Nova Patents
EP1513397A4

Transgenic ungulates capable of human antibody production

Abstract

The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.

Term

Term ended

Projected expiry passed 19 May 2023, 3.4 years ago.

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Every citation, both waysCites: the store holds 6 of 7

Citations
DocumentRelationOfficeCategoryCited duringRelevant claims
WO0135735A1CitesWorld Intellectual Property Organization (WIPO)XSearch report3-7,11
WO02070648A2CitesWorld Intellectual Property Organization (WIPO)PXSearch report1-19,45
EP0773288A2CitesEuropean Patent Office (EPO)YSearch report1-45
WO0135735ACitesWorld Intellectual Property Organization (WIPO)–––
WO02070648ACitesWorld Intellectual Property Organization (WIPO)–––
EP0773288ACitesEuropean Patent Office (EPO)–––
KUROIWA Y ET AL: "Cloned transchromosomic calves producing human immunoglobulin", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 20, no. 9, September 2002 (2002-09-01), pages 889 - 894, XP002976595, ISSN: 1087-0156Non-patent––Search report–
ROBL JAMES M: "Application of cloning technology for production of human polyclonal antibodies in cattle", CLONING AND STEM CELLS, vol. 9, no. 1, April 2007 (2007-04-01), pages 12 - 16, XP002449218, ISSN: 1536-2302Non-patent––Search report–
TOMIZUKA K ET AL: "FUNCTIONAL EXPRESSION AND GERMLINE TRANSMISSION OF A HUMAN CHROMOSOME FRAGMENT IN CHIMAERIC MICE", NATURE GENETICS, NEW YORK, NY, US, vol. 16, no. 2, 16 June 1997 (1997-06-16), pages 133 - 143, XP000770172, ISSN: 1061-4036Non-patent––Search report–
CIBELLI J B ET AL: "CLONED TRANSGENIC CALVES PRODUCED FROM NONQUIESCENT FETAL FIBROBLASTS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 280, 22 May 1998 (1998-05-22), pages 1256 - 1258, XP000786003, ISSN: 0036-8075Non-patent––Search report–
KIKYO NOBUAKI ET AL: "Reprogramming nuclei: Insights from cloning, nuclear transfer and heterokaryons", JOURNAL OF CELL SCIENCE, CAMBRIDGE UNIVERSITY PRESS, LONDON, GB, vol. 113, no. 1, January 2000 (2000-01-01), pages 11 - 20, XP002176693, ISSN: 0021-9533Non-patent––Search report–