Nova Patents
EP1514933A1

Secretory protein or membrane protein

Abstract

Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides of the present invention are used to produce these proteins.

EP1514933A1, drawing sheet 1
Sheet 1 of 225

Term

Term ended

Projected expiry passed 7 July 2020, 6.2 years ago.

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23 claims: 6 independent, 17 dependent

  1. 1
    An isolated polynucleotide selected from the group consisting of:(a) a polynucleotide comprising a coding region of the nucleotide sequence SEQ ID NO: 221;(b) a polynucleotide comprising a nucleotide sequence encoding a protein comprising the amino acid sequence SEQ ID NO: 222;(c) a polynucleotide comprising a nucleotide sequence encoding a protein comprising an amino acid sequence of (b) in which one or more amino acids are substituted, deleted, inserted, and/or added, wherein said protein is functionally equivalent to the protein comprising said amino acid sequence of (b);(d) a polynucleotide that hybridizes with a polynucleotide comprising a nucleotide sequence of (a), and that comprises a nucleotide sequence encoding a protein functionally equivalent to the protein encoded by the nucleotide sequence of (a);(e) a polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a protein encoded by the polynucleotide of (a) to (d);(f) a polynucleotide comprising a nucleotide sequence with at least 70% identity to the nucleotide sequence of (a).
  2. 3
    Use of an oligonucleotide as a primer for synthesizing the polynucleotide comprising the nucleotide sequence of SEQ ID NO:488 or the complementary strand thereof, wherein said oligonucleotide is complementary to said polynucleotide or the complementary strand thereof and comprises at least 15 nucleotides.
  3. 4
    A primer set for synthesizing polynucleotides, the primer set comprising an oligo-dT primer and an oligonucleotide complementary to the complementary strand of the polynucleotide comprising the nucleotide sequence of SEQ ID NO:488, wherein said oligonucleotide comprises at least 15 nucleotides.
  4. 5
    A primer set for synthesizing polynucleotides, the primer set comprising a combination of an oligonucleotide comprising a nucleotide sequence complementary to the complementary strand of the polynucleotide comprising a 5'-end nucleotide sequence and an oligonucleotide comprising a nucleotide sequence complementary to the polynucleotide comprising a 3'-end nucleotide sequence, wherein said oligonucleotides comprise at least 15 nucleotides and wherein said combination of 5'-end nucleotide sequence and 3'-end nucleotide sequence is SEQ ID NO:488 and SEQ ID NO: 630.
  5. 10
    An antibody against the protein or peptide of any one of claims 2, 8, and 9.
  6. 23
    A database of polynucleotides and/or proteins, the database comprising information on at least one sequence of SEQ ID NO:221 or SEQ ID NO: 222, or a medium on which the database is stored.
Independent claims6