

0164Granules and Pellets 0.01-99 5-99.99 0-15

0165High Strength Compositions 90-99 0-10 0-2

0166Typical solid diluents are described in Watkins, et al., Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, New Jersey. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., friterscience, New York, 1950. McCutcheon 's Detergents and Emulsifiers Annual, Allured Publ. Corp., Ridgewood, New Jersey, as well as Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth and the like, or thickeners to increase viscosity.

0167Surfactants include, for example, polyethoxylated alcohols, polyethoxylated alkylphenols, polyethoxylated sorbitan fatty acid esters, dialkyl sulfosuccinates, alkyl sulfates, alkylbenzene sulfonates, organosilicones, N,N-dialkyltaurates, lignin sulfonates, naphthalene sulfonate formaldehyde condensates, polycarboxylates, and polyoxyethylene/polyoxypropylene block copolymers. Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, starch, sugar, silica, talc, diatomaceous earth, urea, calcium carbonate, sodium carbonate and bicarbonate, and sodium sulfate. Liquid diluents include, for example, water, N,N-dimethylformamide, dimethyl sulfoxide, N-alkylpyrrolidone, ethylene glycol, polypropylene glycol, paraffins, alkylbenzenes, alkylnaphthalenes, oils of olive, castor, linseed, tung, sesame, corn, peanut, cotton-seed, soybean, rape-seed and coconut, fatty acid esters, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, and alcohols such as methanol, cyclohexanol, decanol and tetrahydrofiirfuryl alcohol.

0168Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. Dusts and powders can be prepared by blending and, usually, grinding as in a hammer mill or fluid-energy mill. Suspensions are usually prepared by wet-milling; see, for example, U.S. 3,060,084. Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning, "Agglomeration", Chemical Engineering, December 4, 1967, pp 147-48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, pages 8-57 and following, and PCT Publication WO 91/13546. Pellets can be prepared as described in U.S. 4,172,714. Water-dispersible and water-soluble granules can be prepared as taught in U.S. 4,144,050, U.S. 3,920,442 and DE 3,246,493. Tablets can be prepared as taught in U.S. 5,180,587, U.S. 5,232,701 and U.S. 5,208,030. Fihns can be prepared as taught in GB 2,095,558 and U.S. 3,299,566.

0169For further information regarding the art of formulation, see T. S. Woods, "The Formulator's Toolbox - Product Forms for Modern Agriculture" in Pesticide Chemistry and Bioscience, The Food-Environment Challenge, T. Brooks and T. R. Roberts, Eds., Proceedings ofthe 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120-133. See also U.S. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10-41; U.S. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; U.S. 2,891,855, Col. 3, line 66 tlirough Col. 5, line 17 and Examples 1-4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81-96; and Hance et al, Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989.

0170In the following Examples, all percentages are by weight and all formulations are prepared in conventional ways. Compound numbers refer to compounds in Index Table A.

0171Example A Wettable Powder

0172Compound 1 65.0% dodecylphenol polyethylene glycol ether 2.0% sodium ligninsulfonate 4.0% sodium silicoaluminate 6.0% montmorillonite (calcined) 23.0%.

0173Example B

0174Granule

0175Compound 1 10.0% attapulgite granules (low volatile matter, 0.71/0.30 mm; U.S.S. No. 25-50 sieves) 90.0%.

0176Example C Extruded Pellet

0177Compound 1 25.0%> anhydrous sodium sulfate 10.0% crude calcium ligninsulfonate 5.0% sodium alkylnaphthalenesulfonate 1.0% calcium/magnesium bentonite 59.0%. Example D Emulsifiable Concentrate

0178Compound 1 20.0% blend of oil soluble sulfonates and polyoxyethylene ethers 10.0% isophorone 70.0%.

0179Example E Granule

0180Compound 1 0.5% cellulose 2.5% lactose 4.0% cornmeal 93.0%.

0181Compounds of this invention are characterized by favorable metabolic and/or soil residual patterns and exhibit activity controlling a spectrum of agronomic and non- agronomic invertebrate pests. Compounds of this invention are also characterized by favorable foliar and or soil-applied systemicity in plants exhibiting franslocation to protect foliage and other plant parts not directly' contacted with insecticidal compositions comprising the present compounds. (In the context of this disclosure "invertebrate pest control" means inhibition of invertebrate pest development (including mortality) that causes significant reduction in feeding or other injury or damage caused by the pest; related expressions are defined analogously.) As referred to in this disclosure, the term "invertebrate pest" includes arthropods, gastropods and nematodes of economic importance as pests. The term "arthropod" includes insects, mites, spiders, scorpions, centipedes, millipedes, pill bugs and symphylans. The term "gastropod" includes snails, slugs and other Stylommatophora. The term "nematode" includes all ofthe helminths, such as: roundworms, heartworms, and phytophagous nematodes (Nematoda), flukes (Trematoda), Acanthocephala, and tapeworms (Cestoda). Those skilled in the art will recognize that not all compounds are equally effective against all pests. Compounds of this invention display activity against economically important agronomic and nonagronomic pests. The term "agronomic" refers to the production of field crops such as for food and fiber and includes the growth of cereal crops (e.g., wheat, oats, barley, rye, rice, maize), soybeans, vegetable crops (e.g., lettuce, cabbage, tomatoes, beans), potatoes, sweet potatoes, grapes, cotton, and tree fruits (e.g., pome fruits, stone fruits and citrus fruits). The term "nonagronomic" refers to other horticultural (e.g., forest, greenhouse, nursery or ornamental plants not grown in a field), turf (commercial, golf, residential, recreational, etc.), wood products, public (human) and animal health, domestic and commercial structure, household, and stored product applications or pests. For reason of invertebrate pest control spectrum and economic importance, protection (from damage or injury caused by invertebrate pests) of agronomic crops of cotton, maize, soybeans, rice, vegetable crops, potato, sweet potato, grapes and tree fruit by controlling invertebrate pests are preferred embodiments ofthe invention. Agronomic or nonagronomic pests include larvae ofthe order Lepidoptera, such as armyworms, cutworms, loopers, and heHoti-iines in the family Noctuidae (e.g., fall armyworm (Spodopterafugiperda J. E. Smith), beet armyworm (Spodoptera exigua Hϊϊbner), black cutworm (Agrotis ipsilon Hufnagel), cabbage looper (Trichoplusia ni Hϋbner), tobacco budworm (Heliothis virescens Fabricius)); borers, casebearers, webworms, coneworms, cabbageworms and skeletonizers from the family Pyralidae (e.g., European corn borer (Ostrinia nubilalis Hϋbner), navel orangeworm (Amyelois transitella Walker), corn root webworm (Crambus caliginosellus Clemens), sod webworm (Herpetogramma licarsisalis Walker)); leafrollers, budworms, seed worms, and fruit worms in the family Tortricidae (e.g., codling moth (Cydia pornonella Linnaeus), grape berry moth (Endopiza viteana Clemens), oriental fruit moth (Grapholita molesta Busck)); and many other economically important lepidoptera (e.g., diamondback moth (Plutella xylostella Linnaeus), pink bollworm (Pectinophora gossypiella Saunders), gypsy moth (Lymantria dispar Linnaeus)); nymphs and adults ofthe order Blattodea including cockroaches from the families Blattellidae and Blattidae (e.g., oriental cockroach (Blatta orientalis Linnaeus), Asian cockroach (Blatella asahinai Mizukubo), German cockroach (Blattella germanica Linnaeus), brownbanded cockroach (Supella longipalpa Fabricius), American cockroach (Periplaneta americana Linnaeus), brown cockroach (Periplaneta brunnea Burmeister), Madeira cockroach (Leucophaea maderae Fabricius)); foliar feeding larvae and adults ofthe order Coleoptera including weevils from the families Anthribidae, Bruchidae, and Curculionidae (e.g., boll weevil (Anthonomus grandis Boheman), rice water weevil (Lissorhoptrus orγzophilus Kuschel), granary weevil (Sitophilus gr-anarius Linnaeus), rice weevil (Sitophilus oryzae Linnaeus)); flea beetles, cucumber beetles, rootworms, leaf beetles, potato beetles, and leafminers in the family Chrysomelidae (e.g., Colorado potato beetle (Leptinotarsa decemlineata Say), western corn rootworrn (Diabrotica virgifera virgifera LeConte)); chafers and other beetles from the family Scaribaeidae (e.g., Japanese beetle (Popilliajaponica Newman) and European chafer (Rhizotrogus majalis Razo mowsky)), carpet beetles from the family Dermestidae; wireworms from the family Elateridae; bark beetles from the family Scolytidae and flour beetles from the family Tenebrionidae. In addition agronomic and nonagronomic pests include: adults and larvae of the order Dermaptera including earwigs from the family Forficuhdae (e.g., European earwig (Forficula auricularia Linnaeus), black earwig (Chelisoches rnorio Fabricius)); adults and nymphs ofthe orders Hemiptera and Homoptera such as, plant bugs from the family -Vliridae, cicadas from the family Cicadidae, leafhoppers (e.g. Empoasca spp.) from the family Cicadellidae, planthoppers from the families Fulgoroidae and Delphacidae, treehoppers from the family Membracidae, psyllids from the family Psyllidae, whiteflies from the family Aleyrodidae, aphids from the family Aphididae, phylloxera from the family Phylloxeridae, mealybugs from the family Pseudococcidae, scales from the families Coccidae, Diaspididae and Margarodidae, lace bugs from the family Tingidae, stink bugs from the family Pentatomidae, cinch bugs (e.g., Blissus spp.) and other seed bugs from the family Lygaeidae, spittlebugs from the family Cercopidae squash bugs from the family

0182Coreidae, and red bugs and cotton stainers from the family Pyrrhocoridae. Also included as agronomic and non- agronomic pests are adults and larvae ofthe order Acari (mites) such as spider mites and red mites in the family Tetranychidae (e.g., European red mite (Panonychus ulmi Koch),^" two spotted spider mite (Tetranychus urticae Koch), McDaniel mite (Tetranychus mcdanieli McGregor)), flat mites in the family Tenuipalpidae (e.g., citrus flat mite (Brevipalpus lewisi McGregor)), rust and bud mites in the family Eriophyidae and other foliar feeding mites and mites important in human and animal health, i.e. dust mites in the family Epidermoptidae, follicle mites in the family Demodicidae, grain mites in the family Glycyphagidae, ticks in the order Ixodidae (e.g., deer tick (Ixodes scapularis Say), Australian paralysis tick (Ixodes holocyclus Neumann), American dog tick (Dermacentor variabilis Say), lone star tick (Arnblyomma americanum Linnaeus) and scab and itch mites in the families Psoroptidae, Pyemotidae, and Sarcoptidae; adults and irnmatures ofthe order Orthoptera including grasshoppers, locusts and crickets (e.g., migratory grasshoppers (e.g., Melanoplus sanguinipes Fabricius, M. differentialis Thomas), American grasshoppers (e.g., Schistocerca americana Drury), desert locust (Schistocerca gregaria Forskal), migratory locust (Locusta migratoria Linnaeus), bush locust (Zonocems spp.), house cricket (Acheta domesticus Linnaeus), mole crickets (Gryllotalpa spp.)); adults and irnmatures ofthe order Diptera including leafminers, midges, fruit flies (Tephritidae), frit flies (e.g., Oscinella frit Linnaeus), soil maggots, house flies (e.g., Musca domestica Linnaeus), lesser house flies (e.g., Fannia canicularis Linnaeus, F. femoralis Stein), stable flies (e.g., Stomoxys calcitrans Linnaeus), face flies, horn flies, blow flies (e.g., Chrysomya spp., Phormia spp.), and other muscoid fly pests, horse flies (e.g., Tabanus spp.), bot flies (e.g., Gastrophilus spp., Oestr-us spp.), cattle grubs (e.g., Hypoderma spp.), deer flies (e.g., Chrysops spp.), keds (e.g., Melophagus ovinus Linnaeus) and other Brachycera, mosquitoes (e.g., Aedes spp., Anopheles spp., Culex spp.), black flies (e.g., Prosimulium spp., Simulium spp.), biting midges, sand flies, sciarids, and other Nematocera; adults and irnmatures ofthe order Thysanoptera including onion thrips (Thrips tabaci Lindeman), flower thrips (Frankliniella spp.), and other foliar feeding thrips; insect pests ofthe order Hymenoptera including ants (e.g., red carpenter ant (Camponotus ferrugineus Fabricius), black carpenter ant (Camponotus pennsylvanicus De Geer), Pharaoh ant (Monomorium pharaonis Linnaeus), little fire ant (Wasmannia auropunctata Roger), fire ant (Solenopsis geminata Fabricius), red imported fire ant (Solenopsis invicta Buren), -Argentine ant (Iridomyrmex humilis Ma r), crazy ant (Paratrechina longicornis Latreille), pavement ant (Tetramorium caespitum Linnaeus), cornfield ant (Lasius alienus Forster), odorous house ant (Tapinoma sessile Say)), bees (mcluding carpenter bees), hornets, yellow jackets, wasps, and sawflies (Neodiprion spp.; Cephus spp.); insect pests ofthe order Isoptera including the eastern subterranean termite (Reticulitermes flavipes Kollar), western subterranean termite (Reticulitermes hespe s Banks), Formosan subterranean termite (Coptotermes formosanus Shiraki), West Indian drywood termite (Incisitermes immigrans Snyder) and other termites of economic importance; insect pests ofthe order Thysanura such as silverfish (Lepisma saccharina Linnaeus) and firebrat (Thermobia domestica Packard); insect pests ofthe order Mallophaga and including the head louse (Pediculus humanus capitis De Geer), body louse (Pediculus humanus humanus Linnaeus), chicken body louse (Menacanthus stramineus Nitszch), dog biting louse (Trichodectes canis De Geer), fluff louse (Goniocotes gallinae De Geer), sheep body louse (Bovicola ovis Schrank), short-nosed cattle louse (Haematopinus eurysternus Nitzsch), long-nosed cattle louse (Linognathus vituli Linnaeus) and other sucking and chewing parasitic lice that attack man and animals; insect pests ofthe order Siphonoptera including the oriental rat flea (Xenopsylla cheopis Rothschild), cat flea (Ctenocephalides felis Bouche), dog flea (Ctenocephalides canis Curtis), hen flea (Ceratophyllus gallinae Schrank), sticktight flea (Echidnophaga gallinacea Westwood), human flea (Pulex irritans Linnaeus) and other fleas afflicting mammals and birds. Additional invertebrate pests covered include: spiders in the order Araneae such as the brown recluse spider (Loxosceles reclusa Gertsch &amp; Mulaik) and the black widow spider (Latrodectus mactans Fabricius), and centipedes in the order Scutigeromorpha such as the house centipede (Scutigera coleoptrata Linnaeus). Compounds ofthe present invention also have activity on members ofthe Classes Nematoda, Cestoda, Trematoda, and Acanthocephala including economically important members ofthe orders Strongylida, Ascaridida, Oxyurida, Rhabditida, Spirurida, and Enoplida such as but not limited to economically important agricultural pests (i.e. root knot nematodes in the genus Meloidogyne, lesion nematodes in the genus Pratylenchus, stubby root nematodes in the genus Trichodorus, etc.) and animal and human health pests (i.e. all economically important flukes, tapeworms, and roundworms, such as Strongylus vulgaris in horses, Toxocara canis in dogs, Haemonchus contortus in sheep, Dirofilaria immitis Leidy in dogs, Anoplocephala perfoliata in horses, Fasciola hepatica Linnaeus in ruminants, etc.).

0183Compounds ofthe invention show particularly high activity against pests in the order Lepidoptera (e.g., Alabama argillacea Hϋbner (cotton leaf worm), Archips argyrospila Walker (fruit tree leaf roller), A. rosana Linnaeus (European leaf roller) and other Archips species, Chilo suppressalis Walker (rice stem borer), Cnaphalocrosis medinalis Guenee (rice leaf roller), Crambus caliginosellus Clemens (corn root webworm), Crambus teterrellus Zincken (bluegrass webworm), Cydia pomonella Linnaeus (codling moth), Earias insulana Boisduval (spiny bollworm), Earias vittella Fabricius (spotted bollworm), Helicoverpa armigera Hϋbner (American bollworm), Helicoverpa zea Boddie (corn earworm), Heliothis virescens Fabricius (tobacco budworm), Herpetogramma licarsisalis Walker (sod webworm), Lobesia botrana Denis &amp; Schiffermϋller (grape berry moth), Pectinophora gossypiella Saunders (pink bollworm), Phyllocnistis citrella Stainton (citrus leafminer), Pieris brassicae Linnaeus (large white butterfly), Pieris rapae Linnaeus (small white butterfly), Plutella xylostella Linnaeus (diamondback moth), Spodoptera exigua Hϋbner (beet armyworm), Spodoptera litura Fabricius (tobacco cutworm, cluster caterpillar), Spodoptera fi-ugiperda J. E. Smith (fall armyworm), Trichoplusia ni Hϋbner (cabbage looper) and Tuta absoluta Meyrick (tomato leafminer)). Compounds ofthe invention also • have commercially significant activity on members from the order Homoptera including:

0184Acyrthisiphon pisum Harris (pea aphid), Aphis craccivora Koch (cowpea aphid), Aphis fabae Scopoli (black bean aphid), Aphis gossypii Glover (cotton aphid, melon aphid), Aphis pomi De Geer (apple aphid), Aphis spiraecola Patch (spirea aphid), Aulacorthum solani Kaltenbach (foxglove aphid), Chaetosiphon fragaefolii Cockerell (strawberry aphid), Diuraphis noxia Kurdjumov/Mordvilko (Russian wheat aphid), Dysaphis plantaginea Paaserini (rosy apple aphid), Eriosoma lanigerum Hausmann (woolly apple aphid), Hyalopterus pruni Geoffrey (mealy plum aphid), Lipaphis erysimi Kaltenbach (turnip aphid), Metopolophium dirrhodum Walker (cereal aphid), Macrosipum euphorbiae Thomas (potato aphid), Myzus persicae Sulzer (peach-potato aphid, green peach aphid), Nasonovia ribisnigri Mosley (lettuce aphid), Pemphigus spp. (root aphids and gall aphids),

0185Rhopalosiphum maidis Fitch (corn leaf aphid), Rhopalosiphum padi Linnaeus (bird cherry- oat aphid), Schizaphis graminum Rondani (greenbug), Sitobion avenae Fabricius (English grain aphid), TJierioaphis maculata Buckton (spotted alfalfa aphid), Toxoptera aurantii Boyer de Fonscolombe (black citrus aphid), and Toxoptera citricida Kirkaldy (brown citrus aphid); Adelges spp. (adelgids); Phylloxera devastatrix Pergande (pecan phylloxera);

0186Bemisia tabaci Gennadius (tobacco whitefly, sweetpotato whitefly), Bemisia argentifolii Bellows &amp; Perring (silverleaf whitefly), Dialeurodes citri Ashmead (citrus whitefly) and Trialeurodes vaporariorum Westwood (greenhouse whitefly); Empoasca fabae Harris (potato leafhopper), Laodelphax striatellus Fallen (smaller brown planthopper),, Macrolestes quadrilineatus Forbes (aster leafhopper), Nephotettix cinticeps Uhler (green leafhopper),

0187Nephotettix nigr-opictus Stal (rice leafhopper), Nilaparvata lugens Stal (brown planthopper), Peregr'inus maidis Ashmead (corn planthopper), Sogatella furcifera Horvath (white-backed planthopper), Sogatodes orizicola Muir (rice delphacid), Typhlocyba pomaria McAtee white apple leafhopper, Erythroneoura spp. (grape leafhoppers); Magicidada septendecim Linnaeus (periodical cicada); Icerya purchasi Maskell (cottony cushion scale),

0188Quadraspidiotus perniciosus Comstock (San Jose scale); Planococcus citri Risso (citrus mealybug); Pseudococcus spp. (other mealybug complex); Cacopsylla pyricola Foerster (pear psylla), Trioza diospyri Ashmead (persimmon psylla). These compounds also have activity on members from the order Hemiptera including: Acrosternurn hilare Say (green stink bug), Anasa tristis De Geer (squash bug), Blissus leucopterus leucopterus Say (chinch bug), Corythuca gossypii Fabricius (cotton lace bug), Cyrtopeltis modesta Distant (tomato bug), Dysdercus suturellus Herrich-Schaffer (cotton stainer), Euchistus servus Say (brown stink bug), Euchistus variolarius Pahsot de Beauvois (one-spotted stink bug), Graptosthetus spp. (complex of seed bugs), Leptoglossus corculus Say (leaf-footed pine seed bug), Lygus lineolaris Palisot de Beauvois (tarnished plant bug), Nezara viridula Linnaeus (southern green stink bug), Oebalus pugnax Fabricius (rice stink bug), Oncopeltus fasciatus Dallas (large milkweed bug), Pseudatomoscelis seriatus Reuter (cotton fleahopper). Other insect orders controlled by compounds ofthe invention include Thysanoptera (e.g., Frankliniella occidentalis Pergande (western flower thrip), Scirthothrips citri Moulton (citrus thrip), Sericothrips variabilis Beach (soybean thrip), and Thrips tabaci Lindeman (onion thrip); and the order Coleoptera (e.g., Leptinotarsa decemlineata Say (Colorado potato beetle), Epilachna varivestis Mulsant (Mexican bean beetle) and wireworms ofthe genera Agriotes, Athous or Limonius) .

0189Compounds of this invention can also be mixed with one or more other biologically active compounds or agents including insecticides, fungicides, nematocides, bactericides, acaricides, growth regulators such as rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agronomic and non-agronomic utility. Thus the present invention also pertains to a composition comprising a biologically effective amount of a compound of Formula 1 and an effective amount of at least one additional biologically active compound or agent and can further comprise at least one of a surfactant, a solid diluent or a liquid diluent. Examples of such biologically active compounds or agents with which compounds of this invention can be formulated are: insecticides such as abamectin, acephate, acetamiprid, acetoprole, amidoflumet (S-1955), avermectin, azadirachtin, azinphos-methyl, bifenthrin, bifenazate, bistrifluron, buprofezin, carbofuran, chlorfenapyr, chlorfluazuron, chlorpyrifos, chlorpyrifos-methyl, chromafenozide, clothianidin, cyfluthrin. beta-cyfluthrin, cyhalothrin, lambda-cyhalotbrin, cypermethrin, cyromazine, deltamethrin, diafenthiuron, diazinon, diflubenzuron, dimethoate, dinotefuran, diofenolan, emamectin, endosulfan, esfenvalerate, ethiprole, fenothicarb, fenoxycarb, fenpropathrin, fenvalerate, fipronil, flonicamid, flucythrinate, tau-fluvalinate, flufenerim (UR-50701), flufenoxuron, garnma-chalothrin, halofenozide, hexaflumuron, imidacloprid, indoxacarb, isofenphos, lufenuron, malathion, metaldehyde, methamidophos, methidathion, methomyl, methoprene, methoxychlor, methoxyfenozide, metofluthrin, monocrotophos, methoxyfenozide, novaluron, noviflumuron (XDE-007), oxamyl, parathion, parathion-methyl, pemiethrin, phorate, phosalone, phosmet, phosphamidon, pirimicarb, profenofos, profluthrin, protrifenbute, pymetrozine, pyridalyl, pvriproxyfen, rotenone, SI 812 (Nalent) spinosad, spiromesifen (BSΝ 2060), sulprofos, tebufenozide, teflubenzuron, tefluthrin, terbufos, tetrachlorvinphos, thiacloprid, hiamethoxam, thiodicarb, thiosultap-sodium, tolfenpyrad, fralomethrin, trichlorfon and triflumuro.n; fungicides such as acibenzolar, S-methyl, azoxysfrobin, benalazy-M, benthiavalicarb, benomyl, blasticidin-S, Bordeaux mixture (fribasic copper sulfate), boscalid, bromuconazole, buthiobate, carpropamid, captafol, captan, carbendazim, chloroneb, chlorothalonil, clotrimazole, copper oxychloride, copper salts, cymoxanil, cyazofamid, cyflufenamid, cyproconazole, cyprodinil, diclocymet, diclomezine, dicloran, difenoconazole, dimethomorph, dimoxysfrobin, diniconazole, diniconazole-M, dodine, edifenphos, - epoxiconazole, ethaboxam, famoxadone, fenarimol, fenbuconazole, fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, fluazinam, fludioxonil, flumorph, fluoxastrobin, fluquinconazole, flusilazole, flutolanil, fiutriafol, folpet, fosetyl-aluminum, furalaxyl, furametapyr, guazatine, hexaconazole, hymexazol, imazalil, imibenconazole, iminoctadine, ipconazole, iprobenfos,. iprodione, iprovalicarb, isoconazole, isoprothiolane, kasugamycin, kresoxim-methyl, mancozeb, maneb, mefenoxam, mepanapyrim, mepronil, metalaxyl, metconazole, meton-dnosfrobin/fenominostrobin, metrafenone, miconazole, myclobutanil, neo-asozin (ferric methanearsonate), nuarimol, oryzasfrobin, oxadixyl, oxpoconazole, penconazole, pencycuron, picobenzamid, picoxysfrobin, probenazole, prochloraz, propamocarb, propiconazole, proqu nazid, prothioconazole, pyraclosfrobin, pyrimethanil, pyrifenox, pyroquilon, quinoxyfen, silthiofam, simeconazole, sipconazole, spfroxamine, sulfur, tebuconazole, tetraconazole, tiadinil, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tolylfluanid, triadimefon, triadimenol, triarimol, tricyclazole, trifloxystrobin, triflumizole, triforine, triticonazole, uniconazole, validamycin, vinclozolin and zoxamide; nematocides such as aldicarb, oxamyl and fenamiphos; bactericides such as streptomycin; acaricides such as amitraz, chinomethionat, chlorobenzilate, cyhexatin, dicofol, dienochlor, etoxazole, fenazaquin, fenbutatin oxide, fenpropathrin, fenpvroximate, hexythiazox, propargite, pyridaben and tebufenpyrad; and biological agents such as Bacillus thuringiensis including ssp. aizawai and kurstald, Bacillus thuringiensis delta endotoxin, baculovirus, and entomopathogenic bacteria, virus and fungi. Compounds of this invention and compositions thereof can be applied to plants genetically transformed to express proteins toxic to invertebrate pests (such as Bacillus thuringiensis toxin). The effect ofthe exogenously applied invertebrate pest confrol compounds of this invention may be synergistic with the expressed toxin proteins.

0190A general reference for these agricultural protectants is The Pesticide Manual, 12th Edition, C. D. S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, U.K., 2000. ^'

0191Preferred insecticides and acaricides for mixing with compounds of this invention include pyrethroids such as acetarniprid, cypermethrin, cyhalothrin, cyfluthrin, beta- cyfluthrin, esfenvalerate, fenvalerate and fralomethrin; carbamates such as fenothicarb, methomyl, oxamyl and thiodicarb; neonicotinoids such as clot anidin, irnidacloprid and thiacloprid; neuronal sodium channel blockers such as i doxacarb; insecticidal macrocyclic lactones such as spinosad, abamectin, avermectin and emamectin; γ-aminobutyric acid (GABA) antagonists such as endosulfan, ethiprole and fipronil; insecticidal ureas such as^' flufenoxuron and triflumuron; juvenile hormone mimics such as diofenolan and pyriproxyfen; pymetrozine; and amifraz. Preferred biological agents for mixing with compounds of this invention include Bacillus thuringiensis and Bacillus thuringiensis delta endotoxin as well as naturally occurring and genetically modified viral insecticides including members ofthe family Baculoviridae as well as entomophagous fungi.

0192Most preferred mixtures include a mixture of a compound of this invention with cyhalothrin; a mixture of a compound of this invention with beta-cyfluthrin; a mixture of a compound of this invention with esfenvalerate; a mixture of a compound of this invention with methomyl; a mixture of a compound of this invention with irnidacloprid; a mixture of a compound of this invention with thiacloprid; a mixture of a compound of this mvention with indoxacarb; a mixture of a compound of this invention with abamectin; a mixture of a compound of this invention with, endosulfan; a mixture of a compound of this invention with ethiprole; a mixture of a compound of this invention with fipronil; a mixture of a compound of this invention with flufenoxuron; a mixture of a compound of this invention with pyriproxyfen; a mixture of a compound of this invention with pymetrozine; a mixture of a compound of this invention with amifraz; a mixture of a compound of this invention with Bacillus thuringiensis aizawai or Bacillus thuringiensis kurstaki, and a mixture of a compound of this invention with Bacillus thuringiensis delta endotoxin.

0193In certain instances, combinations with other invertebrate pest confrol compounds or agents having a similar spectrum of control but a different mode of action will be particularly advantageous for resistance management. Thus, compositions ofthe present invention can further comprise a biologically effective amount of at least one additional invertebrate pest control compound or agent having a similar spectrum of control but a different mode of action. Contacting a plant genetically modified to express a plant protection compound (e.g., protein) or the locus ofthe plant with a biologically effective amount of a compound of invention can also provide a broader spectrum of plant protection and be advantageous for resistance management.

0194Invertebrate pests are controlled in agronomic and nonagronomic applications by applying one or more ofthe compounds of this invention, in an effective amount, to the environment ofthe pests including the agronomic and/or nonagronomic locus of infestation, to the area to be protected, or directly on the pests to be controlled. Thus, the present invention further comprises a method for the control of invertebrates in agronomic and or nonagronomic applications, comprising contacting the invertebrates or their environment with a biologically effective amount of one or more ofthe compounds of he invention, or with a composition comprising at least one such compound or a composition comprising at least one such compound and an effective amount of at least one additional biologically active compound or agent. Examples of suitable compositions comprising a compound of the invention and an effective amount of at least one additional biologically active compound or agent include granular compositions wherein the additional biologically active compound is present on the same granule as the compound ofthe invention or on granules separate from those ofthe compound of this invention.

0195A preferred method of contact is by spraying. Alternatively, a granular composition comprising a compound ofthe invention can be applied to the plant foliage or the soil. Compounds of this invention are also effectively delivered through plant uptake by contacting the plant with a composition comprising a compound of this invention applied as a soil drench of a liquid formulation, a granular formulation to the soil, a nursery box treatment or a dip of transplants. Compounds are also effective by topical application of a composition comprising a compound of this invention to the locus of infestation. Other methods of contact include application of a compound or a composition ofthe invention by direct and residual sprays, aerial sprays, gels, seed coatings, microencapsulations, systemic uptake, baits, eartags, boluses, foggers, fumigants, aerosols, dusts and many others. The compounds of this invention may also be impregnated into materials for fabricating invertebrate control devices (e.g. insect netting).

0196A compound of this invention can be incorporated into a bait composition that is consumed by an invertebrate pest or used within devices such as traps, bait stations, and the like. Such a bait composition can be in the form of granules which comprise (a) an active ingredient, namely a compound of Formula 1, an N-oxide, or salt thereof, (b) one or more food materials, (c) optionally an atfractant, and (d) optionally one or more humectants. Of note granules or bait compositions which comprise between about 0.001-5% active ingredient; about 40-99% food material and/or atfractant; and optionally about 0.05-10% humectants; are effective in controlling soil invertebrate pests at very low application rates, particularly at doses of active ingredient that are lethal by ingestion rather than by direct contact. Of note some food materials will function both as a food source and an atfractant. Food materials include carbohydrates, proteins and lipids. Examples of food materials are vegetable flour, sugar, starches, animal fat, vegetable oil, yeast extracts and milk solids. Examples of atfractants are odorants and flavorants, such as fruit or plant extracts, perfume, or other animal or plant component, pheromones or other agents known to attract a target invertebrate pest. Examples of humectants, i.e. moisture retaining agents, are glycols and other polyols, glycerine and sorbitol. Of note is a bait composition (and a method utilizing such a bait composition) used to control invertebrate pests including individually or in combinations ants, termites, and cockroaches. A device for controlling an invertebrate pest can comprise the present bait composition and a housing adapted to receive the bait composition, wherein the housing has at least one opening sized to permit the invertebrate pest to pass through the opening so the invertebrate pest can gain access to the bait composition from a location outside the housing, and wherein the housing is further adapted to be placed in or near a locus of potential or known activity for the invertebrate pest.

0197The compounds of this invention can be applied in their pure state, but most often application will be of a formulation comprising one or more compounds with suitable carriers, diluents, and surfactants and possibly in combination with a food depending on the contemplated end use. A preferred method of application involves spraying a water dispersion or refined oil solution ofthe compounds. Combinations with spray oils, spray oil concentrations, spreader stickers, adjuvants, other solvents, and synergists such as piperonyl butoxide often enhance compound efficacy. For nonagronomic uses such sprays can be applied from spray containers such as a can, a bottle or other container, either by means of a pump or by releasing it from a pressurized container, e.g. a pressurized aerosol spray can. Such spray compositions can take various forms, for example, sprays, mists, foams, fumes or fog. Such spray compositions thus can further comprise propellants, foaming agents, etc. as the case may be. Of note is a spray composition comprising a compound or composition of the present invention and a propellant. Representative propellants include, but are not limited to, methane, ethane, propane, iospropane, butane, isobutane, butene, pentane, iospentane, neopentane, pentene, hydrofluorocarbons, chlorofluoroacarbons, dimethyl ether, and mixtures ofthe foregoing. Of note is a spray composition (and a method utilizing such a spray composition dispensed from a spray container) used to confrol an invertebrate pest including individually or in combinations mosquitoes, black flies, stable flies, deer flies, horse flies, wasps, yellow jackets, hornets, ticks, spiders, ants, gnats, and the like. The rate of application required for effective confrol (i.e. "biologically effective amount") will depend on such factors as the species of invertebrate to be controlled, the pest's life cycle, life stage, its size, location, time of year, host crop or animal, feeding behavior, mating behavior, ambient moisture, temperature, and the like. Under normal circumstances, application rates of about 0.01 to 2 kg of active ingredient per hectare are sufficient to control pests in agronomic ecosystems, but as little as 0.0001 kg/hectare may be sufficient or as much as 8 kg/hectare may be required. For nonagronomic applications, effective use rates will range from about 1.0 to 50 mg/square meter but as little as 0.1 mg/square meter may be sufficient or as much as 150 mg/square meter may be required. One skilled in the art can easily determine the biologically effective amount necessary for the desired level of invertebrate pest control.

0198• The following TESTS demonstrate the control efficacy of compounds of this invention on specific pests. "Control efficacy" represents inhibition of invertebrate pest development (including mortality) that causes significantly reduced feeding. The pest confrol protection afforded by the compounds is not limited, however, to these species. See Index Table A, B and C for compound descriptions. The following abbreviations are used in the Index Tables ^" which follow: z is iso, t is tertiary, Me is methyl, Et is ethyl, Pr is propyl, z-Pr is.isopropyl, c-Pr is cyclopropyl, Bu is butyl, and CN is cyano. The abbreviation "Ex." stands for "Example" and is followed by a number indicating in which example/the compound is prepared.

INDEX TABLE A

0200<img file="EP1599463A1_D0040.tif" />

0201Compound Rl l2 R3 El id m.v. PCD l(Ex. 1) Me CF₃ Cl H H 200-202

02022(Ex. 2) Me CF₃ Cl Me H 214-216

02033(Ex. 3) Me Cl Cl Me H *

02044(Ex. ⁴) Me Cl Cl H H >255

0205*

02065(Ex. 5) Me Br Cl Me H

02076(Ex. 6) Me Br Cl H H >255

02087(Ex. 7) Cl Cl Cl Me H 197-200

02098 Me CF₃ Cl z^'-Pr H >250

02109 Cl Cl Cl z^'-Pr H 213-215

021110 Cl Br Cl z^'-Pr H 222-225

021211 Cl Br Cl z^'-Pr Me 224-226

021312 Cl Br Cl Me H 198-201

021413 Cl Cl Cl z^'-Pr Me 238-241

021514 Cl Br Cl H H >255

021615 Cl F Cl z^'-Pr H 162-166

021716 Cl F Cl Me H 205-208

021817 Cl Br F z^'-Pr H •230-232

0219*

022018 Cl Br F Me H

022119 Cl Br F H H >255

022220 Me , CF₃ Cl Me Me 227-230 Comυound Rl 2 . R3 El R m.υ. CO

022321 Cl CF₃ Cl z^'-Pr H 247-249

022422 Cl CF₃ Cl Me H 215-217

022523 Cl CF₃ Cl H H >255 <img file="EP1599463A1_D0041.tif" />

0226*

022725 Me Br Cl z^'-Pr H

022826 Me Cl Cl CH₂CN H 213-215

022927 Me Br Cl CH₂CN H 225-227

023028 Me OCH₂CF₃ Cl Me Me 132-135

023129 Me OCH₂CF₃ Cl Me H 162-165

023230 Me CF₃ Cl t-Bu H >250

023331 Me CF₃ Cl CH₂CN H 250-251

023432 Me CF₃ -Cl Et H 150-151

0235*

023633 Me Cl Cl Et H

023734 Me Cl Cl t-Bu H >255

0238*

023935 Me Br Cl Et H

024036 Me Br Cl t-Bu H >255

024137 Me CF₃ Cl CH(CH₃)CH₂SMe H 208-209

024239 Me Br Cl Me Me 262-264

024340 Me OCH₂CF₃ Cl z^'-Pr H 164-167

0244*

024541 Me OCH₂CF₃ Cl • t-Bu H

024642 Me OCH₂CF₃ Cl Me Me 212-214

024743 Me OCH₂CF₃ Cl Et H 168-171

024844 Me OCH₂CF₃ Cl CH₂CN H 207-211

024945 Me Cl Cl Me Me 261-263

025046 Me CF₃ F ^' Me H 211-212

025147 Me CF₃ F H H 138-139 ^{■ •}

025248 Me CF₃ F Et H 219-220

025349 Me Br F Me H 152-153

025450 Me Br F H H 162-164

025551 Me Br F Et H 201-202

025652 Me CF₃ F z^'-Pr H 229-230

025753 Me Br F z^'-Pr H 159-160

025854 Me CF₃ F CH(CH₃)CH₂SMe H 209-210

025955 F Br Cl Me H 209-210

026063 Me Br Cl CH(CH₃)CH₂SMe H 180-181

026164 Me Cl Cl CH(CH₃)CH₂SMe H 193-194

026265 Me Br Cl C(CH₃)₂CH₂SMe H 161-162 Compound Rl R-_ R-1 £ m.υ. PC.

026366 Me CF₃ Cl C(CH₃)₂CH₂SMe H 250-250

026467 Me Cl Cl C(CH₃)₂CH₂SMe H 234-235

026568 Me CF₃ Cl c-Pr H 159-160

026669 Me CF₃ Cl (CH₂)₂OMe H 206-207

026770 Me Cl Cl c-Pr H 156-157

026871 Me Cl Cl (CH₂)₂OMe H 118-119

026972 Me Br Cl (CH₂)₂OMe H 216-217

027073 Me Br Cl c-Pr H 159-160

027174 Me CF₃ Cl Me H 235-236

027275 Me CF₃ Cl CH₂CH(CH₃)₂ H 257-258

027376 Me Br Cl CH₂(c-Pr) H 223-224

027477 Me Br Cl CH₂CH(CH₃)₂ H 245-246

027578 Me Br Cl CH(CH₃)CH₂S(0)Me H 157-158

027679 Me Br Cl CH(CH₃)CH₂S(0)₂Me H 169-170

027780 Me Cl Cl CH(CH₃)(CH₂)₂SMe H 190-191

027881 Me Br Cl CH(CH₃)(CH₂)₂SMe H 188-190

027982 Me CF₃ Cl CH(CH₃)(CH₂)₂SMe H 134-135

028083 Me Cl Cl CH(CH₃)(CH₂)₂S(0)₂Me H 186-187

028184 Me Br Cl CH(CH₃)(CH₂)₂S(0)₂Me H 182-183

028285 Br Br Cl Me H 214-215

028386 Br Br Cl z'-Pr H 166-167

028487 Br Br Cl CH₂CN H 226-227

028588 Me Cl F Me H 149-150

028689 Me Cl F H H 146-147

028790 Me Cl Br H H 189-190

028891 Me Cl Br Me H 149-150

028992 Me Cl Br z^'-Pr H 119-120

029093 Me Cl Br Me Me 247-248

029194 Me Br Br H H 255-256

029295 Me Br Br Me H 183-184

029396 Me Br Br z^'-Pr H 235-236

029497 Me Br Br Me Me 242-243

0295"See Index Table C for 1]Ξ NMR data L. J-NDEX TABLE B

0296<img file="EP1599463A1_D0042.tif" />

0297Compound Rl R² R3 R⁴_R5 R⁶ R7 m.p. PC)

029898 Me Br. Cl Me H H Cl 145-146

029999 Me Br Cl Et H H Cl 148-149

0300100 Me. Br Cl z^'-Pr H H Cl 174-175

0301101 Me Cl Cl Et H H Cl 167-168

0302102 Me Cl Cl z^'-Pr H H Cl 189-190

0303103 Me Cl Cl Me H H Cl 185-186

0304104 Me Br Cl Me H F H 152-153

0305105 Me Br Cl z^'-Pr H F H 134-136

0306106 Me Cl F H ^' H H F 212-213

0307107 Me Cl F Me H H F 214-215

0308108 Me Br F H H H F 204-205

0309109 Me Br F Me H H F 222-223

0310110 Me Br F Et - . H H F 200-201

0311111 Me Br F z^'-Pr H H F 203-204

0312112 Me Cl F Et H H F 195-196

0313INDEX TABLE C Cmpd No. 1_H R _Data (CDC1₃ solution unless indicated otherwise)

03143 (CDC1₃) 10.55 (s, IH), 8.45 (d, IH), 7.85 (dd, IH), 7.55 (s, 2H), 7.40 (dd,

0315IH), 6.97 (s, IH), 6.30 (b q,.lH), 2.98 (d, 3H), 2.24 (s, 3H)

03165 (CDC1₃) 10.55 (s, IH), 8.45 (d, IH), 7.85 (dd, IH), 7.57 (m, 2H), 7.37

0317(dd, IH), 7.05 (s, IH), 6.30 (b q, IH) 2.98 (d, 3H), 2.24 (s, 3H)

0318(CDC1₃) 10.10 (br s, IH), 8.38 (d, IH), 7.75 (s, IH), 7.65 (s, IH), 7.60 (m,

031918

0320IH), 7.34 (m, IH), 7.10 (s, IH), 6.58 (b q, IH) 2.96 (s, 3H)

032124 (CDC1₃) 10.12 (s, IH), 8.56 (d, IH), 7.85 (d, IH), 7.58 (m, 2H), 7.40 (dd,

0322IH), 6.97 (s, IH), 6.00 (b d, IH) 4.22 (m, IH), 2.25 (s, 3H), 1.26 (d, 6H)

032325 (CDC1₃) 10.60 (s, IH), 8.47 (d, IH), 7.85 (dd, IH), 7.56 (s, 2H), 7.39 (dd,

0324IH), 7.06 (s, IH), 6.04 (b d, IH) 4.20 (m, IH), 2.24 (s, 3H), 1.26 (s, 6H) Cmpd No. 1_H -J ΓMR _Data (CDC1₃ solution unless indicated otherwise)

0325^~ (CDC1₃) 10.60 (s, IH), 8.45 (d, IH), 7.85 (d, IH), 7.58 (s, 2H), 7.39 (m,

0326IH), 6.97 (s, IH), 6.20 (b t, IH) 3.46 (m, 2H), 2.25 (s, 3H), 1.25 (t, 3H) ₃₅ (CDC1₃) 10.60 (s, IH), 8.46 (d, IH), 7.85 (d, IH), 7.57 (s, 2H), 7.38 (m,

0327IH), 7.05 (s, IH), 6.25 (b t, IH) 3.46 (m, 2H), 2.24 (s, 3H), 1.25 (t, 3H) ₄₁ (CDC1₃) 10.40 (s, IH), 8.47 (d, IH), 7.85 (d, IH), 7.50 (s, 2H), 7.37 (dd,

0328IH), 6.63 (s, IH), 5.97 (s, IH) 4.68 (q, 2H), 1.42 (s, 9H)

BIOLOGICAL EXAMPLES OF THE TNNENTION

0330TEST A For evaluating control of diamondback moth (Plutella xylostella) the test unit consisted of a small open container with a 12-14-day-old radish plant inside. This was pre-infested with 10-15 neonate larvae on a piece of insect diet by use of a core sampler to remove a plug from a sheet of hardened insect diet having many larvae growing on it and transfer the plug containing larvae and diet to the test unit. The larvae moved onto the test plant as the diet plug dried out.

0331Test compounds were formulated using a solution containing 10% acetone, 90% water and 300 ppm X-77® Spreader Lo-Foam Formula non-ionic surfactant containing alkylarylpolyoxyethylene, free fatty acids, glycols and isopropanol (Loveland Industries, Inc. Greeley, Colorado, USA). The formulated compounds were applied in 1 mL of liquid through a SUJ2 atomizer nozzle with 1/8 JJ custom body (Spraying Systems Co. Wheaton, Illinois, USA) positioned 1.27 cm (0.5 inches) above the top of each test unit. All experimental compounds in these tests were sprayed at 50 ppm replicated three times. After spraying ofthe formulated test compound, each test unit was allowed to dry for 1 hour and then a black, screened cap was placed on top. The test units were held for 6 days in a growth chamber at 25 °C and 70% relative humidity. Plant feeding damage was then visually assessed based on foliage consumed.

0332Ofthe compounds tested the following provided very good to excellent levels of plant protection (20% or less feeding damage): 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 88, 89, 90, 91, 92, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 106, 108, 109, 110, 111 and 112.

0333TEST B For evaluating confrol of fall armyworm (Spodoptera frugiperda) the test xrnit consisted of a small open container with a 4-5-day-old corn (maize) plant inside. This was pre-infested (using a core sampler) with 10-15 1 -day-old larvae on a piece of insect diet. Test compounds were formulated and sprayed at 50 ppm as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test A.

0334Ofthe compounds tested, the following provided excellent levels of plant protection (20% or less feeding damage): 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 63, 64, 65, 66, 67, 68, 70, 73, 74, 76, 78, 88, 91, 92, 94, 95, 96, 98, 99, 100, 101, 102, 103, 106, 109, 110, 111 and 112.

0335TEST C For evaluating confrol of green peach aphid (Myzus persicae) through contact and or systemic means, the test unit consisted of a small open container with a 12-15-day-old radish plant inside. This^' was pre-infested by placing on a leaf of the test plant 30-40 aphids on a piece of leaf excised from a culture plant (cut-leaf method). The larvae moved onto the test plant as the leaf piece desiccated. After pre-infestation, the soil ofthe test unit was . covered with a layer of sand.

0336Test compounds were formulated using a solution containing 10% acetone, 90% water and 300 ppm X-77® Spreader Lo-Foam Formula non-ionic surfactant containing alkylarylpolyoxyethylene, free fatty acids, glycols and isopropanol (Loveland Industries, Inc.). The formulated compounds were applied in 1 mL of liquid through a SUJ2 atomizer nozzle with 1/8 JJ custom body (Spraying Systems Co.) positioned 1.27 cm (0.5 inches) above the top of each test unit. All experimental compounds in this screen were sprayed at 250 ppm, replicated three times. After spraying ofthe' formulated test compound, each test unit was allowed to dry for 1 hour and then a black, screened cap was placed on top. The test units were held for 6 days in a growth chamber at 19-21 °C and 50-70% relative humidity. Each test unit was then visually assessed for insect mortality.

0337Ofthe compounds tested, the following resulted in at least 80% mortality: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 40, 41, 43, 44, 46, 47, 48, 49, 50, 51, 52, 53, 55, 56, 63, 65, 66, 67, 68, 69, 70, 73, 74, 76, 78, 88, 89, 90, 91, 92, 94, 95, 96, 98, 99, 100, 101, 102, 103, 106, 108, 109, 110, 111 and 112.

0338TEST D For evaluating control of potato leafhopper (Empoasca fabae Harris) through contact and/or systemic means, the test unit consisted of a small open container with a 5-6 day old Longio bean plant (primary leaves emerged) inside. White sand was added to the top ofthe soil and one ofthe primary leaves was excised prior to appHcation. Test compounds were formulated and sprayed at 250 ppm and replicated three times as described for Test C. After spraying, the test irnits were allowed to dry for 1 hour before they were post-infested with 5 potato leafhoppers (18 to 21 day old adults). A black, screened cap was placed on the top ofthe cylinder. The test units were held for 6 days in a growth chamber at 19-21 °C and

033950-70%) relative humidity. Each test unit was then visually assessed for insect mortality.

0340Ofthe compounds tested, the following resulted in at least 80% mortality: 1, 3, 4, 5, 6, 8, 10, 12, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 32, 33, 34, 35, 37, 38, 40, 41,

034143, 44, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 63, 66, 67, 68, 70, 73, 76, 88, 89, 90, 94, 95,

034298, 99, 101, 103, 106, 108, 109, 110, 111 and 112. ^'

TEST E

0344For evaluating confrol of cotton melon aphid (Aphis gossypii) through contact and/or systemic means, the test unit consisted of a small open container with a 6-7-day-old cotton plant inside. This was pre-infested with 30-40 insects on a piece of leaf according to the cut-leaf method described for Test C, and the soil ofthe test unit was covered with a layer of sand.

0345Test compounds were formulated and sprayed at 250 ppm as described for Test D. The applications were repHcated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test D.

0346Ofthe compounds tested, the following resulted in at least 80% mortality: 1, 2, 3, 4, 5,

03476, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, 32, 33, 34,

034835, 36, 37, 38, 39, 40, 41, 42, 43, 44, 46, 47, 48, 49, 50, 51, 52, 53, 55, 56, 63, 69, 71, 72, 74, 76, 78, 79, 81, 84, 88, 89, 90, 91, 92, 95, 96, 97, 98, 99, 100, 101, 102, 103, 106, 108, 109,

0349110, 111 and 112.

TEST F

0351For evaluating confrol of corn planthopper (Peregrinus maidis) through contact and/or systemic means, the test unit consisted of a small open container with a 3-4 day old corn (maize) plant (spike) inside. White sand was added to the top ofthe soil prior to application.

0352Test compounds were formulated and sprayed at 250 ppm and replicated three times as described for Test C. After spraying, the test units were allowed to dry for 1 hour before they were post-infested with 10-20 corn planthoppers (18- to 20-day old nymphs) by sprinkling them onto the sand with a salt shaker. A black, screened cap was placed on the top ofthe cylinder. The test units were held for 6 days in a growth chamber at 19-21 °C and

035350-70% relative humidity. Each test unit was then visually assessed for insect mortality.

0354Ofthe compounds tested, the following resulted in at least 80% mortality: 1, 2, 3, 4, 5,

03556, 7, 8, 10, 11, 12, 13, 18, 20, 24, 25, 26, 27, 28, 29, 32, 33, 35, 37, 38, 39, 40, 41, 43, 45, 46,

035647, 48, 49, 50, 51, 53, 56, 88, 89, 90, 91, 94, 95, 108 and 109. TEST G

0357For evaluating confrol of silverleaf whitefly (Bemisia tabaci), the test unit consisted of a 14-21-day-old cotton plant grown in Redi-earth®^' media (Scotts Co.) with at least two true leaves infested with 2nd and 3rd instar nymphs on the underside ofthe leaves. Test compounds were formulated in no more than 2 mL of acetone and then diluted with water to 25-30 mL. The formulated compounds were applied using a flat fan air- assisted nozzle (Spraying Systems 122440) at 10 psi (69 kPa). Plants were sprayed to runoff on a turntable sprayer. All experimental compounds in this screen were sprayed at 250 ppm and repHcated three times. After spraying ofthe test compound, the test units were held for 6 days in a growth chamber at 50-60% relative humidity and 28 °C daytime and 24 °C nighttime temperature. Then the leaves were removed and the dead and live nymphs were counted to calculate percent mortahty.

0358Ofthe compounds tested, the following resulted in at least 80% mortality: 2, 3, 4, 5, 7, 8, 9, 10, 24, 25, 26, 27, 28, 30, 32, 33, 34, 35, 38, 41, 46, 48, 49, 51, 52, 53, 66, 67, 70, 73, 88, 92 and 98.

0359TEST H For evaluating movement of compounds in plants and control of green peach aphid (Myzus persicae) and potato leafhopper (Empoasca fabae) after foliar movement of compound through the plant, the test unit consisted of a small open container with a 12-15- day-old radish plant (for green peach aphid test) or 5-6 day old Longio bean plant (for potato leafhopper test).

0360Test compounds were formulated using a solution containing 10% acetone, 90% water and 600 ppm X-77® Spreader Lo-Foam Formula non-ionic surfactant containing alkylarylpolyoxyethylene, free fatty acids, glycols and isopropanol (Loveland Industries, Inc.). The formulated compounds were appHed in 20 micro Hters by pipet to two larger photosynthetically active leaves. All experimental compounds in this screen were apptied at 1000 ppm, and the tests were repHcated three times. After applying the formulated test compounds, the soil of each test unit was covered with a layer of sand and each test unit was allowed to dry for 1 hr and then a black, screened cap was placed on top. The test units were held in a growth chamber at about 20 °C and 50-70% relative humidity.

0361After 2 days, the treated leaves were covered on all sides with a fine plastic mesh, but with the leaf petiole intact and still attached to the plant to allow normal vascular movement and photosynthesis. The plants were then infested with 20-30 aphids (radish) or 20 leaflioppers (bean) and held in the growth chamber for 8 additional days. Each test unit was then visually assessed for mortaHty ofthe insects, which Had contacted and fed on the untreated plant tissues.

0362Results of green peach aphid mortality (% GPA M) and potato leafhopper mortality , (% PLH M) are Hsted in Table A. TABLE A

0363Percent Insect Mortality

0364Compound % PLH M % GPA M

03651 58 87

03663 96 81

03674 93 78

03685 96 94

03696 77 100

037026 73 67

037127 13 57

0372TEST I For evaluating movement of compounds in plants and confrol of green peach aphid

0373(Myzus persicae) and potato leafhopper (Empoasca fabae) after xylem movement of compound from soil application up through roots into foliage, the test unit consisted of a small open container with a 12-15-day-old radish plant (for green peach aphid test) or 5-6- day-old Longio bean plant (for potato leafhopper test). Test compounds were formulated using a solution containing 10% acetone, 90% water and 600 ppm X-77® Spreader Lo-Foam Formula non-ionic surfactant containing alkylarylpolyoxyethylene, free fatty acids, glycols and isopropanol (Loveland Industries, Inc.). The formulated compounds were applied ^' in 1 mL of solution by pipet to the soil at the base ofthe plant. All experimental compounds in this screen were applied at 1000 ppm, and the tests were replicated three times. After applying the formulated test compounds, each test unit was allowed to dry for 1 h. The soil of each test unit was covered with a layer of sand and then a black, screened cap was placed on top. The test units were held in a growth chamber at about 20 °C and 50-70% relative hvtmidity.

0374After 2 days, the plants were then infested with 20-30 aphids (radish) or 20 leafhoppers (bean) and held in the growth chamber for 5 additional days. Each test unit was then visually assessed for mortahty ofthe insects, which had contacted and fed on the untreated plant foliage.

0375Results of green peach aphid mortality (% GPA M) and potato leafhopper mortality (% PLH M) are Hsted in Table B. TABLE B

0376Percent Insect MortaHty

0377<img file="EP1599463A1_D0043.tif" />

03781 100 64

03792 56 64

03805 95 40

03816 100 59