EP1514934A3

Biosynthetic binding protein for cancer marker

Abstract

Disclosed is a single-chain Fv (sFv) polypeptide defining a binding site which exhibits the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen, the sFv includes at least two polypeptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N-terminus of the other, the amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), the CDRs conferring immunological binding to the c-erbB-2 or c-erbB-2-related tumor antigen.

EP1514934A3, drawing sheet 1 — Sheet 1 of 1

Term

Term ended

Projected expiry passed 5 February 2013, 13.6 years ago.

1 sheet

Sheet 1

Every citation, both waysCites: the store holds 3 of 4

Citations
Document	Relation	Office	Category	Cited during	Relevant claims
EP0502812A1	Cites	European Patent Office (EPO)	PA	Search report	1-21
WO8503523A1	Cites	World Intellectual Property Organization (WIPO)	A	Search report	1-21
WO9321319A1	Cites	World Intellectual Property Organization (WIPO)	E	Search report	1-21
RING D B ET AL: "IDENTITY OF BCA200 AND C-ERB-2 INDICATED BY REACTIVITY OF MONOCIONAL ANTIBODIES WITH RECOMBINANT C-ERBB-2", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 28, no. 8, August 1991 (1991-08-01), pages 915 - 917, XP000672774, ISSN: 0161-5890	Non-patent	–	–	Search report	–
SEFTON B M: "Neus about c-erb-B-3 and HER2", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 4, no. 9, September 1988 (1988-09-01), pages 247 - 248, XP002988523, ISSN: 0168-9525	Non-patent	–	–	Search report	–
SHEALY D ET AL: "CHARACTERIZATION AND BIODISTRIBUTION OF TC-99M LABELED SINGLE CHAIN ANTIBODY FV FRAGMENT (SFV)", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, RESTON, VA, US, vol. 31, no. 5, SUPPL, 1990, pages 776,ABSTRNO290, XP008042104, ISSN: 0161-5505	Non-patent	–	–	Search report	–

72 members in 8 offices

This recordMember, by publication datePriority claim

Priority claims9

Priority claims
Document	Office	Kind	Date
831967	United States of America	–	1992-02-06
83196792	United States of America	A	1992-02-06
83196792	United States of America	A	1992-02-06
93904938	European Patent Office (EPO)	A	1993-02-05
93904938	European Patent Office (EPO)	A	1993-02-05
831967	–	–	–
93904938	–	–	–
EP19930904938	–	–	–
US19920831967	–	–	–

Members72

Family members, oldest first
Document	Office	Kind
WO8809344A1	World Intellectual Property Organization (WIPO)	A1	1988-12-01
AU1804988A	Australia	A	1988-12-21
EP0318554A1	European Patent Office (EPO)	A1	1989-06-07
EP0318554A4	European Patent Office (EPO)	A4	1990-01-24
JPH02500329A	Japan	A	1990-02-08
AU612370B2	Australia	B2	1991-07-11
AU8579991A	Australia	A	1992-02-13
US5091513A	United States of America	A	1992-02-25
US5132405A	United States of America	A	1992-07-21
CA2129663A1	Canada	A1	1993-08-19
CA2372813A1	Canada	A1	1993-08-19
WO9316185A2	World Intellectual Property Organization (WIPO)	A2	1993-08-19
AU3612293A	Australia	A	1993-09-03
WO9316185A3	World Intellectual Property Organization (WIPO)	A3	1993-09-30
US5258498A	United States of America	A	1993-11-02
AU648591B2	Australia	B2	1994-04-28
EP0623679A1	European Patent Office (EPO)	A1	1994-11-09
EP0625200A1	European Patent Office (EPO)	A1	1994-11-23
EP0318554B1	European Patent Office (EPO)	B1	1995-04-05
AT120761T	Austria	T	1995-04-15
ATE120761T1	Austria	T1	1995-04-15
DE3853515D1	Germany	D1	1995-05-11
DE3853515T2	Germany	T2	1995-08-17
US5476786A	United States of America	A	1995-12-19
US5482858A	United States of America	A	1996-01-09
JPH08500962A	Japan	A	1996-02-06
US5534254A	United States of America	A	1996-07-09
AU675929B2	Australia	B2	1997-02-27
US5753204A	United States of America	A	1998-05-19
US5837846A	United States of America	A	1998-11-17
US5877305A	United States of America	A	1999-03-02
US6207804B1	United States of America	B1	2001-03-27
US2002168375A1	United States of America	A1	2002-11-14
CA1341415C	Canada	C	2003-01-07
EP0623679B1	European Patent Office (EPO)	B1	2003-06-25
AT243754T	Austria	T	2003-07-15
ATE243754T1	Austria	T1	2003-07-15
DE3856559D1	Germany	D1	2003-07-31
JP2003284577A	Japan	A	2003-10-07
DE3856559T2	Germany	T2	2004-04-29
EP0318554B2	European Patent Office (EPO)	B2	2005-01-12
EP1514934A2	European Patent Office (EPO)	A2	2005-03-16
US2005058638A1	United States of America	A1	2005-03-17
JP2005104965A	Japan	A	2005-04-21
EP0625200B1	European Patent Office (EPO)	B1	2005-05-11
AT295420T	Austria	T	2005-05-15
ATE295420T1	Austria	T1	2005-05-15
DE69333807D1	Germany	D1	2005-06-16
JP2005168489A	Japan	A	2005-06-30
CA2129663C	Canada	C	2005-07-05
DE3853515T3	Germany	T3	2005-08-25
DE69333807T2	Germany	T2	2006-02-02
EP1514934A3This record	European Patent Office (EPO)	A3	2006-04-19
US2006147444A1	United States of America	A1	2006-07-06
US7138497B2	United States of America	B2	2006-11-21
US2007031931A1	United States of America	A1	2007-02-08
JP2007228979A	Japan	A	2007-09-13
JP2007231027A	Japan	A	2007-09-13
EP1997894A2	European Patent Office (EPO)	A2	2008-12-03
JP2008289500A	Japan	A	2008-12-04
EP1514934B1	European Patent Office (EPO)	B1	2008-12-31
AT419355T	Austria	T	2009-01-15
ATE419355T1	Austria	T1	2009-01-15
DE69334255D1	Germany	D1	2009-02-12
JP2009035558A	Japan	A	2009-02-19
JP4236493B2	Japan	B2	2009-03-11
EP1997894A3	European Patent Office (EPO)	A3	2009-11-04
EP1997894B1	European Patent Office (EPO)	B1	2011-03-30
AT503496T	Austria	T	2011-04-15
ATE503496T1	Austria	T1	2011-04-15
DE69334351D1	Germany	D1	2011-05-12
CA1341614C	Canada	C	2011-05-24

45 legal events, as 6 offices reported them to INPADOC

Over the term

Point at a mark for the event

Events

Legal events, newest first
	Event	Code	Office
2013-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-02-27	Patent expired after termination of 20 yearsExpiredPE20	PE20	GB
2013-02-13	Discontinued because of reaching the maximum lifetime of a patentV4	V4	NL
2013-02-06	Expiry of rightR071	R071	DE
2013-02-05	Expiry of rightR071	R071	DE
2012-07-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2012-06-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2012-06-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2012-05-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2012-04-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2012-04-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2011-04-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-10-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2010-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-12-09	No opposition filedOpposition26N	26N	EP
2009-11-25	Patent lapsedLapsedMM4A	MM4A	IE
2009-11-06	No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE	PLBE	EP
2009-11-06	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA	STAA	EP
2009-10-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-09-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-02-18	European patents granted designating irelandGrantedFG4D	FG4D	IE
2009-02-12	Corresponds to:REF	REF	EP
2009-01-15	New agentNV	NV	CH
2008-12-31	Divisional application: reference to earlier applicationAC	AC	EP
2008-12-31	Designated contracting statesAK	AK	EP
2008-12-31	European patent takes effect as a national patent in ch/liEP	EP	CH
2008-12-31	European patent grantedGrantedFG4D	FG4D	GB
2008-11-28	(expected) grantORIGINAL CODE: 0009210GRAA	GRAA	EP
2008-08-20	Grant fee paidORIGINAL CODE: EPIDOSNIGR3GRAS	GRAS	EP
2008-03-12	Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOSNIGR1GRAP	GRAP	EP
2007-07-18	First examination report despatched17Q	17Q	EP
2007-01-24	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1	EP
2006-12-27	Designation fees paidAKX	AKX	EP
2006-10-04	Request for examination filed17P	17P	EP
2006-04-19	Designated contracting statesAK	AK	EP
2006-03-03	Search report despatchedORIGINAL CODE: 0009013PUAL	PUAL	EP
2005-03-16	Divisional application: reference to earlier applicationAC	AC	EP
2005-03-16	Designated contracting statesAK	AK	EP
2005-01-28	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI	EP

Biosynthetic binding protein for cancer marker

Abstract

Term

Priority claims9

Members72

Over the term

Events

Numbers

Titles3

Classification

Designated states17