EP1589013A3

Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations

Abstract

The object of the present invention is to find or provide pharmacologically active substances which are suitable for the prophylaxis and / or treatment of a wide variety of diseases, in particular disorders of the cardiovascular system (cardiovascular diseases), and which preferably act as adenosine receptor-selective ligands. The present invention relates to compounds of the formula (I) whereinR1 and R2are bonded to adjacent phenyl ring atoms and together with the two ring carbon atoms form a 5- to 7-membered saturated or partially unsaturated ring,R3(C1-C8th) -Alkyl, (C1-C8th) -Alkoxy, (C6-C10) -Aryl, hydrogen, hydroxy, halogen, nitro, cyano or -NH-C (O) -R5 meansR4(C2-C4) Alkenyl, (C3-C7) -Cycloalkyl or (C1-C8th) -Alkyl,R5(C1-C8th) -Alkyl, (C3-C7) -Cycloalkyl or (C6-C10) Aryl.

EP1589013A3, drawing sheet 1 — Sheet 1 of 1

Term

Term ended

Projected expiry passed 19 March 2022, 4.5 years ago.

Parties

Owner: BAYER SCHERING PHARMA AG
Assigned now: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Applicants: Bayer Health Care Aktiengesellschaft
Inventors: Rosentreter, Ulrich, Dr., 42349 Wuppertal, Germany
Krämer, Thomas, Dr., 42111 Wuppertal, Germany
Vaupel, Andrea, Dr., 04125 Riehen, Switzerland
Hübsch, Walter, Dr., 42113 Wuppertal, Germany
and 5 more inventorsShow fewer
Diedrichs, Nicole, Dr., 42553 Velbert, Germany
Krahn, Thomas, Dr., 58135 Hagen, Germany
Dembowsky, Klaus, Dr., 81249 München, Germany
Stasch, Johannes-Peter, Dr., 42651 Solingen, Germany
Shimada, Mitsuyuki, Nara 630-8323, Japan

Reach

Cites: 8 earlier patents, 1 other work⁠
Family: 13 members in 6 offices⁠EP4CA2DE2JP2US2WO

Classification

CPC: C07D405/04A61P1/16A61P3/10A61P9/00A61P11/00A61P13/00+7 more
IPC: C07D401 04A61K31 443A61K31 4433A61P1 16A61P3 10A61P9 00+11 more

1 sheet

Sheet 1

Every citation, both waysCites: the store holds 7 of 8

Citations
Document	Relation	Office	Category	Cited during	Relevant claims
WO0125210A2	Cites	World Intellectual Property Organization (WIPO)	PX	Search report	1-12
WO0162233A2	Cites	World Intellectual Property Organization (WIPO)	PX	Search report	1-12
WO0206237A1	Cites	World Intellectual Property Organization (WIPO)	PX	Search report	1-12
EP0285267A2	Cites	European Patent Office (EPO)	A	Search report	1-5,7,8,12
EP0908458A1	Cites	European Patent Office (EPO)	A	Search report	1-5,7,8,11
WO9412493A1	Cites	World Intellectual Property Organization (WIPO)	A	Search report	1-5,7,8,11
WO9916766A1	Cites	World Intellectual Property Organization (WIPO)	A	Search report	1-5,7-9,11,12
KANDEEL, EZ-EL-DIN M. ET AL.: "The use of activated double bond systems in heterocyclic syntheses", HETEROCYCLIC COMMUNICATIONS, vol. 3, no. 4, 1997, pages 371 - 380, XP001098754	Non-patent	–	–	Search report	–

13 members in 6 offices

This recordMember, by publication datePriority claim

Priority claims9

Priority claims
Document	Office	Kind	Date
10115922	Germany	A	2001-03-30
10115922	Germany	A	2001-03-30
10115922	Germany	–	2001-03-30
02732498	European Patent Office (EPO)	A	2002-03-19
02732498	European Patent Office (EPO)	A	2002-03-19
02732498	–	–	–
10115922	–	–	–
DE2001115922	–	–	–
EP20020732498	–	–	–

Members13

Family members, oldest first
Document	Office	Kind
CA2442256A1	Canada	A1	2002-10-10
DE10115922A1	Germany	A1	2002-10-10
WO02079195A1	World Intellectual Property Organization (WIPO)	A1	2002-10-10
EP1377569A1	European Patent Office (EPO)	A1	2004-01-07
US2004102626A1	United States of America	A1	2004-05-27
JP2004523592A	Japan	A	2004-08-05
EP1589013A2	European Patent Office (EPO)	A2	2005-10-26
EP1377569B1	European Patent Office (EPO)	B1	2005-11-02
EP1589013A3This record	European Patent Office (EPO)	A3	2005-11-09
DE50204779D1	Germany	D1	2005-12-08
US7078417B2	United States of America	B2	2006-07-18
JP4460835B2	Japan	B2	2010-05-12
CA2442256C	Canada	C	2010-06-15

12 legal events, as the office reported them to INPADOC

Over the term

Point at a mark for the event

Events

Legal events, newest first
	Event	Code
2012-03-28	Application deemed to be withdrawnWithdrawn18D	18D
2012-02-24	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWNSTAA	STAA
2011-08-24	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1
2009-09-16	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1
2009-09-09	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1
2006-07-12	Designation fees paidAKX	AKX
2006-06-21	Request for examination filed17P	17P
2005-11-09	Designated contracting statesAK	AK
2005-10-26	Divisional application: reference to earlier applicationAC	AC
2005-10-26	Designated contracting statesAK	AK
2005-09-23	Search report despatchedORIGINAL CODE: 0009013PUAL	PUAL
2005-09-09	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI