Inhaler for powdery, in particular, medical substances

p0001The invention relates to an inhaler for powdered, in particular medical substances, with a suction air channel leading to a mouthpiece, a supply chamber for the substance and a linearly moving metering chamber for separating a certain amount of substance from the supply chamber into the region of a transfer point to the suction air stream.

p0002An inhaler of this type is characterized by the <patcit id="pcit0001" dnum="DEOS4027391A"><text>DE-OS 40 27 391</text></patcit> known. The quantity of substance to be dispensed is transferred to the dispensing chamber which can be moved out in a downwardly discharging storage chamber. The dispenser is a linearly movable slide having these. Placed in the channel of the mouthpiece, a rear chamber of the dosing chamber is docked to an air volume stored in a piston / cylinder unit. By exerting the inspiration in the sense of a suction air stream, the air volume is triggered and released in the form of a stroke. The suction stroke, which is so mechanically flow-assisted, cleans the dosing chamber emptying freely. The compressed air ejection to be triggered by the negative pressure requires a considerable construction expenditure; Also the suddenly occurring air pressure is at least very habituation for most patients at least.

p0003Inhalers are from the printings <patcit id="pcit0002" dnum="WO0121238A2"><text>WO 01/21238 A2</text></patcit>, <patcit id="pcit0003" dnum="US5239992A"><text>US 5,239,992</text></patcit>, <patcit id="pcit0004" dnum="DE10047722A1"><text>DE 100 47 722 A1</text></patcit> and <patcit id="pcit0005" dnum="US5492122A"><text>US 5,492,122</text></patcit> known.

p0004The object of the invention is to design a generic inhaler in a structurally simple manner in such a way that the addition of a foreign air stream can be dispensed with, but nevertheless a rest-free discharge of a reproducible partial quantity is given.

p0005This object is achieved by the subject matter of the independent claim, wherein, inter alia, a component of the suction air stream lying in the direction of extension of the metering chamber empties the metering chamber.

p0006According to such a configuration, a structurally simple, functionally safe inhaler is achieved. The inhalation provides sufficient discharge negative pressure that the dosing chamber is emptied properly. The presentation area to the flow component is extremely effective. The linearly moving dosing chamber works exhaustively and, when the transfer station is reached, is separated from the storage area of ​​the powdered substance in such a way that nothing can fall back. The prior art attempts to prevent these sources, which may lead to unequal batches, by the use of a sieve to the rear space, that is, to the incoming air flow.

p0007It is further proposed that the dosing chamber is designed as a transverse bore of a mandrel which can be displaced in a manner depending on the closure cap. The dispensing standby position is, as it were, automatically accomplished, simply in the usual handling of the closing and opening. The preferably continuous transverse bore can be cleared from two sides. A particularly effective measure results from a conical transverse bore. The separated substance quantity is passed from the far end even more rapidly via component to the suction air stream. In order to obtain an air guide of the component which is conductive in the direction of extension of the metering chamber, it is important that an air passage adjoining the suction air stream is assigned to the metering chamber. This results, as it were, in a localized zone of the vacuum. It is advantageous to preload an air passage to each open end of the dosing chamber. In the case of the conical transverse borehole, it is expediently also proceeded in such a way that an air passage of smaller diameter is assigned to the end of larger light diameter of the metering chamber, and an air passage of larger diameter than the end of smaller diameter. According to the larger side, larger negative pressure is therefore predominantly removed from the wide side, ie straight in the direction in which there is no obstruction of friction due to the correspondingly widening wall of the dosing chamber. The invention then proposes that the air passages be formed on a pot-shaped rotary part which guides the mandrel and are in flow connection with air inlets of the jacket wall of an mouthpiece. The corresponding air inlets are placed on the jacket side of the inhaler so that they can neither be held by the user's lips nor by the gripping hand, which comprises the rod-shaped body of the inhaler. Moreover, the danger of stopping is minimized by the formation of a plurality of air inlets spaced apart from each other. In the sense of a good distribution of the pulverulent substance to the suction air stream, the air passages are arranged axially offset to the air inlets adjacent to the mouthpiece. This results in a first opposing flow path. In addition, it proves to be advantageous that the rotary part forms with its pot bottom the ceiling of the supply chamber, the center of which has a guide opening for the mandrel acting as a dipping slide. The bottom of the pot thus has a double function: medium or direct cover and guide hole for the mandrel. Furthermore, an advantageous feature is that the mandrel, which is sharpened in the manner of a screwdriver at the end in the direction of immersion, is rotationally connected to the rotary part by means of radial wings. On the one hand, the blade-like blade achieved in this way, in addition to an effective rotational loosening effect in the center region, at the same time promotes the immersion of the mandrel in the powder lake, and on the other hand there is a welcome support of the mandrel opposite the rotary part and, moreover, the orientation of the air passages to the dosing chamber power. The necessary linear relative movement of the mandrel and the rotating part relative to one another is achieved by means of simple means in that the pot wall of the pot-shaped rotating part has axial guide slots in which the wings extend. This solution is further characterized by a tensile limit stop of the mandrel provided by the mouthpiece, defining the emptying-ready position of the dosing chamber which, with its base wall section, provides the transfer point. The closure cap-dependent bearing of the mandrel is further characterized by a docking point between the mandrel and the closure cap which is located on the mouth side and is disengaged in the event of an overload. When the inhaler is closed again, the re-docking between the mandrel and the closure cap results. An embodiment of even independent significance is then embodied in the fact that the rotary part has a rotor, to which a stator is assigned, with a vane effect which acts in the dosing chamber when the rotary part rotates back. The dispensing and also the density of the powder quantities in the dosing chamber are equally durable. In addition, there is a loosening effect in the environment which prevents the stopping of powder particles. Reverse rotation means unscrewing the closure cap and the associated charging effect of the dosing chamber. Specifically, the paddle is formed by rotor blades supported by a ring disk of the bottom of the rotating member. The latter have lancet or crescent-shaped contours. Two diametrically opposite rotor blades are realized. Concretely, the rotor blades extend essentially in a quarter sector with a flank which is oriented radially to the center of the mandrel and a blade edge which is approximately at a right angle to the mandrel. This excludes crushing sites. The medical substance, for example, which is attached to a carrier, is not rubbed off by this carrier. It is then provided that the flanks lie in a common diametral. The further constructional design is also shovel-efficient, but has a medication-protecting design in that the rotor engages the stator in such a way that the stator is designed as a projection projecting radially inward from the inner wall of the storage chamber and extending freely into a rotational path of the rotor. The stator has a trapezoidal outline and is rooted with its base in the inner wall of the supply chamber. The orbital path is axially bounded by the underside of the annular disk of the rotary part and the inner side of the rotor blades facing it. Furthermore, a design-favorable embodiment consists in the fact that the stator is arranged under the quarter sector leaving an interspace between two rotor blades. This provides a sufficiently large mounting opening. Both sealing and guidance is advantageous when the guide opening in the rotating part is formed by a sealing bushing comprising the cylindrical section of the mandrel. It may be rubber or rubber-like material. The pulverulent substance deposited on the shank of the mandrel is stripped through the sealing bush. There is no falsification of the dosage dose. A likewise gasket-related measure of the dispenser mechanism results from a sealing ring inserted between the inner wall of the supply chamber and the rotating part with pretension. Rubber or rubbery material can also be used here. It is then provided that the sealing ring is snapped into annular grooves of the two parts, the annular groove located on the rotary part being realized as a V-shaped notch groove, and the annular groove of the supply chamber lying parallel thereto being half-round. The former functions as a rotary guide of the rotary part. Finally, it is proposed that the closure cap be designed as a screw cap and interacts with the mouthpiece via rotary means of rotation. The latter are claw-clutch-like and are disengaged during thread separation.

p0008The subject matter of the invention is explained in more detail below with reference to a illustratively illustrated exemplary embodiment. It shows:<dl id="dl0001" compact="compact"><dt>FIG</dt><dd>The inhaler according to the invention in the vertical section, enlarged, in a cap-closed basic position,</dd><dt>FIG</dt><dd>The plan view,</dd><dt>FIG</dt><dd>The inhaler in side view,</dd><dt>FIG</dt><dd>The inhaler in section as <figref idrefs="f0001">FIG</figref>, But with the cap removed, thus embodying the withdrawal-ready position,</dd><dt>FIG</dt><dd>An enlargement of the <figref idrefs="f0001">FIG</figref> With a mandrel arranged in an intermediate position, the dosing chamber extending at the level of the stator,</dd><dt>FIG</dt><dd>The section according to line VI-VI in FIG <figref idrefs="f0003">FIG</figref>,</dd><dt>FIG</dt><dd>A detailed view of the rotating part with rotor and stator in a frog perspective, showing the cutting-like shape of the lower spike end, </dd><dt>FIG</dt><dd>An exploded view of the parts forming the inhaler with respect to all the parts in the vertical section with respect to the mandrel in a partial section.</dd></dl>

p0009The inhaler 1 shown in the drawing is realized as a convenient, short-bar-shaped pocket device. In this case, an offset, cylindrical housing 2 is determined.

p0010The cylindrical, tube-like housing 2 transitions into an attached mouthpiece 3 on the head side of the inhaler 1. This is smoothly flattened and can be protected by means of a cup-shaped closure cap 4 in a protective manner.

p0011The closure cap 4 is implemented as a screw cap. An internal thread 5 assigned to it engages in a corresponding external thread 6 on the casing wall of the housing 2. A clip 7 is formed on the closure cap 4 in the region of the mouth of the mouthpiece 3.

p0012On the side of the foot, the end edge of the cup-shaped closure cap 4 abuts against an annular shoulder 8, achieved by virtue of the abovementioned shoulder of the cylindrical housing 2.

p0013Using the axial screw stroke of the threaded engagement 5/6, the closure cap 4 simultaneously acts as an actuating handle 9 for applying a powdered substance 10 in reproducible partial quantities 10 ', which substance is accommodated in a supply chamber 11 of the housing 2, if necessary, refillably. The dispensing device, which in each case feeds a partial quantity 10 'to a transfer station Ü located outside the storage chamber 11, is denoted by D in its entirety.

p0014The material to be dosed is a medicinal powdery substance 10, for example, the property that carrier substances transportable by suction (lactose) as a vehicle have the micronized pharmaceutical fine particles attached thereto on the surface side.

p0015Downstream of the metering device D is a so-called dispersing region in which a suction air stream S is produced by the user which removes the exactly separated partial quantity 10 'of the substance 10 in the transfer station U free of any residues. The suction air duct leading to the mouthpiece 3 bears the reference numeral 12.

p0016The lower end of the supply chamber 11 is formed by a cup-shaped pressure plate 13 which is spring-loaded in the direction of the mouthpiece 3. The corresponding pressure spring bears the reference numeral 14. The end cap bears against the bottom cap 15 closing the housing 2. The latter is in ratchet engagement with the portion of the housing 2 which is larger in cross-section thereabove. The corresponding locking collar 16 engages in a suitable annular groove of the housing 2.

p0017The head end winding of the pretensioned compression spring 14 loads an inner shoulder 17 of a hollow piston 18 of the piston-shaped device 13/18.

p0018The pressure plate-shaped pressure plate 13 is connected to the inner shoulder 17 in a ratchet-like manner.

p0019The top edge of the pressure base 13 provides an annular lip 19 which, due to its rubber-elastic material, strips the wall of the supply chamber 21 in a loss-free manner.

p0020A plug 20 is then removed centrally from the bottom cap 15. This is hollow and, together with the hollow piston 18, forms a spring chamber 21 for the compression spring 14.

p0021On the mouth side, the storage chamber 11 closes with a pot-shaped rotating part 22. This forms with its cup bottom the cover 23 of the supply chamber 11 which covers the housing 2.

p0022A guide opening 24 is left in the center of the ceiling 23. This centrally or directly designed guide opening 24 receives a mandrel 25 as the heart of the metering device D. According to the invention, the latter functions as a linearly moving dosing chamber 26 for the partial quantity 10 'to be discharged, a dipping slide being provided. It moves in the longitudinal center axis xx of the essentially rotationally symmetrical inhaler 1.

p0023On its end facing away from the mouthpiece 3, the mandrel 25 forms a screw-type taper-like tapering. Due to the rotation of the mandrel 25 in the center area, this has a loosening effect with respect to the lake of pulverulent substance 10. The virtually pointed-like blade 27 exhibits two mirror-symmetrical oblique flanks and adjoins a cylindrical shank of the mandrel 25 on the base side. The inclined flanks include an angle of approximately 60 °. The cylindrical basic cross-section of the mandrel 25 is maintained in the region of the blade 27 (see FIG<figref idrefs="f0004">FIG</figref>). In both end positions of the mandrel 25, the stroke travel of the linearly moved metering chamber 26 takes into account the holding of the cross-section of the guide opening 24 with a metering-chamber-filling doctoring or scraping action over the length of the said opening 24.

p0024The mouth-side end of the closure cap 4 forms an anchoring point 28, which is disengaged in the event of an overload, between the mandrel 25 and the closure cap 4. The latching-side latching means is a spring-loaded hook ring. Inwardly directed lugs 29 of the resilient tongues of the hook ring engage in a slot-like annular groove 30 of the mandrel 25. The annular groove 30 continues into a latching head 31. This can be overcome by the lugs 29 in both directions. The resting head accumulation of material is approximately lenticular.

p0025The lugs 29, or their spring tongues, are realized on a tube 32 protruding into the mouth opening 3 ', which extends from the inner side of the closure cap 4. It is rooted in it.

p0026The mandrel 25 is rotationally connected to the rotary part 22 by means of radial blades 33, which are embodied in the manner of a spoke. The wings 33 engage with their free end sections, the suction air channel 12 transversely into axial guide slots 34 -is already three of the rotating part 22 are sufficient. The angularly distributed guide slots 34 are located on the inside of the pot wall 35 of the cup-shaped rotating part 22. The axial guide slots 34 are, moreover, of such a length that the powder-filling immersion stroke of the mandrel 25 from a filling level in the storage chamber 11 into the described transfer point Ü above the ceiling 23 is guaranteed.

p0027The defined emptying-ready position of the metering chamber 26 is obtained by means of a tensile limiting stop of the mandrel 25, which is provided by the mouthpiece 3. This is the end of a reclined wall of the mouthpiece 3, which thus holds the outlet of the guide slots 34.

p0028The mouthpiece 3 engages anchoringly on the neck of the housing 2 via a jacket wall 37. A detent point 38 is formed between the two parts 2, 3 there. It can be an irreversible stop point 38. Moreover, as can be seen, the ceiling 23 of the rotary part 22 is supported by a ring shoulder 39 supported.

p0029The metering chamber 26 is realized as a transverse bore running substantially perpendicular to the longitudinal center axis xx. The dosing chamber 26 is located in the effective range of the central suction air flow S. A dosing chamber 26 is associated with an air passage 40 which adjoins the suction air channel 12. This is formed in the pot wall 35 of the rotary part 22. These are radial bores. They extend in the vicinity of the floor of the cup-shaped rotating part 22, ie, at a height or just above the top of the top 23.

p0030Both the open ends of the metering chamber 26 can be seen to have such an air passage 40 radially spaced apart. In this connection, provision is made that the end of the larger clear diameter of the metering chamber 26, which is formed by a conical transverse bore, is assigned an air passage 40 of smaller diameter than the latter and the end of smaller clear diameter of the metering chamber 26 is an air passage 40 of larger diameter than this. This results in a larger negative pressure behind the air passage 40 of smaller diameter, with a predominant discharge effect with respect to the partial quantity 10 'presented. However, the discharge, ie, emptying, of the dosing chamber takes place from both ends.

p0031The passages 40 formed on the pot-shaped rotary part 22 leading the mandrel 25 are radially spaced apart via a rear annular space 41, and are also fluidly connected to air inlets 42. These are also designed as bores and connect to the atmosphere. The said annular space 41 is located between the outer side of the pot wall 35 of the pot-shaped rotary part 22 and the inner side of the outer wall 37 of the mouthpiece 3.

p0032The air passages 40 are arranged axially offset relative to the air inlets 42. The air inlets 42 are closer to the mouthpiece 3. The described spatial spacing position leads to a initially counterflowing inflow of sucked-in air with connection to the main suction air stream S. This and the fact that a component of the suction air stream S lying in the direction of extension of the metering chamber 26 is built up results in the metering chamber 26 being free of any residues Is emptied. The user inhales a precise dose. The transfer point Ü is here set by the base section of the dosing chamber 26.

p0033The special kind of the powdery substance 10 in the scoop region, developed here, is promoted for the corresponding emptying: in this case, conditions have been created which ensure the desired structurally homogeneous "plug" of the dosing chamber 26 fed from a loosened environment. For this purpose, the rotary part 22 is used in a further developing manner. It has a rotor R acting in the upper region of the supply chamber 11. A stator St is associated with this. By utilizing the rotation of the rotating part 22, in addition to loosening, a powder acting in the metering chamber 26 at the same time also results at the same time as the rotating part 22, ie, when unscrewing the sealing cap 4 by using the same as the actuating handle 9 Wing 33, so that there is no adjustment of the axis of the dosing chamber 26 to the air passages 40. Even the jacket wall 37 could be incorporated into the rotational fixation by means of positive connection means. In general, even a frictional entrainment is sufficient, for example via the annular collar 43 which keeps the annular space 41 toward the mouth-end. This extends from the jacket wall of the pot wall 35 and rests with its edge edge against the inner side of the jacket wall 37 of the mouthpiece 3.

p0034Like the <figref idrefs="f0001">FIG</figref> and <figref idrefs="f0002">4</figref> The rotational movement between the mouthpiece 3 and the screw-releasing closing cap 4 is effected by a claw coupling 44 between the two. This consists of a longitudinal toothing 45 on the jacket wall 37 of the mouthpiece 3, which longitudinal teeth engage in corresponding tooth gaps 46 on the inner side of the closure cap 43.

p0035Blades are formed by two rotor blades 47. These basically have a crescent-shaped outline. The two rotor blades 47 are located diametrically in relation to the longitudinal center axis xx of the inhaler 1. They are held at center-spaced, axially extending webs 48. The roots in the underside of an arm or an annular disk 49 of the rotary part 22 which rotates the rotor.

p0036The free-standing rotor blades 47 protruding from the floor or the ceiling 23 of the rotary part 22 on the chamber side are positioned in such a diametrical counterposition that they are sufficiently spaced in the direction of rotation. Geometrically, they substantially occupy a quarter sector of the circular cross-section of the supply chamber 11. It is up<figref idrefs="f0004">FIG</figref> Respectively. The two rotor blades 47 each have an edge 50 which is aligned radially with respect to the center of the mandrel 25, as well as a blade flank 51 which is at right angles thereto. The blade flank 51 extends in a gap-limiting distance from the shell wall of the mandrel 25. The gap bears the symbol 52 Avoided. The flanks 50 are diametrical. The common diametrale of flanks 50 is in<figref idrefs="f0004">FIG</figref> With yy. The space-parallel blade flanks 51 extend perpendicular to the diametral yy and parallel to the transverse axis zz of the dosing chamber 26, which in turn coincides with the bore axis of the air passages 40.

p0037The ring disk 49 or two arms, in which the rotor blades 47 are rooted, continues into the ceiling 23 of the rotary part 22 via an annular wall 53.

p0038<figref idrefs="f0003">FIG</figref> Shows particularly clearly that the rotor R engages the stator St such that the stator St is formed as a projection extending radially inward from the inner wall of the supply chamber 11 and extending freely into a circular path 54 of the rotor R. The orbit 54 can be seen to be axially bounded by the underside of the annular disk 49 of the rotary part 22 and the inner side of the rotor blades 47 facing it. The axial distance forming the circumferential path is significantly greater than the thickness of the stator St, ie protrusion, measured in this direction. Thus, there is also no mechanical load against the friction-sensitive powdered substance 10 to be dispensed.

p0039The stator St has a trapezoidal outline. Its base in the form of an arc of a circle is rooted in the inner wall of the supply chamber 11. The base is thereby dimensioned in such a way that the stator St which tapers radially towards the inner side is arranged under the quarter sector leaving an intermediate space 55 between two rotor blades 47. That sets aside<figref idrefs="f0004">FIG</figref> A sufficient mounting opening for the latching of the stator into the orbit 54.

p0040The radial projection of the stator St is inwardly of such a radial length that the plateau of the trapezium also terminates in a gap-forming manner in front of the outer side of the web 48.

p0041The blade effect is turned off <figref idrefs="f0004">FIG</figref> Keeping in mind the arrows. Arrow a indicates the reverse rotation direction of the rotary part 22. The blade flanks 51 thus function as the forward-moving powder pushing breast. The arrow b indicates the approximate direction of the dosing with respect to the end of the metering chamber 26 with a larger, clear diameter. Arrow c indicates the corresponding effect on the other rotor blade 47, here also with regard to the shoveling action of the blade edge 51. The stator St is, Path of the orbit 54. The pulverulent substance 10 is rapidly displaced in a chamber-filling manner by the blade edge 51 lying near the deflecting trapezoidal flank, so that, as already stated, the fill conditions are always the same. The metering chamber 26 moves in several rotations ascending through the zone of the metering device D until it reaches the top of the top 23 of the cup-shaped rotating part 22 with its transfer point Ü.

p0042Also, no powder material adhering approximately to the mandrel jacket is entrained in a dose-distorting manner, according to the stripping-acting guide opening 24. The latter is not formed directly by the rotating part 22 but by a sealing bushing 56 lining this passageway Locking means 57. It extends planarly up to the top of the annular disk 49.

p0043However, there is also no radially outwardly lying loophole for powder losses, since between the rotary part 22 and the housing 2 forming the supply chamber 11 there is likewise a sealing element. This is achieved by a sealing ring 58 made of rubber-elastic material inserted between the inner wall of the supply chamber 11 and the rotating part 22. Said sealing ring 58 is used under preload. The sealing ring 58 is nibbled into annular grooves of the two parts 2, 22. The annular groove located on the rotary part 22 bears the reference numeral 59. It is realized as a V-shaped notch groove. The opening angle of the annular groove 59 located in the region of the annular wall 53 is approximately 90 °. The groove contour has centering and rotating effect. The other annular groove 60, which is located at the same height, is located on the inside of the housing 2, namely in the upper input region of the supply chamber 11. Here, with respect to the cross section of the circumferential annular groove 60, a half-round shape is present. A rotationally symmetrical run-up slope 61, which is arranged upstream of the annular groove 60, is facilitated with mounting.

p0044The mandrel 25 designed as a hebedorn can be varied with respect to the volume of its dosing chamber 26, ie, the heart piece of the dosing device D merely needs to be exchanged in order to achieve a different, precisely reproducible dosing of partial quantities 10 '.

p0045The piston-like pressure plate 13 is not impaired in its mobility against the cylinder chamber, provided the middle section of the housing 2, since the housing has an air compensation opening 62 located in the back of the annular lip 19.

p0046The top-shaped pressure base 13 has a central recess which faces away from the supply chamber 11. The inside is of such depth that the end portion of the mandrel 25 protrudes axially in the basic position of the rotor blades 47.

p0047In the following text, examples are given, the individual examples being numbered to facilitate reference to features of individual examples in other examples.<ol><li>(11) for the substance (10) and a linearly moving metering chamber (26), characterized in that the inhaler (1) (S), which is located in the direction of extension of the dosing chamber (26), of the suction air flow (S), the dosing chamber (26) is arranged in the region of a transfer point (Ü) Emptied</li><li>2. Inhaler according to example 1, or in particular according thereto, characterized in that the dosing chamber (26) is designed as a transverse bore of a mandrel (25) which can be displaced as a function of the closure cap. </li><li>3. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized by a conical transverse bore.</li><li>4. Inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that a air passage (40) adjoining the suction air stream (S) is associated with the metering chamber (26).</li><li>5. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized in that an air passage (40) is in each case arranged upstream of the two open ends of the metering chamber (26).</li><li>6. The inhaler according to claim 1, characterized in that an air passage (40) with a smaller diameter is associated with the end of larger diameter of the metering chamber (26), and an air passage (40) is assigned to the end of the smaller clear diameter ) Of larger diameter than this.</li><li>7. The inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that the air passages (40) are formed on a pot-shaped rotary part (22) guiding the mandrel (25) and are connected to air inlets (42) Of the mouthpiece (3).</li><li>8. Inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that the air passages (40) are arranged axially offset to the air inlets (42) which are closer to the mouthpiece (3). </li><li>9. The inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that the rotary part (22) forms with its cup bottom the ceiling (23) of the supply chamber (11), the center of which has a guide opening (24) Slider (25).</li><li>10. Inhaler according to one or more of the preceding examples or, in particular, according to the invention, characterized in that the mandrel (25), which is sharpened in the manner of a screwdriver at the end in the immersion direction, is rotationally connected to the rotating part (22) by means of radial wings (33).</li><li>11. Inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that the pot wall (35) of the pot-shaped rotating part (22) has axial guide slots (34), in which the wings (33) extend.</li><li>12. The inhaler according to one or more of the preceding examples, or in particular according to the invention, characterized by a traction limiting stop (36) of the mandrel (25), arranged by the mouthpiece (3), defining the emptying standby position of the dosing chamber (26) ).</li><li>13. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized by a docking point (28) between the mandrel (25) and the closure cap (4) which is located on the mouth side and is disengaged when overloaded. </li><li>14. The inhaler according to claim 1, wherein the rotary part has a rotor which is associated with a stator when the rotary part is rotated into the metering chamber (26).</li><li>15. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized by rotor-bearing rotor blades (47) extending from a ring disk (49) of the bottom of the rotating part (22).</li><li>16. Inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that the rotor blades (47) have a crescent-shaped outline.</li><li>17. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized by two mutually opposing rotor blades (47).</li><li>18. Inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that the rotor blades (47) extend essentially on a quarter sector with a flank (50) directed radially towards the center of the mandrel (25) and one approximately at right angles (51) in a tangentially aligned relationship with the mandrel (25).</li><li>19. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized in that the flanks (50) lie in a common diametral (yy). </li><li>20. The inhaler as claimed in claim 1, wherein the rotor (R) engages underneath the stator (St) such that the stator (St) is designed as a radially inward projecting from the inner wall of the supply chamber (11) Which extends freely into an orbital path (54) of the rotor (R).</li><li>21. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized in that the stator (St) has a trapezoidal contour with a base in the inner wall of the supply chamber (11).</li><li>22. Inhaler according to one or more of the preceding examples or in particular according thereto, characterized in that the orbit (54) is axially bounded by the underside of the annular disc (49 of the rotating part (22) and the inside of the rotor blades (47) facing it.</li><li>23. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized in that the stator (St) is arranged under the quarter sector leaving an interspace (55) between two rotor blades (47).</li><li>24. Inhaler according to one or more of the preceding examples, or in particular according thereto, characterized in that the guide opening (24) is lined in the rotating part (22) by a sealing bush (56) comprising the cylindrical section of the mandrel (25). </li><li>25. Inhaler according to one or more of the preceding examples or in particular according thereto, characterized by a sealing ring (58) inserted between the inner wall of the supply chamber (11) and the rotating part (22) with pretension.</li><li>26. An inhaler according to one or more of the preceding examples, or in particular according thereto, characterized in that the sealing ring (58) is nibbled into annular grooves (59, 60) of both parts, the annular groove (59) Shaped notch groove, and the ring groove (60) of the supply chamber (11), which is located parallel thereto, is half-round.</li><li>27. The inhaler as claimed in claim 1, wherein the closure cap is configured as a screw cap and interacts with the mouthpiece via rotation-receiving means (45/46).</li></ol>