Agent containing fat (oil) which contains onion extract, the production and use thereof

0001The present invention relates to a novel fat (oil) containing compositions comprising Onion extract, as well as its preparation and its use for the care, Prevention or treatment of damaged skin tissue, such as by Operations, biopsies, cuts, burns and other accidents, and in particular of scars, stretch marks, degenerative Lesions u.ä .. The agent is characterized that there is a comprising base oil and inasmuch as in cream, lotion, fluid, massage oil or Balsam basis can be prepared. Therefore, it is fat (oil) sustainably .. Surprisingly, it was the onion extract, which in particular water, Alcohol or water-alcohol - sustainably is, in such an oleaginous base be built without its effectiveness is compromised or Phase separation occurs. Efficacy has been in medical Surveillances be detected.

0002Agents for treating damaged skin tissue, in particular scarred are known. In particular, this gel-like products are used. The US - A - 5,885,581 describes such a gel-like product, which 20 - 30 Percent by weight polyethylene glycol 200 0.005 0.03 percent by weight Preservatives, 0.05 0.2 weight percent sorbic acid, 0.5 2

0003Weight percent allantoin, 1- 3 percent by weight of xanthan gum and optionally Perfumes comprises and which is characterized by 5- 15 Weight percent of a liquid onion extract (extract Allium cepa), on the Based on an aqueous carrier in an amount of about 55- 65 weight percent. The product thus represents a fat (oil) - is free gel and is used externally on skin tissue, especially tissue vemarbtes applied. The Product is further characterized by a pH of 5.5 and a 4,5- Particle size of less than 50 microns.

0004In addition, a special plaster against scars is known which, under the Name "Hansaplast® scar reduction" without active ingredients to better to lead healing damaged skin. Here are appropriate Pflasterpads set approximately 8- 10 weeks the skin and promote increased by the Temperature level supposedly the regeneration process.

0005Under the product Kelofibrase® scar cream is known which as Agents urea and heparin sodium (60 000 IU) and camphor next contains customary oil / emulsifier components. This product is intended to Scar treatment, be used for scar contractures and keloids. Here, heparin sodium is known to act as a blood-thinning agent.

0006Under the name Hirudoid®forte a gel is known which as an active ingredient Mucopolysaccharide polysulfuric esters (445mg, according to 40 000 includes units in 100g ointment). Other ingredients are for Gel preparation necessary components such as isopropyl alcohol, polyacrylic acid, Propylene glycol and water. have Mucopolysaccharide polysulfuric esters generally a heparinoid effect and therefore correspond to the previously said Kelofibrase® product. In addition to the gel is also a Hirudoid®forte known ointment addition to the active top known a mixture of Mono- and di-glycerides of higher fatty acids and medium-chain triglycerides, etc. and isopropyl alcohol, imide urea, phenoxyethanol and water exhibits. Such products are applicable in the treatment of phlebopathies, superficial phlebitis, hematoma and for loosening hard Scar. The product may not be applied to broken skin.

0007Under the name Hylaform® a gel implant is known which contains cross-linked hyaluronic acid containing sodium chloride in an aqueous is solution available for the purpose of injection. With such means should Skin deformations be treatable. Acute or chronic skin diseases However, affected correction area must not be present.

0008Under the name Linoladiol® N a hydrophilic O / W cream is known, which contains estradiol as the active ingredient in the cream base. By means of this hormone-containing preparation, as well as gynecological applications dermatological applications, such as burns, scar treatment, Skin atrophy, perioral dermatitis and eczema in acute and subacute Stadium specified. Here, however, the hormone-containing products known restrictions on use as side effects or Interactions significantly observed.

0009Under the product name PC 30 V a Liquidum is described which Horse chestnut seed and chamomile flowers dry extract in 1,3-butanediol, contains panthenol, allantoin and odor substances. This product is intended to be useful in the treatment of skin damage such as chafing sensitive pressure points and scars by orthopedic apparatuses, and Bedsores. An indication regarding scars of operations or other Skin damage is not stated here.

0010The ointment Striatridin® contains the ointment base as an active substance alkyl-branched fatty acid esters of octadecyl alcohol, and Aminosäuresol Ethyl nicotinate. This product is useful for scar treatment, Stretch marks and for loose, functionally impaired skin usable.

0011The DE-A 196 28 284 describes the use of bear's garlic for the treatment of Psoriasis.

0012The DE-A 37 23 248 relates to the use of the thiosulfinic acid Treatment of inflammation. This may, inter alia, by the extraction of Onions and subsequent chromatography can be obtained. onion extract itself is not used here.

0013EP-B 429 080 relates to a manufacturing process for S-allylcysteine ​​containing Products, where z. B. aqueous garlic extracts are admixed with cysteine, whereby S-allylcysteine ​​arises.

0014EP-B 364 442 relates to an oil extract from at least 3 different herbs, chosen from euphorbia, veronica, yarrow, fumitory, garlic, nettle and marigold. This combination is an oil, eg with paraffin to Psoriasis applied.

0015EP-B EP 201 956 relates to the extraction and chromatographic fractionation for example, from tobacco, algae, garlic, wherein the obtained specific Substances are used as antioxidative substances in cosmetics should.

0016US-A 6,200,570 relates to compositions comprising garlic extract and at least one further plant extract, such as aloe vera and anti-inflammatory agents such as diclofenac with an antiallergic, analgesic effect.

0017JP-A 2000327535 describes a hair tonic which has, for example Allium having schoenoprasum and / or other plant extracts.

0018JP-A 09194334 relates to an effective hair loss hair tonic which z. B. having Allium sativum, and / or other plant extracts.

0019JP-A 08012570 and JP-A 0317413 relate to plant extracts such as Allium sativum or Allium victorialis containing anti- allergenic or anti-dandruff agents.

0020The abovementioned prior art shows that the for Scar treatment usable products are present either as a gel or, if they are not present as a gel, comprise active ingredients, which significantly can bring side effects. So the estradiol containing eg Product application is limited with regard to the hormone content. Mucopolysaccharide polysulfuric esters with their heparinoid effect can cause hypersensitivity reactions and may in no circumstances an injured skin are applied. The above-hyaluronic Hylaform® containing product is an implant for only mechanical correction of skin deformations and thus may be suitable itself brings no lasting effect on the skin tissue with it. The Liquidum PC 30 V is only minor bruising for scar treatment Scope, such as caused by orthopedic appliances, used and so far for permanent changing of damaged skin tissue by Surgery, injury, burns, etc. will not be described.

0021There is therefore a need for a product which is the above mentioned side effects not having. Furthermore, it should not be in gel form present as fat (oil) - free gels known to have a rather drying effect on may exercise the skin.

0022Object of the present invention is therefore to provide a product which having a well-tolerated drug and said in a is emulsion base incorporated, whereby the skin is not dried and, furthermore, a positive, caring, especially elasticity-promoting, skincare effect can be achieved.

0023This object is achieved by a means which as Drug has a onion extract and as the customary additives, chosen from consistency-imparting agents, dyes, antioxidants, perfumes, Humectants, preservatives, stabilizers, additional active ingredients, a Fat (oil) phase has.

0024Preferably an additional water phase and corresponding to Emulsifiers selected from the group consisting of O / W and / or W / O emulsifiers or mixtures thereof, or be contained with suitable co-emulsifiers.

0025The agents may total 5-99% fat (oil) phase, 0.1-35% additives, 1-20% Onion extract and the other substances, if any, in the bottom have stated amounts.

0026Particularly useful are agents which are composed of 70-99, very particularly 80-98% fat (oil) phase, 0.1-20%, in particular 0.1-10%, additives and 1-20%, preferably 1-10% and very particularly 2-5%, onion extract included, in which preferably the remainder may be solvent such. B. Alcohols (ethanol, isopropanol), for example in amounts of up to 20%.

0027The inventive agent is also preferably composed of a Fat (oil) phase in an amount of 5- 70%, 0.1 15% emulsifier (O / W; W / O); Or mixtures thereof with co-emulsifiers, 0.1- 35% additives, 1- 20% Onion extract and the residual water or a water / alcohol eg., Ethanol, Isopropanol, mixtures, for example to 20%.

0028In particular, as a fat (oil) phase 5-60%, preferably 5-40%, and particularly 5-25% suitable.

0029The onion extract is, in particular a water - or alcohol - or water-alcohol - Onion extract having.

0030With such a composition it is possible, surprisingly, the Onion extract as in a fat (oil) -containing phase such that in this case a uniform distribution of the extract is present stably and beyond means this basis, a desiccation of the treated skin can not take place and thus a care, elasticity-promoting effect is achieved so that the treatment of damaged skin parts both in terms of scarring influenced and slackening, and with regard to the skin softness positive or can be prevented.

0031Especially suitable in the present invention means between 1- 15%, 2-15%, in particular 5-15% of onion extract, based on the total amount, preferably 5 10, in particular 8 to 10% and very particularly preferably 2-4% or 10%.

0032The additives are preferably present 0.1 30, in particular 0.1-25%, depending on On the intended use.

0033The amount of emulsifiers is especially 0.1-10%, particularly 1-10%, preferably 1-8% and very particularly 1-5%.

0034The onion extract is, in particular an aqueous - ethanolic extract. He preferably comprises water and 10-15% ethanol.

0035It may also be advantageous to use an alcoholic onion extract. This, besides alcohol also preferably 10-80%, particularly 20-60% a solvent selected from triglycerides, hydrocarbons, and comprise fatty acid esters.

0036The amounts refer to% by weight unless otherwise indicated.

0037The fat (oil) phase is preferably selected from hydrocarbons, fatty alcohols, ethers and esters, olfettsäureestern (Poly), triglycerides, natural Oils, natural fats, waxes, silicone oils, silicone waxes or Mixtures thereof. In particular are liquid paraffins, lactic esters, Fatty alcohol ethers, evening primrose oil, silicone oil or mixtures thereof are preferred.

0038The W / O emulsifier advantageously has a HLB value of 1-9, in particular 1-8, preferably 2-7 and most preferably 3-6 and O / W emulsifier has an HLB value of 9-18, preferably 9-15 and in particular 9-13, or is an ionic O / W emulsifier.

0039As W / O emulsifiers are particularly preferred sorbitan derivatives, Polyethoxylated fatty acids / alcohols / esters / triglycerides, (poly) glyceryl derivatives, Polyol esters, glucose derivatives, pentaerythritol derivatives, alkylphenols, (Block) polymers, fatty acid salts, siloxanes or mixtures thereof, and very particularly among Abil.RTM EM 90, Arlacel ®582 and magnesium stearate or mixtures thereof having.

0040There may also be co-emulsifiers available, such as Arlatone®T (V) here.

0041When O / W emulsifiers are in particular polyoxyethylated products, nonionic and ionic phosphates, ionic monovalent salts, (Poly) glyceryl esters, sugar esters, sterol derivatives, castor oil derivatives, siloxanes thereof or mixtures thereof or mixtures with coemulsifiers thereof. Particularly suitable here are Tego Care® 450, Eumulgin ®B1 or mixtures Suitable thereof and / or with co-emulsifiers.

0042Are very particularly preferred in the presence of O / W emulsifiers Stabilizers selected from acrylamides, acrylates and polysaccharides, in particular those such as are described below.

0043It is furthermore preferred if the agents according to the invention continues as Additives, those selected from vitamins, electrolytes such. B. Magnesium sulfate or sodium chloride, allantoin, D-panthenol, hyaluronic acid, Mucopolysaccharides, dyes, perfume substances, preservatives, comprise humectants.

0044In particular, in addition wax products and or alternatively, as a Additive further Lecitine, especially Phosal®50 SA be included.

0045The agent may be different amounts of water, fat phase, emulsifier, Additives and active ingredient (onion extract) included. Here, then, depending on the intended application, for example, a lotion, a fluid cream, or a get balsam / ointment.

0046The agent can be therefore composed preferably of a fat (oil) phase in an amount of 5-70% by weight, in particular 5-55%, one or more W / O emulsifiers, mixtures thereof or with coemulsifiers in a total amount of 0.5- 15%, particularly 0.5-10%, and 0.1- 25%, in particular from 0.1 to 22%, of additives of the type mentioned above, as well as 1- 15, in particular 1-10% of the abovementioned onion extract and water as the remainder or a mixture of water with alcohols such as ethanol, isopropanol in Amounts up to 20%.

0047The agent may be particularly composed of 5- 40% in particular 5-30% fat (oil) phase, 0.1- 15%, in particular 1-10% of one or more O / W emulsifiers or mixtures thereof or with coemulsifiers, 0.1- 32%, in particular 0.1-20% additives, and 1- 10% Onion extract and the balance water or a mixture of water with alcohols such as ethanol, isopropanol in amounts up to 20%.

0048In this way, the agent may for the treatment of scars or of damaged and / or slackened skin tissue especially as eg Massage oil or balsam, lotion, fluid or cream are produced. So can when using W / O emulsifiers in particular lotions, and a Balsam and with the use of O / W or W / O emulsifiers in particular creamy products or fluid occur. Depending on the application area are selected between these products. Particularly suitable is a O / W cream of the type described above for the treatment of acne scars, for example. If larger areas are treated, a lotion is recommended that preferably in the treatment or for the prophylactic prevention of is stretch marks or generally slackened skin used. Also larger surface use is a balm, the most for suitable treatment of operation scars or burn scars, cuts is. Massage oil is particularly suitable for the prevention or care and Treatment of larger areas of skin such as for stretch marks.

0049However, the dosage form is not limited to a specific indication and can be varied.

0050The individual ingredients are described in more detail below:

<b>I. onion extract</b>

0051As onion extract is particularly suitable a water, alcohol or water-alcohol containing extract from dried onions. The extraction can Registered with water itself or else with alcohol, optionally with the addition of Solvents as mentioned below, or a mixture of water and one or more alcohols, as hereinafter made, will. The dried onions, also known as dried onion chips, obtained from the stock plant Allium cepa Linne, can initially with extracting the extraction agent, preferably by the drug in the heat, for example at 40-90 ° C, exhaustively percolated. The percolate can then when appropriate, in particular, an elevated temperature above 30 ° C under vacuum to Spissum extract (thickened extract) evaporated and then the desired solvent to water, alcohol or water-alcohol mixture - Fluid extract are dissolved. Alternatively, the fluid extract even without prior evaporation by direct reaction with the desired solvent can be obtained.

0052This gives a reddish-brown to brown liquid with a characteristic Odor. The ratio of dry drug to fluid extract can vary from 0.1: 1 to 10: 1, preferably 0.1: 1 to 5: 1, in particular 0.15 1 to 4: 1. All particularly preferred ratios are 0.16: 1 or 4: 1.

0053Particularly preferred are fluid extracts of the type mentioned with water / alcohol mixture or only alcohol as solvent. In mixture is preferably 5-60%, in particular 10-50% and especially 10-40% or 10-15, especially 13%, alcohol, preferably ethanol, included.

0054The alcohol is preferably selected from ethanol, isopropanol or propanol or dihydric alcohols such as butylene glycol, propylene glycol or mixtures . thereof Particularly preferred is ethanol.

0055It may be furthermore advantageous if the onion extract containing water or other such as the alcoholic solvents mentioned above is extracted, the alcoholic fluid extract as described, worked becomes. In particular, this can 10-80%, preferably 20-60% of the alcohol by a solvent selected from the following point II said substances, especially hydrocarbons, triglycerides, particularly are medium chain, and fatty acid esters or mixtures thereof, is replaced.

0056An inventively usable onion extract can, for example, as follows getting produced:<sl><li>The dried onions, also called onion chips, for example, can purified water, for example in the ratio of drug to extractant (water) of extract 1:16. The ratio of dry drug to native extract then corresponds to 1.8: 1, or 1.5-2.2:. 1 The ratio of dry drug to Fluid extract is then 0.16:. 1 The drug (eg 16 kg of chips) is with hot water (80- 90 degrees Celsius) percolated to completion. The percolate can then at about 55 Degrees Celsius under vacuum to spissum extract (thickened extract) be evaporated. In this flash-pasteurized (eg 3 seconds at 141 degrees Celsius). The spissum extract obtained is viscous and is in water, Alcohol or water-alcohol mixture to the fluid extract eg of the abovementioned ratio dissolved. This gives a reddish brown to brown liquid characteristic odor. This extract is with water in any ratio miscible, has a relative density at 20 degrees Celsius of 1,00- 1,03 g / ml. If water / alcohol, in particular ethanol was worked, as can about 13- 20% present (V / V) alcohol (eg ethanol). The dry residue (After 2 hours at 105 degrees Celsius) is at least 7.0% (m / m). With regard to the microbiological purity, the product corresponds to Requirements of category 3 of the DAB 10th</li><li>The characteristic ingredients of the onions are derivatives of sulfur-containing amino acids. Besides are protein, fat and Carbohydrates before.</li></sl>

0057The product manufactured as described above is for example obtainable from Fa. Finzelberg extracts and described in the abovementioned US Pat 5,885,581th

0058This extract as described above is used in the scar gel according to the US Patent 5885581 used. In contrast to the gel composition However, it was surprisingly, this extract into an oil-based or oil-water-containing incorporate basis, while providing a complete and homogeneous distribution of active ingredients and in particular her remain intact remains assured, especially if the proportion of this extract phase, in particular in aqueous, alcoholic, aqueous / alcoholic form, is very high is.

0059therefore preferable to use a water- alcohol onion extract in the Inventive agents, in particular described a above Water-ethanol extract, preferably 10-40, in particular 13-20%, in particular 10-15% ethanol content.

0060As mentioned, the onion extract can, instead of ethanol, other solvents, in particular glycol, butylene glycol, propylene glycol have.

0061Also preferred is an alcohol, preferably ethanol-containing, extract, which in particular beyond as mentioned, another solvent, eg 10-80%, especially 20-60%, as having mentioned in point II can. Preference is given here hydrocarbons, triglycerides medium-z. B., Fatty acid esters.

0062Also suitable are mixtures of a water-alcohol, in particular ethanol-onion extract, eg with 10-40% ethanol as described above and a alcoholic, especially ethanolic onion extract with 10-80% in particular 20-60%, solvent as mentioned in point II, in particular here hydrocarbons, triglycerides medium-z. B., Fatty acid esters suitable. The ratio of water / alcohol and Alcohol / solvent onion extract can, in particular 3: 1 to 1: 3, preferably 1: 1.

<b>II.Fett (oil) phase</b>

0063For the fat (oil) phase of this conventional oil can be used components will. These include:<sl><li>Customary, preferably liquid, lipids, these may be used individually or in combination present.</li><li>In particular, the following groups and examples thereof are suitable:<sl><li><u>1.Kohlenwasserstoffe</u> Hydrocarbons such as squalene, squalane, in particular also liquid paraffins (Paraffinum Perliquidum), isoparaffins, Dioctylcyclohexane (Cetiol.RTM S) Isohexadecane (Arlamol® HD); </li><li><u>2.Fettalkohole</u> such as oleyl alcohol, octyldodecanol (Eutanol® G);</li><li><u>3.Fettsäureester,</u> eg Isopropylfettsäureester (palmitate, myristate, isostearate, Oleate), Decyl Oleate (Cetiol.RTM V), Hexyl Laurate, C 12-15 Alkyl Benzoate (Finsolv® TN), Dicaprylyl Carbonate (Cetiol CC), diesters such Dibutyladipate (Cetiol®B), propylene glycol Dipelargonate, branched fatty acid esters such PCLliquid® (Cetearyl octanoate) or mixtures such as Cetiol PGL (Hexyldecanol and Hexyldecyl Laurate);</li><li><u>4.Fettalkoholether</u> as Dicaprylyl Ether (Cetiol.RTM OE) or <u>Fatty alcohol esters</u> as Lactic acid esters such as C12-13 alkyl lactates (Cosmacol® ELI);</li><li><u>5.Polyolfettsäureester</u> as Cetiol.RTM HE (PEG-7 glyceryl cocoate);</li><li><u>6.Trictlyceride</u>, In particular medium (neutral oils), such as caprylic / capric Triglycerides (Miglyol® 810, 812) and their polyol esters such as Propylene Glycol Dicaprylate / dicaprate (Miglyol® 840);</li><li><u>7.Natürliche fats and oils</u> as sunflower, soy, peach seed, Apricot, grape seed oil, castor oil, peanut, almond, mink, wheat germ, Avocado oil, evening primrose oil;</li><li><u>8.Wachse,</u> such as natural liquid waxes such as jojoba oil or its substitute Oleyl erucate (Cetiol J 600) or synthetic waxes such as the following described under "bodying".</li><li><u>9.Silikonöle and waxes</u>, For example, polydimethylsiloxanes such as Dow Corning 200 Fluid® (Dimethicone), Cyclomethylsiloxane as Dow Corning 345 Fluid® (Cyclomethicones), phenylmethylpolysiloxanes as phenyl dimethicone (Abil.RTM AV 8853) or alkyl-polymethylsiloxane copolymers, such as cetyl dimethicone (Abil.RTM Wax 9801), stearyl dimethicone (Abil.RTM Wax 9800), dialkoxydimethylpolysiloxanes as Stearoxy Dimethicone (Abil.RTM Wax in 2434), Behenoxy Dimethicone (Abil.RTM Wax 2440)</li></sl></li></sl>

0064Particularly preferred oil components are liquid paraffins, fatty acid esters as isopropyl palmitate or myristate, alcohol ethers such as Dicaprylyl Ether (Cetiol®OE) and said natural fats and oils, in particular Avocado, soy, peach seed, apricot kernel oil and very particularly Evening primrose oil, in particular mixtures thereof, silicone oils type described above as well as lactic acid esters as well as Cosmacol® ELI Mixtures thereof with the abovementioned components.

0065Particularly preferred are said liquid paraffins, Lactic esters, fatty alcohol ethers, evening primrose oil and silicone oils, also in Combination with each other, about 1- 50%, based on single component the total amount of oil may be present.

0066Further, silicone waxes are particularly suitable, especially Combinations thereof and also with the abovementioned paraffins, Lactic acid esters and evening primrose oil.

<b>III.Emulgatoren</b>

<b>A). W / O emulsifiers</b>

0067As W / O emulsifier / s are those having a suitable HLB value of 1- 9, insbesondere1- 8. Particularly preferred are the following products:<sl><li><u>1.Sorbitan derivatives</u> Sorbitan esters such as sorbitan oleates (Span® 80, HLB = 4.5) Sorbitan Stearate (HLB = 5.0), sorbitan Sesquioleate (Crill® 43, HLB = 3.7), sorbitan isostearate (Crill® 6, HLB = 4.7), sorbitan tristearate (Crill® 35, HLB = 2.1); and Arlacel® 582 (Sorbitan Isostearate, PEG-2 Hydrogenated Castor Oil, Ozocerites, Hydrogenated Castor Oil, HLB = 5).</li><li><u>2.Polyethoxylierte products</u> Polyethoxylated fatty acids and alcohols such as PEG-2 oleate (HLB = 5.0), PEG-4 Distearates (HLB = 3.0), PEG-2 Stearate (HLB = 4.4), Ceteareth-3, (Volpo® CS3, HLB = 5.0), Ceteth-2 (Volpo® C2, HLB = 5.3); Polyoxyethylene fatty acid esters such Arlatone® T (V) (PEG-40 Sorbitan Peroleate, HLB = 9); Ethoxylated triglycerides such as PEG-5 castor oil (HLB = 3.9), PEG-6 Diricinoleate (HLB = 5.0), PEG-7 Hydrogenated Castor Oil (Cremophor® WO 7, HLB = 5.0);</li><li><u>3. (poly) glyceryldehyate</u> Polyglyceryl-3 diisostearate such as polyglyceryl (Lameform® TGI, HLB = 3.5), Polyglyceryl-2 Dipolyhydroxystearate (Dehymuls® PGPH, HLB = 3.5), Diisostearoyl Polyglyceryl-3 diisostearate (Isolan® PDI, HLB ca. 5), polyglyceryl-3 Oleate (Isolan® GO 33, HLB ca. 5), polyglyceryl-3 dioleate (Cremophor GO 32, HLB ca. 5), polyglyceryl-4 isostearate (Isolan® GI 34, HLB ca. 5); Glycerol esters such as glyceryl ricinoleate (Cithrol® GMR N / E, HLB = 2.7), glyceryl Laurate (Cithrol® GML N / E, HLB = 4.9), glyceryl dioleate S / E (Cithrol® GDO S / E, HLB = 2.9).</li><li><u>4.Polyolester</u> Polyol esters such as glycol oleate S / E (Cithrol® EGMO S / E, HLB = 2.7), glycol Ricinoleate (Cithrol® ECHR S / E, HLB = 2.0), Glycol Dilaurate S / E (Cithrol® EGDL S / E, HLB = 2.0), Propylene Glycol Ricinoleate (Cithrol® PG MR S / E, HLB = 3.6), Propylene glycol laurate (Cithrol® PGML N / E, HLB = 2.7);</li><li><u>5.Glucose derivatives</u> Glucose esters such as methyl glucose dioleate (Isolan® DO, HLB ca. 5), methyl Glucose Isostearate (Isolan® IS, HLB ca. 5);</li><li><u>6.Pentaerythrit derivatives</u> Pentaerythritol fatty acid esters, for example Pentraerythrityl monolaurates (HLB = 4.8), Pentaerythrityl Monotallate (HLB = 4.0) or mixed esters, for example with citric acid Fatty alcohol esters such Dehymuls® E (Dicocoyl pentaerythrityl distearyl citrate, Sorbitan Sesquioleate, Cera Alba, aluminum stearate, HLB = 4.0), F Dehymuls® (Dicocoyl pentaerythrityl distearyl citrate, Cera Microcristallina, Glyceryl Oleate, Aluminum Stearate, Propylene Glycol, HLB = 4.0);</li><li><u>7.Alkylphenole</u> eg nonoxynol-2 (HLB ca. 4.5);</li><li><u>8.Polymere</u> Polymers such as polyoxypropylene polyoxyethylene block polymers (INCI name: Poloxamers), for example Pluronic PE 3100 (HLB = 4.5), Pluronic®PE 6100 (HLB = 3.0) or PEG-30 Dipolyhydroxystearate (ArlacelR P 135, HLB ca. 5.5);</li><li><u>9.Siloxan derivatives</u> Polysiloxane copolymers such as polysiloxane-polyether copolymers, in particular Polysiloxane-polyalkyl-polyether copolymers, such as cetyl dimethicone copolyol (Abil.RTM EM 90, HLB = about 5), Laurylmethicone copolyol (Dow Corning® Q2-5200, HLB ca. 4) or mixtures thereof as Abil.RTM WE 09 (cetyl dimethicone copolyol Polyglyceryl-4-isostearate, hexyl laurate, HLB ca. 5). </li><li><u>10.Fettsäure salts</u> polyvalent salts such as magnesium, aluminum, or zinc stearate, wherein Magnesium stearate is preferred.</li></sl>

0068Particularly preferred emulsifiers are Abil ® EM 90 (cetyl dimethicone Copolyol) or Adacel ® 582 (Sorbitan Isostearate, PEG-2 Hydrogenated Castor Oil, ozokerite, hydrogenated castor oil, HLB = 5) or magnesium, Aluminum, zinc stearate, in particular mixtures thereof. Further, the combined emulsifiers mentioned with suitable coemulsifiers be, so that the desired HLB value is present. This includes eg Arlatone® T (V), in particular in combination with the preferred W / O emulsifiers.

<b>B) O / W emulsifiers</b>

0069When O / W emulsifiers are in particular those having an HLB value of 9- 18, preferably suitable 9- 15 and in particular 9- thirteenth

0070These preferably include polyoxyethylated products such as (HLB values ​​on the right):<tables><table><tgroup cols="3"><tbody><row><entry align="left">G - 2111</entry><entry align="left">polyoxyethylene oxypropylenoleat</entry><entry align="left">9.0</entry></row><row><entry align="left">G - 2125</entry><entry align="left">Tetrathylenglykolmonolaurat</entry><entry align="left">9.4</entry></row><row><entry align="left">Brij® 30</entry><entry align="left">polyoxyethylene</entry><entry align="left">9.5</entry></row><row><entry align="left">Tween 61</entry><entry align="left">polyoxyethylene</entry><entry align="left">9.6</entry></row><row><entry align="left">Tween 81</entry><entry align="left">polyoxyethylene</entry><entry align="left">10.0</entry></row><row><entry align="left">G - 3806</entry><entry align="left">polyoxyethylene</entry><entry align="left">10.3</entry></row><row><entry align="left">Tween 65</entry><entry align="left">polyoxyethylene sorbitan</entry><entry align="left">10.5</entry></row><row><entry align="left">Tween 85</entry><entry align="left">polyoxyethylene</entry><entry align="left">11.0</entry></row><row><entry align="left">G - 3910</entry><entry align="left">Polyoxyethylenoleyether</entry><entry align="left">12.2</entry></row><row><entry align="left">G - 2127</entry><entry align="left">polyoxyethylene monolaurate</entry><entry align="left">12.8</entry></row><row><entry align="left">Renex® 690</entry><entry align="left">polyoxyethylene alkylaryl</entry><entry align="left">13.0</entry></row><row><entry align="left" /><entry align="left">Polyethylene glycol 400 monolaurate</entry><entry align="left">13.1</entry></row><row><entry align="left">Cremophor® EL</entry><entry align="left">polyoxyethylene castor oil</entry><entry align="left">13.3</entry></row><row><entry align="left">G - 1284</entry><entry align="left">polyoxyethylene castor oil</entry><entry align="left">13.3</entry></row><row><entry align="left">Tween 21</entry><entry align="left">polyoxyethylene</entry><entry align="left">13.3 </entry></row><row><entry align="left">Renex® 20</entry><entry align="left">Polyoxyethylene mixed fat 'and resin acids</entry><entry align="left">13.5</entry></row><row><entry align="left">G - 1441</entry><entry align="left">Polyoxyethylene - lanolin</entry><entry align="left">14.0</entry></row><row><entry align="left">G - 7596J</entry><entry align="left">polyoxyethylene</entry><entry align="left">14.9</entry></row><row><entry align="left">Tween 60</entry><entry align="left">polyoxyethylene</entry><entry align="left">14.9</entry></row><row><entry align="left">Tween 80</entry><entry align="left">polyoxyethylene</entry><entry align="left">15.0</entry></row><row><entry align="left">Myrj.RTM 49</entry><entry align="left">polyoxyethylene</entry><entry align="left">15.0</entry></row><row><entry align="left">G - 3720</entry><entry align="left">polyoxyethylene</entry><entry align="left">15.3</entry></row><row><entry align="left">G - 3920</entry><entry align="left">Polyoxyethylenoleyether</entry><entry align="left">15.3</entry></row><row><entry align="left">Tween 40</entry><entry align="left">polyoxyethylene</entry><entry align="left">15.6</entry></row><row><entry align="left">G - 2162</entry><entry align="left">polyoxyethylene oxypropylenmonostearat</entry><entry align="left">15.7</entry></row><row><entry align="left">Cremophor® 0</entry><entry align="left">polyoxyethylene fatty alcohol ethers</entry><entry align="left">16.0</entry></row><row><entry align="left">G - 1471</entry><entry align="left">Polyoxyethylene - lanolin</entry><entry align="left">16.0</entry></row><row><entry align="left">Myrj.RTM 51</entry><entry align="left">polyoxyethylene monostearate</entry><entry align="left">16.0</entry></row><row><entry align="left">cetomacrogol 1000</entry><entry align="left">Polyoxyethylene glycol 1000 monocetyl ether</entry><entry align="left">16.1</entry></row><row><entry align="left">Tween 20</entry><entry align="left">polyoxyethylene</entry><entry align="left">16.7</entry></row><row><entry align="left">Brji® 35</entry><entry align="left">polyoxyethylene</entry><entry align="left">16.9</entry></row><row><entry align="left">Myrj.RTM 52</entry><entry align="left">polyoxyethylene monostearate</entry><entry align="left">16.9</entry></row><row><entry align="left">Myrj.RTM 53</entry><entry align="left">polyoxyethylene monostearate</entry><entry align="left">17.9</entry></row></tbody></tgroup></table></tables>

0071Further preferred are also:<tables><table><tgroup cols="3"><tbody><row><entry align="left">Myrj.RTM 45</entry><entry align="left">polyoxyethylene glycol monostearate</entry><entry align="left">11.2</entry></row><row><entry align="left" /><entry align="left">Polyoxyethylene glycol 400 monooleate</entry><entry align="left">11.4</entry></row><row><entry align="left">Cremophor® AP firmly</entry><entry align="left">Polyoxyethylenglykol- 400 monostearate</entry><entry align="left">11.6</entry></row><row><entry align="left">G - 2161</entry><entry align="left">Polyoxyethylenglykol400 monostearate</entry><entry align="left">11.6</entry></row><row><entry align="left">Brij 721 P</entry><entry align="left">Steareth-21</entry><entry align="left">15.5</entry></row><row><entry align="left">Eumulgin®B1</entry><entry align="left">Ceteareth-12</entry><entry align="left">13</entry></row></tbody></tgroup></table></tables>

0072Preference is also commercial mixtures with co-emulsifiers such as fatty alcohols or glyceryl esters as emulsifier E 2149 (steareth-7, Stearyl Alcohol, HLB = 11) or 165 ArlacelR FL (Glyceryl Stearate, PEG-100 Stearate, HLB = 11) or<tables><table><tgroup cols="3"><tbody><row><entry align="left">Atlox® 3300</entry><entry align="left">Alkylarylsulfonattriethanolamioleat</entry><entry align="left">11.7</entry></row></tbody></tgroup></table></tables>

0073Also preferred are nonionic and ionic phosphates, such as cetyl or Stearyl phosphates (HLB = 8, or 10), Trilaureth-4 Phosphate (Hostaphat® KL 340, HLB about 13), triceteareth-4 Phosphate (Hostaphat® KW 340, HLB = 10), (Poly) glyceryl ester as Dermofeel®Q 182 S (Polyglyceryl-10 distearate) or PEG-4 Polyglyceryl-2 Stearate (Hostacerin® DGSB, HLB ca. 8), Polyglyceryl-2 PEG-10 Laurate (Hostacerin® DGL, HLB about 14), Polyglyceryl-3 Methyl Glucose Distearate (Tego Care® 450, HLB = 12) or mixtures such Eumulgin.RTM VL 75 (Lauryl Glucoside, Polyglyceryl-2 Dipolyhydroxystearate, glycerol, HLB about 13). Also preferred sugar esters are as glucose esters eg Cetearyl Glucoside (Tego Care® CG 90, HLB = 11), Methyl Glucose Sesquistearate (Tego Care® PS, HLB = 12), PEG-20 Methyl Glucose Sesquistearate (Glucamate® SSE, HLB = 15) or mixtures with fatty alcohols such Montanov® 82 (Cetearyl Alcohol, Coco Glucoside, HLB = 11), Montano® 14 (myristyl alcohol, myristyl glucoside, HLB = 10), Montanov® 202 (arachidyl alcohol, behenyl alcohol, arachidyl Glucosides, HLB = 8) or sucrose esters such as sucrose stearate (Crodesta® F 160, HLB = 14.5), Sucrose Cocoate (Crodesta® SL 40, HLB = 15) or mixtures thereof, eg Crodesta® F 110 (Sucrose Stearate, Sucrose Distearate, HLB = 12).

0074Furthermore, sterol derivatives can be employed as emulsifiers, for example lanolin derivatives as Laneth-20 (Polychol® 20, HLB = 14) or Generol® RE 10 (PEG-10 Rapeseed Sterol, HLB = 12) or castor oil derivatives such as PEG-40 Hydrogenated Castor Oil (Eumulgin.RTM HRE 40, HLB = 15) or PEG-36 Castor Oil (Arlatone® 650, HLB = 12.5), or mixtures thereof as Arlatone® 980 (PEG-15 Hydroxystearate, PEG-25 Hydrogenated Castor Oil, HLB = 12.8).

0075It can also preferred siloxane derivatives, in particular polysiloxane-polyether copolymers as Abil.RTM Care 85 (dimethicone copolyol, caprylic / capric Triglycerides, HLB = 10) are used.

0076As ionic emulsifiers can here monovalent salts eg of fatty acids or be used fatty alcohol sulfates such as sodium or triethanolaminostearate, Lanette.RTM E (Sodium Cetearyl Sulfate) or phosphates, Amphisol® K (Potassium Cetyl Phosphate) or glutamates, for example Hostapon® CCG (Sodium Cocoyl Glutamate) or lactylates, eg Crolactil® SSL (Sodium Stearoyl lactylate).

0077All abovementioned emulsifiers can also in mixtures with co-emulsifiers, which also commonly referred to as <b>bodying</b> be used be able to be used. These may consist of the group of fatty alcohols such as Stearyl Alcohol (Lanette.RTM 18), Cetyl Alcohol (Lanette.RTM 16), Myristyl Alcohol (Lanette.RTM 14) or Cetearyl Alcohol (Lanette.RTM O) are selected. Further suitable are fatty acids, eg stearic acid or glyceryl esters such as Glyceryl stearate, in particular glycerol monostearate or glycerol or thereof mixtures, eg Tegin.RTM M.

0078Furthermore, as bodying agents and waxes are used, for example, Beeswax (Lunacera® alba), Kester®Wachs K82H (C_20-40- Alkyl stearate) or Lunacera® M (Micro Wax) or hydrocarbon waxes such Lunacera® P (Mineral Wax) and hydrogenated castor oil (Cutina.RTM HR) or synthetic Waxes such as cetyl palmitate (Cutina.RTM CP) or myristyl (Crodamol® MM) or stearyl stearate (Crodamol® SS).

0079Especially <u>preferred O / W emulsifiers</u> are:<sl><li>Tego Care® 450 (Polyglyceryl-3 Methyl Glucose Disterate, HLB = 12),</li><li>Eumulgin® B1 (ceteareth-12, HLB = 13), or mixtures thereof.</li></sl>

0080Also preferred are the above Hostaphat® products or Abil.RTM Care 85th

<b>IV.Zusatzstoffe</b>

<b>1) additional active ingredients</b>

0081As additional active ingredients may in particular vitamins such as tocopherol (Vitamin E) or vitamin A, for example, be chosen as retinol. Further, Electrolytes such as magnesium sulphate or sodium chloride (electrolyte for example in amounts suitably from 0.2- 2%). Further polysaccharides such as glycosamine glycans, in particular mucopolysaccharides are used. These include especially not heparinoid compounds such as chondroitin sulfate or Dermatan or keratan or else heparinoid compounds such as Heparin, in particular their salts, for example sodium salts.

0082Further, in particular, allantoin, D-panthenol, hyaluronic acid and / or Zinc derivatives such Zincidone® (zinc PCA), zinc gluconate or zinc oxide suitable.

0083The amounts of individual active ingredients vary and can, for example, each 0.01 20% respectively and 0.1% 6, in particular 1- 5% and 3- 5%, respectively.

0084Moreover, vesicle formers, in particular lecithins and analogs thereof Suitable additional active ingredients. These include, for example, known substances (cf.. DE 42 05 548 C 2), in particular phospholipids such as lecithin (egg or soybean lecithin) eg Phosal® 50 SA (about 50% soybean lecithin), phosphatidyl choline, serine or - diethanolamine and mixtures thereof.

0085Further suitable lecithin-analogous components are sphingolipids (eg Ceramides, cerebrosides, sphingosine, sphingomyelin), phytosterols (in essentially mixtures of β-sitosterol, campesterol and stigmasterol) and Derivatives thereof, in particular ethoxylates such as Generol® 122 E 5 (PEG-5 Soybean Sterol), Gererol® R E5 (PEG-5 Rapeseed Sterol).

0086Further suitable vesicle formers are polyethoxylated fatty alcohols and Fatty acids having preferably 1-4 EO with an HLB value of 2 to 6, where the lipophilic radical preferably consists of C₁₆ -C₁₈Alkyl chains is, Polyglycerolalkylether, Glucosyldialkylether, sucrose diesters, Kollagenhydrolysatester, quaternary ammonium compounds and poloxamers. Particularly preferred egg and / or soybean lecithin are (Phosal® 50SA) Phosphatidylcholine, ceramides, phytosterols and ethoxylated derivatives thereof with a degree of ethoxylation from 5 to 16 and polyoxyethylated fatty alcohols with thereof an HLB value of 2-6 or combinations, in particular of Phytosterols of the abovementioned type with ethoxylation products thereof.

0087Particular preference here is Phosal® 50 SA.

0088Particularly preferred additional active ingredients are:<sl><li>a) Vitamin E (eg, 0.1 5, in particular from 0.1 1%);</li><li>b) magnesium sulfate and / or sodium chloride (zB0,1-5, particularly 0.1 1%);</li><li>c) mucopolysaccharides such as chondroitin sulfate (zB0,1- 2, particularly 0.1-1%) and heparin or heparinoids like heparin-Na (zB0,1-2, especially 0.1-1%);</li><li>d) allantoin; Amounts as above; for example 0.05-2%, preferably 0.1-1%;</li><li>e) D-panthenol; Amounts as above; such as 0.1-10%, preferably 1-5%;</li><li>f) hyaluronic acid (zB0,001- 1, in particular 0.01- 0.1%);</li><li>g) as lecithins Phosal® 50 SA (zB0,5- 5%, in particular 1 2%);</li><li>h) zinc derivatives such as zinc gluconate or zinc PCA (Zincidone®), for example 0.1-3, in particular 0.5-1%</li><li>i) oil-absorbing substances, eg starch derivatives such Natrasorb® HFB (Aluminum starch, octenyl succinates, acrylates copolymer, magnesium Carbonate) or acrylates, eg Micropearl® M 100 (polymethyl methacrylate) Micropearl® M 305 Methyl Methacrylate Copolymer) or sulfonates such as Biopol.RTM OE (Sodium C8-16 Isoalkylsuccinyl lactoglobulin sulfonate).</li></sl>

0089Furthermore, astringent and sebum-regulating substances be used as Acnacidol® 101 (Propylene glycol, Hydroxydecanoic Acid), Asebiol® BT (Hydrolyzed Yeast Protein, Pyridoxine, Niacinamide, Glycerine, panthenol, propylene glycol, allantoin, biotin), Lipacide® C8C0 (Caproyl collagen Aminoacids) Sebosoft® (Glycerin, Aqua, PEG-8, Caprylyl Glycol, Sebacic Acid, Sodium Polyacrylate), Sepi Control® A5 (Capryloylglycine, Methylglycine, Cinnamonum zeylanicum).

0090Furthermore, can be included as additional active ingredients other plant extracts, for example, Birch leaf extract, aloe vera extract, marigold, hibiscus, burdock, Hamamelis, Wassernabelkraut-, algal, quince, water lily, cinnamon extract.

0091It can also be cooled / soothing agents such Frescolat® ML (menthyl Lactate) or Eashave® (Sodium Hyaluronate, Wheat Germ Extract, Saccharomyces cerevisiae extract) are incorporated.

0092Moreover, circulation-promoting agents as an additive materials, eg Nicotinic acid derivatives such as methyl or tocopheryl, alpha- and Beta hydroxy acids and their derivatives such as glycolic, malic, citric, wine-lactic acid, Salicylic acid, Isopropylbenzylsalicylate, C12 - 13 alkyl lactates (Cosmacol ELI) or else antiphlogistic and antibacterial substances, such as Triterpenes, for example ursolic acid, glycyrrhizinic acid or glycyrrhetinic acid and Derivatives, eg stearyl glycyrrhetinate, Kaliumglycyrrhinat; Pantothenic acid derivatives, such as D-panthenol, Panthenyltriacetat; allantoin; bisabolol; Azulenes, including Cham azulenes or Guaj-azulene; phytosphingosine; triclosan; Chlorhexidine derivatives and / or antidandruff agents, eg. B. Climbazol or Piroctone olamine.

0093In addition to the compositions of the invention also antioxidative and cell-protecting effect, such as flavonoids, including rutin, Ferulic acid and esters thereof or isoflavones such as soy isoflavones or coenzyme Q 10 used as effective additives.

0094Very particular preference additional active ingredient combinations of a) - f) or a) - i) or a) + c) - i). These can then in a suitable manner with the following conventional additives described are combined.

<b>2) Conventional additives</b>

0095These are preferably selected from:<sl><li>Antioxidants, perfume substances, dyes, UV filters, preservatives and / or humectants, stabilizers, consistency regulators.</li><li>The antioxidants can preferably be chosen from butylhydroxytoluene, Butylhydroxyanisole, ascorbyl palmitate, tocopherol, possibly in combination with Synergists as in Controx® VP (tocopherol, Lecithin, Ascorbyl Palmitate, Hydrogenated Palm Glycerides Citrate), gallic such as octyl, Dodecyl and Cetylgallat or combinations thereof.</li><li>Perfumes are especially chosen from essential oils. Further, also standard commercial perfume compositions possible such as Deliana perfume oil.</li><li>Essential oils, which are suitable for the compositions of the invention are, in particular, the essential oils selected from rosemary oil, orange oil, Lavender oil, lime oil, cinnamon oil, geranium oil, cedarwood oil, rosewood oil, Valerian oil, ylang ylang oil, citronella oil, tea tree oil, manuka oil, eucalyptus oil, Mentha oil, lemongrass oil, cypress oil, niaouli, pine needle oil, pine needle oil, Camphor, menthol.</li><li>These additives may also be regarded as additional active ingredients. To this end, then also include essential unsaturated fatty acids and their esters, for example Linoleic or linolenic acid, glyceryl linoleate, glyceryl linolenate used will. </li><li>Particularly preferred perfume or additional active substances are selected from essential oils, plant extracts and oils, sebum-regulating substances, Humectants, antiphlogistic and antibacterial substances, Vitamins, unsaturated essential fatty acids or mixtures thereof.</li></sl>

0096Preferred dyes are. Patent Blue, Amidoblau, Orange RGL, Cochineal, dye FD + C Blue No.1 or titanium dioxide or quinoline.

0097Suitable UV filters are, UVB, UVA and broadband filters of the following type:<sl><li>UV-B filters: cinnamic esters, such as octyl methoxycinnamate (Eusolex 2292, Neo Heliopan® AV, Parsol MCX), isoamyl p-methoxycinnamate (Neo Heliopan® Galanga) and 4-methylbenzylidene camphor (Eusolex 6300), Para-aminobenzoic acid and esters such as N, N-dimethyl-4-aminobenzoic acid 2-ethylhexyl ester (Eusolex® 6007, octyl dimethyl PABA), Homomenthylsacilylat (Homosalate Eusolex® HMS), octyl salicylate (Neo Heliopan® OS), octocrylene (Neo Heliopan® 303) Phenylbenzimidazolesulfonic Acid (Neo Heolipan® Hydro, Eusolex® 232)</li><li>UVA + UVB filters for broadband absorption, such as benzophenone-3 (Neo® Heliopan BB, Eusolex® 4360);</li><li>UVA filters such as methyl anthranilate (Neo Heliopan® MA), butyl Methoxydibenzoylmethane (Parsol 1789, Eusolex® 9020); Methylene Bis-benzotriazolyl Tetramethylbutylphenol (Tinosorb® M), bis-Ethylhexyloxyphenol Methoxyphenyltriazin (Tinosorb® S), Disodium phenyl Dibenzimidazole Tetrasulfonate (Neo Heliopan® AP).</li></sl>

0098Particularly preferred are octyl or isoamyl p-methoxycinnamate, Octocrylene, 4-methylbenzylidene camphor, Homo salads and / or butyl Methoxydibenzoylmethane and / or benzophenone-third

0099Also suitable are inorganic UV filters such as zinc oxide and titanium particularly micronized and / or coated, for example Z-Cote®, Tioveil®.

0100Suitable preservatives are iodopropynylbutylcarbamate, DMDM Hydantoin, phenoxyethanol and further customary preservatives, such as eg sorbic and dehydroacetic and salts thereof, methyldibromoglutanonitrile, etc. or combinations thereof, or other acids such as benzoic or Salicylic acid, or benzyl alcohol or esters, such as p-hydroxy benzoic acid ester, for example, methyl, ethyl, propyl, butyl, iso-butyl paraben, preferably methyl or thereof propyl paraben or mixtures or Climbazol or appropriate Combinations of said substances such as methyl paraben, propyl paraben and Sorbic acid in question. In particular suitable are mixtures of, for example from DMDM Hydantoin and iodopropynylbutylcarbamate as Glydant® plus.

0101Also suitable are humectants, eg polyalcohols such as polyethylene glycol, Propylene glycol, butylene glycol, sorbitol, glycerol or polymers, for example Polyquaternium types such as Polyquaternium -39 (Merquat plus 3330), proteins such as collagen or its hydrolysates, amino acids, urea, D-panthenol, vegetable proteins such as from wheat, soy or almond or their Hydrolysates, eg Tritisol® (Hydrolyzed Wheat Protein), polysaccharides such as Fucogel® 1000 (Biosaccharide Gum-1), glycosaminoglycans such as hyaluronic acid or sulfated glycosaminoglycans such as chondroitin sulfate, dermatan sulfate, Keratan sulfate, heparan sulfate, in particular their Na salts or heparin-Na, Glucans such as β-glucan, such as oat β-glucan (Drago-β-Glucan®), mannans as Konjac mannan, algae extracts, such as SU Seamannin® or commercial Humectants such as Hydractin® (Glycerin, Aqua, Disodium Adenosine Triphosphate, Algin, Carica Papaya) or Aquaderm® (Sodium PCA, Sodium Lactate, Fructose, Glycine, niacinamide, urea, inositol), salts such as sodium lactate, DL-2-Pyrrolidone-5-carboxylic acid, sodium salt.

0102Polyethylene / propylene glycol or glycerin are preferably used in amounts of zB0,5- 10%, especially 2 to 5%, and polysaccharide compounds such as Fucogel® 1000th

0103Stabilizers suitable for a wax products such. B. Lunacera® alba (Cera alba), Lunacera® M (Cera Microcristallina) Cutina.RTM HR (Hydrogenated Castor Oil) or silicone waxes, eg Abil.RTM Wax 9800 (Stearyl Dimethicone). Furthermore, Amerchol® CAB can consisting of Vaseline and Lanolin may be used as stabilizers.

0104Secondly, as stabilizers components for pH regulation usable as NaOH (eg 5% strength, for example in amounts of 0.1- 4%, particularly 1-3%) or acids such as citric acid, lactic acid or malic acid, or EDTA Na in a suitable amount as complexing. The amount and type of pH Regulators, depends on other additives from and are the Expert.

0105In particular, as a stabilizer a combination of one or more Acrylamides, one or more acrylates and one or more Polysaccharides, in particular starch, or starch derivatives suitable, each component in an amount of 0.05-8%, preferably 0.1-5% be included can.

0106Particularly preferred acrylamides are polyacrylamide, eg Flocare® T 920 GC or mixtures such Polyacrylamidhaltige Sepigel® 305 (polyacrylamide, C13-14 Isoparaffin, laureth-7), Sepigel® 501 (acrylamide copolymer, Mineral Oil, C13-14 Isoparaffin, Polysorbate 85), Sepigel® 502 (C13-14 isoparaffin, isostearyl Isostearate, sodium polyacrylate, polyacrylamide, polysorbate 20), Creagel® EZ DC (polyacrylamide, polydecene, dimethicone copolyol), Creagel® EZ 5 (Polyacrylamide, polydecene, Laureth-5).

0107As acrylates carboxy vinyl copolymers are high Molecular weight (1 - 3 million), and their copolymers used in particular after neutralization by alkali. Preferably, under the INCI names are Carbomer known Carbopol® types, eg Carbopol® 910, 934, 940, 941, 954, 980, 981, 2984, 5984 or Carbopol® ETD 2001 2050 or Synthalen® K, L, M or the already neutralized carbomers such PNC® 400, 410, 430 (INCI: Sodium Carbomer). It can also be used to acrylate copolymers, such as Arylates / C10-30 Alkyl Acrylate Crosspolymer, known as Carbopol® 1342, 1382 ETD 2020 Pemulen.RTM TR-1, TR-2.

0108As starch, or starch derivatives, the following substances are particularly suitable: Rice, wheat, corn and potato starch.

0109Especially preferred are hydrophobically modified starches, such as aluminum Starch Octenylsuccinate (Dry Flo® PC, Fluidamid® DF 12) or its Mixtures as Natrasorb® HFB (aluminum starch octenyl succinates, Acrylates Copolymer, magnesium carbonate), ASO / MM3® (Aluminium Starch Octenylsuccinate, Magnesium Myristate), Dry Flo® Elite LL (Aluminium Starch Octenylsuccinate, Lauroyl Lysine), Facemat® (Aluminium Starch Octenylsuccinate, Mica, Zea Mays (Corn) Starch, Silica, Titanium Dioxide, Zinc Oxides).

0110Very particular preference is Dry Flo® PC and Natrasorb® HFB.

0111The above combination of stabilizers can also in particular Use of O / W emulsifiers are used.

0112Particularly preferred is Sepigel®305 or 501 PNC®410 / 400 or Carbopol®ETD2020 and Dry Flo®PC or Natrasorb®HFB, especially Combinations thereof.

0113Preference preservatives, antioxidants, dyes and perfumes together with stabilizers and humectants and additional active ingredients optionally in Conjunction with pH regulators as additives, particularly preferably in Affiliated with the above additional active ingredients.

0114The amounts of additives or active ingredients in the identified areas vary.

0115Preferred additives are selected from additional active ingredients such as vitamins, Electrolytes such as magnesium sulphate and sodium chloride, allantoin, D-panthenol, Hyaluronic acid, mucopolysaccharides such as heparinoids and non-heparinoids and mixtures thereof, as well as perfumes, Preservatives and humectants.

0116These can preferably with waxes and / or lecithins such as in particular Phosal®50SA be combined.

0117The containing Zwiebelextrakt- described agent may be prepared, by onion extract preferably with additives soluble therein united, then preparing the fat phase, wherein there preferably soluble additives may be incorporated, and then preparing the water phase, which preferably additives soluble therein and in particular alcohols of the above said type and amount comprises, and then the water and the fat phase at temperatures of 60 to 90 ° C together with one or more thereof emulsifiers or mixtures or emulsified with coemulsifiers, if necessary homogenized and, after cooling (for example at 20-50 ° C), the additives, if yet, adds and worked up in a suitable manner, for example by Homogenize.

0118On the other hand, the onion extract together with the additives in the Fat (oil) phase are incorporated, where optionally also solvents, in particular Alcohols of the above mentioned type and amount can be added.

0119As onion extract is of particular desired aqueous, alcoholic, alcoholic-solvent-based or aqueous-alcoholic or mixtures thereof, for example in the ratio 3: 1 to 1: 3 as the latter two, in the stated amounts selected.

0120A prepared as described above is particularly suitable means for example as dermatological composition for the care, treatment or prevention of of damaged skin tissue, in particular, scar tissue, or slackened Fabrics such as stretch marks, or else of damaged Skin tissue, which may have arisen due to cuts, Surgical wounds, burns or by age-related degeneration.

0121The damaged skin tissue shows after a short time an improvement the scarred or damaged components and thanks to the new oil phases containing formulation beyond even much softer, more supple and elastic are obtained than without this care, skin regenerating additive.

0122Thus, the agent even in scars after cosmetic surgery or for the treatment of acne scars, surprisingly with exceedingly regenerative success are used.

0123The invention is further illustrated by the following examples.

0124In Examples 1-6, an aqueous-ethanolic onion extract, a particular with a proportion of 13-20% ethanol and in Examples 7,8 Alcohol-containing, namely ethanol and medium to triglyceride (about 60%) containing onion extract used. In Examples 9, 10, the Effectiveness based medical surveillances indicated.

example 1

0125<tables><table><tgroup cols="2"><tbody><row><entry align="left">Purified water</entry><entry align="center">34.7879</entry></row><row><entry align="left">magnesium sulfate</entry><entry align="center">0.7000</entry></row><row><entry align="left">Arlacel 582 Nena</entry><entry align="center">8.0000</entry></row><row><entry align="left">Arlatone TV</entry><entry align="center">1.5000</entry></row></tbody></tgroup></table></tables><tables><table><tgroup cols="2"><tbody><row><entry align="left">Lunacera alba</entry><entry align="center">2.0000</entry></row><row><entry align="left">Lunacera M</entry><entry align="center">2.0000</entry></row><row><entry align="left">magnesium stearate</entry><entry align="center">2.0000</entry></row><row><entry align="left">Amerchol CAB</entry><entry align="center">5,0000</entry></row><row><entry align="left">Cetiol OE</entry><entry align="center">5,0000</entry></row><row><entry align="left">Paraffinum Perliquidum</entry><entry align="center">10,0000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">3,0000</entry></row><row><entry align="left">Evening primrose oil</entry><entry align="center">2.0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">0,5500</entry></row><row><entry align="left">Oxynex 2004</entry><entry align="center">0.0500</entry></row><row><entry align="left">Glydant plus</entry><entry align="center">0.2000</entry></row><row><entry align="left">propylene glycol</entry><entry align="center">4,0000</entry></row><row><entry align="left">D-panthenol</entry><entry align="center">5.5000</entry></row><row><entry align="left">allantoin</entry><entry align="center">1.0000</entry></row><row><entry align="left">hyaluronic acid</entry><entry align="center">0.0100</entry></row><row><entry align="left">chondroitin sulfate</entry><entry align="center">0.2000</entry></row><row><entry align="left">onion extract</entry><entry align="center">10,0000</entry></row><row><entry align="left">Dye pigment paste</entry><entry align="center">2.0000</entry></row><row><entry align="left">Dye FD + C Blue No. 1</entry><entry align="center">0.0003</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">0,5000</entry></row></tbody></tgroup></table></tables>

example 2

0126<tables><table><tgroup cols="2"><tbody><row><entry align="left">Purified water</entry><entry align="center">51.7879</entry></row><row><entry align="left">sodium chloride</entry><entry align="center">0,5000</entry></row><row><entry align="left">Abil EM 90</entry><entry align="center">2.5000</entry></row><row><entry align="left">Abil Wax 9800</entry><entry align="center">1.0000</entry></row><row><entry align="left">jojoba</entry><entry align="center">1.0000</entry></row><row><entry align="left">Arlamol HD</entry><entry align="center">5,0000</entry></row><row><entry align="left">CeTiO OE</entry><entry align="center">4,0000</entry></row><row><entry align="left">Lunacera M</entry><entry align="center">0.6000</entry></row><row><entry align="left">Cutina HR Powder</entry><entry align="center">0,4000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">3,0000</entry></row></tbody></tgroup></table></tables><tables><table><tgroup cols="2"><tbody><row><entry align="left">Evening primrose oil</entry><entry align="center">2.0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">0,5500</entry></row><row><entry align="left">Oxynex 2004</entry><entry align="center">0.0500</entry></row><row><entry align="left">Dow Corning 345 fluid</entry><entry align="center">4,0000</entry></row><row><entry align="left">Glydant plus</entry><entry align="center">0.2000</entry></row><row><entry align="left">propylene glycol</entry><entry align="center">4,0000</entry></row><row><entry align="left">D-panthenol</entry><entry align="center">5.5000</entry></row><row><entry align="left">allantoin</entry><entry align="center">1.0000</entry></row><row><entry align="left">Phosal SA 50 New</entry><entry align="center">2.0000</entry></row><row><entry align="left">hyaluronic acid</entry><entry align="center">0.0100</entry></row><row><entry align="left">chondroitin sulfate</entry><entry align="center">0,4000</entry></row><row><entry align="left">onion extract</entry><entry align="center">10,0000</entry></row><row><entry align="left">Dye FD + C Blue No. 1</entry><entry align="center">0.0002</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">0,5000</entry></row></tbody></tgroup></table></tables>

example 3

0127<tables><table><tgroup cols="2"><tbody><row><entry align="left">Purified water</entry><entry align="center">38.7900</entry></row><row><entry align="left">Carbopol ETD 2020</entry><entry align="center">0.2500</entry></row><row><entry align="left">Tego Care 450</entry><entry align="center">3,0000</entry></row><row><entry align="left">Eumulgin B1</entry><entry align="center">2.0000</entry></row><row><entry align="left">Lunacera alba</entry><entry align="center">2.0000</entry></row><row><entry align="left">Kester Wax K82H</entry><entry align="center">3,0000</entry></row><row><entry align="left">Arlamol HD</entry><entry align="center">1.5000</entry></row><row><entry align="left">Cetiol SB 45</entry><entry align="center">2.0000</entry></row><row><entry align="left">Finsolv TN</entry><entry align="center">3,0000</entry></row><row><entry align="left">Dow Corning 345 fluid</entry><entry align="center">2.0000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">3,0000</entry></row><row><entry align="left">Evening primrose oil</entry><entry align="center">2.0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">0,5500</entry></row><row><entry align="left">Oxynex 2004</entry><entry align="center">0.0500</entry></row><row><entry align="left">propylene glycol</entry><entry align="center">4,0000</entry></row><row><entry align="left">Glydant plus</entry><entry align="center">0.2000</entry></row><row><entry align="left">NaOH 5% strength</entry><entry align="center">2.8000</entry></row></tbody></tgroup></table></tables><tables><table><tgroup cols="2"><tbody><row><entry align="left">Trilon BD</entry><entry align="center">0.1000</entry></row><row><entry align="left">panthenol</entry><entry align="center">5.5000</entry></row><row><entry align="left">Hyaluronic acid sodium salt</entry><entry align="center">0.0100</entry></row><row><entry align="left">Phosal SA 50</entry><entry align="center">2.0000</entry></row><row><entry align="left">allantoin</entry><entry align="center">1.0000</entry></row><row><entry align="left">Zincidone</entry><entry align="center">0,5000</entry></row><row><entry align="left">fucogel 1000</entry><entry align="center">5,0000</entry></row><row><entry align="left">Natrasorb HFB</entry><entry align="center">3,0000</entry></row><row><entry align="left">Onion fluid extract</entry><entry align="center">10,0000</entry></row><row><entry align="left">Dye pigment paste white</entry><entry align="center">2.0000</entry></row><row><entry align="left">Sepigel 305</entry><entry align="center">0,5000</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">0,5000</entry></row></tbody></tgroup></table></tables>

example 4

0128<tables><table><tgroup cols="2"><tbody><row><entry align="left">Purified water</entry><entry align="center">33.5900</entry></row><row><entry align="left">Tego Care 450</entry><entry align="center">3,0000</entry></row><row><entry align="left">Eumulgin B1</entry><entry align="center">2.0000</entry></row><row><entry align="left">Lunacera alba</entry><entry align="center">1.0000</entry></row><row><entry align="left">Kester Wax K82H</entry><entry align="center">3,0000</entry></row><row><entry align="left">Arlamol HD</entry><entry align="center">2.5000</entry></row><row><entry align="left">Cetiol SB 45</entry><entry align="center">2.0000</entry></row><row><entry align="left">Finsolv TN</entry><entry align="center">3,0000</entry></row><row><entry align="left">Dow Corning 345 fluid</entry><entry align="center">2.0000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">3,0000</entry></row><row><entry align="left">Evening primrose oil</entry><entry align="center">2.0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">0,5500</entry></row><row><entry align="left">Oxynex 2004</entry><entry align="center">0.0500</entry></row><row><entry align="left">PNC410</entry><entry align="center">0.2000</entry></row><row><entry align="left">propylene glycol</entry><entry align="center">4,0000</entry></row><row><entry align="left">Glydant plus</entry><entry align="center">0,9000</entry></row><row><entry align="left">panthenol</entry><entry align="center">5.5000</entry></row><row><entry align="left">Hyaluronic acid sodium salt</entry><entry align="center">0.0100</entry></row></tbody></tgroup></table></tables><tables><table><tgroup cols="2"><tbody><row><entry align="left">Phosal SA 50</entry><entry align="center">2.0000</entry></row><row><entry align="left">allantoin</entry><entry align="center">1.0000</entry></row><row><entry align="left">Zincidone</entry><entry align="center">0,5000</entry></row><row><entry align="left">fucogel 1000</entry><entry align="center">5,0000</entry></row><row><entry align="left">Sepigel305</entry><entry align="center">0,5000</entry></row><row><entry align="left">Onion fluid extract</entry><entry align="center">10,0000</entry></row><row><entry align="left">Dye pigment paste white</entry><entry align="center">2.0000</entry></row><row><entry align="left">Dry Flow PC</entry><entry align="center">5,0000</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">0,5000</entry></row></tbody></tgroup></table></tables>

example 5

0129<tables><table><tgroup cols="2"><tbody><row><entry align="left">Purified water</entry><entry align="center">41.0900</entry></row><row><entry align="left">Carbopol ETD2020</entry><entry align="center">0.2000</entry></row><row><entry align="left">Dermofeel Q182S</entry><entry align="center">3,0000</entry></row><row><entry align="left">Eumulgin B1</entry><entry align="center">2.0000</entry></row><row><entry align="left">Lunacera alba</entry><entry align="center">2.0000</entry></row><row><entry align="left">Kester Wax K82H</entry><entry align="center">3,0000</entry></row><row><entry align="left">Arlamol HD</entry><entry align="center">5,0000</entry></row><row><entry align="left">Cetiol SB 45</entry><entry align="center">2.0000</entry></row><row><entry align="left">Finsolv TN</entry><entry align="center">3,0000</entry></row><row><entry align="left">Dow Corning 345 fluid</entry><entry align="center">2.0000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">3,0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">0,5500</entry></row><row><entry align="left">Oxynex 2004</entry><entry align="center">0.0500</entry></row><row><entry align="left">propylene glycol</entry><entry align="center">4,0000</entry></row><row><entry align="left">Glydant plus</entry><entry align="center">0.2000</entry></row><row><entry align="left">NaOH 5% strength</entry><entry align="center">1.6000</entry></row><row><entry align="left">panthenol</entry><entry align="center">5.5000</entry></row><row><entry align="left">Hyaluronic acid sodium salt</entry><entry align="center">0.0100</entry></row><row><entry align="left">Phosal SA 50</entry><entry align="center">2.0000</entry></row><row><entry align="left">allantoin</entry><entry align="center">1.0000</entry></row><row><entry align="left">Zincidone</entry><entry align="center">0,5000</entry></row><row><entry align="left">fucogel 1000</entry><entry align="center">5,0000</entry></row></tbody></tgroup></table></tables><tables><table><tgroup cols="2"><tbody><row><entry align="left">Sepigel305</entry><entry align="center">1.0000</entry></row><row><entry align="left">Onion fluid extract</entry><entry align="center">5,0000</entry></row><row><entry align="left">Dye pigment paste white</entry><entry align="center">1.0000</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">0,5000</entry></row><row><entry align="left">Natrasorb HFB</entry><entry align="center">3,0000</entry></row></tbody></tgroup></table></tables>

example 6

0130<tables><table><tgroup cols="2"><tbody><row><entry align="left">Purified water</entry><entry align="center">46.1900</entry></row><row><entry align="left">Carbopol ETD2020</entry><entry align="center">0.2000</entry></row><row><entry align="left">Dermofeel Q182S</entry><entry align="center">3,0000</entry></row><row><entry align="left">Eumulgin B1</entry><entry align="center">2.0000</entry></row><row><entry align="left">Lunacera alba</entry><entry align="center">2.0000</entry></row><row><entry align="left">Kester Wax K82H</entry><entry align="center">1.0000</entry></row><row><entry align="left">Arlamol HD</entry><entry align="center">5,0000</entry></row><row><entry align="left">Cetiol SB 45</entry><entry align="center">2.0000</entry></row><row><entry align="left">Finsolv TN</entry><entry align="center">3,0000</entry></row><row><entry align="left">Dow Corning 345 fluid</entry><entry align="center">2.0000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">3,0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">0,5500</entry></row><row><entry align="left">Oxynex 2004</entry><entry align="center">0.0500</entry></row><row><entry align="left">PNC 410</entry><entry align="center">0.6000</entry></row><row><entry align="left">propylene glycol</entry><entry align="center">4,0000</entry></row><row><entry align="left">Glydant plus</entry><entry align="center">0.2000</entry></row><row><entry align="left">NaOH 5% strength</entry><entry align="center">1.6000</entry></row><row><entry align="left">panthenol</entry><entry align="center">5.5000</entry></row><row><entry align="left">Hyaluronic acid sodium salt</entry><entry align="center">0.0100</entry></row><row><entry align="left">Phosal SA 50</entry><entry align="center">2.0000</entry></row><row><entry align="left">allantoin</entry><entry align="center">1.0000</entry></row><row><entry align="left">Zincidone</entry><entry align="center">0,5000</entry></row><row><entry align="left">fucogel 1000</entry><entry align="center">5,0000</entry></row><row><entry align="left">Sepigel305</entry><entry align="center">0.3000</entry></row><row><entry align="left">Onion fluid extract</entry><entry align="center">5,0000</entry></row></tbody></tgroup></table></tables><tables><table><tgroup cols="2"><tbody><row><entry align="left">Dye pigment paste white</entry><entry align="center">1.0000</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">0,5000</entry></row><row><entry align="left">Natrasorb HFB</entry><entry align="center">3,0000</entry></row></tbody></tgroup></table></tables>

example 7

0131<tables><table><tgroup cols="2"><tbody><row><entry align="left">Miglyol 812</entry><entry align="center">73.9000</entry></row><row><entry align="left">onion extract</entry><entry align="center">2.0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">1.1000</entry></row><row><entry align="left">Evening primrose oil</entry><entry align="center">2.0000</entry></row><row><entry align="left">jojoba</entry><entry align="center">5,0000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">5,0000</entry></row><row><entry align="left">Cetiol PGL</entry><entry align="center">10,0000</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">1.0000</entry></row></tbody></tgroup></table></tables>

example 8

0132<tables><table><tgroup cols="2"><tbody><row><entry align="left">Miglyol 812</entry><entry align="center">86.9000</entry></row><row><entry align="left">onion extract</entry><entry align="center">2.0000</entry></row><row><entry align="left">tocopherol</entry><entry align="center">1.1000</entry></row><row><entry align="left">Evening primrose oil</entry><entry align="center">2.0000</entry></row><row><entry align="left">jojoba</entry><entry align="center">3,0000</entry></row><row><entry align="left">Cosmacol® ELI</entry><entry align="center">5,0000</entry></row><row><entry align="left">Deliana perfume oil</entry><entry align="center">0.7000</entry></row></tbody></tgroup></table></tables>

example 9

<b>Medical surveillance with patients with different scars</b>

0133In 338 patients (62% female) with an average age of 41 years were lacerations (45), abrasions (14), surgical wounds (240) Burn scars (18), acne scars (6) or other scars (15) in the head / Neck region (65), arms (135), legs (84), the upper body / chest (27), Waist / back (14) or elsewhere (54) over a period of <1 Month (106) to 3 months (117) or> 3 months available. These patients were for a period up to 6 months with a product according to present Example 1 by application to the affected area of ​​skin Average 2x treated daily. Prior to treatment in approximately 15% was the Cases an application of known products such as onion extract gel (Contractubex) or Ketofibrase been undertaken without further success. During treatment of the invention, an assessment was in terms of smoothing the skin (appearance of the scar like other skin or slightly or grossly hardened, reducing scar depth, length), the skin compatibility (Spreadability, absorption, odor, feel on the skin). The results are in Table 1 below illustrated and show that the invention Product had resulted in over 90% of cases, to a positive result.<tables><table><tgroup cols="3"><tbody><row><entry align="left"><u>Scar smoothing:</u></entry><entry align="center"><u>Overall doctor</u></entry><entry align="center"><u>assessing patient</u></entry></row><row><entry align="left">a) Very good</entry><entry align="center">45,0%</entry><entry align="center">46.7%</entry></row><row><entry align="left">b) good</entry><entry align="center">47.6%</entry><entry align="center">44.7%</entry></row><row><entry align="left">c) moderate</entry><entry align="center">5.6%</entry><entry align="center">8.0%</entry></row><row><entry align="left"><u><i>Overall rating a) + b)</i></u></entry><entry align="center"><u><i>91.4%</i></u></entry><entry align="center"><u><i>92.6%</i></u></entry></row><row><entry align="left"><u>Skin compatibility:</u></entry></row><row><entry align="left">a) very good</entry><entry align="center">75.9%</entry><entry align="center">70.3%</entry></row><row><entry align="left">b) good</entry><entry align="center">23.2%</entry><entry align="center">28.5%</entry></row><row><entry align="left">c) moderate</entry><entry align="center">0.9%</entry><entry align="center">1.2%</entry></row><row><entry align="left"><u><i>Overall rating a) + b)</i></u></entry><entry align="center"><u><i>99, 1%</i></u></entry><entry align="center"><u><i>98.8%</i></u></entry></row></tbody></tgroup></table></tables>

Example 10:

<b>Medical surveillance in the prevention and treatment of stretch marks</b>

0134741 subjects were from the 16th week of pregnancy in terms of training, prevention of stretch marks over a observed period of 5-7 months to 8 weeks after birth and with a product according to Example 2 above on abdomen, chest and Thigh 1-2x daily treated. At the beginning of the study 62.5% no stripes, at 37, 3% marks (of which 19.2% was slightly, 14.7% many slight, 3.4% many strong) ago. Of the subjects, 65.8% were Primiparas (7% with) and 34.1% multiple parturient (Of which 29.1% had marks). After the observation period was found that despite an average weight gain of approximately 12 kg at 35.9 % No stretch marks developed and only 37.1% few faint stripes occurring while 21.3% many slight and only 5.7% thick stripes were observed. The inventive product is therefore extremely well suited to effectively prevent or Reduction of stretch marks, which from the in Table 2 mentioned judgment values ​​obtained (criteria analogous to Example 9) clearly.<tables><table><tgroup cols="3"><tbody><row><entry align="left"><u>Development stripes:</u></entry><entry align="center"><u>Overall doctor</u></entry><entry align="center"><u>assessing patient</u></entry></row><row><entry align="left">a) Very good</entry><entry align="center">53.0%</entry><entry align="center">51.1%</entry></row><row><entry align="left">b) good</entry><entry align="center">39.0%</entry><entry align="center">40.1%</entry></row><row><entry align="left">c) moderate</entry><entry align="center">7.0%</entry><entry align="center">6.0%</entry></row><row><entry align="left">d) poor</entry><entry align="center">1.0%</entry><entry align="center">2.3%</entry></row><row><entry align="left"><u><i>Overall rating a) + b)</i></u></entry><entry align="center"><u><i>92.0%</i></u></entry><entry align="center"><u><i>91.1%</i></u></entry></row><row><entry align="left"><u>Skin compatibility:</u></entry><entry align="center"><u>Overall doctor</u></entry><entry align="center"><u>assessing patient</u></entry></row><row><entry align="left">a) very good</entry><entry align="center">69.6%</entry><entry align="center">75.7%</entry></row><row><entry align="left">b) good</entry><entry align="center">28.1%</entry><entry align="center">22.9%</entry></row><row><entry align="left">c) moderate</entry><entry align="center">0.9%</entry><entry align="center">0.9%</entry></row><row><entry align="left"><u><i>Overall rating a) + b)</i></u></entry><entry align="center"><u><i>97.7%</i></u></entry><entry align="center"><u><i>98, 6%</i></u></entry></row></tbody></tgroup></table></tables>