EP1511845A2

Immunostimulatory oligonucleotides and uses thereof

Abstract

Oligonucleotides containing the non-palindromic sequence motif: X1X2X3X4X5X6X7X8, wherein X1 is C, T, G or A (preferably T or C); X2 is C, T, G or A; X7 is C, T, G or A (preferably G); at least three, and preferably all, of X3, X4, X5, X6 and X8 are T; with the proviso that, in the motif, a C does not precede a G (in other terms, the nucleic acid motif does not consist of a CpG oligonucleotide), that modulate the immune response of animals of the order Primate, including humans are disclosed. This immune modulation is characterized by stimulation of proliferation, differentiation, cytokine production and antibody production on B-cells and cell differentiation, cytokine production and antibody production on B-cells and cell differentiation on plasmacytoid dendritic cells.

Term

Term ended

Projected expiry passed 30 May 2023, 3.3 years ago.

Every citation, both ways

Citations
Document	Relation	Office	Cited during
WO2007089051A1	Cited by	World Intellectual Property Organization (WIPO)	Search report
WO2007089051A1	Cited by	World Intellectual Property Organization (WIPO)	International search

28 members in 14 offices

This recordMember, by publication datePriority claim4 more offices are in the list below

Priority claims3

Priority claims
Document	Office	Kind	Date
2388049	Canada	–	2002-05-30
2388049	Canada	A	2002-05-30
0305691	European Patent Office (EPO)	W	2003-05-30

Members28

Family members, oldest first
Document	Office	Kind
CA2388049A1	Canada	A1	2003-11-30
CA2487904A1	Canada	A1	2003-12-11
WO03101375A2	World Intellectual Property Organization (WIPO)	A2	2003-12-11
AU2003250334A1	Australia	A1	2003-12-19
US2004006032A1	United States of America	A1	2004-01-08
WO03101375A3	World Intellectual Property Organization (WIPO)	A3	2004-09-02
KR20050005521A	Republic of Korea	A	2005-01-13
EP1511845A2This record	European Patent Office (EPO)	A2	2005-03-09
JP2005533491A	Japan	A	2005-11-10
US2005276789A1	United States of America	A1	2005-12-15
US7038029B2	United States of America	B2	2006-05-02
MXPA04011937A	Mexico	A	2006-06-27
MXPA04011937A	Mexico	A	2006-06-27
NZ536962A	New Zealand	A	2006-09-29
US7381807B2	United States of America	B2	2008-06-03
AU2003250334B2	Australia	B2	2008-06-05
US2009060937A1	United States of America	A1	2009-03-05
JP4568907B2	Japan	B2	2010-10-27
US7943316B2	United States of America	B2	2011-05-17
EP1511845B1	European Patent Office (EPO)	B1	2012-01-11
AT541039T	Austria	T	2012-01-15
ATE541039T1	Austria	T1	2012-01-15
PT1511845E	Portugal	E	2012-04-13
DK1511845T3	Denmark	T3	2012-05-07
ES2380796T3	Spain	T3	2012-05-18
US2013243811A1	United States of America	A1	2013-09-19
US8871436B2	United States of America	B2	2014-10-28
CY1112588T1	Cyprus	T1	2016-02-10

81 legal events, as 16 offices reported them to INPADOC

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	Event	Code	Office
2023-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2023-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2023-06-21	Patent expired after termination of 20 yearsExpiredPE20	PE20	GB
2023-06-06	Announcement of lapse in spainLapsedFD2A	FD2A	ES
2023-05-30	Expiry of rightR071	R071	DE
2022-07-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2022-07-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2022-07-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2022-07-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2022-07-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2022-06-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-05-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-03-19	Lapsed because of non-payment of the annual feeLapsedMM	MM	BE
2021-02-26	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-29	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-01-06	Lapsed because of non-payment of the annual feeLapsedMM	MM	NL
2020-12-21	Ep patent lapsedLapsedEBP	EBP	DK
2020-12-17	Ep patent expiredExpiredMAE	MAE	FI
2019-09-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-08-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-08-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-08-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-08-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-08-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-07-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-07-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-07-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2019-06-28	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2018-05-25	Fee paymentPLFP	PLFP	FR
2017-05-25	Fee paymentPLFP	PLFP	FR
2016-05-30	Fee paymentPLFP	PLFP	FR
2014-05-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-02-28	Filing of the translation of the text of european patentsAG4A	AG4A	HU
2013-02-07	No opposition filed against granted patent, or epo opposition proceedings concluded without decisionGrantedR097	R097	DE
2013-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-12-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-12-19	No opposition filedOpposition26N	26N	EP
2012-11-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-11-16	No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE	PLBE	EP
2012-11-16	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA	STAA	EP
2012-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-09-15	Deletion acc. to par. 5 (withdrawal of the translation of the ep patent)MK05	MK05	AT
2012-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-06-18	Ep patent validated in greeceEP	EP	GR
2012-05-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-05-18	Definitive protectionFG2A	FG2A	ES
2012-05-07	Ep patent with danish claimsT3	T3	DK
2012-04-24	Translation of granted ep patentGrantedTRGR	TRGR	SE
2012-04-18	Translation filed for an european patent granted for nl, confirming art. 52 par. 1 or 6 of the patents act 1995GrantedT3	T3	NL
2012-04-13	Translation is availableAVAILABILITY OF NATIONAL TRANSLATIONSC4A	SC4A	PT
2012-03-08	Dpma publication of mentioned ep patent grantGrantedR096	R096	DE
2012-02-01	European patents granted designating irelandGrantedFG4D	FG4D	IE
2012-01-15	Reference to at number (ep patent validated in austria)REF	REF	AT
2012-01-13	European patent takes effect as a national patent in ch/liEP	EP	CH
2012-01-11	Designated contracting statesAK	AK	EP
2012-01-11	European patent grantedGrantedFG4D	FG4D	GB
2011-12-09	(expected) grantORIGINAL CODE: 0009210GRAA	GRAA	EP
2011-05-19	Grant fee paidORIGINAL CODE: EPIDOSNIGR3GRAS	GRAS	EP
2011-03-23	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1	EP
2010-08-20	Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOSNIGR1GRAP	GRAP	EP
2010-07-28	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2010-07-28	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2010-07-28	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2010-07-28	Information provided on ipc code assigned before grantRIC1	RIC1	EP
2007-11-28	First examination report despatched17Q	17Q	EP
2005-09-21	Request for extension of the european patent (deleted)DAX	DAX	EP
2005-03-09	Request for examination filed17P	17P	EP
2005-03-09	Designated contracting statesAK	AK	EP
2005-03-09	Request for extension of the european patentAX	AX	EP
2005-01-21	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI	EP

Immunostimulatory oligonucleotides and uses thereof

Abstract

Term

Priority claims3

Members28

Over the term

Events

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Titles3

Classification

Designated states31