EP1483384A4

Method for overexpression of zwitterionic polysaccharides

Abstract

The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.

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Projected expiry passed 13 March 2023, 3.5 years ago.

Every citation, both ways

Citations
Document	Relation	Office	Category	Cited during	Relevant claims
WO9607427A1	Cites	World Intellectual Property Organization (WIPO)	X	Search report	29-32,35-39,41,42,52-57,60-63
WO9607427A	Cites	World Intellectual Property Organization (WIPO)	–	–	–
KRINOS C M ET AL: "Extensive surface diversity of a commensal microorganism by multiple DNA inversions.", NATURE. 29 NOV 2001, vol. 414, no. 6863, 29 November 2001 (2001-11-29), pages 555 - 558, XP002367141, ISSN: 0028-0836	Non-patent	–	–	Search report	–
TZIANABOS A O: "Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function.", CLINICAL MICROBIOLOGY REVIEWS. OCT 2000, vol. 13, no. 4, October 2000 (2000-10-01), pages 523 - 533, XP002398507, ISSN: 0893-8512	Non-patent	–	–	Search report	–
BRUBAKER J O ET AL: "Mitogenic activity of purified capsular polysaccharide A from Bacteroides fragilis: differential stimulatory effect on mouse and rat lymphocytes in vitro", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 162, no. 4, 15 February 1999 (1999-02-15), pages 2235 - 2242, XP002206687, ISSN: 0022-1767	Non-patent	–	–	Search report	–
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, WEINACHT K G ET AL: "Phase variation of the capsular polysaccharides of Bacteroides fragilis is dictated by site-specific recombinases", XP002371648, Database accession no. PREV200200585500	Non-patent	–	–	Search report	–

22 members in 7 offices

This recordMember, by publication datePriority claim

Priority claims3

Priority claims
Document	Office	Kind	Date
364168P	United States of America	–	2002-03-13
36416802	United States of America	P	2002-03-13
0307775	United States of America	W	2003-03-13

Members22

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Document	Office	Kind
CA2479246A1	Canada	A1	2003-09-25
WO03077863A2	World Intellectual Property Organization (WIPO)	A2	2003-09-25
AU2003218144A1	Australia	A1	2003-09-29
US2003219413A1	United States of America	A1	2003-11-27
WO03077863A3	World Intellectual Property Organization (WIPO)	A3	2004-07-22
EP1483384A2	European Patent Office (EPO)	A2	2004-12-08
JP2005519617A	Japan	A	2005-07-07
EP1483384A4This record	European Patent Office (EPO)	A4	2006-11-02
US7166455B2	United States of America	B2	2007-01-23
US2007020730A1	United States of America	A1	2007-01-25
US2007154991A1	United States of America	A1	2007-07-05
US2008057565A1	United States of America	A1	2008-03-06
AU2003218144B2	Australia	B2	2008-08-14
AU2008243143A1	Australia	A1	2008-11-27
US7678558B2	United States of America	B2	2010-03-16
US7803602B2	United States of America	B2	2010-09-28
JP4733349B2	Japan	B2	2011-07-27
EP1483384B1	European Patent Office (EPO)	B1	2012-01-11
AT541036T	Austria	T	2012-01-15
ATE541036T1	Austria	T1	2012-01-15
AU2008243143B2	Australia	B2	2012-10-04
CA2479246C	Canada	C	2017-05-09

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2022-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2022-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2022-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2022-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2022-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2021-11-24	Gb: european patent ceased through non-payment of renewal feeCeasedGBPC	GBPC	EP
2021-10-29	Patent ceasedCeasedPL	PL	CH
2021-10-01	Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal feeWithdrawnR119	R119	DE
2020-07-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2020-06-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2020-05-01	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2020-05-01	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2018-03-26	Fee paymentPLFP	PLFP	FR
2017-03-27	Fee paymentPLFP	PLFP	FR
2016-03-28	Fee paymentPLFP	PLFP	FR
2014-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-05-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2014-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-02-07	No opposition filed against granted patent, or epo opposition proceedings concluded without decisionGrantedR097	R097	DE
2013-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-01-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2013-01-02	Patent lapsedLapsedMM4A	MM4A	IE
2012-12-19	No opposition filedOpposition26N	26N	EP
2012-11-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
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2012-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-10-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-09-28	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-09-15	Deletion acc. to par. 5 (withdrawal of the translation of the ep patent)MK05	MK05	AT
2012-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-07-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
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2012-05-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2012-05-02	Discontinued in the netherlands as no translation has been filedVDEP	VDEP	NL
2012-03-08	Dpma publication of mentioned ep patent grantGrantedR096	R096	DE
2012-02-01	European patents granted designating irelandGrantedFG4D	FG4D	IE
2012-01-15	Reference to at number (ep patent enters austrian national phase)REF	REF	AT
2012-01-13	European patent takes effect as a national patent in ch/liEP	EP	CH
2012-01-11	Designated contracting statesAK	AK	EP
2012-01-11	European patent grantedGrantedFG4D	FG4D	GB
2011-12-09	(expected) grantORIGINAL CODE: 0009210GRAA	GRAA	EP
2011-12-07	Grant fee paidORIGINAL CODE: EPIDOSNIGR3GRAS	GRAS	EP
2011-07-22	Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOSNIGR1GRAP	GRAP	EP
2007-01-24	First examination report despatched17Q	17Q	EP
2006-11-02	Supplementary search report drawn up and despatchedA4	A4	EP
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2004-10-22	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI	EP

Method for overexpression of zwitterionic polysaccharides

Abstract

Term

Priority claims3

Members22

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